Studies show mixed results for people who used low doses of CBD spray, applied under the tongue, to treat chronic pain. A 2021 study found that CBD helped improve anxiety for people with moderate to severe disorders, but it made people with mild anxiety more anxious. In a 2022 clinical trial, 14 people with anxiety were given high levels of CBD under the tongue, for four weeks, three times per day. Using CBD products can also cause side effects. Relevant information was summarized in Table 7 to show an overview of each study collected from the databases. New Castle Ottawa Tool is used to evaluate the eligibility of two observational studies in Table 5. Detailed quality appraisals with the corresponding tools used for each study are shown below. IRB (Institutional Review Board) Approval and Informed Consent Among participants, 62.0% reported trying a CBD product including products containing delta-9-tetrahydrocannabinol (THC). The aim of this survey was to learn about participants’ attitudes and views towards cannabis-based medicine (CBM) with a focus on perception of “CBD” and its potential role for pain management. Based on the available literature, it is difficult to make a recommendation for the use of CBD in chronic pain management. At present, there is insufficient evidence to recommend CBD for the treatment of pain. Although CBD has been found to reduce pain in several animal models of inflammatory and neuropathic pain, studies to date lack sufficient rigor to provide more than modest evidence for the analgesic activity of CBD. As you can see, there are many health benefits of using CBD oil, but could CBD actually help you lose extra weight and speed up your metabolism? Hypertension is a major risk factor for a variety of health conditions, including metabolic syndrome, atrial fibrillation (AFib), heart attack, or stroke. When it comes to CBD oil benefits, cardiovascular health is another quite well-studied area. Although this is still a relatively new research area, several studies have already pointed to CBD as an effective treatment for neurological disorders. Despite these promising results, more human studies on the effects of CBD on acne are needed. However, there is a challenge for patients to report the actual outcome observed because health insurance covers opioid medication but not CBD. Boehnke et al. reiterated in this study that subgroups in the sample population are essential in analyzing the results of CBD use . The content of CBD and timing of use showed that CBD with sedation effects (Indicas) is usually taken at night. It was noted that the younger population uses inhalation while older people prefer the non-inhalational route. WebMD does not provide medical advice, diagnosis or treatment. It’s also a good idea to buy CBD from licensed sellers to avoid contaminated or mislabeled products. Some research suggests that cannabis enhances people’s sexual experience by helping them relax. We've compiled seven benefits of using CBD for pain management below so you can check here and decide if cannabidiol extract is right for you. Now that CBD products are legal in states across the nation, you may have noticed how quickly acceptance of this once-controversial substance has spread. Chronic pain is a debilitating condition that affects millions of people worldwide. These products are not intended to diagnose, treat, cure or prevent any disease. Our team, a diverse group of passionate individuals, includes certified CBD consultants, agricultural hemp pioneers, holistic health experts and wellness authors – about us. The review from Harvard Health gives a straightforward overview of where CBD shines, listing real conditions and situations where CBD had a notable impact on pain and inflammation. If you’re feeling stuck or unsure about product types or how to use CBD for pain, even a short chat with a provider or a qualified wellness expert can make your path smoother. “In the brain, whole product CBD has improved a range of anxiety related issues, including generalized anxiety, social anxiety, and post traumatic stress.This systematic review aims to determine the status of the efficacy and safety of CBD on chronic pain.There is a high price tag on good quality CBD available, and affordable CBD products are not 100% reliable due to some manufacturers' mislabeling issues about their exact content.There has been a growing level of interest in research on the topical usage of a cannabis-based extract as a safer and more effective alternative to the usage of topical corticosteroids in treating some dermatoses.Prices range widely but CBD products aren't inexpensive, and depending on dose, frequency, and formulation, the cost can be considerable, and health insurance does not usually cover it.While the familiarity with dosing was mixed and participants used a wide variety of products including products containing THC, they report that these products have helped them with many different pain-involving and neurological conditions.Medical cannabis expert and double-board certified doctor, Dave Gordon, M.D., agrees that CBD’s ability to influence the ECS is what makes it such a versatile tool.All other conditions and products reported can be viewed in detail in Table 1 and verbatim responses are listed in Supplemental Table 3. A majority described some positive effects of CBD products on their conditions and reduction of pain medication. “We need to understand more about this compound, what mechanisms it interacts with in the brain, its impact on the body, and whether it is a potentially safer solution for treating the chronic pain epidemic,” said Kuan Hong Wang, PhD, professor of Neuroscience and member of the Del Monte Institute for Neuroscience at the University of Rochester, whose lab in collaboration with researchers at Harvard Medical School and Boston Children’s