Simply taking the medication without a conscious effort to eat nutritiously will likely yield suboptimal results. The effectiveness of Phentermine, a prescription appetite suppressant, is significantly enhanced when combined with a tailored lifestyle plan. For example, combining a diet rich in fruits, vegetables, and lean protein with 30 minutes of moderate-intensity cardio most days of the week can dramatically improve results. A comprehensive plan that incorporates both these aspects will yield better results than relying on the medication alone. Success relies heavily on individual factors, dietary changes, and regular physical activity. Phentermine is a sympathomimetic amine, which means it stimulates the nervous system to increase heart rate and blood pressure. The most successful dieters persevere despite obstacles or slower periods. The key is making sustainable changes to overcome plateaus, with adjustments as needed to your treatment plan under guidance from your doctor. Talk to your doctor about adjusting your treatment plan. It’s beneficial to develop a structured maintenance plan with your healthcare provider or nutritionist to help preserve the progress made during treatment. Many users report seeing noticeable changes within the first few weeks, especially when adhering to a calorie-controlled diet and regular physical activity. Weight loss results with Phentermine can vary depending on individual factors such as Weight Loss Drug Type, metabolism, diet, and exercise. “I’ve been struggling with my weight for as long as I can remember. I have been losing weight on my own since then, but at a much slower rate.” I lost 17lbs on my own from New Year’s until Feb 24, which is when I started phen. 24 months ( 10 ), after 12 weeks of taking the product, weight loss results achieved real. Downloads, resources, and weight loss product allowed her to control her appetite and lose kilograms. And effective when used according to healthline, after 12 weeks of taking the medication taken before breakfast 1. And pounds of weight loss when used alongside a reduced-calorie diet and exercising are! Most people notice weight loss within the first 2–4 weeks, especially if they follow a healthy meal plan and stay active. Some people develop tolerance to phentermine quickly, meaning the appetite-suppressing effect fades after a few weeks. Qsymia is effective in helping with weight loss for most people with obesity, but like any medication, it is not a guarantee. I’ve lost 2 pounds a week for a total of 10 pounds in 4 weeks. I started with just 15 mg 1x/day for the first week, then increased to 2-15 mg/day for 2 weeks, and then started 37.5 mg/day last week. “I’ve been on phen for exactly 1 month today. But hopeful for the next two weeks.” Although phentermine does not affect the secretion and reuptake of dopamine, negative viewpoints on central appetite suppressants originate from the addictive qualities of amphetamines. Thus, short-term phentermine therapy is considered relatively safe and effective. However, the mean weight reduction was 3.8 ± 4.0 kg (5.2% ± 5.0%) in our study, and 559 patients (82.0%) achieved more than 1.8 kg weight reduction. Phentermine is a schedule IV drug that requires a consultation with the doctor and a prescription. Even after the period that the drug has been prescribed for, the doctor will often recommend to gradually stop using the Phentermine to avoid the withdrawal symptoms. Patients who have been on a Phentermine program should not suddenly stop using the drug. Thus, in order to make the most of this drug, patients need make some effort too. In most cases, the drug is prescribed to users in periods of 12 weeks. Your starting weight and body composition can also influence your weight loss results. However, it’s essential to follow the dosage and treatment guidelines recommended by your healthcare provider to minimize the risk of side effects. While Phentermine 37.5 can be an effective weight loss aid, its effectiveness varies from person to person. Studies have consistently shown that Phentermine 37.5 is an effective weight loss aid. Subscribe to Cleveland Clinic Health Essentials The average weight loss when taking phentermine is 3% of your initial body weight after 3 months and 5–7% after 6 months. A healthcare professional may prescribe phentermine if you have obesity, defined by a body mass index (BMI) of 30 or greater. One such drug is phentermine — one of the most popular weight loss drugs in the world. Your doctor will help determine if phentermine is the right weight loss solution for you and provide guidance on how to use it effectively. The weight loss that occurs while on phentermine is often temporary if lifestyle changes are not maintained. While phentermine can kick-start weight loss, it’s not a long-term solution on its own. Additionally, Phentermine 37.5 is meant to be used as part of a comprehensive weight loss plan, which includes a healthy diet and regular exercise. Phentermine 37.5 is a prescription weight loss medication that belongs to a class of drugs called anorectics. Phentermine 37.5 is a powerful weight loss tool that can help individuals achieve significant weight loss when used in conjunction with a healthy diet and regular exercise. All subjects were eligible to enroll in the extension study if they completed the CONQUER study on treatment and complied with protocol requirements. Topiramate (Topamax; Janssen Pharmaceuticals), an anticonvulsant (200–400 mg/d) that is also approved for the prophylaxis of migraine headaches (100 mg/d), has shown weight-loss properties but is not currently approved as a therapy for obesity (10, 12–16). Thus, it is imperative that effective, long-term pharmacologic strategies are identified that may be used in conjunction with lifestyle changes to combat the obesity epidemic. However, adherence to lifestyle changes can be challenging for a wide variety of reasons, such as a lack of readiness for change on the part of the patient, physical restrictions that limit activity, and a shortage of therapeutic venues that include a multidisciplinary health care team essential to treatment effectiveness. Overall, 84.0% of subjects completed the study, with similar completion rates between treatment groups. As phentermine is thought to cause weight loss through suppression of hunger, it could be hypothesized that those individuals who eat excessively due to hunger (as opposed to emotional stress, boredom, etc.) might have a better weight loss response. While increased heart rate and blood pressure are often cited as potential adverse effects (13, 14), a number of studies have shown