Melatonin shifts human circadian rhythms according to a phase-response curve. Over-the-counter melatonin products and contamination. Low melatonin production in infants with a life-threatening event. Melatonin supplements can come in many forms such as tablets or sprays, but more recently, melatonin gummies have been a popular sleep support option. Some studies suggest that melatonin gummies showed no drastic side effects in children, so they may be considered safe for shorter periods. Lemoine P, Nir T, Laudon M, Zisapel N. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. Lissoni P, Barni S, Mandala M, et al. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solic tumor patients with poor clinical status. Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus Aloe vera in untreatable advanced solid neoplasms. Meeking DR, Wallace JD, Cuneo RC, et al. Exercise-induced GH secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects. Dollins AB, Zhdanova IV, Wurtman RJ, et al. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. O'Callaghan FJ, Clarke AA, Hancock E, et al. Use of melatonin to treat sleep disorders in tuberous sclerosis. Commentz JC, Uhlig H, Henke A, et al. Melatonin and 6-hydroxymelatonin sulfate excretion is inversely correlated with gonadal development in children. These gummies also contain a combination of relaxation-promoting ingredients. Alternatively, you may consider using the ShutEye® app to solve your sleep difficulties. Adults and parents need to follow the exact instructions and dose as stated on the supplement label to prevent this from occurring. However, that being said, there is still a small possibility, especially for children. Our team has reviewed hundreds of sleep accessories and supplements, and helped nearly 132,000 shoppers find their new favorite product. She has been writing, editing, and researching sleep-based content for over a year, and her sleep recommendations and insights have appeared in Bustle, Livingetc, and Authority Magazine. Boafo, Addo., et al. “Could long-term administration of melatonin to prepubertal children affect timing of puberty? She has personally tested over two dozen mattresses, and countless other sleep products. Lindsay Boyers is a functional nutritionist with extensive experience in sleep, supplements, and other areas of health and wellness. The effects of oral melatonin on skin color and on the release of pituitary hormones. Arangino S, Cagnacci A, Angiolucci M, et al. Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. Jorgensen KM, Witting MD. Does exogenous melatonin improve day sleep or night alertness in emergency physicians working night shifts? Cagnacci A, Krauchi K, Wirz-Justice A, Volpe A. Homeostatic versus circadian effects of melatonin on core body temperature in humans. Carman JS, Post RM, Buswell R, et al. Negative effects of melatonin on depression. Zhdanova IV, Wurtman RJ, Morabito C, et al. Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans. Zhdanova IV, Wurtman RJ, Lynch HJ, et al. Sleep-inducing effects of low doses of melatonin ingested in the evening. Improvement of sleep quality in elderly people by controlled-release melatonin. In addition to paying attention to dosages, read through customer reviews to see if there are repeated mentions of side effects. Because melatonin is classified as a dietary supplement, it’s not regulated by the FDA24. However, if you only want melatonin, double-check the label so you know exactly what you’re getting. In some cases, active ingredients can work synergistically, making the supplement more effective. A randomised study with subcutaneous low-dose interleukin 2 alone vs. interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma. Lissoni P, Barni S, Brivio F, et al. A biological study on the efficacy of low-dose subcutaneous interleukin-2 plus melatonin in the treatment of cancer-related thrombocytopenia. Randomized study with the pineal hormone melatonin versus supportive care alone in advanced nonsmall cell lung cancer resistant to a first-line chemotherapy containing cisplatin. However, research findings show that extended-release supplements and higher doses of melatonin are more likely to result in side effects. Lissoni P. Modulation of anticancer cytokines IL-2 and IL-12 by melatonin and the other pineal indoles 5-methoxytryptamine and 5-methoxytryptophol in the treatment of human neoplasms. Treatment of cancer chemotherapy-induced toxicity with the pineal hormone melatonin. Fischer T, Bangha E, Elsner P, et al. Suppression of UV-induced erythema by topical treatment with melatonin. What Are Side Effects of Melatonin Gummies? The efficacy and safety of exogenous melatonin for primary sleep disorders. Van Heukelom RO, Prins JB, Smits MG, Bleijenberg G. Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion. Melatonin for treatment of sleep disorders. Studies of the interactions between melatonin and 2 Hz, 0.3 mT PEMF on the proliferation and invasion of human breast cancer cells. “There is research showing that melatonin can be beneficial for children with autism or ADHD who have sleep disruption,” said Dr. Shelby Harris, a licensed clinical psychologist. Just Nutrients Melatonin Gummies is our pick for the best high-dose melatonin gummy, packing 20 milligrams of melatonin per serving with solid customer reviews. “Each gummy only has 1 milligram of melatonin, which is my preferred low dose because it doesn’t hit me like a train and leave me with psychedelic dreams and morning confusion,” she said, giving the gummies a 5 out of 5 for side effects. What Are Natural Vitality Sleep Gummies Made Of? Singh, P., Bhargava, V. K., and Garg, S. K. Effect of melatonin and beta-carotene on indomethacin induced gastric mucosal injury. Kaptanoglu, E., Palaoglu, S., Demirpence, E., Akbiyik, F., Solaroglu, I., and Kilinc, A. Different responsiveness of central nervous system tissues to oxidative conditions and to the antioxidant effect of melatonin. Bilici, D., Akpinar, E., and Kiziltunc, A. Protective effect of melatonin in carrageenan-induced acute local inflammation. Lee, Y. M., Chen, H. R., Hsiao, G., Sheu, J. R., Wang, J. J., and Yen, M. H. Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. As for taste, Kate rated them a 4 out of 5, explaining, “These aren’t the best-tasting gummies I’ve ever had, but they are pretty good! While an affordable option for many, it’s important to note that not everyone will have the same experience with such a high dose. Cait described them as “a delicious strawberry candy” and admitted she had to resist snacking on one in the middle of the afternoon. Lunakai Low Dose Melatonin Gummies provide 1 milligram of melatonin, making them a good alternative if your child doesn’t need the added botanicals. Cait’s 7-year-old tester described the gummies as “little bouncy pillows” with a fruity flavor she didn’t want to stop eating, earning a perfect 5 out of 5 for taste and swallowability. Because they’re sweetened with sugar and tapioca syrup, they contain 2 grams of added sugar per serving, which is pretty standard for sugar-sweetened gummies. Each gummy has 1 milligram of melatonin so you can dose appropriately depending on your child’s age. The gummies are made with melatonin, honey, sucrose, glucose syrup, water, pectin, natural flavors, sodium citrate, and fruit and vegetable juice for color. These gummies are also allergen-friendly, so they’re safe for children with dietary restrictions. Two gummies provide 3 milligrams of melatonin. Ninomiya, T., Iwatani, N., Tomoda, A., and Miike, T. Effects of exogenous melatonin on pituitary hormones in humans. Wakatsuki, A., Okatani, Y., Ikenoue, N., Kaneda, C., and Fukaya, T. Effects of short-term melatonin administration on lipoprotein metabolism in normolipidemic postmenopausal women. Graw, P., Werth, E., Krauchi, K., Gutzwiller, F., Cajochen, C., and Wirz-Justice, A. Early morning melatonin administration impairs psychomotor vigilance. This is so that they get the optimal rest that they need and won’t feel morning grogginess.Many gummy supplements are sub-par, but Olly Sleep has high-quality ingredients and an effective dose of melatonin without too much added sugar.These gummies have a 4.5 out of 5 average rating on the brand’s website.Alternatively, you may consider using the ShutEye® app to solve your sleep difficulties.Cagnacci A, Krauchi K, Wirz-Justice A, Volpe A. Homeostatic versus circadian effects of melatonin on core body temperature in humans. SleepFoundation.org does not provide medical advice, diagnosis, or treatment options. Always consult your doctor before taking a new medication or changing your current treatment. Get personalized guidance from the experts who know sleep best. Join our Sleep Care Community — a trusted hub of sleep health professionals, product specialists, and people just like you. If you have general questions about how to get better sleep, consider keeping a sleep diary and make an appointment to talk with your doctor. If you’d rather get your full 5-milligram dose from a single gummy, Natrol Melatonin is a strong pick — and one that’s easier on the wallet. Future Kind Vegan Melatonin Sleep Gummies stand out as the best-tasting melatonin gummy we tested, especially for those who don’t want an overly sweet bite at night. These delicious gummies are vegan and cruelty-free, and provide dosing flexibility for those who are sensitive or new to melatonin supplementation. We evaluated each gummy not only on how well it supported sleep, but also on how practical and enjoyable it was to take consistently. Every melatonin gummy in our list was selected based on our testers’ hands-on experiences, with added insight from our chief medical advisor, Dr. Raj Dasgupta, MD, FACP, FCCP, FAASM. Dericks-Tan, J. S., Schwinn, P., and Hildt, C. Dose-dependent stimulation of melatonin secretion after administration of agnus castus. Inhibitory effect of melatonin on morphine withdrawal syndromes and the content of NO in plasma and brain tissue in morphine dependent mice. Wang, F., Li, J., Wu, C., Yang, J., Xu, F., and Zhao, Q. The GABA(A) receptor mediates the hypnotic activity of melatonin in rats. And Tan, D. X. What constitutes a physiological concentration of melatonin? While the FDA doesn’t regulate melatonin gummies directly, it oversees these regulations, which ensure high-quality manufacturing. To reduce the risk of potential side effects, start with gummies with smaller doses, around 1 milligram per serving, and work your way up, as needed. For melatonin gummies, that means around 1 to 5 milligrams of melatonin for most adults. Unlike capsules or tablets, melatonin gummies typically contain sugar or some sort of sweetener to make them more palatable. That said, in our testing, despite the high 20-milligram dose, Kenny and other online users found the side effects to be generally mild. There’s less than 1 gram of added sugar per gummy, much lower than most competitors. Although results may differ from person to person, tester Cait Giddings found the lower dose easier to tolerate. Dr. Shelby Harris explains, “Some people suggest that long-term use makes your own brain reduce its natural melatonin production, but the reality is that this hasn’t been routinely proven in research. These over-the-counter supplements are available in various forms like capsules, tablets, and liquids, but many people prefer chewable gummies for their ease of use or simply for a tastier, more enjoyable way to take melatonin. Melatonin7 might be one of the most popular sleep supplements, but it’s also a naturally occurring hormone that regulates the sleep-wake cycle. Choosing the right melatonin gummy begins with understanding how it works and finding a product that supports your sleep goals and lifestyle. Melatonin gummies should support restful sleep, not leave you groggy or uncomfortable the next day. If you’re new to melatonin, it’s best to start with a lower dose and gradually increase intake as needed, based on recommendations from your doctor. For long-term relief, you may want to make some lifestyle changes to help increase your natural production of melatonin. While supplements can provide an exogenous source of melatonin, they don’t actually get to the root cause of the issue. Before deciding on a melatonin gummy, read what other customers had to say about their experiences. Instead of looking at the total cost of a melatonin supplement, you want to consider the cost per serving, since bottle sizes can vary. When selecting melatonin gummy formulations, we focused on both dosage and ingredient quality. We selected and tested melatonin gummies through hands-on experience and thorough evaluation, considering key criteria such as formulation, price, overall effectiveness, and more. Each gummy provides 1 milligram of melatonin along with immune-supporting ingredients like zinc, vitamin C, vitamin D3, and black elderberry — especially useful if your child has a cold. We didn’t include it in the main roundup because we already featured high-dose options that meet the needs of those requiring stronger melatonin, and other choices offered lower sugar and better value. Karasek, M., Kowalski, A. J., and Zylinska, K. Serum melatonin circadian profile in women suffering from the genital tract cancers. Kitajima, T., Kanbayashi, T., Saitoh, Y., Ogawa, Y., Sugiyama, T., Kaneko, Y., Sasaki, Y., Aizawa, R., and Shimisu, T. The effects of oral melatonin on the autonomic function in healthy subjects. Norman, T. R., Piccolo, J., Voudouris, N., and Burrows, G. D. The effect of single oral doses of zopiclone on nocturnal melatonin secretion in healthy male volunteers. Bartsch, H., Buchberger, A., Franz, H., Bartsch, C., Maidonis, I., Mecke, D., and Bayer, E. Effect of melatonin and pineal extracts on human ovarian and mammary tumor cells in a chemosensitivity assay. They’re also suitable for a wide range of dietary restrictions, so they could work well for many people. They also contain natural flavors and colors, plus pectin, citric acid, sodium citrate, and organic sunflower oil, which contribute to texture and shelf-life. They’re sweetened with a combination of sugar alcohols (maltitol, erythritol, and xylitol) and organic stevia. They’re also gluten-free, dairy-free, nut-free, and soy-free to accommodate a wide range of dietary restrictions