Scite.Ai is a popular literature review tool that revolutionizes the research process for scholars. While Elicit offers tremendous benefits, researchers should remain vigilant and cross-reference information to ensure a comprehensive literature review. Elicit is a game-changing literature review tool that has gained popularity among researchers worldwide. Semantic Scholar is a cutting-edge literature review tool that researchers rely on for its comprehensive access to academic publications. Discovery of the dual orexin receptor antagonist (7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl5-methyl-2-(2H−1,2,3-triazol-2-yl)phenylmethanone (MK-4305) for the treatment of insomnia. In fact, the circulating level of orexins in blood in healthy individuals is very low Range of 2 to 45 pM, representing 1,000 times less than the IC50 of receptors (58–60). Discovery of the dual orexin receptor antagonist (7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl5-methyl-2-(2H-1,2,3-triazol-2-yl)phenylmethanone (MK-4305) for the treatment of insomnia. Four multicenter, open-label, two-period crossover studies were conducted to compare the pharmacodynamic effects of esomeprazole following intravenous or oral administration on acid suppression in 206 patients with symptoms of GERD with or without erosive esophagitis. A 28-day toxicity study with a 14-day recovery phase was conducted in juvenile rats with esomeprazole magnesium at doses of 70 to 280 mg/kg/day (about 17 to 68 times a daily oral human dose of 40 mg on a body surface area basis). In a crossover study, healthy subjects were administered clopidogrel (300 mg loading dose followed by 75 mg per day as the maintenance dosage for 28 days) alone and with esomeprazole (40 mg orally once daily at the same time as clopidogrel) for 29 days. The incidence of ECL cell hyperplasia in these studies increased with time; however, no case of ECL cell carcinoids, dysplasia, or neoplasia has been found in these patients see Nonclinical Toxicology. In a juvenile rat toxicity study, esomeprazole was administered with both magnesium and strontium salts at oral doses about 34 to 68 times a daily human dose of 40 mg based on body surface area. There are no clinical data on the effects of esomeprazole on the breastfed infant or on milk production. Effects on maternal bone were observed in pregnant and lactating rats in a pre-and postnatal toxicity study when esomeprazole magnesium was administered at oral doses of 14 to 280 mg/kg/day (about 3.4 to 68 times an oral human dose of 40 mg on a body surface area basis). If symptoms do not resolve completely after 4 weeks, an additional 4 weeks of treatment may be considered. The majority of patients are healed within 4 to 8 weeks. For the eradication of Helicobacter pylori infection in individuals with duodenal ulcer disease when used in conjunction with amoxicillin and clarithromycin. The products were beautifully present in the site, the prices were really good however, the check it process could be better. Some reviewers also mentioned discrepancies with discount codes and a lack of detailed information about shipping speed and product specifications.See more Based on reviews, created with AI Companies on Trustpilot aren't allowed to offer incentives or pay to hide reviews. A limited number of review types are currently utilized within the health information domain. Supporting a role for endogenous orexin in neurodegenerative/inflammatory brain pathology, orexin expression was found to be elevated in lesioned CNS areas in murine controlled cortical impact (CCI) and transient common carotid artery occlusion (tCCAO), models of traumatic brain injury and cerebral ischemia, respectively (64, 65). This concept gained even more credence with the discovery of neuropeptides exerting both neuroprotective and immunomodulatory actions, and becoming an emerging group of biological agents with a great potential for the treatment of immune-mediated CNS disorders such as narcolepsy, metabolic disorders, Alzheimer's disease, and multiple sclerosis. Particularly, in the healthy brain, microglia, resident macrophage-type immune cells of the CNS that share many characteristics with macrophages, are vital to preserve neuronal health (i.e., to promote formation and elimination of synapses) by maintaining a friendly CNS microenvironment. In addition to their actions in the CNS, these neuropeptides also play a role in various peripheral organs where they regulate appetite, feeding, gastrointestinal mobility, energy balance, metabolism, blood pressure, neuroendocrine and reproductive functions (36–41, 50) (Figure 1). In parallel to its role as a negative regulator of the α subunit, the dissociated Gβ/γ has the ability to modulate signaling pathway cascades including, among others, the regulation of ion channels, the inhibition or activation of adenylyl cyclase, the inhibition of the phosphinositide-3 kinase (PI3K) or the activation of GPCR kinases (βARK) (9). For patients with severe hepatic impairment (Child-Pugh Class C), administered 80 mg as an intravenous infusion over 30 minutes, followed by a continuous infusion of 4 mg/hour for 71.5 hours see Use In Specific Populations. For patients with mild to moderate hepatic impairment (Child-Pugh Classes A and B, respectively), administered 80 mg as an intravenous infusion over 30 minutes, followed by a continuous infusion of 6 mg/hour for 71.5 hours. For patients with severe hepatic impairment (Child-Pugh Class C), the maximum dosage is 20 mg once daily see Use In Specific Populations. Administer oral acid-suppressive therapy following intravenous therapy for a full course of treatment. Exposure to esomeprazole was increased substantially in patients with severe hepatic impairment (Child-Pugh Class C) but not in patients with mild to moderate hepatic impairment (Child-Pugh Classes A and B) compared to patients with normal liver function see CLINICAL PHARMACOLOGY. And oral esomeprazole has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Increases in death were seen at the high dose, and at all doses of esomeprazole, there were decreases in body weight, body weight gain, femur weight and femur length, and decreases in overall growth see Nonclinical Toxicology. We’ve now been using Calecim products for hair and skin rejuvenation for over three years. Don't forget — join MyTemptalia to add products to your wishlist and keep track of what you own. In your pocket by downloading our app, giving you on-the-go access to our reviews Overall, 19 studies, which in total comprised 5,413 anabolic samples, met the inclusion criteria, and passed the quality appraisal from two WHO world regions that reported findings, the Americas and Europe. The review protocol has been published and registered in INPLASY. We used random-effects models to calculate the overall mean estimates for outcomes. I’ve been taking Eroxil for 2 weeks and I’m really impressed with the impact on my sex life. Great products that turned time back by 30 years.» The Nokomis market study established that the products worked