Applied directly to the skin, it allows for the gradual absorption of testosterone into the bloodstream, helping to restore normal hormone levels. Testosterone cream is a topical treatment option for men with low testosterone levels. This method provides a steady release of testosterone throughout the day, helping to maintain more consistent hormone levels. However, it should be taken into account that physiologically testosterone levels are lower with increasing age (see section 4.4). The recommended starting dose of Testavan is 23 mg testosterone (one pump actuation) applied once daily. One pump actuation delivers 1.15 g (1.25 mL) of gel equivalent to 23 mg of testosterone. There were three studies 20,31,32 in which blinding methods were conducted as single blind. All studies described randomized methods and reasonable intention-to-treat analysis. There were several different formulations, including patch , gel 16,18,19,26,27,28,29,31, IM 17,20,21,25,30,32, and PO 14,23,24. For outcome measurements, several different outcome measurements were used for sexual function, including IIEF 22,25,27,28,29,30,32, AMS , and self-scale 14,15,16,19,20,23,26,31. All studies were randomized controlled placebo trials conducted in Western countries except for Brill et al and Chiang et al 14,22. In patients with a certified diagnosis of primaryor central hypogonadism and in those with suspected constitutional delay ofpuberty and no testicular volume enlargement, the androgen dose is increasedprogressively in increments of 50 to 100 mg every 6 to 12 months. Indeed, treatment with low doses oftestosterone in boys with constitutional delay of puberty provokes a slowerincrease in testicular volume than in untreated boys (Bergadá & Bergadá, 1995; Chioma et al.,2018). Usually referred toas “induction of puberty,” androgen therapy actually induces in thesepatients peripheral pubertal changes but not the reactivation of thehypothalamic–pituitary–testicular axis. Androgen therapy is used in patients with a known condition warrantingpermanent hypoandrogenism (anorchidism, congenital central hypogonadism,etc.) and in those with constitutional delay of puberty. This takes place in the genital skin and prostate in males and in the skin in females. As an adult, your body converts about 10% of your testosterone (the main androgen) into DHT each day. DHT affects the sexual development of males throughout their lives, beginning as early as in fetal development. When DHT levels are too high or too low, it can cause different issues depending on your age and stage of sexual development. Remember, always consult a doctor before purchasing any medication or beginning any treatment. Testosterone injections are arguably the most reliable form of treatment, however modern creams should be considered if you would prefer a non-invasive dosing method. Testosterone creams have significant advantages over gels and can be a great choice for people who want to avoid injections. Managing Electrolytes for Optimal Bodily Functions Dihydrotestosterone is applied externally so it should not react with any other medicines. People who are hypersensitive to Dihydrotestosterone or its excipients (Carbomer 934, triethanolamine, Alcohol 95%) should discuss using this medicine with their doctor. The gel should be left to dry for five minutes or so before putting on clothes. This is not true in the case of T and estradiol, in which a ratio has abiologic rationale given the opposing action of these hormones in most tissues. Although reassuring with respect to DHT, this study was small and thusconfirmation in a larger trial would be beneficial. Median serum concentrations of androstenedione and Twere significantly elevated in women with PIH vs controls. Some less common routes are androderm patches, injectable testosterone undecanoate, and testosterone pellets. Before and after images of hair transplantation are the first things that people who are considering hair transplantation are curious about. Hair transplant Turkey before and after are the first things that people who are considering hair transplantation are curious about. Watch our video to examine dozens of hair transplant before and results. They have limited tissue-selective antiandrogenic effects, for instance in skin and hair follicles. This is achieved by suppressing testosterone levels and increasing estradiol levels such that they are both within normal adult female ranges. Despite the fact that they do not identify as either male or female, many non-binary transmasculine and transfeminine people pursue hormone therapy just like transgender men and women. This medicine may increase the risk of prostate cancer, especially in older males. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. I could be wrong but I believe it was $2000 for the 4-5 session therapy and you have to cover the costs of the tests he runs. The problem is he charges an insane amount for therapy with not a lot of positive result. Thanks @Milando97, to be clear - no doctor has the slight clue what’s going on, hence the multiple studies leaving us just holding our flaccid dicks in hand. I’ve seen very very good reviews on this forum and others about the Oxandrolone given that it is low level steroid that has very good affect and low side effects. Dihydrotestosterone (DHT) is a potent androgen that is critical for male genital development, which when applied topically, has been shown to increase penile length with micropenis of varying etiologies. Topical dihydrotestosterone to treat micropenis secondary to partial androgen insensitivity syndrome (PAIS) before, during, and after puberty - a case series. In this study, we confirmed that testosterone replacement in elderly patients might not significantly improve their sexual function. In light of the fact that low androgen levels have beenidentified in men (and women) with dementia and Alzheimer’s disease (216, 217), further large,placebo-controlled studies are of value to determine whether DHT has any effect inmaintaining cognitive health. The mechanism for this relationship is unknown, but it is possible thatlow circulating androgen levels lead to detrimental effects on cognitive function. The cognitive effects of androgens have been difficult to ascertain, and there are fewstudies that have specifically focused on the role, if any, of DHT on cognition in men orwomen. In fact, a biochemical definition of female androgen deficiency is not completely reliable, because of the lack of standardized, accurate assays for androgens at the low levels characteristic of women and, as well, the lack of valid reference ranges . Your prostate size and strength is affected, as well as it’s ability