After treatment sessions, patients reported reduced pain, improved sleep quality, and reduced insomnia and fatigue 112,113,114,115. However, Finn et al. proved that CBD alone did not reduce nociception in a rat model of persistent pain, in contrast to Δ9-THC, morphine and its combinations, and did not modulate Δ9-THC’ anti-nociceptive effects . In a 6-hydroxydopamine-induced Parkinson’s disease mouse model, CBD exerted analgesic effects by increasing anandamide binding to the CB1 and TRPV1 receptors. In a rat model of myofascial pain (induced by nerve growth factor intramuscular injection), intramuscular injection of CBD or cannabinol (CBN) decreased mechanical sensitization and increased the mechanical threshold of masseter muscle mechanoreceptors . In a spontaneous canine OA model, CBD increased dogs’ mobility and reduced pain, while no side effects were observed, Gamble et al. demonstrated increased alkaline phosphatase during CBD treatment 81,86. Therefore, Δ9-THC has been a natural subject of thousands of studies concerning pharmacology, toxicity and the therapeutic potential of cannabinoids in the intervening years. In order to find compounds with a greater therapeutic profile and activity than CBD, without any adverse effects, the biological properties of both natural and synthetic CBD derivatives were checked, with the hope of finding the perfect derivative that provides a close to ideal therapeutic effect. Until recently, CBD was thought to have only low toxicity to humans and other species , but recent studies indicate an increase in ALT and AST levels after CBD treatment, which disqualifies it as the drug of choice 135,136. It is believed that the endocannabinoid system, which includes G-protein coupled receptors and their endogenous lipid ligands, may be responsible for the therapeutic modulation of oxidative stress in various diseases. It can help relieve muscle pain, joint discomfort, back sprains, or cramps that just don’t let you sleep at night. When you’re in pain, you want something strong enough to make a difference. If you’re tired of taking medicines that take hours to work, you’ll be glad to know that these drops are formulated for sublingual use, ensuring rapid absorption and quick relief. Furthermore, hydrogenated CBD derivatives such as (+)-dihydrocannabidiol and (+)-tetrahydrocannabidiol have CB1 receptor affinity (Table 2) and show anti-inflammatory effects on the peritoneal cells of C57BL/6 mice and a macrophage cell line. The derivatives with potential antioxidant and anti-inflammatory effects include, but are not limited to, (+)-CBD derivatives, dihydrocannabidiol and tetrahydrocannabidiol derivatives, and (+)-dihydro-7-hydroxy-CBD . CBD has also been suggested as a therapeutic compound for the treatment of painful diabetic neuropathy due to its ability to activate 5-HT1A receptors . CBDmd CBD Gummies Each product — from its soothing drops to functional gummies — is lab-tested for quality assurance and safety. FOCL is one of the most reputable brands offering premium quality CBD and THC products to boost mood, enhance focus, promote calm, and even improve sexual performance. These gummies can help ease those annoying cramps and mood swings, making PMS a bit more bearable. These CBD gummies contain a total of 750 mg full-spectrum CBD and 5 mg THC. Recently, the World Health Organization released a critical review on CBD and found it is generally well tolerated with a good safety profile and does not have abuse potential (Expert Committee on Drug Dependence, 2018).CBD offers a natural, plant-based option for pain relief, making it a game-changer for those looking to avoid pharmaceuticals or harsh side effects.For this question, participants could “check all that apply.” On the basis of the distribution, many patients had pain in multiple joints.In several studies of PAC-induced neuropathic pain, CBD exerted a positive effect against mechanical and thermal allodynia in mice and prevented mechanical sensitivity.The THC delivers a slight hazy feeling that amplifies the relaxing effects of the CBD and CBN.Just throw it in the bag and apply it whenever you feel like the pain is creeping up.Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly the first line of analgesia.A crucial aspect is assessing the quality of ingredients used in the CBD gummies. Without a proper control condition (i.e., placebo), it is difficult to determine the role that expectancy effects contributed to the observed reductions in pain in these open-label trials. Daily CBD dosing regimens have reduced pain in clinical populations in several small, single-arm open-label studies. To date, there are no completed randomized clinical trials that have evaluated a repeated CBD treatment regimen in patients with clinical anxiety disorders. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. In addition, THC was found in 18 products. Another cause for concern is the unreliability of the purity and dosage of CBD in products. Though it's often well-tolerated, CBD can cause side effects, such as dry mouth, diarrhea, reduced appetite, drowsiness and fatigue. These reactions reduce the level of reactive lipid peroxidation products, while increasing the formation of adducts with proteins that promote cell signaling disorders, thus stimulating metabolic modifications that can lead to cellular dysfunction and apoptosis 47,48. The formation of lipid peroxidation products directly affects the physical properties and functioning of the cell membranes in which they are formed . As a result of the ROS reaction with PUFAs, lipid hydroperoxides are formed, and as a result of oxidative fragmentation, unsaturated aldehydes are generated, including 4-hydroxynenenal (4-HNE), malonodialdehyde (MDA) or acrolein . Oxidative modifications play an important role in the functioning of redox-sensitive transcription factors (including Nrf2 and the nuclear factor kappa B (NFκB). CBD gummies have rapidly gained popularity as a preferred choice for pain relief, primarily due to their ease of use and enjoyable taste. Promising results from studies on animal models indicate that CBD may effectively alleviate neuropathic and inflammatory types of pain. This suppression helps reduce swelling at injury sites and provides relief from chronic pain conditions like arthritis or muscle strains. Finding the best CBD gummies for pain relief involves balancing potency, spectrum type, and quality. Despite these early findings and data from two case reports in which CBD improved sleep quality in a single pediatric patient with PTSD and four patients with Parkinson’s disease 43, 44, we identified only one randomized, double-blind, placebo-controlled, study with sleep as the primary outcome measure. The efficacy of CBD as a hypnotic was examined in one study with healthy individuals who reported difficulty falling or staying asleep. One double-blind randomized controlled trial evaluated CBD’s effects on patients with Huntington’s disease. In one double-blind study of patients with Parkinson’s disease, six weeks of oral CBD (300 mg/day) improved self-reported functioning/well-being but did not alter clinically-observed disease symptoms (assessed via the Unified Parkinson’s Disease Rating Scale, UPDRS) relative to placebo . Following CBD treatment, participants retrospectively reported decreased euphoria when using cannabis (Cannabis Experience Questionnaire), but cannabis use frequency and quantity did not change from baseline . Cornbread Hemp Full-Spectrum CBD Gummies Early research shows it may be used to treat side effects of cancer treatment. A cannabinoid that might help reduce inflammation and pain from inflammation. CBD has a host of potential benefits and can be helpful in counteracting some of the more intense effects of THC. Delta 8, Delta 9, Delta 10, HHC, THC-V, THC-O, THC-P THC products have psychoactive effects. Meanwhile, turmeric acts as a natural anti-inflammatory, and Panax ginseng supports energy, endurance, and general wellness. At this same CBD dose, in epilepsy patients who were also using valproate and clobazam, 30% of these patients exhibited over 3x the upper limit of normal alanine transaminase elevations . For example, GW Pharmaceuticals reported that 17% of epilepsy patients using 20 mg/kg/day CBD (Epidiolex®) exhibited over 3x the upper limit of normal alanine transaminase elevations. The incidence of severe adverse events resulting from CBD administration appears low based on review of these studies. Adverse events were often a secondary endpoint in the clinical trials and laboratory studies reviewed in this manuscript. Li et al. have shown that intraperitoneal (i.p.) CBD injections attenuated pro-inflammatory cytokine and chemokine invasion and prevented thermal sensitivity development . However, Δ9-THC and CBD co-administration provided a 200-fold increase in low dose efficacy, with no side effects observed (only high co-administered doses caused side effects, similar to those seen with Δ9-THC alone) . Costa et al. also observed a reduction in the content of several pain mediators (prostaglandin E2 plasma concentration and paw tissue malondialdehyde, nitric oxide and glutathione-related enzymes levels) in response to 20 mg/kg oral administration of CBD. CBD effectiveness was also demonstrated in a chronic constriction injury (CCI) animal model of neuropathic pain. In rats, after ligation of the L5 spinal nerve, CBD and its modified derivatives (dihydroxyl-CBD, and didesoxy-CBD) suppressed chronic neuropathic pain. Third, patients with polarizing views on experiences using cannabinoids—whether they are positive or negative—may be more likely to have participated in the study, which could lead to either positive or negative bias. This higher prevalence may be due to a selection bias secondary to patients who have used CBD being more likely to participate in the study. The authors feel it is unlikely that 70% of patients with arthritis in the general population have tried CBD. When consumed, Delta 9 THC in the gummies binds to the CB1 and CB2 receptors in the ECS, much like the body's endocannabinoids would. The ECS consists of endocannabinoids, receptors, and enzymes, and it's through these components that Delta 9 THC exerts its effects. While these treatments can be effective, they also come with potential side effects, such as gastrointestinal issues and increased risk of infections. The aggressive marketing of these products paired with the lack of regulation and quality control has the potential to cause a significant negative impact on public health. He had legally purchased “CBD gummies” marketed for pain and anxiety relief three hours prior to his presenting to the emergency department, hoping they would help relieve pain from a recent back injury (Figures 1, 2). Healthy controls were also recruited and used as a comparator to SAD patients, but did not receive CBD treatment.They provide a comprehensive blend of cannabinoids and terpenes to effectively soothe inflammation and alleviate discomfort.With chronic pain affecting millions of people worldwide, many are seeking natural, effective alternatives to traditional painkillers.To date, there are no completed randomized clinical trials that have evaluated a repeated CBD treatment regimen in patients with clinical anxiety disorders.The CBD oil is free from preservatives, gluten, and dairy, aligning with health-conscious pet owners’ preferences.The discreet nature of CBD gummies makes them ideal for on-the-go usage, making them perfect for individuals seeking pain alleviation during busy days.Adverse events were often a secondary endpoint in the clinical trials and laboratory studies reviewed in this manuscript.Traditional treatments for inflammation often involve non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and other medications.The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.Questions consisted of “yes/no” and “select one of the following.” Questions regarding previous treatment modalities, the anatomical joint involved, and medications were in “check all that apply” formatting. Previous cross-sectional analyses have found at least one reported side effect in 29–59% of patients using CBD for different indications which is in concordance with our findings (41%) (Corroon & Phillips, 2018; Devitt, 2019; Moltke & Hindocha, 2021). Recently, the World Health Organization released a critical review on CBD and found it is generally well tolerated with a good safety profile and does not have abuse potential (Expert Committee on Drug Dependence, 2018). Cannabidiol could have unwanted side effects and/or interactions with other medications. Although CBD is available for purchase without consultation with a doctor, the authors recommend that patients discuss this with their doctor before use. These gummies may contain up to 2mg of THC per gummy, delivering a full-spectrum experience. Vegan, GMO-free, and made in the USA, these gummies are free from artificial sweeteners or high fructose corn syrup. These gummies contain broad-spectrum CBD, providing most cannabinoids except THC. FOCL ensures its CBD gummies consist of natural ingredients without harmful additives or chemicals. Best CBD Gummy Flavor Varieties: Sunday Scaries Extra Strength CBD Gummies The latest study by Lowin et al. showed that in human in vitro culture of rheumatoid arthritis synovial fibroblasts, CBD increases intracellular calcium levels, reduces cell viability, and IL-6/interleukin 8 (IL-8)/MMP-3 production.Organic compounds that provide some of the aroma and flavor found in cannabis and a variety of other organisms, including plants.Furthermore, hydrogenated CBD derivatives such as (+)-dihydrocannabidiol and (+)-tetrahydrocannabidiol have CB1 receptor affinity (Table 2) and show anti-inflammatory effects on the peritoneal cells of C57BL/6 mice and a macrophage cell line.These gummies are made with 100% organic ingredients, so you won’t have to worry about weird chemicals.Their activity through membrane receptors is emphasized, which are described in this review as those which under the influence of CBD show antioxidant and/or anti-inflammatory activities.While the prices are quite reasonable, you can also use the code “natural20” to get further discounts on its products.The chemistry and pharmacology of CBD, as well as various molecular targets, including cannabinoid receptors and other components of the endocannabinoid system with which it interacts, have been extensively studied. In Lennox-Gestaut syndrome, a rare and severe childhood-onset form of epilepsy, oral CBD reduced seizure frequency and improved patients’ overall conditions but triggered adverse effects (somnolence, decreased appetite, diarrhea; more severe in higher doses groups) 106,107. A transdermal CBD-containing gel in patients with peripheral neuropathic pain mitigated pain, as well as cold and itchy sensations . In a corneal hyperalgesia mouse model, CBD produced