well in a high majority of cases. Whether the rejuvenation goes fast or slowly depends solely on the person’s sexual health and is not the fault of the product. Using anti-aging skincare products with these ingredients will really help to reduce the appearance of lines and wrinkles. The formula is very simple with just a few humectants, including glycerin, xylitylglucoside, and anhydroxylitol. The rest of the formula contains a few of the same ingredients as other best selling Embryolisse products, such as liquid paraffin, beeswax, and shea butter. Replenishing the skin’s lipid barrier with products containing squalane — like Embryolisse Filaderm Emulsion — can help to prevent these problems. While the brand is known for Lait-Crème Concentré, they also offer an entire range of no-nonsense skincare products with simple formulations at affordable prices. We highly recommend PeakErect® to men looking for an optimal all-natural sexual enhancement and health supplement. There are no reported side effects, but users with a seafood allergy should avoid the product. In addition, the boost in prostate health may enhance sexual libido and function. This ensures a healthy sexual libido, and there is also a strong link between zinc and prostate health. And, in line with the increasing demand for battery-powered products, they’ve become all the more bullish in their approach to the production of their cordless models .Because treatment with Exium 20 mg may alleviate symptoms and delay diagnosis, patients on long-term treatment should be kept under regular surveillance.These observations suggested the existence of a putative pathogenic link between higher BMI (Body Mass Index) and alteration of orexin signaling in narcoleptic patients (10).A limited number of review types are currently utilized within the health information domain.It tests and reviews all these products, and then writes about both its methodologies and results.CICG Americas has established a presence in major countries in the Americas, including the United States, Mexico, Peru and Brazil.Labeled Verified, they’re about genuine experiences.Learn more about other kinds of reviews.In addition, other countries from this region (Switzerland, France, Italy, United Kingdom, Czech Republic and Slovakia, Austria, and Belgium) are represented in our list of included studies. I'm editing my review to rhe social media community and the Sherum company in regards to the Easter bunnies 🐰. Second, their product was well-... However, I compared the watch reading against the "One-Touch" product and the "FreeStyle Libre 2" product and found the watch r... Every time I tried to use PayPal I would go through the whole process only... A can testify it’s a truly amazing product. Wife is grateful for Eroxil I’m a wife writing about the incredible results my husband has had using Eroxil. What took you so long for this product? A wonderful and superb product. Over the past 10 years I have not had any sexual urges. You can exercise your right to cancel at any time from the moment you place the order and up to 14 days after taking ownership of the goods. If you spot a review which you think is fake, you’re normally able to report or flag it to the marketplace as inappropriate. Take our quiz to find out if you can tell a real review from a fake. In contrast, someone looking to become a vegetarian is more likely to have purchased and reviewed five vegetarian cookbooks, giving the seller a variety of ratings and feedback. Harada S, Fujita-Hamabe W, Tokuyama S. Effect of orexin-A on post-ischemic glucose intolerance and neuronal damage. Role of orexin A signaling in dietary palmitic acid-activated microglial cells. Orexin-1 receptor expression after global ischemia in mice. She is passionate about getting to the crux of the latest scientific studies and sharing important information in an easy-to-digest way to better inform decision-making.Once you are satisfied that the methodology is sufficiently robust, examine any data in the form of figures, tables, or images.If hypocalcemia is refractory to treatment, consider discontinuing the PPI.LPS interacts with the complex toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD-2).In fact, the circulating level of orexins in blood in healthy individuals is very low Range of 2 to 45 pM, representing 1,000 times less than the IC50 of receptors (58–60).I take nothing else, because I’m pretty healthy and active.Thus, these authors can be recognized as leaders in the field of orexin research.For specifically requested colour reproduction in print, you will receive information regarding the costs from SAGE after receipt of your accepted article.Using SH-SY5Y human neuroblastoma cell line, an in vitro cellular model of dopaminergic neurons in Parkinson's disease, other investigators have shown that OXA elicited neuroprotective actions (i.e., anti-apoptotic and antioxidant effects which are mediated by the PKC and PI3K signaling pathways) against MPP(+) and 6-OHDA-induced neurotoxicity (71–73). You may update, amend, or delete Your information at any time by signing in to Your Account, if you have one, and visiting the account settings section that allows you to manage Your personal information. It means that this information may be transferred to — and maintained on — computers located outside of Your state, province, country or other governmental jurisdiction where the data protection laws may differ than those from Your jurisdiction. Your information, including Personal Data, is processed at the Company's operating offices and in any other places where the parties involved in the processing are located. We will retain and use Your Personal Data to the extent necessary to comply with our legal obligations (for example, if we are required to retain your data to comply with applicable laws), resolve disputes, and enforce our legal agreements and policies. To provide and maintain our Service, including to monitor the usage of our Service. Real-time collaboration features also facilitate seamless teamwork among researchers.While DistillerSR offers numerous advantages, there are a few considerations. Moreover, Scite.Ai’s coverage may be limited in certain subject areas and languages, with a possibility of missing relevant studies, especially in niche fields or non-English publications. As with any data-driven tool, occasional errors or inaccuracies may arise, necessitating researchers to cross-reference and verify results with other reputable sources. It is important to verify the credibility and accuracy of the sources found through the tool, as the database encompasses a wide range of publications. The tool employs advanced algorithms to provide personalized recommendations, ensuring researchers discover the most relevant studies for their field. Eroxil gave us both a better love life. After I stopped taking it for about 3 weeks my sex life went down the drain. Never in my life did I have anything that improved my life as much as Eroxil. Lindsey Drayton is the editor of Trends in Cognitive Sciences, Cell Press’s home for