Kat highlights the medication's effectiveness in reducing appetite, which contributed to her substantial weight loss. Penny, a 50-year-old, shares that she has "not had any side effects and has lost around 70 lbs" while using Mounjaro for 6 months to 1 year. Impressively, she has maintained her weight loss for a year using a maintenance dose of 5 mg once a month. She lost 25 lbs in just one month by combining the medication with healthy eating. Changes appear gradually over several weeks as the body processes the treated fat cells. Edenfield’s experiences have been so overwhelmingly positive that at the end of our call, I felt the need to ask if he thinks there are any downsides at all to weight-loss injections.She estimates that at least 200 people have messaged her directly to ask about her experience.The medication may be prescribed as part of a medically supervised weight loss programme for eligible individuals who meet specific criteria.And often, stopping them leads to weight regain,” says Dr. Ravi Sankar Erukulapati.However, no significant statistics were found between tirzepatide and GLP-1 RAs (5mg and 10 mg) or between tirzepatide (10mg and 15 mg) and basal insulin.When the findings from this study were first released in a preprint last year, Novo Nordisk told CNN that it wasn’t a fair comparison.Side effects including nausea, diarrhea and constipation were reported more frequently in people taking the drug than those taking the placebo. The evidence supporting Mounjaro for weight management continues to grow stronger. The medication provides ongoing support for weight maintenance, which is often the most challenging aspect of weight management. The reduced hunger and cravings create space for developing healthier relationships with food. Many successful users report that Mounjaro makes it easier to adopt and maintain healthier eating patterns. This professional support helps maximise treatment success and addresses any concerns that arise. Uncommon and rare side effects include increased heart rate, increased gastric enzyme levels, pancreatitis, angioedema and anaphylactic reactions. Common side effects include nausea, headaches, stomach upsets (diarrhoea and vomiting) constipation, tiredness, acid reflux and indigestion symptoms, gallstones, dizziness, hair loss and reactions at injection sites. As your treatment progresses and your monthly dosage increases, the monthly price may also increase. Treatment prices will start from £169 £149 per month for your first order of Mounjaro; including your medication, at-home delivery and the supportive oversight of our clinical team. Some newer drugs also target GIP receptors, which may further support fat metabolism and energy use. But are these injectable drugs truly revolutionary, or just another short-lived wellness trend? JAS highly recommends Mounjaro to others seeking significant weight loss results. The significant reduction in constant thoughts about food has positively impacted her eating habits and weight loss journey. Sarah, a 55-year-old female weighing 183 lbs at 5’6, was "amazed how fast it started to work." In less than a month on the lowest dose of 2.5 mg, she lost 10 lbs in three weeks. Related Articles Ozempic is rumored to be used cosmetically by celebrities, causing it to be branded a “Hollywood drug.” Perkins, the family physician, says she has seen “a small fragment of people” who come to her wanting to use it to lose 10 pounds. Last summer, Massey approached Apollo outside of work to discuss starting on the drugs; the company asked her to record her journey and post about “the good and the bad” on TikTok, where she now has 4,800 followers. Sequence’s medical director, Spencer Nadolsky, has over 60,000 followers on his own personal TikTok page, where he discusses Sequence and semaglutide. Anyone claiming to use retatrutide outside a clinical trial cannot know for certain what they are taking.Compounded versions of weight-loss injections are also often easy to get without seeing a doctor in person.But what happens when a drug that can be transformative for the people who need it, ends up in the hands of someone that doesn't?Managing weight is no longer just about strict diets and intense workouts.Tirzepatide (LY , Mounjaro) is the first dual GIP and GLP-1 RAs for the treatment of T2DM, obesity, and nonalcoholic steatohepatitis .During your re-order consultation, we’ll ask you to update us on your progress and how you’re getting on with Mounjaro (including regular weight and side effect updates).Wegovy and Mounjaro became household names in 2022, alongside other relatively young drugs such as Ozempic, Victoza, and Saxenda.Approval isn’t expected before mid-2026, which is when the trials are expected to end.Sequence is one such weight-loss program that advertises on TikTok; the company prescribes FDA-approved, branded GLP-1 RAs, and videos hashtagged #JoinSequence have a combined 14 million views. “It just makes me feel really good that I can inspire people to do something better for themselves,” she says. She estimates that at least 200 people have messaged her directly to ask about her experience. Another semaglutide influencer is Kennedy Massey, a 25-year-old advertising professional from Nebraska whose agency creates advertisements for telemedicine provider Apollo Virtual Health. Rice first found out about the provider’s program through a promotional Facebook post; she signed up and began taking compounded semaglutide in May 2022. Seven more TRIUMPH trials are expected to complete throughout 2026. It is illegal