anti-nociceptive effects and reduced neutrophil-infiltration in a wild-type and CB2 knock-out mice. CBD, depending on the concentration, can activate, antagonize or inhibit cannabinoid receptors (CB1 and CB2), as well as ionotropic (TRP) and nuclear (PPAR) receptors (Figure 4) 52,59,60. However, it is known that the peroxisome proliferator-activated receptor alpha (PPAR-α), for example, activated by endocannabinoids, directly regulates the expression of antioxidant enzymes such as superoxide dismutase by interacting with their promoter regions . One of the most noticeable CBD antioxidant effects is the reduction in lipid and protein modifications 25,51. Unfortunately, in this study, CBD did not reduce carrageenan-induced hyperalgesia. Similar effects were obtained with oral CBDA and Δ9-THC administration. In two additional murine models of induced inflammation, using 2.5% Croton oil in acetone topically applied to the ear or by i.p. It is usually accompanied by redness, heat, swelling, pain/hypersensitivity, and loss of function. Under normal conditions, inflammation is a crucial protective mechanism, which plays an important role in the wound healing process. Improved Sleep Quality Recognized as one of the best CBD gummies for pain and inflammation relief in 2023, Otterspace CBD Gummies stand out for their exceptional taste, making them a popular choice among users. BATCH CBD gummies are an effective choice for pain and inflammation relief, carefully crafted using premium hemp oil sourced from Colorado. Many people find it convenient to keep a stash of CBD gummies in their bag or car for quick relief from inflammation, joint pain, or muscle soreness while out and about. For example, a study on rats with induced arthritis demonstrated that local administration of CBD significantly reduced joint swelling over time without any evident side effects during treatment. Contributing to this diagnostic dilemma is the fact that the majority of these products are synthetic which allows for a larger spectrum of cannabinoids and much higher concentrations than would be found in natural sources. In both scenarios, more of the CBD-labeled product was consumed than was recommended, and both patients required short-term hospitalization. The pediatric patient consumed CBD oil, whereas the 56-year-old man ingested CBD gummies. While the patient recovered, the exact constituent which caused the clinical findings mentioned was not able to be established due to lack of consistent formulations, purity, and potency of the commercially available products . In a recent open-label study involving patients with chronic pain and more than 2 years of opioid use, 53.2% of participants were able to reduce opioid medications, lessen their pain, and improve sleep quality after 8 weeks of consuming oral CBD hemp extract (Capano et al., 2020). Given the severity of the current opioid epidemic, finding alternative treatments for pain is vital to public health (Mattson et al., 2021). These conflicting findings support the need for safe, alternative treatments for patients to manage their pain. A systematic review that investigated the use of acetaminophen for pain reduction reported only minimal reductions in pain for patients suffering from hip and knee arthritis, questioning the true efficacy (Leopoldino et al., 2019). However, potential drawbacks include the risk of psychoactive effects, dependency on long-term use, and varying legal status. However, these can often come with side effects like gastrointestinal issues, increased risk of infections, and potential organ damage with long-term use. However, limitations have potential side effects, the risk of dependency with long-term use, and the varying legal status of Delta 9 THC. This article aims to provide a comprehensive overview of Delta 9 Gummies, their role in inflammation management, and how they compare to traditional treatments. One alternative that has garnered attention is Delta 9 Gummies, a cannabinoid therapy that offers potential benefits for managing inflammation. In addition, it was shown that CBD is a negative allosteric modulator of the CB1 receptor . Thus, the action of CBD as a phytocannabinoid may support the biological activity of the endocannabinoid system. Various cell metabolic systems, including the endocannabinoid system, are involved in the regulation of redox balance. Additionally, CBD caused a reduction in the level of PUFA cyclization products, such as isoprostanes, in the cortex of transgenic mice (APPswe/PS1ΔE9) with Alzheimer’s disease . The resulting changes in the protein structures cause disruption of their biological properties and, as in the case of lipid modification, affect cell metabolism, including signal transduction 46,50. Moreover, the same study revealed no significant effect of CBD in hyperalgesia reduction, although an analgesic trend was observed . Similar results were obtained in the Δ9-THC and morphine gelatine groups; however, tolerance to morphine developed after one week of treatment, which was not observed after CBD or Δ9-THC treatment. Neuropathic pain is persistent and difficult to relieve; therefore, identification of novel, more effective therapeutic strategies is needed. Moreover, studies by Juknat et al. revealed that nuclear factor erythroid-derived 2-like 2 (Nrf2) was responsible for CBD-mediated modulation of inflammatory gene expression patterns in activated microglia cells . One of the more important targets of CBD is the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ), especially in the context of inflammation. On the other hand, CBD is also a positive allosteric modulator in micromolar concentration ranges for anionic ligand-gated ion channels, such as GABAA and glycine receptors (GlyRs) . Transient receptor potential (TRP) channels are a group of cationic ion channels primarily localized on the plasma membrane of numerous animal cell types. As with any treatment, it's important to weigh the potential benefits against the risks and to consult with a healthcare professional before use. Traditional treatments for inflammation often involve non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and other medications. Bag of CBD gummies consumed by patient marketed as a healthy solution for pain relief. Continued research is needed in this area, especially within disease states in which patients use concomitant medications (e.g., Parkinson’s disease, pain/inflammation, etc.) to determine the safety of CBD as a treatment option. Patient Global Impression of Change to evaluate perception of cannabidiol’s (CBD) effect on pain intensity, physical function, and sleep based on type of arthritis For this question, participants could “check all that apply.” On the basis of the distribution, many patients had pain in multiple joints. Most participants who completed the survey had tried CBD for symptomatic relief of arthritis (70%). Numerical Rating Pain Scale point reduction and percent pain reduction were evaluated among arthritis groups with nonparametric Kruskal–Wallis tests. Inclusion criteria included participants ≥18 years old and those with a prior diagnosis of arthritis as a cause of joint pain. There is no cure for this disease, and current therapy includes maintaining joint functionality through rehabilitation and losing weight, with pain alleviation using nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids in more severe cases. Administration of CBDA prior to carrageenan