Cannabinoids and Tremor Induced by Motor-related Disorders: Friend or Foe?

This system plays a crucial role in regulating motor control, inflammation, and anxiety, all of which are relevant to essential tremor. Current treatment options for essential tremor include medications, surgery, and lifestyle changes, but these often have limitations and may not provide adequate relief for everyone. The symptoms of essential tremor can vary in severity and impact daily life, making everyday activities such as eating, writing, and dressing challenging. Hand tremors, also known as shaky hands, are a common symptom of essential tremor, a neurological disorder that affects millions of people worldwide. But based on what we know, CBD doesn’t cause muscle spasms, and in fact, it may help address the discomfort that comes with them. More research on how CBD affects the muscles is needed before we fully understand its benefits for muscle relaxation — or if there are any drawbacks. Broad-spectrum and isolate extracts are THC-free, which rules out the possibility of cannabinoid-induced spasms. Since starting CBD treatment, James noticed a marked reduction in his tremors and improved motor control. James, a 61-year-old man, experienced significant relief from his essential tremor symptoms by incorporating CBD into his daily routine. Anne, a 54-year-old woman living with essential tremor for over a decade, had struggled to find effective treatments. By following these tips and considerations, individuals with essential tremor can make informed decisions about using CBD oil for hand tremors and managing their condition. Prior to incorporating CBD into your routine, it’s important to consult with a healthcare professional who specializes in essential tremor or neurological disorders. Through these pathways, CBD can ease symptoms of tremors on top of effectively acting as a neuroprotectant. The mechanism behind the potential positive effect of CBD on tremors isn’t well-known yet. More often than not, tremors are caused by neurological disorders in the brain regions that control movement. CBD's potential effect on these cells might influence its efficacy in treating tremors and other neurological issues. Both have been explored for their potential benefits in treating hand tremors, with each offering unique advantages. Its potential neuroprotective and anti-inflammatory properties have been researched for various conditions, including tremors. The increasing popularity of CBD oil as a potential remedy for tremors has many people considering its use. Besides CBD and THC, full-spectrum CBD oil contains terpenes, flavonoids, and other beneficial cannabinoids, offering a comprehensive therapeutic experience. In this study the additional constraints included the expiration of IMP (twice), complexity of US/Canadian regulatory approvals for import/export of new IMP during the COVID-19 pandemic, and resource/funding limitations. While larger trials will continue to test cannabis for various neurological indications, we also identified the need for regulatory and legal reforms to reduce the complexity and burden of conducting rigorous trials. A recent review of clinical trials using THC for other indications reported that doses comparable to those used in our study improved pain and social stress . A review of CBD in clinical populations suggested overall better clinical effects with higher dosing . Moreover, an early clinic report suggests no advantageous effects of cannabis on tremor among 5 unresponsive patients to anticholinergics and beta blockers . While, at present, inconclusive results have been obtained, future investigations should extend preclinical studies with different cannabinoids to controlled clinical trials to determine potential benefits in tremor. In this review, we focus on possible effects of cannabinoid-based medicines, in particular on Parkinsonian and multiple sclerosis-related tremors and the common probable molecular mechanisms. Clinical trials have suggested a beneficial effect on hand tremors and motor function in some patients. The intoxicating ingredient has been removed after initial extraction so that the user can benefit from some of the entourage effects without worrying about failing a drug test. In the entourage effect, the sum of all active ingredients in the plant is more potent therapeutically than each compound in isolation. The authors concluded that more research would help establish CBD’s clinical value on brain injury and stroke. The researchers administered 3mg/kg of CBD per day to mice models with cerebral ischemia — reporting improved motor coordination and neurological scores. Other studies implicate that CBD can have therapeutic benefits for people with anxiety disorders and neuropsychiatric conditions. In a systematic review published by Koppel et al. , oral cannabis extract and Δ9-THC was considered, at present, “probably ineffective” and Sativex (nabiximols) “possibly ineffective” for easing MS-related tremors . A plausible argument for using cannabinoid agonists as therapeutic agents has arisen from studies describing the inhibitory effect of CB1R activation on glutamate release and its capability to oppose subthalamonigral neuronal overactivity and subsequently reduce tremor 64, 76, 77. By contrast, a questionnaire-based study revealed a 30.6 % improvement in rest tremor in tremulous patients with PD . The increase in the levels of endocannabinoids and alteration in both CB1R and CB2R expression in different stages of PD opens the possibility of manipulation of receptor function in the management of disease 64, 70. PD is a progressive neurodegenerative disease affecting basal ganglia and characterized by tremor, rigidity, bradykinesia, and muscle stiffness 62–64. People with PD are already using CBD in various forms for all sorts of symptoms of PD including insomnia, anxiety, tremor, dystonia and pain. There have been a few studies of CBD for various symptoms of PD which have generally involved a small number of patients. Therefore, clinical trials become essential to support any claims that CBD should be used for medical purposes. CBD is extremely helpful in calming down the body and mind, which is why it’s so beneficial for anxiety reduction, convulsions, stress and anxiety, and of course, tremors. The current research suggests that cannabis and CBD may help reduce tremor severity and improve quality of life, but individual results may vary. Additionally, it is crucial to consult with a healthcare professional before starting any new treatment, including CBD gummies, to ensure safe and effective use. It is essential to choose a reputable manufacturer that provides high-quality CBD products, as the quality of CBD gummies can vary significantly between brands. A healthcare professional can provide personalized advice and guidance on selecting the best CBD gummies for hand tremors. However, it is essential to consult with a healthcare professional before starting any new treatment, including CBD gummies, to ensure safe and effective use. In addition to their potential therapeutic benefits, CBD gummies are also relatively safe and well-tolerated, with few reported side effects. CBD oil is made by extracting CBD from the cannabis plant and diluting it with a carrier oil, such as coconut or hemp seed oil. Involuntary shaking occurs when the motor neurons send out conflicting signals at the same time. Both voluntary and spontaneous movements are triggered when the spinal cord's motor neurons are activated. 