in the UK to sell retatrutide for human use as the drug has not yet been approved. Anyone claiming to use retatrutide outside a clinical trial cannot know for certain what they are taking. These hormones work together to reduce hunger, slow digestion and increase the body’s use of stored fat. Before the Phase 3 data, a Phase 2 trial with 338 adults showed promising results at 48 weeks. On average, study participants weighed about 241 pounds (109.5 kilograms) to start and had a body-mass index — a common measure of obesity — of about 38. Sold as Mounjaro, it has been used “off-label” to treat obesity, joining a frenzy of demand for diabetes and weight-loss medications including Ozempic and Wegovy, made by Novo Nordisk. The injected drug, tirzepatide, was approved in the U.S. in May 2022 to treat diabetes. By comparison, a group of people who also dieted and exercised, but then received dummy shots, lost weight initially but then regained some, researchers reported Sunday in the journal Nature Medicine. Recent studies comparing different treatments in this category show promising results. The landmark SURMOUNT-1 trial, published in the New England Journal of Medicine, followed participants for 72 weeks and provided compelling evidence of the medication’s effectiveness. This comprehensive approach addresses multiple aspects of weight management simultaneously. Kick-Start Your Effortless Weight Loss Journey Are you ready to embark on a transformative weight loss journey? Mounjaro (tirzepatide) and Ozempic (semaglutide) are both prescription-only medicines... Two prescription medicines have gained attention in medical weight management circles. The Secret to Effortless Weight Loss Effortless weight loss might sound like a dream, but it's more achievable than you... For individuals who meet the medical criteria and can access treatment, Mounjaro represents one of the most effective options currently available. Furthermore, some studies found that meaningful weight loss is achieve 5 ~ 10% . After consuming tirzepatide, most of the patients experienced diarrhea, nausea, vomiting, decreased appetite, constipation, injection site reactions, and nasopharyngitis. Across all trials, the hypoglycemia risk of tirzepatide did not differ compared with placebo and GLP-1 RAs, and was lower with tirzepatide compared with basal insulin. In this study, there was no significant difference in the incidence of serious adverse events between tirzepatide and placebo, and basal insulin, but significant difference to GLP-1 RAs. Initially, the heterogeneities of three tirzepatide doses were observed to be high, but when we removed any one study, the heterogeneities in both groups did not decrease remarkably. Furthermore, another study showed that tirzepatide did not increase the risk of major cardiovascular events in participants with T2DM versus controls . Tirzepatide (LY , Mounjaro) is the first dual GIP and GLP-1 RAs for the treatment of T2DM, obesity, and nonalcoholic steatohepatitis . Moreover, it also contributed to weight loss by slowing gastric emptying. Across social media, influencers promote health-care services that provide compounded, non-branded formulations of these medications, something some obesity specialists have warned against. Each of these drugs is a GLP-1 receptor agonist (GLP-1 RA), meaning it mimics the hormone glucagon-like peptide 1, which is released after eating and causes a feeling of fullness. Wegovy and Mounjaro became household names in 2022, alongside other relatively young drugs such as Ozempic, Victoza, and Saxenda. (Pancreatitis is a known possible side effect of these drugs.) Fortunately, 20 additional trials 17, 44, 45 aiming to investigate the efficacy of tirzepatide in the clinical setting of T2DM or obesity are ongoing. Consistently, compared with placebo, GLP-1 RAs and insulin, more participants receiving any of the three tirzepatide doses had reductions in body weight of at least 5%, 10%, or 15% (Table 2). The body weight of patients was significantly decreased 1.93 kg (95% CI (-2.81, -1.05) when compared with insulin group. The body weight of patients was significantly reduced 1.05 kg (95% CI (-1.48, -0.63) when compared with GLP-1 RAs group. Searching results and study characteristics Subsequently, Novo Nordisk developed Wegovy specifically for weight loss. Though they both contain the same active ingredient, the drugs have different indications, dosages, prescribing information, titration schedules, and delivery devices. “This time last year I wasn’t having these conversations about these particular drugs,” she says. It’s not kilos lost in a month. Social media platforms are filled with influencers touting results, often without context, medical guidance, or long-term perspective. People with legitimate medical need are now facing shortages, while those looking to drop a few kilos for aesthetics may be playing with a fire they don’t fully understand. But health is not a destination. And often, stopping them leads to weight regain,” says Dr. Ravi Sankar Erukulapati. Our skilled clinicians are trained to tailor treatments to our wide range of clients. VIVO Body Studio is a leading UK-based group of aesthetic studios offering minimally invasive fat reduction and anti-ageing treatments. At VIVO Body Studio, we are dedicated to providing affordable, non-invasive aesthetic treatments that deliver noticeable and lasting results. Managing weight is no longer just about strict diets and intense workouts. Mounjaro weight loss represents a significant leap forward in medical