produced dose-dependent anti-hyperalgesia and anti-inflammatory effects. In another study, inflammatory pain was induced by carrageenan injection, and the effect of cannabidiolic acid (CBDA), CBD and Δ9-THC were investigated. In summary, CBD demonstrates anti-inflammatory activity and antioxidant effects by activating PPARs, either directly or indirectly. In addition, CBD anti-inflammatory activity has been shown to be antagonized by both a selective CB2 antagonist and AEA, an endogenous CB2 receptor agonist . CBD has recently been shown to modulate the endocannabinoid system activity by increasing anandamide (AEA) levels , which can affect cannabinoids signaling, including their interaction on cannabinoid receptors . Though it's often well-tolerated, CBD can cause side effects, such as dry mouth, diarrhea, reduced appetite, drowsiness and fatigue.In this trial, 27 healthy volunteers received either oral CBD (300 mg dissolved in corn oil) or placebo.Materials include a table summarizing results regarding CBD’s action in pain research and a CSV table containing CBD’s pharmacological data.FOCL is one of the most reputable brands offering premium quality CBD and THC products to boost mood, enhance focus, promote calm, and even improve sexual performance.Understanding potential risks and benefits can help ensure the safe and effective usage of CBD gummies for pain and inflammation relief.Finding the best CBD gummies for pain relief involves balancing potency, spectrum type, and quality.Osteoarthritis (OA) is a degenerative joint disease primarily affecting people over 60 years old.Researchers are continuously studying the long-term risks of CBD at various dosages.One of the biggest health benefits of CBD is that it provides pain relief without the risk of addiction. Our natural relief solutions use premium hemp-extracted CBD alongside other helpful ingredients. Pediatric use should be under professional supervision and with pediatric-formulated products. Yes—brands like Peace Naturals and Fab CBD offer arthritis-targeted blends combining CBD with turmeric and boswellia. Full-spectrum gummies contain trace THC ( Typically 30–90 minutes after ingestion, with peak effects around 2 hours. Factors to Consider When Choosing the Right CBD for Pain Wherever the movement goes, the company’s gummies are a bit pricier than some of the competition, but they also have 0% THC and are kosher and vegan. All of the company’s products come with a QR code to check third-party test results, and CBDistillery also is compliant with ISO 9001, Natural Farming Practice, Lab Tested Potency & Purity, and the U.S. That’s part of the pitch of CBDistillery’s broad spectrum CBD gummies, which pack 30mg of Cannabidiol per serving. Understanding the recommended dosage and proper usage of CBD gummies is crucial when seeking pain and inflammation relief. By incorporating CBD gummies into pain management routines, individuals may experience relief from pain and inflammation without solely relying on traditional pharmaceuticals. CBD gummies are gaining popularity as an alternative treatment option for pain and inflammation. We've also compared Delta 9 Gummies with traditional inflammation treatments and provided guidelines on how to use them effectively. In this article, we've delved into the intriguing world of Delta 9 Gummies and their potential role in managing inflammation. This approach, often called "start low and go slow," helps minimize potential side effects and allows for personalized dosing. When using Delta 9 Gummies for inflammation, starting with a low dose is important and gradually increasing until the desired effects are achieved. Therefore, this compound is suggested for use when therapeutic antiepileptic activities are needed. Considering the fact that modifications to the CBD structure may result in an improved therapeutic profile and biological activity, natural CBD derivatives are sought and their therapeutic utility is being evaluated. Due to the range of CBD metabolic effects known to date, interest in the possibility of using this phytocannabinoid is constantly growing. They are expressed in various cell types, participate in numerous physiological and pathological processes and also regulate inflammatory processes . In addition, CBD can induce the 5-HT1A receptor indirectly by increasing the level of AEA . Formulated with a blend of CBD, CBG, and turmeric, these gummies promote recovery and provide relief from aches and pains. Budpop CBD gummies are a popular and effective choice for relieving pain and inflammation. Notably, they use pectin instead of gelatin, reflecting cbdMD’s commitment to high-quality CBD products. With high-quality ingredients and a reputation for delivering results, Otterspace remains a top-rated brand in the realm of pain and inflammation relief. Delta 9 Gummies, on the other hand, are generally well-tolerated and may offer a more natural alternative for managing inflammation. Prescription medications and over-the-counter options, such as NSAIDs and corticosteroids, are commonly used to manage inflammation. However, more research is needed to fully understand the extent of these effects and the optimal dosage and administration methods. As for safety, while Delta 9 THC is generally well-tolerated, it can cause side effects such as dry mouth, changes in appetite, and psychoactive effects. These gummies are consumed orally and offer a discreet and convenient way to consume Delta 9 THC. Acute CBD treatment may not be sufficient to combat the cause of the pain and provide an effect lasting up to several hours (depending on the disease model, dose and route of administration). Chronic CBD treatment allows for long-term therapeutic effects to be achieved, without significant side effects or tolerance development. Animal studies with chronic CBD treatment last several weeks, up to several months, which may reflect the prolonged use in people, but the differences could not be excluded. People turn to CBD for all sorts of reasons—whether it’s to ease chronic pain, calm anxiety, or simply get a better night’s sleep. DiamondCBD has made a name for itself by offering high-quality, lab-tested products. It doesn’t make you drowsy or anything, it just takes the pain away with a nice little massage while rubbing it in! Charlotte’s Web – CBD Lemon Calm Gummy Another study in The Journal of Pain found that cannabidiol CBD not only reduced chronic pain but also helped improve sleep—something anyone dealing with pain can appreciate . What makes CBD special is how it interacts with other receptors in your body, too. It doesn’t just mask pain; it helps your body manage it better by targeting inflammation and calming your nervous system. CBD has become a go-to for pain relief because of the unique way it works with your body. Moreover, this article describes the detailed analgesic and anti-inflammatory effects of CBD in various models, including neuropathic pain, inflammatory pain, osteoarthritis and others. Despite extensive research into the biological effects of synthetic CBD derivatives, they have not been evaluated for their interaction with TRPV1, 5-HT1A and adenosine A2A receptors in the context of anti-inflammatory and antioxidant activity. Delta 9 Gummies, with their potential anti-inflammatory effects and additional benefits, present a promising alternative to traditional treatments. Studies have shown that cannabinoids like Delta 9 THC can have anti-inflammatory effects, potentially