To wrap it up, CBD and THC are different yet complementary compounds that can effectively support the functioning of your endocannabinoid system. Similar to how CBD can dampen the intoxication from THC, some of the effects of CBD are more pronounced when you add a little bit of THC to the mix. Still, even if you use a lab-tested full-spectrum CBD oil, you shouldn’t get a false-positive result for THC on a drug test unless you take around 1900 mg of CBD daily. But the question is, can you fail a drug test using full-spectrum CBD oil? To be precise, drug tests look for the metabolite of THC known as THC-COOH. But the evidence for CBD alone treating chronic pain is contentious. Both CBD and THC have historically been used to treat pain. Police use saliva analysis to determine whether someone has been drug driving. The most obvious side effect of THC use is also the reason a lot of people take it (at least recreationally), and that’s the drug’s ability to alter your senses. In many states and countries, THC is classified as a controlled substance due to its psychoactive properties. When exploring the distinctions between CBD and THC, understanding the legal status of these compounds is vital. This psychoactive element sets THC apart from CBD in terms of its recreational use. CBD is non-intoxicating and produces no euphoric or psychoactive properties. A new study from Georgia State University reveals that marijuana users may face a 3.42… It is crucial for individuals to stay informed about the specific laws and regulations governing CBD and THC in their jurisdiction, as the legal landscape continues to evolve. Anandamide, known as the “bliss” molecule, is routinely reabsorbed by the body. It also effectively mimics the effects of inhibitors like acetylsalicylic acid (Aspirin), ibuprofen, and naproxen. It does not bind with the CB1 and CB2 receptors in the same way as THC, but it appears to interfere with those molecules that do bother the receptors. When it binds to the CB1 receptors, it disrupts the flow and sends unconventional signals to the brain. Some users initially report not “feeling” anything from CBD, expecting marijuana-like obvious subjective changes, and may mistakenly conclude it does not work.Clients interested in exploring the benefits of cannabinoids should consider ARCannabisClinic for expert guidance on product selection and safe use practices.This means that CBD can never cause any intoxicating effects, no matter how much is consumed.Now that you know the basics of these two cannabinoids, let’s learn how cannabinoids interact with your body.The difference between CBD vs. THC is that the former offers a relaxing sensation to your body without producing a mellow physical high.THC and CBD together may relieve symptoms of chronic pain, nausea and vomiting, muscle spasms, and insomnia. CBD is the acronym for cannabidiol, a non-intoxicating cannabinoid synthesized by cannabis plants. We’ll also discuss the mechanisms both cannabinoids use to regulate essential processes in your body. CBD and THC have a similar molecular structure to the cannabinoids produced naturally in your body by the endocannabinoid system. THC binds more strongly to receptors, creating noticeable psychoactive effects. Though it's often well-tolerated, CBD can cause side effects, such as dry mouth, diarrhea, reduced appetite, drowsiness and fatigue. Food, drinks and beauty products are among the many CBD-infused products available online. However, further research is needed to determine CBD's other benefits and safety. Enjoy our safe mail-order marijuana service with cheap pricing, discreet packaging and fast delivery. Understanding the differences between THC and CBD can help you make the most out of your cannabis experience. THC has a low potential for addiction, but heavy use over time may lead to dependence in some individuals. THC, on the other hand, can impair driving and is illegal to use before operating a vehicle. THC can cause side effects such as impaired memory and concentration, dizziness, anxiety, paranoia, and increased heart rate. Hemp-derived CBD products containing less than 0.3% THC are federally legal in the United States, but state laws can vary. In states where marijuana is legal, the possession and use of THC may be permitted within the confines of the state's specific regulations, such as age restrictions, possession limits, and licensed dispensaries. It is classified as a Schedule I controlled substance under the Controlled Substances Act, indicating a high potential for abuse and no accepted medical use31. There is also a chance that, if you are taking blood thinning medication already, CBD could compete for the enzymes that break down the drugs. However, it – like just about all drugs – can impact people differently. Much of the reported benefits of THC (like CBD) is anecdotal, but there are reports that it can assist with things like muscle spasms, insomnia, glaucoma, and (much more obviously) low appetite. The “benefits” of THC use are sort of summarised by what you’re trying to achieve. A study published in the British Journal of Pharmacology found that CBD reduced anxiety produced by THC in human subjects, while not affecting THC euphoric effects, suggesting CBD can improve tolerability without eliminating desired therapeutic effects. This explains extensive research and anecdotal evidence showing CBD reduces THC-induced anxiety, paranoia, and cognitive impairment when the cannabinoids are co-administered. CBD acts as a negative allosteric modulator at CB1 cannabinoid receptors where THC produces intoxicating effects, meaning CBD binds to a different site on the receptor and changes its shape in ways that reduce THC binding and signaling efficiency. The interactions between these cannabinoids have important implications for product selection and optimal therapeutic approaches depending on individual goals and circumstances. For zero THC assurance, our CBD isolate and broad spectrum product lines eliminate drug testing risks while delivering quality therapeutic-grade CBD for wellness and health applications. CBD derived from marijuana is illegal federally but allowed under certain state statutes. Hemp-derived CBD products containing less than 0.3 percent THC are federally legal, but some state laws still prohibit them. Keep in mind that cannabinoids affect individuals differently. Clinical studies continue in the research field to optimize and further realize the full potential of CBD in medical applications. The endocannabinoid receptors in our body that bind with CBD are distributed throughout the nervous system and concentrated in the spleen. In terms of their health benefits, one of the main differences between THC and CBD is the parts of the body that they affect. Recreational users who