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Here we compare today’s top trending exotic cannabinoids so consumers can make the most informed decisions. However, most exotic cannabinoids are semi-synthetically made and have unique qualities that consumers need to understand. Quantifying essential alkaloids across hemp, cannabis, kratom, and mushrooms. Both hemp-derived Delta-8 and Delta-9 THC fall through a sort of legal loophole. They’re federally legal, despite their marijuana-derived twins being federally illegal. The Delta-9 extracted from marijuana is only legal in states where marijuana is legal, whether for medicinal or recreational purposes. Then, your fun friend pours you a mimosa, and it’s half Champagne and half OJ. Yet, Delta-8 binds as strongly to CB2 receptors as Delta-9, and CB2 receptors play a role in suppressing inflammation. In a short-term study, dose-dependent effects on the reduction of heart rate were observed in rats while complete tolerance to the decrease in heart rate was established within only 13 days . Doses ranging from 1 to 6 mg of Δ8-THC intravenously induce a broad spectrum of effects reminiscent of cannabis . Evaluating the effects of Δ8-THC on pigeons suggested a dose-dependent effect of Δ8-THC on pigeons trained with Δ9-THC, thus mirroring similar findings reported in rats . This result was in agreement with another study that identified the discriminative stimulation effects of Δ8-THC . THC-O acetate does not naturally occur in hemp or cannabis plants. However, as state and federal agencies continue to ban Delta-8 THC and other synthetic cannabinoids, some have also banned analogs like HHC. HHC is federally legal because it is a hemp derivative covered under the 2018 Farm Bill. HHC products are semi-synthetically produced from cannabis extracts via a “hydrogenation” process. It does not occur naturally in hemp and cannabis plants. Do Delta 8 Edibles Get You High?

Delta-8 THC offers a legal high, but here's why the booming business may soon go up in smoke. 5 things to know about delta-8 tetrahydrocannabinol – delta-8 THC. Analysis of cannabis seizures by non-targeted liquid chromatography-tandem mass spectrometry.

However, Delta-8 products are not natural extracts.
But Delta-9 extracted from hemp — it’s the exact same compound, it just came from a different kind of cannabis plant — is federally legal under the 2018 Farm Bill.
These cumulative results support the potential therapeutic relevance of Δ8-THC in combating cancer through diverse mechanisms, warranting further exploration and clinical investigation.
Very little human research has been done on delta-8 THC.
It’s still a psychoactive cannabinoid that will have you feeling high, just not sky-high.
Chemical structures of Δ8-THC and its related impurities found in Δ8-THC commercial products.
Delta-10 products are increasingly popular, and many product types are on the market for users to vape and ingest.

It needs to stay accessible and affordable for the people that can really benefit.” The sixth most common theme was substitution of delta-8-THC for other substances. Many participants had similar statements such as “Delta 8 is a great thing. The fifth most common theme was general expressions of praise for delta-8-THC. I do wish there was regulation purely for safety concerns; more reliable lab testing, testing specifically for solvents and reagents used in delta-8-THC production, etc. Delta-8 I do not and it relieves symptoms of PTSD and anxiety pretty quickly.” The third most common theme was comments on the study or researchers. A subsequent in vitro study in rats investigated changes in contractility by measuring nitric oxide production recording a significant reduction . In a conflicting study, Gong and colleagues conducted a three-part experiment examining bronchodilation and tolerance to Δ8-THC. Additionally, the same study showed that Δ8-THC exhibited an additional protective effect against seizures when combined with phenobarbital, but not with diphenylhydantoin . These effects are facilitated through the involvement of both ATP- and apamin-sensitive potassium channels . These receptors lead to a decrease in both calcium entry into neurons and the calcium content. For brands selling end-products online and across multiple states. Ensuring products are safe & free from common adulterants. For hemp growers, producers, and brands nationally and in 16+ countries Summit THC also sells (legally!) these Delta-9 THC Gummies, which are more potent, delivering a fun and hazy high. I know all this can be dizzying, and I hope one day we don’t have to navigate so many complex laws concerning cannabis. Manufacturers synthesize THC-O through a chemical process. Commercial THCO products typically share the same base structure as Delta-8 THC. THCO is a more potent analog of Delta-9 THC, meaning its psychedelic effects can be more intense. In larger doses, some say THC-O can be borderline psychedelic with potent couch-lock effects. As a result, the DEA recently issued an opinion that it does not fall under the Farm Bill's hemp definition. We developed an anonymous Qualtrics online survey to assess experiences with delta-8-THC. We combine quantitative rating items with open-ended qualitative items enabling participants to provide feedback which is rich in content. Because this is the first large survey of delta-8-THC consumers, we take an exploratory approach to describe experiences with delta-8-THC. The researchers concluded that delta-8-THC was a more stable compound than the more well-studied delta-9-THC (Abrahamov et al. 1995, consistent with other findings (Zias et al. 1993), and suggested that delta-8-THC could be a better candidate than delta-9-THC for new therapeutics. 2. Analysis of Δ8-THC, Impurities, and Possible Contaminants in Commercial Consumer Products

2. Analysis of Δ8-THC, Impurities, and Possible Contaminants in Commercial Consumer Products

In summary, the diverse array of studies examining the effects of Δ8-THC across different cells, organs, and systems underscores its multifaceted immunomodulatory impact. To facilitate a comprehensive grasp of these findings, a subset of these studies has been thoughtfully consolidated and presented in Table 3 for easy reference and analysis. These cumulative results support the potential therapeutic relevance of Δ8-THC in combating cancer through diverse mechanisms, warranting further exploration and clinical investigation.