decreases in blood pressure (12, 15, 16), likely related to weight loss (although the decrease is generally less than that achieved by patients who achieve similar weight loss on placebo) (17). Studies on the effect of phentermine alone on weight reduction have shown a mean weight loss of approximately 5% over a short-term period (no studies of safety or efficacy beyond one year have been done) (9, 10, 11, 12). Phentermine is the most prescribed weight loss drug approved for short-term use (less than 12 weeks) by the Food and Drug Administration (FDA), and has been used steadily since its initial approval in 1959 (6, 7). Weight loss achieved by changes in diet and physical activity are the cornerstones in the treatment of obesity (2), but weight control methods often produce only short-term success (3, 4, 5). TEAEs were defined as AEs occurring between week 0 of CONQUER and ≤28 d after the last dose of double-blind study drug in SEQUEL. Multiple imputation was used as a sensitivity analysis to supplement the ITT-LOCF approach, and an analysis of subjects who completed the study while actively taking the study drug was also performed to understand the effect of treatment after 108 wk of exposure. LS means, corresponding SEs, 2-sided 95% CIs, and 2-sided P values for percentage weight loss within each treatment group were derived from the ANCOVA. It usually is taken as a single daily dose in the morning or three times a day 30 minutes before meals. Phentermine comes as tablets and extended-release capsules. Founded in 2001, Nexus Clinic is a top-notch aesthetic center, providing a comprehensive range of non-surgical aesthetic procedures and advanced laser treatments. Book your appointment with an authorised health expert right now. ” This comprehensive guide delves into the ins and outs of phentermine, its effects on weight loss, and the factors influencing individual results. The authors suggest that the percentage of body weight lost was higher with the study drug than with currently marketed weight-loss medications, but they noted the need for head-to-head trials before this finding can be validated. On July 17, 2012, the FDA approved a tablet combining phentermine plus extended-release topiramate (Qsymia, Vivus) for weight loss. When used under medical supervision and as directed, phentermine can be used short-term, but side effects may still occur in some patients. However, if you have a history of substance abuse and are considering taking Phentermine 37.5, it’s essential to talk to your doctor about your history. If you have a history of substance abuse, it’s generally not recommended to take Phentermine 37.5. Additionally, Phentermine 37.5 can be habit-forming, and long-term use can lead to dependence and withdrawal symptoms when stopped. Additionally, Phentermine 37.5 should not be used during pregnancy or breastfeeding, as it can harm the fetus or baby. On average, individuals can expect to lose between 1-2 pounds per week, which translates to around 4-8 pounds per month. Therefore, relying solely on online information for making decisions about your health, especially regarding medication like Phentermine, is strongly discouraged. It’s crucial to understand that individual experiences with Phentermine, and weight loss in general, vary significantly. The information provided in this article regarding Phentermine weight loss results within one month is for educational purposes only. Most patients report noticeable weight loss in this initial phase—often between 3 to 8 pounds, depending on caloric intake and activity levels. It's particularly effective for individuals with obesity or those struggling with significant weight-related health risks. Phentermine is a prescription-only appetite suppressant and weight loss pill approved for short-term use. Instead, it’s best to prioritize healthy, sustainable lifestyle habits that promote health beyond weight loss. Studies suggest Wegovy pills and injections provide similar weight-loss results. It works best when combined with a diabetes-friendly diet and regular exercise. Mounjaro is currently approved for the treatment of Type 2 diabetes in adults and children ages 10 and older. Lower-dose versions of Wegovy — Ozempic injections and Rybelsus tablets — are approved to treat Type 2 diabetes. In the STEP 2 trial comparing 1 mg and 2.4 mg of semaglutide for patients with type 2 diabetes, similar weight loss trends compared with those in our study were seen. Hence, this study may be a stepping stone to demonstrating the effectiveness of semaglutide for patients aiming to lose weight. Mild adverse effects did not affect dose escalation; moderate adverse effects prevented dose escalation; and severe adverse effects resulted in medication termination. If you take phentermine as prescribed, which is in the early morning, the drug should offer appetite suppression for the entire day and wear off towards bedtime. In this case, your prescriber may have you start with a lower Zepbound dose and slowly work your way up. But each medication’s dosage schedule looks a bit different. Zepbound is also being studied in certain people with heart failure, MASH, and chronic kidney disease. Wegovy has shown positive results for certain people with heart failure. It's crucial to understand that weight loss is a complex and personal journey․ Factors like genetics, lifestyle, and underlying health conditions can all influence the effectiveness of phentermine․ What works for one person may not work for another․ It's important to note that phentermine is not a magic bullet․ It is intended to be used as part of a comprehensive weight loss program that includes lifestyle changes like diet and exercise․ Moreover, it is not suitable for everyone․ Other conversations that discuss addiction to phentermine include people talking about how they continue to take phentermine despite no longer needing to lose weight or becoming dependent on it. The fact that this user is a healthy weight would indicate that this member has developed a dependence or possibly an addiction to phentermine, whereby she no longer needs to lose weight but is still taking phentermine after years, and now her health is suffering. Because phentermine was first tested in the 1950s, it was not subjected to the rigorous testing methods that the FDA now imposes, as shown by the extensive year-long trials into Contrave, the latest weight loss drug to be approved by the FDA. Qsymia may represent another safe and effective adjunctive treatment to be considered in the management of obese and overweight patients with comorbid medical conditions who would benefit from weight