weight management technology. Mounjaro contains tirzepatide, which stimulates both the GLP-1 and the GIP receptor – this combination has been shown to have greater weight loss potential than medicines that work on GLP-1 alone. They’re all designed to aid weight loss alongside a healthier diet & lifestyle changes (including regular exercise). These weight loss medications are approved for use by the MHRA, the UK government department responsible for ensuring that medicines and medical devices work and are acceptably safe. If you’re using another weight loss medication, such as Wegovy, you’ll need to wait up to 4 weeks before switching to Mounjaro. In addition, no significant difference in the incidence of SAEs between tirzepatide and placebo, and basal insulin, but significant difference to GLP-1 RAs.Concerns about weight loss drugs have been raised before.Related article Popular weight-loss and diabetes medications linked to lower risk of some cancers, study findsTake the first step towards weight loss that lasts.She wants to lose weight to be able to walk and ride a bike freely again without pain.Your treatment will be supervised by our qualified pharmacists and clinical team at all times.Rice first found out about the provider’s program through a promotional Facebook post; she signed up and began taking compounded semaglutide in May 2022. How easy is it to get weight loss drugs? Best for localised, pinchable fat in people near a healthy weight; it’s not a weight‑loss method. Dubai is fast emerging as a leading destination for advanced, non-surgical weight loss treatments. With appropriate professional support and commitment to complementary lifestyle changes, many people achieve meaningful, sustained weight loss that significantly improves their quality of life. If patients rely only on the injection, results plateau. That’s higher than the results for semaglutide and similar to the results seen with bariatric surgery, said Apovian. Those who received the dummy shots regained about 2.5% of their initial weight, or 6 pounds (2.7 kilograms). After three months of intensive diet and exercise, more than 200 participants left the trial, either because they failed to lose enough weight or for other reasons. Moreover, this study could have a higher effect on weight loss due to participants of the SURMOUNT-1 study not having T2DM and the SURPASS J-Combo study with only Japanese populations. A study found the incidence of gastrointestinal bleeding occurred most frequently 0 ~ 4 weeks after the first dose and was higher for the 15 mg tirzepatide group . Gastrointestinal side effects of high-dose GLP-1 RAs and co-agonists occurred in 30% ~ 70% of patients, mostly arising within the first 2 weeks of the first dose, being mild or moderate in severity, and transient . The results showed that tirzepatide could reduce the weight of T2DM and obese patients. At the same time, the network meta-analysis results of Alkhezi et al. also showed that compared with liragrutide and semaglutide, tirzepatide had better weight reduction in non-diabetes patients, and the safety results were similar without difference . In this study, we included 10 RCT (12 reports) and compared the weight loss effects of tirzepatide with placebo, insulin, and GLP-1 RAs. Based on our findings, both doses of tirzepatide were more effective in reducing bodyweight compared with other drugs. Its effect on body weight could make it useful as a weight loss drug. Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of obesity . Some researchers reckon that overweight and obesity are major risk factors for cardiovascular disease . In conclusion, tirzeptide can significantly reduce the weight of T2DM and patient with obesity, and it is a potential therapeutic regimen for weight-loss, but we need to be vigilant about its gastrointestinal reaction. But the risk of more serious adverse outcomes — such as bowel obstruction, gasteoparesis or pancreatitis — were found to be similar among those taking tirzepatide and semaglutide. Dosage can then increase every month as your treatment continues, with a maximum weekly dosage of 15mg. When you first start taking Mounjaro, the starting dose is 2.5mg once weekly for 4 weeks, increasing to 5mg once weekly for the following 4 weeks. The KwikPen comes pre-filled with 4 doses, lasting 4 weeks. Understanding Fat Freezing Benefits (Cryolipolysis) Cryolipolysis, commonly called fat freezing, represents a revolutionary FDA-approved approach to non-surgical body contouring. Losing weight is proving to be a challenge, especially when diet and exercise lifestyle modifications do not bear the desired... London's wellness industry continues to lead global innovations in aesthetic treatments, with breakthrough research from King's College London revealing that... In contrast, participants on a placebo (inactive treatment) lost just 3.2 kg. This combination not only lowers blood sugar but also reduces hunger, leading to weight loss. Experts note that many diabetes patients in India struggle with suboptimal glycaemic control (difficulty maintaining stable blood sugar levels), highlighting the need for newer therapies. Fig 2. Graphs of risk of bias for studies. Insanely beautiful and glossy people are telling me why I should or shouldn't take weight loss drugs.After three months of intensive diet and exercise, more than 200 participants left the trial, either because they failed to lose enough weight or for other reasons.A treatment bundle includes an 8-week supply (2 pens) instead of the standard 4-week supply.This