A study comparing the effect of synthetic THC (nabilone) versus amitriptyline on sleep in fibromyalgia patients with chronic insomnia demonstrated superiority of nabilone over amitriptyline in insomnia severity index and some improvement in restfulness . The knowledge of the effects of cannabinoids on serotonin receptor–mediated respiratory regulation supports their potential role in sleep apneas (both central and obstructive). In summary, most of these studies evaluating effects of cannabis and cannabinoids are limited by differences in study designs, sample sizes, and procedures, as well as the ratios of THC to CBD used. This review aims to summarize the modulatory effects of cannabinoids on sleep physiology and provide a critical evaluation of the research on their potential therapeutic benefit in various sleep disorders. Table 4 illustrates JBI as a quality assessment tool for case reports. AMSTAR is utilized to assess the eligibility of three systematic reviews shown in Table 3. Two do not have full texts, and one is an animal study, hence excluded. Five databases (PubMed, PubMed Central, Medline, Cochrane Library, and ScienceDirect) were used to identify publications included in the review. Studies with no available full text were also excluded from the review. Further, administration of 2-AG in animals has been shown to augment slow wave sleep (SWS) and reduce paradoxical sleep (PS) when administered before the dark phase. At this time, there are a lack of human studies collaborating these findings. Studies in rats injected with increasing dosages of CBD showed an increase in total percentage of sleep, with a decrease in REM latency at lower doses and an increase in REM latency at higher doses 40, 41. Plus, it’s made with organic hemp that’s grown by the company themselves. The hemp is grown in the US on the brand’s own certified organic farm in New York. In this article, I’ve combined my personal experiences with my professional opinion to recommend the eight best CBD products for sleep. Discover the best CBD for sleep, selected by a functional nutritionist with the highest quality standards in mind. Nevertheless, future research assessing CBDs effectiveness in population of patients specifically with insomnia utilizing validated subjective and objective measures is necessary before definitive inferences can be made. Individuals receiving 20 mg CBN demonstrated reduced nighttime awakenings and overall sleep disturbance relative to placebo, with no impact on daytime fatigue. This was a double-blind, randomized, placebo-controlled study conducted between May and November 2022. RRG and NSM have also received investigational product and matched placebo from Teva Pharmaceutical in unrelated clinical trials. There is a clear need for further investigations on the safety and efficacy of cannabinoid therapies for treating sleep disorders using larger, rigorously controlled, longer-term trials. The content of CBD and timing of use showed that CBD with sedation effects (Indicas) is usually taken at night. The mixed (inhalation + non-inhalation) route is preferred (45% of respondents), and this is attributed to the tailored pain relief experienced . The primary endpoint is the improvement of the average pain Numerical Rating Score (NRS) from baseline. Chronic pain is persistent pain for more than or equal to three months in duration. Therefore, formulation of the safety standard used for CBD could be a possibility soon if the growing evidence from more studies points to the efficiency and safety of CBD. Recently, there has been increased interest in the use of cannabinoids primarily due to their neuromodulatory effect on the vagal nerve ganglion, as described above (and shown in Fig. 2). Multiple pharmacological agents have been investigated and found to have limited therapeutic potential. Central sleep apneas (CSAs) are caused by momentary failure of normal ventilatory rhythm during sleep. Some report improvement in sleep with CBD use, while others report increases in wakefulness 28, 93. Pharmacological management of RBD is mainly limited to agents like benzodiazepines as well as melatonin; there is continued interest in exploration of other potential agents for treatment. Rapid eye movement sleep behavior disorder (RBD) is a parasomnia caused by loss of atonia during REM sleep which leads to dream-enactment behaviors. Due to increased publicity on social media of the supposed benefits of this product, in addition to the lack of clear regulations, it is becoming a widely used treatment for sleep disorders. The jury is still out on what the best form and dosage is for sleep, so for now, follow the recommended guidelines on the bottle you are taking and be sure to confirm that the type you are using is legal in your area. Like many other natural sleep remedies, CBD appears to be the most effective for short-term use for some people. Before using any new supplement, be sure to speak with your healthcare provider about your particular situation and any current medications you may be taking. Practicing good sleep hygiene is an often overlooked lifestyle modification that can be extremely helpful for many people. Table 7. Summary table for the included Studies. However, the science of cannabinoids in various sleep disorders is still in infancy. Even with legalization in multiple states in the USA, cannabis is still considered a drug of high abuse potential by the DEA. Based on the limited available data on sleep disordered breathing, the American Academy of Sleep Medicine (AASM) has recommended against routine use of medical cannabis for OSA treatment . For sleep, short-term use has been shown to improve subjective and objective measures, but long-term effects are still unknown. The systematic review is according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 checklist. These questions include further elucidation of the dichotomy between the effects of THC and CBD, as well as identifying any long-term adverse effects of medicinal cannabinoid use. This review also identified several questions that should be addressed in future research. Sleep is often a secondary, rather than primary outcome in these studies. Articles chosen included randomized controlled trials and open label studies. Everyone has difficulty sleeping once in a while, but if your sleep troubles are interfering with your daily life, it’s time to check in with a healthcare provider. If real lavender essential oil is used, it can complement the CBD, helping to calm you down and promote better sleep. Generally, you can find oils and gummies that contain anywhere from 10 milligrams to 50 milligrams (or more) of CBD per serving. There’s not as much research on how the CBD in topicals affects sleep directly, but topicals can help with pain, which can indirectly improve sleep. They contain cannabidiol, as well as all the other cannabinoids, including a very small amount of THC. Cannabinoids could have a potential positive role due to their effect on the ECS and the limbic and paralimbic systems which decrease the activity of the amygdala and the hypothalamus yielding decreasing hypervigilance and hyperarousal . With their known anxiolytic role, cannabinoids remain of interest and have been under investigation for PTSD. In human studies, dronabinol has been shown to decrease Apnea-Hypopnea Index (AHI) and subjective sleepiness in a phase II placebo-controlled trial . Restless leg syndrome (RLS) is a sleep-related movement disorder accompanied by an unpleasant urge to move the legs, exacerbated by inactivity and relieved by movement, which can negatively affect sleep quality. In summary, scientists may be able to develop a medication or lifestyle modification/behavioral therapy for conditions like obesity by understanding the role of the endocannabinoid system and its interaction with circadian rhythms and sleep restriction. These findings coincided with increased