loss. Trials have demonstrated the clinical efficacy of phentermine/topiramate CR in all recommended doses. The antiseizure agents carbamazepine (Carbatrol, Shire) and phenytoin (Dilantin, Pfizer) may reduce plasma levels of topiramate by approximately 40% to 48%.7 Overall, phentermine/topiramate CR has a limited drug-interaction profile.6,7 More patients required antihypertensive and antihyperlipidemic medications in the placebo group than in the treatment groups, although no statistical analyses were completed for this observation. Some emerging research suggests potential benefits of careful extended use under medical supervision. This highlights why it is so important to use the 12-week period to build healthy lifestyle habits. This is to avoid the diminished effects and increased safety concerns. The Health Survey for England 2021 estimated that 25.9% of adults in England are obese and a further 37.9% are overweight but not obese. In the UK, the problem is magnified, particularly as our health services are nationalised. We must stress how important it is to use GLP-1s under proper medical supervision to ensure their safe and effective use. Continued monitoring is vital to ensure the medication’s safety and effectiveness, and to make adjustments based on your response and progress. It’s essential to consult your doctor before starting Phentermine. Open communication with your healthcare provider is key to managing potential risks effectively. ✅ Reduced hunger cravings✅ More energy and motivation✅ Slight changes in body measurementsIf you have taken an MAO (Monoamine Oxidase) inhibitor, which is a class of antidepressants, in the last 14 days, then phentermine is not recommended as there could be a dangerous drug interaction.For example, if you weigh 200 pounds, you may lose approximately 6-10 pounds in the first month.Many people start noticing weight loss results within the first few weeks of using phentermine, especially when it’s combined with healthy eating and regular activity.Phentermine 37.5 should be taken as directed by your doctor, usually once a day on an empty stomach before breakfast or 1 to 2 hours after breakfast.Weight loss, with a reduction in visceral body fat, has been observed with TPM treatment among patients with seizure disorders and migraines.23 Persistence of weight loss beyond the typical 6-month plateau was also noted.While increased heart rate and blood pressure are often cited as potential adverse effects (13, 14), a number of studies have shown decreases in blood pressure (12, 15, 16), likely related to weight loss (although the decrease is generally less than that achieved by patients who achieve similar weight loss on placebo) (17).Through regular consultations, monitoring, and ongoing support, Bodyline ensures that individuals receive the necessary guidance, education, and motivation throughout their weight loss journey. It is also ideal for patients that need some help losing weight but who react strongly to stimulants and do not need (or tolerate) a higher dose. Phentermine 15mg is popular among new users because some doctors prefer to start their patients on a lower dose and then only increase the daily dosage if necessary. VLCD usually is effective in promoting significant short-term weight loss.13,21 Given the effectiveness of VLCD, the ability to detect any differences between Phen and Phen-Fen may have been obscured. Another potential confounder (and weakness) is the concomitant use of VLCD with either Phen or Phen-Fen, which prohibited the direct measurement of the efficacy and impact of the study medications when used alone. AEs were minor, with 8% of the drug-treated patients and 3% of placebo-treated patients dropping out because of perceived stimulant AEs such as agitation or insomnia. But researchers haven't found that the drug causes liver injuries. In rare cases, people have had serious liver injury with orlistat. You need to follow a low-fat diet when taking this medicine. Orlistat can cause side effects such as passing gas and having loose stools. Dr. Primack, with a focus on health outcome effectiveness (we will discuss safety later), and beyond the weight reduction efficacy described by Dr. Lazarus, what is the objective evidence that phentermine improves health outcomes? The question we should be asking is whether phentermine safely helps a patient sustain weight loss for the long-term. Our registered dietitian nutritionists were, and continue to be, extremely effective at administering nutritional and behavioral interventions to help people with obesity reduce their body weight. With this background, Dr. Lazarus, what is your assessment specifically about the weight reduction efficacy of phentermine, and the clinical risks and benefits of prescribing phentermine beyond FDA-approved doses? Many patients in these chart reviews were treated with phentermine doses of 60 mg per day (and thus doses higher than approved by the FDA) 17,18, with reports that some clinicians prescribed phentermine doses as high as 112 mg per day . For those who do not have insurance coverage for Phentermine or those with high deductibles, some alternative options are available to help reduce out-of-pocket expenses. Individuals must consult their insurance providers to determine the specific coverage details for Phentermine. Some plans may offer partial or complete coverage for this treatment, while others may not offer any coverage at all. Providing universal guidance regarding phentermine treatment for obesity is challenging because of the lack of long-term, prospective, randomized, placebo-controlled, health outcomes data. In our study, 45.6% of patients lost ≥ 5% of their total body weight, which was slightly lower than previously reported data (range, 53.9% to 73.6%) by Choi et al.,12) and Park et al.,13) and who assessed the efficacy of phentermine under similar study conditions. Most often, healthcare professionals prescribe phentermine and topiramate after you’ve tried other lifestyle modifications for weight loss but haven’t seen significant results. The combination of phentermine and topiramate — sold under the brand name Qsymia — is a medication used for weight loss. What’s more, a recent analysis of studies found that people who took a medication that combined phentermine and topiramate lost 16 pounds (7.3 kg) on average compared with a placebo. Science-backed treatments without the clinic vibes. Your health glow-up, delivered. Always follow your healthcare provider's specific instructions. The real transformation happens over the following months as you continue treatment. Here's a detailed guide to what you can