treatment is only available after consultation with a qualified prescriber.With appropriate professional support and commitment to complementary lifestyle changes, many people achieve meaningful, sustained weight loss that significantly improves their quality of life.Among the breakthrough treatments capturing attention, mounjaro weight loss has emerged as one of the most promising options available.Throughout 2022, rising demand for weight-loss injections caused global shortages.It’s odd to be in an obesity trial and try not to lose any more weight.” Additionally, the gastrointestinal adverse events (including diarrhea, nausea, vomiting and decreased appetite) of tirzepatide were higher than those of placebo/basal insulin, but similar to GLP-1 RAs. In total, ten studies (12 reports) involving 9,873 patients were identified. The odds ratio (OR) was calculated using fixed-effects or random-effects models by Review Manager 5.3 software. Most people see better, more sustainable results when these medications are combined with improved nutrition, movement, and sleep, rather than relying on the drug alone. Experts recommend using GLP-1 drugs in combination with lifestyle changes, not as a replacement. For people already on the lower end of the weight spectrum — or those not engaging in resistance training — this muscle loss could do more harm than good. Several studies have found that up to 25–40% of the weight lost with GLP-1 medications can come from muscle, not fat. I didn't meet the BMI criteria, so I increased my weight on the form. Then it asked for some pictures to verify my weight. I filled in some personal details and my health history. Now, she has lost over eight stone and counting. After seeing celebrities using Ozempic, she went to her doctor and asked for the drug. Obesity specialists have spoken out against compounded semaglutide (which is often mixed with other ingredients, such as B vitamins) because the formulations haven’t always undergone testing and there’s little oversight in the industry. In the face of shortages, some people have turned to compounded versions of brand-name medicines. Out of pocket, Wegovy can cost up to $1,349 a month (a Novo Nordisk spokesperson says the company advocates for broadened insurance coverage of anti-obesity medications). Even with shortages ending, high costs mean some patients can’t afford official sources. The new study, which was funded by Eli Lilly, enrolled about 800 people who had obesity or were overweight with a weight-related health complication — but not diabetes. In phase two trials involving 338 obese participants, women on retatrutide lost an average of 28.5% of their body weight over 48 weeks, while men lost an average of 21.2%. To sum up, this meta-analysis indicated that tirzepatide could significantly decrease body weight in T2DM and obesity patients, and it is a potential therapeutic regimen for weight-loss, but we need to be vigilant about its gastrointestinal reaction. In our study, tirzepatide were more effective than other drugs in reducing bodyweight of 5%, 10%, or 15%. Advances in medical science have introduced treatments that... Why I Decided to Embark on a Weight Loss JourneyLike many people, I've struggled with my weight for years. Managing your social life whilst taking Mounjaro for weight loss can feel challenging, particularly when it comes to alcohol consumption.... This rapid onset of appetite control helps people establish new eating patterns more easily. No side effects that I have noticed other than loss of appetite and no cravings for sweets”. One patient reported losing over 2.5 stone in 5 months, with their weight dropping from 73kg to 60kg. These reviews provide valuable insights into real-world effectiveness beyond clinical trial settings. For people already on the lower end of the weight spectrum — or those not engaging in resistance training — this muscle loss could do more harm than good.“Novo Nordisk had estimated that the market would double after the launch of Rybelsus (oral semaglutide), but it actually grew 22 times, and the company is still working to meet supply,” she said.The odds ratio (OR) was calculated using fixed-effects or random-effects models by Review Manager 5.3 software.At VIVO Body Studio, we are dedicated to providing affordable, non-invasive aesthetic treatments that deliver noticeable and lasting results.Second, only one study focused on the obesity patients in all 10 RCTs (12 reports), and RCTs have generally carried out in selected populations of T2DM or obesity patients.It's not just celebrities and TikTok creators jumping on the weight loss drug hype."There is a lot of social pressure to look a certain way but your health is worth so much more," she said. The medication may be prescribed as part of a medical weight loss programme for eligible individuals following proper medical assessment. The combination of impressive clinical results, positive patient experiences, and professional medical oversight creates a compelling case for considering this treatment option. The appetite suppression effects help people naturally reduce portion sizes and resist unhealthy food cravings. Comparing the long-term costs of obesity-related health complications against treatment costs helps put the investment in perspective. In the SURMOUNT-1 study, adults with obesity or excess weight (without diabetes) who took Mounjaro 15 mg lost an average of 21.8 kg over 72 weeks, while those on the 5 mg dose lost 15.4 kg. What happened to body positivity, I wondered, as I typed 'How to