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For assessing acid‐base balance, venous blood samples were analysed weekly for acid‐base status, electrolytes, glucose, haemoglobin, serum creatinine and urea (Abbot iSTAT® cartridges CG4± and CHEM8±, Abbot Point of Care Inc). During weeks 2–5, participants were asked to measure out 25 ml (25 g) of the ketone monoester in a measuring cup and drink it either neat or diluted with the zero calorie artificially sweetened drink of their choice, three times daily. Given the metabolic and physiological peculiarities of this disease, and the potential benefits of exogenous ketosis on glycaemic control, we aimed to study the safety and tolerability of the KE in patients with T2D.