‘The large landmark studies which initially proved the effectiveness of these drugs for weight loss all incorporated lifestyle advice and support, not just a leaflet as many online prescribers give.' The key to successful use of these drugs, says Dr Williams, ‘is ongoing support, motivation and expertise to ensure that people do all of the right lifestyle and psychological interventions alongside the medication.’ 'Any mechanism of weight loss will impact on “fat-free mass”, eg, other tissues, not just fat, including bone and muscle,’ agrees Dr Jennifer James, a physiotherapist, lecturer and researcher specialising in obesity management. Boy George opened up about his weight-loss journey in his memoir. "I was one of those people that felt so sick and couldn't play with my son. I was so skinny and he's throwing a ball at me and I couldn't," she continued. She also tried Wegovy but "could not handle" the side effects. Amanda Bynes kicked off her weight-loss journey by turning to Ozempic. As you move through different phases of treatment, expect your rate of weight loss to evolve according to dosage and duration. These findings are consistent across age groups, health conditions, and genders, supporting Mounjaro’s role in the treatment of obesity. Duration is equally important; most patients see the greatest changes between 12 and 72 weeks. The only difference is that you take Ozempic at a lower dose. Most side effects get better on their own or resolve with lifestyle changes. They also ramp down overall inflammation in your body. Research indicates that regaining weight after stopping Mounjaro can occur, especially if lifestyle changes aren't sustained. Always consult a healthcare provider before adjusting dosages for optimal results. However, individual responses vary based on factors like starting weight and lifestyle. It's important to review the comprehensive information provided on the product page to understand its active ingredients, potential side effects, and dosing options. These medications work by influencing the body’s hormonal response to food intake, slowing digestion, and helping users feel full longer. A dual-action treatment that targets weight loss and blood sugar control. At Vivari Aesthetics, we deliver expert guidance on weight loss injections in Johannesburg and other major cities, ensuring a safe, medically supervised journey towards a healthier lifestyle Until now, people could only access the drug through a special weight loss service. Alongside maintaining a balanced diet, integrating consistent movement can improve overall health outcomes, assist with weight management, and reduce common side effects. This dietary approach not only aids in achieving significant weight loss results but also aligns with healthy habits that sustain long-term success in your weight management journey. Gradually increasing the dose, as recommended by your healthcare provider, can enhance the effects of Mounjaro. Adhering to your treatment plan and maintaining a regular schedule for injections fosters a more sustainable rate of weight loss. How to inject MOUNJARO will be explained to you by a healthcare professional. The dose of your sulfonylurea or insulin may need to be reduced. Do not use MOUNJARO if you are pregnant as the effects of this medicine during pregnancy have not been studied. Ozempic side effects follow a similar pattern but may feel milder for certain users. Ozempic and Mounjaro share many side effects because both affect gut hormones. This gap matters most for patients with higher starting A1C levels. However, both medications have distinct mechanisms and characteristics.To take Ozempic for weight loss, you will likely have to pay for it out-of-pocket unless your doctor lists your diagnosis as diabetes.GLP-1 medicines should not be taken by people who are breastfeeding.What should I do if I experience side effects from these medications?Research indicates that consistent healthy habits are crucial for weight maintenance.Phase 2 trials showed an unprecedented 24% average weight loss at 48 weeks, with 100% achieving 5% reduction.“While being an effective weight loss aid, it is not a miracle drug. Serious but rare side effects I am excited to start the weight loss journey as have tried so many other diets . I don't want to lose weight any faster as I'm exercising as well to make sure I don't end up flabby I found that helped because when I was hungry I was able to eat the healthier food I’d prepared, whereas this week I’m just reaching for the regular family meals. I’m 5.5 stone overweight but want to lose 4 stone. That is a pretty incredible weight loss Tiger you must be delighted! Figure 1. Flowchart of the Study. With us, there are no awkward conversations with GPs to worry about, just a simple online questionnaire to assess your suitability for the medication. We’re committed to making healthcare easier, which is why we offer a seamless ordering process that includes fast and discreet delivery. You should rotate your injection sites around these areas each week or divide each section into four and move around these weekly. If irritation or inflammation around your injection sites is making you dread your next Mounjaro dose, it could be because you’re not rotating the site regularly. Don’t worry if your results are different from those reported in clinical trials. Recognising that these factors will make your journey unique and different from others', it will be easier to focus on your journey and stick to your new, healthy habits. So, even if you haven’t noticed significant changes to your weight, look out for signs like a reduced appetite and fewer cravings. However, this can vary from person to person, and at this time, you will have only been on the lowest 2.5 mg dose of Mounjaro. After all, you’ll want to know whether the medication actually does what it’s supposed to. Clinical trials have shown that on average, patients lost up to 22.5% of their original weight on the highest dose of Mounjaro® (15mg) after 72 weeks. While some of them are only approved as treatments for type 2 diabetes, all of them can make people lose weight. How do these medications affect metabolic health beyond weight loss? Most people lose 2-4% of their body weight on this dose during the first month. Research shows that patients who develop healthy habits alongside medication tend to maintain more weight loss after stopping. Eli Lilly, the maker of Mounjaro, and Novo Nordisk, the maker of both Ozempic and Wegovy, told ABC News that people who experience side effects using the medications should contact their health care providers. As the popularity of injectable weight-loss drugs like Ozempic, Mounjaro and Wegovy continues to rise, some users of the drugs are speaking out about the reality of the medications' reported side effects. Clinical trials have shown that tirzepatide can lead to significant weight loss with patients potentially losing up to 20% of their body weight. Clinical studies highlight Mounjaro’s effectiveness in weight reduction, showing participants losing up to 20% of their body weight over 72 weeks, particularly at higher doses. It found that first generation GLP-1 receptor agonists such as liraglutide and exenatide may have anti-cancer benefits beyond weight loss. Experts already know that losing weight reduces the risk of cancer, but now they think weight-loss jabs may have a role beyond simply helping people shed pounds. At the moment, GLP-1 agonist medicines designed to aid weight loss are only available as injections. Unlike semaglutide or tirzepatide, liraglutide is injected every day. Embarking on a weight loss journey with