Side Effects of Testosterone Boosters

As men age, their testosterone levels naturally decline, leading to symptoms such as fatigue, reduced muscle strength, weight gain, and lower sex drive. When testosterone reaches supra-therapeutic levels, aggressive behavior and increased rates of suicide among adolescent users have been reported; however, no study has documented a negative impact on cognition in men patients receiving TRT. In a large meta-analysis of 18 prospective studies that included over 3500 men, there was no association between serum androgen levels and the risk of prostate cancer development. What’s more, the research found that many supplement stores are more than happy to sell boosters to teenagers . The AAP (American Academy of Pediatrics) doesn’t recommend T boosters in either young or late teens. Drawn by the allure of effortless muscle gain and enhanced athletic prowess, many are unaware of the potential pitfalls. Look for supplements tested for purity and potency, and avoid products with harmful additives or unverified claims. Unlike anabolic steroids, these supplements do not introduce external testosterone into the system; instead, they aim to stimulate the body's own production through nutritional and botanical support. Common use cases include improving physical performance, enhancing muscle mass gains, increasing energy levels, supporting sexual health, and counteracting age-related hormonal decline. These foods help increase their performance, recover muscles, tackle exhaustion, and improve overall health. You can use supplements for this purpose as they do not pose any threat or risk to your health.

There are some minor side effects, whereas others result in severe complications if left unchecked in the right way.
The available literature supports a role for TTh in men with low testosterone levels, ED, and low libido, with symptomatic improvement in these men.
According to a review published in the Molecules journal, it’s an effective testosterone supplement, but it produces side effects.
However, there was a higher incidence of pulmonary embolism, acute kidney injury, and atrial fibrillation among men who received testosterone replacement.
These are supplements with very little evidence to support their use.
High SHBG levels can lower free and bioavailable testosterone (explained below).
Some studies suggest that testosterone therapy may actually lower LDL-c but this is something I have not seen clinically in my practice.

Patients suffering from one of these three groups exhibit distinct features in terms of androgen levels, age, and body mass index. There is now evidence that the spectrum of complaints of testosterone deficiency cannot be related to a specific threshold of testosterone concentrations, but that thresholds vary with the various symptoms of testosterone deficiency (2). Furthermore, this information is relevant for the design of clinical trials on testosterone replacement therapy. When you take synthetic testosterone, it can reduce the amount your body makes naturally and will significantly reduce sperm production. Testosterone therapy can nudge your prostate, that little walnut-shaped gland below your bladder, to grow. Early studies hinted this might raise the risk of clots or heart problems, but results were mixed and the first randomized trials were too small to settle it. So when you’re choosing your TRT provider, make sure regular blood tests are included in your treatment plan. These require careful monitoring and regular blood tests to ensure treatment stays safe. Men experiencing low levels of testosterone may have difficulty maintaining erections. So, lower levels of testosterone would lead to decreased libido. Men with low levels of testosterone will also experience lower sex drive. As he ages, the amount of testosterone his body produces starts to fall.

Although there is encouraging evidence for the efficacy of transdermal T therapy (gels and patches), the data are limited 22, 75-77.
Several of thesemanufacturers did not report the exact quantities of active ingredients in their supplements, providing only lists of ingredients.Patients should be counseled regarding the minimal standardization of ingredients and concerns regarding supplement manufacturingprocesses35–38.
Although testosterone therapy remains popular, concerns about side effects may ultimately reduce demand.
When administered intravenously, they bind with androgen receptors, increasing muscle mass and bone mineral density (BMD) while improving energy levels, mood and cognitive functioning.
Contact with excess testosterone can affect children’s genitalia and cause premature pubic hair development and aggressive behavior.
The following lifestyle adjustments can help men undergoing Testosterone therapy get better results and manage their symptoms effectively.