Hospital, recently discovered that in mice, they could effectively deliver CBD to the brain for neuropathic pain relief with no adverse side effects. Over the past decade, the use of cannabis products for pain management has increased, in part because in 2018 Congress signed a law removing hemp from the federal Controlled Substances Act, thereby legalizing hemp-derived CBD. The data sources used in the review process were PubMed and Web of Science; the aim of the search was to find and analyze all the articles that were preclinical and clinical studies on CBD isolated or as a major component of cannabis without the presence of THC for the treatment of pain. Meanwhile, the administration of 150 mg of CBD oil every 24h in two doses did not deliver pain relief due to the performance of physical exercise in people unaware to training in Chicago (United States) . In vitro studies with human skin have shown that the permeability of CBD is ten times higher than that of delta-9-THC and delta-8-THC, which explains the wide use of CBD-based products topically for pain treatment . With the science growing, CBD’s role in pain relief continues to be mapped out—one study and personal story at a time. CBD oil is a concentrated extract from the whole cannabis plant. To date, only one clinical study has been completed with regards to Cannabidiol. The majority of evidence supporting the health benefits comes from animal studies or smaller human trials. CBD stands for cannabidiol, the second major chemical in the cannabis Sativa plant. Antidepressants, pain medications, and blood thinners are some medicines that may interact negatively with CBD. CBD can interact with different medications, causing side effects. Signals called endocannabinoids — similar to cannabis plant molecules — activate our CB1 and CB2 receptors. The study’s authors concluded that these results highlight the necessity of more research into cannabis as a potential tool for harm reduction and as an alternative to prescription opioids for chronic pain. Still, he cautions, there’s a lot left to be studied, including whether there are significant adverse long-term effects of CBD when used for pain relief. Speak to a medical provider before you replace your current treatments with CBD products. CBD, a non-psychoactive compound found in the hemp plant, has emerged as a promising alternative to traditional pain relief methods. CBD has a wide pharmacological activity from anticonvulsant, anti-inflammatory, and antioxidant to antipsychotic effects. It acts by receptor-dependent mechanisms CB1 (greater affinity than CB2) and CB2, which modulate pain, spasticity, sedation, appetite, and mood, in addition to being a bronchodilator, neuroprotector, antioxidant, and anti-inflammatory. Although cannabis is considered a monospecies (Cannabis sativa L.), there are different subspecies and varieties. In addition, the therapeutic properties of this species have been described in Hindu, Assyrian, Greek, and Roman texts, with clear indications for treating pain, inflammation, or lack of appetite. It also highlights the antinociceptive and anti-inflammatory effects of D8-THC, cannabidiol, derivative HU308, and the new racemic CB1 allosteric ligand . In a review done by VanDolah et al., more studies focused on the benefits of prescribed THC drugs; on the other hand, four studies were linked to CBD’s potential therapeutic actions, safety, and adverse effects . Studies with pediatric patients, acute pain, and animal studies were excluded. Topical analgesic properties The two most well-researched phytocannabinoids are the delta-9 tetrahydrocannabinol (THC) and cannabidiol (CBD). There has been a growing level of interest in research on the topical usage of a cannabis-based extract as a safer and more effective alternative to the usage of topical corticosteroids in treating some dermatoses. By providing us with your email address, you agree to CBD Central® privacy policy and terms & conditions. In many cases, as patients become acclimated to specific doses, they are increased, leading to a higher potential for negative effects. Each year, over 630,000 people in the United States die due to heart disease. Ranging from long-term conditions (like valve problems, arrhythmias and more) to life-changing events (like heart attacks or cardiovascular-related strokes), the potential for cardiovascular problems throughout a given individual’s lifespan is great. While there is more research to be done, the fact that CBD could provide relief to those diagnosed with MS is promising. Unlike many other neurological conditions prevalent among older population groups, MS primarily first affects individuals between the ages of 20 and 50. In the future, clinical trials should focus more on using pure CBD extract to treat chronic pain to attain evidence to properly recommend CBD in the health insurance sector so that patients may benefit to the full extent. Some observational and clinical studies lead to CBD’s effectiveness and safety in chronic pain; however, the evidence is not strong enough to obtain a proper recommendation. When evidence of CBD’s pain relief is fully recognized, guidelines need to be applied to the health insurance business to lessen its financial burden on the patient. More published reviews and studies show promising results for the effect of CBD on pain relief, yet there is difficulty in making any recommendations. This product is not intended to diagnose, treat, cure or prevent any disease. It is always optimal to consult with a health care provider when considering what supplements are right for you. Whether you’re seeking a CBD gummy, oil tincture, capsule, or balm, we’ve got you covered. This currently ambiguous situation and somewhat unclear messaging around cannabis-based medications to the public poses the important questions around