Mounjaro can be transformational, and support is crucial for your success. Patients recommended to consider Mounjaro typically have a higher starting weight and are open to implementing lifestyle changes alongside the treatment. Its dual-action formula targets blood sugar regulation while promoting weight loss, making it ideal for those with metabolic concerns. Clinical trials indicate that its active ingredient effectively promotes weight loss while maintaining stable blood sugar levels. Clinical trials indicate improvements in glucose control, making it an effective treatment for type 2 diabetes. Define a long-term weight management plan Formulate a personal comprehensive plan for long-term weight control Improvements in measurable health metrics e.g. reduced blood pressure, improved cholesterol or blood glucose control As your dosage increases you should see changes in your weight and your lifestyle. Deals of the Day In STEP 6 (east Asian population with or without diabetes), mean weight loss from baseline to week 68 was 13.2% with semaglutide 2.4 mg, 9.6% with semaglutide 1.7 mg and 2.1% with placebo. Among participants with type 2 diabetes in the STEP 2 trial, the reduction in body weight with semaglutide 2.4 mg was 9.6% (vs. 7.0% for semaglutide 1.0 mg and 3.4% for placebo) from baseline to week 68 (Table 2). STEP 239 enrolled individuals with type 2 diabetes glycated haemoglobin (HbA1c) 7.0%‐10.0%, and randomized them to once‐weekly subcutaneous semaglutide 2.4 mg, semaglutide 1.0 mg (the approved dose in type 2 diabetes) or placebo for 68 weeks. Older pharmacological options for chronic weight management, such as orlistat, phentermine‐topiramate and naltrexone‐bupropion, typically show moderate efficacy (~3%‐9% mean weight loss over that achieved with lifestyle intervention alone).18, 27, 28, 29, 30, 31 Liraglutide 3.0 mg once daily administered subcutaneously was the first GLP‐1 receptor agonist (GLP‐1RA) to be approved for weight management, after demonstrating weight losses of 4%‐6% over those achieved with lifestyle intervention alone in clinical trials of 20‐56 weeks' duration. Designed for diabetes treatment but used off-label for weight loss at doses lower than Wegovy. You’ll start at 2.5 mg, even if you’ve taken other medications before, and keep moving upwards until you reach your chosen maintenance level or the maximum strength of 15 mg per week. Mounjaro doses are titrated in increments of 2.5 mg, with a minimum of 4 weeks between increases. For example, at the highest tolerated dose of 10 or 15 mg per week, study participants lost, on average, 18.4% more weight than the placebo group. By increasing insulin sensitivity and reducing hunger pangs, Mounjaro can lead to gradual and sustainable weight loss when combined with a healthy diet and an active lifestyle. Some weight regain is common, and it’s not a failure. If you ever need to stop your GLP-1 medication, be gentle with yourself. When you stop taking them, these effects gradually reverse. That said, many lose 2 to 5 pounds in their first 30 days. The first month is usually about letting your body adjust. The SURMOUNT-5 trial reported an average 20.2% weight loss with Mounjaro 15 mg compared with 13.7% with Wegovy 2.4 mg after 72 weeks.1 GLP-1 medications don't change the fundamentals of healthy eating, Kessler writes, and it's important to be mindful about your food choices on the drugs. Weight loss drugs are a prescription treatment designed to support weight loss alongside diet and exercise. Remember, this is your weight loss journey and how your body responds to treatment, how long it takes to lose weight, and the amount you lose will be unique to you. After three to four weeks of Mounjaro treatment, many people notice their side effects easing. Perhaps a bigger conversation than side effects for individuals is around the impact on people who rely on these treatments, now they've exploded in popularity as a weight loss quick-fix. In 2022, the US Food and Drink Administration (FDA) fast-tracked approval of the drug to treat obesity after a study showed it helped people lose more than 20% of their bodyweight. As Sky News research revealed thousands of severely obese patients are facing severely delayed treatment, here we look at the wave of weight loss drugs and how they work. Research has suggested weight loss jabs, officially GLP-1 receptor agonists, could almost halve the risk of obesity-related cancers. The drugs also only work for as long as you carry on taking them, and people have reported gaining back all the weight they lost after stopping the drug - either out of choice or because of a supply shortage. Facial ageing is a side effect of sudden weight loss as people find the skin on their face sagging where once it was plump. 'For people using GLP-1 medications, the goal is muscle preservation, metabolic protection and sustainability, not extreme calorie burn,' says Dr Ajaz. I did take Ozempic a couple of year ago and managed to lose about 2 stone on it but found I piled it all back on again when I stopped taking it. I’ve just had my first jab and waiting for the effects to kick in!! There are no quick fixes and although I’m on 7.5mg it’s still hard work… I log everything that passes my lips and monitor my nutrient intake closely. I lost 1 stone on 2.5 - my largest loss on any dose. It is not recommended that you stop taking Mounjaro for weight loss without consulting with your GP. At certain intervals, you’ll be asked to update our clinicians on your weight to make sure the treatment is still suitable. If you’d like to request Mounjaro® for weight loss, please complete our weight loss consultation. They can be worse when starting treatment or going up a dose. This, however, requires daily rather than weekly injections. Another option is Saxenda, which works in a similar way to the drugs above – using the active ingredient liraglutide. Pill versions are likely to make it to the UK soon (though approval is still pending here) and should make it both much more affordable and convenient to take these drugs. Mounjaro contains tirzepatide and works slightly differently. Particularly when it comes to using new medication. It’s also worth talking to your doctor if you’re not seeing the results you’d hoped for on your current dose. This leftover liquid isn’t enough for another dose. The extra amount that’s left is used as a buffer, to ensure there’s enough liquid available for all four injections (you lose a tiny bit of liquid when you prepare the pens for use). This dual action not only results in significant weight loss, but also helps regulate blood pressure and other metabolic parameters. Tirzepatide works through dual agonism of the GLP-1 and GIP receptors, offering a powerful mechanism for weight loss and metabolic improvement. As part of a comprehensive treatment plan that includes healthy habits, Mounjaro can enhance overall well-being by also addressing blood sugar and blood pressure levels. Kessler says drugmakers should do more to inform patients about the risks of developing eating disorders, and gastroparesis – a chronic condition where gastric emptying slows down significantly. "So keeping the GI tract healthy is essential." "People think constipation is just constipation, but that constipation can turn into intestinal obstruction that can cause perforation and people can die," says Kessler. The Real Housewives of Atlanta alum revealed her failed attempt to lose weight with the injectable medication. "I cant believe this is me now," Rosie wrote on her Instagram, "#mounjaro #weightloss #bodydismorphia." Years before Dancing With the Stars, the Secret Lives of Mormon