The authors concluded that topiramate was effective in reducing binge eating behavior and weight. Topiramate was administered at a dose of 100 to 600mg/day depending on response to treatment. Search terms included “topiramate” and “binge,” “binge eating,” “obesity,” and “binge eating disorder.” The search in computerized bibliographic databases was complemented with journal hand-searching. BED is characterized by recurrent episodes of binge eating (defined as the ingestion of a large quantity of food in a discrete period of time) accompanied by a subjective sense of loss of control over eating. Binge eating disorder (BED) has been the subject of an increasing number of recent studies; nevertheless, it is still awaiting official diagnostic recognition, and it is classified as a syndrome in need of further study in the most recent edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). Fourteen of 30 patients in the topiramate group (46.7%) and 12 of 31 patients in the placebo group (38.7%) did not complete the 14 weeks of treatment. Topiramate might have a specific effect in reducing food intake mediated by its antagonism to glutamatergic transmission in the lateral hypothalamus.12 Other possible mechanisms of action reviewed by McElroy and colleagues13 include directly inducing weight loss by stimulating energy expenditure, decreasing binge eating by altering the rewarding properties of food, and reducing general impulsivity. Yes, Topamax is sometimes used off-label for weight loss, as it helps reduce appetite and food cravings. For those seeking effective weight loss treatment, Topamax can be a valuable tool in the fight against the obesity epidemic, but it must be used responsibly to ensure safe and lasting results. Baseline BMI percent of the 95th percentile (%BMI95), BMI (kg/m2), and weight (kg) were selected as those values recorded closest to the initial topiramate order. Mean doses at each time point were computed as the average over the entire course in those whose data went out to that point. In a recent study using EHR data from patients treated in our clinic, the prevalence of youth and/or caretakers on their behalf opting out of research was ~1% and was not meaningfully different by race/ethnicity (26). Participants included youth seen in the weight management clinic who did not opt out of having their EHR reviewed for the purposes of research via the Consent for Services form that all patients and/or caretakers complete. 5. Phentermine /Topiramate Is there any other advice I should follow while taking Topamax for weight loss? It typically takes 1-2 weeks for Topamax to begin working for weight loss. How long does it take for Topamax to start working for weight loss? Taking Topamax can help with weight loss, but it is important to follow your doctor’s instructions and monitor your progress to ensure the best possible results. Topiramate has numerous serious side effects that some people may find too severe to continue taking for treatment. Although some doctors may prescribe Topamax off-label to help someone lose weight, it's important to keep in mind that the drug can cause serious side effects. Because of its potentially severe side effects, Topamax should only be used as a last resort when other treatments have failed. Your doctor may prescribe Topamax (generic name topiramate) to help reduce food cravings and your appetite. If your weight is causing severe health problems, there may still be hope. The medication demonstrates effectiveness in reducing body weight across various dosages while also maintaining weight loss over time. In terms of weight loss, Topamax has been studied for its off-label use, and it is sometimes prescribed for obesity or binge-eating disorders. In addition to these primary uses, Topamax is sometimes prescribed off-label for conditions like bipolar disorder, post-traumatic stress disorder (PTSD), and even weight loss in combination with other medications. We conclude that, among youth with obesity prescribed topiramate plus lifestyle modification in a pediatric weight management clinical setting, mean percent change in %BMIp95 and BMI were both significantly reduced at 1.5, 3, 6, and 12 months after initiation, with %BMIp95 reductions from baseline of 2.2, 3.9, 6.6, and 9.3 percentage points at these time points. Overall, studies evaluating effects of topiramate on eating-related behaviors among youth followed in a pediatric weight management clinic are lacking. Which dosage of Topamax is ideal for weight loss? Although they are linked to more adverse effects, doses at the higher end of this range may cause greater weight reduction. Topamax dose recommendations for weight loss are nonexistent. Your healthcare practitioner may prescribe topiramate for additional conditions. When used for weight loss, the mechanism by which Topamax aids in weight reduction is not fully understood.Concurrent weight loss programs with nonpharmacological treatment were introduced to all patients.Drink extra fluids during your treatment with phentermine and topiramate.Treatment options for eating disorders typically involve a combination of approaches to address both the physical and psychological aspects of the condition.Although the evidence is preliminary, topiramate appears to be a relatively safe and effective treatment for obese subjects with BED. Doctors may change prescription medication dosages to help treat you safely and effectively. This article will detail basic facts about Rybelsus, including how it is used, how to take it, and possible side effects it may cause. This article will detail the various uses of semaglutide, how it works, its common side effects, and who it may be suitable for. The studies involving humans were approved by University of Minnesota Institutional Review