the current knowledge and believes about these products. To further complicate the picture, cannabis-based medications including CBD products are poorly regulated in terms of their production and testing, vary in purity and consistency, and are often mislabeled.3 As a result, the consumer of cannabis-based medications including CBD often cannot be sure about the actual quality and content of the products they consume. The majority responded that these products have helped their pain (59.0%) and allowed them to reduce their pain medications (67.6%), including opioids (53.7%). CBD oil is a concentrated extract from the whole cannabis plant.All treatment decisions should be determined in partnership with a health care practitioner.CBD oils are products made from CBD extract (a concentrated form of CBD) and an oil, such as coconut oil.High doses can make side effects more likely or strain your wallet without adding much benefit.Topical CBD is popular for those who want quick, localized pain relief without affecting the rest of the body.Now that CBD products are legal in states across the nation, you may have noticed how quickly acceptance of this once-controversial substance has spread.This systematic review can benefit other researchers and even ordinary people eager to know the latest updates on CBD research on chronic pain.For instance, a study published in the Journal of Pain found that CBD significantly reduced pain scores in participants with chronic pain conditions.To better understand the safety profile and possible side effects, Medical News Today provides a breakdown of what studies say about CBD’s safety and risks. In addition to a standalone disorder, anxiety often accompanies other medical conditions making diagnosis a challenge at best. It was life-changing, leading to a series of legislative battles to change the status of medical marijuana and CBD products across the country. Ultimately, adopting a healthier lifestyle can create a synergistic effect with CBD oil, leading to improved pain management outcomes. It’s also wise to avoid products with artificial additives or excessive fillers, as these can dilute the efficacy of the CBD oil. Some studies indicate that dosages ranging from 20 to 50 mg of CBD per day can significantly reduce chronic pain symptoms. This suggests CBD’s benefits aren’t limited to pain signals alone.Buying CBD products from a licensed dispensary can help ensure that a product is safe, as these establishments are regulated in states where cannabis is legal.Because CBD works with specific neurotransmitters to reduce anxiety and increase the ability to focus, initial studies have shown promise in its ability to increase the quality of life by decreasing the symptoms of ADHD for many sufferers.This paper aims to answer the efficacy and safety of CBD in chronic pain using a systematic review of articles from five databases.Stay on top of latest health news from Harvard Medical School.Multiple studies and systematic reviews indicate that CBD can be beneficial in reducing various types of pain, including chronic, neuropathic, and inflammatory pain.These effects are attributed to CBD’s ability to influence serotonin receptors in the brain, which regulate mood and social behavior. Table 5. New Castle Ottawa quality assessment tool for observational studies . Keep track of your pain levels and any changes you experience in conjunction with CBD use, as this information can be helpful in adjusting your regimen over time. Consider setting a consistent schedule for taking your CBD oil, whether it’s in the morning, afternoon, or evening, to establish a routine. CBD may inhibit certain enzymes responsible for drug metabolism, which could lead to increased effects or side effects of concurrent medications. It’s essential to start with a low dosage to gauge your body’s response and minimize the risk of adverse effects. CBD Roll-On Safety and Side Effects: Addressing Common Concerns There’s only one FDA-approved cannabidiol medication, Epidiolex, which is for treating seizures. Cannabidiol, also called CBD, is a chemical in the cannabis plant. CBD is a nonpsychoactive chemical found in the cannabis plant. CBD Hemp Oil for Diabetes (Type Smoking cessation may be one of the many benefits of CBD oil. Specifically, CBD helps suppress pain by targeting a3 glycine receptors, which are found in the spinal cord and brain, controlling the way we react to pain. Cannabis, on the other hand, has been known to reduce pain – and has been used to do so for thousands of years. When inflammation is present, pain can become much worse thanks to biochemical reactions that this inflammation causes. The researchers are optimistic that these compounds could provide a safer alternative for pain management and reduce reliance on opioids. The findings indicate that these three cannabinoids — and CBG in particular — can prevent sensory neurons in the body from sending pain signals to the brain. In the new study, the researchers measured the electrical current in rodent sensory neurons and how the current changed when CBD, CBG, and CBN were introduced. Out of the 11 clinical trials, 7 of them obtained results indicating that CBD treatment has pain-reducing properties 22,24,28,29,30,32,34 in osteoarthritis-related pain, chronic or neuropathic pain, bruxism, arthritis, and atopic dermatitis. The main objective here in this work is to analyze preclinical and clinical evidence on CBD in monotherapy for pain treatment through a review following the PRISMA guidelines . These effects appear to be primarily mediated by the activation of TRPV-1, 5HT-1A, and CB1, with emerging therapeutic relevance in the management of osteoarthritis and chronic pain. On one hand, clinical trials were analyzed using CBD products without THC used in monotherapy, assigning a Jadad score to evaluate the