desire for palatable food suggesting a role of the endocannabinoid system in excessive food intake during sleep debt . The system’s potential role in the regulation of the circadian rhythm has been linked to its effect on the suprachiasmatic nuclei via the CB1 receptor–related GABAergic effect 43, 44. If your sleeping difficulties are due to anxiety or pain, CBD may provide relief from your symptoms so you can fall asleep faster and stay asleep longer. Compared to other sleep aids, cannabidiol may be safer and more effective than prescription or over-the-counter options. Research16 has found that endocannabinoids may protect the brain from symptoms related to obstructive sleep apnea (OSA), a condition that causes abnormal patterns of breathing while asleep. Most studies have been limited by methodological heterogeneity as well as the use of variable dosages . Nabilone, a synthetic cannabinoid, has been studied for nightmares in PTSD patients. Its pathophysiology is linked to dysregulation of serotonin and noradrenaline as well as endogenous cannabinoids and opioids . Though anatomically rats exhibit central sleep apneas, these results can be interpreted in the context of OSA-related unstable respiratory patterns. Albeit with small studies (and limited power), there have been some preliminarily promising results. Medical Side Effects of CBD REM sleep is regulated by neurons present in the pons and hypothalamus and NREM sleep is regulated by neurons in the preoptic areas (like the ventrolateral preoptic nucleus) that inhibit the ascending arousal systems . The regulation of the sleep-wake cycle is a complex interplay between various neuroanatomical and neurochemical systems. An exception to this is the cannabis-derived compound dronabinol which is classified as schedule III . She is also currently taking a sleep science certification course. Regulations of cannabis products remain a challenge for most countries. CBD oils provide relief for various conditions, including pain without intoxication . People have more access to a wide variety of CBD products like cannabis flowers, tinctures, concentrates, topical lotion/creams, and edibles which are self-administered and with little or no supervision by a physician . It combines 200 milligrams of broad-spectrum CBD with organic lavender water and organic lavender oil, which are both well-studied for their sleep benefits. Our experts review the ingredients, effectiveness, side effects, price, and more to make sure that users find the highest quality products available. However, only 2 of the 34 studies focused on patients with insomnia, of which 1 study was a case report. This systematic review can benefit other researchers and even ordinary people eager to know the latest updates on CBD research on chronic pain. This systematic review aims to determine the status of the efficacy and safety of CBD on chronic pain. 1 with various hypothetical hypnograms depicting effect of cannabinoids on stages of sleep. A recent controlled trial did show increased sleepiness based on subjective assessment in subjects who used CBD-dominant cannabis, but it is unclear if this was due to the small amount of THC in it . Most of the studies examining these effects were polysomnography-based primarily done in the early 1970s. The two widely studied exogenous cannabinoids THC and CBD have different actions on the CB1 and CB2 receptors and thus different degrees of psychoactive effects (Table 1 compares the mechanism and effects of these two compounds). Some studies have also suggested the role of the endocannabinoid system in modulation of the serotonin system 22, 23. This roller has bergamot, lavender, and chamomile oils, all of which help improve sleep. Also, cbdMD sources their hemp from U.S. farmers, and every batch is third-party tested for potency and purity. This broad-spectrum tincture from cbdMD is a potent blend of multiple sleep-supporting ingredients. There is growing data on the use of these compounds for medicinal purposes, such as treatment of pain and chemotherapy-related side effects. Marijuana, or cannabis, is recognized as a schedule I drug by the US Drug Enforcement Agency (DEA) with high potential for abuse. Due to their psychotropic effects and somnolence, they have been frequently used for sleep induction and in conditions like post-traumatic stress disorder (PTSD)–related nightmares. Around 104 cannabinoids have been identified, out of which delta-tetra-hydrocannabinol (THC) and cannabidiol (CBD) have been most widely studied . Some studies showed promising evidence to support the safety of CBD. Rabgay et al. concluded that there is no sufficient evidence to fully establish CBD’s efficacy on pain. In addition, different routes of administration showed other forms of pain relief. These observations show that a variable amount of CBD exerts different effects on a healthy cell. Create a file for external citation management software There is a high price tag on good quality CBD available, and affordable CBD products are not 100% reliable due to some manufacturers' mislabeling issues about their exact content. With more states opening their doors to the medical benefit of CBD, the issue of obtaining good quality CBD poses a risk for those who want to use it as an alternative to their current pain medications . These studies highlighted different benefits of CBD on different areas of the body, making the potential value of the CBD product even greater. It also highlights the antinociceptive and anti-inflammatory effects of D8-THC, cannabidiol, derivative HU308, and the new racemic CB1 allosteric ligand . A COA is a report from a third-party lab that verifies purity and potency, as well as the specific dosage of CBD (and the other cannabinoids). The USP and NSF don’t oversee CBD products, so you’ll want to look for certifying agents that deal with CBD specifically. However, if you want to use CBD during the day too, you might not want too many relaxation-inducing ingredients, especially melatonin, because of the potential for drowsiness. Cannabidiol is available as a crystalline isolate, meaning it has been purified to contain only CBD, or as a full-spectrum oil containing a variety of compounds including cannabinoids, terpenes, and essential oils. In the United States, CBD in hemp oil is legal as long as it is derived from hemp and contains less than 0.3 percent THC.1 There’s been a lot of buzz about CBD and cannabis thanks to the passing of the 2018 Farm Bill1 that legalized hemp-derived CBD with less than 0.3 percent tetrahydrocannabinol (THC) at the federal level. More and more people are talking about taking CBD oil to help with sleep. Most studies are pre-clinical or have small sample sizes which limit their applicability. More studies and research are rolling in to provide evidence-based solutions to the current crisis. Therefore, there is fear on the patients’ part about CBD’s availability after research and the financial cost they would have. However, there is a challenge for patients to report the actual outcome observed because health insurance covers opioid medication but not CBD. Boehnke et al. reiterated in this study that subgroups in the sample population are essential in analyzing the results of CBD use . When it comes to sleep, CBD appears to work for short-term use and in higher doses. Other possible side effects include diarrhea, dry mouth, drowsiness, fatigue, and reduced appetite. One of the most common side effects is drowsiness, which could impact job performance and safety, and impair driving to and from your place of work. When shopping for CBD, you want to make sure you’re buying a quality product brand from a reputable brand. Of course, CBD products are also available online through many independent retailers. Since their widespread legalization in 2018, CBD products have been available far and wide. The Charlotte’s Web Lavender Hemp-Infused Roll