Wives star revealed she was taking semaglutide injections—which are sold under the brand names Ozempic and Wegovy—to lose weight. These Mounjaro before and after success stories truly highlight the impressive weight loss transformations that are possible when taking the medication. When you choose Mounjaro as your preferred weight loss treatment, there are several things you must consider. As a baseline, with diet and exercise alone, a common guideline for safe and sustainable weight loss is 1-2 pounds per week. While originally created for type 2 diabetes, they have been highly effective for weight loss. Vivari Aesthetics offers personalized consultations with specialists who assess your eligibility for Mounjaro in South Africa based on your health status and weight loss goals. While Mounjaro suppresses hunger and reduces food cravings, our coaches help you optimise these effects by guiding you toward a balanced lifestyle. Make sure to rotate the injection site each week to prevent irritation. It comes in a pre-filled injection pen that you take once a week. If you fit these criteria, then you may be eligible for treatment. He says if you're trying to lose weight, with or without drugs, protein is key, because it increases feelings of fullness. They can be a powerful part of a plan to achieve and maintain a healthy weight, he says, but the drugmakers and the FDA should do more to educate consumers about the side effects. While BMI or body mass index has long been used to measure obesity, Kessler is among a growing number of scientists who say it's not a helpful indicator of health. Here are eight takeaways from our conversation with Kessler about using the GLP-1 drugs, and the changing landscape of weight loss. It is always best to allow your body time to firm up following weight loss injections. Approved Indications in the UK Tirzepatide (Mounjaro®) might not be suitable for everyone and not everyone who meets the eligibility criteria will want to use it to support their weight loss. What other options do I have for weight loss support via the NHS? There will be a phased approach to service rollout within primary care and, initially, tirzepatide (Mounjaro®) will only be available on the NHS to those with the highest clinical need. Whoopi Goldberg used the medication to 'jumpstart' her metabolism. Tracy Morgan informed Hoda Kotb and Jenna Bush Hager on the Today show that he used the Type II diabetes drug to "cut his appetite in half." As Spelling is now happy with her weight, she reportedly felt she "didn't want to get any thinner." "I did whatever anyone told me to do that was safe and it just wasn't working. The weight wouldn't come off." "I'm too gaunt and I can't put any weight on. I want to, because I feel I'm too skinny," she told Daily Mail. Holistic skincare approaches to support overall skin health and well-being. Effective solutions for a variety of skin concerns, promoting clear and healthy skin. Revitalize your skin with advanced treatments designed to restore a youthful glow. Advanced treatments to lift and lighten the skin, enhancing firmness and brightness. Comprehensive care for skin lesions and bumps, promoting clear and healthy skin. So, what are your long-term weight loss prospects on Mounjaro? However, weight loss isn’t the only notable change after 6 months on Mounjaro. Continuing these changes is key to your continued weight loss success. It’s important to remember that Mounjaro is intended as a long-term weight loss solution, rather than a miracle cure. That means it can now be prescribed to eligible patients in the UK.C Additional health benefits seen in clinical studies.Additionally, personal lifestyle choices, such as diet and physical activity levels, are crucial in determining the overall effectiveness of Mounjaro in achieving weight loss goals.Initially developed for type 2 diabetes management, its ability to support weight loss has garnered widespread attention.Please see who can get this treatment in the section above.The clinical trials of SURPASS reported on the gastrointestinal system, and nausea, diarrhea and vomiting were the most common AEs .As well as this, by mimicking the GLP-1 hormone, tirzepatide slows digestion, reduces hunger, and combats cravings. For those searching for Ozempic Johannesburg, Vivari Aesthetics offers easy access to this groundbreaking medication. At Vivari Aesthetics, every consultation includes a comprehensive medical assessment to determine your suitability and create a personalised treatment plan. ‘Once stopped, weight regain is common unless there’s been a concurrent and sustainable lifestyle change,’ says Dr Wylie. GLP-1s are medicines licensed to treat specific medical disorders and should only be used if you are overweight or diabetic, and not if you want to lose weight for aesthetic or cosmetic purposes. In the UK, there are several licensed GLP-1 medicines including semaglutide (sold under the brand names Wegovy, Ozempic and Rybelsus), tirzepatide (Mounjaro) and liraglutide (sold under various brand names). You may see them referred to in the media as “weight loss injections” or “skinny jabs” but not all of these medicines are authorised for weight loss. They both help control appetite and support steady weight loss. This is to give your body the chance to adjust to the medication and reduce the potential impact of side effects. Indeed, they lost 1.5 stone (21 lbs / 9.5 kg) in just the first five weeks of using the medication. This user had already begun their weight loss journey before taking Mounjaro, but their progress was vastly accelerated once treatment had started. Without further discussion, let’s review ten real Mounjaro weight loss before and after stories and the people behind them. If you’ve been considering adding Mounjaro to your own weight loss regimen, you’ll likely want to know more about how the treatment could benefit you. By focusing on proven data, personalizing your lifestyle, and utilizing expert resources like Healthon, you can confidently approach your weight loss journey with Mounjaro. Most patients notice more rapid changes after moving from 5mg to higher doses, especially by month two or three. The weekly rate may vary, but most see noticeable progress within the first four to eight weeks. Additionally, personal lifestyle choices, such as diet and physical activity levels, are crucial in determining the overall effectiveness of Mounjaro in achieving weight loss goals. Gender differences also play a role; hormonal variations can influence how body composition shifts in response to treatment. Between your particular metabolism, medical history, stress levels, and dozens of other factors, your body will respond in its own way and time. The risk of side effects, insurance coverage and drug availability are things to consider as well. Dr. Nick Stucky, an infectious disease physician at Providence Portland Medical Center and the study’s senior author, said the results alone should not cause patients to stop taking a drug that is working for them. “Individuals that have the genetics to become diabetics probably have the genetics to gain weight and hold onto it better,” he said. The researchers didn’t compare the risk of milder problems like nausea and vomiting because people wouldn’t necessarily report them to their doctors, Rodriguez said. Be more active and making healthier food choices Helps the body make more insulin and lowers blood sugar levels Our expert clinical team and pharmacists are here to support you every step of the way. Rather, the results show the effectiveness of semaglutide 2.4 mg in those with overweight or obesity, probably through its