buy weight loss drugs' into my phone. Insanely beautiful and glossy people are telling me why I should or shouldn't take weight loss drugs. In clinical trials, people started to lose weight within the first four weeks. That's more than one-quarter of total body weight on average, the highest seen in any obesity treatment trial to date. The most common side effects are gastrointestinal, including nausea, diarrhea, and constipation. The results may be enviable, but the day-to-day reality of weight-loss injections is not always pleasant. When his weight crept up to 357 pounds (he is 6 feet 3 inches tall), he sought gastric sleeve surgery because his employer would cover the cost. Is retatrutide available in the UK? Safer options now Sushi's journey showcases how Mounjaro can lead to rapid weight loss and long-term weight maintenance when coupled with a healthy lifestyle. The following table shows what can be achieved based on the 21.1% mean weight loss in the clinical trial. As an increasing amount of people turn to the drug and see great results its popularity is increasing and scaled production has made Mounjaro, with the active substance tirzepatide, widely available to the public. The Positive Outlook: Why Mounjaro Shows Real Promise This dual-action mechanism makes it effective for treating both type 2 diabetes and chronic obesity. It works by activating both GIP and GLP-1 receptors, helping lower blood sugar and support weight loss. Wegovy, a once-weekly glucagon-like peptide-1 (GLP-1) receptor agonist, has been approved for both long-term chronic obesity treatment and reducing the risk of major cardiovascular events. Since my prescription was approved Superdrug has introduced "enhanced assessments" and will require new patients to submit three date-verified photographs. I spoke to Superdrug and Simple Online Pharmacy and asked them why I was able to lie about my weight and be approved for Wegovy. At six months, average weight loss was 10% on tirzepatide and about 6% on semaglutide. But 82% of people taking tirzepatide reached this important clinical benchmark, compared with about 67% of those taking semaglutide. However, she cautioned that without lifestyle changes, people often regain lost weight—or even more—after discontinuing treatment. India has nearly 100 million adults living with obesity, a chronic disease that also raises the risk of over 200 health complications, including hypertension, dyslipidaemia, coronary heart disease, and obstructive sleep apnoea. Excess weight is linked to a higher risk of cardiovascular disease, hypertension, and metabolic disorders, making new treatments crucial. The overall weight management industry in India is currently worth about $25 billion and is expected to more than double to $56 billion by 2033. Obesity rates in India are rising, with the obese/overweight adult population projected to grow from 180 million in 2025 to 450 million by 2050, according to a report by Nuvama Institutional Equities. The drug boosts insulin production, improves insulin sensitivity, suppresses appetite, slows digestion, and reduces post-meal glucagon levels. Tirzepatide as the first dual GIP and GLP-1 RA drug, which shown effects on hypoglycemia, body weight and cardiovascular indicators in previous studies 31–33. In this paper, we performed a comprehensive systematic review and meta-analysis of all currently available randomized controlled trials (RCTs) of tirzepatide in individuals with T2DM and obesity to evaluate weight loss and adverse events when they were treated with tirzepatide. Tirzepatide also supported substantial weight loss in a recent clinical trial, potentially supporting its use as an obesity treatment . In sub-analysis, the body weight of patients was significantly reduced in three tirzepatide doses (5 mg, 10 mg, and 15 mg) when compared with those of the placebo/GLP-1 RA/insulin. Discontinuation was common — more than half of patients stopped their treatment before the end of the study — but rates were similar among those taking tirzepatide and those taking semaglutide. Along with side effects, people who did not lose weight while taking these medications may be more likely to stop or switch drugs, the researchers say. According to the new study, individuals with type 2 diabetes had less significant weight loss than those without a diagnosis — but average weight loss was still greater among those taking tirzepatide. For type 2 diabetes, the SURPASS clinical trial programme found that Mounjaro reduced A1C levels by up to 2.4% over 40 weeks, whether used alone or with commonly prescribed diabetes drugs like metformin and SGLT2 inhibitors. Additionally, one in three patients on the highest dose lost over 25% of their body weight. A significant loss body weight in the tirzepatide group versus the placebo by -9.81 kg (95% CI (-12.09, -7.52), GLP-1 RAs by -1.05 kg (95% CI (-1.48, -0.63), and insulin by -1.93 kg (95% CI (-2.81, -1.05), respectively.One 2021 study of 2,245 obese patients given GLP-1 RAs found that 2.2% developed acute pancreatitis; a history of type 2 diabetes, tobacco use, and chronic kidney disease increased the risk.Hall has decided she will seek the treatment elsewhere.Most people see better, more sustainable results when these medications are combined with improved nutrition, movement, and sleep, rather than relying on the drug alone.People on the highest dose lost nearly 29% of their body weight after 68 weeks.But are these injectable drugs truly revolutionary, or just another short-lived wellness trend?It’s important to note