Researching a brand’s reputation and reading customer reviews can provide valuable insights into the effectiveness of its CBD gummies. Always prioritize gummies with certified lab testing to ensure safe and effective use. Additionally, the pleasant taste and easy format make them suitable for people who are new to CBD. They provide a consistent dosage of CBD, making it easier to track intake for consistent relief. A Sprague-Dawley rat study showed that GPR18 receptor activation via O-1602 leads to reduction of ROS levels, however inhibition of GPR18 receptor activation increases oxidative stress by increasing ROS production . However, it has been found that HU-433 exhibits greater anti-inflammatory activity with poorer CB2 receptor binding affinity (Table 2) . However, both HU-465 and HU-446 have been found to exhibit anti-inflammatory activity by inhibiting the release of IL-17 in mouse encephalitogenic T cells (TMOG) . Similarly, the (+)-8,9-dihydro-7-hydroxy-CBD derivative (HU-465), which has anti-inflammatory activity, especially at higher concentrations, binds to both CB1 and CB2 receptors, while its (−) enantiomer, (−)-8,9-dihydro-7-hydroxy-CBD (HU-446) has negligible affinity for both CB1 and CB2 receptors (Table 2). This behavior may suggest that the activation of pro-inflammatory mediators is not directly through the CB1 cannabinoid receptor . Dosage and Potency Convenience for a CBD product isn’t just about how easy it is to take. Even so, you’ll save $120 over CBDistillery for a similar product. The company’s high-potency CBD also only costs 2-3 cents per milligram and is half the cost of CBDistillery’s similarly potent full-spectrum oil (150mg vs. 167mg). We also look at things like assistance programs (which offer savings for people who might need CBD, such as veterans and people with disabilities, but can’t afford it), subscription programs, and return policies. Turmeric and omega-3 fatty acids have some of the best research backing up their anti-inflammatory and joint-health-supportive properties. You can expect to start feeling the effects of CBD gummies after approximately minutes (depending on how quickly your body digests it). For some people, who are particularly sensitive to sugar, their body may respond more negatively to the sugar content of a gummy than is worth the benefit of the CBD. For specific trouble areas, particularly the kind that’s caused by arthritis, you’ll appreciate the fast relief from topically applying a CBD cream. These gummies from Smile CBD are unique from everything else on this list for one reason — they don’t just contain CBD. This is also one of the only gummies on the market offering a completely vegan-friendly formula for its gummies. They’re one of the few CBD gummies not made from a CBD isolate. As an all-around general-purpose CBD supplement, these gummies are one of the best on the market. In addition, individuals experience pain and respond to treatment in different ways.This is particularly important when you’re considering CBD for arthritis, as you’ll find a lot of topical creams and balms advertised to relieve pain where it’s applied.This system helps regulate functions like pain perception, inflammation, and stress response.If you’re searching for a natural, simple, and effective way to ease pain, CBD gummies might be the answer.Populum Cold Therapy Hemp Rub comprises cooling ingredients that quickly penetrate your body to provide relief.Always consult a healthcare provider before starting any new supplement, including CBD.However, there is an abundance of commercial advertisements about the magical effects of CBD, and it is frequently presented as a cure-it-all potion that will treat everything including diabetes, depression, cancer, chronic pain, and even your dog’s anxiety!On the other hand, CBD induced ubiquitination of the amyloid precursor protein (APP), an indicator of cellular changes in the brain of people with Alzheimer’s disease, when evaluated in human neuroblastoma cells (SHSY5YAPP+) . Customers rave about the Aspen Green Relief gummies, mentioning they are some of the most effective full-spectrum CBD gummies they've tried. Each flavorful piece contains 50mg CBD and 2.5mg hemp-derived THC, plus various other phytocannabinoids like CBG and CBC for the ultimate entourage effect. If you're one of the more than 53 million individuals dealing with arthritis pain, you may benefit from adding CBD to your pain management plan. We encourage you to revisit these two standout products alongside the other options we’ve highlighted. To ensure you're getting a quality product, always look for gummies that have been tested by a third-party lab. Since the effects of gummies last longer than other forms of CBD, they’re especially useful for promoting restful, uninterrupted sleep. However, the effects of CBD gummies also tend to last longer, offering extended relief. Pay attention to the concentration of CBD in each gummy, as this can vary between brands and products. While CBD gummies are generally well-tolerated, they can still cause side effects in some people. Can children use CBD gummies for pain? Furthermore, we adopted the PGIC to assess the perceived effect of CBD use on participants' sleep quality and physical function. Efficacy of CBD use for their pain and arthritis symptoms was assessed by a number of different outcome variables. Given the evidence supporting CBD as a sustainable option for pain management, we believe it may be a potential alternative in treating patients with arthritis. Best CBD Gummies for Pain Relief in 2026 If you can’t just rely on CBD oil to relieve pain, consider working it into your routine for overall wellness. This bodily system plays an essential role in helping to regulate many functions throughout the body, including pain. Cannabidiol (CBD) is one of the many active compounds in cannabis from hemp plants. This topical comes from organically farmed hemp and contains no THC. This soothing cream contains 1500mg CBD and menthol to help ease even the most stubborn pain. CBD oil, CBD gummies, or capsules work well. When buying CBD, always choose companies that prioritize quality, transparency, and customer safety. Oils and tinctures tend to act fast, while gummies and capsules offer long-lasting, steady support. These farms typically focus on cultivating hemp strains rich in CBD and other beneficial compounds while maintaining low THC levels to comply with legal requirements. Reputable manufacturers source their hemp from farms that use organic, pesticide-free, and sustainable growing practices. This method uses pressurized carbon dioxide to pull cannabinoids, terpenes, and flavonoids from the plant material without leaving harmful residues. The first step in making CBD is extracting cannabinoids and other beneficial compounds from the cannabis plant. A family-run brand out of Colorado, Joy Organics offers many high-quality CBD