ability to control appetite, energy intake and food cravings. STEP 3 assessed the impact of semaglutide 2.4 mg in combination with intensive behavioural therapy and an initial low‐calorie meal‐replacement diet, reporting mean weight loss of 16.0% (vs. 5.7% in the placebo group).40 However, in the other STEP trials, a less intensive lifestyle intervention programme was used, and similar levels of weight loss were achieved, suggesting that an intensive approach may not contribute significant additional weight loss. However, the benefit of the higher dose is seen in the context of greater weight loss.39 Semaglutide 2.4 mg for 2 years resulted in substantial and sustained changes in body weight versus placebo in STEP 5 (−15.2% vs. −2.6%),42 demonstrating encouraging long‐term maintenance of weight loss. STEP 2 was the only trial to include a once‐weekly semaglutide 1.0 mg treatment arm in addition to the placebo arm. The pen device allows dose adjustments in 0.6 mg increments, offering more granular control than weekly medications. Approximately 86% of people achieve clinically meaningful weight loss of 5% or more on Wegovy. The STEP 1 trial showed participants achieved an average 14.9% weight loss over 68 weeks when combined with lifestyle interventions5. Semaglutide 2.4 mg, branded as Wegovy, was the first weekly GLP-1 medication specifically approved for weight loss in the UK. Most users on Mounjaro experienced a reduction of 2–4% in the first month, with average weight loss reaching 15–25% after prolonged use. Extensive clinical trials, especially the SURMOUNT series, highlight Mounjaro’s impact on weight management. Clinical trials consistently show that the dosage of Mounjaro plays a crucial role in determining the rate and magnitude of weight loss. Clinical trials indicate that individuals using Mounjaro exhibit more significant reductions in body weight compared to those taking Ozempic. By targeting both GLP-1 and GIP receptors, it promotes greater weight loss results and improved blood sugar control. The values in italics indicate the available maintenance doses for each of the two treatments. If you are considering stopping Mounjaro, speak with your clinician to plan a gradual taper and maintain your weight loss. Mounjaro is supplied as an injectable pen with four pre-filled doses, so you don’t need to draw up the medication beforehand. How many Mounjaro pens you’ll need will depend on how long it takes to reach your weight loss targets. If tirzepatide (Mounjaro®) is recommended, you will need to eat a balanced, reduced calorie diet and take part in physical activity regularly whilst taking the medicine. This article provides general health information and does not constitute medical advice. Book your weight management consultation at Chase Lodge Hospital, Page Street, Mill Hill, London NW7 2ED. Our Weight Management Clinic combines prescription medication with expert support from Heather Daniels, our specialist dietitian, providing the holistic approach that research shows delivers the best long-term results. This assessment ensures you receive appropriate treatment and identifies any contraindications that might affect your care. It’s important to know that a cancer diagnosis by itself does not qualify as a reason for treatment with these drugs under the current Food and Drug Administration (FDA) indication (guidance). Dr. Shen cautions that these are early days for these medications with much research yet to do. “It’s projected that by 2030, severe obesity is going to be the dominant weight category in many states across the US. Dr. Shen is a breast cancer oncologist at Memorial Sloan Kettering Cancer Center (MSK) who studies the relationship between obesity, metabolic health, and cancer. Lily "also advises patients to talk to their doctor or other healthcare professional before using Mounjaro if they have ever had pancreatitis," it added. It’s a weekly injection that you give yourself, but it must be part of a weight loss programme and prescribed by a doctor. Tirzepatide (Mounjaro®) is a new medicine that helps people lose weight. Our online weight loss consultation service allows you to access medication from the comfort of your own home. Mounjaro Weight Loss: Week by Week Guide Results seen after 3 months of treatment. What are the most common side effects of Mounjaro? Alongside Mounjaro, our health coaches are here to support you in building sustainable habits in nutrition, exercise, sleep, and mindset. However, after people stopped taking these drugs, they regained around 0.8kg a month, according to the researchers. You may have also seen lots of media coverage about people taking weight-loss injections being at a higher risk of an inflamed pancreas (acute pancreatitis). Speak to your doctor if you’re experiencing any side effects, as you may need to take a lower dose or stop taking them. These side effects affect 1 in 10 people, according to the patient leaflets that come with Mounjaro and Wegovy. But it's only available for people who have a number of certain conditions caused by obesity. Regardless of the mg strength, each mounjaro pen delivers 0.5 ml.If the effects impact your quality of life, you may need to consider an alternative weight loss treatment.Here are eight takeaways from our conversation with Kessler about using the GLP-1 drugs, and the changing landscape of weight loss.Related article Ozempic reduces risk of serious illness and death in people with diabetes and kidney disease, study findsThese medications work by influencing the body’s hormonal response to food intake, slowing digestion, and helping users feel full longer.Early data suggest a similar range of gastrointestinal side effects, potentially with variations in intensity.But, over time, it has shown itself to be a very helpful aid when it comes to losing weight. Of course, if you experience any severe side effects, contact your doctor right away. Your body is incredibly adaptive, and it’s learning a new way of functioning. These small wins signal the medication is working, even when the numbers haven’t caught up yet. This approach recognises that earlier intervention can reduce long-term health risks, rather than waiting until obesity becomes more severe.In other RCTs following up with patients treated with semaglutide, 2.4 mg, adverse effects were reported in 90% of patients over 68 weeks.18 Some possible explanations for the lower reported adverse effects in our study include patients not reaching the maximum dose of semaglutide (ie, 1.7 and 2.4 mg) and the shorter duration of follow-up (24 vs 68 weeks).If tirzepatide (Mounjaro®) is recommended, you will need to eat a balanced, reduced calorie diet and take part in physical activity regularly whilst taking the medicine.In terms of weight loss, in clinical trials people lost up to 20% of their body weight on tirzepatide and 15% on semaglutide.These medications work by imitating a natural hormone that slows digestion and helps individuals feel full for longer.Cost and insurance coverage are often the deciding factors for many, as these determine the financial feasibility of continuing treatment.Mounjaro is a medication that’s specifically prescribed for weight loss.Initially marketed for type 2 diabetes, Mounjaro has been getting widespread attention for its remarkable fat burning properties.If you are no longer able to afford it privately, you may wish check whether you qualify for NHS treatment.This means you may require a diagnosis of diabetes to qualify for Ozempic, or a diagnosis of obesity to qualify for Wegovy. SURMOUNT-1 showed that people on tirzepatide lost an average of 15–20% of their body weight over 