that when you stop Mounjaro, to maintain your weight longer-term, you need to adopt lifestyle changes and regular exercise. A company spokesperson adds that patients experiencing nausea on Wegovy “should contact their health-care provider, who can offer guidance on ways to manage it.” Here, people report experiencing vomiting, headaches, fatigue, “sulfur burps,” and hair loss—though the vast majority seem to feel it’s a small price to pay for losing weight. He lost 15 pounds in his first month on the drug and switched to Wegovy in February 2022. In June 2021, it became the first new treatment for chronic obesity approved by the FDA since 2014. Both the reviews and the trials show that Mounjaro helps people lose a significant amount of weight — often around 20% or more of their starting weight. JAS had a great experience with Mounjaro over 1 to 6 months, stating it "works great, definitely recommend for weight loss." They lost about 30 pounds in the first month alone, highlighting the medication's effectiveness. She shares, "Have lost 26 lbs in 15 weeks... I am loving Mounjaro. I’m so happy." While she occasionally struggled to eat because she didn't feel hungry, there were not many side effects. Mounjaro, which uses the active substance tirzepatide, was launched in India on March 20 following approval from the CDSCO. Danish pharmaceutical giant Novo Nordisk on Tuesday finally launched its blockbuster weight-loss injectable medication Wegovy in India. The overall weight management industry in India is currently worth about $25 billion and is expected to more than double to $56 billion by 2033 Obesity rates in India are rising, with the obese/overweight adult population projected to grow from 180 million in 2025 to 450 million by 2050. "There is a lot of social pressure to look a certain way but your health is worth so much more," she said. Now, patients come to her and specifically ask about Ozempic.Additionally, there was a statistically significant difference in the incidence of adverse events leading to study drug discontinuation between tirzepatide and placebo, between tirzepatide (15mg) and GLP-1 RAs, and between tirzepatide (5mg) and basal insulin.Meanwhile, Eli Lilly plans to finish clinical trials of Mounjaro for obesity by April.But this year the hot topic is "who's going on the pen?" - the weekly injection that is now widely used for weight loss.Once approved and dispensed, we’ll securely deliver your treatment using our free RoyalMail Tracked 24 option.It's designed for obese adults (with a BMI over 30) or overweight adults (with a BMI over 27) who have other weight-related medical problems. The reported weight loss and diabetes improvements are significant and could be life-changing for some. As a healthcare professional focused on nutrition and holistic wellness at Dr. Sumaiya NutriCare Clinic, I see Mounjaro as a potentially powerful tool for specific patients under careful medical supervision. Yes—many people experience nausea, GI upset, or other side effects, and there are more serious risks for some individuals, which is why medical supervision is essential. Appetite often increases again, and some weight regain is common if lifestyle changes and habits aren’t in place to support your new body weight. In one major study, participants regained two-thirds of lost weight within a year of discontinuation. The treatment became the newest GLP1 weight loss option available for mounjaro UK patients in February 2024, following massive success in the US, where it has been available since 2022. Nearly 29% of those taking the drug lost at least a quarter of their body weight, compared with just over 1% of those taking placebo. Overall, about 88% of those taking tirzepatide lost 5% or more of their body weight during the trial, compared with almost 17% of those taking placebo. If you take the drug without being prescribed it, the side effects can be brutal. A simple internet search revealed a raft of online pharmacies advertising the drugs, including Superdrug and Simple Online Pharmacy. But what happens when a drug that can be transformative for the people who need it, ends up in the hands of someone that doesn't? She was always an "active fat person", she explained, but "never considered weight loss before". Anyone on the Ascend Plus trial? Diabetes Discussions Hall has decided she will seek the treatment elsewhere. Absolutely I would try it again,” she says, three months after the side effects caused her so much pain. She wants to lose weight to be able to walk and ride a bike freely again without pain. Seeing success stories in the Facebook group made her feel “jealous, sad, mad, disappointed, lost, and fat.” (Patients typically start on 0.25 mg and if necessary can increase the dosage every four weeks until they reach a maintenance dose of 2.4 mg.) LeFebvre waited two months before she and her doctor agreed to try her on the next highest dose. Keep in mind, Mounjaro might not be suitable for you (even if you're using another weight loss medication). Your previous weight loss medication needs to fully leave your system during a 'washout' period. Different weight loss medications aren’t interchangeable. Consult a qualified professional to determine which option suits your specific needs and body type. Your clinician will also talk you through the details prior to your treatment. The specific risks are outlined on the treatment pages of this site. We offer a range of treatments which carry minimal risk, particularly when compared to surgical alternatives. The remaining balance