On has only high-quality ingredients. In addition to the high-quality formulation, there’s a lot of good to say about the company itself, too. It has 1,500 milligrams of CBD per bottle, plus chamomile flower extract, hops flower extract, lemon balm extract, passion flower extract, valerian root extract, and melatonin. Most studies about CBD’s effect on sleep use doses that are dependent on body weight — typically 1 to 50 milligrams per kilogram35 . Third-party testing is vital to ensure you’re getting a quality CBD product, but testing hemp products isn’t as straightforward as other types of supplements. While all high-quality CBD oil may help with sleep in some way, you might also want to consider your (and the product’s) intended use. Another review found that CBD could improve overall sleep quality23, decrease sleep disturbances, and reduce the amount of time it takes to fall asleep. For starters, one study looked at how CBD affects sleep in people with insomnia. A PRISMA flow diagram 2020 was used to show the study’s inclusion and exclusion of articles found in the databases used. The review protocol can be acquired with a request addressed to the lead author. The PICO strategy was used to formulate the question of this review. This descriptive systematic review was done according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 checklist . Obstructive sleep apnea (OSA) is the most prevalent sleep-related breathing disorder in the USA . Further, in the absence of other robust clinical data, routine use cannot be recommended for RLS or PLMS at this time. Two case series, one including 6 patients and another with 12 patients have shown near total remission in RLS with recreational marijuana smoking 72, 73. THC alone has been shown to decrease sleep latency but with long-term use it can decrease total sleep, likely due to tolerance of effect . There is a dose-dependent effect on REM sleep latency—with higher doses causing an increase in latency while mid-range doses yield a decrease . MedTerra Isolate CBD Oil Myrcene has been found to have sedative effects and is also found in high levels in the sleep-inducing herb, hops (the same flower found in beer).10 This signaling is thought to influence the activity of various hormones, neurotransmitters, and other cells that affect things like the sleep-wake cycle, emotional regulation, and pain. Scientists are still researching exactly how cannabinoids improve sleep, but initial findings suggest that it has to do with how endocannabinoids interact with proteins, receptors, and chemicals in the brain. Walking into your local gas station or pet store, you’ll likely notice the wide range of CBD oil products available as pure oils, tinctures, gummies, vapors, and more. Aromatherapy has been shown to improve sleep quality20 and reduce pain, stress, anxiety, and depression. On top of that, Charlotte’s Web grows its own hemp on certified organic farms and has products certified by third-party testers. The Aspen Green Relief CBD cream combines 1,000 milligrams of organic full-spectrum hemp with a handful of other ingredients, both active and inactive. Research shows that lavender can improve sleep quality in those with10 and without insomnia11. This has been further explored in other rat studies utilizing CB receptor antagonists and cannabinoids, which suggest a role of CB1 and CB2 receptors in suppressing apneas (as shown through dronabinol) . In animal studies, cannabinoids have been shown to reduce apneas (primarily serotonin induced) when injected intraperitoneally in Sprague-Dawley rats; however, they may yield decreased REM sleep and sleep efficiency 75, 76. PSG data are lacking on the effects of cannabinoids on sleep-related movement disorders. In summary, the effect of cannabinoids on sleep and insomnia is not only dose dependent, but also heavily influenced by type and combinations used. CBD use has been shown to increase total sleep percentage with mid to high doses in rat models . Applicability is also limited due to lack of assessment of dose-related effects. Small human studies have been performed demonstrating improvement in OSA severity with administration of dronabinol 58, 59. In general, sleep apneas in an individual are usually a mix of both central and obstructive events. This review aims to summarize the modulatory effects of cannabinoids on sleep physiology and provide a critical evaluation of the research on their potential therapeutic benefit in various sleep disorders.MedTerra’s Isolate CBD Oil combines 99.6 percent U.S.-grown hemp with certified organic MCT oil.Due to their psychotropic effects and somnolence, they have been frequently used for sleep induction and in conditions like post-traumatic stress disorder (PTSD)–related nightmares.This ventilatory load is normally counteracted by compensatory mechanisms in the awake state but is delayed during sleep .The two widely studied exogenous cannabinoids THC and CBD have different actions on the CB1 and CB2 receptors and thus different degrees of psychoactive effects (Table 1 compares the mechanism and effects of these two compounds).It is suggested that CB1 receptors located in the pons and basal forebrain may be involved in sleep induction .Although CBD and THC come from the same cannabis plant and have almost identical chemical structures, they attach differently to a CB1 receptor, eliciting different effects.A crossover study with nabilone that evaluated various polysomnography (PSG) parameters demonstrated increased sleep efficiency and total sleep time, as well as decreased arousal index; however, there was increased sleep onset latency . The use of essential oils has been increasing in popularity, especially for sleep. Many authorities say dosing should be based on body weight, so speak to a healthcare provider with experience using medicinal cannabis about what dosage may be best for you. Unfortunately, there are still no widely accepted guidelines on the most optimal dosage for sleep, and concentrations can vary widely between products. Research on the most effective dosage for sleep has varied, but most studies have agreed that higher doses seem to work better.18 CBD and THC are cannabinoids that both come from the cannabis plant. Hence, there is a limitation in conducting studies on CBD products. In addition, good-quality and affordable CBD products should be available once everything is in place. However, more minor studies are focused on using pure CBD products, which are nonintoxicating. The outcome of each study mentioned above can set a new playing field for pharmaceutical companies for drug development to explore and investigate using clinical trials in a large sample population. CBD for pain relief still has a long way to be fully established, but the majority of studies possess promising outcomes. As this systematic review proceeded, challenges and questions about CBD use in chronic pain were revealed. In a similar cross-sectional survey with 1087 patients, Boehnke et al. determined the relationship between the route of administration, CBD content, and timing of use in managing chronic pain . In an RCT done by Lichtman et al., nabiximols (THC+CBD) oromucosal spray was used as an adjunct treatment in 291 patients with advanced cancer and chronic pain on opioids . Aspen Green Relief Full Spectrum CBD Cooling These observations show that a variable amount of CBD exerts different effects on a healthy cell.When it comes to sleep, CBD appears to work for short-term use and in higher doses.There is a dose-dependent effect on REM sleep latency—with higher doses causing an increase in latency while mid-range doses yield a decrease .Many authorities say dosing should be based on body weight, so speak to a healthcare provider with experience using medicinal cannabis about what dosage may be best for you.In the future, clinical trials should focus more on using pure CBD extract to treat chronic