to produce the hormones needed for libido and sexual appetite. People who are hypersensitive to andractim 2.5% gel or its ingredients should discuss using this medicine with their doctor.What are the side effects? Typical guidance is that maximum growth is reached in the first year to three years, but this depends heavily on the individual and their T route and dosage. For some, bottom growth is one of the first changes noticed while on T for their gender transition. They can order tests and recommend treatments that may help. Goglia et al. (105) showed that physiologic doses of T and DHT given to normal orovariectomized Wistar rats in vivo or in human aortic endothelial cellcultures in vitro increase the synthesis of nitric oxide through eNOSphosphorylation via the ERKPI3K/AKT pathway. Here we briefly review existing in vivo animal data or endothelialcell culture experiments that explore the role of androgens (most notably, DHT) onendothelial cell function. “Alternate synthetic pathways may have particularclinical significance within prostate tissue.” Inlight of the fact that this study was not powered for CV outcomes, these findings alsomerit confirmation in a larger, well-controlled trial. People with this condition have normal testes with normal to high testosterone levels — they just lack androgen receptors. It happens when their ovaries create excess androgens, including testosterone, which leads to increased DHT levels. High levels of DHT can shrink your hair follicles and shorten the hair growth cycle, resulting in hair loss. During male puberty, DHT promotes further growth of the penis and scrotum. During fetal development, a specific and unique environment of hormones results in male or female differentiation of sexual anatomy. Although finasteride anddutasteride both can cross the blood-brain barrier (210, 211), the predominant expression ofSRD5A type 1 in the brain makes dutasteride a better agent for studying the effects of DHTinhibition in humans on cognition and mood. Alternatively, cognitive decline may be adirect cause of a reduced androgen status, a hypothesis that is contradicted by the factthat cognitive decline is not a hallmark of longstanding male hypogonadism (205). Othershave reported that treatment of men with mild cognitive impairment and low T may benefitfrom T replacement therapy and that aromatization of T to estradiol is critical forimprovement of verbal but not spatial memory (203,204). Additional,and appreciably larger, studies are needed to more fully determine the clinical utilityand safety of DHT-hp in the nonsurgical treatment of gynecomastia. However, only one of these DHTpreparations is commercially available (i.e., DHT gel) in a small numberof countries, excluding the United States, and none have been evaluated for 5ARD inlonger-term efficacy and safety studies. FTM Bottom growth can be helpful by DHT gel.In this section, I’ll discuss androgen deprivation largely from the standpoint of efficacy.These patients exhibit a wide range of genital ambiguities, from apparent male external genitalia with mild under-masculinization to complete female external genitalia.This unique formulation allows for targeted treatment of specific conditions and potentially fewer systemic side effects compared to other testosterone preparations.It is important to note that this collection of studies involves low event-rate randomized binomial trials.This points to a weakness in some studies of TRT or SRD5A inhibition, namely,the absence of data on circulating DHT levels.While results may vary among individuals, consistent use and combining it with other hair growth strategies can improve outcomes.In studies that did not report standard deviation, we applied an estimate of pooled standard deviation of two groups. This is a commercially offered topical gel that delivers DHT when utilized to the skin. This pain of having an inadequate penis dimensions will proceed all through your daily life except if you determine to do a thing about it. It looks like your penis is a bit bigger. The product is made for trans men and cis man who have a small penis. Hello,Thank you for your follow-up.No, DHT supplementation or Andractim gel will not reduce your intrinsic DHT levels, after you stop using it. Maintained for minutes, this can stimulate the growth of new DHT receptors in the penis’ spongy tisssues. (According to research, penile growth cessation is controlled by mechanisms other than down regulation of androgen receptors.) With ballooning, penile tissues are literally soaked in DHT-enriched blood. Those that remain are sensitive to testosterone stimulation and may respond to PE programs that include DHT gel and penile ballooning. Because most events clustered into the midnormal DHT range with few events at lowor high DHT levels, use of a curvilinear model was required that resulted in wide CIs atlow and high DHT concentrations. The authors noted that acausal relationship between DHT and CVD could not be determined and that prospectivestudies are needed to confirm these results and to clarify the underlying physiologicmechanisms. However,most events clustered into the midnormal DHT range with few events at low or high DHTlevels, thus necessitating the use of a curvilinear model that resulted in wide confidenceintervals (CIs) (Fig. 5). DHT has at least three times the binding affinity for SHBG than testosterone. Androgens circulate in the blood bound to proteins, especially sex hormone binding globulin (SHBG) and albumin. The bulk of androgen production takes place mainly in the Leydig cells of the testes. It is likely these effects are mediated by a reduction in intraprostatic androgen concentrations because 5α-reductase inhibitors lower both serum and intraprostatic concentrations of DHT considerably (12, 13). Approximately 5% of circulating T is converted to the more potent androgen dihydrotestosterone (DHT) by the enzymes, type I and II 5α-reductase. An improved understanding of the hormonal and molecular consequences of androgen manipulation within the human prostate might help guide future trials designed to assess risks and benefits of these hormonal therapies. Low testosterone levels can also be the result of changes in parts of the brain that are responsible for testosterone production. Low levels of testosterone can also be attributed to physical damage to the testicles. The levels of testosterone naturally begin to fall once a man is around the age of forty. Digital tEchnology For Lung Cancer Treatment PSA velocity of more than 0.4 ng/ml/year, using the PSA level after six months of testosterone administration as the reference, requires further urological evaluation. PSA increments of ≥1.4 ng/mL above baseline in any one-year period should warrant urologic evaluation and consideration of prostate biopsy. Initial monitoring for symptom relief (improvement in libido, erectile function, energy and well being) should be performed three months after initiation of therapy. Even though there is paucity of cases reporting inter-personal transfer, the risk of transfer to women and children is possible. Oral, transdermal, and subdermal testosterone preparationsand oral oxandrolone have only been explored in a few clinical trials. In pediatrics, IM testosterone is the prevailing therapeutic agent, with specificuses for topic DHT. However, evenif their androgenic action is low, these agents may impact on precociousgenital development (Davis et al., 2018). In boys and adolescents with Klinefelter syndrome,oxandrolone has been used with apparently positive effects oncardiometabolic health markers (Davis et al., 2017) andvisual–motor and psychosocial functions (Ross et al., 2017). Hepatocellular neoplasia and hepatic peliosis have beenreported in association with long-term therapy. Measurements of prolactin and iron studies are also important aspects of evaluation.This is a synthetic version of the hormone of testosterone.Data in rats have shown increased incidences of prostate cancer after treatment with testosterone.During adolescence and adulthood, androgens exert their actions on many organs,other than the testes themselves as already discussed.Some people say only small doses are needed.Where the spray focuses on moisture, the gel delivers concentrated healing compounds directly to tissue.However, while DHT transdermal cream is widely recognized as the most appropriate treatment option for the pathophysiology of patients with 5αRD2, its effect on height was not adequately evaluated. Of 43 screened subjects, 32 met criteria for randomization and enrollment, and 28 completed study procedures. Because hormone results were nonnormally distributed, nonparametric statistics were performed using STATA version 10.0. The percentage of Ki-67–positive cells per 100 epithelial cells was assessed by two individuals blinded to treatment group and averaged (24). Frozen prostate biopsy cores were used for laser capture microdissection, RNA isolation and amplification, and microarray hybridization as previously described, using 44K whole human genome expression oligo-microarray slides (Agilent Technologies, Inc., Santa Clara, CA) (22). Individual core concentrations for each androgen were averaged for each subject. These findings raise thepossibility of some androgen selectivity, although a potency or aromatase effect could notbe ruled out (207). In rodents, T but not DHT improves workingmemory in aging male rats (206), whereas in femalerats, T and DHT improved different aspects of cognition. For this very reason,transdermal DHT (199) and a parenteral DHT prodrugDHT-heptanoate (DHT-hp) has been explored as a treatment of spontaneous gynecomastia inmen or adolescent boys (198, 200). Parenteraladministration of DHT heptanoate (DHT-hp) at 4- to 6-week intervals that resulted in asustained elevation of plasma DHT levels has also been used in the clinical management of5ARD (198). Treatment of 5ARD with transdermal DHT preparations thatincreased circulating DHT to adult levels has been reported (196, 197). JFY participated in study conception and design and in revisions of the manuscript. SEB participated in study conception and design, performed searches, contacted authors for additional information and drafted the manuscript. Quality assessment for trials reporting elevation of serum T and DHT following TRT. However, our data indicate that transdermal TRT produces a significantly greater elevation of serum DHT than intramuscular T, possibly due to the expression of 5-alpha reductase in the skin. This early indicator that intramuscular T may be safer than transdermal TRT may be surprising, considering that intramuscular TRT doses are typically several-fold higher than transdermal doses. Patients with 5αRD2 typically present with vulvas and varying degrees of hypospadias, clitoromegaly, or microphalli; phenotypes that are either mostly male or female are rare .All study procedures took place at the University of Washington Medical Center, Seattle WA, and were approved by the University of Washington Institutional Review Board.Testavan provides transdermal delivery of testosterone, with a median Tmax of approximately 2-4 hours after dosing.Androgen action in the masculinization programming window and development of male reproductive organs.The result is natural – our patients gallery can give you an idea of what to expect.However, basalAMH and inhibin B production remains active throughout childhood (Valeri et al., 2013).Germ cells proliferate by mitosis but do not enter meiosis; thus, spermatozoaare not produced (Edelsztein& Rey, 2019; Makela et al., 2019), owing to the low levels of intratesticulartestosterone during childhood (Rey et al., 2009).Pumpkin seed oil, for example, is rich in zinc, which is important for normal prostate function. Effect of different treatments for female sexual dysfunction on clitoral artery PSV. Total testosterone levels according to the mean frequency of sexual events in sexually active women treated for FSD. In contrast, despite the clinical evidence and the current consensus on the central effect of T on female sexual desire 3, 18, the mechanisms by which androgens may directly act in relevant female brain areas have not been elucidated . Eligible participants were patients aged less than 18 years old, who underwent a complete physical examination and etiological investigation to rule out the other etiologies of micropenis. All enrolled patients had complete medical records and gave their oral consent to participate in this study. The diagnosis must be made early in life to ensure that appropriate androgenic treatment can be initiated as soon as possible to avoid the psychological consequences which are sometimes dramatic. Major market drivers encompass increasing consumer awareness of silica's role in keratin synthesis, aging demographics seeking hair maintenance solutions, and the proliferation of professional salon-grade treatments. However, anecdotally, we have heard from people who weren't on T for a long time, were on low doses, or didn't have a large amount of growth, that bottom growth reverted completely (or almost entirely) after stopping T. If someone is experiencing bottom growth that feels excessive or rapid, they can adjust to a lower T dosage to manage these side effects. Masculinizing changes can be noticed within the first year of T gender-affirming hormone replacement