Henceforth, testosterone boosters and steroids are same-same but different. Unfortunately, the contraceptive effects of testosterone are irreversible and have been proven by two WHO studies. Following are some of the studies that hint at the dangerous side effects of testosterone pills. Increased aggression, loss of interest, extreme paranoia, and irritability are some of the behavioral changes witnessed in men after taking testosterone boosters. Several different types of testosterone replacement exist including tablets, injections, transdermal systems, oral, pellets, and buccal preparations of testosterone. While the questionnaires, the Androgen Deficiency in Aging Male (ADAM)35,36 and the Aging Male Symptoms Scale (AMS)37,38 (Table 1), may be sensitive markers of the low testosterone state (97% and 83%, respectively), they are not tightly correlated with low testosterone (specificity 30% and 39%), particularly in the borderline low serum testosterone range. Results were similar for bioavailable testosterone.5–7 In men, endogenous testosterone concentrations are inversely related to mortality due to cardiovascular disease and all causes. The purpose of this review is to discuss what is known and not known regarding the benefits and risks of TRT. Each of the testosterone treatments - pills, gels & creams, injections, and patches - has a specific list of possible side effects according to its particular use. Many doctors are hesitant to prescribe testosterone to women due to its side effects, whose severity is often more pronounced than the symptoms of testosterone imbalance they're prescribed for. "Overpromises on muscle and libido; effects faded fast, total placebo," echoed forum posters, highlighting plateauing after weeks and hormone disruptions like elevated prolactin. ✔ A 2016 study in The Aging Male found only modest libido tweaks but no significant testosterone spike in healthy men. In cross-sectional studies, men with low testosterone (defined by the US Food and Drug Administration as levels less than 300 ng/dL) have a greater prevalence of ED when compared to men with normal testosterone levels 13–15. Numerous studies have examined the relationship between testosterone levels and erectile function. Erections are initiated when nitric oxide and other neuroendocrine factors induce relaxation of the smooth muscles of the cavernous arteries and tissues resulting in increased penile blood inflow. Testosterone therapy has also shown consistent benefit in improving libido in men with low testosterone levels at baseline, with no additional improvements once testosterone levels are normalized. After a week of treatment, patients on testosterone gel can have their levels checked. Three months after starting testosterone therapy, it is important to monitor the levels of testosterone. The effects of testosterone on upper airway dimensions are not known, but it is likely to contribute to sleep disorder breathing through central mechanisms according to this 1985 study. The adverse effects of testosterone replacement therapy on the liver have been reported. Patients should also be monitored for signs of edema, gynecomastia, sleep apnea, lower urinary tract symptoms, and low BMD. Laboratory parameters that should be monitored before and during treatment include PSA, hemoglobin, hematocrit, lipid profiles, and liver function tests. If the patient is unresponsive or cannot tolerate CPAP, the testosterone must be reduced or discontinued. Rebound of the sperm count to baseline levels occurs within six to 18 months of cessation, and subsequent fertility has been demonstrated.310 Supraphysiologic doses of androgens may cause decreased testicular size, and azoospermia.311 Periodic hematological assessment is indicated (ie, before treatment, then at 3 to 4 months and at 12 mo in the first year of treatment and annually thereafter). Skin-to-skin contact with a man undergoing testosterone replacement therapy could inadvertently and dangerously raise a woman’s testosterone level. Children should never be exposed to testosterone products because they can cause premature puberty and health problems such as liver damage. If you respond poorly to testosterone replacement therapy or would like to explore other options, consult your doctor. While hCG is commonly used as a fertility aid for women, a study published in Cureus in 2022 showed it may increase libido and sexual function in men. Men on testosterone therapy typically report improved mood, reduced anxiety, cognitive benefits and improvement in overall quality of life scores. Men with depressive symptoms that fail to respond to adequate testosterone replacement should also be referred for psychiatric consultation. Men with low testosterone may also experience breast symptoms such as tenderness or gynecomastia as well as testicular atrophy, issues not seen in men with depression. However, due to the nature of the studies, reverse causality cannot be ruled out. Nettleship et al.65 found that testosterone slows atheroma development and reverses lipid deposition in the artery wall. It is believed that this process involves the downregulation of L-type voltage-gated calcium channels61 and upregulation of calcium-activated potassium channels.62 The immediacy of the vasodilation has raised questions as to whether the underlying mechanism involves non-genomic actions of testosterone. BMI, body mass index; Ca, calcium; H, hydrogen; HbA1c, hemoglobin A1c; hs-CRP, high-sensitivity C-reactive protein; K, potassium; O, oxygen; OH, hydroxide; QTc interval, heart-rate–corrected QT interval. Meta-analyses on the topic have also been mixed, with significant differences between the findings of RCTs and observational studies. ❌ Disrupts mood and hormones with fillers "Overpriced hype that doesn't make me feel better—my T levels didn't budge," complained a forum poster, echoing widespread frustration over plateauing results and digestive upset. "Bloating, cramps, nasal congestion—no energy boost, just regret," shared a Yelp user, citing side effects from a 2010 Journal of Dietary Supplements review. 🧪 Boron and Zinc – Underdosed here; while zinc can help deficient men (1996 Nutrition study), Nugenix's blend obscures amounts, rendering them useless. ✔ In our lab analysis, Nugenix showed no measurable T-elevation, aligning with a 2019 USC review that slammed many boosters for lacking supportive ingredients. Some men have a lower than normal testosterone level without signs or symptoms. A blood test is the only way to diagnose a low testosterone level or a reduction in the availability of testosterone. Patients should be very skeptical about herbal testosterone and other “nutraceuticals.” The term nutraceuticals covers dietary supplements, herbal preparations and some foods. All three forms can increase blood pressure resulting in stroke or heart attacks. Cushing’s syndrome happens when you have high levels of cortisol (stress hormone) in your body. An increase in blood pressure may not be noticeable but look out for any of the following symptoms of severely high blood pressure. Call your healthcare provider if your blood pressure increases while using this medicine. Focused on ingredients like L-citrulline, L-arginine, and D-aspartic acid, which influence blood flow and nitric oxide synthesis. They are popular for their holistic approach and minimal side effects. Additionally, social openness about men's health issues has reduced stigma, encouraging proactive care. As a result, more individuals are turning to supplements as a non-invasive way to regain vigor and confidence. Lifestyle factors such as chronic stress, poor sleep, sedentary jobs, and suboptimal diets have contributed to declining energy levels among men globally. In the US, men experience an approximate 15% higher cancer incidence and an approximate 30% higher cancer-related mortality, compared with women. Notably, associations between TT and colorectal cancer retained statistical significance following Bonferroni correction. Overall, we observed no significant relationship between injection/implantation TT and any of the seven cancers. Baseline characteristics of cancer cases and frequency-matched controls in the SEER-Medicare database, 1992–2015. How we evaluated testosterone boosters

Finally, numerous randomized controlled trials (RCTs) have demonstrated that erectile function improves when testosterone is given to men with low testosterone levels 19–24. The evaluation of testosterone levels in men with ED is recommended by the European Association of Urology guidelines and is indicated in select men with ED per American Urology Association guidelines 11, 12. While evaluating neurologic, vascular, and psychologic factors can be difficult during a clinical visit, a hormonal etiology of ED can easily be assessed by measuring morning serum testosterone levels. In this review, we summarize the recent literature examining the relationship between low serum testosterone levels, ED, and decreased libido. While it may improve sexual function, it has little impact on testosterone levels in healthy individuals. In many countries, over-the-counter testosterone boosters do not require approval from health authorities before they are sold. The goal of this article is to provide clear, science-based information on the side effects of testosterone boosters and how to avoid them. This article aims to explore the possible dangers of testosterone boosters and how they can affect the body. You must be over 38, have had your ovaries removed or have suffered with premature menopause to warrant further hormone tests. Our team of healthcare experts and GMC registered doctors are licensed to UK GMC standards. The right doctor will create a customised treatment strategy that aligns with your specific goals and will support you throughout your TRT journey.