72 weeks, with higher doses leading to greater reductions. If needed, this re‐escalation step can be postponed (e.g. for 4 more weeks) and the escalation can be stopped at a lower maintenance dose where AEs are tolerable.20 In patients with type 2 diabetes, blood glucose should be monitored prior to starting and during treatment with semaglutide 2.4 mg.20 Semaglutide 2.4 mg demonstrated better efficacy than liraglutide as well as offering more convenient once‐weekly rather than once‐daily injections.43 Although direct comparisons with other treatments cannot be made because of methodological differences between trials, overall the weight loss with other approved medications appears to be more modest than that seen with semaglutide 2.4 mg in the STEP trials.18, 27, 28, 29, 30, 31 The new treatments are in a class of drugs known as GLP-1 agonists, and this generation of very effective GLP-1 agonists were approved for obesity treatment in the U.S. market in 2021. The number of people using injectable obesity treatments is increasing rapidly, and it is leading to declines in obesity, according to a new survey by the Gallup National Health and Well-Being Index. "It’s an exciting moment after decades of unsuccessful attempts to find effective treatments for people living with obesity." One important factor is Body Mass Index (BMI), which can help determine eligibility for GLP-1 medications like Ozempic, originally developed for type 2 diabetes. GLP-1 medications aren’t given to every patient and are only given to patients when it falls within the FDA approval guidelines for usage. Obtain high-quality GLP-1 medications that have been shown to work, prescribed by licensed physicians when they’re applicable to your health needs. Physician supervised weight loss program including FDA approved GLP-1 medication with lifestyle and behavioral support for lasting results. An estimated 1.5 million people are taking weight loss jabs in the UK, the vast majority of whom pay for them privately. Check with your local integrated care board to check your eligibility for an assessment of whether semaglutide is the right treatment for you.Abruptly stopping the medication may result in spikes in blood sugar, as the drug is no longer helping to regulate them.A significant loss body weight in the tirzepatide group versus the placebo by -9.81 kg (95% CI (-12.09, -7.52), GLP-1 RAs by -1.05 kg (95% CI (-1.48, -0.63), and insulin by -1.93 kg (95% CI (-2.81, -1.05), respectively.The Semaglutide Treatment Effect in People with obesity (STEP) clinical trial programme is evaluating once‐weekly subcutaneous semaglutide 2.4 mg (a glucagon‐like peptide‐1 analogue) in people with overweight or obesity.We’re committed to making healthcare easier, which is why we offer a seamless ordering process that includes fast and discreet delivery.“Every person is different with how fast they respond to losing weight on this medication.Weight-loss response depends on multiple factors, including genetics, baseline weight, medication adherence, dietary changes, physical activity, sleep quality, stress levels, and underlying health conditions.Both manufacturers recommend stopping treatment at least 2 months before a planned pregnancy."It made me feel unattractive. I was just desperate to lose weight." If you are considering one of these versus the other for weight loss, ask your doctor which one they recommend for you and why. Zepbound (tirzepatide) works in two ways while Wegovy (semaglutide) works in one way. You will start at a dose of 2.5 milligrams and adjust it over time to reach the desired effects. While Mounjaro is approved for type 2 diabetes, Zepbound is approved for weight management in adults with a BMI of 30 or more. ‘If total energy intake is low, then it is challenging to get the body to prioritise using this to build muscle. While the study was small (and didn't include women or overweight participants) and much more research is needed, similar responses have already been seen in monkey studies. The results showed an increase in the amount of mitochondrial (mitochondria are the power houses of cells and convert fat and carbohydrates into usable energy) proteins within the muscle, and the speed at which they were being created – signs of a healthier, more efficient muscle. Researchers conducted a small study with 10 healthy, fit young men who completed two five-day experiments in a lab. Indeed, experts have generally issued caution around doing aerobic exercise while in a calorie deficit due to the strain it can place on the body, which may result in breaking down muscle for energy. This approach recognises that earlier intervention can reduce long-term health risks, rather than waiting until obesity becomes more severe. Rare but important side effects such as pancreatitis, gallbladder issues, or changes in blood sugar are uncommon and are monitored closely by clinicians. Over the first few months, weight loss usually becomes more noticeable and more consistent. It contains semaglutide, a medication that helps control appetite and reduce food cravings. We provide simple instructions on how to take your treatment, and will follow up with advice and support on how to manage your weight. Free tools to maximise weight loss People comparing Ozempic and Mounjaro often want a clear answer before starting weekly injections. Losing weight and keeping it off is hard. Your body is adapting, and with support, you can still move forward. The key advantage of private treatment is access to a holistic approach that addresses the underlying factors contributing to weight gain. Our Weight Management Clinic provides comprehensive assessment and treatment for eligible patients. For many people, these criteria present significant barriers to accessing treatment. "Weight regain after stopping treatment may affect the long-term sustainability of the observed benefits. More independent studies from a public health perspective are needed." "We need more data on the long-term effects and other outcomes related to cardiovascular health, particularly in lower-risk individuals," says Eva Madrid, co-lead researcher from the Universidad de Valparaíso, Chile. Costs remain a major barrier, particularly for semaglutide and tirzepatide, while liraglutide has become more affordable since its patent expired. GLP-1 drugs show promise for weight management These medications work by imitating a natural hormone that slows digestion and helps individuals feel full for longer. If you’re using another weight loss medication, such as Wegovy, you’ll need to wait up to 4 weeks before switching to Mounjaro. Mounjaro is a revolutionary new once-weekly injectable weight loss medication that can help you lose weight. Studies have shown that these agents can decrease glucagon and promote weight loss, but as of now, there isn’t enough data available to support the use of these drugs in type 1 diabetes patients. Some people experience weight loss and appetite changes immediately, whereas it can take a few weeks for others to see noticeable differences. Having launched in the UK in February 2024, it may be even more effective than other weight loss drugs like Wegovy and Ozempic. Semaglutide is a tried and tested medication, prescribed for weight loss under the brand name Wegovy. Advanced, clinically-proven medications. Exercise Recommendations While Taking GLP-1 Medications At week 6, the weight loss seen in the research was about 5-6% of starting weight. The first few weeks are also important for establishing the habit and routine around taking your medication. You should consult a healthcare professional before taking any medications at the same time as Mounjaro. Everyone experiences the medication differently, and some people won't experience side effects at all, but you may start experiencing common side effects at this time, to varying degrees of intensity. It's important to allow your body time to get used to the medication, and the best results are seen once you reach higher doses in future months. “I counsel patients on adopting anti-inflammatory diets, engaging in enjoyable and consistent physical activity, and addressing psycho-social factors. “We hadn't learnt yet at the time that the curve is important,” Hashemi adds, explaining how “the risk and rewards of these drugs change based on how long you can keep the effect. The first time I was on Mounjaro, I got off it too quickly after hitting my goals – which means I just mistakenly dropped the drug from a high dose to nothing,” he says. “ The danger is people are seeing these injections as like a magic needle. Hello, I'm about to start taking Mounjaro tomorrow on the starter dose of 2.5mg, and wondered if any of you who have been taking it for a while can tell me how soon the effects kicked in. And does it work better for weight loss than Ozempic and Wegovy? There is some evidence Zepbound might lead to more weight loss than Ozempic. These drugs are generally considered safe, but they do have possible side effects. But we need more research to really understand the differences over the long term and how taking either one of these drugs affects your health. In line with regulatory guidance, the STEP trials were designed to report results using two estimands.45 The treatment policy (primary) estimand assessed effects regardless of treatment discontinuation or rescue medication, while the secondary trial product estimand modelled treatment effects in all randomly assigned participants, assuming they had remained on treatment for the duration of the trials, and without initiation of rescue medication.Beyond just a weight goal, you might also want to think about other aspects of your general health you want to improve.Before their first medication dose, the average weight for people in both groups was 243 pounds.News he was already missing the body he had when he was still taking the weight-loss drug.The study was relatively large and diverse, including 751 people without type 2 diabetes and either a BMI (body mass index) of 30 or above, or a BMI of 27 or above and at least 1 obesity-related health problem like high blood pressure or high cholesterol.Each dose administers 0.6 ml of liquid, but how much of the active ingredient is present in each depends on which pen you have.If you do experience any side effects, most of them are minor and temporary. Understanding these differences can guide your treatment plan and optimize outcomes in your weight loss journey. The effects of Mounjaro extend beyond simple appetite suppression, influencing multiple aspects of body composition and health. Clinical trials have shown significant weight loss results among users, often leading to improved body composition. Fatigue and headaches occur in 10-15% of users, often related to reduced calorie intake rather than the medication itself. Nausea affects 30-40% of users initially but usually responds well to dietary modifications and slower dose escalation. Always verify coverage before starting treatment, as retroactive claims are typically denied. Private weight management clinics offer immediate access but require careful selection to ensure safety and legitimacy. In March 2024, his health journey appeared to take a surprising turn. In August 2023, the 30 Rock alum said on Today With Hoda and Jenna that he lost weight on Ozempic because it supressed his appetite. She added, "But you'll never hear a second of judgment from me about people who choose that direction!" The Jon & Kate Plus 8 alum told Page Six in April 2024 that he lost 32 pounds in two months after taking injections of semaglutide, the generic form of Ozempic. My face was clenching up, my whole body was tense.” Science shows that weight-loss medications should be combined with lifestyle changes. While on Mounjaro, a special diet isn’t strictly required, but following a balanced, protein-rich diet can enhance weight loss and overall health. Balancing diet, physical activity, and ongoing support is crucial to maintaining weight loss and preventing rebound gain following discontinuation of the medication. Consider how Mounjaro can fit into your weight loss journey alongside healthy habits and regular physical activity for optimal results. This innovative medication targets body weight management by addressing both appetite regulation and blood sugar control. For those contemplating a treatment plan tailored to weight loss, exploring the details of Mounjaro is crucial. Embarking on your weight loss journey with Mounjaro can lead to significant results, influenced by various factors such as diet, physical activity, and underlying health conditions. Clinical trials have shown that taking either semaglutide or tirzepatide can make you lose weight. But many people might lose closer to 10% of their body weight. While they are approved for diabetes, both Mounjaro and Ozempic also make people lose weight by helping you to feel full longer. While both Mounjaro and Ozempic are really diabetes drugs, they also can help you lose weight. There’s more data on Wegovy for weight loss, but Wegovy also comes with a longer list of common side effects given the higher dose. Key inclusion criteria for the STEP 2 trial were age ≥18 years, type 2 diabetes diagnosed ≥180 days prior, BMI ≥27 kg/m2, HbA1c 7%‐10% (53‐86 mmol/mol) and treatment with diet and exercise alone or stable treatment with metformin, sulphonylurea, sodium‐glucose co‐transporter‐2 inhibitor, glitazone as single‐agent therapy or ≤3 agents for diabetes according to local label. In these trials, 46%‐76% of participants lost ≥5% and 23%‐37% lost ≥10% of their baseline body weight.18, 32, 33, 34, 35 Overweight teens become overweight adults, which puts them at high risk for developing other health problems. It's easy to lose 2 lbs per week or more by dieting only two days a week. Wegovy vs. Zepbound side effects At the same time, there is growing evidence that tirzepatide plays a role in the weight loss of T2DM patients. GLP-1RAs are now considered the choice of injectable therapy for many people with T2DM and obesity, with several members of the class having weight loss efficacy 11–13. Additionally, more evidence supports the use of the GLP-1RAs semaglutide in people with obesity without type 2 diabetes mellitus (T2DM) . Thus, weight loss can reduce the incidence of cardiovascular events and all-cause mortality in cardiovascular patients 3, 4, and lessen the incidence of diabetes 5, 6. Discontinuation was common — more than half of patients stopped their treatment before the end of the study — but rates were similar among those taking tirzepatide and those taking semaglutide. 'This is the main reason some patients feel weaker or more fatigued.' 'GLP-1s slow gastric emptying and reduce appetite, so people often end up consuming too few calories and become unintentionally under-fuelled,' says Dr Ajaz. 'Aim for moderate intensity – where you can speak a few words while working out but not sing.' However, she adds, 'always consult your healthcare provider before starting any new exercise programme, especially if you have underlying health conditions.' ‘Those who have built muscle before, but lost it, are likely to find that their body responds better to strength training, thanks to “muscle memory”, and those who are carrying larger amounts of excess body fat, as the body can use stored fat as an energy source to help fuel muscle growth.’ These might include feeling sick or throwing up, or other side effects that come with Mounjaro—like constipation or diarrhoea. Because Mounjaro can stay in the body for up to five days, they’ll need to keep an eye on you and manage any symptoms that come up. But if it’s been more than four days since your missed dose, skip it and take it again on your usual day. So, if you normally take it on Monday but you realised you forgot on Wednesday, you’d take that dose right away—and your next injection would be the following Monday. How many doses are in a Mounjaro pen? In all groups of patients, they should be used alongside a reduced-calorie diet and regular exercise. Mounjaro is typically injected once a week, and Wegovy is also a once-weekly injection. Wegovy (semaglutide) functions primarily as a GLP-1 receptor agonist that increases insulin production, decreases glucagon secretion, and slows down gastric emptying. This dosage is for treatment initiation and not intended for glycemic control. The recommended starting dosage of Mounjaro is 2.5mg injected once a week under the skin. If you have struggled with weight loss in the past, particularly weight loss after 40, these medications can provide the metabolic support needed to break through plateaus. For treatment to be effective, weight loss injections UK guidance emphasises the importance of combining medication with lifestyle changes. Most private providers require patients to be aged 18 or over with a BMI of 30 or above, or 27 or above with weight-related health issues such as high blood pressure, type 2 diabetes or high cholesterol. It works by mimicking GLP-1 alone and typically produces weight loss of 15 to 17 per cent over 68 weeks. Research published in the New England Journal of Medicine found participants taking Mounjaro lost an average of 20.2 per cent of their body weight over 72 weeks, compared to 13.7 per cent for those taking Wegovy. Most of the studies included in the reviews were funded by the companies that manufacture the drugs and were shaped by those companies in terms of design, analysis, and reporting. The reviews found little to no difference between the drugs and placebo when looking at major cardiovascular events, mortality, or quality of life. Even so, there is still limited or uncertain evidence about their long-term safety, possible side effects, and how financial ties might influence study results. In emergencies, call 911, or seek care from a local hospital or mental health provider. If you titrate up to the maximum maintenance dose of Mounjaro, you’ll inject 15 mg once weekly. The term ‘maintenance dose’ refers to the strength of medication you’ll stay on for the majority of your journey. To help you safely reach the maximum and most effective dosage, while also enabling your body to adjust to the medication, it’s important to gradually increase the potency of your injection. In the study, the researchers wrote that this may be because living with excess weight or obesity is a risk factor for many diseases, including heart attacks or strokes. However, people taking GLP-1 agonists also had a higher risk of 19 side effects or diseases compared to those receiving their usual medicines. Dr. Sethu Reddy, president of the American Association of Clinical Endocrinology, said the primary side effect of the medications is nausea. After the medication is fully administered, another click will let you know it’s done. Refrigeration prevents the active ingredients from breaking down, ensuring the medication works properly and is safe. If you missed a dose in the past four days (or fewer), take it immediately. If you miss a dose of Mounjaro, the steps you must take depend on the number of days since your missed dose. As time goes on, an increasing number of drugs have been developed for the treatment of T2DM or obesity. Currently, a growing number of drugs are used for weight loss, such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). A significant loss body weight in the tirzepatide group versus the placebo by -9.81 kg (95% CI (-12.09, -7.52), GLP-1 RAs by -1.05 kg (95% CI (-1.48, -0.63), and insulin by -1.93 kg (95% CI (-2.81, -1.05), respectively. Tirzepatide and semaglutide both mimic the effects of the gut hormone GLP-1, which stimulates the body’s production of insulin and slows the passage of food through the stomach. Here we share a rough weekly guide for your first eight weeks and beyond, the benefits you’ll start to see, and how you can use this time to establish good habits. 3 Tirzepatide for managing overweight and obesity. As with any medication, there are a few side effects to be aware of. At Numan, our Weight Loss Programme is crafted by a team of dedicated experts in the fields of obesity management, behavioural change, and metabolic health. Research shows that without established lifestyle changes, people typically regain around two-thirds of lost weight within a year of stopping medication.You should always provide a full and honest medical history alongside a note of any prescription and non-prescription medications you’re taking.But the weight loss results were game changing in that trial already.Clinical trials suggest that Mounjaro is an effective treatment for supporting weight loss.Additionally, more evidence supports the use of the GLP-1RAs semaglutide in people with obesity without type 2 diabetes mellitus (T2DM) .People in England over the age of 18 living with obesity and weight-related health issues, will be able to access the weight loss drug tirzepatide (Mounjaro®).After sharing his goal weight was 270 pounds, Barkley added, "My doctor told me, she says, there's a lot of fat young people. Ain't a lot of fat old people, they're all dead." The medication starts to work after the first dose, but the effects on weight loss won’t be immediate. GLP-1 agonist medications may be a suitable option for many patients and could produce comparable results, at least in the short term, to some weight loss procedures e.g. gastric balloon. We also know that the body compensates for weight loss by lowering energy expenditure (metabolism) over time, so it can be reasonably expected that prolonged treatment with these drugs is required to be most effective. Since Ozempic and Mounjaro are currently only approved by the TGA for the treatment of type 2 diabetes, there may be significant financial and access barriers to any patients wanting to use these for weight loss. Becoming known as ‘obesity wonder drugs’, many people are opting for these types of medications as less invasive and cost-effective alternative to endoscopic procedures or bariatric surgeries. And the National Institute for Health and Care Excellence (NICE) recommends eating a reduced-calorie diet and taking more physical activity while using weight-loss injections.Alongside Mounjaro, our health coaches are here to support you in building sustainable habits in nutrition, exercise, sleep, and mindset.Tirzeptide is a novel glucagon-like peptide-1 receptor (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) drug, which shows good efficiency for weight loss.They help manage blood sugar levels while also supporting weight loss.Improvements in measurable health metrics e.g. reduced blood pressure, improved cholesterol or blood glucose controlFor more information, including what to do if you have any side effects, see Section 6.If prescribed, it’s important that Mounjaro® is used alongside healthy lifestyle changes, such as more physical activity and a reduced calorie diet. Because every gram of glycogen is stored with 3g of water, when the energy is released, so too is the water, which will leave your body as waste in urine, stools, and sweat. When you eat fewer calories, your body releases glycogen, your stored energy, to replenish the energy it’s not getting. It’s a self-injectable solution that contains the active ingredient, tirzepatide, and can produce impressive results. These shifts typically stabilize over time, but are worth tracking since they provide clues about how your body responds to treatment. Pay attention to changes in your body beyond just weight. This mental freedom feels revolutionary for many people who’ve spent decades struggling with food and weight. This rollercoaster tends to stabilize as weeks pass. Most patients experience less hunger and feel full faster because of the way GLP-1s affect the body’s natural hunger mechanisms. Mounjaro won’t be as effective on its own, so you’ll need to commit to changing your lifestyle to accompany the weight loss medication. A 5% weight reduction is believed to have a clinically meaningful effect on metabolic health. If you have remained on the lower doses for longer, then it will take longer than 21 weeks to reach the highest maintenance dose. But are GLP-1 side effects bothering you too much?Remember that these medications are tools to support weight loss, not magic solutions; they require commitment to dietary changes and increased physical activity for optimal results.He added further research was needed "to make sure that these drugs do not increase the risk for non-obesity-related cancers".Research in Europe suggested these drugs could lead to suicidal thoughts, perhaps because these medications affect brain pathways responsible for hunger signaling.By taking control of your health and adopting a healthier lifestyle, Mounjaro can boost your confidence, reduce anxiety, and improve mental clarity.This guide will take you through the different dosages of Mounjaro and how the dose you’re prescribed might change throughout your treatment journey.We offer a price match scheme on GLP-1 medication to help keep your costs down whilst still getting access to our treatments and clinical support.Research shows that patients who develop healthy habits alongside medication tend to maintain more weight loss after stopping. Recently approved by the MHRA for weight loss, Mounjaro (tirzepatide) represents a significant breakthrough in treatment for those overweight or obese. Over the next few months you should start to experience more weight loss as your body responds to the treatment. Mounjaro patients can expect to lose around 21% of their starting body weight over the course of 18 months. During the first month, the medication takes time to reach what doctors call a ‘steady state’ in your body, typically within 4-5 weeks. Research suggests that tirzepatide could be more effective for weight loss than semaglutide (Wegovy). The University of Oxford researchers found people lost 14.7kg after taking newer weight-loss medicines, such as Wegovy and Mounjaro, for around 9 months (39 weeks) on average. Another serious limitation is the exclusion of patients who did not reach 3 months of follow-up, which might have resulted in an overestimation of the association of semaglutide with body weight. With proper dosing, he said, the patients on Ozempic would have seen better results. Dr. Ken Fujioka, an endocrinologist who leads the Scripps Clinic Nutrition and Metabolic Research Center in San Diego and who was not involved in the study, noted that the FDA approved a higher dose of Ozempic in March 2022 but that many doctors were not aware of that during the study period. The researchers didn’t examine the biological mechanisms of the two drugs, but study leader Tricia Rodriguez, a principal applied scientist with Truveta Research, said Mounjaro may have been more effective because it works two ways instead of just one. The result was a population of nearly 18,400 who were evenly split between the two drugs. The Truveta team found about 41,000 people across more than 30 states who met all their criteria for being included in the study. Rebel Wilson tried Ozempic to guide herself through her "year of health" journey. "No, I don't look like I did 10 years ago. I've been on a journey to be the healthiest, strongest version of myself for my kids and for me," she shared on Instagram. Meghan Trainor debuted her glow-up after losing weight. Lizzo consistently dismissed the weight-loss drug rumors amid her journey. "I started the weight-loss shots," the former Playboy model revealed in an Instagram post in April. Dr. Niles is a licensed physician with over 30 years of clinical experience who provides physician-guided weight loss consultations centered on personalized care. We only dispense FDA-approved GLP-1 medications for FDA-approved indications, and you can be confident that you’re receiving proven, safe, and effective treatments. Speak to licensed medical professionals who will address the health history, and help you determine if GLP-1 medications are appropriate for you. We follow a simple 3-step process where we connect you with a licensed healthcare provider for a weight loss program evaluation, where you receive clinician-guided care from home. If you or someone you know may be experiencing a mental health crisis or contemplating suicide, call or text 988. If a person taking these drugs notes a depressed mood or change in anxiety level, they should discuss it immediately with their provider. However, this side effect was rare, and the FDA concluded the drugs presented no concerns about suicidal ideation. Nonetheless, this is an important risk/benefit discussion for people to have with their doctor. Other recent research suggests that patients with another form of the disease—called differentiated thyroid cancer—GLP-1s do not increase risk of the disease recurring or progressing. With the help of their database, the researchers were able to spot people who filled their first prescription for either drug between May 2022 — the month Mounjaro joined Ozempic in receiving FDA approval — and September 2023. Researchers from Truveta, a healthcare data and analytics company owned by 30 health systems, sought to remedy that by examining their trove of electronic health records. Tirzepatide, the active ingredient in Mounjaro, appeared to be more effective than semaglutide, the active ingredient in Ozempic. By mimicking a hormone called glucagon-like peptide 1, or GLP-1, they boost the body’s production of insulin, slow digestion, increase feelings of satiety and reduce appetite. Participants were randomized to receive once‐weekly subcutaneous semaglutide 2.4 mg or matching placebo for 104 weeks. STEP 441 was a 68‐week withdrawal trial, designed to assess the effect on weight change of continuing versus discontinuing once‐weekly subcutaneous semaglutide 2.4 mg after an initial 20‐week semaglutide run‐in period. The aim of this review is to describe the study designs and clinical outcomes of the published trials from the STEP programme, discuss clinical implications of the data and practicalities of using semaglutide 2.4 mg in individuals with obesity and place the STEP programme into the context of the current and future obesity pharmacotherapy landscapes. With over forty years of experience helping patients lose weight, Dr. Lipman has treated more than 1,200 patients using GLP-1 injections across Miami and throughout Florida via Telemedicine. Each of these factors carries substantial weight in the decision-making process, hence the importance of a personalized approach in selecting the right weight loss medication for each individual.