Thanks to the keto diet, both men and women who struggled with being overweight for many years have achieved their dream figures. The ketogenic diet will allow you to achieve these goals! You can also confirm that your body has transitioned into ketosis using ketone tests. Hidden carbs found in many processed foods, sauces, dressings, or even some vegetables can quickly exceed your daily net carb limit and knock you out of ketosis, which will slow down or prevent fat loss. Subsequently, the contribution of amino acids is reduced, whereas the amount of glucose obtained from glycerol increases. In the first few days of the KD, glycogenesis from amino acids is the main source of glucose. Thus, reducing dietary carbohydrates and proper cholesterol intake will lead to the inhibition of cholesterol biosynthesis. Β-Hydroxy β-methylglutaryl-CoA reductase, a key enzyme in cholesterol biosynthesis, is activated by insulin. This approach not only helps clients achieve their immediate physical transformation goals but also empowers them with the knowledge and habits needed to maintain their health and wellness independently. This involves a holistic approach, incorporating custom fitness training, personalized nutrition plans, and consistent coaching support to help clients reshape their bodies and improve overall health. A body transformation coach like Julie Lohre specializes in guiding women through comprehensive lifestyle changes to achieve significant physical transformations. As with any diet, there are potential risks and side effects to consider when following the ketogenic diet.Whether you’re in a weight loss plateau or you’re simply looking to help shed a few pounds and feel healthier, keto could be exactly what you need.Many people report joint pain reduction and better gut health after switching to keto.The shift from diet thinking to this is just how I eat now makes all the difference for lasting success.Restricting carbohydrate consumption reduces the body’s availability of glucose, prompting a metabolic shift to fat-burning, a state known as ketosis.Caution should be exercised when prescribing the KD to T2DM patients on other drug treatments, such as sodium glucose cotransporter 2 (SGLT2) inhibitors and insulin.It’s not just about the number on the scale—keto often trims inches off your waist and boosts overall body composition by helping you maintain lean muscle mass.In the presence of oxygen, most cellular energy originates, through glycolysis, from glucose-metabolized pyruvate, which then undergoes oxidative phosphorylation within mitochondria. Don’t throw out all the habits you developed during keto. Either option keeps keto vibes strong without feeling overwhelmingly strict. Keto makes that fat feel unwelcome faster than you can say, “Goodbye muffin top.” Consistency is your BFF for keto success. With increased focus and mental sharpness, she excelled in her professional life and gained a sense of empowerment that she had never experienced before. She no longer felt constrained by insecurities and began embracing her body with newfound appreciation. Inspired by his own success, Joe now shares his story to motivate others to embark on their own transformative journey. Undergo a keto metamorphosis and regain your energy and enjoyment of life! Each is proof that with the right motivation and support, anyone can achieve their health goals and undergo a successful keto makeover. Read amazing stories from our community and join the keto movement, change your life, reach your goals and stay healthy. Do you dream of losing weight, having an attractive figure, feeling good and having more energy every day? Nutritional ketosis reduces hunger by up to 60% while targeting belly fat. Intermittent fasting can speed up ketosis when combined with your low-carb living approach. Weight loss journey continued steadily as my body adapted to using fat for fuel. This simple metabolic shift created ripple effects across my entire health. I detailed his keto dietary practices in an earlier article. At the same time, recent studies have questioned the health benefits of very low, as well as very high, carbohydrate diets. As a dietitian, my patients ask about a wide variety of diets. Then, once I reached that 6 month body transformation and I lost 40 lbs, finding the focus again to continue with the journey can be a struggle. I could lose weight and gain muscle for a total body transformation with a lifestyle that was maintainable for the long run. Part 4: Addressing Potential Challenges and Maintaining Long-Term Success Watch the video below to learn what to expect when starting a keto weight loss journey. This advanced version of the ketogenic diet emphasizes nutrient-rich, high-quality foods, including non-GMO organic vegetables, grass-fed beef, full-fat organic dairy, pasture-raised eggs, and wild-caught fish. This explains why the keto diet is highly effective in reducing body fat, as confirmed by research published in Canadian Family Physician.1 Ketosis benefits explain why these changes last so long for most people. Before and after photos show amazing body transformation results that speak louder than words. Carbohydrate restriction causes your body to flush water and minerals. Your body needs extra fluids to help with the transition. Glycogen depletion happens completely within 2-4 days, forcing your body to find new fuel sources. Body transformation happens as your metabolism changes to prefer fat as fuel. Health optimization happens gradually as your body makes these important changes. Carbohydrate restriction affects everyone differently based on your previous eating habits. This in turn inhibits the transcription of mitochondrial ribosome-encoding genes and mitochondrial biogenesis, leading to cardiomyocyte apoptosis and cardiac fibrosis.264 This study highlighted the unknown detrimental effects of the KD. Mechanistically, the KD increases levels of β-HB, promotes histone acetylation of the Sirt7 promoter, and activates Sirt7 transcription. In rat models, KD decreased mitochondrial biogenesis, reduced cell respiration, and increased cardiomyocyte apoptosis and cardiac fibrosis. Although the beneficial effects of β-HB on HF have been acknowledged by numerous reports, its safety on other cardiovascular problems has been challenged by certain lines of evidence. A clinical trial showed that positron emission tomography revealed an average decrease of 21.8% in glucose uptake at the tumor site in children after 8 weeks of KD implementation. Weight loss journey stories show that personal goals work better than copying someone else's plan. Ketogenic lifestyle success depends on your body's unique response to carbohydrate restriction. Sustained energy lasted throughout my day without crashes. Mental clarity became my favorite benefit of ketone production. If you stick to the diet and continue to intermittent fasting, you may be able to maintain this weight loss or even lose more over time. By the fourth week, you may notice significant improvements in weight loss, energy levels, and overall health. In the starting point of our journey, we delve into the fundamentals of the keto diet and intermittent fasting. Due to the decrease of blood glucose level during the implementation of the ketogenic diet, the glycolysis pathway in the brain is significantly inhibited, and the energy supplier of the central nervous system changes from glucose