prefer a more body-focused high can benefit from cannabis products containing CBD. And that’s why you’ll always hear people talking about CBD products when they’re using cannabis for health and wellness. Begin Your Search for Medical Cannabis Today However, the arrangement of these atoms differs slightly between the two compounds, which leads to their distinct effects on the human body7. It also has significant implications for the legal status and accessibility of CBD and THC products. Understanding these key differences is crucial for anyone considering using cannabis products for medicinal or recreational purposes. This makes CBD an attractive option for those seeking therapeutic benefits without psychoactive effects. The effects of CBD and THC on the body stem from their interaction with the endocannabinoid system, a complex network that regulates various functions like mood, pain, and appetite. The cannabis plant contains numerous chemical compounds known as cannabinoids, with CBD (cannabidiol) and THC (tetrahydrocannabinol) being the most well-known. While both originate from the cannabis plant, their effects on the human body can vary greatly. Mental Health Services in MA For more information on how ARCannabisClinic can assist you with medical cannabis, visit their website and explore the personalized support available through their MMJ Therapy Visit. They offer services such as obtaining a medical marijuana card and detailed consultations through their MMJ Therapy Visit, which includes strain, ratio, and dosing advice. The clinic is committed to staying informed on research and advancements, ensuring patients access the best cannabis strains and products. Individuals taking multiple medications should consult healthcare providers about potential CBD drug interactions before starting, particularly with medications metabolized by CYP450 liver enzymes. While CBD may not perfectly replicate all THC effects or benefits, it provides substantial therapeutic value for numerous conditions while remaining fully legal, non-intoxicating, and safe for regular use. While some jurisdictions have decriminalized small amounts of cannabis for personal use or legalized medical marijuana programs providing legal access for qualifying patients, recreational THC remains illegal throughout most of the UK and many countries worldwide. THC remains restricted to individuals with legal access through medical marijuana programs or recreational legalization in specific jurisdictions, and its intoxicating effects limit when it can be used safely. As the main psychoactive component of cannabis, THC is largely responsible for the cannabis high. In regular cannabis, CBD is the second most prevalent cannabinoid. It’s usually derived from hemp, a variety of cannabis with low THC levels (0.3% or less). Please consult a healthcare professional for any health concerns. THC can cause short-term effects like euphoria, anxiety, impaired coordination, and long-term psychiatric risks with heavy use, especially in adolescents. CBD usually comes from hemp, but it can also come from marijuana plants. As of April 2023, 38 states, three U.S. territories, and the District of Columbia have legalized medical marijuana. One study compared medical marijuana, CBD, and a placebo (fake treatment) for treating anxiety in veterans with PTSD. ” Pharmacotherapy (2020) – Analysis of synergistic effects between CBD and THC in clinical settings. Alchemy offers a diverse selection of products, including CBD flowers, oils, and cosmetics. For those seeking wellness improvements through either medical or recreational avenues, both CBD and THC present optimistic opportunities for enhancing overall quality of life. What is the legal status of CBD in the United States? It interacts with the body's endocannabinoid system, targeting cannabinoid receptors, and may provide similar effects to THC without psychoactive properties, as supported by recent studies. Understanding these differences is crucial, particularly when considering the legal status and potential side effects of cannabis products. Each of them has unique health benefits, but when used together, they allow you to revel in the full therapeutic potential of cannabis. These practical limitations restrict when and where THC-containing products can be safely and legally used, significantly limiting accessibility for many individuals compared to non-intoxicating alternatives. Pain gradually decreases, anxiety feels more manageable, sleep improves over time, but without the obvious acute intoxication that clearly signals a drug has taken effect. However, CBD therapeutic benefits often manifest as absence or reduction of negative symptoms rather than presence of noticeable positive sensations. The World Health Organization concluded in its extensive CBD review that CBD exhibits no effects indicative of abuse or dependence potential and is generally well tolerated with a good safety profile. A balanced approach using low-dose THC with CBD can help maximize benefits while minimizing unwanted psychoactive effects. While THC is best known for its psychoactive properties and ability to alleviate pain and nausea, CBD offers a non-intoxicating alternative for anxiety, inflammation, and neurological conditions. THC is primarily known for its psychoactive properties, while CBD provides therapeutic benefits without intoxication. Understanding these differences can help consumers and healthcare providers determine which cannabinoid or combination is best suited for specific health goals. Chronic pain relief is the most common reason people turn to CBD and THC-containing products. Keep in mind that cannabis laws are always changing and it’s likely to become legal in more states as time goes on. This means both THC and CBD sourced from marijuana are illegal, except for the growing number of states that allow for recreational marijuana use, such as Colorado and California. Hemp-derived CBD is federally legal thanks to the 2018 Farm Bill, which legalized hemp and once again turned it into an agricultural commodity after decades of prohibition. Out of more than 100 compounds in the cannabis plant, phytocannabinoids, such as THC, CBD, and cannabinol (CBN), were the first ones to be identified and isolated.1,2 Basically, there’s two important receptors in the human body relevant to cannabinoids, CB1 and CB2. Cannabidiol, or CBD, is the other major cannabinoid out of 113 known cannabinoids found in the cannabis plant. Tetrahydrocannabinol, also known as THC, is one of an estimated 400 cannabinoids, found in the cannabis plant, and is primarily responsible for the euphoric or “high” effect felt by users. These THC-free options allow access to cannabinoid wellness and therapeutic applications while maintaining career security and