products, including USDA-certified organic offerings. In addition to CBD, these gummies carry uplifting terpenes and high levels of minor hemp cannabinoids like CBG. Sunmed’s products are derived from organic hemp cultivated in Colorado and Oregon. These gummies contain full-spectrum hemp extract, which is considered more effective than pure CBD. Five CBD uses organic American hemp to extract CBD for its products. Broad-Spectrum CBD Gummies Stopping inflammation means blocking these chemical messengers.This interaction can also lower inflammation and thus reduce the pain that comes with it.Full-spectrum CBD contains all plant compounds including a small amount of THC.In our assessment of pain reduction after using CBD, participants were asked to rate their pain before and after using a numerical pain score (0–10).It may also be of benefit as an adjunctive analgesic treatment for the symptomatic relief of neuropathic pain in adult patients with multiple sclerosis. Available in Citrus flavor, these CBD gummies combine lemon and lime with just a hint of orange zest that won’t linger on your palate for too long. Cornbread Hemp offers strong CBD gummies in different strengths, making it beneficial for beginners and seasoned users looking for an alternative to traditional medicines. Some users dealing with IBS reported feeling better after using these gummies. Monitor Your Body’s Response Several other studies on CBD for sleep in healthy people had no clear results. Studies show mixed results for people who used low doses of CBD spray, applied under the tongue, to treat chronic pain. These products can be used in different ways. Most participants who completed the survey had tried CBD for symptomatic relief of arthritis (70%). Numerical Rating Pain Scale point reduction and percent pain reduction were evaluated among arthritis groups with nonparametric Kruskal–Wallis tests. Inclusion criteria included participants ≥18 years old and those with a prior diagnosis of arthritis as a cause of joint pain. Additionally, participants were asked to rate their arthritis pain on a 0-to-10 Numerical Rating Scale (NRS) before and after taking CBD (Cook et al., 2013). CBD gummies can be a valuable addition to a well-rounded wellness routine that includes a balanced diet, regular exercise, and stress management techniques. The gummies from Penguin CBD, Green Roads, and BATCH CBD all offer precise dosing, making it easy to adjust your intake. The apple pie flavor feels like a little dessert, and the slightly higher CBD content helps me relax and prepare for a good night's sleep. It's become my go-to for those hectic afternoons when I need to stay productive but calm. Organic CBD gummies and those made with natural ingredients can offer more health benefits as they are free from artificial additives and often use high-quality hemp extract. While many people use CBD gummies for pain relief, these tasty edibles can offer a wide range of therapeutic benefits that go beyond just managing discomfort. Full-spectrum or broad-spectrum formulas often include other cannabinoids for the entourage effect which may enhance inflammation relief and chronic pain management. Some gummies are made with pure cbd or cbd isolate which contains only CBD and no other cannabinoids or THC, ideal for those who want targeted relief without psychoactive effects. Stronger options like full-spectrum CBD can have 25mg or more per piece and may offer more pain relief for chronic pain or arthritis pain. Simply take the mg of CBD per gummy and multiply it by the number of gummies in the bottle. These products are almost always made with some form of distillation method. Most gummies are made from CBD isolate or broad-spectrum extracts, which means they contain no THC or terpenes. When compared to other methods of extraction, such as using ethanol or butane, CO2 produces safer and high-quality CBD gummies. CBD gummies with less than 0.3% THC are generally made using industrial hemp — not marijuana. Multiple studies have shown that mice without this receptor suffer from increased inflammation.The best CBD gummies for pain contain doses of at least 20 mg and offer clear evidence they’re free from contaminants."Makeup! Used to wear it every day and buy tons of it to try new products and such. Now I only wear it for special occasions. It works great — even just a little bit of makeup really pops when you hardly ever wear any." VerschwendeMeineZeitInnerbody uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles.CBD, short for cannabidiol, is a compound found in the hemp plant.At Happy Hemp, we’re committed to providing high-quality, trustworthy CBD products designed to support wellness in every area of life.While FAB CBD Delta 9 Gummies offer various wellness benefits, they are a reliable option for those battling mild pain and tense situations.Sugar-coated CBD gummies with a hint of natural terpenes flavor? CBD gummies work best as part of a comprehensive pain management approach that addresses multiple aspects of the pain experience. This approach requires understanding your pain patterns and planning accordingly, but can dramatically improve quality of life by addressing pain before it peaks. This approach acknowledges that it’s typically easier to prevent pain from escalating than to reduce it once it reaches high levels. Taking CBD gummies regularly, rather than only when pain is severe, helps prevent pain from intensifying and may reduce the overall amount of CBD needed for management. A low dose like 5mg to 10mg of cannabidiol per gummy is for those who are new or sensitive to dietary supplements. A certificate of analysis (COA) will show you what’s in each gummy. The secret is how CBD interacts with the body’s endocannabinoid system (ECS), a network of receptors that regulates pain, mood and immune response. CBD gummies have become popular because they fit into daily life. Many are now looking for easy and tasty ways to manage pain. Available in many flavors, shapes and strengths, CBD gummies are a fun and convenient way to add CBD to your daily routine. These tasty CBD edibles are chewy, flavorful treats infused with CBD extract from the hemp plant. CBD gummies have become one of the most popular ways to enjoy the benefits of CBD. If you want a clean, effective and joy-inducing CBD gummy that delivers, Aspen Green’s Bliss Gummies are the top choice. For a woman who wants to give herself a CBD baseline to manage her daily pain, this is an ideal selection. These vegan gummies will give you all the CBD and supportive nutrients without any of the THC. Though the CBD itself isn’t dangerous for your body, the CBD may also respond poorly to other medications you’re taking. The sweeteners, in particular, used in CBD gummies that make them the tasty treat you enjoy isn’t always good for you. No, generally, CBD gummies can’t hurt you – though there are some exceptions and notes you’ll still need to consider. With the right guidance, spectrum CBD gummies can be a valuable tool to manage pain and improve your quality of life. CBD is recognized for its ability to provide pain relief especially for those with chronic pain, joint pain or inflammation. 