to ketone bodies. In a transgenic mouse model of AD, the KD reduced the level of soluble Aβ deposits in the brain by 25% after only 40 days.175 In addition, treatment with the KD, exogenous β-HB, and MCT reduced brain Aβ levels and improved cognitive ability.176 When a mouse model of AD was fed a KD for 43 days, serum levels of the KB β-HB increased, total Aβ levels decreased, mitochondrial function improved, and oxidative stress decreased compared to controls.177 Aged dogs receiving MCT showed dramatically improved mitochondrial function and decreased oxidative damage compared to age-matched controls.178 In aged rats, the KD improved cognitive performance due to increased angiogenesis and capillary density, supporting the theory that diet-induced ketosis is beneficial in the treatment of neurodegenerative conditions.179 Lack of physical activity Along with the weight gain came severe water retention in my feet and hair loss.While fat is a key component of the ketogenic diet, consuming too much can prevent weight loss, especially if calorie intake exceeds your body’s energy requirements.This water loss may cause dehydration and temporary electrolyte imbalances, which can contribute to keto-flu symptoms such as Intermittent fasting fatigue, headaches, muscle cramps, and dizziness.We will address the common misconception of a “slow metabolism” and how to optimize metabolic function.The LCDs, especially those with high-fat content, are reported to have a worsening effect on hepatic steatosis due to the influence on cholesterol levels and hepatic function.The hardest part my 6 month body transformation was keeping a positive outlook on those weeks that “something” came up. As your body burns fat and your cells become efficient at using ketones as an energy source, you’ll start to experience consistent fat loss, with weight reduction becoming more steady and gradual. “Staying hydrated and replenishing lost electrolytes is crucial to mitigating these typically mild and transient side effects and helping your body adjust to the ketogenic diet,” explains Dr. Berg. This approach enhances fat burning and promotes effective weight management by supporting ketosis and improving metabolic efficiency. This can significantly enhance fat burning as your body has to rely on stored body fat as a primary energy source during fasting periods. Most people experience significant weight loss within the first two weeks of keto. In addition to weight loss, there are various other signs that your body is in fat-burning mode. Lack of physical activity can hinder weight loss on keto by reducing calorie expenditure and slowing fat metabolism. Following Healthy Keto and practicing intermittent or prolonged fasting methods, such as the occasional 24-hour fast, is an excellent strategy to promote metabolic balance and long-term weight loss support. Powell continues to share her weight loss journey to her 256k followers on Instagram. This mom of two lost over 80 pounds on the keto diet and shares daily meals and inspiration on Instagram. Even if you’re not thinking of adopting the keto diet to drop excess pounds, these stories will provide the inspiration you need to put down the pint of ice cream and whip your diet into shape. Many people report losing 60 pounds or more over the course of a year on keto, which indicates an average weight loss of around five pounds per month. The authors of this study concluded, “Evidence suggests that a ketogenic diet can help with weight loss, visceral adiposity, and appetite control.” It’s essential to review your fat and carbohydrate intake to overcome stalled body weight reduction and continue weight loss on keto. Individuals often see marked improvements in metabolic health, including more stable blood sugar levels and reduced insulin resistance, as well as improved mental clarity and more energy. As energy levels stabilize and appetite decreases, adhering to keto becomes more manageable, supporting ongoing weight loss. Reaching ketosis isn’t the finish line—it’s more like buying a ticket to the carnival 🎡. Unlike calorie-counting diets, keto’s success relies on precise macronutrient ratios. When your body prioritizes fat over glycogen, the efficiency of fat-burning improves substantially. Incredible Keto Diet Transformations As your body becomes more efficient at utilizing fat for fuel, you might notice improvements in energy levels and mental clarity. As the body becomes more efficient at burning fat for fuel, you can expect a steadier rate of weight loss. The first week of combining keto and intermittent fasting may present some challenges as the body adapts to a new routine. By setting realistic goals and forming a structured plan, you are well-equipped to embark successfully on your keto and intermittent fasting journey. Dropping below 200lbs was a huge accomplishment for me because I never thought that I would ever get back to a healthy weight. In October I reached my 100lb weight loss mark. You can see more of her keto journey on Instagram. I know everyone will have different breaking points or reasons for making healthier lifestyle choices but this is the best way I can explain how I managed to get the motivation to give the #ketolife a shot and lose 114lbs.. After being on the diet for six months, this Aussie lost some serious weight and has never felt better. The KD is a biochemical model of fasting or starvation, which promotes the utilization of KBs as the dominant fuel source to replace glucose in the central nervous system.158 This may modulate the neuropathological and biochemical changes observed in AD, and the KD can directly reduce the accumulation of amyloid plaques while reversing Aβ toxicity; furthermore, KBs may protect against Aβ neurotoxicity.159 Kashiwaya et al. treated cultured rat hippocampal cells with Aβ, β-HB, or both Aβ plus β-HB. The polycystic ovarian syndrome (PCOS) is closely related to other metabolic and endocrinological abnormalities, including insulin resistance, hyperinsulinemia, T2DM, dyslipidemia, and hyperandrogenism, and is characterized by insulin resistance, androgen excess, and abnormal gonadotropin dynamics. The LCDs, especially those with high-fat content, are reported to have a worsening effect on hepatic steatosis due to the influence on cholesterol levels and hepatic function. We'll explain the situations in which professional guidance is beneficial and provide resources for finding qualified healthcare professionals. This section will discuss when it's appropriate to seek professional help from a doctor or registered dietitian. We’ll explore techniques like mindfulness and positive self-talk to foster a healthy mindset. This section will provide guidance on creating a balanced exercise regimen that includes cardiovascular exercise, strength training, and flexibility exercises. This section will guide readers in setting achievable goals, considering individual factors such as starting weight, fitness level, and lifestyle. Sources She clearly understands the unique needs of a woman’s body (especially those of us over 40!) and really held me accountable through the whole process. The exercise and diet plans she created for me were well thought out and really personalized specifically for me and my goals, but the best part of working with Julie Lohre is the support. I never went a day “hangry” which was a total relief coming off calorie deprivation from past