Board. Finally, we were unable to reliably assess for side effects given that these were not captured in our EHR systematically and consistently. Further, the precision of our estimates may have been affected by secular trends in obesity interventions stemming from COVID-19. While many people focus on the dosage and frequency of topiramate, the time of day you take it can significantly impact its effectiveness. Always consult a qualified healthcare provider before initiating Topamax for weight management. Even though Topamax monotherapy is not formally approved for this use, many physicians prescribe it off-label based on its demonstrated effects in clinical studies and practice. Explore more options for a healthy and happy life Topiramate toxicity symptoms are similar to those of an overdose.Its effectiveness in reducing baseline weight and improving BMI has been proven in clinical trials, particularly when used alongside a reduced-calorie diet or ketogenic diet.Consulting with a doctor about Topamax for weight loss allows them to evaluate your overall health, discuss potential benefits and risks, and determine the appropriate dosage and treatment plan.Lost to follow-up, which has the potential to bias results in either direction and is an issue often more prevalent in observational studies compared to clinical trials, did increase over time, reaching 6.4% and 7.4% at the 6- and 12-month time points, respectively.Topamax’s influence on weight is thought to stem from its effects on appetite suppression, altered taste perception, and potential changes in metabolism.Finally, we were unable to reliably assess for side effects given that these were not captured in our EHR systematically and consistently. Carbidopa inhibits the peripheral conversion of 5-HTP to serotonin, attenuating the side effects and allowing 5-HTP to reach the CNS, where it will be converted to serotonin . Peripheral administration of GLP-1 in obese diabetic subjects demonstrated a reduction in food ingestion . Therefore, although this combination might become a novel promising tool of obesity pharmacotherapy, randomized controlled trials assessing this issue should be developed aiming a definitive answer. Treatment was single-blind for subjects receiving sc medication only and open-label for subjects in the combination arms. One patient in each group left due to adverse reactions at the site of injection and one patient in the combined treatment group abandoned due to nausea. What is the recommended dosage of Topiramate for weight loss? Taking too much topiramate can lead to serious side effects, such as kidney stones, increased risk of heatstroke, and cognitive impairment. This makes it an effective tool for people who struggle with overeating or have trouble controlling their food intake. With patience, dedication, and the right timing, you can unlock the full potential of topiramate and achieve a healthier, happier you. What is topiramate used for? The mean percentage change in weight and HgA1c from baseline to week 24 was assessed. Diet, exercise, and behavioral modification were adjusted, as well as maintaining the patients on a 600 kcal diet reduction based on their metabolic requirements. It was a multicenter, double-blind, placebo-controlled trial consisting of 646 obese men and women (aged 18–75 with a BMI of 27–50 kg/m2). Toplak et al. evaluated the safety and efficacy of TPM in obese patients with type 2 diabetes concurrently treated with metformin . It is important to note that this study first involved a 4-week meal replacement therapy run-in phase including shakes and pre-packaged frozen entrée meals (total caloric intake approximately 1400 kcal/day) and, therefore, findings may not be completely comparable (27). In this trial, among 16 adolescents who received topiramate plus lifestyle modification therapy, 6-month %BMIp95 reduction was 6.2 percentage points, similar to that seen among the total cohort in our study. Baseline descriptive statistics for 282 youth prescribed topiramate plus lifestyle modification therapy in a pediatric weight management clinic (February 2012–December 2020). Research has shown that topiramate affects the brain’s chemistry, reducing the urge to overeat and increasing the feeling of satisfaction after meals.At present, the clinical studies discussed in Table 1 show evidence that TPM can significantly aid in lowering overall body weight and should be considered a weight-loss medication.They can help you choose the most suitable medication based on your medical history, weight loss goals, and potential side effects.A healthcare professional should carefully monitor the patient’s progress and adjust the dosage or medication regimen as needed.Outcome measures included the number of days per week containing binge eating episodes (DBEs), BES scores, scores on the BDI, body weight, and adverse events.Future prospective studies, including clinical trials, are needed to evaluate “real-world” effectiveness and to identify and confirm potential predictors of response to topiramate plus lifestyle modification therapy in pediatric clinical settings.The placebo-subtracted weight loss (PSWL) by ITT analysis was 3.7 and 4.8% for NB16 and NB32, respectively.The dropout rate ranged from 31 to 43% for patients taking Qnexa® and 47% for the patients on placebo.One of the primary benefits of using Topamax for weight loss is its ability to promote significant weight loss, often exceeding 10% of body weight. When it comes to treating certain conditions like epilepsy, Topamax is one of the most effective treatments for reducing the occurrence of partial-onset seizures. As with all medications, results tend to vary from one person to the next. Patients should never discontinue their medication without first speaking to the doctor; however, if