reviews in cognitive psychology and cognitive neuroscience. This webinar will cover how to both conceptualize and write a review, how to distinguish your review by making a strong statement, and why writing a review is worth your time. Matt Pavlovich and Lindsey Drayton, editors in the Trends reviews journals group with Cell Press, will give their editorial perspective on what they’re looking for in a review. From 2003 to 2022, 80 countries or regions contributed to research publications on orexin. According to the WoSCC database, the 5486 papers received a total of 207,699 citations, with an average of 37.76 citations per paper (Fig. 3). To provide comprehensive and objective results, various characteristics of the included publications were analyzed both qualitatively and quantitatively in our study. Our data were entirely sourced from the database; therefore, approval from the Ethics Committee was not required. To avoid bias resulting from frequent updates to the WoSCC database, data were retrieved and downloaded on the same day (June 1, 2023). Following reconstitution and administration, discard any unused portion of esomeprazole solution see DOSAGE AND ADMINISTRATION. Is supplied in a single-dose vial as a as a white to off-white lyophilized powder for reconstitution containing 40 mg of esomeprazole. 40 mg of esomeprazole as a white to off-white lyophilized powder in a single-dose vial for reconstitution. Solution at room temperature up to 30°C (86°F) and administer within the designated time period as listed in Table 2 below. Oral antacids may be used during treatment with NEXIUM I.V. Using advanced algorithms and machine learning, Consensus delivers personalized recommendations, saving researchers time and effort in their literature search. With its user-friendly interface and advanced features, it offers a vast database of academic publications across various disciplines, providing access to relevant and up-to-date literature. Researchers should also supplement Consensus with manual searches to ensure comprehensive coverage of the literature.Overall, Consensus is a valuable resource for researchers seeking to optimize their literature review process. By streamlining the literature review process, Consensus allows researchers to extract valuable insights and accelerate their research progress.However, there are a few factors to watch out for when using Consensus. Moreover, SB blocks GABAergic neurotransmission within the medial CeA, indicating that GABAergic neurotransmission is involved in the orexin-mediated regulation of cocaine intake (Schmeichel et al., 2017). Co-injection of SB with OA cannot block cocaine seeking, whereas another OX2R antagonist, TCSOX229, fully prevents the cocaine seeking induced by OA, indicating that the priming effects of OA injection into the pPVT are mediated by OX2R (Matzeu et al., 2016). Therefore, receptor antagonists may be key neurobiological substrates necessary for maintenance of nicotine addiction in human smokers. Taken together, these data indicate that nicotine-enhanced OA/OX1R transmission plays an important role in regulating the stimulatory properties of nicotine. Pretreatment with the OX1R antagonist SB334867, but not the OX2R antagonist TCSOX229, decreases reinstatement of nicotine seeking. In general, the results showed that 5-Fluorouracil derivatives had a significant effect (in vitro and in silico study) compared with 5-Fluorouracil The cytotoxicity test showed that the best IC50 was 3-NO2-benzoyloxymethyl-5-Fu among other 5-Fu derivatives with 348,398 µM. The First step, in silico study, showed that 5-Fu derivatives had better binding affinity than 5-Fu. The plasma elimination half-life of esomeprazole following intravenous administration of NEXIUM I.V. The major part of esomeprazole’s metabolism is dependent upon the CYP2C19 isoenzyme, which forms the hydroxy and desmethyl metabolites. The apparent volume of distribution at steady state in healthy subjects is approximately 16 L. Input and output of orexin neurons at interface of sleep, stress, reward, and… Loss of orexin signaling could cause cataplexy by reducing activity in motor excitatory… This figure summarizes predicted orexinergic… Schematic drawing showing main projections of orexin neurons. Intravenous therapy is aimed solely at the acute initial management of bleeding gastric or duodenal ulcers and does not constitute full treatment. The recommended dosage for pediatric patients is based on age and body weight as shown in Table 1 below. The stability of esomeprazole sodium in aqueous solution is strongly pH dependent. Our Nexium Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Some reports have revealed that orexins were also able to activate the cAMP, PI3K/Akt, JNK and MAPK/Erk1/2 signaling pathways (Figure 2). Despite the major role of orexins in CNS, these two neuropeptides were also studied, to a lesser extent, in the peripheral nervous system (PNS). Moreover, the central action of orexins regulates food intake, energy homeostasis, reward seeking, stress, motivation and drug addictions10,11 (Figure 1) which included the addiction to cocaine, opioids, amphetamines, cannabis, alcohol and nicotine. The role of the orexins/OXR system was firstly widely studied in the central nervous system (CNS) (Figure 1). Social proof is evidence that other people have purchased and seen value in your product, which can be especially important in the ecommerce space. When analyzed effectively, they can also influence brand reputation, guide product development, and strengthen long-term customer relationships. In case you’re new to customer review sites or you’re unsure of where to find them, I’ll take you through the basics first and explain why they’re so important for your business. Additional hand searches were conducted to obtain studies not found in the primary literature search. We reviewed literature that assessed the quality and quantity of AAS found on the black market. Join us as we share the science, insights, and solutions that explore what it will take to make this ambition a reality — together with research and healthcare communities. International Journal Of Electrochemical Science See the latest stories and advice and find out about industry developments, policies and initiatives of interest to our reviewers. Let us guide you through each stage and offer you a selection of resources, tips and tricks to make your reviewing experience as positive as it can be. Find out why reviewers perform this vital role, how they are recognized and how you can volunteer to review yourself. Over the next nearly ten years, orexin receptor antagonists have remained popular, showing no signs of decline. In 2014, suvorexant became the first dual orexin receptor antagonist approved by the FDA. As shown in Figure 8, research on orexin receptor antagonists emerged as a hotspot in 2013. The critical thinking and assessment required for peer-review are outside the scope of generative AI and AI-assisted technologies, and there is a risk that the technology will generate incorrect, incomplete