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Embarking on this tranquil journey with Just Delta might require patience, as the effects take time to work but remain for an extended duration. Moreover, as gummies are edibles, the onset of Delta 8’s effects might be gradual but tend to be more intense and long-lasting. It’s important to acknowledge that Delta 8’s effects can be as different as individuals themselves. Immerse yourself in the effects of Delta 8 gummies. Depending on the strain it has taken the place of melatonin for sleep.”; “As with any newer drug with limited study, care should be taken with its use. It has much milder to nonexistent aftereffects”; “Delta 8 is not as heavy as Delta 9. The most common theme was comparisons between delta-8-THC and delta-9-THC. Participants reported low levels of distressing mental states (anxiety and paranoia). In 2018, Congress passed the farm bill, which legalized chemicals derived from hemp. So delta-8 products made from hemp CBD could be contaminated with heavy metals, pesticides, and mold — all of which could make it into your body if you consume them. This means it’s likely to have psychoactive effects and show up on a drug test. The precise clinical implications of these effects on fertility remain uncertain and warrant further investigation . In another study, rats that were exposed chronically to Δ8-THC displayed significantly reduced body weight and lower levels of follicle-stimulating hormone and luteinizing hormone in comparison to the control group. They also caused a loss of muscle coordination, diminished sensorimotor responses, and elicited a hunched posture and gait reminiscent of the effects induced by narcotic analgesics. In another study, topical Δ8-THC did eventually lead to a reduction in intraocular pressure in rabbits . An early study involving eight rabbits observed a decrease in the intraocular pressure following intravenous administration of Δ8-THC, but this effect was not dose-dependent . In other words, the manufacturing of delta-8 products leaves a lot of room for error and accidental poisoning. But harmful toxins can get left behind in the product as a result of the chemical processes that make delta-8. The packaging and labeling of delta-8 products can be very confusing and misleading. In response, several states have banned the sale of delta-8 THC products, citing concerns over public health and safety. The analysis was performed using a fused silica capillary column and a temperature program from 150 °C to 280 °C . The identified Δ8-THC amount was below the limit of quantification of the reported method (1.25 ng/mL) . As a result, for accurate analysis of Δ8-THC, a full chromatographic separation has to be achieved. You can even cut a piece in half, as you don’t need much delta eight. What may help your body completely relax before bedtime may have minimal effects, if any, on another user. There is not one perfect dose for enjoying the benefits of edible delta 8.

How Many THC Gummies Should You Eat?

The endocannabinoid system comprises the endocannabinoids, cannabinoid receptors, and enzymes responsible for the synthesis and degradation of endocannabinoids . An HPLC-MS/MS method was developed for the analysis of Δ8-THC, Δ9-THC, CBD, and 10 additional cannabinoids and their metabolites in oral fluid (including 11-OH-Δ9-THC, Δ9-THC-COOH, THCV, CBDV, cannabidiorcol (CBD-C1), CBC, CBN, and CBG . The main cause of the presence of THC isomers is probably due to exposure of cannabis source materials, such as cannabis concentrates or converted hemp materials, to chemical and thermal treatments during the manufacturing process. In one study, in addition to Δ8-THC, the cannabinoids Δ9-THC, CBD, 9(S/R)-Δ6a,10a-THC, and (6aR,9R)-Δ10-THC were identified in an e-cigarette cartridge. By the year 2020, the Interim Final Rule (2020 IFR) issued by the Drug Enforcement Administration (DEA) confirmed that hemp-derived THC products are not legalized by the 2018 Farm Bill . That’s why we made this guide, so you can get to know these cannabinoids the same way we do—and so you can shop accordingly. While perusing the modern selection of cannabis goods, you likely have noticed ‘Delta’ products…but many don’t know the difference between Delta-8 vs. Delta-9 before buying. It’s chemically similar to THC, but doesn’t have the same effects. The most commonly reported adverse events were related to psychiatric disorders, followed by respiratory, thoracic, and mediastinal issues, as well as nervous system problems. The CDC advises caution, noting that Δ8-THC products can be intoxicating, may have misleading labels, and should be kept away from children . It highlights that emergency room visits mentioning Δ8-THC as the primary complaint were mostly concentrated in southern states without legal adult-use marijuana access. On 14 September 2020, the Centers for Disease Control and Prevention (CDC) announced an alert, warning healthcare workers and the public about the recent rise in adverse health events related to Δ8-THC consumption. Finally, manufacturers’ packaging Δ8-THC products in ways appealing to children is a notable concern, as this could lead to unintentional exposure .