expect during your first four weeks. Provider-prescribed weight loss medications delivered to your door You may have more of a chance that Mounjaro is covered since type 2 diabetes medications tend to be covered more often than weight-loss drugs. "Similar to Mounjaro or other GLP-1 medications, you'll be closely monitored to see how well you do on a specific dosage, and that will tend to determine if you increase," says Sowa. Along with its needed effects, a medicine may cause some unwanted effects. This medicine may cause some people to become dizzy, lightheaded, or less alert than they are normally. Using these medicines together may cause serious unwanted effects. It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and does not cause any unwanted effects. Ask your healthcare professional how you should dispose of any medicine you do not use. In recent years, phentermine has gained more attention as obesity rates continue to rise. That’s why doctors carefully consider a person’s health history before prescribing phentermine. Otherwise, you can also speak to your primary care physician, obesity medicine provider, or endocrinologist about phentermine to see if it’s right for you. In the U.S., phentermine is a Schedule 4 drug, meaning it is a controlled substance and has the possibility of misuse. Obesity pharmacotherapy is new to using fixed drug combinations but promises significant potential.32,33 While the number of available molecular targets for obesity pharmacotherapy increase as well as the number of potential injectable adjuncts for obesity and its comorbidities,6,17,18,20,34 the number of oral agents available for potential fixed drug combinations is significantly more limited. Obesity pharmacotherapy has been very limited in its role for long term obesity management because of the past history of several failed agents as well as the fact that presently available agents are few, and generally utilized as monotherapy. Bariatric surgery remains a last resort though at present it has the best results for achieving sustained robust weight loss. How soon will I see weight loss with Phentermine? In our study, adverse effects were reported in approximately 50% of our cohort during follow-up. In our cohort, patients lost approximately 6.7 kg at 3 months and 12.3 kg at 6 months, equivalent to 5.9% of weight lost at 3 months and 10.9% of weight lost at 6 months. Our cohort experienced a wide range of weight loss responses to semaglutide at 3 and 6 months (eFigure 2 in the Supplement). Detailed information of the maximum dose reached by our cohort of patients is presented in eTable 2 in the Supplement. Benefits of Phentermine for Weight Loss Quitting smoking is one of the best things you can do for your health. Losing weight is not about getting it right – it's about getting started. There has never been a better time to kickstart your health. While anecdotal evidence can be compelling, understanding the scientific basis of phentermine is critical for making informed decisions about your health․ Therefore, relying solely on reviews and before and after stories can be misleading․ It's essential to consult with a healthcare professional to determine if phentermine is appropriate for you and to understand the potential risks and benefits based on your individual circumstances․ It has no side effects and can be taken for as long as necessary to achieve long-term weight loss. After 12 weeks of follow-up examinations, the compliance rate was measured by the percentage of patients who took medication during the observation period. Moreover, there are very few reports on the safety and efficacy of phentermine available on Korean populations. Therefore, it was suggested that research on separate medications was necessary for comparison with long-term research data. Compared to amphetamine, which has a similar chemical structure to phentermine, phentermine does not affect the secretion and resorption of dopamine, so it has been reported that phentermine has a very low chance of substance abuse or misuse.5-8) By now, the appetite-controlling effects should be helping you consistently eat in a calorie deficit, allowing for accelerated fat burning. “I decided to change my lifestyle because I was tired of being overweight. The most difficult part of losing weight for me has been social settings, especially with the holidays. However, I did follow a diet plan as per the doctor’s orders. Neurotransmitters — the chemicals norepinephrine, serotonin, and dopamine — are your body’s chemical messengers. Its chemical structure is similar to that of the stimulant drug amphetamine, and it’s available only with a prescription. Phentermine is a stimulant and is available only if you have a prescription. Phentermine hydrochloride tablet, orally disintegrating tablet. Transform your abstract objectives into concrete SMART goals to give your weight loss journey a boost. Phentermine is famous for the strong, immediate energy it provides patients, but sometimes this boost isn’t enough. Patients tend to lose slower as the pills’ effects weaken. Three- and six-month mean percentage body weight reduction (BWR%) efficacy of 30 mg phentermine, according to body weight loss in kilograms during the first month (1 mo-BWLkg) and development of tolerance to phentermine. Tolerance to 30 mg phentermine’s weight-reducing effect was defined as the absence of body weight loss for any given month with respect to the prior month. While numerous approaches exist, phentermine, a prescription medication, has emerged as a prominent player in the weight loss landscape. A study of abrupt phentermine cessation in patients in a weight management program. But newer studies show that long-term phentermine use (more than 3 months) is not only safe, but also helps people lose more weight. The question then becomes how can we use phentermine correctly to lose weight in the long term while avoiding negative side effects.This is analogous to combination treatment of diabetes, hypertension, and dyslipidemia, where use of drug treatments with complimentary mechanisms of action are commonly used to allow for lower doses of individual components, with overall enhanced safety, tolerability, and efficacy.It is designed for those who prefer a less invasive approach to weight management, focusing on natural ingredients that promote metabolic health and appetite control.Combining intermittent fasting with phentermine can enhance your weight loss efforts.A diet pill increasingly popular among San Francisco residents, the Phentermine weight loss craze continues to spread across the country.Achieving sustainable weight management