or biased conclusions. Since peer review is confidential, you also must not share information about the review with anyone without permission from the editors and authors. If you do decline the invitation, it would be helpful if you could provide suggestions for alternative reviewers. Respond to the invitation as soon as you can (even if it is to decline) — a delay in your decision slows down the review process and means more waiting for the author. Furthermore, in order to provide updates and feedback to reviewers, most Elsevier journals inform reviewers about the editor’s decision and their peers’ recommendations. Both myself and my wife are completely satisfied with the performance brought into our sex life.If the presence of orexins in CNS, PNS and ENS was well established, the circulating level of these neuropeptides in healthy human blood was very low (about 2 to 50 pM) which is not enough to activate orexin receptors18,19.The journal publishes both reviews, which help researchers understand the state of science on important chemistry topics, and letters, which concisely communicate the most interesting results.Eroxil not only helped me to have good and long lasting erections, it increased blood circulation to my legs.The quantitative data was expressed as standardized mean difference (SMD), and numeration data was presented as relative risk (RR).It has also been shown that OxA contributes to changes of the white fat morphology via stimulation of preadipocytes proliferation and inhibition of apoptosis but OxA has no effect on lipolysis in fat tissue derived from human explants. For qualitative research make sure that a systematic data analysis is presented and sufficient descriptive elements with relevant quotes from interviews are listed in addition to the author’s narrative. If the manuscript you are reviewing is reporting an experiment, check the methods section first. If the journal in question does not require you to respond to a list of specific questions, you might find it useful to consider these questions and the below generic points when you are preparing your review report. CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice. Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2. Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns. Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A. All manuscripts are reviewed initially by the Editors and only those papers that meet the scientific and editorial standards of the journal, and fit within the aims and scope of the journal, will be sent for outside review. It adheres to a blinded peer-review process in which the reviewer's name is routinely withheld from the author unless the reviewer requests a preference for their identity to be revealed. Manuscripts are generally restricted to a maximum of 9,000 words (excluding references and including primary text, notes, tables, and figures), while commentaries should be no longer than 1,000 words. Research in the Americas was only done in Brazil, which alone includes 7 of the 19 studies. The geographic scope of the included studies is limited to two world regions, where 37% and 63% respectively were conducted, and these studies reported findings from the Americas (AMR) and Europe (EUR). The peer-reviewed literature of qualitative and quantitative analyses of AAS has considerably increased in the last few years. All study characteristics can be viewed in detail in Table 4. After the quality appraisal stage, an overall number of 19 full-text articles were included for data extraction and analysis. The mRNA sequences of human orexin contain 616 bases, encoding a precursor peptide (prepro-orexin) that contains 131 aa residues.Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.Your source of information, guidance and support for reviewing with Elsevier.This includes the production of blowers, pruners, trimmers, and multi-attachment tools through 2025.It’s estimated that over 70% of all the costs involved in eDiscovery are generated by the review process alone.When you sit down to write the review, again make sure you familiarize yourself with any journal-specific guidelines (these will be noted in the journal’s guide for authors).These findings provide detailed mechanistic insight into the atmospheric reactivity of 3HB and may be extended to other structurally related VOCs, contributing to a better understanding of atmospheric oxidation processes. In addition, OA/receptor signaling in DR serotonergic neurons that express both OX1R and OX2R plays a pivotal role in the prevention of cataplexy-like episodes (Hasegawa et al., 2014). Moreover, two efferent pathways of orexin-containing neurons are likely to be mediated by DR serotonergic and LC noradrenergic neurons. Conversely, monoaminergic neurons may decrease the inhibitory effect on orexin neurons, thereby stabilizing wakefulness through this dynamic mechanism. Wonderful articles for service men and women! But others, even with appropriate diet and lifestyle habits for GERD, cannot significantly reverse the reflux they have.” “Some patients with dietary adjustments can reverse the triggers leading to GERD,” Khan says. Generally, GERD-related heartburn may occur two or more times a week, or it may happen once or twice a month but recur for several years, Khan explains. “Symptoms more than two times a week and where there is concern for inflammation in the esophagus is considered moderate or severe GERD.” “Usually, if the heartburn is mild and less than two times a week, it is considered mild GERD,” says Saleem Chowdhry, MD, a gastroenterologist with University Hospitals in Westlake, Ohio. Surprisingly, we did not identify any studies from the US, Middle East, Oceania, Asia, or Africa.We also ask reviewers to declare any potential conflicts and read the guidelines for reviewers .At ePharma, we’re committed to providing accurate and accessible health information.These results show that the orexin/receptor system can activate potent intracellular signaling via pathways other than the classical signaling pathways (Figure 3).When it comes to making your product stand out, reviews with the most shiny gold stars are the ones that customers are looking for.Explore data-driven findings shaping the industry.The efficacy of esomeprazole in patients with GERD symptoms control, include heartburn, acid regurgitation, dysphagia, and epigastric pain, remains controversial compared with other acid suppression drugs (27–32). Customer reviews will inevitably include negative, constructive, or even neutral feedback from your consumers. Showing potential customers that a business has many satisfied customers through testimonials and user reviews helps build trust that a business is legitimate and trustworthy.” When your company shares customer reviews with consumers, you’re offering social proof to shoppers. There are three major reasons why customer reviews are important to your business. By the end I was gleefully indulging in chaotic levels of carnage that reminded me more of a CoD campaign than a slow-paced horror game.That’s a