'We discovered that an injection with the cannabinoid WIN55,212-2 into the spinal cord turns on the astrocytes in the spinal cord and prompts them to release the substance adenosine, which subsequently reduces nerve activity and thus the undesired shaking'. Cannabinoids are compounds found in cannabis and in the central nervous system. Generally speaking, dehydration and depletion of electrolytes can result in muscle spasms. If you take CBD to help manage stress or anxiety, it’s possible that the situation you’re dealing with is, itself, the cause of the muscle spasms. Stress and anxiety, if extreme enough, can cause your muscles to twitch. When selecting CBD gummies for hand tremors, there are several factors to consider, including CBD concentration, ingredient quality, and manufacturer reputation. They are also easy to incorporate into daily life, making them a convenient option for people seeking to manage their hand tremors. The exact mechanisms by which CBD oil interacts with the body to produce its effects are complex and not fully understood, but it is believed to involve the modulation of the body's endocannabinoid system. These products are not intended to diagnose, treat, cure, or prevent any disease. Tahiro's Brain Protect CBD and Omega 5 Softgels combine the benefits of CBD with the neuroprotective properties of Omega 5, providing a powerful supplement for brain health and tremor relief. A consultation with a holistic or integrative neurologist should help you find the right set of remedies and adjustments to help you cope with tremors without frustration. Several studies have already shown that it has the ability to improve primary motor symptoms of neurological conditions such as Parkinson’s Disease. There is also an animal study that supports previous findings which report that chronic, but not acute, Δ9-THC-rich extracts are effective in reducing tremor and spasticity . Following this premise, De Lago et al. have shown that the nonselective cannabinoid agonist WIN 55,212-2 ameliorated neurological disability, tremor, and spasticity in the chronic relapsing experimental autoimmune encephalomyelitis murine model of MS . Despite these conflicting results, cannabinoid-based compounds should not be neglected as a treatment strategy. It has also been suggested that cannabinoid agonists and endocannabinoids can block dopamine transporters and thereby inhibit dopamine reuptake to ameliorate dyskinesia 78–80. Endocannabinoids are produced “on demand” and act as a retrograde messenger on presynaptic cannabinoid receptors.

Conclusion: Is CBD Good for Your Muscles or Not?

It is essential to consult with a healthcare professional to determine the best course of treatment and develop an effective tremor relief plan. Uncontrollable body shakes can be a symptom of various health conditions, including essential tremor, Parkinson's disease, and anxiety disorders. CBD oil has been shown to have anti-inflammatory and anxiety-reducing properties, which may contribute to its potential benefits for essential tremor. Studies have shown CBD to have potential for a number of therapeutic effects. CBD is one of the most prevalent active cannabinoids in the cannabis plant. The symptoms of hand tremors range from non-serious to debilitating. Hand tremors are small, rhythmic, involuntary muscle contractions that cause your hands to shake or tremble. These positive results from the aforementioned studies shed new light on the therapeutic use of CBD for tremors. Next, the team worked to discover what receptors in the brain might be involved in the noted effects. In this study, Dr. Handforth aimed to show CBD can suppress tremor in animal models. Unlike the well-known cannabinoid “THC” (tetrahydrocannabinol), which has mind- and mood-altering effects, CBD does not alter the mind, the emotions, or one’s judgment. Actually, marijuana is made up of many related chemicals, called cannabinoids.” Researchers at the University of San Diego plan to administer an oral capsule containing THC and CBD to study its combined efficacy and safety in the treatment context of ETs.
  • While these user reviews and real-life examples are promising, it is essential to note that individual results may vary, and CBD gummies may not work for everyone.
  • While there's no known cure yet, there are numerous treatments available, including medications and lifestyle adjustments.
  • This includes providing resources to guide proper dosing and product selection while emphasizing the importance of using cannabis under medical supervision.
  • The enzymes create and also break down endocannabinoids when they are no longer needed.
  • When these cells send conflicting signals or become overactive, it can result in undesired shaking or tremors.
  • In reality, hemp and marijuana are two different names for the cannabis plant, with hemp defined as cannabis containing less than 0.3% THC.
  • On the other hand, CBD derived from a cannabis plant containing more than 0.3% THC is federally illegal – even if the CBD is purified and the product itself contains less than 0.3% THC.
  • Instead, it is known for its potential therapeutic properties, such as anti-inflammatory and neuroprotective effects.

Cannabinoids and HD-related Tremor

While research on the use of cannabis for essential tremor is extremely limited, we can look at the effects that cannabis has on other diseases in which tremor is prevalent such as Multiple Sclerosis (MS) and Parkinson’s disease. Its potential to reduce tremors, improve motor control, and provide a natural approach to symptom management make it a compelling option for individuals seeking relief from essential tremor. There are now several lines of evidence indicative of therapeutic potentials of cannabinoids in the control of MS-related symptoms, including tremor, which remains difficult to manage with current medications (e.g., carbamazepine, propranolol, primidone, and gluthetimide) 12, 89, 91, 92. Moreover, regulatory reforms at the federal level are critical to facilitate research and ensure patient access to high-quality, standardized cannabis products. By interacting with the ECS, cannabinoids like tetrahydrocannabinol (THC) and cannabidiol (CBD) offer a novel mechanism to address the dysregulated neural activity underlying Essential Tremor. The endocannabinoid system is a complex cell-signaling network present throughout the body, and plays a key role in regulating motor control. A double-blind randomized placebo controlled study failed to show any favorable effects of a cannabis-based medicinal extract on tremor in a subgroup of 13 patients 97, 98. Correspondingly, this study revealed the prominent role of CB1R activation in the relief of tremor and spasticity, as a selective CB1R, but not a CB2R, antagonist reversed the positive effects of preadministered cannabinoids; moreover, no beneficial effects were observed by administering a selective CB2 agonist 93, 94. CBD interacts with the body's endocannabinoid system, potentially leading to ease in symptoms of tremors.