2023 research shows 22% of American CBD users choose gummies to relieve pain over other forms like topicals or vaping products. Choosing the best CBD gummies can be a bit of a challenge with so many options on the market. He discovered his passion for natural supplements use after suffering from injuries sustained while on Active Duty in the US Army. Remember that finding the right product, dosage, and routine takes time and attention to how your body responds. The precise dosing available in gummy form provides an advantage if you want to carefully track and adjust your intake for optimal results. JustKana’s gummies are made from small-batch extracts designed to support long-term relief, not just dull the pain. Look for formulas with full-spectrum CBD and anti-inflammatory cannabinoids. Do CBD gummies actually help with pain and inflammation? For pain relief, formulation matters more than marketing. Cornbread Hemp Full-Spectrum CBD Gummies Lastly, consider any additional ingredients such as other cannabinoids, terpenes, or natural pain-relieving compounds that may enhance the effects. After researching various options available on the market, it’s imperative to understand the different criteria involved in selecting the best CBD gummies for pain relief. Among the most compelling reasons to consider CBD gummies for pain relief are their potential health benefits, particularly for conditions such as chronic pain, inflammation, and anxiety. For instance, “full-spectrum” CBD products are made using the entire hemp plant, which means that they may contain a wide range of cannabinoids, including CBG, CBN, and even trace amounts of THC. One of the plus sides to CBD oil is that you have more control over the dose than you would with a capsule or gummy. Most CBD types provide similar results, so it's about finding something that works for you and your pain management regimen. You can also look for companies with a 30- or 60-day money-back guarantee if you try a product that doesn't work. These are the perfect CBD daytime gummy for me. We’ve done all the work and identified the best CBD gummies on the market. Small, tasty, discreet, and fun, gummies are a perfect way to knock out your daily dose of CBD. CBG creates energizing, uplifting mental effects, while CBD renders a mild calming effect. We review CBD products on an annual basis and continually make updates throughout the year to provide the most accurate and helpful information. Leafreport’s database provides information and ratings for thousands of CBD products from hundreds of brands, making it easy to search and compare different options. We check products directly from brands so we can try them out before writing reviews and making recommendations. They also like how it’s easy to wash off from hands and doesn’t leave a strong chemical scent like other over-the-counter creams. Customers can’t stop talking about this CBD cream for providing targeted relief. Instead, it tackles the root cause by reducing bodily inflammation, especially after physical activities like running, biking, or even those hardcore CrossFit sessions. This CBD salve boasts 500 mg of CBD per container, which is potent enough to be effective but not so strong that it causes side effects. Topical products may have a naturally or artificially enhanced scent, making them more pleasant to apply. People who like the natural taste of hemp may go for an unflavored product or try something with a natural flavor. Oral CBD products, like CBD oils and gummies, tend to come in various flavors. When you’re ready to try CBD gummies, shop from a source that puts transparency and results first. For chronic pain, CBD gummies can support a long-term pain management plan. The best CBD gummies are backed by third-party lab results and offer consistent dosing so you know exactly what you’re taking. You want CBD gummies that not only taste good, but actually deliver consistent support for your pain management routine. One satisfied user said, “I have never sworn by a gummy like I have this one – have recommended to everyone I know. With a glowing rating of 4.6 stars, it’s clear that Medterra Max Relief Gummies are a hit. Medterra Max Relief Gummies are formulated to provide maximum relief and manage discomfort. Many people with arthritis report relief using CBD for arthritis pain. Choosing high-quality products and starting with a low dose can help reduce the chances of side effects while letting your body adjust. The Arthritis Foundation advises that it’s best to consult a doctor before starting and to use high-quality, clearly labeled products. Additionally, they are free from any artificial colors or flavors, ensuring a clean and natural option for users. The gummies feature a Blackberry Lemonade flavor, often described as refreshing and pleasant, with sour undertones and a hint of fruity sweetness. They are especially suited for light sleepers or those who struggle with occasional sleep disturbances. With no THC, they won’t cause any psychoactive effects or show up on drug tests. Medterra Sleeping Gummies are made with a combination of ingredients that could potentially support a better night’s rest. CBD can provide symptom relief, making day-to-day activities more manageable, but it’s not a cure. One of the most common misconceptions is that CBD gummies can “cure” joint pain. Clearing up these myths helps set realistic expectations for those considering CBD gummies for relief. Alternating between heat and cold can offer balanced relief and is easy to do at home, making it a convenient natural remedy. Cold therapy, such as ice packs, reduces inflammation and numbs the pain, particularly effective for acute pain after physical activity. In recent years, the quest for natural alternatives to manage pain has led to the rise in popularity of CBD gummies. The main thing to keep in mind when you’re using CBD gummies for pain is that they take longer than tinctures to start taking effect. CBD gummies for pain reviews often stop short of what essentials you should be looking for in a gummy. They offer 25 mg CBD per gummy, and customer reviews attest to their quality – even compared with gummies that are supposed to be more potent. Cannabis gummies offer a smoke-free option that delivers measured, long-lasting support, but their effectiveness varies widely. Cornbread Hemp uses USDA-certified organic hemp flower grown in Kentucky to extract CBD. The third-party tests we checked verify the potency and purity of these gummies. These products have received positive reviews from many customers, proving their effectiveness in alleviating muscle