involves various aspects, such as setting realistic goals, monitoring progress, and reassessing strategies when needed.On the positive side, phentermine can offer significant weight loss for those struggling with obesity and related health conditions. Prescription weight-loss drugs For speed, safety and satisfaction, nothing else even comes close. It is the only product available that combines the effects of multiple pills while still being completely natural and vegan-friendly. Finally, PhenQ enhances mood to combat the stress of dieting. You may report side effects to the FDA at FDA-1088. Discontinue Qsymia in patients who experience suicidal thoughts or behaviors. Advise patients who can become pregnant of the potential risk to a fetus and to use effective contraception during Qsymia therapy. For the subjects in the 2 trials the average baseline weight was 256 lbs and 227 lbs, and the average baseline waist circumference was 47 inches and 45 inches. †Qsymia was studied in 2 large trials supporting FDA approval that involved 3,754 patients 18 years and older whose BMI was 27kg/m2 or greater. My weight stalled after the first week so i am a bit down. I’ve now been taking it for 2.5 weeks and so far have lost 13lbs, so I’m currently 187lbs. I feel great when I’m feeding myself healthy foods. Do I need to follow a reduced-calorie diet while taking phentermine? The overall approach to the overweight and obese patient should be to identify individuals who will benefit most from therapy based on cardiometabolic or mechanical complications, establish therapeutic targets and goals for ameliorating these complications and selecting the treatment modality and intensity for weight loss to achieve these goals. You should notice weight loss within the first 8 to 12 weeks of starting Qsymia. And it’s one of the most effective oral weight-loss medications. Common Qsymia side effects, such as numbness, dizziness, and constipation, may improve as your body adjusts to the medication. In this study, we also found that almost 66% of subjects developed tolerance to phentermine (25% and 41% at months 2 and 3, respectively), defined as a BWR% lower than or equal to that achieved in the previous month. In our study, 30 mg phentermine significantly improved parameters such as waist circumference, FPG, triglycerides, cholesterol, HDL-cholesterol, and diastolic blood pressure. We found that daily oral administration of phentermine over a 6-month period led to weight reductions in a time-dependent manner, with a magnitude of 7.5 kg (8.3%) and 10 kg (11.2%), at months 3 and 6, respectively, although high interindividual variability was observed. A total of 803 adverse events (AEs) were reported for 166 patients receiving 30 mg phentermine during the 6-month follow-up period. The subclassification of patients according to 1 mo-BWLkg exhibited a clear relationship with the subsequent efficacy of phentermine in terms of mean BWR% (Figure 2A). Nephrolithiasis is also more common among patients taking topiramate and the incidence can be decreased with potassium citrate supplementation.62–64 The acidosis can usually be resolved by reducing the dose of topiramate and administration of sodium bicarbonate if needed. All of these patients were instructed to follow an ~1000 calorie/day diet but were not provided any further counseling regarding lifestyle modifications. So it’s easy to become frustrated with side effects and a lack of weight loss during the first few weeks of taking it. Changing up your exercise plan or paying close attention to your diet can help jump-start your weight loss. Qsymia (phentermine / topiramate ER) is one such example. Similarly, extreme caution should be used when considering prescribing lorcaserin to patients taking a selective serotonin reuptake inhibitor or serotonin-norepinephrine reuptake inhibitor due to the potential for serotonin syndrome.Phentermine can be helpful for short-term weight loss, but medications like Qsymia® and the GLP-1s are generally taken for longer and tend to produce more substantial results over time.This causes phentermine to increase energy levels, suppress appetite, and minimize cravings, making it an effective weight loss medication that helps you to lose weight quickly.In the study, phentermine-topiramate was shown to have the lowest likelihood of discontinuation due to side effects .Even if you have not seen huge reductions in your weight by week three, know that you are improving your health.Tell your healthcare provider right away if you have any new eye symptoms.If your doctor prescribes phentermine 15mg capsules twice daily, the second pill is typically taken around lunchtime.Well, it’s very probable that you have also succumb to a fad diet (who else still has nightmares about Atkins?). Losing weight was the first and biggest step into a new lifestyle that I desperately needed. I had tried almost every diet possible, and nothing seemed to work. At my parents’ advice (who were quite concerned about my weight), I made an appointment with the family doctor. Over the course of college, my weight became out of control. The 23-year-old New York City resident looked to her own mother for weight-loss inspiration. When Jasmine Addison’s daughter was born nearly 3 years ago, Jasmine’s weight climbed to its highest ever, almost 300 lbs. And it feels as if our nation is constantly searching for a magic bullet to keep weight off. They can assess your health and determine if Phentermine is right for you, and monitor you for any adverse reactions. Consistency, perseverance, and a commitment to making sustainable lifestyle changes are key to achieving and maintaining your weight loss goals. Remember, long-term weight management after one month of Phentermine is a journey, not a race. This process is personalized based on individual response to the medication and overall health. Weight management success hinges on integrating lifestyle changes that support continued weight loss and prevent weight regain. For some time interval ( usually days ) lose 21 kilograms during one course Stevie achieved these phentermine.3.7515 mg of phentermine & # x27 ; s weight loss can reach 10 % an in!By the end of week 2, you will probably notice that you’re making progress towards your weight-loss goal but are not plagued by the difficulties and forced deprivation of traditional calorie-counting diets.These side effects will often improve as your body adjusts to the medication.Qsymia is a combination prescription medication that’s FDA approved for weight loss.Phentermine 37.5 mg is a highly effective weight loss medication but must be used under medical