body building shows. If you stick to the diet and continue to intermittent fasting, you may be able to lose even more weight over time. This weight loss is typically due to a combination of restricted caloric intake and ketosis-induced water loss. Again, the amount of weight you can lose in one month with keto and intermittent fasting will depend on your individual circumstances. A recent study found that intermittent fasting lowers the number of monocytes in the blood, which is a type of cell that causes inflammation.Perhaps my greatest challenge was eating while traveling.Balanced macros are your best friend here, and keto delivers.At the start of his ketogenic lifestyle, Joe weighed 250 pounds and had various health issues such as high blood pressure and elevated cholesterol levels.Thankfully I was rewarded with a 1kg weight loss!You can’t see or feel inflammation, so you may not notice any changes in your body.On average, you’ll lose about 1-2 pounds per week, but weeks of no change are still normal.In this review, we summarize the experimental and/or clinical evidence of the efficacy and safety of the KD in different diseases, and discuss the possible mechanisms of action based on recent advances in understanding the influence of the KD at the cellular and molecular levels. On average, you’ll lose about 1-2 pounds per week, but weeks of no change are still normal. To maximize results, pairing keto with strength training is a power move. Balanced macros are your best friend here, and keto delivers. The secret is in the diet’s design. Keto isn’t just about torching fat—it’s also about flexing your muscle game. Excitation of the steroid pathway enhances the synthesis and transmission of GABA at the synapse, while decreasing the content of aspartic acid and the excitability of neurons.229,230 It is suggested in several studies that the progeny of mice exposed to KD during pregnancy show lower susceptibility to anxiety and depression and significantly improve social and physical activity levels compared to the standard diet group. Moreover, KD treatment increases polyunsaturated fatty acids and induces the expression of neuronal uncoupling proteins, regulates numerous energy metabolism genes, and induces mitochondrial biogenesis, which further limits ROS generation and increases energy production.215 An increase in anti-peroxidase in the hippocampus protects the central nervous system from degenerative changes.13,189 Other studies showed that the KD exerted anti-inflammatory effects by decreasing the levels of pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α, in the substantial nigra.190 Cheng et al. found that β-HB could inhibit the apoptosis of dopaminergic cells that were exposed to MPTP in relation to the upregulation of Bcl-2/Bax mRNA.191 A summary of the KD-induced changes in PD is shown in Fig. It has been discussed that the injury of the respiratory chain and the mutations of mitochondrial DNA found in patients with PD suggest the importance of oxidative stress in PD.187 The accumulation of hydroxyl radicals in the brain may lead to increased dopamine metabolism and, at the same time, to the accumulation of iron in the redox form of neurons.188 KBs produced by liver metabolism not only promote mitochondrial respiration by increasing ATP production, but also reduce free radical production by increasing the efficiency of the mitochondrial respiratory chain complex (increasing NADH oxidation and inhibiting mitochondrial permeability conversion). Dispelling Common Myths About the Ketogenic Diet For example, β-HB increases the histone acetylation of genes that encode resistance factors against oxidative stress;145 (3) activates GPR109A, which is widely expressed in various types of immune cells and exerts anti-inflammatory effects in many diseases, including obesity, inflammatory bowel disease, and cancer;109,146 (4) inhibits NLRP3,147 a key inflammasome that activates pro-inflammatory cytokines, such as IL-1β and IL-18, which closely correlate with obesity and T2DM pathogenesis.148 Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent disease that is characterized by hepatic adiposity, which comprises fatty liver, fibrosis, and inflammation. The KD is obviously effective in the weight control of obese individuals; however, the underlying mechanism is incompletely understood. The majority of studies amply demonstrate that reduced carbohydrate uptake can decrease total cholesterol and TG levels and increase the HDL-C level.116,118 Furthermore, KD increase the size and volume of LDL-C particles59 which could alleviate the risk of cardiovascular disease that is attributable to the higher atherogenicity of smaller LDL particles. However, several lines of evidence support the positive effects of the KD on these cardiovascular risk factors. These accounts will highlight various strategies employed, including dietary changes, exercise routines, and mental fortitude. Some people may see results from keto and intermittent fasting within a few days, while others may take a few weeks to see any changes. However, many people have reported losing significant amounts of weight within the first few weeks of starting the keto diet. The amount of weight you can lose in a month with keto and intermittent fasting will depend on your individual circumstances. By May 2022, after a year of struggling with unexplained weight gain, I decided to follow Dr. Berg’s advice and combine keto with intermittent fasting. One of his videos, “6 Things That Make You Look Younger,” introduced the concept that keto and intermittent fasting together might be the only effective way to diet. Chris and April McIntosh had struggled with weight and dieting most of their lives, but with the help of keto and the support of each other, they were able to lose a combined 250 pounds. #myketotransformation #ketoweightloss #weightloss #weightlossjourney #ketofam #weightlossmotivation #fitfam #keto #ketodiet #ketotransformations After going keto, though, she dropped 336 pounds, now weighing a third of her former body weight. A well-planned keto diet can help achieve significant weight loss and enhance metabolic health, which promotes sustainable long-term weight management. Here’s a complete keto weight loss timeline, including signs of ketosis and typical weight loss patterns, so you know what to expect when embarking on a high-fat diet. (Some experts advise against the ketogenic diet for weight loss.) Keto and intermittent fasting are two ketogenic diet approaches that have been gaining traction in recent years. However, many people have reported losing anywhere from five to ten pounds in the first month of keto and intermittent fasting. KD has been reported to exhibit preventative effects on depressive-like behaviors in rodents while its exact mechanism is still unknown. Nagpal et al. find that the KD alters the gut microbiome signature and short-chain fatty acid in association with cerebrospinal fluid AD biomarkers.223 Moreover, KD is full of other nutrition such as ω-3s, tryptophan, vitamin B, which may regulate the disorders in both physiology and psychology.222 The gut–brain axis suggests that the microbiome plays an important role in mental health and an existing study proves that the KD may affect mental health through the gut–brain axis by the gut microbiome. In final, the KD can generate beneficial substances to reduce the happening of epilepsy.212,213 