aches, soreness, and joint pains. However, some broad-spectrum products don't include THC for more safety. We have mentioned only those CBD products in our list that extract CBD oil from organically grown hemp. Our list of the ten best CBD products for inflammation contains only those companies that have established a reputable brand name in the CBD industry. If you’re always stressed, you should try FOCL Chill Out Gummies. Find top picks for quality, flavor and effectiveness to enhance your wellness. Our detailed guide explores the best Full Spectrum CBD gummies. This table summarizes the top product recommendations and their key features, helping you quickly compare options for sustained relief. Despite a lack of evidence supporting long-term opioid use for arthritic pain, a recent study evaluating prescribing practices found that 12.8% of patients were prescribed opioid medications for knee arthritis (Gwam et al., 2021). Furthermore, it has been reported that up to 50% of patients with arthritis are dissatisfied with the efficacy of anti-inflammatories to treat their pain (Taylor et al., 2013). Medications frequently prescribed to manage the symptoms of arthritis can have unwanted side effects. A systematic review that investigated the use of acetaminophen for pain reduction reported only minimal reductions in pain for patients suffering from hip and knee arthritis, questioning the true efficacy (Leopoldino et al., 2019). This may help reduce the perception of pain and ease inflammation. CBD gummies are edible supplements infused with CBD extract, typically sourced from hemp—a type of cannabis that contains less than 0.3% THC. In this guide, you’ll learn how CBD gummies work, how to choose the best CBD gummies, and discover the 3 best CBD gummies for pain in 2025. On our list, we feature what we believe are the best CBD gummies for pain. Simply eat one or two gummies at a time and wait for the effects to kick in. Choosing the right CBD gummies can be challenging, especially with the wide variety of products available. Though individual results vary, many people find CBD gummies an easy, palatable way to manage joint pain. Many users report experiencing relief from conditions like arthritis, where inflammation contributes to chronic discomfort. For joint pain specifically, CBD’s anti-inflammatory properties may reduce inflammation around the joints, alleviating pain and stiffness. Certain compounds that sometimes find their way into low-grade CBD gummies can reduce the threshold for feeling pain (leading to worsened symptoms). The best CBD gummies for pain contain doses of at least 20 mg and offer clear evidence they’re free from contaminants. Alternatively, you can use delta 8 THC gummies to help with sleep — but be warned, these gummies are psychoactive. All third-party lab results are provided publically on the company’s website for these products. L-theanine is an amino acid that helps with sleep not because of any sedative effects but by reducing anxiety and promoting relaxation to help you fall asleep. It may help reduce the production of these cytokines, which can help reduce inflammation and pain. Moreover, Delta 8 may help reduce inflammation by inhibiting the production of pro-inflammatory cytokines. It has cooling ingredients that rejuvenate your tissues and skin from deep within and provide a natural treatment for everyday pain and fatigue. Experts mixed the highest-quality hemp-derived cannabinoids with mint extracts to create a cooling and calming effect for this topical roll-on. Your skin absorbs the nutrients from this salve and provides instant pain relief. Some high-quality options are gluten-free for those with allergies. Reputable cbd companies always provide lab reports for transparency. In this section we’ll dive into the world of CBD gummies, including their benefits, types and how they can fit into your wellness lifestyle. Unlike other forms of CBD like oils or tinctures, gummies are discreet and easy to take on the go – no measuring or mixing required. Nevertheless, in pathological conditions, inflammation may cause long-lasting pain through activation of sensory neurons . Inflammatory pain is caused by noxious stimuli that occur during the inflammatory or immune response. Δ9-THC has stronger effects on pain reduction than CBD; nevertheless, side effects exclude its clinical use. In a mouse chronic neuropathic pain model involving foramen rotundum inflammatory constriction trigeminal infraorbital nerve injury, CBD administered orally in a peanut butter vehicle alleviated mechanical allodynia within 1 h and remained significant through 6 h . Explore the complete line of RSO products at RickSimpsonOil.com. Backed by decades of success stories, RickSimpsonOil.com remains the only official source for authentic RSO products, formulated to deliver results that standard CBD simply can’t match. Each option on this list provides therapeutic cannabinoids that support the body’s natural recovery. A product that works for muscle soreness may not be strong enough for nerve pain or cancer-related discomfort. Think about which type of CBD best suits your needs before purchasing gummies.Many gummies have artificial sweeteners and synthetic dyes for colors, as well as other undesirable ingredients such as chemical preservatives, high-fructose corn syrup (HFCS), and more.R&R CBD Pain Gummies is a natural way to manage pain.The Raspberry CBD Gummies from Head & Heal cover all the bases when it comes to the most environmentally conscious CBD gummies on the market.Full-spectrum hemp also offers synergistic effects, but it contains traces of THC (less than 0.3% THC by dry weight).PlusCBD offers full-spectrum CBD gummies that leverage the entourage effect in cannabis.This might involve taking a smaller morning dose for baseline relief and a larger evening dose to help control pain while promoting better sleep.Sunmed’s products are derived from organic hemp cultivated in Colorado and Oregon.Place your order today and start enjoying the benefits of natural pain management. Also, keep in mind that CBD products aren't standardized and will vary. Dispensary products must be labeled so you can see exactly how much CBD is in the product and whether it also contains THC. If you are interested in trying a CBD product, it's best to seek one through a dispensary, which is an establishment legally licensed by a state to sell marijuana products — if such a dispensary is available in your state. How fast does CBD work for joint pain relief? A high-quality product starts with real, hemp-derived CBD and follows through with clean ingredients, proper testing, and clear labeling. Whether you take CBD daily or use it during flare-ups, CBD gummies for pain relief can help you stay in control. CBD gummies stand out as a go-to option for pain relief thanks to their blend of convenience and effectiveness. CBD gummies for pain have become a go-to