therapy. During this period, using DHT-blocking shampoos and growth-promoting products helps maximize your results. Crown transplants often take longer than hairline work. The new hairs may look thin, wiry, or different in texture. The Baylor study should hopefully (praying) shed some true light on this, but when asking Dr. Goldstein, he seemed very reluctant in thinking the study is going to really blow up the thinking on our syndrome, and prove some new insight - particularly to the point that we are able to find a cure. So it would show levels as being fine, but in fact the test is actually measuring a frankenstein form of what it’s actually trying to test. The problem here is that blood tests might show certain DHT levels (and even the rare test of 5ar reductase levels) - BUT the test is actually seeing an incorrectly ‘built’ DHT or 5ar enzyme. The altered Allo levels cause a bunch of issues with GABA and the ability for the brain to calm and relax itself, as well as having links to dopamine which affect libido, motivation, and pleasure. DHT is responsible for the smooth muscle wall of the penis, and when that gets damaged you lose your penile structure. These enzymes(expressed in the nucleus and cytoplasm of, for example, prostate epithelial cells) (10) are encoded by the 5α-reductasetype 2 (SRD5A2) gene, and polymorphisms of this gene (leading to increased5α-reductase activity and DHT concentrations in prostate) have beenhypothesized to increase risk of prostate cancer (11). Localization of SRD5As inprostate tissue (type II), skin (type I), liver (types I and II), and hair follicles(primarily type I) catalyzes the formation of DHT from T in these tissues. Our review is focused primarily on DHT actions in men given historical concern aboutpotential adverse effects of elevated DHT on prostate. This points to a weakness in some studies of TRT or SRD5A inhibition, namely,the absence of data on circulating DHT levels. In adult eugonadal men, serum DHTlevels are about one-tenth that of total serum T concentrations. Before and after assessments in trials often show measurable improvements in hair thickness and density over periods typically ranging from 3 to 9 months of use. The Asia-Pacific region, however, demonstrates the fastest growth rate, driven by expanding middle-class populations and increasing beauty consciousness. This trajectory is fueled by rising consumer demand for scientifically backed solutions addressing hair thinning and loss. Valued at approximately $1.8 billion in 2023, projections indicate a compound annual growth rate (CAGR) of 7.2% through 2028. Data in rats have shown increased incidences of prostate cancer after treatment with testosterone. Toxicological studies have not revealed other effects than those which can be explained on the base of the hormone profile of Testavan. Circulating testosterone is chiefly bound in the serum to sex hormone-binding globulin (SHBG) and albumin. Rapid Acceleration of Diagnostics - Digital Health Technologies (RADx-DHT): Large Scale Flu Surveillance Study (LSFS) Call your doctor for medical advice about side effects. If you notice any other effects, check with your healthcare professional. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Some side effects may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Women with a total score lower than 26.55 are classified as being at risk for FSD. Briefly, we asked participants to abstain from sexual activity, including masturbation, for at least 12 h before examination, and to void their bladder immediately before to guarantee standardized conditions. Finally, all patients underwent a CDU as well as biochemical and psychometric evaluation. Additionally, body weight, height, body mass index (BMI), waist circumference, systolic and diastolic blood pressure were registered to evaluate the metabolic status and the presence of cardiovascular (CV) risk factors. In hypogonadal men, the use of T replacement therapy (TRT) is currently well established and it is strongly recommended to induce/maintain secondary sex characteristics and to correct symptoms of T deficiency . The fact is that many use finasterid without any side effects.We examined not only studies in which elevatedDHT was documented, but also those where 5AR-Is were used to suppress DHT production.It prevents your hair from various causes that damage your hair to a great extent.Human AR mutants were expressed in COS-1 and HeLa cells to investigate hormone binding, transcriptional activation, and subcellular localization.Prostate weight and prostate-specific antigen levels did not change during the treatment.For genital growth, a 10% DHT concentration, non-alcoholic cream is desired. Thus, improvement in mood (similar to sexual function) in response to testosterone therapy appears to be dependent on reaching a threshold of serum testosterone that lies in the low normal range. The improvement in mood was observed on day 30 and was maintained with continued treatment for six42 and 36 months.26 The improvement in mood parameters was not dependent on the magnitude of increase in serum testosterone levels. Improvements in sexual function and libido were also evident in another three-month study of 208 patients.27 Both doses of Testim (5 g/day and 10 g/d) produced improvements in spontaneous erections, sexual desire, and performance. Increasing serum testosterone levels to the upper normal range does not further improve sexual function. Measurements of prolactin and iron studies are also important aspects of evaluation. The third step in the diagnostic evaluation is to determine whether androgen deficiency is the result of a primary testicular dysfunction or secondary to a hypothalamic or pituitary disorder. The second step is the measurement of total testosterone level, preferably in the morning, using a reliable assay. Androgen deficiency is a clinical syndrome complex that comprises symptoms and signs in conjunction with biochemical evidence of testosterone deficiency. However, the application of testosterone gel at four sites resulted in an area under the curve of testosterone which was 23% higher compared to application of the same amount of gel at one site (although this difference did not achieve statistical significance). By the end of 1st day, the levels attained were comparable with the subsequent steady-state pre-dose levels on the 3rd, 5th, and 7th days of application. It is recommended that testosterone gel be applied early morning on intact dry skin over the shoulders, upper arms or in case of Androgel, the abdomen as well. Serum testosterone levels should be monitored serially to ensure proper dosing. Testim gel is available as a single dose (tube) containing 5 g of the product. Stanolone Powder Pure Raw Material DHT Andractim Gel Active Ingredient While dedicated research is lacking, related studies and anecdotal accounts suggest that DHT is a safe and promising treatment. Absorption of dihydrotestosterone (DHT) after its intramuscular administration. …percutaneous DHT administration is a relatively safe modality of androgen replacement therapy as far as atherogenicity is concerned. DHT leaves a waxy substance at the root of hair follicles on the scalp that can inhibit hair growth. For existing FOLX members with questions about testosterone gel, don't hesitate to schedule time with a clinician. Testosterone gel is applied by rubbing the dose directly from the pump bottle onto the skin. FOLX provides testosterone gel in a pump with varying strength and volume to allow for the best care plan for each person. Overview of the effects of DHT on various pathways in adipose tissues.