compliance with testing requirements. The mere risk of positive results makes full spectrum CBD products problematic for anyone subject to drug testing. The unpredictability of whether full spectrum CBD use will trigger positive results depends on individual metabolism, product THC content, frequency and dose of use, and drug test sensitivity, making outcomes uncertain and potentially risky for individuals who cannot afford positive results. A review is underway that could change how marijuana is classified under federal law. But as far as the federal government is concerned, it's still illegal in the U.S. Another study found that lower doses of THC appear to decrease anxiety in some users, but higher doses can make other users more anxious. But the benefits for those who got THC or CBD were no better than for those who got neither. A small study did find that participants who used CBD had improved sleep and anxiety, but a larger study is needed to confirm the findings. In individuals with Parkinson’s disease, cannabinoid-based treatments have yielded positive outcomes by improving motor functions while diminishing dyskinesia symptoms related to therapy sessions. Two other drugs that the FDA has approved — Dronabinol and nabilone — are effective against nausea caused by chemotherapy treatments. The safety considerations of CBD and THC play a vital role in their medical applications. Determining the ideal choice hinges on personal health goals and tastes along with consideration for any specific medical issues that are being addressed. Navigating the selection of an appropriate cannabis product requires careful examination of factors like the THC/CBD balance, your preferred method of intake, and seeking advice from medical experts. Various cannabis product types including edibles, tinctures, and concentrates offer users differing timescales for onset of effects as well as varying durations. This expeditious effect onset contributes to its popularity among those using cannabis for both therapeutic purposes and recreational enjoyment. To identify which method aligns best with specific health requirements, individuals should seek advice from medical experts. The body naturally synthesizes its own cannabinoids, called endocannabinoids. THC and CBD, like all cannabinoids, interact with the body through the endocannabinoid system (ECS). The legal status of THC products differ from state to state, but THC and marijuana are still illegal federally controlled substances. THC is a compound found most prominently in marijuana plants and is responsible for the euphoric effects that people experience when they ingest or smoke marijuana. CBD is a compound typically found in hemp plants, and it is most commonly used to produce CBD hemp oil products. Its biggest strength is how subtly it works in the background to help restore your body’s balance. Its sweet spot tends to be conditions related to inflammation, anxiety, and certain neurological issues. When you get down to the practical differences between CBD and THC, their medical uses are where things get really interesting. You can dive deeper into how these aromatic molecules fine-tune your experience in our detailed cannabis terpene guide. They aren’t trying to get high; they just want to support their body’s recovery so they can get back out there tomorrow, clear-headed and ready to go. However, when you hear people talking about CBD, they usually praise it for health and wellness rather than recreational use.CBD and THC share identical molecular structures (21 carbon atoms, 30 hydrogen atoms, and 2 oxygen atoms), yet their effects on the human brain differ significantly.These receptors are responsible for the anti-inflammatory effects of CBD.They play a significant role in memory, sleep, mood, appetite, pain sensation, and more.One study compared medical marijuana, CBD, and a placebo (fake treatment) for treating anxiety in veterans with PTSD.Explore our comprehensive CBD oil benefits guide to understand the full range of conditions potentially helped by CBD supplementation without intoxication.Discover how cannabinoids like CBD, THC, and terpenes work together to amplify therapeutic effects.The statements made regarding these products have not been evaluated by the Food and Drug Administration. The legal differences between CBD and THC is one of the most important things for people to know. Some people can build up a resistance to THC over time, which means they may need more of it over time to get the same effects. For example, some users like products that have small amounts of both CBD and THC because they think the mix makes the effect more balanced. In some regions, individuals also consume THC products for targeted personal wellness routines. Tetrahydrocannabinol (THC) is the primary psychoactive compound found in the cannabis plant.WebMD (2024) notes that this indirect interaction allows CBD to regulate how the body’s own cannabinoids, called endocannabinoids, function without overstimulating the brain’s reward pathways.CBD is predominantly extracted from hemp, which contains minimal THC.CBD treats similar ailments such as pain, anxiety, nausea and it also helps with regulating sleep.” Pharmacotherapy (2020) – Analysis of synergistic effects between CBD and THC in clinical settings.CBD is most commonly taken as sublingual CBD oil, although capsules, gummies, and other products are also used.Both THC and CBD interact with your body’s endocannabinoid system (ECS), but that interaction elicits very different natural effects.While THC isn’t fully legal in many places, CBD remains in the grey area of the law.Cannabidiol, or CBD, is the other major cannabinoid out of 113 known cannabinoids found in the cannabis plant. Choosing between the two, or using them in combination, depends on individual health needs and the desired therapeutic outcome. Many conditions benefit from a combined approach, as the cannabinoids complement each other. Cannabis contains over 100 naturally occurring compounds called cannabinoids, with tetrahydrocannabinol (THC) and cannabidiol (CBD) being the two most well-known. The statements made regarding cannabis products on this website have not been evaluated by the Food and Drug Administration (FDA). Also remember that nonprescription CBD products are not FDA-approved and labels may be inaccurate. Some people may experience benefits for the conditions listed above while others may not. Although both interact with the endocannabinoid system, their outcomes for users can be very different. While both CBD and THC are generally considered safe, they can cause side effects, which vary in severity and prevalence. It is important to note that while both CBD and THC show promise in various medical applications, more research is needed to fully understand