They are rather inexpensive too, considering all the physical and emotional benefits of delta-8 gummies that consumers get to enjoy.
Substitution of delta-8-THC for delta-9-THC may be consistent with harm reduction, one of the core principles of Public Health.
Most delta-8 THC products currently being sold are manufactured without following any safety regulations.
Here's where (and why) the hemp product skirts marijuana laws.
Manufacturing and sales of delta-8-THC products skyrocketed due to greater accessibility to fulfill market demand.
In contrast, when considering mouse CB1 and CB2 receptors, Δ8-THC exhibited binding affinities, as measured by Ki values, within a range of 39.3 nM to 179 nM 92,95,96,97,98,99,100.
Like THC, Delta 8 does show potential for aid in insomnia, anxiety, lack of appetite, and depression.

The bottom line: When choosing a cannabinoid, consider your goals as well as safety

The discussion on methods of analysis and detection of impurities in marketed products serves as a valuable guide for researchers, industry professionals, and regulatory bodies. The review shed light on its emergence as a psychoactive cannabinoid with increased popularity, driven by its superior stability and the easy synthetic procedure compared to the more well-known Δ9-THC. In conclusion, more clinical research is required to determine the potential benefits of Δ8-THC; however, legal concerns make these types of studies challenging. The study results showed that all three treatments produced similar somatic, psychic, and perceptual effects. The first clinical study was conducted in 1973 on six participants for the comparison between Δ8-THC and Δ9-THC following orally and intravenously administered doses . He and Radwan et al. independently reported affinity values of 78 nM and 12 nM against CB1 and CB2 receptors in human-transfected cells (HEK293), respectively. In detail, Govaerts and colleagues examined binding affinities of Δ8-THC in both murine tissues and cultured cells, that were genetically modified to express human cannabinoid receptors. Notably, the Δ8-THC intriguing effects are not restricted to a specific species, as evidenced by consistent impacts observed across human, rat, and mouse receptors. A recent study on the stability of Δ8-THC and its metabolites; 11-OH-Δ8-THC and Δ8-THC-COOH in drug-free urine was reported. More than 125 cannabinoids—oxygen-containing C21 aromatic hydrocarbons—were identified from C. Due to the variation in the concentration of Δ9-THC in the many cannabis plant varieties, three phenotypes were recognized, mainly for legal classification reasons. The various methods of analysis and detection of impurities present in the marketed products will be discussed. The researchers postulated that Δ8-THC is an artifact formed during the extraction procedure or GC analysis. In the same year, the same research group reported that chloroform is an efficient extraction solvent for C. At the end of the study, it was concluded that the concentration of Δ9-THC, and Δ9-THC acid A was decreased as the storage temperature increased, while the CBN content increased with increasing temperature, except that it decomposed at 80 °C after 50 weeks. In these cases, Δ8-THC products are often marketed as hemp products, potentially leading to accidental intoxication due to consumer confusion. The mechanism of Δ8-THC in corneal injury treatment was found to be mediated by cannabinoid receptors, as a study observed reduced pain and inflammation after corneal injury in mice with topical administration of Δ8-THC . This implies a potentially intricate role of cannabinoid receptors involving various subtypes and distinct localization throughout the central nervous system . In a more comprehensive investigation, Welch and his team administered CB1 and CB2 selective antagonist (SR141716A) alongside Δ8-THC using the tail-flick test to uncover any potential analgesic role through the cannabinoid receptors. These comprehensive findings depict Δ8-THC as a versatile modulator of cannabinoid receptors, exerting intricate effects at molecular and cellular levels across diverse biological systems. But it’s been suggested that delta-8 may have fewer side effects compared to stronger cannabinoids like delta-9 THC. Some products may be misleadingly labeled as “hemp products”, potentially leading consumers to underestimate their psychoactive effects. CB1 receptors are highly concentrated in specific brain regions and are less abundant in a more widespread manner, primarily influencing the psychoactive effects of cannabinoids. Turner et al. (1973) reported a 2-year stability study of the four cannabinoids, Δ9-THC, Δ9-THC acid A, CBD, and CBN in dried cannabis plant samples stored at five different temperatures (−18 °C, 4˚C, 22 °C, 37 °C, and 50 °C). It binds to CB1 receptors in your brain with the kind of intensity you’d expect from a compound that’s inspired some of the world’s objectively greatest music. Today, both Delta-8 and Delta-9 are found in everything from gummies to vape carts to tinctures—and each has carved out a unique niche in the ever-expanding cannabis marketplace. Consumers, in turn, enjoyed access to a gentle, legal high (more about that, later). Enter Delta-8 THC—a molecular sibling that occurs in trace amounts in the plant but can be synthesized from hemp-derived CBD in a lab. In a study exploring the reducing power of Δ8-THC against seizure manifestations, chronic administration of intraperitoneal 15 mg/kg Δ8-THC rapidly led to tolerance in preventing seizure activity. Furthermore, the development of cross-tolerance to the prolongation of pentobarbital-induced sleep by Δ8-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol was reported in mice . When considering morphine interactions, a study did find that morphine-tolerant mice treated with Δ8-THC induced heightened catalepsy rather than cross-tolerance . The authors claimed that “this is the first report of a method that successfully quantitates these primary cannabinoids in blood specimens where significant concentrations of both Δ8-THC and Δ9-THC isomers are present” . A liquid–liquid extraction protocol was used for extracting the target cannabinoids from whole blood. In order to avoid strong acidic conditions preventing CBD conversion to Δ8-THC, LC-MS/MS methods using solid phase extraction and solid phase microextraction methods were optimized for the measurement of cannabinoids including Δ8-THC in oral fluid (Table 1) 79,80,81. The best delta 8 edibles on the market are always laboratory tested at third party facilities to confirm a consumer’s safety. Then there are all the physical and emotional benefits that men and women get to enjoy from the delta 8 edibles.