Under KD conditions, the reduction of brain glucose utilization and glycolytic ATP production may induce potassium channels that are sensitive to ATP opening, which leads to the hyperpolarization of the neuronal membrane,214 consequently reducing the electrical excitability of the brain and increasing the seizure threshold. Low-carb diet results can definitely last when people treat this eating style as a health turnaround rather than a quick fix. Jessie's photos reveal an amazing 50-pound weight loss through simple ketogenic lifestyle changes. Before and after photos capture real keto success stories that inspire many people to start their own body transformation journey. Fat metabolism becomes your body's main energy source as your liver turns fatty acids into ketones. Given that the composition of the gut microbiota varies in specific diseases, the possibility of disease-specific mechanisms of KD that are mediated through a functional axis that originates with gut microbes is worth exploring regarding the beneficial effects and side effects of the KD. As a metabolic therapy, the KD may function via a combination of multiple and complex mechanisms involving metabolic, cellular, and molecular responses. The mechanisms of action of the KD, especially at the cellular and molecular levels, in different types of diseases, are poorly understood. Upon DSS treatment, the KD-fed mice had decreased weight loss and disease activity index scores with reduced inflammatory cell infiltration in the intestinal epithelium. A recent study found that the KD can alleviate colitis in a dextran sulfate sodium mouse model compared with a low-carbohydrate diet and normal diet.20 A 16-week KD intervention before colitis induction in mice was found to increase the abundance of Akkermansia and Roseburia and simultaneously alter the gut metabolites. The KD increases levels of β-HB, promotes histone acetylation of the Sirt7 promoter and activates Sirt7 transcription in cardiac fibrosis and increases the availability of non-glucose substrates in cMPC1−/− hearts Again, the amount of weight you can lose in one month with keto and intermittent fasting will depend on your individual circumstances.The ketogenic diet will allow you to achieve these goals!For example, when there was stress at work, I would end up skipping lunch and then way overeating my dinner.In this blog post, we’ll dive into the world of keto and intermittent fasting, exploring the results one might expect after just 1 month.As the weeks turned into months, I continued to lose weight without feeling hungry or deprived.You may have discovered which fasting schedule works best for your lifestyle and preferences, and which keto-friendly foods and recipes you enjoy the most.By shedding excess weight, Joe reduced the strain on his cardiovascular system, leading to improved blood pressure and cholesterol levels. However, it’s essential to remember that initial weight loss might be primarily water weight, as glycogen stores are depleted. Selecting an appropriate intermittent fasting schedule is essential for optimizing results and maintaining consistency. Determining a realistic and achievable weight loss goal for the month is crucial for success. As part of this strategic approach, accessing a custom keto diet plan becomes an essential step. This metabolic state, known as ketosis, has been linked to a variety of health benefits. “As you burn body fat during the fasted hours, you lose weight, and fats are also a longer lasting and slower burning source of energy too. But intermittent fasting can actually increase your energy levels and boost your mood. Unlike crash diets, this weight loss tends to stick because keto focuses on fat loss rather than muscle loss. When people hear about the ketogenic diet, one of the first questions they ask is, “How much weight can I lose—and how fast? By cutting down on carbs and eating more fats, they have lost weight, gained energy, and improved their health. New muscles were popping up and the weight that I was able to lift steadily increased. I had more energy than every and my body was really getting tighter and leaner. I talked with Julie and she developed individualize training and nutrition plans to help me begin to add muscle as I lost bodyfat. I lost muscle, my energy took a nose dive, and I started packing on weight, especially in my stomach. There was a period where I tried intermittent fasting, but I found that I felt light headed in the periods where you are not supposed to eat and famished during the feeding windows. Please supply the information of interest or potential utility you find on these website pages to your healthcare practitioner to be evaluated within the context of your individual health conditions and circumstances. Reviewing a reliable keto food list can help you avoid these hidden sources and make smarter food choices. After a couple of months, steady fat loss at a rate of around one pound per week continues as your metabolism will have fully adapted to burning fat. This group of organic acids serve as a highly effective alternative fuel source when glucose is limited. The semaglutide formulation that is approved specifically for weight loss is called Wegovy. There are different formulations of semaglutide available for weight loss, each with its own brand name and dosing regimen. Ozempic, on the other hand, is the brand name for the semaglutide formulation approved for the treatment of type 2 diabetes, but it may also have weight loss benefits for some individuals.Other brand names for semaglutide include Rybelsus, which is a tablet formulation of semaglutide used for the treatment of type 2 diabetes. It is administered as a subcutaneous injection once a week and works in a similar way to Wegovy to help control appetite and promote weight loss. It is administered as a subcutaneous injection once a week and is typically used in conjunction with a reduced-calorie diet and increased physical activity. They showcase the power of shifting your body into a fat-burning state and the profound impact it can have on health, energy, and confidence. The keto adaption/fat adaption can take weeks, so it’s important to really stick with it for a while to teach your body how to be a fat burner instead of a sugar (glucose) burner. The average weight loss is pounds in the first month of doing keto. Sabrina is over 40 lbs now with her keto weight loss journey, getting closer and closer to her goal weight and mending her relationship with food. "I was carrying maybe 20 extra pounds, but my main issue was constant brain fog and energy crashes," he explained. Mark, a 35-year-old software developer, wasn't primarily focused on weight loss. "Low-fat, calorie counting, endless cardio... I'd lose a few pounds, then gain it all back, plus extra. I was constantly tired, my joints ached, and I just felt 'blah'." The only US FDA-approved pharmacological therapy is riluzole, which could prolong survival by ~2 months in ALS patients.199 Both groups showed significantly decreased MDS-Unified Parkinson’s Disease Rating Scale scores, but the KD group showed a greater decrease in Part 1 (−4.58 ± 2.17 points; 41% improvement in baseline Part 1 scores) compared to the low-fat group (−0.99 ± 3.63 points; 11% improvement) (P 196 In a rat model of PD, the KD, via glutathione activity, protected dopaminergic neurons of the substantia nigra against 6-hydroxydopamine