making them helpful in managing conditions characterized by inflammation. In a study of non-treatment-seeking healthy cannabis smokers, acute pretreatment with oral CBD (200, 400, or 800 mg) did not alter cannabis self-administration, cannabis-induced subjective drug effects including reinforcing effects (e.g., “high,” “good effect”), or cardiovascular effects relative to placebo . Strains like ACDC, Charlotte’s Web, and Harlequin are popular for pain relief due to their high CBD and low THC content. These strains are known for their calming effects and ability to ease inflammation without causing a high. Certain CBD-dominant strains are particularly effective for pain relief. Studies have shown that CBD can help with chronic pain, arthritis, neuropathy, and even migraines. Lichtman et al. proved that U.S. patients (but not patients from the rest of the world) experienced significant benefits from Nabiximols in cancer-related attenuation of pain. Clinical studies have demonstrated its efficacy in pain attenuation in several diseases. The majority of clinical studies describe the efficacy of CBD and Δ9-THC co-administration, generally in doses of 2.5 mg CBD and 2.7 mg Δ9-THC in an oral mucosa spray, with treatment periods varying from one to several weeks. To complicate the issue even further, it is known that partial agonist action is dependent on receptor expression, density, and tonic activity of the system; therefore, it may vary in different tissues and under different conditions , further supporting our state-dependent hypothesis. CBD may act as an indirect agonist of cannabinoid receptors through increased endocannabinoid tone , most likely through FABP inhibition 43,44, but on the other hand, it can directly antagonize the CB1 receptor . However, it is unknown what effects will be caused by “CBD gummies” or “CBD water”, which are increasingly offered by manufactures to a wide audience. Human CBD short-term studies illustrate low toxicity and mild adverse effects. It probably goes without saying that CBD gummies aren’t the same as the gummy worms you loved when you were a kid. While CBD is definitely soaring in popularity, research into its effectiveness is still somewhat in its infancy, and much more work is needed in order to determine precisely which health benefits it may have. Perhaps the most well-known use of CBD has been in the treatment of severe forms of pediatric epilepsy. Far from being a narcotic, the plant has been used for eons as a source of oil, fabrics, and medicine, long before anyone had heard of CBD gummies. One of the most common reasons people try CBD gummies is to improve their sleep. The gummies have a unique soft and yielding texture, so you can discreetly and quickly eat one when you need to. If your shoulders are up to your ears and your jaw is clenched most days, you can try taking two or three gummies for a higher dose. For anyone just stepping into the world of cannabis gummies, I think the CBDfx Original Mixed Berry CBD Gummies are a stellar place to start. Food and Drug Administration (FDA), positive public perception has led to an increase in the utilization of CBD as a treatment option for various medical conditions. This growing body of literature is beginning to indicate that cannabinoids target the ECS within arthritic joints and may confer mediation to arthritic and inflammatory joint disease (Richardson et al., 2008). Statistical analysis was performed to determine differences between types of arthritis and improvements in quality-of-life symptoms. FOCL Feel Good Gummies are an all-around choice that can help with everything from pain to just making your day a bit brighter. In this article, we’ll share the best CBD for pain that can help you out after a tiring day of physical work. To date, the consumer CBD market has far outpaced science, and well-designed, appropriately controlled, clinical trials and human laboratory studies are needed to definitively support or refute CBD’s therapeutic utility for many disease states. In vivo studies have revealed significant roles of various molecular targets in different models, namely, 5HT1a, CB1, CB2, TRPV1, α3 GlyRs, adenosine A1 and TRPA1. Due to its complex pharmacological profile, effects observed from CBD administration vary and might be state-dependent. CBD is a substance of great therapeutic potential but is currently very understudied. Despite the fact that there are trials on heathy volunteers that demonstrate CBD’s safety and good tolerance, these studies do not examine prolonged use, which is common in chronically ill people. Regardless of the cause and disease pathogenesis, patients with arthritis are subject to chronic pain, joint degeneration, and articular neuropathy, for which there are few viable long-term treatment options without significant side effects. In arthritic in vitro studies, CBD promoted chondrocyte and synoviocyte apoptosis but with stronger effects on the inflammatory-activated cells, which may be a positive result that indicates anti-arthritic activity 89,90. The effect was enhanced by TNFα pretreatment, which may suggest that CBD preferentially targets pro-inflammatory (activated) synovial fibroblasts, suggesting potential anti-arthritic activity . In several inflammatory-induced chronic pain models, cannabinoids, including CBD, may exert an analgesic and anti-inflammatory effects. Similarly, the (+)-8,9-dihydro-7-hydroxy-CBD derivative (HU-465), which has anti-inflammatory activity, especially at higher concentrations, binds to both CB1 and CB2 receptors, while its (−) enantiomer, (−)-8,9-dihydro-7-hydroxy-CBD (HU-446) has negligible affinity for both CB1 and CB2 receptors (Table 2). CBDV has been found to have antagonistic effects on GPR55 (Table 2), which probably leads to anticonvulsant effects . It has been suggested that its action may be due to a weak affinity for CB1 and CB2 receptors (Table 2) . Cannabidiolic acid (CBDA), being a C3′-carboxyl derivative of CBD (2,4-dihydroxy-3-(1R, 6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-alpha-6-pentylbenzoic acid), acts as a selective COX2 and prostaglandin endoperoxide synthase inhibitor and exhibits anti-inflammatory properties in human breast cancer cells . Therefore, known or potential effects of naturally occurring CBD derivatives are presented. It was also shown that A2A receptors can form heteromers with CB1 receptors in CA1 neurons and in the hippocampus of C57BL/6J mice . In another study, healthy volunteers ingested CBD (300, 600, or 900 mg) or placebo prior to being exposed to various visual stimuli, both positive and negative. Healthy controls were also recruited and used as a comparator to SAD patients, but did not receive CBD treatment. In another study, healthy adults were given oral CBD (100, 300, or 900 mg) before completing a slightly different public speaking task (the test of public speaking in a real situation, TPSRS) and subjective anxiety as well as physiological indices of anxiety (i.e., heart rate or blood pressure) were evaluated. In studies with healthy volunteers (i.e., without clinical anxiety), oral administration of CBD prior to the SPS has decreased self-reported ratings of anxiety relative to placebo. However, both HU-465 and HU-446 have been found to exhibit anti-inflammatory activity by inhibiting the release of IL-17 in mouse encephalitogenic T cells (TMOG) . It has been shown that both the naturally occurring (−)-CBD enantiomer and its synthetic