Analysis

Delta-8 products made from hemp plants are popular because they’re federally legal. All three cannabinoids have health benefits and produce a ‘high.’ But their effects differ from one another. Delta-9 THC is the most well-known because it’s the dominant chemical compound in cannabis. Delta-8, delta-9, and delta-10 are all forms of tetrahydrocannabinol (THC), a type of cannabinoid in cannabis. These products are manufactured from CBD derived from CBD-rich hemp flowers, mainly based on the acid cyclization of cannabidiol (CBD) as the reactant (Figure 4). In the United States, commercial products containing Δ8-THC in high concentrations are gaining popularity, since the 2018 Farm Bill made tremendous changes to the regulation of hemp products . The technique cannot distinguish Δ8-THC from interfering cannabinoids such as Δ9-THC, CBD, CBC, and CBL, based on the analyte’s mass-to-charge ratio (m/z), as they exhibit nearly identical m/z values and share matching fragmentation spectra . Generally, LC-MS/MS techniques are used for analyzing Δ8-THC in complex cannabis matrices, such as blood samples or food products. Based on the author’s claim, the use of 275 nm detection wavelength gave a significantly better sensitivity (signal-to-noise ratio) than the conventional 228 nm wavelength commonly used for cannabinoid analysis. Δ8-THC marketed products were found to contain unnatural cannabinoids suggesting these were of synthetic origin . In 2012, Trofin et al. developed a GC-MS method for the determination of cannabinoids with baseline separation of Δ8-THC and Δ9-THC, in different types of herbal cannabis. Christinat et al. (2020) developed and validated an LC-MS/MS method for the quantification of 15 phytocannabinoids, including Δ8-THC in different food products. A UPLC-PDA method was developed and validated by Song et al. (2022) for the determination of 16 cannabinoids, including Δ8-THC in different hemp-derived concentrates. More research and tighter regulations are needed before considering OTC delta-8 products safe to consume. They are currently a safer choice than OTC delta-8 products. Delta-9 THC and delta-8 THC products sold at state-licensed dispensaries are regulated. While most people have heard about the main types of cannabinoids, such as THC and CBD, there is another upcoming compound in cannabis products, Delta 8 THC. The main difference between exotic cannabinoids and Delta-9 THC is how they occur, their molecular structures, psychoactive intensity, and legality. But Delta-9 extracted from hemp — it’s the exact same compound, it just came from a different kind of cannabis plant — is federally legal under the 2018 Farm Bill. Increases in availability of cannabis products containing delta-8 THC and reported cases of adverse events. And, because delta-8 THC currently exists in a legal gray area, you don’t get any of the benefits that you would with regulated cannabis products. Ten Δ8-THC products, including distillates and vaporizers, were analyzed during the study. Moreover, all the products contained reaction by-products in addition to olivetol, including Δ4,8-iso-THC, 9-ethoxyhexahydrocannabinol (9-EtO-HHC), Δ9-THC, and a previously unidentified cannabinoid (iso-THCBF, Figure 5) in addition to heavy metals . The study found that none of the analyzed products had accurate labeling of Δ8-THC content (within a range of ±20% of the concentration on the label). The presence of olivetol was also reported by Meehan-Atrash and Rahman (2021) as a contaminant in 27 Δ8-THC products . In order to address this emerging class of Δ8-THC containing consumer products, different analytical techniques have been reported in the literature. HHCP Legality