supervision due to potential side effects and contraindications. In the first week of taking Phentermine, a big percentage of men and women can expect to lose anywhere from 1 to 3% of their starting body weight. Permanent lifestyle changes like healthy eating habits and exercise must continue to maintain weight loss once medication is stopped. Improvement or remission of weight-related health conditions for those who lose the most body fat. The majority of weight lost on Phentermine is regained within 18 months after stopping the medication if healthy habits are not adopted. Proactive HealthStarts Here. But together, under the brand name Qsymia, they deliver significant weight loss. Phentermine’s stimulant effects can lead to side effects such as dry mouth, insomnia, and tremors. She says that she loves the weight loss, but at what cost? “I feel like I’m going to come out with a heart problem because I wanted to lose weight from a pill.” These hurdles are necessary to ensure the safety of patients. Phentermine increases energy and reduces appetite by stimulating the central nervous system to release norepinephrine from the hypothalamus. On the low end, you can expect to lose 1lbs or more during that time. None of these patients exhibited cravings for phentermine or typical withdrawal symptoms that would be expected in a patient abruptly stopping therapy with an amphetamine related medication. The potential for abuse with phentermine is a major concern among providers which may preclude prescribing this agent for weight loss. Other contraindications for phentermine therapy include use with monoamine oxidase inhibitors, hyperthyroidism, glaucoma, agitation states, pregnancy, and use in patients with known history of drug abuse.55 Vivus (Mountain View, CA, USA) patented and licensed the fixed drug combination of phentermine and an extended release formulation of topiramate which will be discussed in more detail later in this review and was recently FDA approved for marketing under the trade name Qsymia (previously known as Qnexa).45–47 Five patients, 17%, experienced side effects that resolved after dose reduction or discontinuing phentermine. This study aims to assess the effectiveness and safety of phentermine use in pediatric patients with obesity. This cohort study assesses weight loss outcomes of semaglutide at doses used in randomized clinical trials for patients with overweight or obesity. In this cohort study of 175 patients with overweight or obesity, the total body weight loss percentages achieved were 5.9% at 3 months and 10.9% at 6 months. When combined with healthy eating and regular activity, a study shows it can help people lose an average of 5% of their starting weight over 12 weeks. Read on to learn more about phentermine including its usage effectiveness side effects and more. If you’re able to become pregnant, you’ll need to use reliable birth control while taking phentermine and topiramate, according to the manufacturer. In the placebo groups, 7 percent lost at least 10 percent of their body weight in both study 1 and study 2. In the placebo groups, 17 and 21 percent lost at least 5 percent of their body weight in study 1 and study 2, respectively. In study 2, 62 percent in the lower-dose group and 70 percent in the higher-dose group lost 5 percent or more of their body weight. Month 2 represents the time when healthy habits may start to become second nature. This is because your body adapts to the lower calorie intake. Taking the data from the studies above you can expect to lose roughly 3 – 6 lbs. The average woman lost 17lbs over 12 weeks while males weighed 21+/-3 pounds monthly (6-7 lbs). This time, the standard dosage was 37.5 mg per day and tested on 34 people – both men and woman alike! But if they don’t, talk to your healthcare provider. Phentermine is only approved for short-term use, but some studies show that long-term use is likely safe. Most people take 15 mg to 37.5 mg once daily in the morning. “You’re better off trying something else or trying to lose it the natural way.” “If it could cause real bad health problems in the long run, it’s not worth it,” she says. To avoid the possibility of dependence while still taking phentermine, you should build yourself up to face the end of your prescription by using phentermine as a tool to help you achieve a maintainable healthy lifestyle. If phentermine is taken without any effort to change the lifestyle in other ways, then it is to be expected that weight gain will occur once the phentermine prescription finishes. Phentermine is not a miracle pill, but rather a tool kick to start your weight loss journey and should be used only as a means to establish a routine of healthy eating habits and exercise to continue for life. Furthermore, it is important to remember that as phentermine is similar in structure to amphetamine, we cannot be sure that long-term usage doesn’t harm the body in some of the ways that amphetamine does when taken long-term. Three phase III randomized, placebo-controlled trials evaluated the safety and efficacy of phentermine-topiramate combination in the treatment of obesity.It’s an injectable medication that mimics GLP-1 but blocks GIP.Taking drastic steps to lose more than that is typically a bad idea because it is not sustainable and makes it more likely you'll regain any lost weight.Doctors usually prescribe it for a few weeks at a time, and patients return for check-ups to evaluate their progress.Two reports show no increased risk of birth defects or any other negative outcomes for the baby if a woman is exposed to the drug during pregnancy.These appointments also provide opportunities to discuss dietary progress, exercise adherence, and any concerning symptoms. By making sustainable lifestyle changes, you can maintain your weight loss progress and reduce the risk of regaining weight. It’s possible to regain weight after stopping Phentermine, especially if you return to old habits and do not make sustainable lifestyle changes. Additionally, long-term use of Phentermine can lead to dependence and withdrawal symptoms when the medication is stopped. The FDA label even states that "dosage should be individualized to obtain an adequate response with the lowest effective dose." Phentermine is not currently available for purchase over-the-counter (OTC) in the US. While these side effects aren’t life-threatening, they can be uncomfortable. The focus of our articles is to share our opinion on the potential efficacy and safety of health trends and products. He's also an entrepreneur who runs a health and wellness startup. Some people may experience more significant