pain to attain evidence to properly recommend CBD in the health insurance sector so that patients may benefit to the full extent.CBD and THC are cannabinoids that both come from the cannabis plant.The PICO strategy was used to formulate the question of this review. While the opioid crisis increases, CBD's role in pain management unveils as animal studies show promising evidence . Different types of chronic pain are identified based on their nature, location, and characteristics. In conclusion, CBD is an excellent alternative to an opioid in chronic pain because CBD is non-intoxicating in its pure form. Cannabinoids, including the two main phytocannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), are being increasingly utilised as pharmacological interventions for sleep disorders. Longitudinal research should be done in order to understand the clinical impact of CBD on sleep. With the crisis of opioid use and dependence, medical providers and the government need to work hand in hand to urgently find alternatives to the treatment of chronic pain, whatever the reason may be . The secondary outcome reported that 89 (94%) improved quality of life as measured by pain and sleep-related open-ended questions. While Rabgay concluded that the evidence is insufficient to determine CBD’s efficacy in pain, Boyaji found it challenging to recommend CBD’s use in chronic pain. CBD Oil for Sleep: Is it Effective? Is it Safe? Is it Legal? One association often reported by users is sedation and subjective improvements in sleep. Cannabis and its pharmacologically active constituents, phytocannabinoids, have long been reported to have multiple medicinal benefits. Findings suggest 20 mg of CBN taken nightly may be helpful for improving overall sleep disturbance, including the number of times one wakes up throughout the night, without impacting daytime fatigue. No differences were observed for latency to sleep onset or WASO. The addition of CBD did not positively augment CBN treatment effects. Side effects are more likely to occur when you first start taking CBD28 and then go away as your body adjusts to the new supplement. Aside from that, while CBD is generally well-tolerated, it can trigger side effects in some people. For starters, those on blood-thinning medications, like anticoagulants and antiplatelet drugs, should always talk to their healthcare provider before taking CBD. It combines three essential oils — bergamot, lavender, and chamomile — with CBD extract. The oil is available in three flavor options, including chocolate mint, strawberry lemonade, and classic or natural. We also like that most of the ingredients are organic and there are no synthetic fragrances. We like this lotion specifically because it has mostly organic ingredients plus other beneficial compounds like rose water and willow bark, and it doesn’t contain any synthetic fragrances. Some studies also suggest that just smelling lavender before bedtime can help you wake up feeling more refreshed12. Dosage levels ranging from 150 to 400 milligrams per day8 have been shown to be effective, at least in terms of treating anxiety. Some short-term effects include impairment of memory and motor coordination, paranoia, and psychosis (with high doses). In general, several short- and long-term adverse effects can occur with cannabinoid usage. Commonly noted side effects included increased somnolence, dizziness, euphoria, disorientation, and paranoia. A meta-analysis, including 79 randomized control trials, summarized the benefits and adverse effects of their medical use. This resulted in blockade of excessive sleepiness during the lights-off period. Five databases (PubMed, PubMed Central, Medline, Cochrane Library, and ScienceDirect) were searched using cannabidiol, CBD, hemp, and chronic pain. We conducted a systematic review to determine the efficacy and safety of cannabidiol (CBD) for chronic pain. Many of the reviewed studies suggested that cannabinoids could improve sleep quality, decrease sleep disturbances, and decrease sleep onset latency. The present study sought to determine the effects of cannabinol (CBN) alone and in combination with cannabidiol (CBD) on sleep quality. Another retrospective study15 looking at two cannabis clinics found that patients with and without sleep as their primary concern noticed a significant decrease in the amount of time it took to fall asleep. FDA regulation of CBD needs more clinical trials to determine its effectiveness and safety and should meet proper standards for authorization . Chronic pain is a continuous or recurring pain for three months or longer experienced by a patient due to various causes. Food and Drug Administration (FDA) is Epidiolex, an oral solution given to patients less than two years old to treat two rare and severe forms of seizure, Lennox-Gastaut syndrome and Dravet syndrome . More clinical trials should be done to prove CBD's significance clinically and statistically. CBD and tetrahydrocannabinol (THC), both from Cannabis plants with almost identical chemical structures, attach to the CB receptor, eliciting different effects like the psychoactivity seen on THC but less or none in CBD. If you want to take CBD orally but don’t want oil, you can opt for gummies instead. However, some don’t like the taste of oils, especially if they’re unflavored. An oil/tincture is a common choice since it works quickly and is easy to drop in your mouth. This offers the specific benefits of cannabidiol but doesn’t have the same synergistic effect as full-spectrum options. All the other cannabinoids have been removed, and you’re left with about 99 percent CBD31 depending on the specific product. Individuals receiving 20 mg CBN demonstrated reduced nighttime awakenings and overall sleep disturbance relative to placebo, with no impact on daytime fatigue.While all high-quality CBD oil may help with sleep in some way, you might also want to consider your (and the product’s) intended use.These questions include further elucidation of the dichotomy between the effects of THC and CBD, as well as identifying any long-term adverse effects of medicinal cannabinoid use.More clinical trials should be done to prove CBD's significance clinically and statistically.However, a few studies are showing the benefits of CBD not only for chronic pain but also for sleep improvement and quality of life. That being said, melatonin is also a notably effective sleep aid. It also contains 5 milligrams of melatonin, which may be a plus or downside depending on what you’re looking for. The company complies with cGMP best practices and makes their products in an FDA-registered facility. This cream was formulated by physicians from the Mayo Clinic, and it’s made from CBD that was grown on certified organic farms in Colorado. Currently, some placebo-controlled trials are underway for evaluation of the effects on sleep apnea and insomnia . Human studies are needed to further evaluate their potential therapeutic role. With studies of limited sample size and lack of long-term outcomes, the role of cannabinoids in RBD remains largely undetermined. A case series evaluating CBD for treatment of insomnia in patients with post-traumatic stress disorder (PTSD) showed decreased sleep disturbances per the Pittsburgh Sleep Quality Index (PSQI). Though these preliminary human data are promising, larger follow-up studies including randomized control trials are needed to assess long-term efficacy and potential adverse effects. Scientists and researchers are looking for alternative means to address chronic pain using more substantial evidence from clinical trials and observational studies. Hence, more research and studies are being done to give patients with chronic pain an efficacious and safe alternative to the existing kinds of pain medication available on the market. Using MeSH and keywords like cannabidiol, CBD, hemp, and chronic pain, 2298 publications were obtained. This