neurotoxicity.192 In mice, β-HB infusion confers partial protection against MPTP-induced dopaminergic neurodegeneration and motor deficits.193 These effects appear to be mediated by a Complex II-dependent mechanism that improves mitochondrial respiration and ATP production. The knockout of α-Synuclein only increased the number of dopamine neurons which suggested that the loss of synucleins does not produce parkinsonism.185 In recent years, animal and in vitro studies have demonstrated the beneficial effect of KBs on the course of PD due to their function in mitochondrial homeostasis. Additional research is warranted to determine the therapeutic benefits of MCT in patients with AD and to ascertain how APOE-4 status may mediate β-HB efficacy. Before and after transformations on the ketogenic diet can be sustainable if the individual adopts a balanced and healthy approach. By restricting carbohydrates and entering a state of ketosis, the body starts burning stored fat for fuel. However, many people report seeing noticeable changes within the first few weeks of following a strict ketogenic diet. The ketogenic diet has gained popularity for its potential to help people achieve impressive transformations. First off, keto’s low-carb nature gives it a metabolic edge. It’s not just about the number on the scale—keto often trims inches off your waist and boosts overall body composition by helping you maintain lean muscle mass. Think of keto as your steady but reliable turtle in the weight-loss race. Sustainable weight loss takes time. The KD could increase the availability of non-glucose substrates in vivo and reverse the structural, metabolic, and functional remodeling of non-stressed cMPC1−/− hearts. Mice rendered incapable of oxidizing the ketone body 3-HB in the heart exhibits worsened heart failure compared with WT controls. The KD exerts a therapeutic effect on tumors such as neuroblastoma, acute myeloid leukemia, glioblastoma, etc., through decreased GPR109A expression, mTORC1 activation, and glucose uptake at the tumor site, which leads to decreased tumor growth, increased survival, and increased chemotherapeutic efficacy Similarly, Dai et al. reported that KD treatment decreased PD-L1 protein levels and increased the expression of type-I interferon (IFN) and antigen-presentation genes, leading to the enhanced efficacy of anti-CTLA-4 immunotherapy.249 The key molecular event of KD treatment in promoting immunotherapy is the activation of AMPK, which phosphorylates PD-L1, resulting in its disrupted interaction with CMTM4 and subsequent PD-L1 degradation, which phosphorylates EZH2, resulting in improper PRC2 function and subsequently enhanced expression of IFN and antigen-presentation gene.249 Due to a reduction in blood glucose levels, the KD could concurrently affect glucose metabolism and glucose-dependent signaling in tumor cells.236 Furthermore, glucose starvation leads to a suppressed lactate/pyruvate cycle, which inhibits neovascularization, hypoxia-induced vascular epidermal growth factor activation, and angiogenesis, and causes ultimate necrosis in tumor cells, especially for colon adenocarcinoma xenografts.237 KBs can inhibit inflammation, which is closely correlated with tumor pathogenesis. The expression of certain O-GlcNAc-modified proteins is altered when the KD improves hyperglycemia.104 Fatty acid synthase and acetyl-CoA carboxylase 1, which are two key enzymes that are involved in hepatic lipogenesis, are present in regular diet fed-ob/ob mice but absent in the KD-fed mice.105 KD administration decreased liver mRNA expression of Glucose transporter type 2 while increased that of Fibroblast growth factor 21 in diabetic mice.106 Glucose transporter type 2 plays an important role in glucose induced-insulin secretion in pancreatic β cells107 thus decreased Glucose transporter type 2 expression suggests a decreased insulin level and improved insulin resistance in T2DM.Health markers typically improve across the board when nutritional ketosis becomes your normal way of eating.Recently, nutritional therapies such as ketogenic diets are considered promising due to their effectiveness in preventing relapse."More importantly, my energy returned. I started hiking again, something I hadn't felt up to in years. Keto gave me back my vitality."So if you want to keep your body in top shape and prevent serious health problems down the line, intermittent fasting may be worth looking into.That’s because IF prolongs your body’s fatty acid oxidation stage, more commonly known as the fat-burning stage.”However, with proper planning, variety in food choices, and the availability of countless keto-friendly recipes, the diet can be both enjoyable and sustainable. Shortening your eating window revs up your metabolism and makes it easier to cut calories. And although you would think skipping meals would make you grumpy, once you adjust to going without food for longer periods, you’ll get a significant mood and energy boost. But if you can overcome them, you’ll experience a number of health benefits from skipping breakfast. Protein moderation keeps you from making too much glucose in your body. Avocados, olive oil, grass-fed butter, and nuts give you quality fats that help make ketones. Ketogenic lifestyle helps your body burn fat instead of sugar. Blood meters work better than breath or urine tests for tracking mental clarity and sustained energy levels. Sugar elimination benefits happen even when weight loss slows. On a keto diet, you keep insulin levels lower. On a 2,000-calorie-per-day ketogenic diet, this equates to about 100 calories (25 grams) of carbohydrates, 400 calories (100 grams) of protein, and 1,500 calories (167 grams) of dietary fat. A typical keto eating plan aims for about five percent of calories from carbohydrates, twenty percent from protein, and seventy-five percent from dietary fats. I also found ketogenic recipe books to be very helpful. Finally, I read about the bad breath often accompanied with ketosis. Instead, keeping my protein under control proved to be the greatest threat to knocking me out of ketosis. Before I started the diet, I thought my greatest challenge would be getting the recommended amount of fat, while taking in so little carbs. A quick check of my urine using my ketone at-home stick kit revealed I was on my way down the ketosis highway and I was euphoric. Therefore, reducing insulin levels should be a therapeutic target in the treatment of T2DM. More importantly, the blood glucose level of the VLCKD group was ~1 mM lower than that of the low-calorie diet group and reverted to a normal level after 24 weeks. A, b The KD increases the levels of FA and KBs and decreases plasma glucose concentrations through different pathways. In the presence of oxygen, most cellular energy originates, through glycolysis, from glucose-metabolized pyruvate, which then undergoes oxidative phosphorylation within mitochondria. Functional Medicine Before starting treatment with semaglutide, it’s essential to consult with a healthcare provider to determine if it is a suitable option and to discuss potential risks and benefits.As mentioned earlier, Wegovy is the brand name for the semaglutide formulation approved specifically for weight loss. It’s important to note that semaglutide for weight loss is intended for individuals who have a body mass index (BMI) of 30 or higher, or a BMI of 27 or higher with at least