Best Type of CBD to Use for Hand Tremors

In this article, we’ll take a look at the science to see if CBD causes muscle spasms, or if what you’re experiencing is likely due to something else. Whenever CBD and muscle spasms are discussed, it’s usually in the context of the benefits CBD has to offer if you’re dealing with them. Oral THC/CBD was tolerated by most participants, although a minority was unable to continue treatment. As the study did not reach its accrual goal of 14 completers, only tentative conclusions can be offered. Despite these challenges, our findings reported here provide multiple new key learnings to support the development of future cannabis trials for various neurological disorders. It is not just the Parkinson’s disease community that has taken an interest in CBD. There is also a very confusing array of CBD products that are available for purchase. To add to the confusion, is the fact that each state has its own laws that govern the use of CBD products which often contradict federal law. It seems that alterations to the endocannabinoid system may play a role in Parkinsonian tremor pathogenesis and that more studies are requisite to consider a further range of individual cannabinoids as potential therapeutic agents for managing signs and symptoms of PD, in particular, tremor. The emergence of CBD oil as a potential therapeutic remedy for various ailments, including tremors, has piqued the interest of the medical community and patients alike. Cannabis and CBD may offer potential therapeutic benefits for essential tremor, but more research is needed to fully understand their effects and determine their safety and efficacy.
Is It Parkinson’s or Essential Tremor?
Monitoring effects, adjusting as necessary, and prioritizing safety ensures a beneficial experience with CBD therapy. It's imperative to be aware of these possible reactions and adjust the dosage or seek medical guidance if they persist. Regular monitoring and noting the effects can help in fine-tuning the dose.
  • ARCannabisClinic takes pride in being the vanguard for comprehensive diagnostic evaluations, including PTSD, anxiety, and an array of general medical conditions.
  • The study found that CBD exerted neuroprotective actions and assisted in repairing communication between neurons in the brain.
  • From there, you can gradually adjust the amount of CBD to the point where it effectively reduces tremors.
  • The benefits of CBD oil, including its anti-inflammatory and anxiety-reducing properties, may also be relevant to essential tremor, making CBD gummies a potentially useful treatment option.
  • Several studies have already shown that it has the ability to improve primary motor symptoms of neurological conditions such as Parkinson’s Disease.
  • This is not surprising since CBD is a well-known anxiolytic, but milder treatment options without side effects are necessary because Parkinson’s tends to affect the older population.
Then, if reduced, the team had to discover how CBD suppressed the tremor. If successful, it would offer justification for further study of CBD in humans. However, CBD does not produce any intoxicating effects or alteration in mood. In this study, Dr. Handforth is looking at a specific chemical called Cannabidiol. It is well known that certain chemicals in cannabis activate specific receptors throughout the body and these chemicals may be useful in treating neurological conditions, like ET. Tremors are typically caused by problems within parts of the brain that are responsible for movement control. Remember, each individual is unique, and so too is their response to treatment. This is mainly due to the normal aging process which can lead to the degeneration of certain parts of the brain responsible for controlling movement. However, it's important to note that the effectiveness of these medications can vary greatly from person to person, and side effects may occur. They were 10 males and 9 females, had mean 63 years of age, and mean 23 years of disease duration and had insufficient control of their tremors with the usual pharmacological treatment. Additionally, many healthcare providers remain hesitant to recommend medical cannabis due to limited standardization in dosing, formulation, and long-term safety data. It is important to remember that each person is unique and has different needs with respect to their medical treatment as well as their endocannabinoid system. Although the scientific basis for using medical cannabis in Essential tremor is compelling, clinical research in this area is still in its infancy. Cannabis's effects on muscle relaxation may help reduce involuntary contractions, while neuroprotective effects may help preserve normal function and delay disease progression.
Guidance on Finding the Right CBD Dosage for Tremors
These studies aimed to understand the effects of CBD on tremor reduction and its overall impact on individuals with essential tremor. When using CBD oil for hand tremors, it is essential to choose high-quality products from reputable brands. Each individual’s experience with essential tremor and response to CBD may vary, so it’s essential to consult with a healthcare professional for personalized advice. By modulating the endocannabinoid system, CBD may help reduce tremors and improve motor control. Before CBD, his tremors caused difficulties in holding objects and affected his overall quality of life. These firsthand accounts highlight the positive impact CBD has had on their tremors and overall well-being. They can provide personalized advice, recommend suitable CBD products and dosages, and monitor your progress throughout the treatment journey. Additionally, CBD oil may help regulate the body's motor control systems, reducing the frequency and severity of tremors. Research on the effectiveness of CBD oil for essential tremor is ongoing, but preliminary studies suggest that it may help reduce tremor severity and improve quality of life. As a result, many people are seeking alternative treatments, including CBD oil and CBD gummies, to help manage their hand tremors and improve their quality of life. The central hypothesis is that CBD will reduce tremor amplitude while being well tolerated and safe. Any medical information provided is solely for the purpose of providing information and is not intended as medical advice. If you would like to try CBD for one of your PD symptoms, have a conversation with your movement disorders specialist about it. Many have been open-label trials, in which the doctor and patient are both aware that the patient is receiving treatment and there is no control group that received a placebo.
Tremor Relief for Hands, Head, Legs, and Feet
  • In addition, for individuals where medications such as beta blockers are not effective, alternative treatments including deep brain stimulation and focused ultrasound may be considered.
  • Additionally, CBD oil may help regulate the body's motor control systems, reducing the frequency and severity of tremors.
  • Yes, CBD may positively affect the muscles by promoting physical comfort and muscle recovery.
  • Despite these conflicting results, cannabinoid-based compounds should not be neglected as a treatment strategy.
  • To minimize the chances that your CBD product will cause you to experience muscle spasms, opt for a broad-spectrum or isolate CBD product.
  • Prior to incorporating CBD into your routine, it’s important to consult with a healthcare professional who specializes in essential tremor or neurological disorders.
  • The crosstalk between dopaminergic transmission and endocannabinoids signaling in the striatum nigra is also well established and there is a growing body of evidence that CB1R activation by endocannabinoid retrograde signaling has the potential to decrease glutamate release in a dopaminergic D2 receptor-dependent manner 59–61.