and preferences. This makes them suitable for vegan consumers since traditional gummies are not vegan-friendly. It’s also made with natural ingredients and made in allergen-free, cGMP-certified facilities in the U.S. While most studies are on the juice and not the powder, there is some evidence that tart cherries can help regulate circadian rhythm and boost sleep quality8. This is a great starting dose for people who are new to melatonin or for those who prefer not to take too much at one time. If you’re new to melatonin, you may want to try a lower-dose option, like the Goli Dreamy Sleep Gummies. Garfinkel D, Zisapel N, Wainstein J, Laudon M. Facilitation of benzodiazepine discontinuation by melatonin, a new clinical approach. There is interest in using melatonin for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful. Your daily habits and environment can significantly impact the quality of your sleep. And Elmer, G. W. Update on natural product--drug interactions.Whether you need expert sleep advice for your insomnia or you’re searching for the perfect mattress, we’ve got you covered.Cheung, R. T. The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion.Lemoine P, Nir T, Laudon M, Zisapel N. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects.Alongside the 5 milligrams of melatonin, each gummy provides 10 calories and just 1 gram of added sugar — a lower amount than many competitors.Edwards, R. B., Manzana, E. J., and Chen, W. J. Melatonin (an antioxidant) does not ameliorate alcohol-induced Purkinje cell loss in the developing cerebellum.Some melatonin gummies offer as much as 10 milligrams of melatonin per serving, but a higher dose doesn’t necessarily mean it’s more effective. Why Olly Sleep Earned Best Value Melatonin Gummy To get, and maintain, a cGMP certification, the FDA regularly inspects the facilities where supplements are made to ensure quality and safety. This will ensure that the supplement contains the listed concentration of melatonin and that it’s not contaminated with any unknown ingredients. When it comes to melatonin specifically, research shows that the concentration of the supplement can range from -83 percent to 478 percent27 of what’s actually listed on the label. Children and adolescents should take 0.5 to 3 milligrams and 3 to 5 milligrams, respectively.1 When choosing a melatonin gummy, it’s best to buy products that have third-party certification from well-known programs, like the U.S. Unlike capsules or tablets, melatonin gummies typically contain sugar or some sort of sweetener to make them more palatable.UpToDate delivers evidence-based clinical decision support that is clear, actionable, and rich with real-world insights.View Source .Jones MP, Melan MA, Witt-Enderby PA. Melatonin decreases cell proliferation and transformation in a melatonin receptor-dependent manner.While supplements can provide an exogenous source of melatonin, they don’t actually get to the root cause of the issue.Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia.Solmaz, I., Gurkanlar, D., Gokcil, Z., Goksoy, C., Ozkan, M., and Erdogan, E. Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures.MedicineNet does not provide medical advice, diagnosis or treatment.Because of this, it’s important to work with your pediatrician to make sure the dosage and timing of melatonin is appropriate for your child.You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.They also contain 5 milligrams of melatonin per two-gummy serving, which is on the high end of the effective dose range1 for adults. Lower dosages can be just as effective as higher ones, and most doctors recommend taking between 0.3 to 5 milligrams38 before bedtime. Is the company well-known with a good track record of making high-quality products? Do they work to resolve complaints? Why Goli Earned Best Low-Dose Melatonin Gummy We’ve tried a lot of melatonin supplements and we’ve even made our own. Since supplements vary widely, it’s best to start low and choose a product that’s third-party tested for purity, safety, and quality. The most effective melatonin is the one that meets your unique needs, starting with the right dose and a form you’ll actually take. Fischer, T. W., Scholz, G., Knoll, B., Hipler, U. C., and Elsner, P. Melatonin suppresses reactive oxygen species in UV-irradiated leukocytes more than vitamin C and trolox. Gulcin, I., Buyukokuroglu, M. E., Oktay, M., and Kufrevioglu, O. I. On the in vitro antioxidative properties of melatonin. Edwards, R. B., Manzana, E. J., and Chen, W. J. Melatonin (an antioxidant) does not ameliorate alcohol-induced Purkinje cell loss in the developing cerebellum. Antolin, I., Mayo, J. C., Sainz, R. M., del Brio, Mde L., Herrera, F., Martin, V., and Rodriguez, C. Protective effect of melatonin in a chronic experimental model of Parkinson's disease. Ravindra, T., Lakshmi, N. K., and Ahuja, Y. R. Melatonin in pathogenesis and therapy of cancer. Turkistani, A., Abdullah, K. M., Al Shaer, A. A., Mazen, K. F., and Alkatheri, K. Melatonin premedication and the induction dose of propofol. Yi, C., Pan, X., Yan, H., Guo, M., and Pierpaoli, W. Effects of melatonin in age-related macular degeneration. Revell, V. L., Burgess, H. J., Gazda, C. J., Smith, M. R., Fogg, L. F., and Eastman, C. I. Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light. And O'Steen, W. K. Melatonin increases photoreceptor susceptibility to light-induced damage. Baykara, B., Tekmen, I., Pekcetin, C., Ulukus, C., Tuncel, P., Sagol, O., Ormen, M., and Ozogul, C. The protective effects of carnosine and melatonin in ischemia-reperfusion injury in the rat liver. Ortiz-Lopez, L., Morales-Mulia, S., Ramirez-Rodriguez, G., and Benitez-King, G. ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration. Forrest, C. M., Mackay, G. M., Stoy, N., Stone, T. W., and Darlington, L. G. Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin. Klupinska, G., Poplawski, T., Drzewoski, J., Harasiuk, A., Reiter, R. J., Blasiak, J., and Chojnacki, J. Therapeutic effect of melatonin in patients with functional dyspepsia. Independent third-party testing adds reassurance that the gummies contain what they claim, and nothing else. All to say, we focused on flavor, chewability, and overall ease of consumption, with higher marks given to gummies that balanced sweetness and texture without being cloying or difficult to eat. A gummy that’s overly sticky, tough, or leaves a medicinal aftertaste can be off-putting, while one with a pleasant flavor that’s easy to chew adds to the routine. When other sleep-supporting herbs — such as chamomile, passionflower, or L-theanine — were included, we favored evidence-based dosages. Nordic Naturals uses only natural ingredients, and this supplement is certified vegan and non-GMO. This combination could help improve sleep quality, promote relaxation, and reduce anxiety and insomnia6.3, 4 These gummies break down to just 52 to 56 cents per serving, depending on which size you get (ordering the larger bottle brings the cost down a bit). Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia. Dodge NN, Wilson GA. Melatonin for treatment of sleep disorders in children with developmental disabilities. Pro-convulsant effects of oral melatonin in neurologically disabled children. Shamir E, Laudon M, Barak Y, et al. Melatonin improves sleep quality of patients with chronic schizophrenia. I don’t often take melatonin, and if I do, it’s 3 milligrams or less, so 10 milligrams knocked me out,” resulting in a 3 out of 5 rating for side effects.Some reviewers say the taste isn’t great, but they work quickly and have led to much deeper, more restorative sleep.Children and adolescents should take 0.5 to 3 milligrams and 3 to 5 milligrams, respectively.1Long-term melatonin treatment in blind children and young adults with circadian sleep-wake disturbances.On a positive note, customer service impressed Cait, who rated this category a 5 out of 5.These are some melatonin gummies that almost made our main panel, but didn’t quite make the cut.It’s generally recommended to start with a low dose22 to see how it works for you, and then gradually increase your intake from there, if needed.Pediatric sleep experts generally recommend addressing the root causes of sleep issues before considering supplements. Attenburrow ME, Cowen PJ, Sharpley AL. Low dose melatonin improves sleep in healthy middle-aged subjects. A dose response study. Lissoni P, Brivio O, Brivio F, et al. Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma. Melatonin for the treatment of sleep disturbances in major depressive disorder. The absolute bioavailability of oral melatonin. Effect of melatonin on jet lag after long haul flights. James M, Tremea MO, Jones JS, Krohmer JR. Can melatonin improve adaptation to night shift? Potentiation of isoniazid activity against Mycobacterium tuberculosis by melatonin. Take the Sleep Quiz to help inform your sleep improvement journey. Melatonin supplements are also available as liquids, sprays, and patches, as well as capsules and tablets. This hormone helps regulate the body’s circadian rhythm, which controls sleepiness and wakefulness. Easily sort, filter, and compare mattress options all in one convenient view. Because research on its safety in kids is limited, organizations like the American Academy of Sleep Medicine caution against routine use. Tamura, E. K., Cecon, E., Monteiro, A. W., Silva, C. L., and Markus, R. P. Melatonin inhibits LPS-induced NO production in rat endothelial cells. Regodon, S., Ramos, A., Morgado, S., Tarazona, R., Martin-Palomino, P., Rosado, J. A., and Miguez, Mdel P. Melatonin enhances the immune response to vaccination against A1 and C strains of Dichelobacter nodosus. Esposito, E., Genovese, T., Caminiti, R., Bramanti, P., Meli, R., and Cuzzocrea, S. Melatonin reduces stress-activated/mitogen-activated protein kinases in spinal cord injury. Rimmele, U., Spillmann, M., Bartschi, C., Wolf, O. T., Weber, C. S., Ehlert, U., and Wirtz, P. H. Melatonin improves memory acquisition under stress independent of stress hormone release. You can try the gummies for up to two months and return them for a refund if you don’t like them. Because of this, it’s safe to say that the company knows a thing or two about effective ingredients. Natural Vitality, which has been around since the 1980s, has a whole supplement line that’s designed to help calm you down and support sleep. Medications changed by the liver (Cytochrome P450 3A4 (CYP3A substrates) interacts with Melatonin Fischer, S., Smolnik, R., Herms, M., Born, J., and Fehm, H. L. Melatonin acutely improves the neuroendocrine architecture of sleep in blind individuals. Sandyk, R. Melatonin and maturation of REM sleep. Ray, C. A. Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans. Koyama, H., Nakade, O., Takada, Y., Kaku, T., and Lau, K. H. Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activation. Pei, Z., Pang, S. F., and Cheung, R. T. Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. Johnson, K., Page, A., Williams, H., Wassemer, E., and Whitehouse, W. The use of melatonin as an alternative to sedation in uncooperative children undergoing an MRI examination. Lewy, A. J., Emens, J. S., Sack, R. L., Hasler, B. P., and Bernert, R. A. Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period. Pei, Z., Ho, H. T., and Cheung, R. T. Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat. For example, vitamin B6 has been shown to boost the production of melatonin, while L-theanine can help reduce stress and anxiety, making it easier to fall asleep.2, 4Melatonin gummies are just one form of melatonin supplement marketed to help people with sleep troubles.With 10 mg of melatonin per serving, these vegan gummies are ideal for older adults who face poor sleep quality as a result of decreasing melatonin production levels.Knowing the best melatonin gummies for your sleep needs can be rather confusing which is why we are compiling a list of 5 best melatonin gummies for good sleep in 2025.For melatonin gummies, that means around 1 to 5 milligrams of melatonin for most adults.Luchetti, F., Betti, M., Canonico, B., Arcangeletti, M., Ferri, P., Galli, F., and Papa, S. ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells.Natrol Kids Melatonin Gummies provides a gentle, non-habit-forming sleep aid designed specifically for children. Jan JE, O'Donnell ME. Use of melatonin in the treatment of paediatric sleep disorders. Effect of melatonin in selected populations of sleep-disturbed patients. Lissoni P, Tancini G, Barni S, et al. The pineal hormone melatonin in hematology and its potential efficacy in the treatment of thrombocytopenia. Garfinkel D, Laudon M, Nof D, Zisapel N.Improvement of sleep quality in elderly people by controlled-release melatonin. They’re ideal for light sleepers, those new to melatonin, or individuals who need minimal assistance in falling asleep. Nature’s Truth Low Dose Melatonin Gummies are a sleep supplement for those who prefer a milder melatonin option. Natrol Kids Melatonin Gummies provides a gentle, non-habit-forming sleep aid designed specifically for children. Nature’s Truth Melatonin Gummies offer a plant-based, vegan-friendly sleep aid to support your body’s natural sleep cycle. However, it’s also worth noting that each gummy contains 5 mg of melatonin, which may be a little too much for some users. Zarbee’s Children’s Sleep and Immune Gummies She is also currently taking a sleep science certification course.However, melatonin gummies may not lead to better sleep quality for everyone.Huang, J. Y., Hong, Y. T., and Chuang, J. I. Fibroblast growth factor 9 prevents MPP+-induced death of dopaminergic neurons and is involved in melatonin neuroprotection in vivo and in vitro.Green, A., et al. “Evening light exposure to computer screens disrupts human sleep, biological rhythms, and attention abilities”.Third-party testing is limited, though the gummies are manufactured in FDA-, NSF-, and GMP-compliant labs.