+ indicates upregulation, and – indicates downregulation of groupedgenes. Long-term transcriptonomic effects of DHT exposure on various genes in murine adiposetissue have been reported, but these effects have not been evaluated in humans (170). Given the androgenic potency of DHT, particularly in adipose tissue where theequilibrium of several key processes (e.g., adipocyte differentiation,lipid accumulation, and lipolysis) are directly influenced by androgens, it is temptingto reason that changes in circulating DHT may affect these processes. These findings are consistent with those ofGruber et al. (166), whoreported that transdermal DHT treatment of postmenopausal women significantly reducedtotal body and abdominal fat when assessed by dual x-ray absorptiometry. How Prostate Gel Works At steadystate, these products all yield an average serum T concentration that is roughly themidnormal range (70, 71). Given the age of the study population and duration offollow-up, this frequency was not substantially different than the general populationtreated with TRT. Numerous transdermal preparations of T are available for the clinical management ofhypogonadal men and include a nonscrotal T patch, T gel preparations of various Tconcentrations, and a T solution applied to the axilla. Only if the sum of T plus DHT were to fall abovethe upper limit of normal for the combined T plus DHT androgen concentration would there bea theoretical safety concern. In such cases, endogenousproduction of T will be suppressed but the total androgen status can be gauged bymeasurement of T plus DHT (103). DHT therapy has also shown some promising results in the treatment of micropenis , as DHT is responsible for a lot of male development during puberty. I know that this amount of andractim will cause significant growth without systemic effects such as excess hair and voice changes. Other exceptions to the classical protocols of androgen therapy are patientswith partial androgen insensitivity, who may need personalized dosage (Wisniewski et al.,2019), or patients with defects in 5α-reductase, who are deemedto respond better to DHT treatment (Becker et al., 2016; Xu et al.,2017). However, although hypoandrogenism has not been unequivocallyobserved in boys with Klinefelter, treatment with oxandrolone showedimprovements in their behavior, cognition, and visual and motor capacities.Oxandrolone was administered orally at a daily dose of 0.05–0.06 mg/kg for24 months to patients aged 4–12 years in placebo-controlled trials. Peak levels in serum occur within 30–40 min and half-lifeis short, requiring two pumps of 5.5 mg of testosterone each per nostrilthree times a day, that is, a total dose of 33 mg daily in adults. Interpretation of the data on TRT-induced elevations of T and DHT may be limited by the fact that DHT was assayed by several methods in the included studies. Variation may result from the fact that serum T concentrations are not sustained following oral TRT and the time of blood acquisition is therefore critical. The latter study was not included in the analysis of TRT-induced elevations of T/DHT because DHT was not measured. Andractim gel is a specialized form of testosterone replacement therapy that has gained popularity for its unique properties and targeted effects. This diagnosis led him to explore treatment options, including testosterone replacement therapy like Andractim gel. Andractim gel stands out from other testosterone treatments due to its active ingredient, dihydrotestosterone (DHT), which is the most potent form of testosterone. In this study, androgen receptor (AR) and estrogen receptors ER and ERß were visualized by immunohistochemistry in adult male ... Serum DHT levels are dependent upon the concentration of serum T achieved with TRT and theexpression of normal levels of functional SRD5A in tissues. Furthermore, it is well documented that DHT can be synthesizedin androgen-sensitive tissues such as prostate from substrates other than T(e.g., from 17-hydroxypregnenolone and 17-hydroxyprogesterone in what istermed the “backdoor” pathway and from 5α-androstane-3α,17-β-diol via the intracrine reverse synthesis pathway) (4). Inhibition ofthese enzymes with 5α-reductase inhibitors (5AR-Is) decreases intratissue DHTlevels and thus, in certain tissues (i.e., prostate), diminishes the agonistaction of T, thus reducing prostate size and function. Intracellular DHT is a more potentandrogenic agonist than T, and its presence in some tissues such as the prostate is necessaryfor the full organ development and function. DHT is the 5α-reduced metabolite of testosterone (T) that is principallyconverted from T in target organs such as prostate, skin, and liver. This is mainly used for children and hormone deficiencies. The full meaning of DHT is Dihydrotestosterone. This is only possible if you have at least 2 cm or are on testosterone. There are many trans guys who shared their bottom growth by FTM Pump. 