severe side effects are noted, seek medical care immediately. Regardless of the health condition that is being treated with Topamax, there is a risk of side effects. Adults and children who are over the age of 12, typically begin with a dose of 3.75mg of phentermine and 23 mg of topiramate. If it is recommended that a topiramate capsule become accessible and scattered on light food, do not chew the meal and swallow it right away. You can open some topiramate capsules and sprinkle them over soft foods like applesauce. Topiramate should only be taken as directed by a healthcare professional. These activities may become riskier due to some topiramate side effects, such as psychomotor slowness, disorientation, difficulty concentrating, and dizziness. Before taking Topamax, it’s crucial to inform your doctor about your medical history and any other medications you’re taking. While Topamax offers valuable therapeutic benefits, it should be used under the guidance of a healthcare professional to monitor side effects and ensure safe, effective results. Its efficacy in weight loss appears to be linked to its ability to reduce appetite and food cravings. Weight loss is generally a gradual side effect, and Topamax should be taken under the supervision of a healthcare provider due to potential side effects such as fatigue, cognitive changes, and digestive issues. Patients receiving bupropion alone or the three doses of the combination were followed for an additional 24 week-extension. With this data, it is assumed that the release of opioids has a role in the expression of food palatability, and vice-versa . Naltrexone is an opioid receptor antagonist, initially approved as a treatment for opiate addiction, and later, for alcohol dependence. It is our belief that this combination appears to provide satisfactory results, although this was not confirmed in randomized controlled studies. A large clinical series done by our group was developed to evaluate the efficacy of the combination of sibutramine and orlistat in 446 individuals for six months, with concomitant dietary counseling . To maximize Topamax weight loss, combine it with healthy habits. The best time to take Topamax for weight loss is usually in the evening, as it may cause drowsiness, which can be less disruptive at night. Typically, weight loss is gradual, with most people losing 1-2 pounds per week when paired with a healthy diet and exercise. The Topamax weight loss timeline varies from person to person. In addition to the common side effects, there are other potential side effects that can occur while taking Topamax for weight loss. These side effects are typically mild and temporary, but it is important to monitor their severity and report any concerns to your healthcare provider. As for how to take Topamax for weight loss, you have the option to take it with or without food. Many patients prescribed topiramate in our clinics are started on 25 mg daily for the first week, increasing to 50 mg for the second week, and then 75 mg until seen again in clinic, at which time further dosing changes may or may not occur depending upon response. For example, the average standard deviation (SD) topiramate dose among patients whose furthest data availability was 6 months was 36.4 ± 19.8 mg (see Supplementary Table S1). This was a retrospective cohort study performed through review of electronic health record (EHR) and baseline clinic intake survey data among children and adolescents receiving care in a U.S., Midwestern, academic health center–based pediatric weight management clinic from February 2012 through December 2020. Morning Dose: Kickstarting Your Day They can provide the best advice on how to safely and effectively use the medication. Taking Topamax at night may cause drowsiness and other side effects. It is important to speak with your doctor before taking any medication, to ensure it is right for you. This medication can help you suppress appetite, increase feelings of fullness after meals, and reduce cravings. Graphic representations of responses shown in the most comprehensive studies revealed that clinically significant changes in binge eating days per week and binge eating episodes per week should be expected after about 4 weeks of treatment, whereas effects on weight might be expected after approximately 6 to 8 weeks. While this is similar to that seen in our study, the former clinical trial also consisted of a 6-week placebo weight-loss run-in phase, a longer titration (8 weeks), and overall higher average doses (mean topiramate dose over the course for patients in our study ranged from 34.2 ± 20.8 to 39.7 ± 19.0 mg) (18). As lifestyle modification therapy alone often fails to result in clinically significant and durable weight loss (e.g., Danielsson et al. showed that 2% of adolescents with severe obesity BMI ≥ 1.2 times the 95th percentile receiving 3 years of lifestyle modification experienced significant weight loss) (2), anti-obesity medications (AOMs) have become promising adjuncts and are being prescribed with increasing frequency (3). That said, these studies all involved different populations (i.e., adults or children/adults combined), doses (generally ranging from 75 to 256 mg daily), indications (epilepsy, all indications combined), and research designs (e.g., clinical trials), and therefore, results may not be comparable (13–24). That said, one observational study among adults with obesity prescribed semaglutide showed results that were relatively comparable to those seen in a randomized controlled trial comparing semaglutide with placebo (both as lifestyle modification adjuncts) (63, 64). We are not aware of any observational studies evaluating semaglutide 2.4 mg in pediatric weight management clinical settings, likely owing to its relatively