their efficacy, optimal dosing, and long-term safety. However, their distinct pharmacological properties and interaction with the endocannabinoid system result in different applications and efficacy for specific ailments. Anandamide is known as the "bliss molecule" and is involved in regulating mood, pain, and appetite12. Coronavirus anxiety is not an uncommon phenomenon. Although the Cannabis industry and its legality are ever-changing, and we can’t guarantee that the answers will remain the same. While THC isn’t fully legal in many places, CBD remains in the grey area of the law. Both CBD and THC hold considerable potential in managing various ailments, including chronic pain and neurological diseases. While THC has more noticeable immediate effects, CBD provides a gentler impact on neurologic functions but can be just as advantageous therapeutically. Instead, CBD primarily interacts with serotonin receptors rather than CB1 receptors, influencing mood and pain regulation without causing cognitive or motor impairment. CBD, THC, and whole-plant cannabis are not currently approved for any medical condition. Research has shown that CBD and THC have a wide range of potential health benefits, many of which are similar. Additionally, medical marijuana is legal in most states. It comes from the cannabis plant, which makes a thick substance full of compounds called cannabinoids. Studies indicate CBD may enhance THC analgesic effects for pain relief while reducing cognitive impairment, increase THC anti-inflammatory effects while reducing anxiety, and extend duration of THC therapeutic effects through effects on metabolism. Research suggests that CBD may enhance some beneficial THC effects while reducing side effects, potentially improving the overall therapeutic index meaning the ratio of therapeutic benefits to unwanted effects. These products provide predominantly CBD effects with potentially enhanced benefits from small THC amounts contributing to entourage effects without producing noticeable intoxication or impairment. Many medical marijuana patients report better symptom relief with more tolerable side effects from balanced products compared to high-THC alternatives. “We should be thinking of cannabis as a medicine first,” said Dr. Tod Mikuriya, “that happens to have some psychoactive properties, as many medicines do, rather than as an intoxicant that happens to have a few therapeutic properties on the side.” The euphoric qualities of cannabis, far from being an unwholesome side effect, are deeply implicated in the therapeutic value of the plant. Big Pharma is keen on synthesizing medically active marijuana-like molecules that don’t make people high—although it’s not obvious why mild euphoric feelings are intrinsically negative for a sick person or a healthy person, for that matter. Ongoing studies suggest CBD could complement standard treatments for chronic pain relief, neuropathy, and inflammatory conditions like arthritis. Because it shows very little affinity for CB1 receptors, it delivers relaxation without intoxication. CBD is the soothing counterbalance in the cannabis lineup. Understanding this distinction makes it easier to choose cannabis strains that match your goals. In a nutshell, THC is psychoactive, while CBD is non‑psychoactive. Uncle Sam’s single-molecule blinders reflect a cultural and political bias that privileges Big Pharma products. And extensive clinical research has demonstrated that CBD combined with THC is more beneficial for neuropathic pain than either compound as a single molecule. THC and CBD are the power couple of cannabis compounds—they work best together. The same CBD-activating receptors also trigger the endocannabinoid’s response. Endocannabinoids keep memory, mood and energy balances inside optimal parameters. The medical community is only now discovering the huge variety of benefits of CBD. The exception here is the ACT, where residents over the age of 18 are able to possess up to 50 grams of dried cannabis or 150 grams of fresh cannabis, grow up to two plants per person, and use cannabis at home. The primary psychoactive component of cannabis, THC is what gets you there and keeps you there. When you think “medical marijuana” or any of the terminology along those lines, CBD is probably the component on your mind. CBD is talked about inside and outside cannabis-advocate circles for the variety of health issues it eases. Cannabidiol (CBD) is one of more than a hundred components in the hemp plant. Some people also report CBD assisting with certain sleep disorders, and there is encouraging data surrounding the drug’s use to treat migraines. That could be in relieving pain, or relief and alleviation of some cancer-related symptoms. CBD benefits that are often reported by patients are regularly focused around “relief”. If you want to get your hands on medicinal cannabis, you need to speak with a registered and authorised practitioner, and approvals are handled on a case-by-case basis. Medical cannabis, which is often heavily CBD-dosed or a combination of both CBD and THC, is a different story. 'Epidemiology of anxiety disorders in the 21st century' If you’re looking for CBD products, we’re here to help your searching. It has great health properties and doesn’t affect your ability to concentrate, nor makes you impaired as THC does. Things You Need to Stop Doing If You’re a Pisces Athletes using full spectrum CBD products containing trace THC or other cannabinoids risk positive drug tests resulting in competition bans, medal forfeiture, and career damage. Broad spectrum CBD with THC completely removed or pure CBD isolate products provide safe alternatives that deliver therapeutic CBD benefits without drug testing risks. Explaining that positive results came from legal hemp CBD products rather than marijuana may not prevent negative consequences if policies prohibit any detectable THC regardless of source or amount. For those navigating the complexities of cannabis laws, ARCannabisClinic offers invaluable resources. Understanding the legal status of CBD and THC can be tricky, given the different rules across the United States. It's essential to consider the legal status of THC, as it varies under state laws and federal law. But, in high doses, THC may lead to psychotic symptoms, increased heart rate, and potential dependency issues. CBD use may help reduce cognitive impairment by interacting with the body’s endocannabinoid system, potentially enhancing brain function through neuroprotective effects. CBD use for chronic pain offers potential therapeutic effects, including pain relief, reduced inflammation, and improved sleep quality. Federal law regulates cannabis products under the Controlled Substances Act, classifying marijuana plants and THC products as Schedule I controlled