quality/bias of the trials; on the other hand, the main preclinical trials were analyzed, grouping the results into in vivo and in vitro trials. Taken together, the consumer of CBD products faces a landscape in which there is budding scientific evidence of beneficial effects for several conditions against a background of unproven claims and questionable products on the market.List of human clinical trials of CBD in pain management with Jadad score assignment.Unlike other chronic conditions, fibromyalgia is not known to cause muscle or joint damage, but the symptoms it causes are no less devastating.Participants reported improved pain management and overall quality of life, indicating that CBD’s interaction with the endocannabinoid system may play a role in alleviating such issues.In many places, CBD derived from hemp is legal, provided it contains less than 0.3% THC.Inside this guide, you’ll find a list of conditions that CBD can help improve.However, very limited information is available to patients and providers to form an educated opinion regarding its indicated use to treat the many conditions this substance has been implied to be helpful for.Several human studies have linked CBD to positive effects in treating pain related to arthritis or multiple sclerosis. Those who understand the way anxiety can be debilitating – affecting daily functioning and activities and making simple tasks seem impossible – also probably understand the fact that finding a treatment that helps can be a significant challenge. After obtaining cannabis plants at a high cost, and extracting the oil by hand, they saw a major reduction in the number of seizures their daughter experienced. By interacting with these receptors, the sensation of pain is reduced, similarly to how traditional pain management medications act, without the traditional side effects and negatives. While some sufferers of chronic pain resort to traditional marijuana use, it may not be necessary. Overall, our study describes the attitudes and experiences of the participants with CBM and CBD-containing products (medical cannabis) in a pain management clinic environment with a large Medicare and Medicaid patient population. Many of the studies included in the research of CBD also look at the effects of cannabis, which contains both CBD and THC, on pain relief. Much like chronic pain and other chronic disorders, acne – and many other skin conditions – are worsened by inflammation, which often leads to the overproduction of the chemicals and other hormones that cause visible effects. Once again, as with many other disorders, CBD may be a natural option to combat the side effects of traditional anxiety and mental health conditions while providing noticeable relief. The majority of evidence supporting the health benefits comes from animal studies or smaller human trials.This scale allows us to observe that the majority of studies with a high Jadad score (≥4 points) conclude beneficial effects for CBD as an analgesic substance in certain pathological conditions related to pain.Perhaps unsurprisingly, CBD has shown promise in the treatment of autism-related symptoms.A small number of people who took higher doses of CBD had elevated liver enzymes, but no symptoms or jaundice.Though it's often well-tolerated, CBD can cause side effects, such as dry mouth, diarrhea, reduced appetite, drowsiness and fatigue.CBD has been investigated as a treatment for childhood epilepsy,8,9 reviewed as a potential treatment for chronic pain,10–13 and some studies suggest usefulness to treat anxiety disorders.14–16 There is ongoing research about whether the legalization of cannabis products affects opioid use and abuse.Some studies have found a negative relationship between cannabis use and sperm count, as well as other measures of male fertility, including sperm viability and motility. Therefore, it is crucial to assess one’s unique health conditions and pain profiles before integrating CBD into one’s regimen. As the popularity of CBD as a natural alternative for pain relief continues to grow, many individuals have questions about its use, safety, and effectiveness. It is crucial for individuals to understand the specific laws of their own state to ensure compliance and safety when considering CBD for pain relief. States like California and Colorado have established comprehensive frameworks that allow CBD products to be sold in various places, ranging from health stores to mainstream retailers. We then asked the participants about their knowledge of CBD quantity in the product that they have used. We were interested to know whether participants distinguish between medical marijuana and CBD with 63.5% answering “Yes, there is a difference”. Additionally, participants reported that the CBD product helped to reduce the amount of opioid medication specifically “Agree” (26.5%), “Strongly Agree” (27.2%). By further studying CBD’s effects in these specific areas, we may better understand how CBD impacts a variety of conditions and disorders. Plus, Dr. Terpeluk explains the market has been oversaturated with CBD products — from bath bombs to gummies, lotions, creams, tinctures and oil — none of which are Food and Drug Administration (FDA) approved and may not be 100% pure CBD. These days, many of us could certainly go for a miracle cure-all, especially those of us who struggle with chronic pain, overwhelming anxiety, cancer-related symptoms and/or hard-to-treat neurological disorders. It uses natural compounds (endocannabinoids), enzymes, and receptors (like CB1 and CB2) to keep things like mood, sleep, and pain responses in check. Let’s break down what’s happening inside your body when you use CBD and see what recent science says about its effects. Interest in natural pain solutions is growing fast, and CBD is leading the charge. Pills and capsules are typically