study will fill the existing gap and update knowledge on CBD's role in chronic pain. One study14 involving patients with insomnia found that a moderate dose of 160 mg/day increased the total amount of sleep time and decreased the number of awakenings during the night. We have also learned that the body can manufacture endogenous cannabinoids that act as chemical messengers, and using cannabis-based products have similar effects. Medical cannabis is available in some states with a prescription and is commonly used for treating chronic pain, back pain, and several other conditions. Lindsay Boyers is a functional nutritionist with extensive experience in sleep, supplements, and other areas of health and wellness. Since research is still fairly limited, there isn’t a conclusive recommendation for the “best” CBD dosage for sleep. Broad-spectrum oils and isolates have all of the THC removed. Dozing off during the day and extreme fatigue are also signals to call your healthcare provider. Difficulty falling asleep more often than not and/or constantly waking up in the middle of the night are both signs that something may be wrong. A total of 12 studies were found eligible for this review. Figure 1 is a PRISMA 2020 flow diagram showing how related studies included in the review were identified . Furthermore, other publications in the reference list and related studies were also examined to see if they were relevant and could be included in this review. Patients with chronic conditions such as fibromyalgia frequently report insomnia. There is also increased evidence of improvement in insomnia symptoms secondary to chronic conditions. Another study found that CBD had a positive effect on anxiety-related REM sleep suppression but no effect in the NREM phase. While some studies have demonstrated decreased insomnia severity with their use, most have shown mixed results. The mixed (inhalation + non-inhalation) route is preferred (45% of respondents), and this is attributed to the tailored pain relief experienced .Due to their anxiolytic effect, cannabinoids have been historically used as sleeping aids .New Castle Ottawa Tool is used to evaluate the eligibility of two observational studies in Table 5.Some gummies are loaded with artificial ingredients, but these CBD Sleep Gummies from Cornbread Hemp have a fully organic ingredient list with minimal amounts (2 grams) of sugar.Practicing good sleep hygiene is an often overlooked lifestyle modification that can be extremely helpful for many people.You can reduce the chances of side effects by starting slowly and giving your body time to get used to the CBD. Our review summarizes the mechanism, role, and current body of literature on cannabinoids in various sleep disorders. Another study on treatment-resistant PTSD patients showed reduction in intensity of nightmares while improving sleep quality and time as well as decreasing flashbacks . Before it can be reliably considered a choice for insomnia treatment, larger controlled studies are needed to better evaluate optimal doses as well as effects on various sleep stages. Given the known effects of endocannabinoids on the serotonin receptors, it has been postulated that these compounds may also have a role in respiratory stabilization and management of sleep disordered breathing. Obstructive Sleep Apnea and Central Sleep Apnea Lindsay Boyers is a functional nutritionist with extensive experience in sleep, supplements, and other areas of health and wellness.Some short-term effects include impairment of memory and motor coordination, paranoia, and psychosis (with high doses).Studies in rats injected with increasing dosages of CBD showed an increase in total percentage of sleep, with a decrease in REM latency at lower doses and an increase in REM latency at higher doses 40, 41.Conflicts of interest RRG and NSM have received discounted investigational products for an unrelated clinical trial from Neurim Pharmaceuticals Inc.For starters, those on blood-thinning medications, like anticoagulants and antiplatelet drugs, should always talk to their healthcare provider before taking CBD.On the other hand, Capano et al. did a prospective cohort study (with 97 participants) about the effect of CBD hemp extract on patients with chronic pain taking opioid medication .Side effects are also more likely with high doses of CBD, although research shows that 1,500 milligrams of CBD29 (a very high dose) is well tolerated by most people.Some report improvement in sleep with CBD use, while others report increases in wakefulness 28, 93.In a review done by VanDolah et al., more studies focused on the benefits of prescribed THC drugs; on the other hand, four studies were linked to CBD’s potential therapeutic actions, safety, and adverse effects .With studies of limited sample size and lack of long-term outcomes, the role of cannabinoids in RBD remains largely undetermined. A randomized crossover study comparing 4 nights of normal sleep (8.5 h) to sleep restriction (4.5 h) in healthy individuals showed amplified blood levels of endocannabinoids from mid-sleep to early afternoon when compared to normal sleep. The above studies identified a potential role of these compounds in various circadian rhythm disorders; further investigation is underway on utilizing them for therapeutic purposes. A study by Farabi et al. examined effects of dronabinol on quantitative sleep measures and found an increase in ultradian rhythms and changes in theta and delta frequencies, thus showing improved apneas and increased wakefulness . Thus, studies on the isolated effects of CBD on sleep architecture are limited and mostly have mixed results. Most of these studies evaluated the effect of THC and cannabis; thus, data on effects of CBD are lacking . CBD VITAL Schlaftropfen mit Hanf und Melatonin If you’d rather avoid THC completely, broad-spectrum CBD contains all of the cannabinoids except for THC. Studies suggest that full-spectrum CBD is the most effective30 of all types since all these cannabinoids work together. You can reduce the chances of side effects by starting slowly and giving your body time to get used to the CBD. In a review done by VanDolah et al., more studies focused on the benefits of prescribed THC drugs; on the other hand, four studies were linked to CBD’s potential therapeutic actions, safety, and adverse effects . This paper aims to answer the efficacy and safety of CBD in chronic pain using a systematic review of articles from five databases. The current literature focuses mostly on the use of tetrahydrocannabinol (THC) and/or cannabidiol (CBD) in the treatment of chronic health conditions such as multiple sclerosis, posttraumatic stress disorder (PTSD), and chronic pain. Some studies show that using bergamot oil before bedtime can relax the mind and body, but it may also make it easier to wake up in a good mood21. All three essential oils can help improve sleep, but bergamot has additional benefits. Specifically, this roller combines 100 milligrams of full-spectrum CBD with lavender oil, chamomile oil, and bergamot oil. This means that each one-milliliter dose will contain 20 milligrams of both CBD and CBN per serving. It combines 600 milligrams of CBD with 600 milligrams of CBN, or cannabinol, per bottle. I’ve personally been taking CBD oil for the past four years and, as a functional nutritionist, I’ve heavily researched it too. This can make it difficult to separate high-quality CBD from sub-par options. In the future, clinical trials should focus more on using pure CBD extract to treat chronic pain to attain evidence to properly recommend CBD in the health insurance sector so that patients may benefit to the full extent. Some observational and clinical studies lead to CBD’s effectiveness and safety in chronic pain; however, the evidence is not strong enough to obtain a proper recommendation. These two observational studies mentioned above hold decent