These effects were noticeable within the range of doses of Δ8-THC and accompanied by complete tolerance . In a short-term study, dose-dependent pain relief and body temperature decrease were observed in rats after Δ8-THC administration. Interestingly, this is one of the few effects where Δ8-THC did not exhibit a clear dose dependency . Although this did not directly assess the potential discriminative effect of Δ8-THC itself, these authors did find that Δ8-THC altered the dose–response curve of PCP’s discriminative stimulus. The study explored the induction and reversal of memory and learning impairment as a means to differentiate between substances, achieved by altering the ‘correct’ choice . Several scientific in vitro and in vivo studies have explored the potential anti-cancer effects of Δ8-THC. The factors that could be involved in such results include a potential biphasic or antagonist effect at higher doses, in addition to the receptor downregulation and subsequent alterations in the endocannabinoid system . Another study suggested alterations in the activity of monoamine oxidase enzymes in the hearts of live rats as a potential mechanism for bronchodilation and tachycardia. The efficacy of these products has not been confirmed by FDA-approved research. CBD and the more common Delta 9 THC has a respectable name in the cannabis industry. This does not occur in everyone, but this has deterred people from consuming Delta 9 THC products. But just like Delta 9 THC, it can also be combined with CBD for a further diminished psychoactive effect. Marijuana-derived Delta-9 THC and hemp-derived Delta-9 THC are one and the same, but only the latter is federally legal. The 2018 Farm Bill legalized hemp and removed it from categorization as a Class I drug (Hallelujah!). BOTH hemp and marijuana are types of cannabis. It’s still a psychoactive cannabinoid that will have you feeling high, just not sky-high. Pharmacological specificity of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rhesus monkeys. Speak with a Leafwell provider to decide which cannabinoid is right for you. Understanding their differences can help you choose the best one for your cannabis-related goals. MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Further research and ongoing scrutiny are warranted to better understand the compound’s properties, implications, and potential applications. This review presents all the currently available data regarding the isolation, synthesis, analysis, and biological profile and regulation of Δ8-THC and its products. Since these products are not approved nor evaluated for safety and/or analyzed for content, the cause of these adverse effects cannot be currently attributed to Δ8-THC alone. Among these reported adverse effects, 55% required intervention, such as evaluation by emergency medical services or hospitalization . Based on the fact that Δ8-THC in commercial products is chemically synthesized in an unregulated market, the presence of impurities and byproducts, as well as residual solvents, is often likely. The improved stability of Δ8-THC and its derivatives compared to Δ9-THC, coupled with the ease of its synthesis qualifies Δ8-THC to be a better lead compound for exploring the undiscovered aspects of cannabinoid receptors . Delta-8 THC, delta-9 THC, and delta-10 THC can affect you differently. Because of limited research, delta-10’s safety is unknown. No research exists on the medical benefits of delta-10 THC. Its mild high may appeal to you if you’re looking for something subtler than delta-9. It also interacts with receptors responsible for the intoxicating effects you feel from cannabis. Each cannabinoid interacts with different receptors in the body, giving them unique effects. Like other cannabinoids, delta-8 interacts with your body’s endocannabinoid system (ECS).

Instances of themes and subthemes were calculated across participants.
The C21 aromatic hydrocarbons are restricted in their natural occurrence to cannabis (with a few exceptions).
In 1995, researchers gave delta-8-THC to eight pediatric cancer patients two hours before each chemotherapy session.
The efficacy of these products has not been confirmed by FDA-approved research.
They utilized the GTPγS functional assay to measure the ability of Δ8-THC to activate the G protein-coupled receptors documented binding affinities of 251 nM and 417 nM against CB1 and CB2 receptors, respectively .
Conversely, another study did not find convincing proof to suggest any intrinsic pharmacological impact of the Δ8-THC on monoamine oxidase (MAO) activity .
Many participants had similar statements such as “Delta 8 is a great thing.