derivatives (−)-7-hydroxy-5′-dimethylheptyl-CBD, and (−)-1-COOH-5′-dimethylheptyl-CBD have weak affinity for the CB1 and CB2 cannabinoid receptors (Table 2). It has been shown that another CBD derivative, cannabigerol (CBG; (2-(2E)-3,7-dimethylocta-2,6-dienyl-5-pentylbenzene-1,3-diol), a naturally open analogue of cyclohexenyl CBD, activates TRPV1 as well as 5-HT1A (Table 2) and has antidepressant and anti-inflammatory effects in intestinal diseases 2,72,118. It is also known that TRPV1 receptor activity is deeply involved in oxidative stress and inflammation . Therefore, CBD can modify the functioning of the entire heteromer, and thus modulate the activation of two groups of receptors involved in the regulation of redox balance and inflammation. Please do not use CBD/THC products if you are pregnant or nursing without consulting with your physician. CBD gummies take time to build up in your system and work best when taken consistently. Indulge in delicious, convenient gummies to support your body’s natural response to occasional discomfort, maintain daily mobility, and promote a sense of overall wellness. Welcome to the fascinating world of Delta 9 Gummies, a potential game-changer in the battle against anxiety. Marketing efforts have largely contributed to the rising popularity of CBD, and it has been touted as a treatment for numerous ailments. Logistic regression to analyze the effect of variables for those who selected yes for the question “Did you reduce or discontinue the use of other pharmacologic treatment modalities? Considering these findings, we performed a logistic regression analysis controlling for age and gender to determine the influence of arthritis diagnosis and the frequency and length of CBD use on the reduction/cessation of other medications. As an added bonus, the gummies come in delicious blood orange and sour raspberry flavors – so be careful with your dosage!Furthermore, pro-inflammatory factors (Calcitonin gene-related peptide or OX42) were reduced in spinal cord and dorsal root ganglia (TNFα) .Begin with a low dosage and gradually increase it until you achieve the desired effects while monitoring any potential side effects.In addition, it belongs to a group of compounds with anxiolytic, antidepressant, antipsychotic, and anticonvulsant properties, among others .CBD, depending on the concentration, can activate, antagonize or inhibit cannabinoid receptors (CB1 and CB2), as well as ionotropic (TRP) and nuclear (PPAR) receptors (Figure 4) 52,59,60.The magnitude of pain alleviation in our study participants, as measured by percentage reduction in pain or point difference, both surpass the clinically important differences reported in literature (2-point reduction or 30% reduction in pain, respectively) (Farrar et al., 2001, Salaffi et al., 2004). As the name suggests, Absolute Nature is all about providing 100% organic and natural CBD products for your overall wellness. First time trying a CBD product and I’m very happy with Absolute Nature CBD gummies. All of their products are made using hemp that is grown organically in Colorado, without any pesticides. As for safety, while Delta 9 THC is generally well-tolerated, it can cause side effects such as dry mouth, changes in appetite, and psychoactive effects.The same effect was seen in the in vitro cellular model of neurological inflammation (BV2 cells exposed to LPS and M-213 cells treated with media prepared from BV2 cells exposed to LPS) .Physical exam showed an obese man in no acute distress with a depressed level of consciousness but who awoke to painful stimuli.Therefore, Δ9-THC has been a natural subject of thousands of studies concerning pharmacology, toxicity and the therapeutic potential of cannabinoids in the intervening years.GPCRs and transporter proteins are less abundant targets of CBD, and there are only two different targets that are nuclear receptors.For example, 4-hydroxynonenal (4-HNE) has been identified as a stimulator of the cytoprotective transcription factor Nrf2, an inhibitor of antioxidant enzymes (e.g., catalase and thioredoxin reductase) and a pro-inflammatory factor acting through the NFκB pathway .CBD has been shown to affect redox balance by modifying the level and activity of both oxidants and antioxidants (Figure 2 and Figure 3). To enhance absorption and reduce the risk of gastrointestinal discomfort, take CBD gummies with food. It’s also essential to keep track of your overall daily CBD intake, especially if you are using other CBD products like tinctures, to avoid exceeding recommended limits. Considering the strength of each gummy is crucial when determining the dosage, as some products may have lower CBD content per gummy, while others may contain higher doses, up to 25mg or more. The CBD product industry has experienced tremendous growth, in part, because CBD is widely touted as an effective therapeutic for myriad health conditions. Global policy changes have increased access to products containing cannabidiol (CBD), a primary constituent of hemp and cannabis. The information presented should not be considered a comprehensive source and must not be utilized to make decisions related to health or well-being. When choosing CBD gummies, prioritize quality, potency, and adherence to legal regulations in your state. Look for current lab results on company websites or product packaging to ensure accurate THC quantities and verify safety standards were met during production processes. Best CBD Gummy For Sleep: Deep Zzzs CBD CBN THC Gummies While these treatments can be effective, they also come with potential side effects, such as gastrointestinal issues and increased risk of infections.It has been shown that another CBD derivative, cannabigerol (CBG; (2-(2E)-3,7-dimethylocta-2,6-dienyl-5-pentylbenzene-1,3-diol), a naturally open analogue of cyclohexenyl CBD, activates TRPV1 as well as 5-HT1A (Table 2) and has antidepressant and anti-inflammatory effects in intestinal diseases 2,72,118.|}Initial clinical evidence suggests that CBD possesses a desirable safety profile , while numerous preclinical findings present anti-inflammatory effects of CBD 8,9,10,11,12.In a study of non-treatment-seeking healthy cannabis smokers, acute pretreatment with oral CBD (200, 400, or 800 mg) did not alter cannabis self-administration, cannabis-induced subjective drug effects including reinforcing effects (e.g., “high,” “good effect”), or cardiovascular effects relative to placebo .Studies have shown that CBD can help with chronic pain, arthritis, neuropathy, and even migraines.Background questions included demographic information, characteristics of CBD use, and previous treatment modalities.Numerous targets among ion channels and ionotropic receptors might explain CBD’s efficacy as a seizure controlling drug, but they may also contribute to the anti-nociceptive action of CBD.It might seem silly, but these gummies are particularly appealing because they’re shaped like gummy bears! “Calm” is one of three different gummies made by the brand (along with “Sleep” and “Recovery”) and it contains 75mg of lemon balm per serving, along with terpenes and flavonoids. While Charlotte’s Web made a name for itself largely for the way its products have helped children coping with severe forms of epilepsy, their CBD products are popular with all types of consumers. The gummies are absolutely THC-free and each batch is tested by independent third-party labs, with a “click here to view lab results” right there on the website. However, the efficacy of CBD as a sole treatment for most of the other indications discussed in this review remains unclear due to various reasons. HDL-cholesterol concentrations (primary trial endpoint) did not differ following CBD treatment relative to baseline . Oral CBD (100 mg, twice daily for 16 weeks) or placebo was administered to 62 patients with type 2 diabetes (noninsulin treated). Begin with a low dosage and gradually increase it until you achieve the desired effects while monitoring any potential side effects. Reading feedback from other users who have tried different brands and products can give you a better understanding of their effects, taste, dosage, and overall satisfaction. Before making any changes to your dosage, consult with a healthcare professional. The fact that CBD offers natural stress relief without causing psychoactive effects makes it an appealing option for many individuals seeking anxiety relief. When it comes to broad-spectrum pain relief, Soul CBD Gummies are the top choice. Fourth, patients submitted subjective reports of their symptoms, and the survey was not distributed in a controlled manner immediately after CBD use, making the results susceptible to recall bias. Second, the study population was a self-selected sampling of convenience and hence might not be representative of the general population. First, the survey used was created by the authors and was based on clinical expertise as well as other published studies (Corroon and Phillips, 2018, Bhamra et al. 2021, Moltke et al, Schilling et al. 2021, Moeller-Bertram et al. 2019, Devitt 2019). The study has limitations that must be considered when interpreting these results. It is also important to remember that there are few to no studies on chronic CBD administration in healthy people. However, some studies indicate no modulation of Δ9-THC’s effects by CBD . In the majority of animal studies, CBD has been demonstrated to exert analgesic effects, diminishing hyperalgesia and mechanical/thermal allodynia through various routes of administration. Enter CBD gummies, a convenient and discreet way to harness the therapeutic potential of cannabidiol. Lastly, a large proportion of patients did not know the type of CBD product (e.g., isolate, broad spectrum, full spectrum) they consumed, and therefore, the authors were unable to evaluate associations between patient-perceived effects of CBD and product type. Designing a prospective study may allow assessment of pain before and after CBD use in real time to circumvent recall bias limitation. This extra-strength version offers a significant boost compared to their standard gummies. Sunday Scaries Extra Strength CBD Gummies are highly favored by those seeking potent stress relief. Free from animal by-products, artificial colors, and flavors, they are ideal for individuals with common allergens, such as peanuts, shellfish, and gluten. With 100mg of CBD per gummy, these gluten-free and vegan gummies deliver a potent dose. Derived from the plant’s flower, the gummies boast higher cannabinoid and terpene content. The data presented herein unravel what is known about CBD’s pharmacodynamics and analgesic effects to provide the reader with current state-of-art knowledge regarding CBD’s action and future perspectives for research. Therefore, we review the basic research regarding molecular mechanism of CBD’s action with particular focus on its analgesic potential. However, data regarding CBD’s mechanism of action and therapeutic potential are abundant and omnifarious. Regardless of the direct effect of CBD on TRP receptors, increasing the level of AEA, as a full TRPV1 agonist, also affects the activation of TRP receptors and negatively regulates the 2-arachidonoylglycerol (2-AG) metabolism . It has been suggested that there is a relationship between molecular signaling of TRPV1 and oxidative stress because ROS and lipid peroxidation products can regulate the physiological activity of TRPV1 by oxidizing its thiol groups . CBD, as a TRPV1 receptor agonist, binds to it and causes desensitization, leading to “paradoxical analgesic activity” similar to that of capsaicin . This CBD oil tincture interacts with your endocannabinoid system to ease pain and speed up recovery — whether you’re dealing with that crushing back pain or something more severe.Clinical studies have demonstrated its efficacy in pain attenuation in several diseases.These targets were often not replicated throughout various models, suggesting the hypothesis of state-dependent effects of CBD.As more studies are conducted, and our understanding of the endocannabinoid system deepens, we may see Delta 9 Gummies becoming a more mainstream option for managing inflammation.We compared demographics by type of arthritis and found a significant difference in age (P2).However, both HU-465 and HU-446 have been found to exhibit anti-inflammatory activity by inhibiting the release of IL-17 in mouse encephalitogenic T cells (TMOG) .With its 90-day satisfaction guarantee, you can try its products risk-free.With its personalized dosage, you can take gummies according to your chronic pain level.However, it’s essential to check the specific laws in your state before purchasing any CBD products. 6. PPARγ Receptor Direct antioxidant effects of CBD (closed arrows indicate reducing effects; opened arrows indicate inducing action). The free radicals produced in these reactions are characterized by many resonance structures in which unpaired electrons are mainly found on the phenolic structure, suggesting that the hydroxyl groups of the phenol ring are mainly responsible for CBD antioxidant activity . CBD has been shown to affect redox balance by modifying the level and activity of both oxidants and antioxidants (Figure 2 and Figure 3). CBD has potential antioxidant properties because its free cationic radicals exhibit several resonance structures in which unpaired electrons are distributed mainly on ether and alkyl moieties, as well as on the benzene ring . Moreover, CBD has the potential to act in an anti-inflammatory way; however; the effects are unclear. The effect of CBD was blocked by a 5HT1a receptor antagonist, WAY100635, in wild-type mice, indicating the involvement of 5-HT1a and CB2 receptors in analgesic and anti-inflammatory actions . Preclinical and clinical studies suggest a potential anti-nociceptive effect of CBD and CBD combined with other compounds in several pain-related diseases. We also analyzed the number of possible interactions with transmembrane receptors in relation to possible outcomes on cell membrane potential and cellular activity. High activity for ionotropic receptors is a significant contributor to the physiological effects of CBD. One important consideration is that patients who reduce or stop other medications may also be more likely to use CBD regularly and for longer durations as a replacement for the alternative medications. Similarly, patients taking CBD for a period of more than three years were 3.6 times more likely to reduce or cease other medications, when compared to those taking CBD for less than 30 days. When controlling for age, dose, gender, the type of arthritis was not found to be an independent predictor. Cannabinoids have been shown effective in human trials for chronic pain (Campbell et al., 2018; Moeller-Bertram et al., 2019; Wiese & Wilson-Poe, 2018). Can be defined as macroscopic fungi, used in the form of extracts or powder which may support