is paid at the clinic on the day of your treatment. Discuss your individual health profile, the potential benefits FOR YOU, and the very real risks. The patent for tirzepatide is expected to expire around 2026. Crucially, Mounjaro should only be used under strict medical supervision. While the potential benefits are compelling, understanding the full picture, including the risks and costs, is crucial before considering this treatment. Sequence is one such weight-loss program that advertises on TikTok; the company prescribes FDA-approved, branded GLP-1 RAs, and videos hashtagged #JoinSequence have a combined 14 million views. While neither Novo Nordisk nor Eli Lilly pays influencers or online health-care providers to tout Wegovy or Mounjaro, a growing number of telehealth providers pay TikTok creators to promote their services. In the United States, online drug advertising is legal for on-label uses. Mounjaro is a revolutionary new once-weekly injectable weight loss medication that can help you lose weight. One of the more troubling trends is how quickly these drugs are being adopted outside their intended purpose. The U.S. Food and Drug Administration has granted the company a fast-track review of the drug to treat obesity, which Eli Lilly may sell under a different brand name. They were mostly mild to moderate and occurred primarily as the dose of the drug was escalated, the study found. The remaining nearly 600 people were randomized to receive tirzepatide or a placebo via weekly injections for about 16 months. In terms of safety, the incidence of any adverse events and adverse events leading to study drug discontinuation was higher in the tirzepatide group, but the incidence of serious adverse events and hypoglycaemia was lower. Tirzeptide is a novel glucagon-like peptide-1 receptor (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) drug, which shows good efficiency for weight loss. Related article Ozempic reduces risk of serious illness and death in people with diabetes and kidney disease, study finds Tirzepatide and semaglutide both mimic the effects of the gut hormone GLP-1, which stimulates the body’s production of insulin and slows the passage of food through the stomach. Many people find that successful weight management provides both immediate and long-term value. While Mounjaro represents a significant financial commitment, many people find the investment worthwhile given the potential health benefits and quality of life improvements. NHS availability remains limited, with strict eligibility criteria meaning many people who might benefit cannot access funded treatment. Currently, access through private healthcare providers offers the most straightforward route to treatment. It's not just celebrities and TikTok creators jumping on the weight loss drug hype. These are testing retatrutide for weight management and related health conditions like type 2 diabetes and sleep apnoea. In December 2025, the TRIUMPH-4 trial showed retatrutide delivered 28.7% average weight loss at 68 weeks, along with significant improvements in knee pain. In the phase 2 study, participants started to see measurable changes within four weeks of treatment. As both a Registered Dietitian and qualified physician, she specializes in holistic health management through integrated medical nutrition therapy. With over 16 years of experience and 80,000+ successful health transformations, Dr. Sumaiya combines medical expertise with nutritional science. Always consult with a qualified healthcare provider for any health concerns or before making any decisions related to your health or treatment. Considering Mounjaro or struggling with weight management or diabetes? Sustainable weight management and optimal health outcomes require a holistic approach. “This is a prescription drug for a reason,” says family physician Perkins. Novo Nordisk does not support or promote the use of our medicines outside of the FDA-approved indication, whether by telehealth providers or otherwise.” Apollo Virtual Health ships them directly to patients’ doors. Compounded versions of weight-loss injections are also often easy to get without seeing a doctor in person. All the drugs, which carry retail price tags of $900 a month or more, have been in shortage for months. NHS certified education, meal plans and coaching shown to support weight loss and improve HbA1c. Unusually, 100% of trial participants lost at least 5% of their weight. More obese participants saw an even greater percentage of weight loss, averaging 26.5% over the same period. With the increase of obese people, the drugs for obesity treatment has been on the rise, and most of the drugs currently used to treat obesity started out as treatments for diabetes . Based on our findings, both doses of tirzepatide (5 mg, 10 mg and 15 mg) were more effective than other drugs in reducing body weight. The findings from this study align with clinical trial results, but the study authors note that more research is needed to compare the effects that tirzepatide and semaglutide have on other key health outcomes, such as heart-related events. The FDA approved higher doses of both tirzepatide and semaglutide to treat weight loss, but the new study looked only at the doses to treat type 2 diabetes. People taking tirzepatide injections lost more weight and were more likely to reach specific weight loss targets than those taking semaglutide, according to a new study. As excitement around the drug continues to grow, researchers and medical experts stress the importance of ongoing studies