Testosterone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

Upon judging the time-course of effects of testosterone on the prostate, it is of note that aging itself is a factor in the rise of both prostate volume and PSA (84), and there is no endpoint in the effects of testosterone on the prostate. The effects of testosterone on red blood cell formation (hemoglobin and hematocrit) are dose dependent (14, 82, 83) while higher age is also a factor (44). Similarly, effects of testosterone administration in hypogonadal men on the ability to process spatial data of visual content were observed within 2 weeks of treatment (80). The mean change in IIEF-EF, however, was greater when data were stratified by baseline testosterone level. It is important to note that men enrolled in this study on average had moderate ED, and so this improvement in erectile function was not considered clinically significant. As the corpus cavernosum fills with blood, the veins that drain the corpus cavernosum are compressed, resulting in maintained turgidity . The IIEF-EF is often used in studies to trend changes in erectile function, with a change of 2 IIEF-EF points being clinically significant for men with mild ED. These risks have been well known since the mid-20th century, and largely deterred doctors from prescribing it. The psychology journals are filled with studies based on samples as small as a few dozen participants, or a few hundred. The records search identified 17,838,316 men who did not supplement testosterone, and 263,579 who did (1.5 percent of the sample). The large majority of those who supplemented T took the hormone in hopes of enjoying the gains advocates have promised and publicized. You should always talk to your physician before beginning any supplement and, in this case, see if they can order testing for your testosterone levels. "Low sex drive can be caused by many things, but the most common cause is low testosterone levels," Elmardi said. For example, Roman and Innerbody Labs are the only two to offer T boosters that include copper as an offset to zinc, which has been shown to deplete copper levels.2 There’s also an opportunity in testosterone-boosting supplements to add ingredients that can account for the potential adverse effects of others. Most men on testosterone replacement therapy will not see a significant increase in blood pressure. This increased oxygen carrying capacity of the blood can improve exercise endurance in men on testosterone. Some men on testosterone therapy will experience a marked increase in estradiol levels. Once testosterone therapy is begun, men require close monitoring and follow-up to reduce potential risks of treatment. The goal of taking testosterone under medical supervision is to restore normal testosterone levels. In the 1940s, researchers discovered that lowering testosterone levels could slow the growth of prostate cancer in some men. Anyone considering testosterone therapy should speak with a healthcare provider to understand the risks and monitor their mental health throughout treatment. Studies have found that testosterone therapy can increase the risk of heart attacks, strokes, and blood clots. While topical testosterone delivery systems avoid first-pass hepatic metabolism, there remains concern regarding TRT in patients with chronic liver disease. The systemic effects of TRT may be exacerbated in men with limited cardiovascular reserve. If patients starting TRT already carry a diagnosis of OSA, physicians should counsel these patients that TRT may worsen their symptoms. While some studies suggested that there is no association between OSA and TRT, others have demonstrated that that OSA occurs in men undergoing TRT and when supplementation is stopped, the OSA resolves. While testosterone exerts a positive effect in men with baseline anemia, it can lead to polycythemia in over 20% of men treated on TRT. TRT involves the administration of exogenous testosterone, either through injections, patches, gels or pellets. These can include hypogonadism, reduced libido, fatigue, muscle weakness and mood disturbances. Here’s everything you need to know about how they work, the potential benefits and side effects to consider. If you take testosterone and didn’t have multiple blood tests and clear deficiency symptoms before you received your prescription, you might want to rethink the use of the hormone. As I write, testosterone is FDA-approved as replacement therapy only for men who have low testosterone levels due to disorders of the testicles, pituitary gland, or brain that cause a condition called hypogonadism. In addition to its mental health impact, supplemental testosterone also thickens the blood, making it more likely to clot, a risk factor for heart disease and stroke. The variability in these reviews demonstrates that physicians should counsel patients to temper their expectations abouttaking these products to boost serum testosterone levels, and even with regards to subjective improvements in symptoms related totestosterone deficiency.

Your doctor will likely measure your testosterone levels at least twice before recommending testosterone therapy.
It is estimated that men in their 70s have mean T levels 35% lower than younger men .
Those low levels cause decreased testosterone and sperm production.
One of the most significant concerns with testosterone supplementation is its potential impact on cardiovascular health.
Most of the ingredients from testosterone boosters that also make their way into male enhancement pills are the ones whose research points toward increased libido and sexual performance.
Testosterone therapy might seem like the ultimate anti-aging formula.
Let’s delve into the importance of consulting a healthcare professional and the differences between FDA-approved treatments and over-the-counter supplements.
Serum T in the OSA group was significantly lower compared with controls, and a statistically significant inverse correlation was found between serum T level and depressive symptoms Bercea et al. 2013.

This article will also address some of the most common questions that people search for online when it comes to testosterone supplements and their side effects. It is important to understand that not all testosterone boosters are the same. Because of this, many turn to testosterone boosters to help regain energy, improve performance, and enhance their physical appearance. Natesto may increase the levels of red blood cells, also called erythrocytosis or polycythemia. Natesto works by adding more testosterone to a person’s body to help them achieve normal levels. Natesto contains testosterone, a sex hormone that is made naturally in the body. Natesto (testosterone) is commonly used to treat low testosterone levels in men caused by certain conditions, such as hypogonadism. Effects of High Testosterone on Mood

Less common or rare

What is Testosterone Replacement Therapy(TRT)?