substances, restricting their use. THC causes psychoactive effects, while CBD offers therapeutic effects without the high, impacting medical conditions. That said, current evidence does not conclusively show that cannabis use directly causes psychiatric disorders such as schizophrenia. Chronic cannabis use can contribute to an amotivational state characterized by depressive symptoms and reduced drive. Reported adverse effects are often due to interactions between CBD and other medications, and in some cases may include liver injury. Evidence also supports that a combination of THC and CBD may be most beneficial for pain management. Both cannabinoids start as cannabigerolic acid (CBGA).CBD barely nudges CB1, so it stays non-intoxicating while offering anti-inflammatory, anti-anxiety, and seizure-reducing benefits.As it's still a Schedule I drug, scientists must follow DEA rules or face fines.Both substances have invaluable and promising medical applications.A small study did find that participants who used CBD had improved sleep and anxiety, but a larger study is needed to confirm the findings.Check out our blog if you’d like to learn more about cannabis CBD vs hemp CBD.CBD usually comes from hemp, but it can also come from marijuana plants. Multiple clinical trials demonstrate CBD anxiolytic effects without causing sedation or cognitive impairment, making it suitable for daytime use. CBD shows particularly strong evidence and common usage for anxiety disorders including generalized anxiety disorder, social anxiety disorder, panic disorder, and PTSD. Both demonstrate neuroprotective properties potentially benefiting neurodegenerative conditions like Alzheimer disease, Parkinsons disease, and multiple sclerosis. THC engages with CB1 receptors in the brain, altering cognitive processes and emotional states. In contrast, CBD is considered to be non-psychoactive as it does not create a high sensation. CBD and THC share identical molecular structures (21 carbon atoms, 30 hydrogen atoms, and 2 oxygen atoms), yet their effects on the human brain differ significantly. This sensation stems chiefly from THC’s interaction with CB1 receptors in the brain, altering emotions and sensory experiences. THC is widely recognized for its capacity to induce an intoxicating high that is favored among users of recreational cannabis. Two notable naturally occurring compounds in plants from the Cannabis genus are cannabidiol (CBD) and tetrahydrocannabinol (THC). The primary distinction is that THC causes a psychoactive “high,” whereas CBD does not. These products should never be administered to children without a physicians advice. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Understanding the Cannabis Plant Instead, it’s known for its calming and therapeutic effects.When it comes to their use, bot cannabinoids have several recreational and medical benefits.In particularly strong strains, effects can hit within 10 minutes.Both CBD and THC come from the cannabis plant, but their legal status can vary significantly.Higher THC concentrations increase the psychoactive effects due to greater interaction with cannabinoid receptors in the brain, potentially causing cognitive impairment, psychotic symptoms, and altered brain function.I'm glad cbd is not intoxicating, I'm looking for a cure to chronic pain, highly interested. For individuals seeking more substantial interactions between cannabinoids for therapeutic purposes, this requires access to medical or recreational marijuana products with higher THC levels in jurisdictions where legal. While both are cannabinoids derived from the cannabis plant, they have distinct properties, effects, and legal considerations. It is one of over 100 cannabinoids identified in cannabis, and it has gained significant attention for its potential health benefits. According to the federal government, specific components of the marijuana plant (THC, CBD) have medical value, but the plant itself does not have medical value. Project CBD categorically rejects this moralistic, reefer madness dichotomy in favor of whole-plant cannabis therapeutics. Diehard marijuana prohibitionists are exploiting the good news about CBD to further stigmatize high-THC cannabis, casting tetrahydrocannabinol as the bad cannabinoid, whereas CBD is framed as the good cannabinoid. In conclusion, the cannabis plant is a complex species that contains over 100 different compounds known as cannabinoids. To summarize, the two primary compounds of interest in the cannabis plant, CBD and THC, provide distinct yet synergistic health benefits. These findings underscore the significant therapeutic capabilities of cannabinoids like CBD and THC across diverse health conditions. Investigations into cannabinoids have shown they could potentially stimulate appetite in patients grappling with HIV/AIDS-induced anorexia, presenting a significant therapeutic avenue. CBD suits daily balance and mild-to-moderate discomfort; THC may aid severe pain (where legal). Understanding their differences and the unique role THC plays in the entourage effect allows you to make choices that align with your health goals, legal boundaries, and lifestyle needs. Some states allow only THC-free CBD products, while others regulate or restrict even hemp-derived CBD. The entourage effect describes how cannabinoids and terpenes work better together than alone. Medical Marijuana and CBD vs THC Udoh M, Santiago M, Devenish S, McGregor IS, Connor M. Cannabichromene is a cannabinoid CB(2) receptor agonist. Marijuana, cannabis, and public opinion. A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae). U.S. laws surrounding cannabis are continually changing. Although their chemical formulas are similar, CBD and THC differ in psychoactive properties. A minor variation in the arrangement of these atoms explains why they affect the body differently. CBD does not create the intoxicating “high” linked to cannabis use. CBD products are marketed as gels, gummies, oils, supplements, extracts, and more. The chances of experiencing any negative side effects with it are low, making it a safe solution. When you push a component like THC too high, or isolate a component like CBD at the other components’ expense, you can reduce their beneficial effects. Synergy is when two or more substances or other agents interact and cooperate to produce a combined effect that’s greater than the sum of their separate effects. However, combine the both of them and you instantly have a whole range of new therapies and effects available to you. For instance, CBD mitigates psychosis symptoms while THC is the perfect therapy for chronic pain. THC isn’t the only cannabinoid that produces those effects, but it is the only one that exists in significant enough quantities in cannabis products to get a