CBD product because they combine effective ingredients with ease of use. CBD is known for its calming effects, and gummies make it easy to integrate stress relief into your day .Royal CBD gummies contain all-natural ingredients, including colorings and flavorings.CBD gummies are a unique CBD product because they include an element of food.Recognized as one of the best CBD gummies for pain and inflammation relief in 2023, Otterspace CBD Gummies stand out for their exceptional taste, making them a popular choice among users.In addition to surgically induced neuropathy, chronic pain can be triggered by chemical substance administration.Possibly the most common conditions that benefit from CBD are arthritis and asthma – both are greatly benefitted from minimizing inflammation.Overall, preclinical and clinical data support the potentially effective anti-inflammatory properties of endocannabinoid agonists that target CB2 receptors.In fact, these studies merit further research to confirm how CBD may reduce inflammation and potentially help treat a wide variety of conditions marked by chronic inflammation. Whether used topically for targeted relief or orally for systemic support, CBD can be a valuable addition to a natural arthritis management plan. CBD gummies for pain may offer lasting relief, especially when taken regularly. CBD oil and CBD oils and tinctures are trusted choices for pain relief because of their fast absorption and flexible dosing. Both may offer the entourage effect which can improve pain relief. Broad-spectrum CBD and full-spectrum CBD may have different effects due to the entourage effect from other cannabinoids like delta-9-THC or cb2 receptor activity. Hemp derived cbd products are preferred for their legal compliance and safety. A healthcare professional can help you determine the right type of CBD product, the right dosage and how to safely incorporate CBD into your pain management plan. CBD edibles include gummies, chocolates and baked goods, convenient and flavorful options for natural relief.CBD gummies use cannabidiol (CBD), the non-psychoactive part of cannabis plants. The sweet flavor masks CBD’s natural earthiness, making it more palatable for regular use. The pleasant experience of consuming gummies shouldn’t be overlooked as a factor in consistency of use. Gummies can be taken anywhere without drawing attention or requiring special equipment, making them suitable for maintaining your pain management routine at work, while traveling, or in social situations. When controlling for age, dose, gender, the type of arthritis was not found to be an independent predictor. Between the different arthritis types, a larger percentage of patients with osteoarthritis (66.2%) reported reductions in other medications used compared to RA (56.3%) and autoimmune arthritis (53.7%). Cannabinoids have been shown effective in human trials for chronic pain (Campbell et al., 2018; Moeller-Bertram et al., 2019; Wiese & Wilson-Poe, 2018). These findings suggest that CBD could be an alternative to opioids for the treatment of arthritic pain. Given the severity of the current opioid epidemic, finding alternative treatments for pain is vital to public health (Mattson et al., 2021). To determine the effectiveness of CBD gummies in treating health issues, it’s crucial to know how many milligrams of CBD they provide. Coating the gummies doesn’t provide the most effective results, so it’s best to opt for infused gummies. They don’t contain THC, though some products may have trace amounts. However, we only recommend CBD products that contain 0.3% or less, which is the legal amount for CBD products in the U.S. Most gummies are made from hemp oil that contains 0.3% THC or less because that amount isn’t enough to make you feel high. If you purchase an independently reviewed product or service through a link on our website, Rolling Stone may receive an affiliate commission. However, if they help ease various symptoms, you may feel much better when taking CBD gummies regularly. Talk to your healthcare provider about your intentions for CBD and what dosage might be best for you. The proper dose depends on your weight, whether you’ve ever used CBD before and why you’re taking it. A. An individual CBD gummy can contain anywhere from 1 to 100 milligrams of CBD, but most have between 10 and 50 milligrams. CBD may also help improve sleep and stress levels, two factors that influence how the body processes discomfort. There is growing evidence that CBD helps with several types of pain, especially when combined with good habits like stretching, hydration, and rest. By impacting these pathways, CBD may provide both physical and emotional support for those managing persistent pain. By interacting with receptors in this system, CBD can help reduce pain signals and promote a sense of balance within the body. CBD gummies provide a simple and enjoyable way to take CBD daily. As someone who has spent years researching and writing about natural wellness solutions, I’ve seen firsthand how CBD products have transformed pain management approaches for many individuals. If you’re among the millions searching for natural alternatives to traditional pain management, CBD gummies have likely appeared on your radar. The key to using CBD effectively for inflammation is to ensure you’re only using high-quality, full-spectrum extracts that have been confirmed to be free from contaminants through third-party testing. We think they’re the best CBD pain relief gummies out there, delivering 25 milligrams of fast-absorbing, extra-strength nano CBD throughout your system. If you’re looking for a strong CBD for pain relief, check out this cream from CBDfx. Each gummy contains a blend of broad-spectrum hemp extract, organic MCT oil, tapioca syrup, organic cane sugar, natural flavors, natural colors, and coconut oil.Comparison of socioeconomic demographics and CBD utilization based on type of arthritis between group comparisons of participants by type of arthritis and patterns of CBD utilizationBut those intense workouts can leave you battling muscle soreness and inflammation.However, there are some added benefits for this type of CBD product in terms of the flavor, convenience of dosing, and portability.Keeping a journal of your intake and pain levels can help you identify patterns and optimize your approach.As you can see from our list, gummies can be found in a wide range of potency – anywhere from 5mg to 100mg per gummy.It’s easy to see why—the best CBD gummies combine convenience, great taste, and consistent dosing, making them a favorite among CBD users. Finding the right cannabis gummy depends on your body, your tolerance, and the type of pain you’re managing. Available online through LazarusNaturals.com and shipped across the U.S., these gummies are a trusted choice among patients seeking affordable, effective full-spectrum relief. Known for consistent