Our finding of a potential link between exogenous testosterone and melanoma risk provides an interesting parallel to the UK Biobank study, thereby adding credence to the observed association. However, little evidence is available for exogenous hormone use in relation to risks of cancers which are predominant in, or exclusive to, men. Remarkably, however, inverse associations between ever-use of TT and distant-stage prostate cancer have been consistently reported in all prior studies 15, 16, 18. Based on a study from the National Library of Medicine, higher testosterone levels have been linked to increased aggression . Testosterone boosters are supplements that are marketed as a way to increase testosterone levels. Some studies suggest that increasing testosterone levels too much can raise the risk of high blood pressure, blood clots, and heart attacks. Using testosterone boosters continuously without breaks can lead to dependency and increased side effects.

Management Strategies for Polycythemia Induced by Testosterone Therapy

Specializing in Performance Psychology, his expertise is backed by both rigorous study and practical experience. TRT is usually safe, yet it can cause acne, lower sperm count, and raise heart attack and stroke risks. TRT is often for middle-aged men or those with low testosterone. Low testosterone can be caused by underlying medical conditions, prescription medications and testicular failure. If a person or pet comes in contact with the medication, they may have a serious risk of side effects. Despite decades of research on the topic, clinical and preclinical data on the effects of exogenous and endogenous testosterone have produced contradictory and/or inconclusive results. A Swedish study of over 3,000 men with an average age of 75 linked low testosterone and high estradiol levels to an increased risk of PAD. Men who receive androgen-deprivation therapy for prostate cancer drop their testosterone levels nearly to zero, and when that happens, their cholesterol levels rise. Recent clinical trials report that testosterone replacement therapy in older men with low to normal-low baseline testosterone levels result in increased hemoglobin and hematocrit levels Furthermore, Finkle et al. reported an increased risk of non-fatal myocardial infarction in older men during the first 90 days following the initial prescription of testosterone, with a subsequent decline in baseline risk in the 91–180 days after treatment, using a large healthcare database . In line with other studies, the 1-year treatment of older men with low testosterone levels has also failed to demonstrate a definitive effect of testosterone on mood and showed only modest benefit with respect to mood and depressive symptoms . Testosterone is the primary male sex hormone and the reason why men produce sperm and have Adam’s apples. From sinus infections and high blood pressure to preventive screening, we’re here for you. Cleveland Clinic’s primary care providers offer lifelong medical care. Talk with your healthcare provider as soon as possible if you feel like you’re dependent on anabolic steroids. The correlation between high testosterone and high zinc levels is apparent in many studies (10,11,12). Mucuna pruriens (velvet bean) contain L-dopa which can suppressing prolactin, leading to elevated testosterone levels (3). Read on to find out what vitamins, minerals, and herbal extracts work best to boost your testosterone levels. The potential side effects of testosterone supplements, including cardiovascular risks, mood swings, and hormonal imbalances, should not be taken lightly. Testosterone supplements may offer benefits for some individuals, such as increased energy, muscle mass, and libido. Before turning to testosterone supplements, consider other lifestyle changes that can naturally boost testosterone levels. In a 2011 meta-analysis Corona et al's study , found baseline TT was 2.08 nmol/L (95% CI, 3.57 to 0.59) lower in men who developed incident T2DM compared with those who did not. Furthermore, low FT and sex hormone binding globulin (SHBG) have been shown to predict the onset of diabetes in men in up to 10 years of follow-up (odds ratio OR, 1.58 for a decrease of 4 ng/dL FT and OR, 1.89 for a decrease of 16 nmol/L SHBG) . The evidence suggests that low testosterone leads to new onset T2DM and contributes to worsening comorbidities 8,9,10. The link between T2DM and HG is considered bidirectional and conventional management has recovered around lifestyle strategies of weight and exercise which are clearly failing as the prevalence continues to increase . Recent re-classification of HG by the Endocrine Society refers to T2DM related HG as ‘functional’ and some endocrine guidelines suggest that only ‘classical’ HG be treated, despite no published studies demonstrating that this group responds better. Results from these studies indicated that TU increased height velocity and circulating T levels compared to controls. Testosterone may increase the risk of developing prostate cancer. Increased levels of testosterone can lead to increased levels of estrogen. Testosterone may increase a woman's risk for breast cancer, heart disease, and blood clotting. Frequency of outbreaks can increase, dependent on the levels of active testosterone in the body. Prostate cancer is one of the most common cancers among men, and its potential link with testosterone therapy has been extensively studied. While testosterone therapy can provide significant benefits for men with low testosterone, its implications for fertility and reproductive health demand careful consideration and planning. While TRT can significantly improve quality of life for men experiencing symptoms of low testosterone, it can also have profound effects on fertility. While testosterone therapy can significantly enhance the quality of life for men with low testosterone, its relationship with cardiovascular health demands careful consideration. However, some research suggests that testosterone could affect breast cancer in men. There is no strong evidence linking testosterone to testicular cancer, lung cancer, or colon cancer. The withdrawal process can be difficult, leading some people to restart testosterone use to avoid the negative symptoms. Some people feel a strong urge to continue using testosterone even if they experience negative side effects. Many factors can naturally increase testosterone production – including exercise, stress and sex. Not only does testosterone drive sexual development and puberty, it also helps us build lean muscle mass and controls bone growth. But while synthetic testosterone might improve your appearance in the short term, its long-term consequences to your health should not be ignored.

Types of Testosterone Products and Their Different Risk Profiles

Testosterone supplements, especially oral forms such as pills, can have a negative effect on the liver. A doctor can determine if the supplement should be adjusted or stopped to protect overall health. This happens because testosterone affects the way the kidneys handle fluids. This happens because testosterone influences the part of the brain that controls emotions.