consumer high. Second, CBD is responsible for many of the significant medical and therapeutic benefits of cannabis. Cannabidiol, or CBD, was one of the first cannabinoids scientists discovered and is, today, one of the most researched compounds in the cannabis plant. While there are similarities between the two cannabinoids, clear distinctions do exist — including how they’re used and the nuances of their psychoactive effects. Your brain’s cannabinoid receptors work with your body’s naturally-occurring endogenous cannabinoids. It’s also worth noting that other compounds in cannabis, called terpenes, play a big role in the final effects of both THC and CBD. This is where the rubber meets the road, and understanding the real-world effects is key to choosing the right cannabinoid for you. This indirect approach is why CBD is linked to wellness benefits like easing anxiety and reducing inflammation, but without the high. Cannabinoids mimic neurotransmitters and stimulate their production and this way help the endocannabinoid systems function better. Us, humans, have endocannabinoid systems. Cannabis is a sun-loving annual plant that thrives under a variety conditions. That tiny variation is exactly why THC binds so well to CB1 receptors and CBD doesn’t. For a closer look at this crucial network, check out our guide on how the endocannabinoid system works. Why do two compounds from the same plant, with nearly identical chemical makeup, create such wildly different experiences? Choosing the Right Cannabis Products THC may be more effective for chronic or nerve pain. Let’s dive into some additional facts that help us better understand their roles in the cannabis world. Let’s explore some of the most popular and effective ways to enjoy cannabis safely and mindfully. Let’s take a closer look at how each cannabinoid interacts with our bodies to promote wellness and what to watch out for. Relying mostly on anecdotal history, it has made broad medical claims for decades.We’ve already talked briefly about the plant in this CBD vs THC guide.CBD is the non-psychoactive counterpart to THC.Or will it be CBD, the newcomer surging in popularity due to its wide-ranging health and wellness benefits?This means that CBD may suppress the CB1 and CB2 activating qualities of other cannabinoids.THC, on the other hand, binds directly to CB1 receptors in the brain, triggering euphoria and altering perception.Understanding these differences is crucial for anyone considering using cannabis products for medicinal or recreational purposes. Both CBD and THC are also used in capsules, edibles, tinctures, vape products, concentrates, topical preparations, and other products. Similarly, the pharmaceutical CBD drug Epidiolex is used for treating severe types of childhood epilepsy. THC is most commonly used in the form of dried marijuana. This may explain why cannabis strains high in CBD are less intoxicating. These products are not to diagnose, treat, cure or prevent any disease. The efficacy of these products has not been confirmed by FDA-approved research. The statements made regarding these products have not been evaluated by the Food and Drug Administration. Start with CBD (broad spectrum if drug testing matters), low dose, increase gradually, and review COAs. CBD alone won’t show up on a drug test because these tests are interested only in detecting intoxicating substances, including THC. The laws around THC and marijuana are harsh in most countries in the world. Hemp-derived CBD is legal in all 50 states because it meets the conditions set out by the 2018 Farm Bill. However, THC can also lead to a huge appetite boost; whether you consider this a negative effect or not depends on your relationship with food and overall physical health (3). That being said, CBD may cause drug interactions by preventing your liver from metabolizing most pharmaceutical medications (2). Sometimes people think CBD is not psychoactive, but it’s actually the opposite. Sign up for exclusive access to special offers, new products, and dispensary deals sent directly to your inbox. Medical cannabis requires a physician who usually prescribes or recommends it as a treatment option. It is through these interactions that CBD and THC augment the endocannabinoid system and encourage balance. Despite their similarities, tetrahydrocannabinol and cannabidiol have distinct differences in the way that they affect the endocannabinoid system. They are created in response to needs within the larger physiological system and are largely understood to be used for the body’s regulatory functions. The ECS is a signaling system in the body responsible for regulating a wide array of functions. Nonetheless, it’s best to talk to your doctor before using CBD, THC, or any other cannabis product. However, these effects seem to require large doses and are not well-studied in humans. Lastly, both CBD and THC can potentially interact with prescription medications. However, these side effects are mostly minor and were only found in studies using large oral doses of pure CBD. CBD alone is primarily used for medicinal purposes and does not have the potential to cause addiction or substance abuse. The main difference between CBD and THC is that, unlike THC, CBD does not have psychoactive properties and does not cause a high. American Marijuana doesn’t offer medical advice and the content accessed on this site is not intended for medical advice, diagnosis, or treatments, and has not been evaluated by the FDA. He’s also written third-party lab test reports of CBD products and knows the industry inside and out. It is a natural, plant-based alternative intervention strategy that can be helpful in restoring balance to the body and immune system. Pregnant and lactating women should use caution with CBD products as there is insufficient data on its long term effects. Please consult your health care professional about potential interactions or other possible complications before using any product. Always consult a qualified healthcare professional before beginning any supplement. Actually, THC, “The High Causer,” has awesome therapeutic properties. What is the difference between CBD and THC, the two most widely-studied compounds found in cannabis? But while THC can be abused as a drug, CBD does not have recreational applications. Both substances have invaluable and promising medical applications. The CBD vs THC debate is something that often crops up in the circles of cannabis users, and it mainly stems from misinformation that surrounds these substances. Hemp specifically means cannabis plants containing 0.3 percent THC or less and is federally legal in the US following the 2018 Farm Bill. Hemp plants, legally defined as cannabis containing 0.3 percent THC or less by dry weight, typically produce high