dosing and an indica-forward profile, these gummies are often used for evening relief, helping ease muscle tension, inflammation, and stress-related discomfort. Most users don’t report issues, but it’s best to get a quick clearance if you’re on prescriptions. People managing arthritis, sciatica, or muscle soreness report reduced inflammation and improved mobility. Because gummies are absorbed through digestion, the onset is slower than vaping but the effects last longer, typically 4–6 hours. Most users report noticeable relief within 30–90 minutes of taking a gummy. Made from 100% natural ingredients, Cheef Botanicals CBD gummies present a healthier choice for pain and inflammation relief. Exhale Wellness has established itself as a reputable provider of premium CBD products, and its CBD gummies excel in offering potent pain and inflammation relief. This cooling sensation can help to alleviate pain and reduce inflammation, making it a popular ingredient in topical pain relief products. Although isolated CBD gummies may help you relax, their effects are non-synergistic and often milder than those of broad or full-spectrum hemp products. In essence, CBD gummies are great for pain relief because they contain the same active ingredient as all CBD products. There are different ways that hemp is grown, but it’s best to opt for hemp that’s either organic or sourced from the European Union—and any local sourcing should earn a brand extra brownie points. It’s best to check in with your doctor about specific dosages, but when looking at hemp CBD gummies, you’ll often see each serving providing between 10 to 50mg of hemp CBD. Wild Theory opts for a CBD isolate (from organic hemp grown on local family farms in Wisconsin) rather than a full- or broad-spectrum hemp extract, so you won’t find any traces of THC. This review summarizes the chemical and biological effects of CBD and its natural and synthetic derivatives. It is non-psychoactive, but has many beneficial pharmacological effects, including anti-inflammatory and antioxidant effects. Here, we review the main biological effects of CBD, and its synthetic derivatives, focusing on the cellular, antioxidant, and anti-inflammatory properties of CBD. CBD is non-psychoactive but exerts a number of beneficial pharmacological effects, including anti-inflammatory and antioxidant properties. He’s also written third-party lab test reports of CBD products and knows the industry inside and out. This process means that there is no way for any harmful chemicals or other unnatural additives to make their way into your body when using these gummies. We know that this company only uses organic ingredients, but it’s still reassuring that an outside source had looked over the formula before it was released to consumers. The tests performed on these CBD gummies showed less than 0.3% THC, meaning they won’t cause any psychoactive effects. For example, their Sleep gummies incorporate 3mg of melatonin. Furthermore, these gummies can be purchased in different formulas for certain conditions. Each of their gummies is loaded with 25mg of CBD and 2mg of tetrahydrocannabinol (THC) to ensure you’ll experience the entourage effect. Admittedly, these extracts are tied down to specific formulas (for example, the Sleep Tight gummies can only be purchased in isolate). These reports from accredited labs not only confirm the potency of a product, but they also confirm that contaminants, like heavy metals, microbials like mold, and pesticides, are absent or in negligible amounts. Any hemp CBD you purchase should have third-party testing data and an accessible certificate of analysis (COA). These ingredients aren’t necessarily “good” or “bad,” they’re just something you should be aware of when narrowing down your options. Hemp CBD is extracted from the industrial hemp plant, which is also called Cannabis sativa. Additional organic flavoring comes from pineapple and mango, and the final product is dusted in citrus fiber to replicate that sugar-dusted coasting seen on many popular candies. While CBD oils tend to be more concentrated and are a more direct route into the bloodstream, many people are unable to tolerate the taste or texture. CBD is praised for treating insomnia, warding off nasty side effects of chemotherapy, and lowering anxiety. Broad-spectrum CBD has gone through an additional extraction process to remove all the THC components of the extract. Those subject to drug testing should steer clear of full-spectrum CBD. Full-spectrum CBD is legal for sale in the U.S. when THC levels are tested and come in at less than .30 percent of the total weight. Preclinical and clinical studies suggest a potential anti-nociceptive effect of CBD and CBD combined with other compounds in several pain-related diseases. More of the pharmacological effects of CBD, including the modulation of cytokine factors, cell function and reactive oxygen species may be found in the appendix table in the paper by McPartland et al., 2014 . Moreover, studies by Juknat et al. revealed that nuclear factor erythroid-derived 2-like 2 (Nrf2) was responsible for CBD-mediated modulation of inflammatory gene expression patterns in activated microglia cells . One of the more important targets of CBD is the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ), especially in the context of inflammation. The cytochrome P450 superfamily (CYPs) of enzymes is of particular interest as the interaction between CBD and CYPs may influence clearance of various drugs, including very commonly used, non-steroidal anti-inflammatory drugs. Ingredients Quality If you’d rather chew your pain relief product, check out these Mission Farms CBD gummies. CBD products for pain relief are most effective when used daily. Broad-spectrum CBD is often used for its wide range of benefits, such as pain relief, anxiety reduction, and sleep support, without the inclusion of THC. We hope this article has helped you decide which cbd gummies for inflammation and pain is best for your needs. A crucial aspect is assessing the quality of ingredients used in the CBD gummies. CBD gummies are gaining popularity as an alternative treatment option for pain and inflammation. For individuals experiencing poor sleep due to anxiety, chronic pain, or other health issues, CBD gummies may offer a promising solution. The fact that CBD offers natural stress relief without causing psychoactive effects makes it an appealing option for many individuals seeking anxiety relief. Carmen’s Medicinals Broad Spectrum Gummies stand out as one of the best options for pain and inflammation relief in 2023. Since the FDA doesn’t regulate CBG gummies, you have to. To decrease your risk of feeling these effects, use a dosage formula that’s based on your weight so you don’t take too much CBG in the beginning. For most people, this dose will be between 10 and 25 milligrams. More research is needed on whether CBG is a