big change from the considerably more vulnerable version of Ethan from Resident Evil 7 – particularly in its first half – and a throwaway reference to military training in the prologue is used to explain why he feels substantially more combat ready this time around. Still, what Village’s variety of grunts may lack in smarts they certainly make up for in sheer numbers, and although I rarely encountered clusters of more than a handful enemies at a time for the first few hours (outside of the initial overwhelming village reception), at somewhere around its midpoint the size of these enemy swarms started to swell substantially. Village remedies this by throwing a significantly broader set of nasties into your crosshairs; in fact, the last time there was a line-up of village people this diverse they were singing disco songs about the YMCA. Check with your physician for additional information about side effects. This document does not contain all possible side effects and others may occur. McVary K, El-Arabi A, Roehrborn C. Preservation of sexual function 5-years after water vapor thermal therapy for benign prostatic hyperplasia. Regardless, that's additional health policy questions which really need to be addressed. We're doing these procedures and there is an expense to our society and our health care system. Eroxil’s by far the best I’ve used I feel great sexual excitement again. Other natural products were pure bunk. Years of disappointing sex life ended Years of disappointing sex life has now been returned to my late teens. Subsequent pharmacokinetic analyses predicted the following dosage regimens would achieve comparable steady-state plasma exposures (AUC0-24) to those observed in adult patients administered 20 mg of NEXIUM I.V. Esomeprazole plasma AUC values were 183% and 60% higher in pediatric patients aged 6 to 11 years and 12 to 17 years, respectively, compared to adults. The AUC and Cmax values of esomeprazole were slightly higher (25% and 18%, respectively) in the elderly as compared to younger subjects at steady state. The plasma clearance (CL) is approximately 5.9 to 7.2 L/h during administration of NEXIUM I.V. The present review suggests that orexins or the orexin neural circuitry represent potential therapeutic targets for the treatment of multiple pathologies related to inflammation including intestinal bowel disease, multiple sclerosis and septic shock, obesity and digestive cancers. These past 20 years had revealed that orexins/receptors system was also present in the peripheral nervous system where they participated to the regulation of multiple functions including blood pressure regulation, intestinal motility, hormone secretion, lipolyze and reproduction functions. The present review gathers recent data demonstrating that orexins may have a therapeutic potential in several pathologies with an immune component including multiple sclerosis, Alzheimer's disease, narcolepsy, obesity, intestinal bowel diseases, septic shock, and cancers. To my surprise I’ve experienced a general sense of well-being and greater sexual satisfaction. Felt like a young man again After taking Eroxil for a few days my erections lasted longer and were much harder. Eroxil seems to have worked wonders within several days. This caused my sex drive to diminish greatly. The orexins, also known as hypocretins, are a pair of neuropeptides that are mainly derived from orexin-containing neurons in the lateral hypothalamus (LH). Furthermore several reports showed that orexin/receptor pathways are involved in pathological processes of neurological diseases such as narcolepsy, depression, ischemic stroke, drug addiction and Alzheimer’s disease (AD). This review provides an overview of the orexin history, the mechanism of action, the relation to insomnia, and key features of available drugs mediating orexin signalling. Instead, they temporarily block the orexin pathway, causing a different pattern of effects, e.g., less morning or next-day effects, motor dyscoordination, and cognitive impairment. Abstract This review article examines the synthesis of silver nanoparticles (AgNPs), highlighting modern methods in their production. Key dynamical and structural properties were analyzed, including ionic current profiles, potential of mean force, ion retention times within the nanotube, radial distribution functions, and the ratio of water molecules transported relative to ions. Furthermore, in vitro studies have been initiated to assess the anti-proliferative activities against various cancer cell lines.This research offers valuable insights into the design and development of novel EGFR inhibitors. The journal publishes both reviews, which help researchers understand the state of science on important chemistry topics, and letters, which concisely communicate the most interesting results. For further information including guidance on fair dealing for criticism and review, please see the Copyright and Permissions page on the SAGE Author Gateway. Date published: 01 July 2022 High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss. Expression and potential role of the peptide orexin-A in prostate cancer. Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease. Bank Information Production Over the Business Cycle Coupling between orexin/receptor and Adenylyl cyclases (AC)/cAMP has been reported in several studies. The existence of two orexins and two receptors subtypes is bound to create diversity within cellular signaling pathways. Together, these discussions summarize our current knowledge of the orexin/receptor system and the prospects for applying this information to the clinical treatment of neurological diseases. Orexins orchestrate their effects by binding and activating two G-protein–coupled receptors (GPCRs), orexin receptor type 1 (OX1R) and type 2 (OX2R). Orexin receptor antagonists seem to be devoid of any dependence and tolerance-inducing effects, rendering them a viable option for longer-term treatment. Orexins and their receptors (orexin/hypocretin receptors 1 and 2) are crucially involved in the regulation of sleep and wakefulness.16,17 Notably, orexin agonists and antagonists have been shown to effectively treat disorders such as excessive somnolence and insomnia. Yves Dauvilliers is the leading author in orexin research with 69 published studies, followed by Abbas Haghparast and Takeshi Sakurai. The productivity and development of a specific area can often be gauged by the volume of publications it generates, suggesting that orexin research continues to be a focal point for scholarly exploration. Over the last 20 years, from 2003 to 2022, our findings indicate that the number of publications on orexins has remained consistently substantial, underscoring the enduring significance of this research field. Finally, the keywords were divided into 19 different clusters to identify research hotspots in orexin studies (Fig. 9). An outstanding product. Able to get a good erection and it stays erect for a long time. This is why I bought your Eroxil and within 2 weeks I can achieve a good erections again