There’s a common misconception that delta-8 THC has less THC than delta-9 THC. Delta-8 THC can cause a similar high to delta-9 THC. This means that most delta-8 THC is semisynthetic, rather than the “natural” compound it often claims to be. Among these, some drugs such as buspirone demonstrated efficacy against cannabinoid dependence in controlled clinical trials . Modulation of the arachidonic acid pathway and the stimulation of the prostaglandin EP3 receptors may also be involved in dependence and withdrawal . On the other hand, the acute administration portion of the study identified that Δ8-THC reduced yawning induced by dopaminergic and cholinergic agonists . A contradictory study showed that a single administration of 10 mg/kg of Δ8-THC was insufficient to suppress naloxone-induced morphine withdrawal . Significant changes in rat’s defecation (potentially indicative of mood changes) and grooming behaviors (potentially indicative of withdrawal symptoms) were noted . It’s often marketed as being a natural cannabis product, but most delta-8 THC is chemically made by adding strong acids to convert CBD oil into delta-8 THC. All the products we offer are federally legal and hemp-derived. The current study provided a broad descriptive assessment of self-reported experiences with delta-8-THC. Delta-8-THC products may provide much of the experiential and therapeutic benefits of delta-9-THC with lower risks and lesser adverse effects. The current study assessed participants’ naturalistic experiences, rather than experiences with a specific delta-8-THC product. The study revealed that the symptoms observed in individuals exposed to Δ8-THC closely resemble the established effects of Δ9-THC. Impurities were identified as compounds resulting from low-quality CBD (extracted from hemp used as starting material), as well as known side reaction products from the cyclization reaction used to convert CBD into Δ8-THC. The results indicated that the tested samples contain a range of impurities in concentrations far beyond what is declared on certificates of analysis for these products. Contact us to learn more about our exotic cannabinoid testing. At ACS Laboratory, we test Delta-8, Delta-10, HHC, HHCP, and THCP for potency and chemical contaminants. Still, recent hemp industry innovations show Delta-9 may not be the most potent or desired product. Delta-9 is the most well-researched and well-understood psychoactive compound. Tests don’t care if it’s Delta-8 or 9. Delta-9 isn’t inherently addictive, but, as with any consumable, it’s important to moderate your use and know your why…maybe even give your brain and body a breather now and then. If you’re lighting up to avoid discomfort, boredom, or anxiety every single day, it’s worth asking whether it’s still serving you—or just becoming a crutch. Delta-9 is more potent, and that makes its potential for psychological dependency a bit higher. Because the widespread use of delta-8 is so new, it’s too soon to know how addictive it is. But more research is needed to understand what a standard dose of even regulated delta-8 products should be. If you do decide to try delta-8 THC, it’s best to start with a small dose to see how it will affect you. And we also need better regulation to ensure that delta-8 THC products are produced safely. But since delta-8 THC is often sold as delta-8 hemp or delta-8 CBD, this can be very confusing and misleading when you’re buying it. Participant concerns regarding delta-8-THC were generally focused on continued legal access. Participants generally compared delta-8-THC favorably with both delta-9-THC and pharmaceutical drugs, with most participants reporting substitution for delta-9-THC (57%) and pharmaceutical drugs (59%). Invitations to participate were distributed by a manufacturer of delta-8-THC products via social media accounts, email contact list, and the Delta8 Reddit.com discussion board. More recently, Correia et al. (2023) developed and validated an HPLC-PDA method for the quantification of Δ8-THC, in addition to Δ9-THC, CBD, CBN, Δ9-THCA, and CBDA in cannabis products, following an ultrasound-assisted solid–liquid extraction protocol . Additional analytical techniques, including gas chromatography-mass spectrometry (GC-MS), gas chromatography with flame ionization detector (GC/FID), and quantitative nuclear magnetic resonance (QNMR) were also reported for Δ8-THC analysis. The increasing availability of products containing Δ8-THC and its isomers, which are erroneously classified as hemp, emphasize the need for precise and accurate analytical methods to evaluate its existence and concentration in various matrices. The small difference in the chemical structure of the two isomers of tetrahydrocannabinol has a noticeable effect on the three-dimensional shape of the molecule, which may account for the differences in the pharmacological and psychological effects described . Two cannabinoids, 10α-OH-Δ8-THC, and 10β-OH-Δ8-THC, were finally isolated using a silica HPLC column, isocratically eluted with 10% EtOAc/n-hexane . WebMD says, “Other common THC side effects like paranoia, anxiety, and drowsiness are also less potent with Delta-8 than Delta-9.” Delta-8 binds to CB1 receptors less strongly than Delta-9, which is what causes that gentler high, according to pathology professors Prakash Nagarkatti and Mitzi Nagarkatti. Mentions of “THC” without a qualifier usually refer to Delta-9, found in higher concentrations in cannabis. Delta-10 products are increasingly popular, and many product types are on the market for users to vape and ingest. As a result, manufacturers can’t extract enough to make products. Delta-10, like Delta-8, appears in trace quantities in cannabis plants. Delta-10 and Delta-9 have nearly identical chemical structures with double carbon atom rings. Moreover, Δ8-THC -tolerant mice were cross-tolerant to the body temperature-lowering effects of chlorpromazine, but not to morphine or pentobarbital 173,174. Mice became completely tolerant to the hypothermic effects and partially tolerant to extended phenobarbital-induced sleeping times and catalepsy within 38 days of daily intravenous Δ8-THC administration 171,172. It is worth noting that tolerance to the biological effects of Δ8-THC has been a recurring observation in several scientific publications. Another study demonstrated the interactions in the use of Δ8-THC and opioids within intracellular systems. This suggests that the pain-relieving effects brought about by Δ8-THC do not arise from a direct interaction with the opiate receptor . In a combination study, to understand the mechanism of analgesic action, while morphine pretreatment did amplify the analgesic effect, administering naloxone to mice beforehand did not impede it. Conversely, when administered intrathecally rather than orally, Δ8-THC was reported to be less potent than Δ9-THC employing the tail-flick test . In the same study, immediately after exposure, the mixture induced a reduction in body temperature, leading to a hypothermic effect compared to exposure to the control vehicle . Substitution of delta-8-THC for delta-9-THC may be consistent with harm reduction, one of the core principles of Public Health. Participants were recruited through the social networks of a delta-8-THC and CBD product manufacturer and a delta-8-THC social media interest group. Although our results are largely descriptive, we provide an initial encouraging assessment of the suitability of the use of delta-8-THC as a possible harm reduction practice. Interventions based on harm reduction principles have been successful in reducing risk behaviors related to cannabis use, for example driving while under the influence of cannabis (Poulin and Nicholson 2005). Additionally, the Birmingham School of Medicine has reported recently a notable surge in the frequency of emergency department admissions, both in their own hospital and in several others, attributed to the utilization of Δ8-THC . In pediatric cases, the clinical manifestations resulting from exposure to Δ8-THC encompass a spectrum of effects, which extend beyond but are not confined to alterations in mental status. This study supported a prior investigation that detailed cases of two individuals, aged 19 and 20, experiencing acute psychiatric distress after consuming a Δ8-THC product. These products are not intended to diagnose, treat, cure or prevent any disease. It’s advisable, to begin with a small portion (less than a full gummy) and patiently observe the effects before deciding whether or not to consume more. At Just Delta, we offer the highest quality products.