Navigating the complexities of neurological disorders such as Parkinson's disease necessitates understanding emerging treatments. CBD gummies may be a useful adjunctive treatment option, but they should not be used as a replacement for medical treatment. Research suggests that CBD oil may help improve mobility and reduce tremor severity in individuals with Parkinson's disease. This multidisciplinary approach aims to address the unique needs and preferences of individuals with essential tremor, optimizing their treatment outcomes. As technology and scientific knowledge advance, there is potential for the development of more advanced CBD formulations specifically tailored for essential tremor. Ongoing studies and advancements in CBD formulations aim to refine treatment options and improve outcomes for individuals with essential tremor. These success stories demonstrate the potential of CBD in managing essential tremor and provide hope for those seeking relief.
  • Tahiro's Brain Protect CBD and Omega 5 Softgels combine the benefits of CBD with the neuroprotective properties of Omega 5, providing a powerful supplement for brain health and tremor relief.
  • By consulting with a healthcare professional, individuals can ensure safe and effective use of CBD gummies for their hand tremors.
  • Many people who have reported experiencing muscle spasms after using THC found that eating bananas helped.
  • Furthermore, many clinical studies have reported psychoactive side effects of cannabinoids and hence their introduction in clinical use remains somewhat controversial.
  • A well-regarded approach within the medical community is to start with a low dosage and increase it gradually until the desired effect is achieved.
  • After looking at several options the information suggests that CBD activates the 5HT1a receptors to suppress tremor by activating the TRPV1 receptor.
  • While research on the use of cannabis for essential tremor is extremely limited, we can look at the effects that cannabis has on other diseases in which tremor is prevalent such as Multiple Sclerosis (MS) and Parkinson’s disease.

CBD Oil vs. Hemp Oil for Essential Tremors

Essential tremor is characterized by involuntary shaking or trembling of various parts of the body, including the hands, head, and voice. After looking at several options the information suggests that CBD activates the 5HT1a receptors to suppress tremor by activating the TRPV1 receptor. Testing a variety of doses, Dr. Handforth was able to note a robust suppression of tremor in the mice given CBD, without the animals showing any signs of impairment or sedation. In order to understand how CBD works for essential tremor, it is important to delve into the science behind its mechanisms of action. It is important to consult with a healthcare professional before incorporating CBD products into a tremor management routine. While CBD oil shows promise in managing hand tremors, further research is needed to fully understand its mechanisms of action and long-term effects. It’s important to note that while CBD shows promise in managing essential tremor, it may not be a cure-all solution.

Stress & anxiety

“We discovered that an injection with the cannabinoid WIN55,212-2 into the spinal cord turns on the astrocytes in the spinal cord and prompts them to release substance adenosine, which subsequently reduces nerve activity and thus the undesired shaking. However, the cannabinoid might also have a beneficial effect on sclerosis and spinal cord injuries, for example, which also cause involuntary shaking,” explains Jean-Francois Perrier, PhD. The latest study was conducted by researchers from the Department of Neuroscience at the Faculty of Health and Medical Sciences from the University of Copenhagen. While the disorder presents daily challenges, emerging research on potential treatments like CBD offers hope for improved quality of life. For those interested in exploring the potential benefits of medical marijuana for Essential Tremor and other conditions, understanding how to secure a medical marijuana card is crucial. When these cells send conflicting signals or become overactive, it can result in undesired shaking or tremors. CBD has neuroprotective properties, meaning that it helps to protect the brain against degeneration. According to a review of studies evaluating the effects of different CBD doses in clinical populations, an effective dose can range from 1 to 50 milligrams per day. If you’re looking for more pronounced and faster-acting effects, CBD oil is a better option. The effects of CBD oil are usually noticeable within minutes after administration, lasting for up to 6 hours.
  • Broad-spectrum and isolate extracts are THC-free, which rules out the possibility of cannabinoid-induced spasms.
  • The effects of CBD inhaled through aerosols or vaporization can be felt in 10 minutes or less.
  • First, the study had to determine what effects CBD would have on mice impacted with harmaline–induced tremor.
  • Although this is interesting and potentially exciting information, there are numerous other chemicals that have been studied in the laboratory with these properties that did not result in clinical benefit when tried in humans.
  • CBD oil, derived from the hemp plant, has been shown to have potential therapeutic benefits for various health conditions, including essential tremor.
  • Recent clinical trials have illuminated the effective treatment possibilities with CBD products, especially concerning motor neurons and muscle movement.
  • It is recommended to start with a low dosage and gradually increase until the desired effects are achieved.