“Each gummy only has 1 milligram of melatonin, which is my preferred low dose because it doesn’t hit me like a train and leave me with psychedelic dreams and morning confusion,” she said, giving the gummies a 5 out of 5 for side effects.Some customers say they don’t like the taste and texture, but others say they work great and the benefits of having no sugar outweigh any of the cons.Melatonin gummies are available in a wide range of dosages, and the right one for you depends on why you’re taking melatonin and how your body processes it. Long-term melatonin treatment in blind children and young adults with circadian sleep-wake disturbances. Bregani ER, Lissoni P, Rossini F, et al. Prevention of interleukin-2-induced thrombocytopenia during the immunotherapy of cancer by a concomitant administration of the pineal hormone melatonin. Lissoni P, Barni S, Ardizzoia A, et al. A randomized study with the pineal hormone melatonin versus supportive care alone in patients with brain metastases due to solid neoplasms. Lissoni P, Barni S, Cattaneo G, et al. Clinical results with the pineal hormone melatonin in advanced cancer resistant to standard antitumor therapies. Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). We monitored for common side effects of melatonin — such as morning drowsiness, vivid dreams, or stomach upset — all of which tended to depend on the dose, although individual responses can vary. Because melatonin gummies are chewed rather than swallowed whole like sleeping pills, both taste and texture play a big role in how enjoyable they are to take. Nature Made Melatonin Gummy Maximum Strength formula delivers 10 milligrams per two-gummy serving and is USP-verified for quality. I don’t often take melatonin, and if I do, it’s 3 milligrams or less, so 10 milligrams knocked me out,” resulting in a 3 out of 5 rating for side effects. Ultimately, Olly is a strong choice for those seeking a gentler dose with extra relaxation ingredients. The better melatonin gummy depends on your goals, budget, and personal preferences. Because research on how melatonin affects fetal development is limited, pregnant women should avoid self-prescribing. As you prepare to sleep, melatonin helps maintain suitable conditions for the body to fall asleep. The gummies are easy to consume, making them the greatest option as sleeping aids. Melatonin gummies can help treat insomnia and maintain the sleep-wake cycle. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Luboshitzky, R., Levi, M., Shen-Orr, Z., Blumenfeld, Z., Herer, P., and Lavie, P. Long-term melatonin administration does not alter pituitary-gonadal hormone secretion in normal men. Shah, J., Langmuir, V., and Gupta, S. K. Feasibility and functionality of OROS melatonin in healthy subjects. And Elmer, G. W. Update on natural product--drug interactions. Babkoff, H., French, J., Whitmore, J., and Sutherlin, R. Single-dose bright light and/or caffeine effect on nocturnal performance. Peuhkuri K, Sihvola N, Korpela R. Dietary factors and fluctuating levels of melatonin. Burgess HJ, Sletten T, Savic N, et al. Effects of bright light and melatonin on sleep propensity, temperature, and cardiac activity at night. The modulation of oestrogen receptor-alpha activity by melatonin in MCF-7 human breast cancer cells. Melatonin effect on seizures in children with severe neurologic deficit disorders. Nishiyama K, Yasue H, Moriyama Y, et al. Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men. Sleep laboratory investigations on hypnotic properties of melatonin. Review of strategies for treating sleep problems in persons with severe or profound mental retardation or multiple handicaps. Pharmacokinetics of melatonin in human sexual maturation. Bertino JS, Demuro RL, Blask DE, et al. Absolute bioavailability (F) of oral melatonin (M). They are best at helping kids who are unable to sleep for reasons such as bedtime anxiety, or sleep schedule changes. This is so that they get the optimal rest that they need and won’t feel morning grogginess. It also comes with a natural mixed berry flavor for those who dislike taking or swallowing pills. As a registered dietitian, I evaluated several gummy formulations and looked at clean ingredients, effective melatonin doses, added sugars, and other research-backed nutrients and botanicals that support sleep. Many gummy supplements are sub-par, but Olly Sleep has high-quality ingredients and an effective dose of melatonin without too much added sugar. With 10 mg of melatonin per serving, these vegan gummies are ideal for older adults who face poor sleep quality as a result of decreasing melatonin production levels. Efficacy of the concomitant administration of the pineal hormone melatonin in cancer immunotherapy with low-dose IL-2 in patients with advanced solid tumors who had progressed on Il-2 alone. Another reason these gummies stand out is that they’re made with pectin instead of gelatin. Melatonin is a hormone that helps regulate your sleep-wake cycle. Here at Sleep Advisor, our Sleep Certified experts use a refined mattress and product testing process to give you unbiased product suggestions… Read our full product review process. Kumar AM, Tims F, Cruess DG, et al. Music therapy increases serum melatonin levels in patients with Alzheimer's disease.However, ongoing concerns based on animal studies show melatonin can influence puberty-related hormones.A gummy that’s overly sticky, tough, or leaves a medicinal aftertaste can be off-putting, while one with a pleasant flavor that’s easy to chew adds to the routine.Entrainment of free-running circadian rhythms by melatonin in blind people.Our team has reviewed hundreds of sleep accessories and supplements, and helped nearly 132,000 shoppers find their new favorite product.Is the company well-known with a good track record of making high-quality products?They have an effective melatonin dose, other highly effective active ingredients, and a natural ingredient list. Your doctor can suggest how much melatonin is safe to take after considering your health history and the medications you currently take. There is currently no data about the long-term consequences of using melatonin. UpToDate delivers evidence-based clinical decision support that is clear, actionable, and rich with real-world insights.View Source . In general, supplements are herbs, vitamins, and other substances that people take to improve their health. Melatonin can help, but it’s best to find the source of your sleep issues. Lissoni P, Tancini G, Barni S, et al. The pineal hormone melatonin in hematology and its potential efficacy in the treatment of thrombocytopenia.Huang, L. T., Tiao, M. M., Tain, Y. L., Chen, C. C., and Hsieh, C. S. Melatonin ameliorates bile duct ligation-induced systemic oxidative stress and spatial memory deficits in developing rats.Customers say they help them fall asleep faster, but some reviewers report they wake up three or four hours into the night.Nishiyama K, Yasue H, Moriyama Y, et al. Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men.Risk of breast cancer among Norwegian women with visual impairment.These affordable high-dose melatonin gummies are vegetarian and third-party tested.You want to save some money but not at the expense of quality. Each gummy delivers a potent 10 milligrams of melatonin, making them ideal for users who need strong sleep support without a big hit to the wallet. If you or someone in your household wants to adjust the dose, Future Kind Vegan Melatonin Sleep Gummies provide 5 milligrams of melatonin for two gummies or 2.5 milligrams for one. Alongside the 5 milligrams of melatonin, each gummy provides 10 calories and just 1 gram of added sugar — a lower amount than many competitors. For adults who find 1 to 3 milligrams insufficient, this candy-like option may help, though sleep expert Dr. Shelby Harris notes, “Anything more than 3 milligrams of melatonin is considered a hefty dose. Effect of moxonidine monotherapy and in combination with melatonin on hemodynamic parameters in patients with arterial hypertension. Effects of melatonin alone and in combination with aceten on chronostructure of diurnal hemodynamic rhythms in patients with hypertension stage II. Jan, J. E., Connolly, M. B., Hamilton, D., Freeman, R. D., and Laudon, M. Melatonin treatment of non-epileptic myoclonus in children. Yeleswaram, K., Vachharajani, N., and Santone, K. Involvement of cytochrome P-450 isozymes in melatonin metabolism and clinical implications. Our tester, Cait Giddings, notes, “It’s a gummy for kids who probably otherwise wouldn’t want to take something, so it’s packaged as more of a candy than medicine,” giving the formulation a 1 out of 5. The Pure Zzzs formula also includes chamomile and lavender for added calming support, though it contains 5 grams of added sugar, food dyes, and common allergens such as soy and coconut. “That being said, we just don’t have research on its use routinely in the general child population. Just note that you should consult a pediatrician before giving your child a supplement like melatonin. Third-party testing is limited, though the gummies are manufactured in FDA-, NSF-, and GMP-compliant labs. Possibly Effective for In our tester Cait Giddings’ experience, one gummy helped her fall asleep within five minutes. Natrol Melatonin earns our top spot as the best 5-milligram gummy thanks to a potent yet approachable dose. If you are considering using melatonin with your child, always discuss this with your doctor first as there might be another effective solution that doesn’t require the use of medications or supplements.” The low dose makes it easy to start small — sometimes with just one gummy instead of two. Luthringer R, Muzet M, Zisapel N, Staner L. The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia. And Srivastava, R. S. Fluoride-induced oxidative stress in rat's brain and its amelioration by buffalo (Bubalus bubalis) pineal proteins and melatonin. Hancock, E., O'Callaghan, F., English, J., and Osborne, J. P. Melatonin excretion in normal children and in tuberous sclerosis complex with sleep disorder responsive to melatonin. A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction. Nagtegaal JE, Laurant MW, Kerkhof GA, et al. Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome. However, ongoing concerns based on animal studies show melatonin can influence puberty-related hormones. Melatonin should not be combined with other herbal or health supplements. If you are traveling through multiple time zones, this product may disrupt your sleep-wake pattern for several days. After taking the gummies, do not drive or operate machinery for at least four to five hours. Going to bed during this time will increase the chances of having a good sleep-wake cycle. Melatonin should not be used as a standalone solution for kids; instead, it should be combined with cognitive-behavioral therapy and improvements in sleep hygiene.Gupta, Y. K., Chaudhary, G., and Sinha, K. Enhanced protection by melatonin and meloxicam combination in a middle cerebral artery occlusion model of acute ischemic stroke in rat.The gummies undergo independent testing through NSF International, while still offering a strong value at just $0.11 per serving.All rights reserved.Here at Sleep Advisor, our Sleep Certified experts use a refined mattress and product testing process to give you unbiased product suggestions… Read our full product review process.While an affordable option for many, it’s important to note that not everyone will have the same experience with such a high dose.Meeking DR, Wallace JD, Cuneo RC, et al. Exercise-induced GH secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects. Are melatonin gummies safe in children? Luboshitzky, R., Shen-Orr, Z., Nave, R., Lavi, S., and Lavie, P. Melatonin administration alters semen quality in healthy men. Koc, M., Buyukokuroglu, M. E., and Taysi, S. The effect of melatonin on peripheral blood cells during total body irradiation in rats. Celebi, S., Dilsiz, N., Yilmaz, T., and Kukner, A. S. Effects of melatonin, vitamin E and octreotide on lipid peroxidation during ischemia-reperfusion in the guinea pig retina. Bilici, D., Suleyman, H., Banoglu, Z. N., Kiziltunc, A., Avci, B., Ciftcioglu, A., and Bilici, S. Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect. And with only 2 grams of added sugar per two-gummy serving, these are lighter than many competitors, earning a 5 out of 5 in this category. Olly Sleep Blackberry Zen takes the top spot as the best melatonin gummy overall, thanks to its unique yet research-backed formula and strong brand reputation. That’s when you might start searching for the best melatonin supplements and realize you prefer a gummy. These are some melatonin gummies that almost made our main panel, but didn’t quite make the cut. “I didn’t experience any grogginess when I woke up this morning, but I’m also pretty used to melatonin because I take it nightly to prevent sleepwalking.” She rated side effects a perfect 5 out of 5. Child-friendly gummies containing 0.5 mg of melatonin and calming botanicals for easy sleep. This low-dose melatonin gummy is perfect for those who only want or need a little help, and also for those who have more difficulty waking up after using melatonin. Cait reported, “I fell asleep within 15 minutes of a half-dose, slept through the night, and woke up without grogginess,” leading to a perfect 5 out of 5 for side effects. Each two-gummy serving provides 3 milligrams of melatonin, along with sleep-supporting and calming botanicals like L-theanine1, chamomile2, passionflower3, and lemon balm4. The melatonin gummies we recommend range from about 52 cents per serving to 75 cents per serving, which you can generally expect to spend on high-quality melatonin gummies. Yes, based on research13, melatonin gummies are generally considered safe for most healthy adults, even in higher doses. They also contain 5 milligrams of melatonin per two-gummy serving, which is on the high end of the effective dose range1 for adults. According to a study, the number of children who have overdosed on melatonin has increased by more than 530% in the last decade . In addition to these active ingredients, this gummy contains glucose syrup, beet sugar, water, gelatin, natural flavors, citric acid, natural coloring, pectin, vegetable oil, and carnauba wax. Plus, the best melatonin gummies typically contain effective doses of the hormone, making them just as effective as other forms. Melatonin supplements are available in many forms, but melatonin gummies are a popular pick because they often taste good and are easier to take. While we naturally produce this hormone, some people may choose to use