Rather than try to extract the less than 0.3 percent of THC from a whole lotta hemp plants, companies can just extract the ample CBD from hemp and then synthesize it.
Products containing delta-8-THC became widely available in most of the USA following the 2018 Farm Bill and by late 2020 were core products of hemp processing companies, especially where delta-9-THC use remained illegal or required medical authorization.
In a short-term study regarding the cardiovascular system, a relationship between the administered dose (2 mg/kg) of Δ8-THC and a decrease in heart rate was evident.
In one study, in addition to Δ8-THC, the cannabinoids Δ9-THC, CBD, 9(S/R)-Δ6a,10a-THC, and (6aR,9R)-Δ10-THC were identified in an e-cigarette cartridge.
WebMD says, “Other common THC side effects like paranoia, anxiety, and drowsiness are also less potent with Delta-8 than Delta-9.”
The 2018 Farm Bill did not specifically address delta-8-THC, but effectively legalized the sale of hemp-derived delta-8-THC products with no oversight.
Experiences with delta-8-THC were most prominently characterized by relaxation, pain relief, and euphoria (see Table 1 and Fig. 1).
That said, delta-8 THC use has risks.

Currently, there are no federal regulations around childproof packaging, laboratory testing, or clear labeling of delta-8 products. And, because delta-8 THC isn’t a main component of the cannabis plant, it hasn’t been studied as much as CBD and delta-9 THC. Most delta-8 THC products currently being sold are manufactured without following any safety regulations. The DEA recently issued a statement that Delta-8 and Delta-9 THCO fall under the Controlled Substances act because they don't occur naturally in hemp plants. THCO is a relatively recent cannabinoid to hit the market. First, they start with hemp-derived Delta-8 or Delta-9 THC. Only two out of nine hemp concentrates analyzed contained Δ8-THC, namely one type of Δ8-THC distillate and one type of Δ8-THC hemp shatter, where Δ8-THC contents were 70.96% and 72.32% (w/w), respectively . The mobile phase composition was optimized by studying different percentages of acetonitrile and formic acid concentrations in water. In the total of four hemp samples, Δ8-THC was detected and quantified in only one sample at a concentration of 0.06% w/w . Moreover, untargeted analysis by GC-MS and LC-HRMS was performed for the determination of diluents and other cartridge components in order to further understand the occurrence of EVALI . That’s because delta-8 THC forms weaker bonds with cannabinoid receptors in the brain than delta-9 THC. The most common and abundant chemicals in the cannabis plant are delta-9 THC and cannabidiol (CBD). But Delta-8 THC is considered a minor cannabinoid because it’s only found in very small amounts in cannabis plants.

All three cannabinoids have health benefits and produce a ‘high.’ But their effects differ from one another.
The lower Δ8-THC dose (20mg) produced the least clinical effects with slower onset and shorter duration of action .
Delta-10, like Delta-8, appears in trace quantities in cannabis plants.
With a medical cannabis card from Leafwell, you can access safely made products at licensed dispensaries.
This suggests that the pain-relieving effects brought about by Δ8-THC do not arise from a direct interaction with the opiate receptor .
Also, nabiximols, in a randomized clinical trial, were utilized as a successful agonist replacement therapy against cannabinoid withdrawal .
An HPLC-MS/MS method was developed for the analysis of Δ8-THC, Δ9-THC, CBD, and 10 additional cannabinoids and their metabolites in oral fluid (including 11-OH-Δ9-THC, Δ9-THC-COOH, THCV, CBDV, cannabidiorcol (CBD-C1), CBC, CBN, and CBG .
Delta-8 may still cause side effects, especially if your THC tolerance is low.
Depending on your dose, tolerance, and the method of consumption, the effects can linger into the next day.