This contributes to a lower risk of developing neurological disorders such as tremors. More studies are needed in regards to cannabinoids and dopamine regulation. CBD reacts with dopamine neurotransmitters, and this could be why CBD is effective in treating tremors. We also don’t know the side effect profile of CBD in people with PD.  At baseline, people with PD may have various non-motor symptoms that may make them more prone to side effects from CBD, including fatigue and nausea. (Three other cannabis related drug products that are not CBD, but rather synthetic THC, also have FDA approval and are used to treat loss of appetite and weight loss in patients with HIV, and severe nausea and vomiting due to chemotherapy). For this reason, we’re seeing a rise in the use of CBD for Parkinson’s disease, multiple sclerosis, and other similar disorders that can cause tremors. When medicating with cannabis for tremors, stay away from THC which is not recommended for the elderly population especially those who do not want to get high. Studies have shown that cannabis can help with different types of tremors. In our Parkinson’s study, we found that 48% of patients suffering from tremor reported a noticeable decrease in tremor activity after initiation of medical cannabis therapy. While more research is needed, anecdotal evidence and preliminary studies suggest that CBD may help reduce tremors and improve motor control in individuals with essential tremor. Scientists are actively conducting research and clinical trials to better understand the therapeutic potential of CBD for essential tremor. With proper guidance and high-quality products, CBD treatment for essential tremor shows promise in providing much-needed relief and improving overall quality of life. CBD oil has shown promise in providing relief for hand tremors and managing essential tremor symptoms. These findings may result in the development of targeted treatment with little or no side effects. They can also be caused by certain neurological disorders such as strokes, multiple sclerosis, Parkinson’s disease, or traumatic brain injury. Though there are no known causes for most kinds of tremors, some are inherited genetically. Though tremors are not life-threatening, they tend to be embarrassing and can make life difficult while basic everyday and work tasks challenging and sometimes even impossible. Those at most risk for tremors are older and middle-aged adults but it can happen to people at any age and of any gender. On the other hand, CBD derived from a cannabis plant containing more than 0.3% THC is federally illegal – even if the CBD is purified and the product itself contains less than 0.3% THC. In reality, hemp and marijuana are two different names for the cannabis plant, with hemp defined as cannabis containing less than 0.3% THC. Although this is interesting and potentially exciting information, there are numerous other chemicals that have been studied in the laboratory with these properties that did not result in clinical benefit when tried in humans. CBD is different, though if you’re younger you can feel free to experiment with products that have a combination of CBD and THC. He also notes that the THC-V was also effective in taking the edge off the THC effects. She was also able to eat, which shows how cannabis can be life-saving for many. In order to better bridge this gap, it will be important to elucidate mechanisms of cannabinoid action and use comprehensive controlled studies to determine the impact of different cannabinoid-based compounds on tremor-related diseases in both animal models and humans. These reports contrast with the clear exacerbating effects of CB1R agonists in animals and suggest that investigations with different cannabinoids in patient populations with specific ataxias are needed. It is well known that cannabinoid agonists can induce motor dysfunction in the cerebellum to give an ataxic phenotype in animals, with effects ameliorated by selective CB1R antagonists 117, 118. In 2 uncontrolled single-patient, single-dose studies, nabilone produced opposing effects, worsening the symptoms and increasing choreatic movements in one study, but improving symptoms in the other 111–113. Although a decrease in CB1R density has been found in caudate–putamen and cortical regions, there are still lack of convincing data on changes to CB1R and CB2R expression and endocannabinoid transmission in both animals and postmortem brain of patients suffering from MS 12, 101. As argued below, cannabinoids could represent a promising avenue of future research. Despite significant efforts to find an effective pharmacological intervention, as yet there is limited availability of efficient treatments to reduce tremor markedly . Following the discovery of cannabinoid receptors in rat brain in 1980, the location of these receptors was mapped in mammalian species, including humans, and were shown to be ubiquitous in hippocampus, basal ganglia, and cerebellum. However, the clinical applications of cannabis remain circumscribed, largely owing to the known psychoactive effects of Δ9-THC 23, 24. Live well with medical cannabis and see what a difference it can make. These effects were tested as a monotherapy, and in conjunction with other cannabinoids, among patients with Huntington’s disease, multiple sclerosis, and Parkinson’s Disease. Based on available studies, one cannot definitively state that a 4.2mg gummy will help mitigate the symptoms of essential tremor. CBD may work for essential tremor by interacting with the endocannabinoid system in the body. They can help you explore the potential benefits and risks of managing essential tremor with CBD, as well as assist in finding the right dosage and delivery method for your specific needs. Throughout this article, we have explored the potential benefits of CBD in managing essential tremor. In 2015, the FDA changed some of their regulations to make it easier to study CBD in clinical trials. The FDA is aware that patients are frustrated that our understanding of how best to use CBD remains minimal because of the lack of clinical trials. The FDA is aware of the health claims that are made by manufacturers about various products and issues warnings to companies who market CBD products with unsubstantiated health claims. Practically, CBD products can be obtained relatively easily at health food stores and online. This has not dimmed the enthusiasm of millions of CBD users for a wide range of medical conditions.
  • The endocannabinoid system (ECS) controls an array of essential physiological processes, including motor functions and movement.
  • Cannabidiol (CBD) is a modulator of CB1 receptor and CB1 agonists can reduce tremors in experimental models.
  • James, a 61-year-old man, experienced significant relief from his essential tremor symptoms by incorporating CBD into his daily routine.
  • Scientists have been examining the health benefits of CBD for quite some time now, with great effort being fueled into research on how CBD may affect tremors.
  • Because it was so extreme, the patient was hardly able to walk and kept getting thrown off by the tremors, unable to swallow food and even write her name.
  • Recognizing and addressing the causes of shaky hands can be a crucial part of managing essential tremors.
  • Consulting with a healthcare professional experienced in CBD use is recommended to determine the optimal dosage based on individual factors such as body weight and severity of tremors.
  • Endocannabinoids and cannabinoids bind with these receptors which signal to the ECS to trigger a response.
Even if the product you’re using doesn’t contain THC, you might still experience muscle spasms after taking CBD. Properly made full-spectrum CBD products won’t contain enough THC to cause spasms, however, poorly manufactured products may. Always purchase hemp-derived products from a trustworthy provider like Natural Ways CBD. Depending upon where you’re buying CBD oil, THC and other cannabinoid contamination might be a risk. Anxiety triggers your body’s stress response, which can result in muscle spasms. The human body naturally produces endocannabinoids, neurotransmitters that bind to cannabinoid receptors in the central nervous system (CNS). Essential tremors are a common neurological disorder characterized by involuntary and rhythmic shaking, usually affecting the hands. By enhancing relaxation and lowering inflammation, hand tremor symptoms are lessened. The scientists also noted a reduction in anxiety-related tremors during a simulated public speaking test. The research team used a dose of 300 mg CBD/day, which provided significant benefits for heart rate, blood pressure, and frequency of tremors among the subjects. Aging and neurodegenerative disorders are just two causes of tremors that CBD might help with. The motor neurons connect the spinal cord with the muscles, and each time a motor neuron sends impulses to the muscles, it leads to contraction and thus movement. Targeted treatment with no problematic side effects Previous research into medical cannabis has focussed on the nerve cells, the so-called neurons. While CBD isn’t a proven treatment for muscle spasms, early research suggests it may have anti-spasmodic properties. Since THC is a potential cause of muscle spasms, full-spectrum CBD, which contains THC, has the potential to cause spasms.