one weight-related comorbidity, such as high blood pressure or type 2 diabetes. While not specifically approved for weight loss, some healthcare providers may prescribe Ozempic off-label for this purpose. Ozempic is approved for the treatment of type 2 diabetes but has also been shown to promote weight loss in some people. Sugar is an inflammatory food and on a keto diet, you keep your sugar and overall carbohydrate intake very low. It can also lower inflammation levels which can help people with chronic inflammation. When these and other hormones stay in balance on a keto diet, you’re less likely to have hunger and cravings. Though, it can be hard to start a new diet so we got a whole list of keto before and after transformations and facts that are guaranteed to convince you to give the keto diet a try. It’s becoming such a popular diet that it’s common to see keto labels on food and when you search “keto” billions of responses will pop up. Metabolic health improvement happens naturally when insulin sensitivity increases through carb restriction. Weight loss journey starts with brave people who changed their lives through food choices. These amazing changes go beyond just losing pounds—they’re about getting healthy again. It had to be because my metabolism was sluggish and not cooperating after all of the highs and lows of playing with diet. I was curious to see how my dairy free experiment was affecting my weight, so after 2 weeks I caved in and weighed myself. 6 Month Weight Loss Transformation – Low Carb, Keto Diet Success – before and after pictures and video of losing weight with the Ketogenic Diet. It may not work for everyone but it’s worth trying if you’re looking to improve your health with a sustainable lifestyle change. My skin cleared up and hunger suppression made eating less feel natural. Energy levels soared while brain fog disappeared completely. Have you ever found yourself staring at a bag of pecans in the grocery store aisle, wondering, “Are these keto-friendly,... Every tweak, every hiccup teaches you something valuable about your own unique keto rhythm. Lastly, slipping up doesn’t mean throwing in the keto towel. After losing some serious weight on keto, Katelyn Falcone stresses to her Instagram followers not to focus as much on numbers on a scale; instead, count victories like feeling confident in your own skin. Here are 10 incredible weight-loss stories, all thanks to keto. If you need some motivation to try a new diet, check out these incredible keto transformations. Like Ozempic, Rybelsus may be prescribed off-label for weight loss in some cases. The mechanisms, through which the ketogenic diet ameliorates endocrine and metabolic disorders, including T2DM, obesity, NAFLD, and PCOS, are shown. T2DM is characterized by chronic hyperglycemia with fasting plasma glucose concentrations ≥126 mg/dL and glycated hemoglobin (HbA1c) ≥6.5%.90 As dietary carbohydrates are the major macronutrients that increase glycemic levels,91 it is logical to reduce the dietary carbohydrate intake to treat T2DM. In the potential physiological application of the ketogenic diet, some studies have found that KD could extend longevity and reduce midlife mortality in the mouse model.87,88 In fact, the mechanism of how KD works in our body from the intestine to the target site is still controversial. Therefore, increased blood glucose concentrations and higher insulin levels lead to increased endogenous cholesterol synthesis. Mark discovered that eating fat bombs satisfied his sweet tooth while staying in ketosis. Apart from preclinical studies, clinical trials have demonstrated the beneficial effects of the KD on antitumor therapy. Ferrere et al. found that anti-PD-1, alone or in combination with anti-CTLA-4, failed to inhibit tumor growth in mice receiving a standard diet, whereas KD implementation, or oral administration of 3-hydroxybutyrate (3-HB), a principal KB generated in the KD, reestablished therapeutic responses.248 3-HB prevented the upregulation of PD-L1 on myeloid cells whereas promoting the expansion of CXCR3+ T cells and instituting consequent T cell-mediated tumor immunosurveillance. Therefore, low levels of β-HB attenuate the tumor-suppressive function of GPR109A in colon cancer cells.239 Recent studies have extended the tumor-suppressive function of the receptor beyond the colon, as GPR109A suppressed mammary tumorigenesis in a mouse model of breast cancer.240 Cancer is one of the greatest global public health challenges and is a leading cause of global mortality. However, after several months of following the ketogenic diet, Sarah experienced a profound transformation, not only in her physical appearance but also in her mental well-being. Joe’s inspiring transformation serves as a testament to the power of the ketogenic diet to completely transform lives. By consuming healthy fats and minimizing carbohydrates, Joe was able to break free from the constant cravings and energy crashes that plagued him in the past. Before we delve into the inspiring before and after transformations, let’s first understand the benefits of the ketogenic diet that make these transformations possible. Step into the lives of individuals who have taken charge of their health and witnessed remarkable changes in their bodies, energy levels, and overall well-being. Let these keto diet success stories inspire you to start, or continue, your own transformation. Embarking on a keto journey can feel daunting, but knowing others have walked the path – facing similar struggles and ultimately succeeding – can make all the difference. Rather than letting it go to waste, our body will store it as fat. So, hang in there—your keto journey is far from over. On the flip side, overloading on even keto-friendly fats can stall progress. Instead, aim for moderate activity that aligns with your energy levels during the adaptation phase. 🎉 But let’s talk about an often overlooked companion to your keto journey—physical activity. Some hit ketosis in 2 days, while others (especially carb lovers) might take a week or more. You can lose 20 pounds within four to five months of following a nutritious low-carb diet such as Healthy Keto®. These tests, available as urine strips, breath analyzers, or blood meters, measure the presence of ketones in your body. This helps keep you fuller for longer, stabilizes your blood sugar and insulin levels, and reduces cravings between meals. To curb snacking, consume adequate amounts of healthy fats with your meals. However, be mindful of portion sizes, avoid extra fat sources such as fat bombs, and understand your macronutrient needs using a keto calculator. Your journey might look different, but the potential for positive change is real. "More importantly, my energy returned. I started hiking again, something I hadn't felt up to in years. Keto gave me back my vitality." "I didn't want to deal with the 'keto flu,' so I made sure to salt my food well and took a magnesium supplement." She was hesitant about keto, worried it was too extreme. "Weight just kept creeping on, especially around my middle, no matter how 'healthy' I tried to eat," she said. Therefore, the treatment goal is to improve insulin resistance and weight loss and decrease luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratios and excess androgen levels (Fig. 3). A small clinical trial revealed a greater reduction in intrahepatic TGs in patients with