Additional undisclosed chemicals may be used to change the color of the final product or to increase shelf life. A recent FDA consumer warning update (2022) addressed several concerns with the chemical manufacturing process mentioned above . The cyclization reaction categorizes the resulting Δ8-THC by some scientists as a synthetic cannabinoid, thereby designating it as a controlled substance . A wide variety of Δ8-THC products are being sold on the shelves of shops, gas stations, or from online sources. Moreover, the intensity and duration of clinical effects produced by the treatment with Δ8-THC were dose-dependent. The lower Δ8-THC dose (20mg) produced the least clinical effects with slower onset and shorter duration of action . Both Δ8-THC and Δ9-THC clinical effects were evaluated by a narrative log covering every 30 min for up to 5 h with the records of pulse rate, blood pressure, and conjunctival color. Resources discussing the clinical trials on Δ8-THC are very limited; however, most of its potential benefits are dependent on marketing claims. Also, nabiximols, in a randomized clinical trial, were utilized as a successful agonist replacement therapy against cannabinoid withdrawal . The study was carried out at different pHs (4.5, 7, and 9) and temperature conditions (4 °C, 20 °C, and 45 °C) for 28 days using an Abbott Architect Plus c4000 Autoanalyzer. A summary of the analysis of Δ8-THC and its metabolites in different biological matrices is displayed in Table 1. The developed method was then applied for the analysis of Δ8-THC-COOH and Δ9-THC-COOH in postmortem urine samples. A baseline separation of Δ8-THC-COOH and Δ9-THC-COOH peaks has been achieved using GC-MS analysis. Moreover, the reported GC-MS method succeeded in the separation and quantification of both Δ9-THC-COOH and Δ8-THC-COOH as TMS derivatives using relative retention time compared to Δ9-THC-COOH-d9 as the internal standard . Depending on the type of person you are, you may or may not like the effects of some cannabinoids. But, Just like Delta 9 THC can be combined with CBD for a less psychoactive effect, Delta 8 and CBD will have the benefits of both cannabinoids with little to no high. All exotic cannabinoids must be tested for manufacturing chemicals, such as solvents, acids, and metals. Customers may prefer exotic cannabinoids due to their experience profiles, legality, and product types. Few THCP products exist on the market, but THCP uses are the same as other cannabinoids. This study compiled the self-reported experiences of delta-8-THC consumers. Similar research collaborations may accelerate the generation of knowledge regarding delta-8-THC and other cannabinoids. Current results suggest that delta-8-THC products have therapeutic benefits and typical administration routes (consumption as an edible, tincture, or by vaping) may produce less harm than smoking cannabis flower. Proportionally, participants reported the duration of effect as much more with delta-9-THC (20%), somewhat more with delta-9-THC (27%), about the same (41%), somewhat more with delta-8-THC (8%), and much more with delta-8-THC (5%). But that doesn’t mean it’s completely free from habit-forming potential. “Addictive” is one of those loaded words that needs some unpacking—especially when we’re talking about cannabinoids. Because of a legal technicality big enough to fly a whole hemp industry through. Let’s just say that cannabis has always been tied up in binary legislation that has kept its legality…dynamic. In 1995, researchers gave delta-8-THC to eight pediatric cancer patients two hours before each chemotherapy session. Its popularity grew dramatically in late 2020, gaining the attention of cannabis consumers and processors throughout the United States. Delta-8-THC is found naturally in Cannabis, though at substantially lower concentrations than delta-9-THC (Hively et al. 1966). Due to its altered structure, delta-8-THC has a lower affinity for the CB1 receptor and therefore has a lower psychotropic potency than delta-9-THC (Hollister and Gillespie 1973; Razdan 1984). Delta-8-THC differs in the molecular structure from delta-9-THC in the location of a double bond between carbon atoms 8 and 9 rather than carbon atoms 9 and 10 (Razdan 1984). These cases demonstrate a conceivable link in time between the consumption of products containing Δ8-THC and the emergence of manic or psychotic symptoms, implying a potential relationship between dosage and response . Fourthly, concerns are raised about the manufacturing process, which may involve potentially harmful chemicals and lead to contaminants in the final product. Thirdly, Δ8-THC shares similar psychoactive effects with Δ9-THC, indicating a comparable level of impairment. Firstly, these products have not undergone FDA assessment or approval for safe usage, potentially posing risks to public health. Additionally, Δ8-THC appears to antagonize oxidative stress, suggesting potential protective effects on B lymphocytes and fibroblasts. Furthermore, the absence of information on long-term studies and chronic effects of Δ8-THC use is a notable limitation, impeding a comprehensive understanding of the compound’s sustained impact. Complete prevention of vomiting was achieved with almost no side effects upon the use of Δ8-THC treatments, regardless of the antineoplastic protocol followed . The authors concluded that both Δ8-THC and Δ9-THC produce the same clinical effects when administered intravenously, however, Δ8-THC exhibited approximately 2/3 the potency of Δ9-THC, when administered orally . Cross-sector collaborations among academics, government officials, and representatives from the cannabis industry may accelerate the generation of knowledge regarding delta-8-THC and other cannabinoids. Products containing delta-8-THC became widely available in most of the USA following the 2018 Farm Bill and by late 2020 were core products of hemp processing companies, especially where delta-9-THC use remained illegal or required medical authorization. Similarly to delta-8, delta-10 is a trace cannabinoid in cannabis. The legal status of delta-9 depends on your state laws; THC products over 0.3% are still illegal at the federal level in the United States. But it attaches to receptors in your body more strongly than delta-8, so its effects are more potent.