  • These firsthand accounts highlight the positive impact CBD has had on their tremors and overall well-being.
  • However, more research is needed to fully understand the effects of CBD oil on these conditions and determine its safety and efficacy.
  • CBD reacts with dopamine neurotransmitters, and this could be why CBD is effective in treating tremors.
  • In 2 uncontrolled single-patient, single-dose studies, nabilone produced opposing effects, worsening the symptoms and increasing choreatic movements in one study, but improving symptoms in the other 111–113.
  • While some patients might benefit from high doses of CBD, others might experience side effects.
  • Aging and neurodegenerative disorders are just two causes of tremors that CBD might help with.
  • So not only will CBD not cause muscle spasms, but it may be therapeutically beneficial at addressing them.
Essential tremor is distinct from the tremors that are seen in Parkinson’s disease, which typically occur at rest and have different underlying mechanisms. While essential tremor can occur at any age, it is particularly prevalent among older adults and often worsens over time. Consulting with a healthcare professional experienced in CBD use is recommended to determine the optimal dosage based on individual factors such as body weight and severity of tremors. Here, oral Δ9-THC or marijuana have been reported to improve motor coordination in some patients with MS 89, 92. Therefore, data from animal models suggest either that combinations of different cannabinoids or a broad-spectrum cannabinoid may be needed to justify the lack of positive findings in some of the mentioned studies 115, 116. It should be pointed out that none of these studies has investigated disease progression and they have all used a single cannabinoid. The loss of CB1R during the progression of HD, most specifically in the lateral pallidum, in transgenic mouse models of HD and in postmortem basal ganglia of patients who suffered from HD, represents a possible justification to investigate the use of cannabinoid agonists in HD 104–107.
  • If you would like to try CBD for one of your PD symptoms, have a conversation with your movement disorders specialist about it.
  • The effects of CBD oil are usually noticeable within minutes after administration, lasting for up to 6 hours.
  • CBD, on the other hand, is generally well-tolerated and has minimal side effects, making it a safer alternative for long-term use.
  • These tremors can also occur intermittently or during separate times after breaks, but they can also be constant or sporadic.
  • This has not dimmed the enthusiasm of millions of CBD users for a wide range of medical conditions.
  • A review of CBD in clinical populations suggested overall better clinical effects with higher dosing .
Our findings did not exclude the possibility that chronic treatment with CBD could have a symptomatic effect. There is a clear need to find new effective therapies for the treatment of ET. The primary pharmacological treatment is symptomatic, but effective medicines are somewhat limited. These qualities lend themselves to calming or resolving hand tremors. This discovery could make CBD a potential alternative to pharmaceutical drugs that are laden with side effects. The enzymes create and also break down endocannabinoids when they are no longer needed. Endocannabinoids and cannabinoids bind with these receptors which signal to the ECS to trigger a response. They are similar to endocannabinoids produced by the body, and they too affect the endocannabinoid system. For more insight into the intricacies of medical marijuana and its related treatments, consider checking out this comprehensive state-by-state guide on applying for a medical marijuana card. Moreover, CBD may interact with certain medications, so it's pivotal to discuss its use with a healthcare professional, especially if one is on other treatments. While its therapeutic properties have shown promise, it's imperative to have a comprehensive understanding of its safety profile and necessary considerations before integrating it into one's treatment regimen. Like any remedy, CBD oil comes with its potential side effects, though they are generally mild. For those looking into the therapeutic potentials of marijuana, this guide on how to get a marijuana card can offer deeper insights. Through rigorous scientific investigation, researchers hope to establish evidence-based guidelines for using CBD to effectively manage essential tremor. As the use of CBD for essential tremor continues to gain attention, researchers and scientists are exploring various future directions to further enhance its effectiveness. Real people have shared their personal success stories about managing essential tremor with CBD. To ensure the best results, it’s essential to find high-quality CBD oil specifically formulated for managing essential tremor. When considering using CBD to manage essential tremor, it’s important to keep a few key tips and considerations in mind. So although CBD won’t cause muscle spasms, THC, another cannabinoid, might create spasms and spasm-like sensations if consumed in excess. So not only will CBD not cause muscle spasms, but it may be therapeutically beneficial at addressing them. We acknowledge that it remains uncertain whether a longer treatment duration may have led to further tremor reduction. You should always talk to your personal healthcare providers for specific medical and health-related instructions and guidelines. At the very least, he/she can make sure that there are no drug interactions between CBD and anything else that you take and discuss with you any potential side effects that you need to be aware of. Another study, this time from January 2020, found that one dose of CBD was beneficial in reducing anxiety and tremors among people with Parkinson’s disease. For the study, the researchers used a mouse model to demonstrate how cannabis reduces tremors caused by neurodivergent disorders or traumas, which lead to involuntary shaking in the limbs or the head. The researchers discovered that the cannabinoids within the plant interact with the astrocyte, a star-shaped cell located in the spinal cord which reduces tremors. Recognizing and addressing the causes of shaky hands can be a crucial part of managing essential tremors. Age is a significant factor, with the incidence of essential tremors increasing with age. First, the study had to determine what effects CBD would have on mice impacted with harmaline–induced tremor. Cannabidiol (CBD) is one of at least 113 active chemicals (also known as cannabinoids) identified