evidence of the positive effect of CBD on chronic pain, like reduced opioid intake and improved sleep. Considered as a psycho-inactive component, recently, the Court of Justice of the European Union published a ruling in which it establishes that cannabidiol extracted from the cannabis plant should not be considered a drug under the United Nations Single Convention on Narcotic Drugs of 1961. Cannabidiol (CBD) is one of 113 cannabinoids identified in cannabis plants. Working with a healthcare provider with expertise in using medical cannabis would be helpful to guide your therapy. Cognitive behavioral therapy for insomnia (CBT-i) is a form of treatment that involves working with a therapist to focus on changing behaviors that may be negatively impacting sleep. Many people use essential oils like lavender, chamomile, blue tansy, and cedarwood to help them fall asleep. Another nod to the company, Lazarus Naturals grows their hemp on their own farms, so they have full control over manufacturing. This tincture has the highest concentration of CBD (30 milligrams) with equal amounts of CBN (10 milligrams) and CBG (10 milligrams) in each serving. Full-spectrum CBD is the gold standard for effectiveness, and this tincture from Lazarus Naturals may be extra helpful for sleep thanks to the higher concentration of CBN and CBG (cannabigerol). The effects of these compounds on various stages of sleep with different modes of administration including inhalational or oral use have been evaluated in some small studies revealing variable effects on sleep stages. CB1 receptors have been shown to enhance the activation of the serotonergic system yielding a potential regulatory role in the sleep-wake cycle 24, 25. Summary of effect of cannabis and THC on sleep architecture (short term, long term and effects of withdrawal of cannabis) According to Forbes, in October 2020, cannabidiol (CBD) sales in the United States reached $4.2 billion after the federal government legalized hemp-derived CBD in 2018 . Inclusion criteria were applied, and quality assessments were done, resulting in 12 publications eligible for the review. The Cochrane risk of bias tool was used to assess the quality of trials that compared cannabinoids with control interventions. PubMED, Web of Science, and Google Scholar were searched using terms and synonyms related to cannabinoids and sleep. Participants were years of age who self-rated sleep quality as "very poor" or "poor." The primary endpoint was sleep quality, while secondary endpoints included sleep onset latency, number of awakenings, wake after sleep onset (WASO), overall sleep disturbance, and daytime fatigue. Another possible contributor is a terpene called myrcene, which is found naturally occurring in certain types of the cannabis plant10. Research9 has found that people may experience an endocannabinoid deficiency that results in many different symptoms, including difficulty with sleep. This complex network of cannabinoid receptors is found throughout the body and in the central nervous system, where sleep is primarily regulated. This full-spectrum CBD oil is grown and sourced in the USA, featuring third-party certifications and a risk-free 30-day trial.THC alone has been shown to decrease sleep latency but with long-term use it can decrease total sleep, likely due to tolerance of effect .Therefore, there is fear on the patients’ part about CBD’s availability after research and the financial cost they would have.The present study sought to determine the effects of cannabinol (CBN) alone and in combination with cannabidiol (CBD) on sleep quality.There’s also evidence that CBD may help reduce feelings of anxiety3, which can indirectly improve sleep if anxiety is what’s keeping you up at night.Some of the potential therapeutic actions of CBD include relief of chronic pain, sleep disorders, spasticity and Tourette syndrome, nausea and vomiting in chemotherapy, and weight gain in HIV patients, to name a few.We have also learned that the body can manufacture endogenous cannabinoids that act as chemical messengers, and using cannabis-based products have similar effects.THC attaches to cannabinoid receptor 1 (CB1) while CBD attaches to several receptors like CB receptors, transient receptor potential vanilloid 1, G protein-coupled receptor 55, and serotonin 5-HT1A .An open-labeled study evaluated the role of THC in chronic PTSD, finding improvement in sleep quality and decreased nightmare frequency; however, some minor side effects were reported (e.g., dizziness, headache) . Keep in mind that the effectiveness of any supplement or prescription medication will depend on the reason you are struggling with poor sleep to begin with. If it’s not right for you, there are some other natural alternatives for sleep that you can try. After doing your research and speaking with your healthcare provider, you may decide to pass on CBD. Because research is still limited, there may be other solutions that have been well-studied for the treatment of sleep-related difficulties that work better for you. It is important to speak with a healthcare provider if you are currently taking any prescription or over-the-counter medications. Recently, some randomized controlled trials (RCTs) are underway evaluating the effect of various cannabinoid products on chronic insomnia, which includes use of various combinations of CBD, THC, and cannabinol (CBN) or CBD alone 64–66. It is unclear if this is due to the effect of marijuana on sleep quality or better pain control . Animal studies on Sprague rats by Carley et al. showed stabilization of respiratory patterns during sleep after injection of THC intraperitoneally, with dose-dependent effects on apneas. Inhalation of cannabis has variable effects on airways with acute versus chronic use. Moreover, a recent study further investigating the effect of sleep debt and the role of the endocannabinoid system found that there is enhanced encoding of food odors in the piriform cortex, which shifted food choices to more energy dense foods. This CBD lavender lotion is a topical product with 200 milligrams of broad-spectrum CBD, organic lavender water, and lavender oil. MedTerra’s Isolate CBD Oil combines 99.6 percent U.S.-grown hemp with certified organic MCT oil. The Head & Heal’s CBD oil is designed for sleep, as it combines 600 milligrams of CBD and 600 milligrams of CBN, which is a milder version of THC. Cannabinoids (CBD and THC) have variable effects on different sleep stages (as demonstrated by the hypnogram in Fig. 1). Due to their anxiolytic effect, cannabinoids have been historically used as sleeping aids . Given limited therapeutic drug options and the potential deleterious health effects of available pharmacological agents, investigation of additional therapeutics is warranted. Furthermore, evidence of PAP therapy converting obstructive apneas to central apneas may support the role of dysregulated central motor pathways in the pathology of obstructive sleep apnea. In a review done by Boyaji et al. on seven studies using nabiximols (CBD+THC) spray as a medication for pain, four RCT studies concluded a positive effect on their pain while on nabiximols spray compared to placebo . A low dose for pain relief was used for all studies reviewed and exhibited an average dose of 19.82 mg/day . They found out that cannabis and cannabinoids act on different types of pain depending on the dosage and route of administration. Furthermore, Rabgay et al. conducted a systematic review of 25 studies with 2270 patients regarding the different dosages and routes of administration for CBD . In a systematic review of 229 studies done by Pagano et al., the effects of CBD on healthy cell characteristics such as cell viability, cell proliferation, wound repopulation, apoptosis, and cell cycle were tackled . They come in two strengths — 750 milligrams and 1,500 milligrams — and you’ll get 25 or 50 milligrams of CBD per