viable treatment for anxiety, but it’s clear from this survey that CBG may promote a clear, anxiety-free headspace. Not only do we appreciate Elixinol’s transparency, but we also find its choice of added ingredients particularly poignant. Products that contain more milligrams of CBD per dose have greater effects. We also consider things like the form of CBD used (full-spectrum is best, followed by broad-spectrum for those who don’t like or can’t have THC) and CBD potency. Things like omega-3 fatty acids, turmeric (curcumin), and coenzyme Q10 (CoQ10) can make a CBD product even more likely to relieve some of your worst arthritic symptoms. Natural flavors like mixed berry flavor make these cbd edibles tasty while supporting stress relief, anxiety relief, sleep support or pain relief in a gentle way. There are many CBD companies offering gummies and their products can vary in quality, ingredients and potency. Two of the more commonly utilized medications that participants used for pain relief for arthritis were non-steroidal anti-inflammatory (NSAIDs) and acetaminophen. For pain relief, full-spectrum tends to outperform the rest due to the synergistic effect of multiple cannabinoids working together. They reported less anxiety and better mood, sleep, and quality of life, and showed no serious negative side effects. Using CBD products can also cause side effects. CBD products are thought to work by stimulating your CB1 and CB2 receptors, along with several other systems in your body, to cause different effects. What are CBD Gummies for pain, and how do they work? If you have chronic pain, then you may want to consider adding CBD into your day-to-day. Depending on your body’s reaction, it’s not an exaggeration to say that the added CBD could just give you back your life. These gummies can certainly help with that. CBD is especially beneficial for helping with pain after physical activity, according to a 2019 survey conducted by CBDistillery. If you’re seeking a more comprehensive experience, full-spectrum gummies could offer the best results. CBD gummies are chewy, edible candies infused with cannabidiol (CBD), a natural compound found in the hemp plant. These gummies use natural ingredients and are pectin-based, making them vegan-friendly. The gummies are described as pleasant and tasty, featuring natural hemp flavors. These CBD gummies may have been designed to help you stay alert without the jitters, but the benefit of the CBD, sans the caffeine, will help ease your pains, too. This hemp gummy is made with premium, hand-infused hemp without any hidden sugars or chemicals. These CBD Isolate gummies are gluten-free, vegan, and third-party tested for the highest quality available. These CBD gummies use a CBD Isolate to make sure you’re getting the CBD you want and only the CBD – no risk of THC, whatsoever. The most effective form of CBD depends on your desired outcomes and how quickly you want to feel the effects. If you suspect an allergic reaction, discontinue use immediately and seek a healthcare professional. For example, CBD can affect the liver’s ability to metabolise drugs, potentially altering their effectiveness or causing unwanted side effects. CBD contains trace amounts of THC and other cannabinoids, which may interact with certain medications. As mentioned, the industry is currently unregulated and has allowed plenty of people to profit off this market with low-quality and ineffective products. Therefore, people struggling with chronic pain may find more benefits from medical marijuana rather than CBD products. For this reason, CBD gummies are an optimal solution for those seeking out long-term pain relief. Of course, you may find Lazarus Naturals other gummies to be better for pain relief, depending on your preference. When we get cuts in the skin or stub our toe, we experience acute inflammation. Acute inflammation refers to short-term inflammation — typically less than six months in duration. The most important distinction to make is whether the inflammation is acute (short-term) or chronic (long-term). Stopping inflammation means blocking these chemical messengers. This reduces the risk of your child consuming any amount of tetrahydrocannabinol (THC) and experiencing psychoactive effects. If you plan on giving cannabidiol to your child, we suggest making sure the extract is either broad-spectrum or CBD isolate. CBD-infused gummies are the most effective consumption method for children. By taking a gummy, you should notice your muscles relaxing and discomfort levels dropping. Some users who have used gummies for anxiety found that they can be effective when taken before an anticipated stressful situation. Other common ingredients include methylsulfonylmethane (MSM, a sulfuric antioxidant and anti-inflammatory compound), turmeric, collagen, omega-3, vitamin D, vitamin K, and black pepper extract (which improves our body’s absorption capabilities). Most of these support people with arthritis, but clinical studies suggest they work best for people with osteoarthritis. (Granted, it’s likely less expensive to purchase an omega-3 supplement if you don’t live near an ocean.) And both options are going to be less expensive than a CBD product. With arthritis, your two primary options are full-spectrum CBD oil tinctures and topicals. More transparency about these ingredients could make us recommend Receptra Naturals' product more highly. While the prices are quite reasonable, you can also use the code “natural20” to get further discounts on its products. Each product — from its soothing drops to functional gummies — is lab-tested for quality assurance and safety. FOCL is one of the most reputable brands offering premium quality CBD and THC products to boost mood, enhance focus, promote calm, and even improve sexual performance. If you travel internationally, research the legal status of CBD at your destination, as having CBD products in your possession could potentially lead to serious legal consequences in certain jurisdictions. The legal status of CBD products varies by location, making it important to understand the regulations in your specific area. Some users actually benefit from this effect, especially when using CBD for pain that interferes with sleep. Dry mouth is among the most commonly reported effects, resulting from CBD’s interaction with salivary production. For example, 4-hydroxynonenal (4-HNE) has been identified as a stimulator of the cytoprotective transcription factor Nrf2, an inhibitor of antioxidant enzymes (e.g., catalase and thioredoxin reductase) and a pro-inflammatory factor acting through the NFκB pathway . In addition, the propagation of oxidation chain reactions, especially with regard to docosahexaenoic acid, can lead to oxidative cyclization, resulting in production of isoprostanes or neuroprostanes . Repeated doses of CBD in inflammatory conditions were found to increase the activity