Find a healthcare provider

However, accurate comparisons between the 37 human studies were not possiblegiven non-uniform supplementation protocols and sampling timelines. We observed that only 19% of the studies examining the ten most common supplementingredients were conducted in human subjects. Furthermore, all of these supplements were marketed as being produced in ‘FDA Registered Facilities.’ Patientsshould be counseled that the FDA does not formally review and approve supplements in the U.S., and therefore such claims should beviewed with caution. We also noted that despite a variety of marketing approaches among these 5 supplements, several shared identical ingredientprofiles. While the problem ofcontamination is not exclusive to T-Boosters, the use of these products among competitive athletes who routinely undergo testing forbanned substances underscores the need for transparency in labeling the full spectrum of ingredients found in these supplements36,39,40. It is formulated to be the best testosterone booster for the widest audience. We found ourselves wishing to find a testosterone booster that we could recommend more full-throatedly — an affordable supplement that contains clinically relevant doses of ingredients that all carry scientific backing for testosterone enhancement. Though we don't consider it the best testosterone booster, TestoPrime is also great and makes a solid alternative to our top recommendation. The only downside is that dozens of companies are peddling "miracle" supplements, and they can drown out the safer, more effective options on the market. Guidelines from the Endocrine Society say you should not have TRT if you have prostate cancer or breast cancer. You may notice a drop in body fat and a buildup of muscle mass after TRT. If you've been diagnosed with an abnormally low T, testosterone replacement therapy (TRT) offers a lot of benefits. Learn more about hormone health and kidney function from this Piedmont Healthcare resource. The key difference is that these effects are systematically monitored and managed in medical settings. Tell your healthcare provider about all medicines that you take or have recently taken. Your healthcare provider will advise you if you should stop breastfeeding or stop methylprednisolone. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Before starting TRT, your healthcare provider will make sure low testosterone is an accurate diagnosis. TRT has certain risks and benefits, so your healthcare provider will carefully evaluate if it’s safe and right for you. For others, low testosterone might cause changes in sexual function, sleep patterns, emotions and the body. But it can be prescribed if it might have a medical benefit for someone. It's also not for those who've had breast or uterine cancer. More research is needed to find out whether this treatment is safe and effective before menopause. It also can happen early for medical reasons, such as surgery to remove the ovaries. Over-producing female hormones will not get you any closer to your fitness goals. Examples of prohormones are TREN, androstenedione and DHEA. We help our patients move from wellness to greatness, and live the happier, healthier, and more productive lives they deserve. Also, some supplements aren't safe to take with some prescription drugs. A main concern with supplements is that they aren't regulated by the FDA the same way drugs are. Researchers have looked into whether it helps with menopause symptoms, erectile dysfunction, and mental and physical signs of aging, but results have been mixed. Vitamin D. Your body naturally produces vitamin D when your skin is exposed to sunlight. Zinc may promote testosterone production in the testes. It likely results in little to no difference in treatment withdrawals due to adverse events, prostate-related events, or LUTS. We are very uncertain about the effect of testosterone on treatment withdrawal due to adverse events. We are very uncertain about the longer-term effects of TRT on erectile dysfunction assessed with the IIEF-EF (MD 4.20, 95% CI -2.03 to 10.43; 1 study, 42 participants; very low CoE). You will be given the Medication Guide when you begin treatment with testosterone injection.Read the information carefully and ask your doctor or pharmacist if you have any questions. Because of the risks of serious breathing problems and allergic reactions, testosterone undecanoate injection (Aveed®) is only available through a special program.This program is called the Aveed® REMS. If you use coumadin or warfarin to thin your blood, this product may increase the effectiveness of your blood thinner. Check your blood sugar levels regularly to make sure your blood sugar is not going too low. Most of the testosterone is produced in the ovaries. Women and people assigned female at birth do produce testosterone as well as estrogen, though the amounts of testosterone are much smaller than those produced by men. Testosterone replacement therapy for women It's natural for testosterone to decline as you age and not necessarily a reason for TRT. But some 1.75 million prescriptions for testosterone products were written by American doctors in 2002, at a cost of $400 million — and the numbers have continued to soar. The FDA has received reports of premature puberty and behavioral changes in children who have inadvertently come into contact with a man's testosterone gel. A safe testosterone pill has not yet been approved in the U.S.

The 7 Best Testosterone Boosters of 2026: Tested and Reviewed

To minimize the risk of side effects, consult with a healthcare professional, choose a reputable brand, follow the recommended dosage, and monitor your body's response to the supplement.
However, little evidence is available for exogenous hormone use in relation to risks of cancers which are predominant in, or exclusive to, men.
If you are taking testosterone boosters, it is important to watch for warning signs that could indicate heart problems.
A condition in which our body stops producing testosterone is called hypogonadism.
A person with testosterone deficiency is more likely to suffer from depression or anxiety.
Always look at testosterone solution before you inject it.
The best candidates for treatment may be hypogonadal men who are currently taking an existing antidepressant with inadequate response.171–173 Additional studies have been recommended incorporating vitality, well-being and/or quality of life as end points.

A high-quality man booster typically includes natural aphrodisiacs like horny goat weed, maca root, and L-arginine, which support blood flow, energy, and libido 1. Cleveland Clinic’s experts can help balance your hormones. But you should address symptoms that interfere with your quality of life.

They should also be checked for sleep apnea symptoms, lower urinary system symptoms, or low bone mineral density.
She also would like to explore disseminating handouts to her patients with more accurate information in the hopes that it encourages patients to seek a medical professional for low testosterone issues.
Each year after the age of 25 the normal levels of testosterone decrease rapidly.
Potential risks and side effects, such as acne, fluid retention, and an increased risk of heart disease, may accompany these supplements.
A better understanding of how your body works will help you cope with hormonal fluctuations.
Testosterone leads to an increase in hemoglobin by as much as 5-7%1,25 through its effect on the production of erythropoietin, which can dramatically improve symptoms of anemia in men.40,41
Short acting injectable testosterone can be adjusted to meet individual testosterone requirements.
The company certainly is one of many to look at for effective treatments in Eastern medicine, but it goes the furthest to include a wide variety.