filled with a liquid version of CBD combined with a carrier oil, such as coconut oil. You can also try tinctures or oils, vape CBD, gobble down edibles (like gummies from Westword.com), or massage CBD-infused lotion into your skin. Many people take CBD orally, but that's not your only option. In many situations, yes, especially if you're looking for a natural pain management solution. CBD is generally considered safe for health. There are benefits for some conditions, and no benefit for others. With so much misinformation and junk-science on the internet, it is important to get solid facts from doctors and scientists you can trust before deciding if medical marijuana could help you. Medical cannabis is available in more delivery methods than ever before, such as gummy bears, dried flowers, pills, lotions, drops and a variety of edibles, but what exactly does it do? For instance, a person experiencing chronic pain may need to start on the higher end of the dosing spectrum compared to someone with mild discomfort. Concurrently, the severity of the pain experienced can influence how much CBD is needed to achieve effective relief. Finally, inflammatory conditions such as rheumatoid arthritis and inflammatory bowel disease have also shown responsiveness to CBD treatment. Neuropathic pain presents another category, characterized by damage to the nerves that may result from conditions like diabetes or multiple sclerosis. A myriad of treatment options exist, from essential oils to prescription medications, laser treatments and more. Maybe because potential treatments seem so harsh, and the negative effects are so easy to see when someone is fighting the disease. That’s just the tip of the iceberg… the positive effects of CBD for anxiety are incredible! Only around 36.9 percent of anxiety sufferers receive treatment for their condition. CBD has been investigated as a treatment for childhood epilepsy,8,9 reviewed as a potential treatment for chronic pain,10–13 and some studies suggest usefulness to treat anxiety disorders.14–16 There is ongoing research about whether the legalization of cannabis products affects opioid use and abuse. It is now our responsibility as medical and scientific communities, working with the FDA, to produce well-designed studies that can either support or disprove the anecdotes about cannabis and hemp by providing a stronger evidence-base for effectiveness in treating pain and other conditions, and continue to press for quality control of any product being consumed by patients. They can help you determine the best approach based on your health history and current medications, ensuring a safe and effective use of hemp CBD oil for pain relief. And a 2019 study found that 80% of chronic pain sufferers who use medical marijuana say they've substituted cannabis for traditional pain medications (both opioids and benzodiazepines) after experiencing fewer side effects and better symptom management. Other clinical trials showed that CBD improved motor function, sleep, and emotional regulation in people with Parkinson’s disease. In a small 2017 study, adults with ADHD who used a cannabis spray saw no difference in cognitive performance but had improvements in hyperactivity and impulsivity. About 85% of patients with epilepsy had better sleep after three months of CBD treatments, according to one study. They reported less anxiety and better mood, sleep, and quality of life, and showed no serious negative side effects. So far, we know that CBD is a proven treatment when it comes to certain types of epilepsy, and early research is showing promise in the treatment of various anxiety disorders. Cannabidiol, abbreviated as CBD, has gained massive popularity since 2018, when it became legal to produce and sell products with CBD in the US. All treatment decisions should be determined in partnership with a health care practitioner. This content is not a substitute for medical advice from your health care provider. These products are not intended to diagnose, treat, cure, or prevent any disease. Remove any oils or lotions that are on your skin as it can keep the patch from sticking properly. Dr Jan M Schilling reports grants from Verséa™ Pharmaceuticals, during the conduct of the study. Dr Michelle Sexton is a medical advisor for Verséa™ Pharmaceuticals and reports personal fees from Verséa™ Pharmaceuticals, outside the submitted work. Dr Backonja is a medical advisor as Medical Director for Verséa™ Pharmaceuticals. He also was supported by grants from Versea Holdings, LLC, during the conduct of the study. Little is known about how effectively CBD works in managing chronic pain, a condition characterized by discomfort that persists beyond 3-6 months or beyond expected normal healing. This article does not contain any studies with human or animal subjects performed by any of the authors. Dosing for symptom relief has not yet been established. The survey question regarding the knowledge of CBD dosing showed that almost all answer choices were represented as similar percentages, suggesting that there is a high variability of familiarity with CBD content in CBD products. Very similar percentages across possible answers were received pointing towards an overall unfamiliarity regarding knowledge of CBD content in used products. When asked if using a CBD product was able to reduce the amount of pain medication in general, the majority agreed (37.1%) or strongly agreed (30.5%). When asked what type of products they have used, the most frequent responses were inhaled/smoked (62.9%), edibles (54.3%), and oral tinctures (52.3%). No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. If you are taking other medications, it is particularly important to discuss with your health care professional before starting CBD. More research is needed to fully understand CBD's effectiveness for