in cannabis. The U.S. Food and Drug Administration (FDA) has not approved cannabis as a treatment for any medical condition. “First, finding that CBD suppresses tremor in an animal model may provide justification for a clinical trial of CBD for essential tremor in humans. While a beneficial response in reducing chorea has been reported for CBD , a controlled clinical trial among 15 patients with HD showed no significant improvements in chorea severity after 6 weeks of CBD administration at an average daily dose of 700 mg/day 109, 110. Involvement of the endocannabinoid system acting at CB1R in the pathogenesis of MS have been supported by several studies 87–90. Despite findings supporting this suggestion, Meschler et al. failed to show the proficiency of the CB1R antagonist SR141716A (rimonabant) in the mitigation of symptoms in a nonhuman primate model of PD. The piecemeal loss of melanin-containing nigral neurons leads to aberrant dopaminergic transmission, with tremor emerging as a consequence of subthalamic overactivity 64–69. Owing to this abundance, the potentially greater significance of CB1Rs will be the focus of this review (Table 1). CBD’s potential in reducing different types of tremors is, without a doubt, promising. Choosing between CBD oil and capsules for tremors boils down to mapping out your needs and knowing the pros and cons of both products. In a recent study published by the Journal of Psychopharmacology, the authors found that CBD reduced anxiety and tremor amplitude among PD patients. This non-reversible disorder of the central nervous system causes people to experience impaired posture, uncontrolled muscle movements, rigid muscles, and hand tremors. Research suggests that CBD has a modulating effect on the endocannabinoid system, which may contribute to its potential efficacy in managing essential tremor. When it comes to essential tremor, CBD interacts with the body’s endocannabinoid system to help regulate tremors and improve overall symptom management. Managing essential tremor can be a lifelong journey, and various treatment options are available to help reduce symptoms and improve quality of life. Fortunately, there has been growing interest in the potential benefits of CBD oil in managing essential tremors. However, recommending alcohol as a treatment option is not viable due to the risk of developing alcoholism and other long-term negative health effects. At ACIBADEM Healthcare Group, we are committed to healthcare excellence and providing world-class healthcare services to our patients. Healthcare providers may explore integrative treatment plans that include CBD alongside conventional medications or other complementary therapies. Researchers are exploring innovative delivery systems, such as transdermal patches or controlled-release capsules, to provide sustained relief from tremors throughout the day. These studies aim to identify optimal dosages, delivery methods, and long-term effects of CBD treatment. Essential tremor is a neurological disorder affecting nearly 7 million Americans and is characterized by involuntary and rhythmic shaking, most commonly of the hands. As a leader in international healthcare, we strive to deliver the highest quality of care and meet the needs of our diverse patient population. While CBD offers a natural approach to symptom management, it is important to remember that it should not replace any prescribed medications or treatments. With the growing acceptance and use of CBD, emerging trends suggest the possibility of combining CBD with other therapies for enhanced tremor relief. Further recruitment for the study was postponed due to the COVID-19 pandemic. Note that a large number of subjects were excluded at pre-screening due to presence of a resting tremor suggestive of Parkinson’s. We have received an enormous interest in the study from prospective participants. Furthermore, these findings have the potential to open up alternative basic science lines of targeted testing and drug development with the potential to develop a novel molecule specifically designed for ET and increase excitement and funding within biotechnology companies. With respect to expected outcomes, the findings of aims 1 & 2 are expected to provide the necessary pilot data to justify, or not, the scientific need for further human trials of CBD for the treatment of ET. As mentioned earlier, tremors generally result from neurodegenerative diseases, such as Parkinson’s Disease (PD). Many of the prescription drugs that people usually take for tremors carry a risk of dangerous side effects. One study on mice showed that CBD produced superior results in tremor relief without showing any life-threatening side effects or causing impairment. CBD may help regulate abnormal electrical activity in the brain, leading to a reduction in tremors. If you are considering CBD as a treatment option, it is essential to consult with a healthcare professional who can provide personalized advice. While more studies are needed to fully understand its effectiveness, many individuals have reported positive experiences with CBD for essential tremor relief. Research has shown that CBD may help reduce tremors, improve motor control, and enhance overall quality of life. As the field of CBD research evolves, future directions hold promise for individuals living with essential tremor.
  • Aside from beta blockers, other essential tremor drugs include anti-seizure medications such as Primidone, which can be effective in mitigating tremor symptoms.
  • Numerous studies have been conducted to investigate the potential benefits of using CBD as a treatment for essential tremor.
  • Cannabinoid receptors, particularly CB1 receptors in the central nervous system, modulate neuronal excitability, which can influence tremor activity.
  • Both voluntary and spontaneous movements are triggered when the spinal cord's motor neurons are activated.
  • However, finding the right CBD dosage for tremors requires an individualized approach and consultation with a healthcare professional.
  • Following the discovery of cannabinoid receptors in rat brain in 1980, the location of these receptors was mapped in mammalian species, including humans, and were shown to be ubiquitous in hippocampus, basal ganglia, and cerebellum.
  • Moreover, CBD may interact with certain medications, so it's pivotal to discuss its use with a healthcare professional, especially if one is on other treatments.
  • These effects were tested as a monotherapy, and in conjunction with other cannabinoids, among patients with Huntington’s disease, multiple sclerosis, and Parkinson’s Disease.