Women administering any form of testosterone must be aware of the potential of developing typically male characteristics such as facial hair, deepening of the voice, and changes in the skin. This particular testosterone side effect is difficult to avoid and must be taken into careful consideration by men interested in growing their families. Your AAI physician will supply you with the medications necessary to maximize the effects of your protocol, ensuring a safe, effective program with little to no side effects. This is a very dangerous possible side effect of testosterone injections, and it must not be taken lightly. This is why educating yourself into the purpose of each supplement is critical, because a lack of understanding could lead to a patient making the mistake of skipping that portion of the therapy. “Anabolic” refers to tissue building (mainly muscle), and “androgenic” refers to a group of sex hormones called androgens. This is often related to how your body converts testosterone to oestradiol. That’s why your doctor will evaluate your current health and medical history, as well as the results of any tests they run, when deciding whether to prescribe it to you. For instance, losing weight and stopping smoking may reduce your risk of blood clots. For example, it’s recommended to check red blood cell count and testosterone around the 3, 6, and 12-month points after starting, then every 6 months thereafter. All forms of OTC testosterone boosters offer their own unique health risks. Some OTC testosterone boosters may be safe when used in moderation, but they cannot permanently raise or maintain your testosterone levels. Hormone therapy produced a modest increase in blood flow to the heart muscle by widening healthy, but not partially blocked, coronary arteries. Testosteroneboosters can cause the testes to shrink in size, and possibly cause infertilitydue to a reduced sperm count. Men takingboosters have reported some skin problems. Many of these sideeffects are also side effects of synthetic steroids, but your chances ofincurring them are higher on the synthetic drug. If you have a strong family history of prostate or breast cancer, it is important to talk to a doctor before considering any testosterone treatment. When a person takes testosterone supplements, their brain senses high levels of testosterone in the blood. However, many people take these supplements without a medical need, hoping to increase muscle mass, boost energy, or improve athletic performance. Crucially, testosterone supplements turn off the normal drives for this hormone in the brain. Testosterone has psychological effects, too – including increased aggression, depression and anxiety. Initially, it may lead to an increase in sex drive and help your body build more muscle mass over several months. This trial concluded that 18 weeks of TRT improved several important cardiometabolic parameters, including insulin resistance, decreased liver fat, and increased lean muscle mass, but did not differentially reduce overall weight or the metabolic syndrome. Although IPSS scores were shown to significantly improve with TRT over the first 5 years of therapy, one might postulate that if prostate volume continues to increase with continued use of TRT, then LUTS may subsequently worsen after a period of improvement. People with hepatitis, cirrhosis, kidney disease, or a history of liver problems should avoid testosterone supplements unless a doctor advises otherwise. People with a history of heart disease or stroke should not take testosterone supplements unless prescribed by a doctor, and even then, they must be monitored closely. Testosterone supplements may seem like a quick and easy way to boost energy, improve muscle mass, and enhance overall well-being. If you or someone you know is struggling with testosterone dependence, seek medical help. Time-course of effects on muscle mass/strength