and ejaculate. Eroxil simply “took over”. As an added bonus, the product pages rank high in Google, so getting a few positive user reviews on their site could be beneficial for your brand recognition. So if you’re in the beauty business, consider directing your shoppers to review your products on Influenster to help attract new customers, too. If you sell consumer products, Influenster is a review site you’ll want to make sure you’ve considered. This is why I think driving Yelp reviews is likely worth your time, especially if you rely on local foot traffic for your business (such as restaurants, bars, brick-and-mortar retail, etc.). Unlike prescription drugs the effects are more natural and with none of the side effects. After 4 weeks taking Eroxil found a great difference. I’m so glad I bought the box. I’m very satisfied with Eroxil. This means you must not share them or information about the review with anyone without prior authorization from the editor. Once you have delivered your review, you might want to make use of Elsevier’s Reviewer Hub to ensure that you receive credit for your work. The submission system provides reviewers with a notification of the final decision, if the journal has opted in to this functionality. This literature analysis, based on visualization, can guide scholars in quickly understanding the research focus and development trends of orexin in neuroscience. Therefore, it is essential to further investigate the dysregulation of the orexinergic system in neurodegenerative diseases and its role in their pathogenesis. However, the exact roles of the orexinergic system in these diseases and the underlying mechanisms are still not fully understood. So I am curious to know if there have been any further studies on this effect of co-Q-10. I did suspend the dosage for several weeks two or three times, to see if it made a difference. I have continued the same dosage since that time, and I have not had a single cold while taking it. This is more a question for the experts than a review. I take nothing else, because I’m pretty healthy and active. This was characterized by increased expression of the M2 microglial marker arginase-1, while inhibiting the production of pro-inflammatory TNFα, IL-6 and inducible nitric oxide synthase (iNOS) mediators (66). Moreover, wakefulness is inhibited only by OX2R and dual orexin receptor antagonists, but not by selective OX1R antagonists (99). Studies using orexin receptor transgenic mice have suggested a major role for OX2R in narcolepsy. Functional OX1R was always expressed in HT-29 cells resistant to 5-FU treatment in which OxA induced mitochondrial apoptosis (68). This expression was recovered in 10 colon cancer cell lines including HT-29, LoVo, Caco-2 (68). The first main line of treatment was surgery. OX1R was also expressed in human non-digestive cancers including prostate cancer (69), neuroblastoma (67), cortical adenomas (70), pheochromocytomas (71) and in endometrial carcinoma (72). There's a health policy issue here. Another area is utilities, quality of life. It's something which we think we have insight into, but we really don't have good data. With its advanced search capabilities, researchers can quickly find relevant studies from multiple databases, saving time and effort. It will also dispel some common myths about review articles—including that reviews must always originate from an editor’s invitation—and give advice for how to propose a review to an editor. People who write reviews have ownership to edit or delete them at any time, and they’ll be displayed as long as an account is active. According to studies on drug interactions, esomeprazole does not interact clinically with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin. In addition, studies indicate the testosterone-boosting benefits of PeakErect® and its ability to enhance sexual libido, build muscle mass and strength, improve fertility, and support prostate health. The manuscript submission and peer review procedure is unchanged. Please note that the Editors are not obliged to invite any recommended/opposed reviewers to assess your manuscript. Initial submitted figures should be of high enough quality to be read on-screen or in printouts by reviewers. If you cite your works, list them as "citation deleted for blind review" in the text and omit them from the reference list. The author is responsible for compliance with the most recent published APA format (6th ed.) and for the accuracy of all information, including citations and verification all references with citations in the text. These results suggested that orexin levels have a significant correlation to the time of day. However, pharmacological therapy has potential negative effects, such as daytime drowsiness, tolerance, dependance and withdrawal symptoms (Dundar et al., 2004; Lieberman, 2007), thus new insomnia therapy with less negative effects is under investigation. These results show that the orexin/receptor system probably promotes wakefulness and inhibits sleep by regulating complex circuits. Using orexin-knockout mice as a model of human narcolepsy, DA was shown to suppress cataplexy mediated by D2-like receptors and sleep attacks modulated by a D1-like receptor, confirming that dopaminergic mechanisms contribute to narcolepsy symptoms (Burgess et al., 2010). Sherum sells subpar products that ship… The study using preclinical mouse models xenografted with AsPC-1 cells or cells isolated from patient’s tumor indicated that OxA reduced the tumor development by induction of apoptosis. OxA induced SHP2-dependent apoptosis in AsPC-1 cells derived from human PDAC as well as in PDAC slices from tumor patients maintained in culture. Global studies indicated that more than 90% of patient cancer mortality was related to chemoresistance. Although, preproorexin and OxA were immuno-detectable in total colon, no detection of preproorexin was obtained in normal and dysplastic epithelium suggesting that endogenous OxA has no impact on tumoral growth. Orexin/Receptor Signaling and Ischemic Stroke It allows these innovative products to copy exactly the natural molecules produced by the human body. In pregnant patients accidentally exposed to hydroxyurea, the risk should be discussed with the patient to determine whether to continue the pregnancy. However, animal studies have reported malformations; therefore, the use of hydroxyurea during pregnancy is not recommended. Reviewers are authenticated through LinkedIn to ensure they’re actual users, though reviews can still be posted anonymously. G2 is niche in that it’s built specifically for software and services products. I’ve also used it to review software when I was looking to purchase an NPS survey tool for my company, and found it extremely helpful in finding reviews for my specific buying criteria. I’m a huge fan of G2, having used it both as a software reviewer and as a CSM trying to drive reviews from my customers. No teratogenic effects have been identified in animal investigations. Esomeprazole magnesium 40 mg once daily is administered for 7 