💪 Treatment of Testosterone Deficiency in Men with Andractim Gel This causes a variety of symptoms, including irregular periods, excessive hair growth (hirsutism) and acne. Androgenic alopecia is commonly known as male pattern hair loss. People who have prostate cancer usually have an increase in DHT levels. This local DHT production stimulates normal prostate activity but also commonly leads to prostate growth. Prior to initiation of testosterone replacement therapy, all patients must undergo a detailed examination in order to exclude a risk of pre-existing prostatic cancer. The serum testosterone level should be measured 2-4 hours after dosing approximately 14 days and 35 days after starting treatment or after a dose adjustment. To ensure proper dosing, serum testosterone levels should be periodically measured and dose titrated to maintain eugonadal serum testosterone levels (see section 4.4.). But the part that didnt make sense, you said it wont affect my Testosterone levels after i finish cycling but the article states The extremely high serum levels of DHT achieved in this study lead to significant gonadotropin suppression, thereby reducing circulating testosterone levels to nearly castrate levels and reducing circulating estradiol levels by 90%. According to the World Professional Association of Transgender Health (WPATH), transdermal testosterone achieves the same masculinizing effects as injectable testosterone, though the time frame differs. The gel is applied to and absorbed through the skin (transdermal) and can induce more gradual changes than injectable testosterone. The best option depends on individual hair loss severity and tolerance to treatment. Always consult a dermatologist or trichologist before starting a new hair loss treatment. While results may vary among individuals, consistent use and combining it with other hair growth strategies can improve outcomes. There is debate regarding cases of prostate cancer that are detected in trials involving long-term testosterone administration. The third subject was 53 years old and had a biopsy 60 days post-treatment because of an asymmetrical prostate on digital exam. Mean international prostate symptom scores (IPPS) were not increased in subjects on gels. DHT creams like androstanolone and stanolone are primarily used to treat hormone deficiencies in children.About 10% of testosterone in the bodies of both women and men is converted into dihydrotestosterone and a much greater amount in puberty.For a hair transplant to work, you’ll need a lot of density in your donor area.While serum T and E2 levels were sustained as healthy adults, T/DHT ratios remained higher (16–21) than normal (9–15), reflecting impaired 5α-reductase type 2 activity.The local tolerability of testosterone gel is superior to other transdermal products.Some people on T will also take finasteride (or dutasteride) to keep bottom growth minimal.Moreover, we performed quantitative RT-PCR for several well known androgen-regulated genes (androgen receptor, FKBP5, NKX3.1, PSA, ACPP) and found no differences in expression of these genes between the two groups (data not shown). 🧠 The Link Between Testosterone Deficiency and Erectile Dysfunction Thesefindings demonstrate that circulating levels of DHT (in this case at the very low end) arenot reflected by intraprostatic levels. Analternate explanation is that SRD5A is so finely modulated that intraprostatic DHT levelsonly fall when the substrate (i.e., T) is very low. In addition, someDHT may enter the prostate if it is bound to SHBG because megalin on prostatic cells canbind SHBG and transport the DHT-SHBG complex into the cell (28). The prostate also canmetabolize DHT to inactive glucuronides by various irreversible pathways (see Figs. 1 and 3). After the DHT treatment, prostate volumes are apparently small in Pt. Furthermore, several clinical studies showed that DHT supplement for middle-aged volunteers does not make remarkable changes in the external genitalia 16, 17, compatible with the age-limiting effects. Consistent with this speculation, the second course of DHT treatment can not produce sufficient catch-up on penile growth in Pts. (Whether their advanced age is a factor here or not is uncertain but could be involved however.) Hence, any person who was assigned male at birth should, generally speaking or on average, not necessarily expect a marked degree of breast development. Due to these health risks, breast irradiation for prevention of breast development is an inadvisable option. Research has found a 100-fold higher incidence of breast cancer in young women whose breasts were exposed to radiation during childhood as a consequence of radiotherapy for cancer when compared to other young women (Zacharin, 2010). More concerningly, there is a theoretical increased risk of breast cancer with exposure of the breasts to radiation (Aksnessæther et al., 2018). Collectively, interplay between the N-terminal region and LBD of rAR results in the formation of a transactivation complex that includes coregulators and that is mandatory for optimal activation of androgen-induced promoters. CBP or F-SRC-1 not only enhanced AR-mediated transactivation, but also facilitated the androgen-dependent interaction between the N-and Cterminal domains, implying that part of the coactivatordependent transcriptional activation occurs via this mechanism. Consistent with this idea, a strong androgen-dependent interaction between the N-terminal region and LBD was demonstrated in a mammalian two-hybrid system using GAL4 and VP16 fusion proteins. The activity of the N-terminal transactivation domain is thus controlled by the hormone-occupied LBD, suggesting that the N-and C-terminal regions of rAR communicate. Estrogens produce feminization, including breast development, while testosterone suppression causes demasculinization—as well as disinhibits feminization. The relevant hormonal changes are accomplished through the administration of hormonal medications including estrogens, progestogens, and/or antiandrogens. No studies with the goal of partial hormonal transition in transgender people have been conducted as of present and there is no data or evidence in non-binary people to inform the use of such approaches. There is currently a discordance between the number of people who desire non-conventional hormonal transition and the clinical establishment of such therapy. Moreover, there are no available standards or guidelines for such therapy at this time. Please post on hairloss sites if you plan on continuing the medication despite your issues. The gel is artificial DHT, and the tablets are as close to artificial DHT as you get orally. You have two options; Andractim (gel) and Proviron (tablets). Ask your doctor for androgenic steroids if you don’t already have. Bottom growth varies widely from person to person. In addition,International Prostate Symptom Scores (IPSS) remained unchanged in men treated with DHTgel for 6 months. Data regarding the clinical impact of sustained supraphysiologic concentrations of DHT inmen repeatedly exposed to daily transdermally administered DHT gel provide valuable clinicalsafety information. Findings from studies in which DHT and DHT/T ratios were reported based onLC-MS/MS are more informative and should be afforded more weight. Prior to the advent of LC-MS/MS for measurement of DHT, less-precise direct DHTimmunoassay methods were used in older studies e.g., directradioimmunoassay (RIA), enzyme-linked immunosorbent