Time-course of effects on muscle mass/strength

The American Urological Association guidelines emphasize that medical testosterone therapy should be reserved for documented deficiency with symptoms, not simply for enhancement, and should always include kidney function monitoring as part of the standard protocol. A geriatric medicine study in the Journal of the American Geriatrics Society demonstrated that adults over 65 using testosterone boosters experienced a 2.3-fold higher rate of kidney function decline compared to younger users, emphasizing the need for particular caution in this population. Certain populations require extra caution regarding testosterone boosters and kidney health. Testosterone plays an essential role in male sexual functions like sperm production and erections, while it's also essential for maintaining muscle strength and bone density. That said, the published review looking at this particular event couldn't confidently conclude that the supplement caused the issue as the user declared he used it a further two times without any ill effects. The patient underwent a battery of lab tests and an abdominal ultrasound, which revealed elevated levels of liver enzymes ALT and AST. We wanted to know the effects of testosterone replacement therapy on men with erection problems. In the short term, testosterone replacement therapy has a minimal impact on erectile function, sexual quality of life, and cardiovascular mortality, with few side effects. However, it is unclear how effective this treatment is and if it has unwanted harmful effects (adverse effects), especially on heart health. It is commonly used in men with low testosterone levels who experience erection difficulties. It’s at the core of your body’s ability to build muscle, shed fat, and support a high libido and strong sexual function. As a natural body builder, Bennett enjoys the ongoing pursuit of health and wellness in all aspects of life. DHT is responsible for such side effects as acne, prostate enlargement and hair loss. Aromatase is the enzyme that converts testosterone into the female hormone estrogen 3. El-Zawahry says any exercise benefits your general health and helps you maintain a healthy body weight and T level. Testosterone levels usually increase transiently after weights and intense physical activity about 15 minutes to an hour after the workout, Cherullo said. But no exercise is going to drive your T levels through the roof, and it won’t be a prolonged increase. Obesity is linked to low testosterone and other health problems. Testosterone as a sex hormone plays an important role in sexual function, and 1-year replacement therapy in hypogonadal young men with a mean age of 55 years has been shown to significantly improve sex drive and energy . In this study, subjects with medications affecting bone, as well as those with severe illness, were excluded, and no information on the health status of the enrolled population was provided. However, the effect and consequences of long-term testosterone replacement therapy, specifically in older men, remain significantly understudied. But these supplements may also come with serious health risks, especially when it comes to heart health. While some men tolerate these supplements well, others may experience a range of side effects that impact their health and quality of life. Testosterone boosters can have real effects on the body, both positive and negative. In some cases, prolonged use of testosterone boosters can lead to erectile dysfunction or reduced sperm production. A good testosterone booster will deliver mg of zinc per day, hitting your daily intake requirements. The precise dose of a testosterone booster for maximum efficacy is obviously going to depend on the specific formulation. The first are the immediate adverse effects of the ingredients. This relationship is especially strong in older men–the biggest group at risk for low T. Doctors study its levels to screen for prostate issues, including prostate cancer, inflammation, and enlargement. Testosterone Replacement Therapy may also cause an increased risk of skin reactions depending on the type of testosterone delivery method you use. TRT aims to restore testosterone to optimal levels using bioidentical testosterone, improving symptoms such as fatigue, decreased libido, and loss of muscle mass. These effects are due to increased tubule permeability from excessive nitric oxide levels as well as enhanced expression of Rho kinase signaling pathways within kidney tissues. Inhibiting aromatase seems to contribute to these side effects via increased 5-alpha reductase enzyme. 6-OXO increased free testosterone by 90 percent, accompanied by a 192 percent increase in DHT 3. However, it also increased the production of DHT (dihydrotestosterone) by a whopping 566 percent. Men considering TRT should discuss possible risks with their doctor, especially if they have any cardiovascular disease risk factors. The researchers pointed out that their findings do not apply to men who do not have a testosterone deficiency. A new study suggests not, although with some caveats. Neveruse a testosterone booster continuously. Others buy testosterone illegally from online sources or underground markets, which increases the risk of taking unsafe products. Psychological dependence is more common in people who use testosterone for non-medical reasons, such as bodybuilding or athletic performance. Long-term testosterone use can change how the body produces hormones. Some people who misuse testosterone supplements struggle to stop using them, even when they experience harmful side effects. However, healthy habits that boost testosterone, like getting good sleep and exercising, certainly won't hurt. There aren't studies to back up using it for other symptoms. It's important for your sex drive, bone and muscle health, energy, and mood. Concerns over possible health hazards have prompted the FDA to investigate the risk of heart attack, stroke, and death in men taking FDA-approved testosterone products. Indeed, recent evidence shows that nearly a quarter of men with a prescription for testosterone have never even had their hormone levels checked. A good night’s sleep may help to prevent low testosterone levels. On PubMed, 24.8% of supplements had data showing an increase in T with supplementation, 10.1% had data showing a decrease in T, and 18.3% had data showing no change in T. Many questions in the treatment of hypogonadism remain unanswered, and there is a need for large clinical trials; or at least a meta-analysis of the extensive short-term data combined with analysis of long-term clinical experience which many physicians working in the field now have; to assess the long-term benefits and risks of TRT in older men with late-onset hypogonadism. If there is no improvement of symptoms and signs, treatment should be discontinued and the patient investigated for other possible causes of the clinical presentations. Before starting patients on TRT, health care providers must rule out contraindications to treatment (Table 5). BMD of lumbar spine and/or femoral neck should be measured at baseline every 1 to 2 years of testosterone therapy in hypogonadal men with osteoporosis or low trauma fracture. Stay away from alcohol, sugary foods, and meats that contain antibiotics and hormones, since these foods can cause fluctuations in your testosterone. Over time, your body may stop producing testosterone on its own and come to rely on OTC supplementation. Using OTC testosterone pills regularly can cause your body to build a tolerance to these substances. Are testosterone supplements safe? For instance, many boosters contain ingredients like valerian root that indirectly boost testosterone by helping you sleep better at night. Nearly all of these studies were not specifically designed to address the onset or time-dependency of effects of testosterone, nevertheless a number of controlled studies with different design and scheduled follow-up, allow a reasonable estimation. They originate from studies analyzing the effects of testosterone administration to hypogonadal men or, alternatively, from studies on androgen deprivation. The effect on your blood pressure may depend on your own health, whether you have any heart disease or high blood pressure, and how much testosterone you take. What happens to your body when you start testosterone replacement therapy? Before prescribing testosterone, your doctor should check your testosterone levels and make sure your low T is not due to something else, like an illness. In some cases, we also included ingredients designed to maximize the potential of our testosterone-boosting ingredients (like black pepper extract, which doesn’t boost testosterone but does improve the absorption of other ingredients).40 So we decided to create a testosterone support supplement that could fill the gaps and offer more men the highest likelihood of success. After spending the better part of a decade researching low testosterone and the different ingredients various companies use to address it, we’ve learned which ones should work and which ones probably won’t. There are reported instances of early-onset puberty and unexpected hair growth in children unknowingly exposed to testosterone-boosting gels. The most common side effects of testosterone boosters include acne, fatigue, mood changes, sleep disturbances, and digestive issues. While testosterone boosters are generally considered safe, some users may experience side effects, which can range from mild to severe. While TRT is an effective treatment for low testosterone levels, its potential to induce polycythemia necessitates careful patient selection, monitoring, and management. The primary concern with polycythemia is the increased risk of blood clots, which can lead to serious cardiovascular events such as heart attack or stroke. However, like any medical treatment, TRT is not isolated in its effects and can interact with other medications and pre-existing health conditions. However, women considering this option should be warned that there are currently no testosterone products approved by the U.S. He is the CIO of a small government agency and a dedicated weightlifter with extensive study of nutrition, supplementation and training protocols. Sexual desire and performance requires both estrogen and testosterone. This is because these types of supplements work by reducing estrogen. Caused by an imbalance in the testosterone to estrogen ratio, gyno can be difficult to reverse and may require surgery. While it may slightly increase libido, it’s not been shown to impact testosterone levels at all. D-Aspartic Acid – this amino acid has one study that showed a correlation of moderately increased T levels in untrained individuals. Many men are deficient in testosterone levels, and normalizing or optimizing testosterone can be done with some real benefits, so there is a real market for T boosters these days.