days in combination with clarithromycin 500 mg twice daily and amoxicillin 1000 mg twice daily. In healthy volunteers, the apparent volume of distribution at steady state is roughly 16 L. It is recommended to take esomeprazole at least an hour before meals. When compared to fasting settings, the AUC following a single dosage of esomeprazole is reduced by 33-53% after eating. In that case, Google’s famous search abilities didn’t seem to transfer to its document review process. During the document review, Samsung’s outside counsel improperly redacted a sensitive Apple contract it had obtained during the discovery process, a contract that was under a protective order, limiting its use to the litigation alone. But the case also showed that even the biggest companies can stumble in the face of eDiscovery review. A more recent case demonstrates the danger inherent in the review process. Co-administration of esomeprazole with oral contraceptives, diazepam, phenytoin, quinidine, naproxen (non-selective NSAID) did not seem to change the pharmacokinetic profile of esomeprazole. Concomitant administration of esomeprazole and either naproxen (non-selective NSAID) did not identify any clinically relevant changes in the pharmacokinetic profiles of these NSAIDs. Concomitant administration of omeprazole 20 mg once daily and digoxin in healthy subjects increased the bioavailability of digoxin by 10% (30% in two subjects) see DRUG INTERACTIONS. Omeprazole, given in doses of 40 mg daily for one week to 20 healthy subjects in cross-over study, increased Cmax and AUC of cilostazol by 18% and 26% respectively. These nodes exhibit the most pronounced citation bursts and signify emerging trends in orexin research. The keyword with the highest frequency was “neurons” (981), followed by “sleep,” “food intake,” “receptors,” and “neuropathology.” The majority of nodes are represented by dark green circles, indicating their significance through strong betweenness centrality. The co-occurring keywords shown in Figure 7 highlight the prominent topics within the field of orexin research. I’ve been taking Eroxil for 2 weeks and I’m really impressed with the impact on my sex life.Regained energy, improved strength and spontaneous sex!Considering that chronic inflammation encompassing IBD, pancreatitis, hepatic fibrosis and metabolic syndrome constitute a high-risk factor to develop cancers (131), the role of orexins in inflammation represents a major question.In order to QC your work, include a second level review of all designated production documents (or a sample of them) by senior attorneys and randomly review the team’s coding to check for inconsistencies.This pro-survival ability of orexins is related to a reduction in caspase-3 activity (Sokoowska et al., 2012).Nokomis products are completely different from other natural products in this field. Drug Development of 5-fluorouracil is an effort to obtain higher activity and a specific target receptor compared with 5-fluorouracil as a first-line drug for breast cancer. Abstract 5-Fluorouracil (5-Fu) is an antimetabolite class of anticancer agents that induces apoptosis by inhibiting thymidylate acid biosynthesis. Overall, the study concludes that lithium-decorated TAS is a promising candidate for effectively detecting HCN gas. The calculated negative adsorption energies and thermodynamic data suggested that HCN adsorption on Li@TAS is thermodynamically favorable, exothermic, and spontaneous under experimental conditions. Based on the acquired experimental data, the optimal conditions for the nucleophilic addition–coupling pathway were established, and the plausible reaction mechanisms were proposed. By employing advanced algorithms and natural language processing, it efficiently analyzes and summarizes academic papers, saving researchers valuable time. It is advisable to cross-reference its findings with other sources to ensure a comprehensive review. By leveraging advanced algorithms and machine learning, Lateral saves researchers precious time by retrieving relevant articles and uncovering new connections between them, fostering interdisciplinary exploration.While Lateral provides numerous benefits, users should exercise caution. Additionally, occasional inaccuracies in metadata have been reported, making it essential for users to cross-reference information with reliable sources. However, researchers should be cautious of potential biases in the recommendation system and supplement their search with manual verification to ensure a comprehensive review. In a preclinical model, where cancer cells lines derived from colon, pancreas, liver and prostate cancers were sub-cutaneously xenografted, OXA treatment induced a strong reduction of tumor volume (22). Orexins treatment of digestive cancer cell lines derived from colon, pancreas and liver cancers (22, 139, 143) induced a strong cell death by apoptosis. In 2011, our group had demonstrated that OX1R but not OX2R was highly expressed in colon cancer cell lines and colorectal tumors from patients (139). She is excited about our new love life we thought we lost for good. Our love life is like 15 years ago. Eroxil gave back that old tingle and renewed the romance with my wife of 41 years marriage. Eroxil helped man with K.S. Eroxil helped me to function again. You’re free to respond to reviewers, too, but I recommend taking a balanced and polite approach to any negative reviews you receive, as Yelpers are in a pretty tight-knit community. As the largest travel site in the world, it has over 225 million reviews, opinions, and photos taken by travelers. If you’re in the travel, hotel, airline, entertainment, or restaurant industries, you’ll want to check out the reviews on the popular website, TripAdvisor. Each company’s page provides a list of all its reviews, which includes consumers’ star ratings as well as a short explanation for its score. A nonprofit organization, Consumer Reports is an independent product-testing organization that runs unbiased tests to rate and recommend products. Eroxil is the best product available Thank you for this new wonderful product. I alerted the pharmacist about Eroxil and now we carry it all the time. After taking Eroxil for 2-1/2 weeks sexual potency returned as well as great orgasms and semen flow. Eroxil gave back sexual urges I’m 82. Tried other natural products with no results.» You are encouraged to report negative side effects of prescription drugs to the FDA. Following endoscopic hemostasis, patients were randomized to either placebo or NEXIUM I.V. In these studies, after 10 days of once daily administration, NEXIUM I.V. 20 mg and 40 mg was administered as a 3-minute injection in two of the studies and as a 15-minute infusion in the other two studies. Or oral esomeprazole once daily for 10 days (Period 1), and then were switched in Period 2 to the other formulation for 10 days, matching their respective dose from Period 1. Yes, reviews are a proven ranking signal for Google and AI-driven platforms. Do reviews affect visibility in traditional or AI search? Online reviews are