of glutathione peroxidase and reductase, resulting in a decrease in malonaldehyde (MDA) levels, which were six times higher in untreated controls . CBD also reduces reactive oxygen species (ROS) production by chelating transition metal ions involved in the Fenton reaction to form extremely reactive hydroxyl radicals . CBD oil is typically extracted from hemp, a variety of cannabis with low THC levels. Talk to your doctor before using CBD, especially if you’re taking other medications that could interact with CBD. Research seems to suggest it’s safe to consume CBD daily, in doses up to 400 milligrams. Some research suggests that cannabis enhances people’s sexual experience by helping them relax. If there's any THC in a CBD product that you use, then you could test positive for THC and fail a drug test. A particularly interesting, although anecdotal, result has recently been published by Chelliah et al., who described the benefits that CBD provided as anti-inflammatory agent in three patients affected by epidermiolysis bullosa. A topical transdermal gel containing a proprietary and patent-protected CBD formulation is being developed by Zynerba Pharmaceuticals (Devon, PA, USA) and is currently in clinical development for the treatment of epilepsy, developmental and epileptic encephalopathy, fragile-X syndrome and osteoarthritis 96,97,98. An ethosomal formulation for CBD, which consisted of 3% CBD and ethanol in a carbomer gel, has been prepared by Lodzki et al. , and its anti-inflammatory effect was tested on carrageenan-induced aseptic paw oedema in a mouse model. The evaluation stages for the transdermal administration of cannabinoids range from early preclinical phases and mouse models, to self-initiated topical use and randomized, double-blind controlled studies. Furthermore, transdermal administration allows a steady infusion of a drug to be delivered over a prolonged period of time, while also minimising the adverse effects of higher drug peak concentrations, which can improve patient adherence. If you want something that has an immediate response, then the oils will be your better bet, because the effects are almost immediate after dropping a CBD oil tincture under your tongue. It may be worth considering your body’s response to sugar before committing to a CBD gummy. They’ll give you a baseline of CBD support that may very likely offer some decrease in your inflammation. It’s especially beneficial to reducing chronic pain. Only products from Vitality Biopharma (cannabinoid prodrugs) seem to be designed for a targeted approach to the gut. Conclusions in studies into reducing opioid doses in the management of chronic pain, where some trials have shown clinical benefits, are sometimes not completely reliable as they inadequately report dose changes and have mixed results in analgesic effects . Furthermore, Mücke et al. have also declined to share in the optimistic conclusions that cannabis-based medicines are effective, well-tolerated and safe in the treatment of chronic neuropathic pain, due to a lack of high-quality evidence for their efficacy . Depending on the size of the bottle, CBD gummies can range anywhere from $10 to over $100. CO2 extraction creates some of the purest CBD gummies available with current technologies. There are many different ways to extract CBD from industrial hemp. CBD potency can vary greatly between products, so finding the right strength for you is key.We also need to take into account whether the inflammation is caused by physical damage or an allergic or autoimmune reaction.Gleb specializes in CBD and has personally tried and reviewed dozens of CBD products.CBD gummies have become so ubiquitous, that’s it’s hard not to find them.Additionally, Charlotte’s Web offers two more blends; their Sleep and Recovery gummies.Sunday Scaries suggests each serving size to be 2 to 3 gummies, and each purchase will get you 20 gummies.Additionally, it’s important to recognize the type of CBD used in the gummies. Not all CBD gummies are created equal, especially when it comes to pain management properties. This predictability is especially valuable for pain management, where finding and maintaining an effective dose is crucial for sustained relief. This is particularly significant because many conventional pain medications become less effective over time as patients develop tolerance, requiring increased dosages and risking side effects. For neuropathic pain specifically, a 2018 review in Frontiers in Pharmacology highlighted CBD’s potential to suppress chronic inflammatory and neuropathic pain without causing analgesic tolerance. The study suggested that CBD doesn’t just mask pain but may address underlying inflammatory causes. Their high lipophilicity and low stability (degradation via the effects of temperature, light and auto-oxidation can occur) mean that cannabinoids benefit greatly from nanotechnology approaches . In order to complete this overview of topical CBD, we should note that CBD exerts interesting sebostatic and anti-inflammatory effects on human sebocytes , (data obtained from in vitro evaluations). Improved anti-inflammatory effects can be obtained from a composition containing boswellic acids, either isolated from Boswellia family plants (Buseraceae) or in the form of an extract, and either CBD or a Cannabis sativa extract . Siukus has presented an oleo gel composition made up of non-psychoactive Cannabis sativa components for the treatment and/or reduction of deep tissue joint and muscle inflammation caused by mechanical skeletal muscle trauma and arthritis/osteoarthritis. These pharmacokinetics (rapid onset, short time peak effect and intermediate lasting effects) occur because first passage metabolism is avoided and are thus virtually impossible to replicate with the oral administration of cannabis or cannabinoids. Our recommended list of the ten best CBD strains for inflammation constitutes the best products to soothe muscle soreness and pain. When CBD and menthol are combined, they work together to provide even greater pain relief and anti-inflammatory benefits. Several ingredients in these gummies are natural pain relievers rich in cooling properties. All these ingredients make this Rapid Recovery Cream a powerhouse of pain relief. In our study population, 41% of respondents taking CBD for their arthritic pain reported at least one side effect. Considering these findings, we performed a logistic regression analysis controlling for age and gender to determine the influence of arthritis diagnosis and the frequency and length of CBD use on the reduction/cessation of other medications. However, these differences were largely due to a higher proportion of individuals with autoimmune arthritis not knowing their daily dosage (Table 5). In our assessment of pain reduction after using CBD, participants were asked to rate their pain before and after using a numerical pain score (0–10).