One of the most well-known mental health effects of testosterone supplements is increased aggression.
One of the most well-known side effects of long-term testosterone use is its effect on male fertility.
Tell your healthcare provider about any infections you may have.
Testosterone boosters work on different parts of your endocrine system, depending on their ingredients.
Animal studies suggest that testosterone increases serotonin levels in the brain perhaps explaining it’s positive effect on depression.
Learn about the potential side effects of testosterone boosters, including liver damage, heart risks, and more.

Some large observational and randomized studies have supported this conclusion, whereas others have suggested a cardioprotective role for testosterone. Atlhough the protective effect of estrogen on cardiovascular health is well-established,3 the effect of testosterone is less clear. Cardiovascular disease (CVD) is the leading cause of death globally.1 Various factors increase the risk of CVD, including diabetes, obesity, hypertension, dyslipidemia, and increasing age. Additional research suggests that testosterone shortens the heart-rate–corrected QT interval, improves glycemic control, induces vasodilation, is prothrombotic, and has anti-obesity effects, whereas associations with atherosclerosis and inflammation are less clear. MedicineNet does not provide medical advice, diagnosis or treatment. At 1 year, the 23 men randomized to 250 mg of testosterone enanthate every 4 weeks reported significant improvements in IPSS and maximal urinary flow rates compared with baseline and controls. As the population continues to age, both the incidence of BPH and late-onset male hypogonadism will continue to rise and practitioners will need to be comfortable with counseling men on the effect of TRT on the prostate. We know the prostate to be an androgen-dependent gland and conversely, anti-androgen agents can decrease prostate volume in patients with BPH. The goal of this review is to highlight the risks and summarize the current literature on safety of TRT. The chances of dealing with risks are higher when you choose to opt for a treatment at the right time. It is best to use a testosterone supplement when experiencing any symptoms that might signal deficiency. Sleep and normal levels of testosterone have a direct relation. Other possible risks include worsening symptoms of benign prostatic hypertrophy, liver toxicity, hyperviscosity, erythrocytosis, worsening untreated sleep apnea or severe heart failure. It's important to understand that medication from unauthorised providers can carry serious health risks. For both cis and trans men, testosterone supplements can be taken as tablets, injections, skin gels, or patches you apply to your skin. SIXSTAR Testosterone Booster is formulated with a precise dose of the mineral boron, which is shown in human clinical research to increase active (free) testosterone in just 7 days. It is possible that pre-existing heart disease may have contributed to worse outcomes with testosterone treatment. While the benefits of taking testosterone likely outweigh the risks for hypogonadal men, the same may not be true for aging men who take testosterone because they think it will make them look and feel younger. Erythrocytosis can occur with all testosterone formulations but the incidence may be higher with testosterone injections. More severe cases may require management by dermatology using oral antibiotics or isotretinoin therapy. In most cases, the acne is mild and can be managed with topical skin washes such as CLn body or facial wash. Testosterone therapy can stimulate the sebaceous glands of the skin leading to acne. You can see our favorite at-home testosterone tests in our comprehensive guide, many of which you can get with a discount as an Innerbody reader. But for those who aren’t sure whether their testosterone is low, at-home tests make it tremendously easy to measure their levels. If you notice any of these symptoms, it doesn't necessarily mean you should jump right into a testosterone booster regimen. Clinically low testosterone is also known as male hypogonadism, and it causes numerous symptoms. 'Overconsumption of high fat, processed and high sugar food can lead to increased deposition of fat in the abdominal region,' says Dr Pratsides. 'Poor lifestyle can mimic the symptoms of low testosterone and can actually cause low testosterone as well,' says Hodzovic. While steroids like DHEA can boost testosterone, if they're used in the wrong dosages or by people who don't need them, they can raise T-levels far beyond the normal (and safe) range. This is known as hypogonadotropic hypogonadism because there are low levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Primary hypogonadism happens when something is wrong with your testicles that doesn’t allow them to make normal levels of testosterone. And other studies have estimated that more than 8% of men aged 50 to 79 years have low testosterone. It’s difficult for researchers to estimate how common low testosterone is since different studies have different definitions for low testosterone. Providers also take symptoms into consideration when diagnosing low testosterone. However, a recent large clinical trial was still not powered enough to determine whether testosterone replacement therapy may impose a risk of developing prostate cancer in older men. In another retrospective national cohort study, testosterone replacement also increased the risk of death, myocardial infarction, and stroke in older men with a pre-existing cardiac condition and those who underwent cardiac angiography . In contrast, a clinical trial that included older men over 65 years of age with serum testosterone levels below 350 ng/dL and mobility limitations was stopped early due to the increased incidence of cardiovascular events in the treated group. When evaluating the effects of testosterone on the progression of atherosclerosis, a 3-year clinical trial in older men with serum testosterone levels at recruitment of 100–400 ng/dL showed that testosterone treatment had no effect on the rates of change in common carotid artery intima-media thickness, or coronary calcium . For example, the earlier study by Snyder et al. evaluated the effect of testosterone treatment, in the form of a patch, in 54 older men with total serum testosterone levels below 350 ng/dL over a period of 3 years. Check with your doctor right away if you have convulsions (seizures), fast, racing, or uneven heartbeat, muscle spasms (tetany), tremors, or unusual tiredness or weakness. This medicine may cause hypomagnesemia (low magnesium in the blood). Taking this medicine for a long time may make it harder for your and your child's body to absorb vitamin B12.