NAFLD after a 2-week carbohydrate-restricted diet without calorie restriction than in patients who received a calorie-restricted diet, without any significant weight-loss differences in the two treatment groups.140 Consistently, a 2-year multicenter trial that included more than 300 patients who enrolled in a comprehensive lifestyle modification regimen demonstrated similar weight-loss patterns with low-fat diets and LCDs, although the LCD group displayed superior HDL-C profiles.141 Besides fat and weight loss, the KD can exert a series of other beneficial effects on obesity. The expression of certain O-GlcNAc-modified proteins is altered when the KD improves hyperglycemia.104 Fatty acid synthase and acetyl-CoA carboxylase 1, which are two key enzymes that are involved in hepatic lipogenesis, are present in regular diet fed-ob/ob mice but absent in the KD-fed mice.105 KD administration decreased liver mRNA expression of Glucose transporter type 2 while increased that of Fibroblast growth factor 21 in diabetic mice.106 Glucose transporter type 2 plays an important role in glucose induced-insulin secretion in pancreatic β cells107 thus decreased Glucose transporter type 2 expression suggests a decreased insulin level and improved insulin resistance in T2DM. Despite the adverse effects described, the KD usually does not have long-term tolerability, which not just introduces barriers to compliance by caregivers and patients but also compromises the clinical efficacy of the therapy.New muscles were popping up and the weight that I was able to lift steadily increased.Protein moderation keeps you from making too much glucose in your body.With the disorder of intestinal microflora, the barrier function of the intestinal epithelium is gradually reduced or even lost with the increased permeability, which then mediates the enhancement of immune response and causes chronic neuritis.Your precise weight loss timeline can vary based on factors such as your starting weight, previous diet or lifestyle habits, metabolic flexibility, and how well you adhere to a low-carb diet.Join the weight loss journey with community support #fok #pcos #insulinresistance #weightloss When keto and intermittent fasting are combined, they can work synergistically to promote weight loss and improve overall health. The researchers compared the ketogenic diet in mice with the obesity-inducing high-fat diet and found that the ketogenic diet, while apparently healthier, significantly reduced glucose tolerance. On one hand, due to its low-carbohydrate content, the KD could decrease insulin levels, with a consequent increase in fat oxidation and reduced lipogenesis,143 and induce a microbiome shift, with increased folate production and limited inflammatory and oxidative stress.54 On the other hand, the KD-induced KBs may result in (1) satiety, which limits food intake and facilitates weight loss;144 and (2) epigenetic modifications, which play an important role in NAFLD pathogenesis. SGLT2 inhibitors, which confer cardiovascular benefits in T2DM patients, can also exert pro-ketogenic effects by mediating a metabolic switch from glucose to lipid utilization. While fat is a key component of the ketogenic diet, consuming too much can prevent weight loss, especially if calorie intake exceeds your body’s energy requirements. The keto diet helps the body become more efficient at burning fat for fuel, while intermittent fasting promotes the use of stored fat for energy during the fasting periods . The keto diet can lead to weight loss, improved mental clarity, increased energy levels, and better blood sugar control, among other benefits . Ketogenic diets exert therapeutic effects on metabolic disorders through various mechanisms, including reduction of plasma glucose, glycated hemoglobin levels, and serum insulin levels; improvement of insulin sensitivity; increased satiety; and decreased inflammation However, while some individuals may experience greater weight loss, others may see more modest results, depending on how well they adhere to a low-carb diet, their metabolic health, and their general activity levels.However, weight loss plateaus are common during this stage, often linked to consuming too many calories as the body requires less energy after significant weight loss.If you stick to the diet and continue to intermittent fasting, you may be able to lose even more weight over time.Most people find their energy stabilizes by the end of the first week.Following Healthy Keto and practicing intermittent or prolonged fasting methods, such as the occasional 24-hour fast, is an excellent strategy to promote metabolic balance and long-term weight loss support. But after a few weeks, your inflammation levels will likely decrease and continue to improve the longer you follow the diet. A recent study found that intermittent fasting lowers the number of monocytes in the blood, which is a type of cell that causes inflammation. Research has also shown that intermittent fasting reduces inflammation. “Intermittent fasting could decrease several markers of inflammation and may be useful in treating inflammatory conditions, such as multiple sclerosis.” However, with proper planning, variety in food choices, and the availability of countless keto-friendly recipes, the diet can be both enjoyable and sustainable. Drinking an adequate amount of water helps to prevent the dreaded “keto flu” and supports overall health. By shedding excess weight, Joe reduced the strain on his cardiovascular system, leading to improved blood pressure and cholesterol levels. My brain worked better using ketone bodies for energy instead of sugar. My body began fat-burning mode after glycogen depletion emptied my stored carbs. Ketogenic lifestyle started my transformation with quick water weight loss. By October 5th, after an 18-day prolonged fast, I reached my goal weight of 65 kg (143 lbs). Even though I wasn’t on any medications or diagnosed with health conditions, I started feeling healthier overall. As the weeks turned into months, I continued to lose weight without feeling hungry or deprived. As with any diet, there are potential risks and side effects to consider when following the ketogenic diet. Furthermore, the ketogenic diet can be beneficial for those seeking to maintain a stable energy level throughout the day or improve their cognitive function. Instead of solely focusing on strict ketosis, individuals can incorporate a more flexible approach, such as a cyclic or targeted ketogenic diet. For example, expression of β-hydroxybutyrate dehydrogenase 1 (a key enzyme in the ketone oxidation pathway) and ketogenic β-hydroxybutyryl-CoA, in association with increased myocardial utilization of β-hydroxybutyrate, is increased in the heart failure samples supported the notion that the hypertrophied and failing heart shifts to ketone bodies as an alternate fuel and myocardial ketone oxidation as a key metabolic adaptation in the failing human heart.258,259 In mice and canine pacing model of progressive heart failure, increased delivery of 3-HB ameliorates pathologic cardiac remodeling and dysfunction.Furthermore, the KD is a multidisciplinary therapy that requires the involvement of experienced caregivers, such as doctors, nurses, and dietitians, in addition to the patients.284 Thus, successful implementation of the KD requires well-organized and consistently functioning cooperation between caregivers and