to ensure its safety and long-term effects. However, the study, published in the New England Journal of Medicine, also highlighted its potential benefits beyond weight loss. Yet, some participants in clinical trials reported losing too much weight too rapidly. Unlike other weight loss jabs, this drug not only reduces appetite but also speeds up metabolism, intensifying fat loss. Second, only one study focused on the obesity patients in all 10 RCTs (12 reports), and RCTs have generally carried out in selected populations of T2DM or obesity patients. Unlike conventional diabetes and weight-loss drugs, Mounjaro works by enhancing insulin secretion, reducing glucagon production, slowing gastric emptying, and improving fat metabolism. Novo Nordisk says the prescription-only drug could significantly improve the quality of life for millions of Indians struggling with obesity or being overweight. It uses the active substance semaglutide, which mimics GLP-1 and targets areas of the brain involved in appetite regulation—helping reduce hunger, increase feelings of fullness, and ultimately support sustained weight loss. It’s important to note that when you stop Mounjaro, to maintain your weight longer-term, you need to adopt lifestyle changes and regular exercise. You have a BMI above 30 or have a BMI above 27 and a weight-related accompanying condition Mounjaro is designed as a long-term treatment and can be prescribed for up to 2 years. Ozempic and Wegovy, the brand names of a GLP-1 RA known as semaglutide, are both made by Novo Nordisk, a Danish pharmaceutical company. In 2005, the US Food and Drug Administration approved the first drug of this kind, Exenatide, for diabetics. GLP-1 RAs were first developed to treat type 2 diabetes; their hormone-mimicking action provokes insulin production. And can all the publicity lead people to do things they definitely shouldn’t do? What are the physical, social, and psychological side effects of a miracle? “Obesity and diabetes are serious conditions linked to various life-limiting health complications, making effective and sustained treatment critical. Lilly’s Mounjaro enters a growing weight-loss drug market in India, especially with the global success of GLP-1 receptor agonists like Novo Nordisk’s semaglutide (Wegovy, Ozempic). “The dual burden of obesity and type 2 diabetes is rapidly emerging as a major public health challenge in India. The drug has shown promising results in global clinical trials. This is contrary to the results of a study by Bhagavathula et al. the results shown that no significant difference the incidence of any adverse events . For the safety, a significant difference the incidence of any adverse events between tirzepatide group and placebo/GLP-1 RAs/basal insulin. Besides, there was no significant difference in the incidence of nasopharyngitis was noticed between tirzepatide and placebo, GLP-1 RAs, and basal insulin. When compared with placebo, the incidence of injection site reactions was lower in tirzepatide (5 mg and 10 mg), but no significant difference in tirzepatide (15 mg). Meanwhile, there were no statistically significant differences in the incidence of injection site reactions between tirzepatide and GLP-1 RAs, and basal insulin. Many create custom weight-loss programs to follow in addition to injecting the drugs. Some simply prescribe the drugs to patients while others send the drugs directly. LeFebvre, who is now 55 and a town clerk in New York, took a number of since-discontinued weight-loss drugs in the decades that followed. One 2021 study of 2,245 obese patients given GLP-1 RAs found that 2.2% developed acute pancreatitis; a history of type 2 diabetes, tobacco use, and chronic kidney disease increased the risk. Peter Kurtzhals, Novo Nordisk’s chief scientific advisor, says that such side effects normally decline gradually as patients build up a tolerance to the drug. Let’s break down what they are, how they work, and whether the hype around weight-loss injections is backed by real science — or misleading shortcuts. The analysed reviews are similar to the clinical trial results presented by Eli Lilly. "Now eating sensibly and have dropped a dress size in 5 weeks," she notes. She reports "zero negative side effects," which contributed to her positive experience. Therefore, we aim to investigate the efficacy and safety of tirzepatide for weight loss in type 2 diabetes mellitus (T2DM) and obesity patients in this meta-analysis study. After three months, people taking tirzepatide had lost about 6% of their body weight, on average, compared with an average of less than 4% loss among those taking semaglutide. The UK government is even proposing to use weight loss drugs to help tackle obesity and get people back to work. At the highest studied dose (12mg), participants lost an average of 28.7% of their body weight after 68 weeks in phase 3 trials. Studies have found, though, that one year after finishing treatment, semaglutide patients regain two-thirds of the weight they lost on the drug. When a drug takes over the internet, it of course takes over the world. The Incredible Shrinking Man and his sister are one family with two very different experiences of our current weight-loss injection boom. Edenfield’s success story is the most popular post on a Reddit forum dedicated to weight-loss injections. And some universities allow study sponsors to control the outcomes of research—something that is explicitly prohibited at Cal. Known as DIVCO, the body could be thought of as the executive arm of Berkeley’s academic senate.