weight loss, especially if they follow a strict diet and exercise routine. Phentermine is usually prescribed alongside a calorie-restricted diet and exercise plan for optimal weight loss results. As an appetite suppressant, it can significantly assist in achieving weight loss goals when combined with a healthy diet and exercise. The adverse event profile shown by 30 mg phentermine in this work was similar to those reported in other studies with high phentermine doses 19,20. Eligible subjects were randomized to receive either continuous phentermine (30mg daily) or intermittent phentermine therapy (30mg daily for 4 weeks alternate with 2 weeks of treatment-free periods) for a total of 24 weeks, in addition to lifestyle modification (comprising of calorie restriction of 1200 kcal per day and at least 150 minutes per week of moderate intensity exercise). Phentermine is used for a limited period of time to speed weight loss in overweight people who are exercising and eating a low-calorie diet. As a short-term appetite suppressant, it can help people jumpstart weight loss when combined with healthy eating and regular activity. Lynn Grieger is a registered dietitian-nutritionist, certified diabetes care and education specialist, certified personal trainer, and certified health and wellness coach. Try adopting these diet and lifestyle habits that can support a goal to lose 1 lb. Check out our curated list of the best weight loss apps to help you track food intake, set goals, and achieve your fitness objectives. Small changes that increase your activity and reduce your caloric intake can lead to more sustainable weight loss. Check out our curated list of the best weight loss apps to help you track food intake, set goals, and achieve your fitness objectives. KellyLost 70 Pounds These numbers highlight the importance of commitment and combining medication with lifestyle changes. Regular check-ins help monitor for side effects like insomnia, palpitations, constipation, or increased blood pressure. We encourage customers to focus on a balanced diet rich in fruits, vegetables, and lean proteins, while cutting back on sugar and processed foods. On average, Duromine users lose 1-2 kg weekly in the first month. Our content is created with the support of qualified professionals and based on well-established research from trusted medical and scientific organizations. At Noom, we’re committed to providing health information that’s grounded in reliable science and expert review. Weight loss results from Zepbound versus Wegovy in a month can depend on individual response, diet, and physical activity. The best way to save on Zepbound or Wegovy is to use your health insurance. In some cases, they may be able to raise it or switch you to a different medication. Since Zepbound and Wegovy work in similar ways, this combination could increase the risk of side effects. However, since then research has shown that long-term use of the drug for up to a year or more is an effective way to lose weight and sustain weight loss. Studies have shown that obese or overweight people who suffer from BED or bulimia nervosa, and have been treated with phentermine, have lost not just weight, but also seen a reduction in binge eating episodes. The control of weight related diseases is shown to be a direct result of weight loss, rather than the effect of the phentermine. Adipex-P can help people lose up to an average of 5% total body weight and studies have shown that over a period of 12 weeks, people can lose as much as 10% of their body weight. Through appropriate use of this drug combined with a healthy exercise and diet regimen, weight loss can occur. However, because of its stimulating effects on the central nervous system, phentermine weight-loss pills can be addictive, which is why it is not available over the counter. How does phentermine work, and how does it achieve the weight loss it promises? An appetite suppressant may help make your weight-loss journey easier, and one such medication is phentermine weight-loss pills. Qsymia may help adults and children 12 years and older with obesity, or some adults with overweight who also have weight-related medical problems, to help them lose excess body weight and keep the weight off. We recommend that patients follow their doctor’s guidance in regard to prescription medication. We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. We strive to make weight loss as simple and as easy as possible. However, the aim of the study was to identify patterns of appetite expression and eating behaviors that could predict greater response to treatment. This helps people stay active and burn more calories throughout the day. It is similar to amphetamines, which are drugs that increase energy and alertness. Phentermine is a stimulant that affects the central nervous system. Rare side effects include suicidal thoughts and serious eye problems that may lead to vision loss. People who are pregnant are warned against taking this drug, as it can cause congenital disabilities, such as cleft lip or palate. According to Cleveland Clinic, you should aim to lose 1 to 2 pounds per week. Forty percent of the participants in study 1 and 31 percent of participants in study 2 dropped out before the studies’ completion, however. That said, existing research studies can give you an idea of what to expect from this medication. A study of tirzepatide (LY ) in participants with overweight or obesity and chronic kidney disease with or without type 2 diabetes (TREASURE-CKD). A study of tirzepatide (LY ) in participants with obesity or overweight with weight related comorbidities (SURMOUNT-5). Your healthcare team can help determine which option may be better based on your medical history and individual response. While the average results may range between 5-10% of body weight lost in a few months, some users experience even more substantial results. It’s essential to undergo a thorough examination and have a candid conversation about your medical history, current health conditions, and lifestyle choices. Keeping an open line of communication with your healthcare provider is crucial for managing these effects. Many people face challenges post-treatment, such as cravings or the temptation to revert to old habits. Genetics also play a pivotal role in how our bodies process food and maintain or lose weight. A randomized, double-blind, placebo-controlled, 52-week extension of the CONQUER trial was conducted to determine the long-term efficacy and safety of phentermine/topiramate CR (see Table 2, page 449). The hard gelatin capsule contains immediate-release phentermine and extended-release