patients, and clinical settings that support this cooperation.However, many people report seeing noticeable changes within the first few weeks of following a strict ketogenic diet.I also noticed my food cravings and water retention returned during strawberry season–most likely from eating too many berries.Regularly reevaluate your goals and adjust your keto diet and intermittent fasting schedule as necessary to ensure continued progress.This study demonstrated that a high-fat ketogenic diet led to more sustained weight loss and a significantly lower body fat percentage than a low-fat diet, underscoring its effectiveness in managing body weight. April lost 150 pounds, and Chris lost 100. I appreciate this new body so much. We gained a dog and lost 230 pounds. His top tips are to make sure you have keto-friendly snacks handy at home and to drink plenty of water. While weight loss is a common goal on the ketogenic diet, it can also help with body composition changes, such as reducing body fat percentage and increasing muscle mass. The ketogenic diet is a high-fat, moderate-protein, and low-carbohydrate eating plan that shifts the body into a state of ketosis. This study demonstrated that a high-fat ketogenic diet led to more sustained weight loss and a significantly lower body fat percentage than a low-fat diet, underscoring its effectiveness in managing body weight. But a year after starting the ketogenic diet, I found that my body does not need to be in a constant state of ketosis for better health. This applies to most of the excess fat we eat from keto-friendly foods as well. Many of the foods included in a keto diet encourage collagen production, which is the protein that forms the structure of your skin that is there to keep it firm and wrinkle-free. When you combine that approach with whole, unprocessed foods, you lower inflammation levels which in return can help you lose weight and prevent life-threatening diseases. Longterm adherence studies show impressive staying power for keto followers. Coleen's dramatic weight reduction photos show her impressive 55-pound drop that completely changed how she looks and feels. Weight loss journey photos show results words simply can't explain. Body recomposition happens naturally as your metabolism shifts to fat-adapted metabolism. Metabolic flexibility develops because your body needs an alternative fuel source. In this review, we summarize the experimental and/or clinical evidence of the efficacy and safety of the KD in different diseases, and discuss the possible mechanisms of action based on recent advances in understanding the influence of the KD at the cellular and molecular levels. The KD has long been established as a remarkably successful dietary approach for the treatment of intractable epilepsy and has increasingly garnered research attention rapidly in the past decade, subject to emerging evidence of the promising therapeutic potential of the KD for various diseases, besides epilepsy, from obesity to malignancies. Mark, a 62-year-old with knee problems, returned to playing tennis after six weeks on keto. Lowcarb diet results come faster when you increase water intake and electrolytes during the first two weeks. By having keto-friendly foods readily available, you’ll minimize the chances of making unhealthy choices and maximize the likelihood of sticking to the diet. Before starting the ketogenic diet, it’s essential to educate yourself on its principles, food choices, and potential challenges. The ketogenic diet plays a crucial role in these inspiring before and after transformations. The ketogenic diet acted as a catalyst for her personal development, allowing her to break free from self-limiting beliefs and embrace a more fulfilling life. We'll also discuss the importance of macronutrient balance (carbohydrates, proteins, and fats) and the impact of micronutrients on overall health and weight management. My experiment was a great example of something I say to my patients every single day — there is no “one size fits all” diet out there. Studies show that high protein diets (especially when rich in red and processed meats) have also been linked to increased mortality. An August study in the Journal Lancet questioned the health benefits of very low, as well as very high, carbohydrate diets, citing an increase in mortality for both. By the second week, you might find it easier to adapt to your new eating schedule. You can experiment with different fasting windows and adjust as needed. However, this may vary depending on individual factors such as age, gender, starting weight, and activity level. The amount of time it takes to see results will depend on your individual body type, metabolism, and how strict you are with the diet. However, remember to consult your healthcare provider before making any significant dietary or lifestyle changes. Remember that maintaining a healthy lifestyle is a lifelong journey, and the lessons learned during this month can serve as a strong foundation for continued success. You might see a significant reduction in body fat and an improvement in muscle tone. People everywhere are dropping serious weight and keeping it off with keto. Quality food selection determines how well your body burns fat. This simple step helps your body stay in fat-burning mode all week long. Nutritional ketosis works best when you cook meals ahead on weekends. Meal prepping saves time and helps you avoid food choices that might kick you out of ketosis. In your first month of intermittent fasting, you may shed a few pounds without having to count calories. Intermittent fasting is a diet that involves fasting for most of the day and eating within a limited window. In spontaneously hypertensive rats, the KD increases hypertension,279,280 impairs endothelium-dependent relaxation in mesenteric arteries,280 causes renal damage279 and aggravates interstitial fibrosis and inflammatory responses in the heart.281 In the rat, The KD exacerbated disorders of glucose and lipid metabolisms and activated the renin-angiotensin-aldosterone system,279 and the ketone body might reduce eNOS expression via NF-κB singling pathway in vein endothelial cells,280 which could collectively contribute to hypertension and endothelial dysfunction. Many keto dieters report an average monthly weight loss of around five pounds. Incorporating regular exercises, including strength training and cardio workouts, enhances metabolic health and accelerates fat burning, thereby supporting weight loss. Snacking and grazing, even on keto-friendly foods, can lead to excess calorie intake and trigger frequent insulin spikes, which can slow down fat-burning and, consequently, weight loss. Jessie shed 50 pounds while Coleen dropped 55 pounds through high-fat nutrition. Her 80-pound weight loss has stayed off for five years through careful meal planning and occasional carb cycling. Nutritional ketosis helped Lisa Baker achieve long-lasting success too. I finally feel like myself again, Coleen explains, thanking her fat-adapted metabolism for giving her energy all day long. Highfat nutrition provides steady energy while appetite control makes sticking to the plan easier. Smart dietary shift followers use many tools to track their true health changes. Most people find their energy stabilizes by the end of the first week. Ketone bodies start replacing glucose as your main energy source during this critical time.