a core ranking factor for traditional and AI search platforms. How do online reviews impact local search rankings? It matters because reviews directly impact customer trust, purchase decisions, local SEO rankings, and visibility in AI search platforms. What is peer review? Now I can function anytime. Thank you Bell Lifestyle for changing my life. Eroxil helped to make them last long enough to please my partner. The presence of an ectopic expression of OX1R in intestinal bowel disease (IBD) including Crohn’s disease and ulcerative colitis, in pancreatitis and digestive cancers as colon, pancreas and liver cancers, has been demonstrated. Recently, the structure of OX2R complexed with OxB has been reported, suggesting that the molecular mechanisms which govern the activation or inactivation of receptors were located in the OX2R orthosteric site. However, the majority of these studies seemed to show that OxA directly or indirectly via the inhibition of glucagon release, regulated the insulin secretion. Patients with diabetes. If you see evidence of this, be especially wary, as it's possible the seller is deliberately manipulating the product listing to make it seem more appealing to buyers. Often, the reviewer will promise to change or update their review after they’ve tried it, but almost never will. Read on for our top tips on spotting a fake review. In the case of Celestron, they use their propietary SkyAlign software that allows you to select objects from a database and the telescope automatically aligns itself to track the object(s) you want. Drive type However, the absence of orexins secretion in this model, led to cataplectic attack symptoms. This model has revealed that the regulation of feeding and appetite were not the major physiologic role of orexins. To elucidate the role of orexins in feeding, the Yanagisawa’s group has developed a knock out mice invalidated for the hypocretin gene. From this discovery, the two orphans GPCRs have been identified as hypocretin (Hcrt)/orexin receptor 1 (OX1R) and Hcrt/orexin receptor 2 (OX2R) which belong to the large class A rhodopsin-like subfamily of GPCRs. Structure-activity analysis of truncated orexin-a analogues at the orexin-1 receptor. Smart D, Jerman J. The physiology and pharmacology of the orexins. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. In less than 25 years, the orexins/OXR system has been discovered and its major pathophysiological roles in CNS have been identified. Furthermore, its subsequent oxidative homolytic dimerization and Sonogashira-type C–C cross-coupling reaction with benzyl chloride were explored. The data indicate that higher concentrations enhance antibacterial and antifungal action, and the Pt-complex exhibits more synergistic effectiveness and demonstrates excellent antibacterial properties against Streptococcus pyogenes. The antioxidant activity indicates that the Ru (III) complex exhibited superior antioxidant efficacy compared to the others. All structures of these novel compounds were described using spectroscopic approaches, including 1H,13C-NMR, UV-Vis, mass spectrometry, FTIR, metal, and elemental analysis, in addition to magnetic susceptibility and conductivity measurements. Chromatographic and spectrophotometric analyses identified a diverse profile of phenolic compounds and vitamins, including ascorbic acid and α-tocopherol. In parallel, orexin receptors are also expressed in peripheral tissues including the gastrointestinal tract, adrenal gland, endocrine pancreas, reproductive system, and adipose tissues (50, 57). Orexins stimulated Akt kinase activation in rat cortical neurons subjected to hypoxic stress, and the pro-survival action of orexins displayed in a concentration- and time-dependent manner (Sokoowska et al., 2014). The selectivity of orexins for OXRs and the distinct distributions of the receptors may be responsible for the differential physiological effects of the orexin/receptor pathway. In this review article, we focus on the expression levels and physiological functions of orexins and their receptors. When it comes to choosing which customer review site to prioritize for this effort, you’ll want to first consider which sites your potential customers are using (or most likely to use). Using X posts (I still want to call it a tweet!) that feature a user handle and a photo in your marketing content makes that review feel even more personal, which helps your audience relate to it more. All they have to do is go to the Reviews section of your Page, click yes or no under the “Would you recommend” banner, write their review, and then decide if they’d like to make their review public. Anyone logged into Facebook can post a rating or review of a business. Facebook’s review structure is a recommendation rate (versus a standard rating scale), and asks reviewers if they’d recommend the business. Cox CD, Breslin MJ, Whitman DB, Schreier JD, McGaughey GB, Bogusky MJ, et al. Promotion of sleep by targeting the orexin system in rats, dogs and humans. Roecker AJ, Cox CD, Coleman PJ. Indeed, most of those receptors are potential targets in colitis such as chemokine receptors (135), cannabinoid receptors (136), histamine receptors (137), and neuropeptide receptors (138). In this context, the identification of new targets represents a major goal in the treatment of this pathology. Currently, the treatment of UC is dependent on the severity of disease. The major symptoms are abdominal pain, persistent diarrhea including bloody stools, weight loss, and large fatigue (130). UC is a crippling disease characterized by relapsing-remitting cycles affecting exclusively the mucosa of the colon and rectum following a distal to proximal inflammatory gradient (130). Lin et al. (1999) first cloned the mutant OX2R gene in a canine narcolepsy model and showed that disruption of OX2R caused canine narcolepsy, suggesting a therapeutic target for the treatment of narcoleptic patients. The important role of the orexin/receptor system in both of the above strongly suggests that it is involved in the pathogenesis of narcolepsy. Indeed, accumulating evidence shows that the orexin/receptor system is ectopically expressed in several neurological disorders, suggesting that it plays an important role in the incidence and pathogenesis of these diseases. The extensive projection of orexin innervation and the characteristic expression of receptors appear to provide the structural basis by which the orexin/receptor system participates in regulation of multifaceted functions. Some articles also included other classes of substances in their analysis, such as WADA classes S2, S3, S4, S5, dietary supplements, stimulants, and sexual performance enhancers. In addition, other countries from this region (Switzerland, France, Italy, United Kingdom, Czech Republic and Slovakia, Austria, and Belgium) are represented in our list of included studies. The country with the highest number of included studies in this region is Germany with a total of three studies. In the case of Europe, the studies are divided among several countries.