prevention, alleviation or healing of multiple illnesses, and/or lend balance to a healthy diet. One of more than 120 cannabinoids found in cannabis that may support relief from cancer, depression and bacterial infections. Neither these products nor these statements have been evaluated by the Food and Drug Administration, and the safety of these products have not yet been determined. A physician’s advice should be sought before using these products and any supplemental dietary product. The glassy texture has a silkier feel than gummies coated in sugar. These have a mellow green apple flavor that stands out from other cannabis gummies. It’s one of the top CBD gummies for workdays, even though it’s a CBG gummy. The rich, fruity profile only makes it easier to block pain by indulging in a few of these throughout the day. In our cohort, 8.6% of patients reduced and 18.9% discontinued the use of opioids. A large meta-analysis found only a minimal pain reduction for topical NSAIDs versus placebo and importantly it was noted that at no time point did topical NSAIDs reach the MCID (Zeng et al., 2018). The use of topical NSAIDs has also been studied as an alternative to oral NSAIDs, due to the unwanted systemic side effects of the latter. The discussed studies indicate a positive influence of CBD on various diseases; nevertheless, animal studies cannot always be translated into human results. More detailed research is needed to clarify this effect; however, the inflammatory state is not always negative. When co-administered with Δ9-THC, CBD may reduce the effective dose and diminish negative side effects of Δ9-THC 68,74. In turn, Lynch et al. did not observe a significant reduction in pain intensity in chemotherapy-induced neuropathic pain compared to placebo. CBD administration produced an anti-allodynic effect in the Von Frey test. Administration of CBD also attenuated neuropathic pain and inhibited elevation of microglial density and phosphorylated p38 mitogen-activated protein kinases . Moreover, Pan et al. demonstrated that CBD prevents cisplatin-induced oxidative/nitrosative stress, inflammation and cell death in the kidney and improves renal function . The data presented herein unravel what is known about CBD’s pharmacodynamics and analgesic effects to provide readers with current state-of-art knowledge regarding CBD’s action and future perspectives for research. Therefore, we review the basic research regarding the molecular mechanisms of CBD’s actions with particular focus on its analgesic potential. However, data regarding its mechanism of action and therapeutic potential are abundant and omnifarious. We focus on studies which entailed administration of CBD alone and thus do not include studies featuring co-administration of CBD and THC (e.g., trials involving nabiximols/sativex). In the U.S., this problem came to a head in 2019 when the FDA sent warning letters to 15 companies for making unsubstantiated therapeutic claims about CBD in violation of the U.S. Food and Drug Administration (FDA); this product is approved for the treatment of rare pediatric seizure disorders. The CBD product industry has experienced this tremendous growth because CBD is widely touted as an effective therapeutic for myriad health conditions. FAB CBD chews are refreshing, all-natural CBD isolate chews that include cannabinoids, terpenes, and flavonoids which are often left out in isolated products. As an added bonus, the gummies come in delicious blood orange and sour raspberry flavors – so be careful with your dosage! The low dose of THC contributes anti-stress and relaxation properties that complement the other ingredients, creating a harmonious entourage effect. Best sleep in a while and pains are minimized. Of the respondents, 176 (30%) patients with arthritis had not tried CBD, whereas 428 (70%) endorsed CBD use. Despite all of the study participants having a diagnosis that was made by a physician, only 45.6% had spoken to a health care professional about CBD use for their condition. Between the different arthritis types, a larger percentage of patients with osteoarthritis (66.2%) reported reductions in other medications used compared to RA (56.3%) and autoimmune arthritis (53.7%). This effect was absent in sigma-1 receptor (σ1R) knock-out mice and was reduced by the σ1R agonists PRE084 and PPCC . Systemic (i.p.) injection of CBD reduced mechanical allodynia and reversed conditional place preference produced by peripheral nerve block in a rat model of incision pain. Furthermore, pro-inflammatory factors (Calcitonin gene-related peptide or OX42) were reduced in spinal cord and dorsal root ganglia (TNFα) . In a rat complete Freund’s adjuvant-induced monoarthritic knee joint model, transdermal CBD gel applied for 4 days dose-dependently reduced joint swelling, limb posture scores, synovial membrane thickening and animals’ pain. CBD administration prevented joint pain development and exerted a neuroprotective effect . As the company mission puts it, they’re devoted to developing “premium CBD products through innovation and excellence, with service to match.” I like the taste, the look and feel of the products and all of the amazing reading material on their website. The fruit flavor gummies, which are made with natural fruit juices, are not only vegan and USDA Organic certified but also contain non-GMO hemp. These full spectrum CBD fruit gummies offer an easy way to get your daily dose of CBD in a way that you can measure. In one animal study, Ignatowska-Jankowska et al. demonstrated that repeated CBD treatment may inhibit specific immunity by reducing T, B, T cytotoxic, and T helper cell numbers, while increasing the number of NK and NKT cells involved in nonspecific antiviral and antitumor immune response . Patients suffering from chronic pain are often forced to take medications continuously for many years; it is not possible to test the effects of CBD on healthy people for such a long time 123,124. In the inflammatory-related pain modes, some research gives hope for an anti-inflammatory action of CBD, while others have reported opposing results. CBD is a well-tolerated and safe natural compound exerting analgesic effects in various animal models of pain, as well as clinical studies. It was proven to mitigate neuropathic pain and improve quality of life in patients suffering from several diseases, e.g., multiple sclerosis, cancer or rheumatoid arthritis 116,117,118,119. Here, we review the main biological effects of CBD, and its synthetic derivatives, focusing on the cellular, antioxidant, and anti-inflammatory properties of CBD. The chemistry and pharmacology of CBD, as well as various molecular targets, including cannabinoid receptors and other components of the endocannabinoid system with which it interacts, have been extensively studied. It’s hard to say, but cbdMD’s gummies are a good option for people who would like the option to try three different dosage strengths, a variety of flavors, and cannabinoids such as CBG and CBN, and terpenes. But SOUL’s CBD gummies come in a range of yummy flavors, including strawberry, passion fruit, and pina colada, to name a few. Otterspace CBD Gummies are also well-liked by customers seeking a tasty, non-psychoactive option for pain management. Opt for a product with the right CBD concentration to achieve effective relief without overdoing it. Cheef Botanicals, on the other hand, offers vegan-friendly CBD gummies made from all-natural ingredients.