serving, depending on which one you choose. Some gummies are loaded with artificial ingredients, but these CBD Sleep Gummies from Cornbread Hemp have a fully organic ingredient list with minimal amounts (2 grams) of sugar. Yet, all products are still third-party tested and all COAs are available on the website. Is CBD Oil Safe? The outcome of each study mentioned above can set a new playing field for pharmaceutical companies for drug development to explore and investigate using clinical trials in a large sample population.The content of CBD and timing of use showed that CBD with sedation effects (Indicas) is usually taken at night.In addition to the high-quality formulation, there’s a lot of good to say about the company itself, too.Due to increased publicity on social media of the supposed benefits of this product, in addition to the lack of clear regulations, it is becoming a widely used treatment for sleep disorders.With their known anxiolytic role, cannabinoids remain of interest and have been under investigation for PTSD.Cannabidiol is available as a crystalline isolate, meaning it has been purified to contain only CBD, or as a full-spectrum oil containing a variety of compounds including cannabinoids, terpenes, and essential oils.In summary, most of these studies evaluating effects of cannabis and cannabinoids are limited by differences in study designs, sample sizes, and procedures, as well as the ratios of THC to CBD used.Cannabinoids, including the two main phytocannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), are being increasingly utilised as pharmacological interventions for sleep disorders. Conflicts of interest RRG and NSM have received discounted investigational products for an unrelated clinical trial from Neurim Pharmaceuticals Inc. Promising preliminary evidence provides the rationale for future randomised controlled trials of cannabinoid therapies in individuals with sleep apnea, insomnia, post-traumatic stress disorder-related nightmares, restless legs syndrome, rapid eye movement sleep behaviour disorder, and narcolepsy. A total of 14 preclinical studies and 12 clinical studies met inclusion criteria. To analyse literature for the effect of CBD in sleep disturbances, emphasizing advantages and disadvantages of its use. Another study with 2224 patients by Maurer et al. revealed that the patients’ post-injury three and four-week use of cannabis after concussions resulted in a lower severity score but not faster recovery from concussion symptoms . With this, more people have gained access to CBD, especially those with chronic pain on pain medications, and have experienced promising outcomes. Studies with pediatric patients, acute pain, and animal studies were excluded. The keywords "Cannabidiol" and "chronic pain" were applied to obtain related literature. An open-labeled study evaluated the role of THC in chronic PTSD, finding improvement in sleep quality and decreased nightmare frequency; however, some minor side effects were reported (e.g., dizziness, headache) . On the other hand, Capano et al. did a prospective cohort study (with 97 participants) about the effect of CBD hemp extract on patients with chronic pain taking opioid medication . Some of the potential therapeutic actions of CBD include relief of chronic pain, sleep disorders, spasticity and Tourette syndrome, nausea and vomiting in chemotherapy, and weight gain in HIV patients, to name a few. However, a few studies are showing the benefits of CBD not only for chronic pain but also for sleep improvement and quality of life. To further examine this association, we conducted a critical review of clinical studies examining the effects of cannabinoids on subjective and objective measures of sleep. It also contains 5 milligrams of melatonin, which helps you sleep better. This cbdMD tincture has a blend of sleep-supporting ingredients such as chamomile, lemon balm, valerian root, and hops. This CBD cream helps with pain and soreness, featuring a combination of organic menthol and organic arnica. The Cornbread Hemp sleep gummies have organic ingredients and only two grams of sugar. The Lazarus Naturals CBD oil comes from the hemp grown on Lazarus Farms. Some of the most popular and widely used herbs known for their sedative effects include valerian root, chamomile, passionflower, St. John’s wort, Ginkgo biloba, lemon balm, and kava. Many herbs have been researched for their safety and effectiveness as natural sleep remedies. Research19 has found that supplementing with melatonin may help to improve sleep, especially for shift workers or those suffering from jet lag. Melatonin is a natural hormone produced in the brain in response to sunlight and darkness and helps to regulate the sleep-wake cycle known as the circadian rhythm. During sleep, there are various autonomic changes including transient apneas, which are more frequent during REM. At clinical doses, these compounds lack any direct depressive effect on central respiratory centers unlike other psychoactive substances such as opiates . There is a suggestion that the endocannabinoid activity may be misaligned with central circadian rhythm especially in obese individuals highlighting its role in weight gain and reported preference of later timing of food intake . CB1 receptor antagonism in rodents after 4 h of light has also been shown to yield increased time spent in wakefulness and decreased time in SWS and REM sleep 47, 48. However, it is important to note that chronic use may lead to habituation. With this in mind, consider taking your CBD oil about an hour or so before your planned bedtime and see how that timeline works for you. They found an increase in total sleep time and a decrease in the amount of nighttime awakenings.12 Cannabidiol (or CBD for short) is one of hundreds of known cannabinoids that are derived from the Cannabis sativa plant. Here at Sleep Advisor, our editorial team utilizes reputable sources and expert feedback to provide well-researched sleep health content. Though widely utilized historically and legally in many parts of the world, robust knowledge about the effects of these substances, especially long term, is lacking. This population also has a higher potential for dependence and has been shown to have higher rates of mental impairment in adulthood . Other effects include dry mouth/throat, dry eyes, polyphagia, hyperemesis, inhalation-related burns, and risk of acute respiratory distress syndrome (ARDS) . Of the studies that performed hypothesis testing, 4 of 7 studies with a CBD predominant arm and 12 of 16 studies with a nearly equal ratio of CBD to THC arm reported significant improvement in insomnia outcomes. All studies reported improvement in the insomnia symptoms of at least a portion of their participants. CBD is often used by patients for the management of insomnia, yet research supporting CBDs effectiveness as a treatment for insomnia is inadequate. Even states and territories of the U.S. differ on cannabis regulations, mainly because of the possible risks outweighing the benefits and the availability of pure CBD products. Although CBD and THC come from the same cannabis plant and have almost identical chemical structures, they attach differently to a CB1 receptor, eliciting different effects. There’s also evidence that CBD may help reduce feelings of anxiety3, which can indirectly improve sleep if anxiety is what’s keeping you up at night. Mainstream CBD use is still fairly new, which means we still have a lot to learn about how it works and its potential health benefits. Here at Sleep Advisor, our Sleep Certified experts use a refined mattress and product testing process to give you unbiased product suggestions… Read our full product review process. Transparency Disclosure — We may receive a referral fee for products purchased through the links on our site…Read More. Additionally, several studies used nonvalidated subjective measures, and