pain management. Look for oils that provide clear labeling, including the concentration of CBD, the type of carrier oil used, and any additional ingredients. Topical CBD creams and salves are popular choices, as they allow for targeted relief directly on the affected area. Furthermore, consider the type of CBD product broad-spectrum, full-spectrum, or isolate depending on your preferences and needs. A reputable product will provide a Certificate of Analysis, detailing the cannabinoid profile and confirming that it is free from harmful substances. It is essential to listen to your body and adjust the dosage accordingly, as some individuals may require higher amounts of CBD to relieve pain effectively. Melanocytes and pigmentation disorders With CBD, the average pain score was 2.76, representing an average decrease in intensity of 60%. Almost 70% of participants reported that their pain intensity was “much better” with CBD; an additional 23% reported it was “a little better.” Without CBD, the average pain score was 6.85. Most significant though was CBD’s impact on the intensity of pain. Just under 90% of participants reported some improvements in the frequency and duration of their pain, with 60% reporting that CBD made these aspects “much better.” Participants reported meaningful improvement against all pain measures. Still, many people like the longer wear time.She adds, “In functional medicine, we're focused on keeping our bodies free of toxins, so also ensure that your CBD product is meets limits for heavy metals, pesticides, and mold.Federally, hemp-derived CBD (with less than 0.3% THC) is legal in most states, but some places have local restrictions.Dr Jan M Schilling reports grants from Verséa™ Pharmaceuticals, during the conduct of the study.A low dose for pain relief was used for all studies reviewed and exhibited an average dose of 19.82 mg/day .By interacting with these receptors, the sensation of pain is reduced, similarly to how traditional pain management medications act, without the traditional side effects and negatives.CBD, or cannabidiol, is one of the many chemical compounds known as cannabinoids found in the cannabis plant.Researchers are studying how CBD might benefit people with cancer, schizophrenia, cognitive impairment, quitting smoking, bipolar depression, and more. Health & Medicine Together with the discovery of the cannabinoid receptors on the skin, it has been further illustrated that topical cannabis has anti-inflammatory, anti-itching, analgesics, wound healing and anti-proliferative effects on the skin. One study (in 2009) found that CBD may be more effective at treating neuropathic pain than opioids. Because of its role in treating chronic pain, depression, nausea and appetite issues, and even nerve pain, CBD may provide benefits to fibromyalgia sufferers as well. CBD is pulled from hemp, a type of cannabis plant that contains very low levels of THC, so it doesn’t get you high. CBD, or cannabidiol, is just one of more than 100 chemical compounds found in the cannabis sativa plant. We do not endorse non-Cleveland Clinic products or services. The product’s ingredients specifically target the joints to relieve arthritis-related pain and discomfort. At Northeast Spine and Sports Medicine, we understand the popularity of CBD for pain management, but we also realize cannabidiol extracts may not be an ideal choice for you. At least 2,800 people have been hospitalized and at least 68 people in the U.S. have died from lung injury linked to vape pens containing vitamin E acetate. Vaping CBD may be dangerous to your health. The vape pen heats a liquid containing CBD, usually diluted with palm, coconut, or vitamin E oil. The flowering heads of the hemp plant are known as CBD flower, or hemp flower. Most of the research done has suggested CBD may help with different types of pain.Taken together, participants report some perceived beneficial effects using CBM and CBD products including the reduction of pain medication.Still, current data is encouraging and experts believe CBD is a product worth paying attention to.As the World Health Organization reports, depression is the single largest disability-inducing factor worldwide, while anxiety problems score sixth place.Because the pathogenesis of psoriasis largely involves T-cell lymphocyte mediated immune properties and keratinocyte proliferation, cannabinoids are viewed as a subject of great interest in future modalities of treatment.20,21,22Many studies suggest CBD can provide real benefits, especially for chronic pain. Even states and territories of the U.S. differ on cannabis regulations, mainly because of the possible risks outweighing the benefits and the availability of pure CBD products. Hence, there is a limitation in conducting studies on CBD products. A systematic review of the efficacy and safety of pure CBD products was initially planned, but there are limited studies and articles available. However, more minor studies are focused on using pure CBD products, which are nonintoxicating. With so many options available, from pills to vaping, it's easy to find a way to incorporate CBD into your pain management routine. You can get CBD pills without a prescription, but the FDA has approved a cannabidiol prescription drug called Epidiolex for epilepsy patients. However, there may be a delay in symptom relief, as you have to wait until your body breaks down the capsule and distributes its contents. Chronic pain is defined as any pain lasting more than 12 weeks. Such insights are invaluable for fostering community engagement and can help others in their journey toward finding relief. Additionally, sharing your experiences with CBD—whether positive or negative—can contribute to a broader conversation about its use in pain management. However, it is essential to regard CBD not as a universal remedy but