CBD levels with minimal THC. The best option is to consult with a healthcare professional, discuss your issues, and go from there The drug is legally accessible in Australia, and the pathways are there. THC and CBD are often used in combination to enhance each other’s effects through a phenomenon called the “entourage effect”. CBD is generally well-tolerated, though some people may experience mild side effects like fatigue, dry mouth, or changes in appetite. CBD is the non-psychoactive counterpart to THC. In this blog, we’ll break down what sets THC and CBD apart to help you make informed decisions about your cannabis experience. However, it – like just about all drugs – can impact people differently.Please consult a healthcare professional for any health concerns.Dr. Michael Olla is a renowned medical professional licensed in both New York and New Jersey, specializing in psychiatry and addiction treatment.The difference in effects of CBD and THC influences how each compound is used for pain, anxiety, and recovery support.As laws around hemp and other cannabis products expand across the United States, more people are exploring their choices.Nevertheless, CBD has a lot of documented therapeutic benefits as well.Hemp-derived products are legal in all 50 states as long as they contain less than 0.3% of THC — which isn’t enough to get anyone high but still evokes the entourage effect.Instead, hemp naturally has more CBD compared to THC, making it an ideal source of CBD from cannabis. When it comes to their use, bot cannabinoids have several recreational and medical benefits. CBD and THC are two very different cannabinoids that come from the same plant but have different chemistry and effects. The ongoing research into cannabinoids continues to uncover new therapeutic potentials, paving the way for innovative treatments and improved quality of life. Cannabidiol (CBD) is a non-intoxicating compound found in cannabis plants, renowned for its therapeutic potential. We do not make or support any medical claims relating to the use of cannabis products to treat sleep problems, anxiety issues, or any other indication not approved by the FDA. While CBD should not have any intoxicating or psychoactive effects, it is important to note that CBD’s influence on the endocannabinoid system and other receptor systems within the body tends to affect people differently. As of 2024, recreational marijuana is legal in over 20 US states, medical marijuana programs exist in over 35 states, but marijuana including THC remains completely illegal in remaining states and under federal law. Federally, hemp-derived CBD became legal nationwide following the 2018 Farm Bill that removed hemp from the Controlled Substances Act, provided products contain no more than 0.3 percent THC. This illegal status creates significant barriers and risks for individuals who might potentially benefit from THC therapeutic properties but cannot access it legally or safely. As two of the main cannabinoids found in cannabis, you’d be right in assuming that CBD and THC are similar. Negative psychoactive effects include anxiety, lethargy, and short-term memory loss. This is why hemp-derived CBD products are now legally sold in all 50 U.S. states. Together, cannabis’ compounds can create positive effects that are potentially impossible for any compound to do alone. When it comes to the euphoric effects of cannabis, we must focus on the CB1 receptors concentrated in the nervous system and brain. Biosynthesis and Pharmacology of Phytocannabinoids and Related Chemical Constituents. Patients are left on their own to guess at the content and quality of non–FDA-approved cannabinoid products.22-24 This misinterpretation could lead to products being sold with high levels of THC – as much as 81 mg of THC in a single 30-mL bottle of hemp-derived CBD oil.30 While the 2018 Agriculture Improvement Act stipulates that hemp-derived products can have no more than 0.3% THC by dry weight,28 some purveyors are interpreting this to apply to finished product. On the other hand, Tetrahydrocannabinol (THC) predominantly targets CB1 receptors located in the brain. To completely comprehend the impact of CBD and THC and verify their effectiveness for various medical purposes, additional research along with clinical studies is crucial. There is evidence suggesting that CBD can have a positive effect on immune system functionality, thereby adding to its allure as a therapeutic agent. When comparing CBD and THC, one of the key distinctions lies in their psychoactive effects. However, the legal status of CBD products can vary from state to state, so it’s essential to check local regulations. In the United States, the legal status of CBD derived from hemp (containing less than 0.3% THC) was clarified under the 2018 Farm Bill, making it federally legal. One of the key characteristics of CBD is its interaction with the endocannabinoid system in the body, which plays a crucial role in regulating various physiological processes. Investigations into the realm of cannabinoids have paved the way for cutting-edge therapeutic interventions applicable to an array of medical conditions. Because of how it interacts with serotonin receptors, CBD could improve mood and alleviate anxiety – offering potential as a treatment option for different mental health issues. CBD can actually moderate THC’s psychoactive effects, potentially reducing negative effects like paranoia and anxiety. The differing psychoactive attributes between CBD and THC underscore their separate applications within medical treatment and leisurely consumption of cannabis products. The use of THC carries substantial hazards, especially for young individuals and those with pre-existing mental health conditions. Additional typical side effects include alterations in appetite and feelings of tiredness. It can cause some mild adverse effects including dry mouth, diarrhea, reduced appetite, drowsiness, and fatigue. These substances can interfere with other medications a person might be taking as well as various physiological processes in the body, sometimes resulting in unfavorable reactions. Both CBD and THC have shown potential therapeutic benefits for a wide range of medical conditions. While CBD does interact with the endocannabinoid system, it has a low affinity for CB1 receptors and does not cause the same psychoactive effects as THC5. This interaction with the ECS is believed to be the basis for CBD's potential therapeutic effects on the body and mind. Both cannabinoids come from the cannabis plant, but their primary sources differ. The difference between CBD and THC lies in their chemical structure and interaction with the body’s endocannabinoid system, producing distinct effects on mood, pain, and cognition. The intensity and duration of THC effects depend on dose, route of administration, individual tolerance, and other factors. Mayo Clinic does not endorse companies or products. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Cannabis plant compounds like THC and CBD interact with the body's endocannabinoid system by binding to cannabinoid receptors, potentially influencing brain function, immune response, and pain relief. Drug interactions are possible with both cannabinoids, so it is wise to consult a healthcare provider before starting any new cannabis products for medicinal purposes. These components interact with the body’s endocannabinoid system, offering potential benefits for various medical conditions, such as chronic pain and neuropathic pain. While both cannabinoids offer therapeutic benefits, their effects on the body are quite different. Out of 113 clearly identified cannabinoids, THC and CBD are some of the most common. Both belong to a special group of compounds called “cannabinoids.” One of them gets you “high,” while the other is non-psychoactive and used for therapeutic purposes, so it’s good to know which one you’re getting. Whether you’re seeking relaxation, pain relief, or just exploring the world of cannabis, there’s a product tailored to your needs. However, it’s always best to consult a healthcare provider, especially if you’re on other medications. It influences other receptors and enzymes to help bring the body back into balance, all without causing impairment. This one structural difference is the key to understanding how each one interacts with your body’s endocannabinoid system. It’s a handy cheat sheet for understanding how these two cannabinoids stack up on the factors that matter most. When researching the world of cannabis, it’s crucial to understand how THC and CBD affect our health. CBD, mainly when derived from hemp, is federally legal in the U.S. as long as it contains less than 0.3% THC. Instead, it’s known for its calming and therapeutic effects. THC (tetrahydrocannabinol) is the psychoactive component of cannabis. Among the 100+ cannabinoids out there, THC and CBD are the most famous. Cannabis drug tests look for the metabolites of THC, which means that using marijuana and other THC-rich products will likely result in a positive test. CBD is also used as part of whole-plant marijuana because it’s usually the second-most common cannabinoid in the plant after THC. However, it’s better known for its psychoactive side effects, such as anxiety, paranoia, and impaired memory and concentration. Through a phenomenon known as the entourage effect, CBD and THC enhance each other’s therapeutic benefits by working together synergistically. Such benefits underscore its potential utility as an essential supplement for wellness. The employment of CBD has been shown to offer considerable advantages, including alleviating pain, diminishing anxiety levels, and enhancing the quality of sleep. Our comprehensive CBD dosage guide helps newcomers identify appropriate starting doses and systematically optimize their regimen for desired therapeutic benefits within full legal compliance. This ease of access allows people to try CBD for various wellness applications or health conditions without navigating complex legal systems, obtaining medical documentation, or accepting legal risks. These legal complexities and risks make THC accessibility and use significantly more complicated compared to legally compliant hemp-derived CBD products that face no such restrictions. CB1 receptors cluster in the brain and central nervous system, while CB2 receptors are in the immune system and peripheral tissues. This small change affects the way each compound interacts with your endocannabinoid system (ECS), leading to very different experiences. Both THC and CBD share the molecular formula C₂₁H₃₀O₂, but one difference in atomic arrangement affects how they work in your body. Get a blueprint for navigating strains, products, and dosing with confidence. Following a landmark 2020 decision, cannabis was removed from Schedule IV of the 1961 Convention, acknowledging its potential therapeutic benefits. In an indicator of growing recognition for its therapeutic promise, by 2024 hemp-derived medical cannabis has been sanctioned in 47 states within the U.S. The use of medical marijuana is often regulated by local laws and requires a recommendation or prescription from a healthcare professional. Prescription access is an option in Australia — and rates of legal access are increasing across the country — but in many ways cannabis remains (at least in the eyes of police and the law) an illegal drug. There are multiple ongoing movements across the country, pressuring both police forces and governments, to amend drug driving laws to allow for legal medical users to drive without risk of punishment. Researchers are constantly looking into cannabis’ impact on the body and mind, but recent studies have shown that at the very least, ingestion of THC – consistently – as a teenager increases the chance of side effects. CBD also acts to suppress the CB1-activating qualities of compounds like THC, meaning that by using CBD and THC in conjunction, the psychoactive properties of THC may be lessened. This means that CBD can never cause any intoxicating effects, no matter how much is consumed. CBD doesn’t bind with CB1 receptors and is actually considered an antagonist of CB1 agonists. Instead, it acts as an indirect antagonist of cannabinoid agonists. Despite THC binding with both CB1 and CB2, the chemical compound tends to have a higher affinity for CB1 receptors. They produce different effects, with THC having psychoactive properties, while CBD use is linked to potential benefits without psychoactive effects. These effects vary based on the individual's tolerance, method of drug administration, and specific cannabis products used. State laws in the United States vary greatly; some allow both medical marijuana and recreational use, others permit only medical use, and a few prohibit all cannabis products. The therapeutic effects highlight the need for careful dosage consideration, especially regarding drug interactions and psychoactive properties. CBD influences the body’s endocannabinoid system indirectly by helping maintain balance in functions such as mood, immune response, pain perception, and sleep cycles. Unlike THC, it does not bind strongly to CB1 receptors in the brain, which are responsible for psychoactive effects. Under U.S. law, hemp-derived CBD (≤0.3% THC) is federally legal for therapeutic and commercial use. CBD provides therapeutic relief for anxiety, inflammation, chronic pain, and epilepsy, supported by FDA-approved formulations like Epidiolex. THC is extracted from marijuana, a cannabis variety cultivated for higher psychoactive potency.