assay (ELISA). Splanchnic tissues have a high capacity to metabolize DHT toDHT-glucuronide, which has importance when oral androgens like T undecanoate (TU) areadministered (46). Observationsfrom numerous clinical studies are consistent with current knowledge that androgen-sensitivetissues can self-regulate tissue DHT levels by downregulating its synthesis and upregulatingmetabolism during DHT excess or, conversely, upregulating synthesis and downregulatingmetabolism under conditions of T or DHT deprivation. Circulating levels of DHT in response to TRT do not correlate with those found inandrogen-sensitive tissue (e.g., prostate, adipose, muscle) due to localregulatory mechanisms that tightly control intracellular androgen homeostasis. After 28 days of oral TU administration at a dose of 316 mg TU, BID(equivalent to 200 mg T, BID), the average serum DHT levels increased from a baseline of21 to 110 ng/dL (0.7 to 3.8 nmol/L), and the serum DHT/T ratio increased from 0.09 toapproximately 0.3. The effects of subcutaneous T pellet implants on DHT have been evaluated in asingle-dose, open-label, nonrandomized pharmacokinetic study (76). As with other parenteral TRT products, outcome studies toprospectively assess TRT risk on prostate remain elusive. Tribulus is an herb with a documented ability to stimulate lutenizing hormone (LH) in men, much the same as clomid. Interesting, No side effects what so ever. There is a long list of possible side effects so do your research! I’m not going to get into the pro/con side effects right now. If your unfamiliar with it, its a topical steroid/hormone used to treat Gynecomastia, Micro-phallus. Before taking any new medication – including a DHT cream – it’s best to know what side effects may occur. It’s primarily for children who have problems with sexual development and can be prescribed by a doctor for this purpose. So, to put it plainly- no, you should not use a DHT cream for hair loss. Although a causal relationship between hypogonadism and erectile dysfunction has not been established , it is true that testosterone levels in adult males gradually decrease after age 40 . The search used keywords of ‘aged’, ‘male’, ‘sexual behavior’, and ‘testosterone’. I’d rather use the andractim, as that is what restored sexual function in the rat studies I saw. I’ve been googling for days now but I only see generic dht gels, and i haven’t seen studies backing those up, nor do i trust their efficacy/composition. 2.Squeeze the required amount of gel onto the spatula included in the package. The gel should be left to dry for five minutes or so before putting on clothes.1.Put on a pair of gloves. Andractim 2.5% gel is for external use only. It is available as a 2.5% gel under the brand name Andractim®, which is imported from abroad. It works by correcting the hormone deficiency, either in a particular part of the body or affecting the body as a whole. DHT and prostate cancer Proven benefits for older men with low testosterone (T) levels include increases in muscle strength, exercise capacity, bone mineral density (BMD), libido and insulin sensitivity 2,3.This is only possible if you have at least 2 cm or are on testosterone.One study found that the discomfort some people experienced with bottom growth resolved after six months of treatment.Finally, for the assessment of changes in orgasmic performance we did not use the unique psychometric tool validated to measure differences in intensity of female orgasm .The conformational change of the androgen receptor begins when the androgen molecule binds to the receptor, which subsequently homodimerizes and it is actively translocated to the nucleus.During the DHT treatment, height SDS for BA increased or remained similar, whereas TE treatment resulted in a decrease in height SDS relative to BA.For some transgender men, testosterone therapy may not sufficiently masculinize facial features.Results are reported as estimated PSV value and 95% confidence interval at baseline and at 6-month visit in the four treatment groups. Despite such high serum DHT levels, DHT gel treatment did notsignificantly increase total, central, or peripheral prostate volumes, as measured byultrasonography, nor was serum prostate-specific antigen (PSA) elevated. Transdermal dihydrotestosterone therapy and its effects on patients with microphallus. Andractim gel, with its unique composition of dihydrotestosterone (DHT), has several specific indications in the field of androgen therapy. Andractim gel, a powerful topical testosterone treatment, has been gaining attention in the world of men’s health and hormone therapy. Low Testosterone Levels Saw palmetto extract blocks DHT at the scalp level, protecting both transplanted and existing hair from hormonal damage.Although only a small proportion of T (~0.2%) is converted to estradiol, the potency of estradiol is approximately 100-fold higher than that of T , which can lead to a potential advancement in bone age (BA) with TE treatment.All content is for informational purposes only and is not a substitute for professional medical consultation or treatment.This is because estradiol is produced from testosterone and hence androgen deprivation results in estrogen deficiency as well.Despite data implicating DHT as important in the pathophysiology of benign prostatic hypertrophy, long-term follow-up of men taking oral testosterone undecanoate, which also raises serum DHT well above the normal range (29), have not demonstrated an increase in serum PSA or prostate-related adverse events (30).In any case, for the preceding reasons, a given individual could self-monitor their breast development, and, if it becomes too much for their liking, alter their medication regimen as desired in order to prevent further or reverse existing breast growth.There are published reports of increased risk of sleep apnoea in hypogonadal men treated with testosterone esters, especially in those with risk factors such as obesity or chronic respiratory disease.Most (40%–60%) circulates bind to sex hormonebinding globulin (SHBG), 33% to albumin, and 1%–4% is unbound. Hence, androsteroneglucuronide has been recommended as the best serum biochemical marker of acne inhyperandrogenic women (237). There are several factors at play in the development of acne in women, but primary amongthese is increased local androgen levels that lead to excessive production of sebum. DHT ismetabolized to 3α-androstanediol glucuronide within the hair follicle withsubsequent release into the circulation, suggesting that this metabolite is a good marker ofperipheral androgen production in women with idiopathic hirsutism (226). In hirsute women, it is well established that increased