Within 24 hours of consuming sublingual THC-V, she displayed almost normal speech while showing that she had been able to gain better control of her tremors. Because it was so extreme, the patient was hardly able to walk and kept getting thrown off by the tremors, unable to swallow food and even write her name. CBD has been shown to be safe and have minimal effects, making it an excellent treatment alternative. This is not surprising since CBD is a well-known anxiolytic, but milder treatment options without side effects are necessary because Parkinson’s tends to affect the older population. In probing astrocytes to understand the biological effects of cannabis, the researchers take a novel approach as earlier studies have focused primarily on neurons,” he says. These tremors can also occur intermittently or during separate times after breaks, but they can also be constant or sporadic. While not life-threatening, tremors can significantly impact a person’s quality Read More As such, it's always advisable to consult with a healthcare professional for a personalized treatment plan. In addition, for individuals where medications such as beta blockers are not effective, alternative treatments including deep brain stimulation and focused ultrasound may be considered. Lifestyle changes such as reducing caffeine intake and managing stress can often help control tremors. It is posited that by reducing the levels of glutamate, THC may help control the overactivity in the brain that leads to essential tremors. In the context of essential tremors, THC has been shown to reduce involuntary muscle contractions and spasms, a vital symptom of this condition, better than CBD alone. If both CBD oil and hemp oil could potentially help with essential tremors, how can you decide between them? While there's no known cure yet, there are numerous treatments available, including medications and lifestyle adjustments. At present, despite much anecdotal evidence, observations from case studies and controlled human trials remain poorly matched with those in animal models of diseases. Cannabinoids, proposed to act predominantly via CB1R and CB2R activation, have been evaluated for different medical purposes. Du2J mice are deficit in the auxiliary Ca2+ channel subunit α2δ2, and these data are consistent with this deficit leading to aberrant CB1R signaling downstream of receptor activation; it is also possible that deficits in endocannabinoid modulation of inhibitory transmission in the cerebellum contribute to the ataxic phenotype seen here. A recent randomized, double-blind, placebo-controlled, crossover study also indicated the effectiveness of nabilone in the improvement in chorea . In addition, although placebo recipients showed faster finger tapping than that of cannabis extract recipients in a randomized double-blind crossover trial amongst 14 tremulous patients, the study was unable to show any overall marked improvement on measures of objective tremor . An earlier study reported that cannabinoid agonists Δ9-THC, methanandamide, R(+)WIN 55,212-2, and JWH-133 all diminished tremor and spasticity in the experimental autoimmune encephalomyelitis model, and that aggravation of the symptoms occurred after using CB2R and, in particular, CB1R antagonists . However, there are other studies asserting no beneficial effects of cannabinoid agonists in alleviation of motor symptoms 75, 81–83. The release of pro-inflammatory proteins in some neurological disorders can exacerbate symptoms. A crucial component in understanding the benefits of CBD for Essential Tremor lies in the compound's ability to potentially dampen the nerve activity causing the undesired shaking. The human body possesses a complex system known as the endocannabinoid system, which plays a pivotal role in regulating various physiological processes including mood, appetite, pain, and cognitive functions. These nerve cells or so-called neurons play a pivotal role in regulating our muscle movements. While science has not pinned down a singular cause, it's believed to involve the communication between certain nerve cells in the brain. However, the research is preliminary and more study is needed. No research has indicated that CBD adversely affects the muscles. Yes, CBD may positively affect the muscles by promoting physical comfort and muscle recovery. Some of the best herbs to soothe muscle spasms include chamomile, peppermint, valerian root, and ginger. Here are some questions our customers frequently ask us about CBD causing muscle spasms. Whether you're seeking relief from chronic pain, anxiety, PTSD, or other qualifying conditions, we're here to provide safe and effective treatment options and recommendations tailored to your unique needs. Experience the convenience of ARCannabisClinic's online doctor visits, offering professional, compassionate, and comprehensive marijuana-based medical advice, all at your fingertips. Entrusting one's medical marijuana needs to a credible institution like ARCannabisClinic is not only prudent but imperative. ARCannabisClinic takes pride in being the vanguard for comprehensive diagnostic evaluations, including PTSD, anxiety, and an array of general medical conditions. A study published in the British Pharmacological Society mentioned that CBD could modulate neurotransmission and prompt neurogenesis (formation of new brain cells). CBD, in turn, comes with anti-tremor properties and has a good safety profile with only minor side effects when overdosed. Let’s elaborate on that mechanism using the examples of different types of tremors. In turn, this suggests that the ECS can be a therapeutic target for people looking for effective tremor management. CBD oil may have potential therapeutic benefits for Parkinson's disease and other conditions related to hand tremors. Some experts believe that CBD oil and CBD gummies may offer a promising alternative treatment option for essential tremor, while others emphasize the need for further research to fully understand their effects. The benefits of CBD oil, including its anti-inflammatory and anxiety-reducing properties, may also be relevant to essential tremor, making CBD gummies a potentially useful treatment option. CBD oil, derived from the hemp plant, has been shown to have potential therapeutic benefits for various health conditions, including essential tremor. The exact causes of essential tremor are still not fully understood, but it is believed to be related to abnormalities in the brain's motor control systems. Instead, it is known for its potential therapeutic properties, such as anti-inflammatory and neuroprotective effects. In this article, we will explore how CBD may offer relief and improve the quality of life for individuals with essential tremor. There is still a lot we do not know about cannabis, but researchers from the Department of Neuroscience at the Faculty of Health and Medical Sciences have made a new discovery that may prove vital to future research into and treatment with medical cannabis. The hypothesis has been formulated on the basis of preliminary data and through consultation with Dr. Adrian Handforth’s group actively studying cannabinoids in the Harmaline model of ET. Essential Tremor is a neurological disorder that primarily impacts the motor neurons of the body, causing involuntary shaking. Tremor relief can be achieved through various treatment options, including CBD gummies, CBD oil, and physical therapy. However, more research is needed to fully understand the effects of CBD oil on these conditions and determine its safety and efficacy. Additionally, CBD oil may have anti-inflammatory and anxiety-reducing properties, which may contribute to its potential benefits for these conditions. 'We have focussed on the disease essential tremor. The focus of this study is to collect the necessary data needed to determine whether further research is warranted to develop cannabidiol (CBD) as a viable tremor suppressant for essential tremor. People with PD are eager to find alternative methods to help their symptoms, leading many of these patients to look into whether other therapies, such as medical marijuana, also known as medical cannabis, can be useful. According to him, it was the most severe type of essential tremors that he had come across in his 39 years of work. “This is the first study that shows the anxiolytic effects of CBD in patients with PD and its ability in attenuation of the tremor amplitude in anxiogenic situations,” says the researchers. Using a mouse model, the researchers have demonstrated that a specific synthetic cannabinoid (cannabinoid WIN55,212-2) reduces essential tremor by activating the support cells of the spinal cord and brain, known as astrocytes. Despite the limitations in our sample size and homogeneous demographics of participants (all were White men), we found no evidence to support the hypothesis that cannabis reduces the amplitude of essential tremors in the wide dose range we studied (THC 5–15 mg and CBD 100–300 mg/day). Dr. Allan Frankel MD even blogs about his experience of a cannabinoid known as THC-V found to be extremely effective in helping his 70-year old patient who was struggling with essential tremors. The results, which were published in the medical journal Nature Neuroscience, revealed that cannabis was beneficial for patients suffering from pathological tremors. However, no studies have so far investigated the role of cannabinoids in essential tremor.