rather as a complementary approach to pain management. Throughout this discussion, we have examined what CBD is, how it functions within the body, and its possible applications in alleviating pain. Making informed choices about CBD can help you get the relief you’re seeking, while avoiding unwanted surprises and making your wellness journey a little easier. The FDA doesn’t fully regulate CBD for pain, so you want to stick with brands that value transparency and testing. Buying from a trustworthy source ensures your product is legal, safe, and contains what is on the label. Federally, hemp-derived CBD (with less than 0.3% THC) is legal in most states, but some places have local restrictions. CBD’s legal status in the United States depends on where you live and whether it’s made from hemp or marijuana. Inflammation is a central cause of pain in conditions like arthritis. Poor sleep and heightened anxiety can worsen pain, creating a difficult cycle. A comprehensive 2020 review in Frontiers in Pharmacology also analyzed numerous studies and found that CBD was consistently linked to significant pain reduction and improved quality of life in patients. Researchers conducted an anonymous survey of adults with chronic pain to understand its perceived effectiveness. A growing body of research suggests that CBD is a powerful, multi-faceted tool that can address not only pain itself but also its common companions, like anxiety and poor sleep. A prescription cannabidiol (CBD) oil is considered an effective anti-seizure medication. Medical scientists validate patient accounts of CBD and cannabis for symptom relief. Our natural relief solutions use premium hemp-extracted CBD alongside other helpful ingredients. More interestingly, people put under stressful situations may also experience a smaller rise in blood pressure than normal.Now that you understand the difference between the two sources of CBD oil, let’s talk about the benefits of CBD backed by scientific evidence.A study highlighting this was performed approximately one decade ago.The numbers are staggering, the research is ongoing, and early intervention and symptom identification education have grown in prevalence in order to increase heart health.This article cuts through hype to share what the latest science and real-world stories say about pain relief and CBD.Some people make their own edibles by adding food-grade CBD oil to brownies or cookie dough. Again, it’s best to speak with your doctor or healthcare provider before taking CBD if you have a medical condition. However full-spectrum hemp CBD products can have up to 0.3% THC per pound by dry weight. For the millions of people looking for a way to manage their pain without the risks of addiction and harmful side effects, CBD offers a non-habit-forming, plant-based solution. Just make sure the product underwent third-party testing from an accredited lab.CBD for chronic pain as an adjunct medication has gained popularity since it is easier to access and has less physician guidance.One question in Table 1 (“Did any of the CBD products you used contain THC (the chemical that gets you “high”?”) additionally needs clarification.CBD may inhibit certain enzymes responsible for drug metabolism, which could lead to increased effects or side effects of concurrent medications.The study’s authors concluded that these results highlight the necessity of more research into cannabis as a potential tool for harm reduction and as an alternative to prescription opioids for chronic pain.This product is not intended to diagnose, treat, cure, or prevent any disease.Up until December 2018, CBD was classified by the federal government as a Schedule I substance along with marijuana, making it extremely difficult to study. These two observational studies mentioned above hold decent evidence of the positive effect of CBD on chronic pain, like reduced opioid intake and improved sleep. The mixed (inhalation + non-inhalation) route is preferred (45% of respondents), and this is attributed to the tailored pain relief experienced . In an RCT done by Lichtman et al., nabiximols (THC+CBD) oromucosal spray was used as an adjunct treatment in 291 patients with advanced cancer and chronic pain on opioids . In addition, different routes of administration showed other forms of pain relief. The exclusion criteria included the presence of other cannabis components such as THC, systematic reviews, narrative reviews, meta-analyses, clinical cases, and articles not in English and/or Spanish. The search was not limited by the year of publication, due to the limited number of preclinical and clinical studies performed only with CBD as the major component. Of all of them, up to five studies observe positive effects and one of them does not have superiority to placebo, and in many cases the topical route is an effective way for the application of CBD. According to the quality of the studies assessed by the Jadad scale, there are eight clinical trials with the maximum score of 5 points. This makes it difficult to draw conclusions on the effect of CBD alone on chronic pain. The review concluded that CBD could help reduce pain and inflammation in conditions such as arthritis, multiple sclerosis, fibromyalgia, and neuropathic pain. A systematic review published in the journal Cureus analyzed multiple studies on CBD and pain management. It has been previously shown that non-psychotropic phytocannabinoids exert complex anti-acne effects by normalising ‘pro-acne agents’-induced excessive sebaceous lipid production, reducing proliferation and alleviating inflammation in human sebocytes. Cannabinol-based studies promise to be a key feature in literature and might lead to a breakthrough that will add a different dimension to how we see skin pathology treatment for a plethora of skin diseases (see Figure 1). Even more