most studies failed to include objective measures for symptom assessment. Vigorous activities tend to have a stimulating effect and are best done in the morning or afternoon hours so they don’t interfere with falling asleep at night. Getting moderate exercise on a daily basis may help to improve sleep. This mineral may help to boost certain levels of neurotransmitters in the brain that influence sleep. Essential oils can be used by inhaling directly from the bottle, placing a few drops on a pillow, or using an aromatherapy diffuser. It is suggested that CB1 receptors located in the pons and basal forebrain may be involved in sleep induction . This load compensation can be further pathologically reduced in conditions like obstructive sleep apnea (OSA) . This ventilatory load is normally counteracted by compensatory mechanisms in the awake state but is delayed during sleep . Further, there is reduction in the tone of other upper airway and intercostal muscles which leads to increased upper airway resistance, decreased thoracic movements, and ultimately hypoventilation which becomes especially pronounced during REM sleep . In comparison to THC, CBD is a relatively new drug, and studies are limited to establishing its safety and efficacy. The studies complement each other in strengthening the value of CBD medically when used on different body parts. Its adverse effects include liver toxicity, somnolence, decreased appetite, diarrhea, and low blood pressure . The stimulation of CB1 receptors produces the psychotropic effects experienced with THC consumption but is not evident in CBD use. This difference makes THC a potential partial agonist to the CB1 receptor and CBD a negative allosteric modulator, on the other hand . The current systematic review assessed the available evidence base using PubMed, Scopus, Web of Science, Embase, CINAHL and PsycInfo databases. However, their therapeutic efficacy and safety as treatments for sleep disorders are unclear. THC and CBD are known to interact with the endocannabinoid and other neurochemical systems to influence anxiety, mood, autonomic function, and circadian sleep/wake cycle. The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. In addition, it was difficult to find studies that focused on CBD alone since THC is often mixed with it. Clinical trials on CBD are also scarce because it is relatively new and obtaining a good quality product is still a problem. When evidence of CBD’s pain relief is fully recognized, guidelines need to be applied to the health insurance business to lessen its financial burden on the patient. Regulations and categories of CBD need to be updated to make clinical trials easier. Of the 34 studies, 19 studies used CBD predominant therapy and 21 studies used nearly equal ratios of CBD to Δ9-tetrahydrocannabinol (THC). Risk of bias was assessed with the Agency for Healthcare Research and Quality design-specific recommended criteria. The search included randomized controlled trials, nonrandomized experimental studies, cross-sectional studies, cohort studies, case series, and case reports. In addition, Scuteri et al., a systematic review of four studies, revealed that CB2 agonist HU308 alleviates inflammation in the eyes by reducing uveitis-induced leukocyte adhesion and lipidome profile changes . THC and CBD are famous examples of these phytocannabinoids obtained from marijuana and hemp, respectively. Phytocannabinoids can be extracted from the cannabis plant, and this active chemical, when combined with the receptor, affects the functioning of the body in many ways. Detailed quality appraisals with the corresponding tools used for each study are shown below. A summary of the studies and the quality appraisal tool used for each one is shown in Table 1. Studies suggest that a short use of medium to hight doses of CBD may improve insomnia, however, combined use with THC may result in a decrease in slow wave sleep. The review of the effect of CBD on sleep cycle suggest that medium to high doses increased REM sleep latency, and medium-low doses decreased REM sleep latency. We carried out a literature review in Pubmed choosing those articles focused on effect of CBD in sleep disturbances. The central and peripheral chemo- and mechanoreceptors respond to changes in oxygenation and ventilation, but this response also varies between sleep and wakefulness, becoming more pronounced during REM sleep. Respiratory patterns vary during sleep with a regular respiratory pattern in NREM sleep and a more irregular pattern in REM sleep. Along with changes in neuronal activity, there are dynamic fluctuations in physiology during sleep that involve the cardiovascular, autonomic, respiratory, and endocrine systems. REM sleep is also promoted and maintained by cholinergic neurons located in the dorsolateral pons . These sleep-promoting regions are primarily regulated by inhibitory neurotransmitters like gamma-aminobutyric acid (GABA) or galanin. CBD on the other hand is a noncompetitive antagonist of CB1 receptors, with somewhat counter effects of THC, thus reducing the potency of THC. Its various effects may differ depending on the dose, with low doses having a sedative effect, moderate doses having a stimulant effect, large dose having a hallucinogenic effect, and very large doses having a psychotic effect. The serotonergic transmitter system located in dorsal raphe nucleus of the brainstem is also involved in modulation of the sleep-wake cycle . This process is possibly related to activation of cholinergic neurons located in the basal forebrain and pons via CB1 receptors, assisting in the induction of sleep . Recently, an animal study described the role of CBD in an orexin-deficient rat with narcolepsy which was injected with CBD at the beginning of the dark phase . This differential effect may be due to the heterogeneous methods used in the various studies evaluating the impact of CBD on sleep and wakefulness . In contrast to the well-established role of THC in sleep promotion, CBD’s effect is contradictory . To date, these represent the limited data available on evaluating the role of cannabinoids in RBD. A crossover study with nabilone that evaluated various polysomnography (PSG) parameters demonstrated increased sleep efficiency and total sleep time, as well as decreased arousal index; however, there was increased sleep onset latency . MedTerra keeps a close eye on production, and all CBD oil is third-party tested and certified by the U.S. While this CBD isolate doesn’t offer the entourage effect of full-spectrum CBD, it’s a good choice for those who are looking for pure cannabidiol. This full-spectrum CBD oil is grown and sourced in the USA, featuring third-party certifications and a risk-free 30-day trial. Additionally, Head & Heal is farmer-owned — the company has their own farms where they also grow organic vegetables — so there’s more control over the manufacturing and production. While more research is needed to make definitive claims, there’s preliminary scientific evidence — and plenty of anecdotal evidence (myself included) — that CBN can help promote sleep5. And if pain or neuropathy is keeping you up at night, the CBD in this lotion may help ease that13, which can indirectly help with sleep. CBD topicals aren’t as well-studied for sleep as they are for pain management, but this CBD Lavender Lotion from Calm by Wellness pulls double duty. That said, multiple studies have shown that higher doses may be necessary to experience the potential benefits. Short-term use of CBD may improve insomnia by decreasing the amount of time it takes to fall asleep and increasing NREM, slow-wave sleep. There is no definitive research on the ideal time to take CBD oil for sleep as it depends on the product composition and the dose. Some medical professionals believe that CBD improves rest by reducing anxiety and pain, allowing people to relax and, in turn, fall asleep more easily.