type I 5-AR in thehair follicle acts on T to produce high local concentrations of DHT that transforms vellushair (nonpigmented, soft, and short) to terminal hair (pigmented, course, and long) inandrogenic-sensitive areas of the skin (235). This study revealed mean serum DHT concentrations in healthy pre-and postmenopausal women of about 9 ng/dL (0.3 nmol/L) and 3 ng/dL (0.1 nmol/L),respectively. With proper care, they’ll produce healthy hair for the rest of your life. A hair transplant is a significant investment of money, time, and hope. What ingredients should I avoid in hair products after surgery? They enter a resting phase before producing new growth around months 3 to 4. However, larger studies are needed on patients with genetically confirmed diagnoses to confirm the findings of our research. On another note, body mass index was not studied in our patients, so the response to the treatment may have been influenced in overweight or obese patients. These 2 therapeutic approaches represent the mainstay of the treatment of micropenis. Hypogonadism established in early fetal lifeleads to the existence of ambiguous or female genitalia in XY newborns. Clinical presentation of male hypogonadism according to the period of lifewhen it is established. However, conversion to DHT is essential in the endorgan for prostate development and virilization of the external genitalia duringfetal life. Most (40%–60%) circulates bind to sex hormonebinding globulin (SHBG), 33% to albumin, and 1%–4% is unbound. Figure 2C,D illustrates the changes in height SDS relative to BA following androgen treatment.Another limitation is that we should have also studied a group of women treated with tibolone, characterized by both a certain androgenic and estrogenic activity.In the Page et al. (55) study,there was no change in hematocrit after subjects were treated with a DHT gel preparationfor 1 month.Although Androgel and Testim have well-established therapeutic efficacies, comparison studies that exist in the literature might prompt the provider to use one more than the other.It is likely these effects are mediated by a reduction in intraprostatic androgen concentrations because 5α-reductase inhibitors lower both serum and intraprostatic concentrations of DHT considerably (12, 13).After completion of the study an additional subject in the DHT group was determined to have been undergoing treatment for concomitant HIV infection that he had not reported at enrollment.Testosterone therapy should be administered carefully to men with benign prostatic hypertrophy and mild to moderate lower urinary tract symptoms. Way back decades ago, many blamed DHT for prostate enlargement; however, in the recent studies conducted, scientists challenged the assumption. It is more potent than androgen receptors and more receptive to DHT than testosterone. Andractim gel comes in hydroalcoholic gel with 2.5 % Dihydrotestosterone. This medicinal product may pose a risk to the environment, (See section 5.3).Interestingly, we observed the same effects by treating ovariectomized rats with T plus the aromatase inhibitor letrozole, thus blocking its conversion into estradiol.This might be ascribable to the general improvement in all the other sexual domains, including, for example, lubrication.The injection formulation resulted in a significant sexual function improvement.The full meaning of DHT is Dihydrotestosterone. Injectable testosterone esters also result in a high incidence of polycythemia compared with gels due to higher circulating testosterone levels. The favorable pharmacokinetic profile and treatment outcomes combined with enhanced tolerability and superior compliance suggests that testosterone gel formulations are a safe and effective treatment in men with hypogonadism. Baseline assessment of prostate cancer risk is necessary in middle-aged and older men before instituting therapy. The predominant indication for gel substitution was either lack of improvement in symptoms or failure to achieve adequate serum levels. In men receiving transdermal gel, testosterone level should be measured after patient has been on treatment for one to two weeks, ideally between two and six hours after gel application. Moreover, a case control study of mentreated with finasteride for BPH found no increased risk of hip fracture (174). Fewerlong-term, placebo-controlled studies have examined the impact of 5AR-Is outside of thecontext of T replacement in men on these anabolic end points, but in a 12-month trial inhealthy young men, neither dutasteride nor finasteride (that significantly lowered serumDHT) altered body composition nor BMD (131,132). Dutasteride in combination with T also did not impact thedose-response effects of T on BMD, body composition, and leg strength (130). Similar results were reported more recently in a 1-year study thatused higher doses of TE alone or in combination with finasteride (131). From these studies, we conclude thatsupraphysiological levels of DHT in men have a modest effect on body composition todecrease fat mass and increase lean mass. Now I am still small and feel that my hormone levels are lower. Dihydrotestosterone (Andractim?) 2.5% gel for topical application Absorption rate is going to be similar to testosterone gel, or roughly 10%, so youre applying 2.5mgs of pure DHT to your nips every time you use this stuff. In the new research, the leading cause of benign prostate hypertrophy or BPH is the high estrogen levels in the body. It is available as a 2.5% gel under the brand name Andractim, which is imported from abroad. My dht is just out of range on the low side, 29 ng/dl, my T and free T are on the low end of normal. Hey @tab and @robbo, what kind of bad effects did you get from using a DHT cream? That is what bothers me most, and I am looking to use andractim to reverse that. Something like oral immunotherapy. Questions remain about long-term outcomes into adulthood, and efficacy in adults with prior lengthy exposure to high-dose testosterone. No adverse effects of topical DHT were reported or observed throughout the 4 months of treatment. In two thirds of males, this results in micropenis. In contrast, exogenous DHT, by lowering pituitary LH production via negative feedback, increases serum DHT while concomitantly lowering serum T concentrations (15, 16, 28). The administration of exogenous T increases both serum T and DHT concentrations (26, 27). Samples were grouped using unsupervised hierarchical clustering based on the expression of 90 androgen-regulated genes. The heatmap depicts the normalized absolute signal intensity of 25 genes commonly identified as androgen-regulated (lower expression blue, higher expression red-brown).