interesting, topical use of cannabis as a form of treatment covers a wider scope of skin disorders as highlighted in the discussion. The extent of the uptake varies widely with the physicochemical properties of the xenobiotic, the formulation and application of the product, and with skin conditions.7,8 Cannabis that has high levels of CBD, and very low insignificant levels of 9-THC, is referred to as ‘industrial hemp’, or ‘hemp’, and has no psychoactive effects.3,4 FDA regulation of CBD needs more clinical trials to determine its effectiveness and safety and should meet proper standards for authorization . Chronic pain is a continuous or recurring pain for three months or longer experienced by a patient due to various causes. CBD's medical value was a hot topic for debate before being recognized in the medical field. More clinical trials should be done to prove CBD's significance clinically and statistically. CBD can change how your body experiences pain and reacts to inflammation. Known as cannabinoids, CBD and delta-9-tetrahydrocannabinol (THC) are different chemicals found in cannabis. And, while there is a lot of positive talk about cannabis, there are risks—especially if you’re over 55. You can easily find CBD hemp oil in your local pharmacy, vape store, health retail center, as well as online. Hemp-derived CBD products are legal in all 50 states and can be sold over the counter along with other health supplements. CBD may help alleviate cancer-related symptoms and the side effects of cancer treatment, such as pain, nausea, and vomiting. Several human studies have linked CBD to positive effects in treating pain related to arthritis or multiple sclerosis. Chronic pain and emotional well-being are deeply intertwined. While research is ongoing, a compelling body of evidence highlights CBD’s potential as a safe and effective option for managing complex chronic conditions. Most people fall asleep within 10 to 20 minutes, but if your experience is different, adjusting your sleep schedule may help These recently popular drinks claim to relieve anxiety and stress, but more research is needed Trying CBD for pain isn’t like picking a simple over-the-counter remedy. While CBD alone delivers results for many, some find even more relief combining it with other cannabinoids (like THC). People often describe steady improvements in comfort, mobility, and quality of life when they find the right product and dose. Let’s pull together what the evidence says, highlight its effectiveness, and touch on what really matters for those exploring CBD for pain. Different types of chronic pain are identified based on their nature, location, and characteristics. In addition, dronabinol a synthetic delta-9-tetrahydrocannabinol (THC) product and nabilone (like THC) were regulated by the FDA for the treatment of chemotherapy-induced nausea and vomiting . According to Forbes, in October 2020, cannabidiol (CBD) sales in the United States reached $4.2 billion after the federal government legalized hemp-derived CBD in 2018 . Only one CBD product (Epidiolex, a medication that treats seizures) has been approved by the FDA. Here is a list of a few potential risks and side effects that come with CBD. According to the WHO’s Expert Committee on Drug Dependence (ECDD), people are unlikely to abuse pure CBD or be harmed by using it. More than 250 clinical trials on CBD benefits have been completed or are recruiting participants. A few studies have shown improvements in psychosis symptoms, sleep disorders, and quality of life. Another area of focus for CBD research has been around its impact on mental health. Now that we’ve established how CBD works within our bodies, let’s dig into what the research says about the possible effects and use cases for CBD. Medical cannabis expert and double-board certified doctor, Dave Gordon, M.D., agrees that CBD’s ability to influence the ECS is what makes it such a versatile tool. The two interact like a lock-and-key system, with cannabinoids binding to receptors and triggering widespread physiological effects. In other words, it helps us stay balanced across all major mental and physical functions, including pain, sleep, mood, stress, and even digestion. Several studies show the benefits of pure CBD may have wide-ranging positive effects, though. “There’s no oversight of the majority of CBD products from a regulatory authority,” says Dr. Terpeluk. It’s important to know that since the implementation of the 2018 Farm Bill, the production and sale of CBD products in the U.S. has been legalized on the federal level as long as they contain less than .3% of THC. CBD oil is simply a product that contains CBD extract and an oil, like coconut oil, typically for topical use. In one study from 2018, healthy people who took a single dose of CBD did not have any effects on their sleep. One study showed that people took fewer opioids for pain when they were treated with CBD-rich hemp extract. These products often make different health claims, such as helping you sleep, detoxifying your body, or relieving pain, but there isn't any research to support these claims. If you're interested in CBD treatment for chronic arthritis pain or if you're already taking it, review the pros, cons, and latest news with your healthcare providers, and together you can decide on a reasonable treatment plan. Thus, there is a physiological basis to investigate CBD for the treatment of pain. In addition to its effects on the ECS, CBD interacts with other important signaling systems involved in the regulation of pain. CBD for chronic pain as an adjunct medication has gained popularity since it is easier to access and has less physician guidance. Although CBD and THC come from the same cannabis plant and have almost identical chemical structures, they attach differently to a CB1 receptor, eliciting different effects.