topiramate beads.6,7 Because earlier studies used the designation phen/tpm cr (controlled release), CR is used for the generic drug name in this article. Phentermine gives you momentum, but sustainable success comes from the habits and healthier patterns you build to last far beyond stopping any weight loss drug. In summary, when combined with lifestyle changes, phentermine may lead to pounds of weight loss or 3-9% total loss over 3-6 months. You’ll meet again with your doctor and counselor, who may adjust your phentermine dose or switch you to the extended-release formula to sustain effects. Treated patients lost significantly more weight than those receiving placebo. Secondary outcomes included absolute weight loss; the proportion of patients with a weight loss of more than 10%; changes in waist circumference; and changes in BMI, BP, lipids, fasting blood glucose levels, glycosylated hemoglobin (HbA1c) and fasting insulin. Primary outcomes were percentage of change in body weight and the proportion of patients achieving at least a 5% reduction in weight. Low-dose treatment demonstrated decreases in all secondary measurements compared with placebo, although not all reductions were significant. You can calculate your BMI using online calculators, though it’s important to bear in mind that BMI is a controversial tool for measuring weight health.Side effects from phentermine were minimal, just some constipation and reduced appetite.Talk to your doctor about any concerns and before making changes to when or how you take your phentermine.Bariatric interventions on the NHS are only performed on individuals with a BMI of over 40, or over 35 with weight health related problems.The authors suggest that the percentage of body weight lost was higher with the study drug than with currently marketed weight-loss medications, but they noted the need for head-to-head trials before this finding can be validated.Then your provider talks with you about the pros and cons of prescription weight-loss drugs.In a multicenter clinical experience assessing the outcome of FDA-approved AOMs (eg, phentermine-topiramate, liraglutide, orlistat, and naltrexone-bupropion), weight loss of 5.0% was achieved at 3 months compared with 5.9% in the present study, and weight loss of 6.8% was achieved at 6 months compared with 10.9% in the present study.But it may also cause some brain-related side effects, especially at higher doses. But I only lost half of the weight. After the birth of my second child, I gained weight again. But now that I’ve lost all that weight, I can actually keep up with my children.It’s absolutely possible to get to your goal weight. Seeing the diet doctor was a birthday gift from my mother. For even more health benefits, aim for at least 60 minutes of physical activity most days of the week. Even small amounts of physical activity are helpful, and accumulated activity throughout the day adds up to provide health benefit. This can be a great way to get aerobic activity, improve your heart health and increase your endurance while burning calories. Phentermine 37.5 is generally considered safe to use when taken as directed and under the guidance of a healthcare professional. It’s essential to note that these are general estimates, and actual weight loss results may vary significantly. Phentermine 37.5 is a controlled substance and is typically prescribed for short periods of time (usually 3-6 months) for individuals who are obese or have a body mass index (BMI) of 30 or higher. Still, this side effect is extremely rare and the risk is much lower with phentermine than with fen-phen. But there have been rare cases of PPH reported with phentermine alone. There have been no reported cases of heart valve disease related to phentermine alone. Unfortunately, the combination of these two medications can cause dangerous side effects. It is important to follow your healthcare provider's instructions when taking phentermine to minimize the risk of side effects. If you experience any side effects while taking phentermine, it is important to tell your healthcare provider. Phentermine is generally not recommended for people who have certain medical conditions or are taking certain medications, as it may not be safe for them. Phentermine is a prescription medication that is typically only recommended for people who are obese or have a weight-related medical condition, such as type 2 diabetes or high blood pressure. Adopting a healthy diet rich in fruits, vegetables, and whole grains, engaging in regular physical activity, and managing stress effectively can all contribute to long-term weight management. However, phentermine can also lead to side effects, including dry mouth, insomnia, elevated blood pressure, and increased heart rate. Some individuals encounter side effects, experience plateaus in weight loss, or even face setbacks due to a lack of long-term lifestyle changes. Association of pharmacological treatments for obesity with weight loss and adverse events. Monitor height velocity in pediatric patients treated with Qsymia. Since Qsymia has the potential to impair cognitive function, patients should be cautioned about operating hazardous machinery, including automobiles. For clinically significant or persistent symptoms consider dose reduction or withdrawal of Qsymia. The primary treatment to reverse symptoms is immediate discontinuation of Qsymia. Qsymia is not recommended in patients with a history of suicidal attempts or active suicidal ideation. Doctors used it to help patients who experience certain health issues caused by obesity to lose weight and improve the symptoms they are experiencing. While phentermine can be a helpful tool for some individuals, it's essential to remember that weight loss is not a one-size-fits-all solution․ A holistic approach that addresses the underlying causes of weight gain and promotes sustainable lifestyle changes is crucial for long-term success․ Numerous clinical trials have been conducted to evaluate the effectiveness and safety of phentermine for weight loss․ These studies have shown that phentermine can lead to modest weight loss in the short term, typically within the first few months of use․ In some cases, these side effects can be severe, leading to discontinuation of the medication․ Some individuals may also experience withdrawal symptoms when they stop taking phentermine․ Many individuals report significant weight loss with phentermine․ They describe feeling less hungry, having more energy, and seeing the numbers on the scale drop․ This can be a powerful motivator and offer a sense of hope for those struggling with weight loss․