melatonin supplements to help facilitate sleep better if they’re struggling to doze off. Choosing melatonin gummies isn’t just about grabbing the first bottle you see — things like dosage, formulation, flavor, and quality testing all play a role in finding the right fit for your sleep routine. Melatonin supplements mimic the hormone’s natural response, helping people regulate their circadian rhythm and improve sleep quality, whether they’re night-shift workers, frequent travelers, or struggle with insomnia. Also since one serving is a full gummy, splitting it to reduce the melatonin dose limits the other beneficial ingredients. Effectiveness Brzezinski, A., Fibich, T., Cohen, M., Schenker, J. G., and Laufer, N. Effects of melatonin on progesterone production by human granulosa lutein cells in culture. Nakagawa, H., Sack, R. L., and Lewy, A. J. Sleep propensity free-runs with the temperature, melatonin and cortisol rhythms in a totally blind person. Melatonin and zopiclone as facilitators of early circadian sleep in operational air transport crews. Paul, M. A., Gray, G., Kenny, G., and Pigeau, R. A. Impact of melatonin, zaleplon, zopiclone, and temazepam on psychomotor performance. Hartter, S., Nordmark, A., Rose, D. M., Bertilsson, L., Tybring, G., and Laine, K. Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity. Melatonin gummies are available in a wide range of dosages, and the right one for you depends on why you’re taking melatonin and how your body processes it. Daily use is okay in the short term, but Johns Hopkins Medicine21 recommends only taking melatonin regularly for one to two months and then seeing how your sleep is. There’s some research14 showing that melatonin can interfere with the effectiveness of some blood pressure-lowering medications. The most well-known benefit of melatonin is improved sleep. The full serving costs about $0.63, but Cait noted that she usually took half a serving (one gummy), which made the price feel more reasonable and also allowed for a smaller 2.5-milligram dose. At about $0.66 per serving, Olly scores 3.5 out of 5 for price, with added value in the brand’s reliability and the option to stretch your dollar with just one gummy. Even on nights when sleep didn’t come easily, she woke up refreshed rather than groggy, rating side effects a 5 out of 5. Our tester, Kenny Timper, found them effective for quickly getting into sleep, saying, “I took these every night for a month and they knocked me out pretty fast. If 1 milligram isn’t enough for your needs, Olly offers a 3-milligram option with botanicals for added sleep support. She notes, “They have that soft, pectin consistency that really elevates a gummy to Albanese-tier.” #IYKYK Wright KP Jr, Myers BL, Plenzler SC, et al. Acute effects of bright light and caffeine on nighttime melatonin and temperature levels in women taking and not taking oral contraceptives. Age-related decreases in melatonin secretion--clinical consequences. Patients with intractable epilepsy have low melatonin, which increases following seizures. Kumar AM, Tims F, Cruess DG, et al. Music therapy increases serum melatonin levels in patients with Alzheimer's disease. Park, J. W., Hwang, M. S., Suh, S. I., and Baek, W. K. Melatonin down-regulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells. Ozdemir, F., Deniz, O., Kaynar, K., Arslan, M., Kavgaci, H., Yildiz, B., and Aydin, F. The effects of melatonin on human hepatoma (Hep G2) cell line. And Joshi, B. N. Melatonin-induced changes in ovarian function in the freshwater fish Channa punctatus (Bloch) held in long days and continuous light. Bekyarova, G., Galunska, B., Ivanova, D., and Yankova, T. Effect of melatonin on burn-induced gastric mucosal injury in rats. Hartter S, Grozinger M, Weigmann H, et al. Increased bioavailability of oral melatonin after fluvoxamine coadministration. Dreher F, Denig N, Gabard B, et al. Effect of topical antioxidants on UV-induced erythema formation when administered after exposure. Melatonin treatment attenuates symptoms of acute nicotine withdrawal in humans. Ebadi M, Govitrapong P, Phansuwan-Pujito P, et al. Pineal opioid receptors and analgesic action of melatonin. The effect of age and pre-light melatonin concentration on the melatonin sensitivity to dim light. Does the company respond in a timely manner? You can learn a lot about a supplement, and the company that manufactures it, by reading through unbiased, firsthand reviews. If you do, you risk sacrificing quality and verification through third-party testing. Do they provide information about where their raw materials come from and where supplements are made? Risk of breast cancer among Norwegian women with visual impairment. Entrainment of free-running circadian rhythms by melatonin in blind people. Grozinger M, Hartter S, Wang X, et al. Fluvoxamine strongly inhibits melatonin metabolism in a patient with low-amplitude melatonin profile. Fluvoxamine but not citalopram increases serum melatonin in healthy subjects – an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin. Lissoni P, Barni S, Mandala M, et al. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solic tumor patients with poor clinical status.Jan, J. E., Hamilton, D., Seward, N., Fast, D. K., Freeman, R. D., and Laudon, M. Clinical trials of controlled-release melatonin in children with sleep- wake cycle disorders.Choosing the right product with the right dosage can help you fall asleep faster and wake up refreshed.It reduces core temperature, blood pressure, and stress in the body.Instead, melatonin supplements, including melatonin gummies, may help with specific sleep problems.Melatonin gummies can help treat insomnia and maintain the sleep-wake cycle.Konturek, S. J., Konturek, P. C., Brzozowski, T., and Bubenik, G. A. Role of melatonin in upper gastrointestinal tract.Melatonin gummies can be helpful for better sleep, but their cost shouldn’t leave you tossing and turning at night. Gitto, E., Karbownik, M., Reiter, R. J., Tan, D. X., Cuzzocrea, S., Chiurazzi, P., Cordaro, S., Corona, G., Trimarchi, G., and Barberi, I. Effects of melatonin treatment in septic newborns. Sharkey, K. M., Fogg, L. F., and Eastman, C. I. Effects of melatonin administration on daytime sleep after simulated night shift work. Granzotto, M., Rapozzi, V., Decorti, G., and Giraldi, T. Effects of melatonin on doxorubicin cytotoxicity in sensitive and pleiotropically resistant tumor cells. Harris, A. S., Burgess, H. J., and Dawson, D. The effects of day-time exogenous melatonin administration on cardiac autonomic activity. Cavallo, A., Ris, M. D., Succop, P., and Jaskiewicz, J. Melatonin treatment of pediatric residents for adaptation to night shift work. Hancock, E., O'Callaghan, F., and Osborne, J. P. Effect of melatonin dosage on sleep disorder in tuberous sclerosis complex. Leger, D., Laudon, M., and Zisapel, N. Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy. Sletten, T., Burgess, H., Savic, N., Gilbert, S., and Dawson, D. The effects of bright light and nighttime melatonin administration on cardiac activity. And de Launoit, Y. Is melatonin really an in vitro inhibitor of human breast cancer cell proliferation? Sjoblom, M., Jedstedt, G., and Flemstrom, G. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. Mechanisms for the protective actions of melatonin in the central nervous system. Kim, B. C., Shon, B. S., Ryoo, Y. W., Kim, S. P., and Lee, K. S. Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts. Gupta, Y. K., Chaudhary, G., and Sinha, K. Enhanced protection by melatonin and meloxicam combination in a middle cerebral artery occlusion model of acute ischemic stroke in rat. Role of melatonin in spatial learning and memory in rats and its mechanism. Awney, H. A., Attih, A. M., Habib, S. L., and Mostafa, M. H. Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1). Wirz-Justice, A., Werth, E., Renz, C., Muller, S., and Krauchi, K. No evidence for a phase delay in human circadian rhythms after a single morning melatonin administration. Wakatsuki, A., Okatani, Y., Ikenoue, N., Shinohara, K., Watanabe, K., and Fukaya, T. Melatonin protects against oxidized low-density lipoprotein-induced inhibition of nitric oxide production in human umbilical artery. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. Bjorvatn, B., Stangenes, K., Oyane, N., Forberg, K., Lowden, A., Holsten, F., and Akerstedt, T. Randomized placebo-controlled field study of the effects of bright light and melatonin in adaptation to night work. Ibrahim, M. G., Bellomo, R., Hart, G. K., Norman, T. R., Goldsmith, D., Bates, S., and Egi, M. A double-blind placebo-controlled randomised pilot study of nocturnal melatonin in tracheostomised patients. And Fairweather, K. The effect of melatonin on sedation of children undergoing magnetic resonance imaging. Acil, M., Basgul, E., Celiker, V., Karagoz, A. H., Demir, B., and Aypar, U. Perioperative effects of melatonin and midazolam premedication on sedation, orientation, anxiety scores and psychomotor performance. Since these gummies are sweetened with glucose syrup and beet sugar, they have 2 grams of added sugar per serving. All of Natural Vitality’s supplements are made with natural ingredients. In addition to this transparency, one thing that really makes these melatonin gummies stand out is the taste. In this guide, we’ll share the best melatonin gummies available right now, along with a comprehensive buying guide on how to choose the best one for you. Cait shared, “These gummies don’t have that super-soft pectin consistency — they’re a bit chewier than that — but they’re not tough or hard to break down. Our tester, Cait Giddings, gave them a 4 out of 5 for taste, saying, “I wouldn’t say these gummies taste like candy, but they’re pretty good and the blueberry flavor comes through. Plus, Livvi, a self-described insomniac, reported falling asleep quickly after taking them on more than one occasion. After all, a gummy that’s hard to chew or makes your nose scrunch up isn’t one you’ll actually want in your medicine cabinet. Marelli, M. M., Limonta, P., Maggi, R., Motta, M., and Moretti, R. M. Growth-inhibitory activity of melatonin on human androgen-independent DU 145 prostate cancer cells. Cagnacci, A., Arangino, S., Angiolucci, M., Melis, G. B., Tarquini, R., Renzi, A., and Volpe, A. Different circulatory response to melatonin in postmenopausal women without and with hormone replacement therapy. Shamir, E., Barak, Y., Plopsky, I., Zisapel, N., Elizur, A., and Weizman, A. Is melatonin treatment effective for tardive dyskinesia? While some extra-strength melatonin gummies have 10 milligrams per serving, 1 to 5 milligrams is enough for most adults.1 Targeting this range should make side effects less likely. Some melatonin gummies offer as much as 10 milligrams of melatonin per serving, but a higher dose doesn’t necessarily mean it’s more effective. Many melatonin gummies can have sub-par ingredients and too much sugar, but the Mary Ruth Melatonin Sleep Gummies stand out because they’re sugar-free and contain only natural ingredients. Made with clean, non-GMO ingredients, these gummies are a great choice for those seeking a natural, low-dose sleep supplement. With just 1mg of melatonin per serving, these gummies support a natural sleep cycle without the risk of morning grogginess. For most adults, typical dosages range from 1 to 3 milligrams, though some may need more or less. Both are NSF certified, so quality and safety are backed by third-party testing. Instead, it’s best to work with a healthcare provider to find safe, effective strategies for improving sleep. But taste, chew, and real-world effects matter just as much, so I leaned on Sleepopolis’s team of testers for firsthand feedback on side effects, texture, and flavor. We’ve all had those restless nights — tossing and turning, anxiously watching the minutes tick toward your alarm. Her other interests (besides napping and writing) include digital art, history, and boba tea. Jang, S. S., Kim, W. D., and Park, W. Y. Melatonin exerts differential actions on X-ray radiation-induced apoptosis in normal mice splenocytes and Jurkat leukemia cells. Velarde, E., Alonso-Gomez, A. L., Azpeleta, C., Isorna, E., and Delgado, M. J. Melatonin attenuates the acetylcholine-induced contraction in isolated intestine of a teleost fish. Cetin, Y., Sagcan, S., Gungor, O., Ozyurtlu, N., and Uslu, B. A. Effects of CIDR-G and melatonin implants, and their combination on the efficacy of oestrus induction and fertility of Kilis goats. To find the best melatonin gummies, I combined my expertise as a registered dietitian with insights from sleep experts and first-hand testers following our review methodology. Whether you’re a shift worker, international traveler, or just someone who wants a better night’s rest, this guide will help you find the best melatonin gummies for you. Research shows that supplements that contain between 1 and 5 milligrams of melatonin per serving are most effective for adults.1 A dose of 10 milligrams of melatonin per day is likely safe, but you don’t necessarily need that much. Melatonin gummies are considered safe for short-term use, but they can cause side effects, especially in higher doses28. For example, vitamin B6 has been shown to boost the production of melatonin, while L-theanine can help reduce stress and anxiety, making it easier to fall asleep.2, 4 This action of melatonin starts two to three hours before bedtime, and it is called dim light melatonin onset (DLMO). It reduces core temperature, blood pressure, and stress in the body. Approximately 50 to 70 million adults in the United States or one in every three people suffer from a sleep disorder, which includes insomnia or sleep deprivation. WebMD does not provide medical advice, diagnosis or treatment. Koc, M., Taysi, S., Emin, Buyukokuroglu M., and Bakan, N. The effect of melatonin against oxidative damage during total-body irradiation in rats. Effect of melatonin on lymphocyte proliferation and production of interleukin-2 (IL-2) and interleukin-1 beta (IL-1 beta) in mice splenocytes. Chen, Z., Chua, C. C., Gao, J., Hamdy, R. C., and Chua, B. H. Protective effect of melatonin on myocardial infarction. Sener, G., Tosun, O., Sehirli, A. O., Kacmaz, A., Arbak, S., Ersoy, Y., and Ayanoglu-Dulger, G. Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion.