With the vast array of PCOS supplements available, it can be slightly overwhelming to choose the right ones for you. Based on the specific symptoms you may be struggling more with, targeted supplement use works best. You may have made several changes to your lifestyle in hopes of seeing improvements in your PCOS symptoms. Although probiotics, prebiotics, and synthetic agents have emerged as potential supplements, their role in PCOS remains poorly understood. The combination of myo-inositol and metformin demonstrated clear clinical benefits in women with PCOS undergoing induction cycles (80). Your PCOS health journey does not need to be confusing or overwhelming. Yes, it is generally considered safe to take berberine and inositol together. One study of 150 infertile women found that taking berberine 3 months prior to IVF led to higher pregnancy rates than metformin or the placebo group. It is important to note that there is also research that supports berberine for fertility. The identified studies also had moderate to high risk of bias and were generally small with significant drop-outs. Many of the included studies did not report numeric differences between groups and relevant data could not be extracted. Additionally, this systematic review was limited to studies in English. Chronic stress doesn’t just impact your mood – it can increase cortisol levels, worsen inflammation, and throw your cycle further off track.Probiotics help restore healthy gut flora, which may improve mood, digestion, immunity, and even weight management.Low levels may be linked to several common traits of PCOS, like insulin resistance and higher levels of androgens.If you’re not an oily fish lover, you may want to consider a quality fish oil supplement, such as this one by Nordic Naturals.Reducing stress can help lower cortisol levels, which may aid in weight loss.These can make weight gain and hormonal imbalances worse.Not only can it help with insulin resistance caused by PCOS, but it can also reduce inflammation and minimize PMS symptoms. Yes, many women combine Inositol, Omega-3s, and Vitamin D safely. Supplements won’t show magic results overnight but will support your journey when used long-term. Supplements are supportive tools. These factors can make traditional diet and exercise routines less effective. Since omega-3 fatty acids are strong antioxidants in their natural state, it has been discovered that they can reduce inflammation. Join our sanctuary to heal and transform your health, balance your hormones and revitalize your life! You can also let your doctor know which supplements you will be taking. Choose which supplements are best for you, then follow the manufacturer’s instructions on the bottle for the daily recommended amount to take. This valuable resource is tailored for healthcare professionals, nutritionists, and individuals with PCOS seeking evidence-based guidance on effectively managing this complex condition through optimized nutrition. As PhD students, we found it difficult to access the research we needed, so we decided to create a new Open Access publisher that levels the playing field for scientists across the world. People who take this supplement score better on glucose tolerance tests. However, the right supplements and lifestyle changes can be HUGE for your wellness goals! Polycystic ovary syndrome (PCOS) can impact your whole body and make it really hard to lose weight. So, balancing those androgens is essential to getting control of your weight and overall health. While that may sound scary, I believe knowledge is power and there are definitely steps you can take to lower your risk of diabetes and other health conditions. Then we’ll dive into steps you can take that will help you to lose weight with PCOS. Rest assured though, it’s not impossible to lose weight with PCOS…you’ll just need to understand how to lose weight with PCOS effectively. That seems like the most popular question I’m asked as a registered dietitian that specializes in PCOS. She specializes in liver enzyme abnormalities, fatty liver disease, hepatitis, cirrhosis, and digestive health. In the study, women with PCOS ate less olive oil, beans, fish, and nuts and more simple carbs and total fats than the control group. A crash diet won’t get you there; treatment requires a multifactor approach and time to build new lifestyle habits. It impacts up to 20% of women during the reproductive years, from puberty to menopause. Despite what diet culture says, carbs are not the enemy in PCOS. There’s no need to avoid dietary fat—in fact, it’s essential. Lifestyle Changes NAC is a powerful antioxidant that helps reduce oxidative stress in the body. Ashwagandha is an adaptogenic herb that helps the body manage stress. Magnesium is a crucial mineral for overall health and is particularly beneficial for managing stress and anxiety. This blog will serve as your PCOS supplement cheat sheet, highlighting the essential nutrients you need to manage PCOS effectively. She didn't want other women to suffer as long as she did which is why she has dedicated her life to helping women in the same position as she was. No statistically significant differences in weight or weight loss following the intervention were found between women with and without PCOS in five studies, with the remaining studies not comparing the difference in weight or weight loss between these groups. Platforms such as Oana Health offer treatments grounded in science, tailored to tackle common PCOS-related issues like weight management, insulin resistance, and hormonal imbalances. However, it's important to consult a healthcare provider before making major dietary adjustments or introducing supplements. Recent studies highlight how diets rich in micronutrients can play a transformative role in managing weight for women with PCOS. It is especially useful if you’re trying to get pregnant and helps with mood and fatigue in addition to reducing high homocysteine levels. Folate or Vitamin B9 also helps regulate the amino acid homocysteine and lower inflammation. Some people call magnesium the miracle mineral due to its involvement in over 300 chemical reactions in the body and its role in the proper growth and maintenance of bones. May interact with certain medications, such as blood sugar medications and blood-thinning medications. NAC also helps regulate your menstrual cycle by promoting hormone balance and liver detoxification. Gut health and hormone health are more connected than most people realize.Always consult with a healthcare provider to determine the right dosage and combination of vitamins for PCOS weight loss to suit your individual needs.It’s been shown that high levels of stress can worsen PCOS symptoms, linked to weight gain.There are now several options for supplements for PCOS that help with weight reduction goals, which have recently received a lot of media attention.Remember that weight loss looks different for everyone and try your best not to compare your journey to anyone else’s.It can lower cortisol levels and improve symptoms of anxiety and depression, making it a valuable supplement for women with PCOS.In fact, studies have shown inositol may be just as effective with fewer side effects.It seems to specifically reduce central body fat, which is the type most seen in PCOS; however, the results of most studies are underwhelming when it comes to actual weight loss. Similar to prescription medications, dietary supplements can sometimes give you the boost you need to really manage your symptoms though. Most natural supplements for PCOS weight loss are safe when used correctly. Losing weight with Polycystic Ovary Syndrome (PCOS) can be tough, especially when hormones and insulin resistance make progress slow. Rather than stacking a handful of separate supplements, consider simplifying your routine with one or two high-quality supplements that support your hormones. Despite the conflicting fertility outcomes, myo-inositol has been found to shorten the duration of controlled ovarian hyperstimulation during IVF procedures (34). Myo-inositol is a natural molecule present in fruits and vegetables that participates in FSH signaling, which orchestrates ovulation (30). Moreover, the molecular properties of anti-sperm antibodies binding to vitamin D-binding protein (VDBP) raise questions regarding their role in implantation (25). Focus on supplements that have proven successful in helping you lose weight. Depending on your prior vitamin B levels, you may gain weight, lose weight, or stay the same. In multiple studies, cod liver oil did not specifically cause weight reduction, but it did improve waist circumference in those who took it. This supplement is one of the top recommendations for those looking into the best supplements for PCOS weight loss. For those struggling with PCOS, inositol offers a natural and safe way to manage symptoms and promote weight loss. By improving the way your body processes glucose, inositol helps reduce insulin levels, which can decrease fat storage and cravings. Individual supplements allow for personalized dosing and targeted addressing of specific symptoms—you can adjust each component based on your body's response. Additionally, stimulant-based weight loss supplements often worsen adrenal stress and can be counterproductive for PCOS in the long run. Its pathophysiology involves genetic, environmental, and hormonal factors, disrupting the HPO axis and contributing to reproductive and metabolic complexities. Prioritizing overall well-being and mental health is a personal choice, offering valuable steps toward a more fulfilling life 29, 32. This encompasses regular behavioral adjustments, social support, and psychological adaptations. Lifestyle adjustments play a crucial role in managing PCOS in women, complementing medical treatments. Stress can make inflammation worse, which can worsen PCOS symptoms like acne and irregular periods. Stress also increases cravings and appetite, making weight loss harder. A personalized workout plan helps women with PCOS manage their health better. Fiber and magnesium are helpful supplements for appetite control. These make losing weight harder compared to women without PCOS. “I was given an explanation of how my hormonal imbalance was affecting me as a whole - body & mind - & tools so that we could start to manage my condition. Not all supplements are created equal, and with PCOS, quality matters. What PCOS Blood Tests Should Be Done for Best Management Outcomes? Vitamin D deficiency is quite common among women with PCOS. Check out our recipe for a low-sugar blueberry and spinach frittata for a healthy start. Supplements work best when combined with lifestyle changes like exercise, a balanced diet, and stress management. Managing Polycystic Ovary Syndrome (PCOS) often involves making key dietary and lifestyle changes. Banana, rice, curd & Indian diet tips to stop diarrhoea, prevent dehydration... Studies have demonstrated elevated levels of pro-inflammatory markers, including TNF-α, IL-6, and C-reactive protein, in women with PCOS. Key compounds such as inositol (particularly myo-inositol and D-chiro-inositol), omega-3 fatty acids, vitamin D, chromium, and Coenzyme Q10 have emerged as potential therapeutic agents. The condition’s impact on insulin signalling and glucose metabolism creates a particularly challenging environment for weight management, necessitating targeted interventions that address these underlying metabolic disruptions. Although diet trends shift over time, the role of protein in our appetite control, metabolism and body composition has remained Read more… While a lot of these supplements may not drastically increase your hair growth, deficiencies in vitamins such as biotin have been recorded among those women who have hair loss and thinning. The active form of inositol, myo-inositol, helps with insulin resistance, which is a key factor in PCOS-related weight gain. A meta-analysis of 15 clinical trials showed a statistically significant drop in body mass index (BMI) when inositol was used for PCOS weight loss. Q. How long does it take for PCOS diet supplements to work? Women with PCOS often face challenges like insulin resistance, hormonal imbalances, and slow metabolism. They aid in controlling blood pressure and blood sugar levels and, if you’re overweight, they can aid in losing weight. Losing weight with PCOS is like running a marathon, not a sprint. Your brain needs darkness to create melatonin, your natural sleep hormone. Did you know poor sleep and high stress can mess with your hormones as much as junk food? Here’s how to boost your supplement results with a few simple lifestyle tweaks. Let’s dig into what PCOS supplements work (and what doesn’t). Polycystic Ovary Syndrome (PCOS) is a complex hormonal condition that affects about 1 in 10 women of reproductive age – though many go undiagnosed for years. As a registered dietitian who specializes in PCOS, I’ve helped hundreds of women cut through the noise and find simple, evidence-based strategies that actually work. If you’ve ever found yourself staring at a shelf of supplements – or scrolling through endless TikToks – wondering which ones actually help with PCOS, you’re in good company. This type of diet helps regulate insulin levels, which is crucial for managing symptoms, maintaining a healthy weight, and supporting hormonal balance. Find out how these nutrients can help improve insulin sensitivity, balance hormones, and support healthy weight loss for women with PCOS. PCOS supplements containing nutrients, particularly vitamins, minerals, and antioxidants, play a crucial role in managing its symptoms, including insulin resistance, inflammation, and hormonal imbalances. The right supplements can help balance hormones, improve insulin sensitivity, and support metabolism, making weight loss more achievable. Last but not least, many health and wellness experts believe that everyone should take a multivitamin to ensure they're getting in all their daily recommended levels of nutrients. High-dose vitamin A supplements may worsen liver function, which can already be compromised in PCOS. These supplements work best when combined with targeted exercise like strength training and a low-glycemic diet. Several supplements may help address the hormonal factors that contribute to PCOS-related abdominal fat. As you get healthier and begin to manage your disease more effectively, weight loss will be much easier. In addition, many of them actually make insulin resistance worse, which will cause you to gain back all lost weight and then some. Metformin often helps not just with weight loss, but with many of the symptoms of PCOS. Several studies have found that these two effects help women with PCOS to lose weight more easily, especially if they are currently obese. Metformin is a diabetes medication that helps the human body process insulin and glucose in a healthier manner. Choline supplementation improved ovarian function in a pig model. Inositol lowers insulin resistance, improves reproductive function, improves oocyte quality and restores ovulation in patients with PCOS. Further long-period studies are required to confirm the effects of CoQ10 supplementation on inflammatory factors in PCOS 60, 66, 67. In adolescent girls with PCOS, combined inositol treatment significantly reduced concentrations of HMGB1 and insulin to levels almost similar to those of controls. Chronic low grade inflammation may contribute to different ovarian alterations as well as insulin resistance 34, 57-59. Mira Hormone Monitor: Max Kit Start by reviewing your current vitamin and supplement routine and see where you can make improvements. Pair these supplements with a balanced, low-glycemic diet and regular exercise to enhance their effectiveness. Regular physical activity, a balanced diet, and stress management are crucial for achieving and maintaining weight loss with PCOS. While vitamins for PCOS weight loss can significantly aid in weight management, they are most effective when combined with complementary lifestyle changes. Yes, you can take multiple vitamins for PCOS weight loss simultaneously, but it’s essential to ensure they complement each other and do not exceed recommended doses. From the authors’ own studies, those that corresponded sequentially to the intervention steps discussed were selected. Undoubtedly there is a need for further research to be undertaken to determine the efficacy and applicability of the ingredients described as a support for traditional PCOS management. The analysis of metabolic symptoms occurring in the course of PCOS points to the need for a multidirectional therapeutic approach. The selection of the appropriate mixture may be individualized depending on the occurrence of symptoms. To summarize, herbs and the substances they contain offer many possibilities for interventions supporting the treatment of PCOS at various stages of disease. Anti-androgen supplements Magnesium can also be taken supplementally to increase levels if dietary intake is low. Magnesium is a nutrient involved in many processes in the body, including regulating blood sugar and blood pressure, nerve and muscle function, protein synthesis, and bone health. Curcumin has been shown to improve glycemic control by decreasing fasting blood glucose and increasing insulin sensitivity in patients with PCOS. While individual supplements like inositol, NAC, or berberine can be helpful, trying to juggle multiple bottles and track dosages every day can feel overwhelming. One or two high-quality supplements can provide several hormonal benefits. Often called the “sunshine vitamin,” vitamin D plays a crucial role in hormonal regulation, insulin sensitivity, and even mood regulation. While diet and exercise are crucial, incorporating the right vitamins for PCOS weight loss into your regimen can significantly enhance your efforts. Start with 1-2 supplements targeting your main issues (e.g., inositol + vitamin D). In this article, we’ll explore evidence-based PCOS supplements for weight loss, their mechanisms, dosages, and precautions. Not only will it make you more prone to overeating and less likely to get the exercise that you need, it also has been found to worsen insulin resistance. This can be especially destructive to women with PCOS who are trying to lose weight. Learning to deal with stress in a healthy way is not just good for your mind, but good for your body as well. The recommended amount of inositol for women with PCOS is 4 g per day (in the morning and in the evening, preferably). I like to use Ovasitol because it was formulated to improve egg quality and balance insulin. In addition to this, it can be very beneficial to take Inositol supplements. How to Choose the Right Vitamins for PCOS Weight Loss Eating a high-fiber diet helps you feel full, which can help control calorie intake.We will also talk about how a PCOS nutritionist can help you decide which supplements might be best for you and how to incorporate them into your diet.While whole foods are the cornerstone of good nutrition, supplements can be essential in certain situations.This hypothesis is substantiated by the concurrent increase in rates of diabetes, heart disease, and PCOS, aligning with the swift changes in the modern human diet.Discover the underlying causes of a white tongue, including vitamin deficiencies, gastrointestinal issues, infections, a...However, it is very important for women with this syndrome to achieve a healthy weight, as this reduces the severity of PCOS symptoms.Additionally, hormonal imbalances such as elevated androgens (male hormones) can disrupt fat storage and appetite regulation, making weight management more strenuous. Many people believe that they need to get a gym membership or get out and sweat buckets in order to lose weight. Many diet gurus suggest a cup of tea at night to stave off late night eating. This makes it harder to lose weight over the long term, so choose water instead. Having a strong support network is key for those dealing with PCOS. Improving sleep quality is crucial for women with PCOS. So, women with PCOS should aim for 7 to 8 hours of quality sleep each night. For example, inositol is often divided into 2-3 doses with meals to enhance uptake (Unfer & Porcaro, 2021). While timing wasn’t specifically addressed in the article, research suggests spreading supplement intake throughout the day may optimise absorption. The research indicates that successful PCOS weight management requires a multi-faceted approach. Which prenatal vitamin is best for you will depend on your unique needs and your current diet. If you’re not trying to conceive, a prenatal vitamin may still be a good option as a multivitamin to help fill in nutrient gaps in your diet. As important as zinc is, we also know women with PCOS are more likely to have low levels of zinc. Probiotics are the good bacteria that can help to improve gut health. We often think about probiotics as a way to improve digestion or stomach issues, but more research continues to show us how instrumental our gut is for overall health. Whenever possible, consult a healthcare provider, functional medicine doctor, or registered dietitian familiar with PCOS before starting anything new. It's also best to avoid stacking too many supplements without a clear reason. Some “hormone-balancing” herbs like dong quai, black cohosh, or vitex (chasteberry) can interfere with other medications or worsen symptoms if taken incorrectly. A good quality multi-strain probiotic—especially those containing Lactobacillus and Bifidobacterium species—can be a solid foundation for overall hormone support. Gut health and hormone health are more connected than most people realize. Research has also demonstrated that supplementing with fish oil can help improve ovulation, ovarian reserve, and overall fertility. Safety aside, several vitamins and minerals help regulate hormonal imbalances and promote ovulation, which can be especially helpful if you have PCOS. Women with PCOS have high levels of androgens, or male sex hormones, as well as an imbalance of estrogen and progesterone. PCOS is characterized by hormone imbalance and blood sugar regulation problems. Myo-inositol effectively reduced postprandial triglyceride (TC) levels, glutathione peroxidase (GSH-Px) activity, liver fat accumulation, and aspartate aminotransferase (AST) levels (32). Myo-inositol and D-chiro-inositol are the two most clinically important isoforms of inositol; as secondary messengers of insulin, an imbalance between them is key to IR (29). Moreover, vitamin D regulates metabolism by reducing malondialdehyde (MDA) and high-sensitivity CRP levels while increasing TAC (24). Vitamin D alters serum AMH signaling, progesterone release, and follicle-stimulating hormone (FSH) sensitivity in in vitro studies (21). You should consult with your physician or other health care professional before making any decisions or taking any actions based on this content. Discover the purpose, uses, indications, and side effects of progesterone suppository in detail, including its role in supporting pregnancy and what to expect. Discover what it means to have creamy, cloudy, or milky white discharge during your menstrual cycle, ovulation, and pregnancy, and when to consult a healthcare provider. The increased oxidative stress caused by inflammation and bacterial action leading to acne can benefit from the detoxification process through glutathione production following the use of N-acetylcysteine. However, it’s important to avoid excessive zinc intake, as too much zinc can be toxic to the body and may cause adverse effects. Many women with PCOS have low magnesium levels, which can lead to higher stress hormones, poor sleep, and sluggish metabolism. Not all supplements are worth your time, but these five are backed by science and specifically target PCOS-related weight struggles. While no supplement can magically melt fat, targeted nutrients can make weight loss easier and more sustainable. Losing 5 to 10% of body weight can help regularize menstrual cycles and improve health. We'll look at dietary changes, lifestyle adjustments, and support systems for weight loss. By improving blood sugar regulation and reducing inflammation, NAC supports fat loss and hormone balance. Supplementation can improve metabolic health and make weight loss easier. Low vitamin D levels are linked to obesity and insulin resistance. Studies show that better sleep hygiene can further benefit insulin sensitivity, hormone balance, and mood regulation. This sunshine vitamin can help reduce stress, which is great for insulin sensitivity, appetite regulation, and fat storage reduction! MetaMulti multivitamin is designed to fill nutrient gaps that drive PCOS problems like hair loss, cystic acne, fatigue, and weight gain. If you experience digestive issues, skin breakouts, or increased inflammation with whey, consider plant-based alternatives like pea, hemp, or rice protein. For most women with PCOS without pre-existing kidney disease, protein intake in the recommended range (1.2-1.6g/kg) is safe and beneficial. The ideal PCOS plate typically includes 25-30% protein, 40-45% non-starchy vegetables, 15-20% healthy fats, and 10-15% complex carbohydrates, though your specific needs may vary. If you follow a plant-based diet, you can still meet your protein needs with PCOS. Working with a registered dietitian who specializes in PCOS can help you determine your personalized protein targets. It has been found that low-fat hypocaloric diets can help reduce body weight and composition compared to high-fat hypocaloric diets. Testosterone levels in hyperandrogenic insulin-resistant women correlate with abnormal endothelial function. Additionally, it explores the potential benefits of dietary supplements and herbal remedies in PCOS management. It’s also helpful for wound healing and thyroid health, both of which can be impacted by PCOS. If you don’t eat fatty fish like salmon regularly, a high-quality fish oil supplement can be a game-changer. Omega-3s are anti-inflammatory powerhouses, and inflammation is a big part of the PCOS picture. There aren’t many studies that clearly show that vitamin D supplementation can promote weight loss. Since insulin resistance and chronic inflammation are prevalent in PCOS, a balanced diet and lifestyle changes can immensely improve your PCOS symptoms. The good news is, certain supplements can support metabolism, reduce cravings, and improve hormone balance when paired with a healthy lifestyle. The evidence suggests that, when combined with a balanced diet and lifestyle, these supplements can support metabolic and hormonal health. You don’t have to go it alone; the right support system and supplements may help your body’s natural metabolism and make weight loss more achievable. Managing weight can be mostly challenging for those with PCOS, as hormonal imbalances often lead to weight gain and difficulty losing weight. Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder affecting many women worldwide. For a detailed breakdown of supplements, check out our article on the best supplements for PCOS hair loss. It affects up to 18% of women of reproductive age and is characterized by hyperandrogenism, chronic anovulation, and irregular menstrual cycles. Polycystic ovarian syndrome (PCOS) is the most prevalent and extensively researched endocrine disorder affecting women of reproductive age. Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age, and presents a significant challenge to the global population. This helps support the site and keep our content free. Patients should seek out a multidisciplinary team, including a nutrition professional and a mental health professional. Additionally, collaboration with a team of healthcare professionals is so important for people with PCOS. Regular mindful yoga practice can be a useful complementary therapeutic option for people with PCOS, particularly for improving serum androgen levels. Additionally, it has been shown that zinc deficiencies are related to worsening symptoms. Polycystic Ovary Syndrome (PCOS) affects 6% to 18% of reproductive aged women in the United States. Women with PCOS often experience fatigue and low energy levels, which can be exacerbated by Vitamin B12 deficiency. If symptoms persist, seek a PCOS specialist. Track progress with body measurements, not just the scale. Pair with a low-GI diet rich in whole foods, 150 minutes of weekly exercise, and stress management. A PCOS support supplement containing chromium can improve insulin sensitivity in women with PCOS.A study of women with PCOS found that those who take metformin and liraglutide lose weight more quickly than with either drug alone.And as zinc supports overall thyroid health, it can be beneficial to take it on a daily basis.Supplements like inositol can also be super helpful here, as they can help regulate your mood and reduce anxiety.This is my favorite PCOS supplement for weight loss, because addressing insulin resistance is the number one priority if you want to lose weight with this disorder.Weight management apps make it easy to track what you eat, how much you exercise, and your weight changes.The best approach combines a nutrient-rich diet as the foundation with supplements to address specific deficiencies or challenges.Telehealth services have become an essential tool for crafting personalized nutrition plans to help manage PCOS. Taking it helps support weight loss in women with PCOS. Certain herbs and supplements support weight gain effectively when you have trouble or difficulty trying to shed off the extra pounds of unnecessary fat. Include foods in your PCOS diet that can reduce insulin resistance and inflammation. Of course, this is not an exhaustive list of supplements that can assist with weight loss. One study with a diet intervention reported double the number of ovulatory events in women without PCOS compared to women with PCOS, which was statistically significant (Table 3). Three intervention groups from two studies 31,38 measured body composition with computed tomography (CT). Five of the studies reported that the difference in weight post-intervention or the change in weight from baseline between the PCOS and non-PCOS groups was not statistically significantly different, whilst the remainder of studies did not report a p-value. One study with an anti-obesity drug intervention (Orlistat) + a hypocaloric diet + exercise intervention reported a statistically significant difference in total, LDL and HDL cholesterol post-intervention between groups, with women in the PCOS group having lower mean values (Table 5). Four intervention groups from three studies reported results for blood lipids 31,35,39. Eleven intervention groups from nine studies reported fasting insulin 30,31,33,35,38,39,40,44,46. Some supplements, like inositol, magnesium, omega-3s, and vitamin D, are safe and helpful for teens with PCOS symptoms. Stick with PCOS supplements that support metabolism and hormone balance without overstimulating your thyroid, such as inositol, magnesium, and omega-3s. If you’re not currently trying to conceive, the best supplements focus on balancing hormones, improving insulin sensitivity, and reducing inflammation. Some research also suggests berberine can improve cholesterol levels and support gut health, which is increasingly being linked to hormone balance. In women with PCOS, zinc supplementation may help reduce acne, support ovulation, and lower levels of unwanted hair growth caused by high androgens. Understand the interplay between PCOS, insulin resistance, and dietary choices. Berberine is an alkaloid extracted from herbs, known for its ability to improve insulin resistance. B vitamins, including B12 and folate, are essential for overall health and may be particularly helpful for women with PCOS. In this prospective trial, 100 women were divided to receive either metformin (500 mg three times daily) or NAC (600 mg three times daily) for 24 weeks. A study published in the European Journal of Obstetrics, Gynecology, and Reproductive Biology compared the effects of NAC and metformin in women with PCOS. Secondary messengers acts to repair the doorbell so that the cell doors open in response to glucose, resulting in less insulin needing to be secreted. This means that it takes longer for the cells to open its doors to glucose resulting in higher amounts of insulin needing to be secreted. Even if you eat these types of fish twice a week or more, you may consider taking a fish oil supplement. Boosting your B12 levels can improve your overall energy, helping you stick to a regular exercise routine, which is essential for weight loss. This vitamin not only aids in weight loss but also plays a crucial role in bone health, which is vital for maintaining an active lifestyle. Understanding how these vitamins work is crucial to effectively incorporating them into your diet and supplementation routine. Not only do they help manage some of the underlying symptoms, but they also support your overall well-being, making the weight loss process smoother and more sustainable. The field of PCOS supplementation continues to evolve, and ongoing research may reveal additional therapeutic options for supporting weight management in this challenging condition. While supplements can play a valuable supporting role, they should be integrated within a comprehensive treatment strategy that includes dietary modifications, regular physical activity, and appropriate medical supervision. A systematic review of 8 RCTs found that vitamin D supplementation, when combined with calcium, resulted in improved BMI and waist circumference measurements (Pergialiotis et al., 2017). The growing interest in PCOS supplements for weight loss reflects the urgent need for evidence-based interventions that can complement conventional treatments. Reach out to our PCOS dietitian today to receive personalised and evidence based support for your PCOS requirements and weight loss. Since up to 80% of those with PCOS also have insulin resistance, inositol needs may be higher in PCOS. Besides weight loss, you likely have other health-related goals, whether it be improving your mental health, reversing hair loss, or getting pregnant. In order to successfully lose weight, a healthy PCOS diet and lifestyle modifications are essential. This type of weight gain is commonly related to hormone levels. My goal is to help you navigate your health and reduce your PCOS symptoms using realistic and simple diet and lifestyle changes. Nine studies were designed with the specific aim of weight loss 34,37,38,39,41,42,43,45,46, while the remaining five studies did not state if the aim was weight loss 30,31,33,40,44. The aim of this systematic review is thus to assess the effect of lifestyle (dietary and non-dietary) weight management interventions on anthropometric, reproductive and metabolic outcomes in women with PCOS, compared to women without PCOS. This may be related to the hormonal aberrations of PCOS such as hyperandrogenemia or IR, contributing to abnormalities in energy homeostasis and dietary intake including gut hormone regulation 25,26, or an altered metabolism due to reduced postprandial thermogenesis . You can definitely get most of them from food, but if your doctor or Registered Dietitian determines you’re not getting enough through diet, you may want to use a supplement to make sure your bases are covered. An effective way to manage PCOS symptoms can be through changing your diet. It’s characterized by a range of symptoms, including irregular periods, ovarian cysts, excessive hair growth, acne, and weight gain. As the name suggests, PCOS may involve the presence of small, fluid-filled cysts on the ovaries, though not all women with PCOS have visible cysts. PCOS can present a wide range of symptoms, which vary in severity from person to person. Moreover, chronic low-grade inflammation is another contributing factor to PCOS. The management of this condition often includes a focus on diet and lifestyle changes. While there is no direct connection to improved fertility, folic acid has been linked to lowering BMI among PCOS patients, favoring an improvement in fertility outcomes when supplemented with inositol. At your next visit be sure to inform your healthcare consultant if you are planning to get pregnant, as you will be started on a supplementation of folic acid as well. Among the PCOS supplements regularly prescribed, inositol tops the list of its benefits to your fertility. Most collagen supplements come in hydrolyzed form (also known as collagen peptides), which are broken down for better absorption. While promising, more research is needed to determine ideal dosing and duration of supplementation for fertility-related benefits. Coenzyme Q10 (CoQ10) is one of the lesser-known – but increasingly researched – supplements for PCOS. Connect with a Health Loft dietitian for tailored support today.For women who are trying to conceive, it's particularly important to discuss supplements with a healthcare provider, as some may be helpful for PCOS and fertility while others might not be appropriate during pregnancy.A low frequency of gonadoliberin pulses results in the secretion of follicle-stimulating hormone (FSH), while a high frequency results in the secretion of luteinizing hormone (LH) from the anterior lobe of the pituitary gland.Always consult with your healthcare provider before starting any new supplement regimen, especially if you have other medical conditions or are taking medications.Inositol is a type of sugar alcohol and a vital part of cell membranes, playing a role in insulin signal transduction.Women with PCOS often have low levels of certain minerals, especially magnesium, which can exacerbate insulin resistance.Most women with PCOS need to take supplements consistently for 2-3 months before noticing significant improvements in weight management. Inositol is completely safe and has been found in studies to be very important to insulin signaling. However, women with PCOS who get these surgeries will need to be on a carefully controlled diet for the rest of their lives. Both of these surgeries result in a smaller stomach that cannot hold as much food, which usually leads to weight loss. Talk to your health care provider before beginning any restrictive diet. They are a good option for some women, especially those that cannot lose weight with other means and are not planning a pregnancy in the near future. Existing studies up to 12 months suggest acceptable safety when dosed appropriately, but ongoing monitoring for liver enzymes, renal function, and lipid profiles is prudent.In cases of infertility, overweight is common among PCOS-affected women.This is why improving insulin sensitivity is a key focus of supplements for PCOS weight loss.When the body becomes resistant to insulin, the pancreas produces more of this hormone, which stimulates the ovaries to produce more androgens.Depending on your dosage needs, I recommend either Integrative Therapeutics 500mg or Thorne 1000mg for berberine supplementation.Try to focus on whole grains, lean proteins, healthy fats, and fiber-rich foods, as these help regulate insulin levels and reduce cravings.One study also showed that HIIT also reduced excess testosterone levels, which can improve overall PCOS symptoms.Vitamin E is a potent antioxidant that can help reduce oxidative stress, which is often elevated in women with PCOS.Research consistently shows that how we nourish ourselves—rather than how much we weigh—can positively influence hormone balance, cycle regularity, and energy levels. Next, let’s explore the best vitamins to support metabolism, hormones, and sustainable fat loss. If you have PCOS, you’ve probably been told to “eat less and move more.” But when your hormones are out of sync, weight loss isn’t that simple. Let’s dive into the top five vitamins that can help women with PCOS lose weight naturally—and how to use them effectively. Certain nutrients play a key role in managing PCOS symptoms and making weight loss more achievable. Endurance training has been shown to reduce IR and improve metabolic profiles in overweight PCOS women.Some birth control pills have weight gain as a side effect, but many don’t.Data from 26 studies showed that supplementation with inositols in women with PCOS resulted in more regular menstrual cycles, and reduced testosterone, glucose, insulin, and BMI.Since insulin resistance and chronic inflammation are prevalent in PCOS, a balanced diet and lifestyle changes can immensely improve your PCOS symptoms.Metformin is not recommended as a first-line therapy for cutaneous symptoms, ovulation induction, prevention of pregnancy complications, or treatment of obesity.Other studies have shown that losing as little as 5-10% of weight results in resumption of menses and decrease in blood androgen levels.B12 and folate (B9) are the two forms of B vitamins for PCOS patients.By following these recommendations, you can take control of your health and support your body in managing PCOS symptoms more effectively.Research links optimal vitamin D levels with better body composition, while calcium deficiency is a common issue among women with PCOS. Supplements that improve insulin sensitivity such as inositol and magnesium are among the best fat burning supplements for PCOS. Adding supplements for PCOS can provide targeted support, filling nutritional gaps and helping your body respond better to diet and exercise. Women with PCOS often face higher levels of insulin resistance, inflammation, and hormonal imbalances. Many women ask about PCOS weight loss supplements that work and whether natural options can really help. Some women report earlier benefits like reduced cravings or improved energy within the first few weeks, but measurable weight changes typically require patience and consistency. Supplements work by gradually addressing underlying metabolic issues like insulin resistance and inflammation, which takes time. Many women benefit from a strategic combination of supplements rather than a single magic bullet. When combined with these lifestyle factors, targeted supplementation can help you overcome the metabolic challenges of PCOS and move toward your health goals. Studies are showing that women with PCOS have low levels of zinc. Many symptoms of anxiety such as apathy, anxious behavior, anger, nervousness, insomnia, rapid pulse, or heart palpitations may be reduced by supplementing with magnesium. Magnesium can also help prevent migraines and improve PMS symptoms as well as mood. This is concerning as magnesium has been shown to play a role in glucose, insulin, and blood pressure regulation. Elevated insulin levels or insulin resistance, which may underlie PCOS (1). For best results, combine optimal protein consumption with key nutrients like zinc, vitamin D, and omega-3 fatty acids that work synergistically to support hair health. By focusing on high-quality protein sources for PCOS and strategic timing, you can help balance your hormones, stabilize your energy, and support your body's natural healing processes. Many women with PCOS find that strategic protein timing helps reduce cravings and manage symptoms like fatigue and mood swings that can result from blood sugar fluctuations. The best protein sources for PCOS provide quality amino acids while supporting hormone balance and insulin sensitivity. Omega-3 fatty acids, found in fish, nuts, and avocados, also help with managing your insulin resistance. Abdominal obesity, or fat accumulation around the waist, increases the risk of cardiovascular diseases, making it crucial to address not only weight management but also overall metabolic health. With the vast array of PCOS supplements available, it can be slightly overwhelming to choose the right ones for you. Angela regularly provides nutrition education to registered dietitians and health care professionals through her Online PCOS Training Course for Dietitians and workshops. As always, please consult with your doctor before taking any dietary supplement. Ultimately, you’ll want to target the root cause of why you’re gaining weight in the first place. It may not happen immediately, but usually if weight comes off quickly, it goes back on quickly…which obviously isn’t what you want! Unfortunately, there’s no magic fix to lose weight fast with PCOS though. If you’re feeling depressed about your weight, I want to reassure you that it is possible to lose weight with PCOS. However, strict caloric restrictions do not produce the expected long-term effects 53,54, and the isocaloric diet did not significantly improve the biochemical and anthropometric parameters even in combination with physical activity . The growth of Bifidobacteria correlates with insulin secretion and increased glucose tolerance, regulates IR, and helps reduce inflammation. The microbiota, through its metabolites, has multiple and complex effects on appetite, lipids, and carbohydrate metabolism and may influence body weight 44,45. Women with PCOS with normal and low levels of androgens measured by the level of testosterone and free androgen index (FAI) were more susceptible to the development of oxidative stress and inflammation induced by TNF-α . Lipid-stimulated oxidative stress may be a key driver of insulin resistance and hyperandrogenism in PCOS. For short term use, most research studies used 500 to 1500 mg daily. Additionally, more research is needed but berberine may beneficially impact gut health. This supplement has become more mainstream in the past several months thanks to it being coined “Nature’s Ozempic”. Another reason I really like inositol is that it’s safe to take long term, including during pregnancy and while breastfeeding. Many women with PCOS report improvements in hair thickness and reduced shedding after optimizing their protein intake. Focus on diverse protein sources including plant-based options, fatty fish, and ethically raised animal proteins for the best hormone-supporting effects. Understanding your body's unique protein needs with PCOS is a powerful step toward managing your symptoms naturally. If you're managing PCOS and insulin resistance, you may need to aim for the higher end of this range.