recent FDA approval. The authors reported a mean increase in weight loss from 20.4% to 34.1% in 14 patients after 90 days, without the need for band readjustment. Limitations of this study are its open-label design, small sample size, and the impossibility of distinguishing between response to treatment and placebo effects, which is known to be quite high in BED. Outcome measures included the number of days per week containing binge eating episodes (DBEs), BES scores, scores on the BDI, body weight, and adverse events. Seventeen patients (23.3% of the sample) dropped out of treatment (7 in the topiramate group, 10 in the placebo group). The rate of remission for binge eating in the intent-to-treat group was significantly higher among patients taking topiramate (83.8%) than among those taking placebo (61.1%). Additionally, some studies on rats have demonstrated that the ingestion of palatable foods (e.g., candies) leads to increased β-endorphin levels in the hypothalamus. The combination of bupropion with naltrexone (Contrave®) has been studied for some years by the pharmaceutical company Orexigen Therapeutics Inc. as a potential agent in the treatment of obesity . In contrast with our opinion, some specialists in the obesity field believe that concomitant use of drugs acting on the gastrointestinal tract with centrally acting drugs does not result in additional weight compared to the latter by itself . The benefits of Topamax include improved weight loss, decreased hunger, lower blood sugar levels, increased energy and improved mood. Topamax is a prescription drug that can help with weight loss. The success of Topamax for weight loss is dependent on proper timing and following all instructions from your doctor. Be sure to follow all instructions from your doctor when taking Topamax for weight loss. Topamax can be taken with or without food, offering flexibility in your medication schedule. Taking Topamax in the evening has several potential advantages for those using it for weight loss. Many users report that taking Topamax in the evening can help reduce late-night cravings, a common barrier to weight loss. When considering Topamax for weight loss, timing can play a crucial role. The changes in neurotransmitter activity can lead to reduced hunger and increased feelings of fullness, contributing to weight loss. If you feel that you need to stop taking topiramate, your doctor will provide you with instructions on how to do so. Even if you have never experienced a seizure, abruptly stopping topiramate can cause one. Avoid situations that could endanger you or others experiencing any of these effects. This aids them in ensuring that the treatment is safe for you. If you are worried about side effects, speak with your doctor. Discover the normal Topamax dose for weight loss, including safe starting doses, titration, side effects, and medical guidelines for best results. As research continues to investigate TPM’s role in weight loss, current data are limited for the long-term therapy of TPM and its potential side effects on a patient’s overall health. TPM treatment for at least one year yielded clinically significant results for weight loss, blood pressure control, and glucose tolerance. While Topamax can be an effective medication for weight loss, it may not be suitable for everyone. It is important to consult a healthcare provider before using Topamax for eating disorders to ensure it is appropriate for your specific condition. Studies have shown that it can help decrease binge-eating episodes and promote weight loss in individuals with these disorders. Topamax is sometimes prescribed off-label as an adjunctive therapy to help manage binge-eating disorder and bulimia due to its ability to reduce appetite and control food cravings. It’s important to work closely with a healthcare provider to monitor for side effects, especially if using Topamax long-term. The FDA approved a weight loss pill containing phentermine and extended-release topiramate (Qsymia by Vivus) on 17 July 2012 36,37. The efficacy was evaluated by patients who completed one year of their assigned dose of 96, 192, or 256 mg/day of TPM. Around 80% of the enrolled patients lost over 8% of their initial body weight, and 293 were analyzed for efficacy. The initial study was planned for sixty weeks but was cut short due to enhanced tolerability of the medication and a new controlled-release formulation for the patients’ ease. Topamax has been used for weight loss in some individuals with binge eating disorder (BED), and though it can be effective in reducing weight, it doesn’t treat the underlying issues of BED. Additionally, it’s essential to maintain a healthy lifestyle, including a balanced diet and regular exercise, to support long-term weight loss. It’s important to have regular check-ups with a healthcare professional to monitor progress and adjust the dosage or medication regimen as needed. However, for many people, the benefits of topiramate for weight loss outweigh the potential risks. Regular Medical Monitoring Research has demonstrated that the body’s natural rhythms play a crucial role in weight regulation. Understanding the optimal timing of medication dosages can significantly impact their efficacy and minimize side effects. These circadian rhythms can affect the way medications are absorbed, metabolized, and eliminated. Topiramate can be used in conjunction with other weight loss medications, such as phentermine, under the guidance of a healthcare professional. It will also be relevant to perform direct comparisons of the benefits and adverse effects of topiramate with those of other drugs that have been shown to be effective in reducing both binge eating and body weight in controlled trials, such as sibutramine, zonisamide, and atomoxetine. Baseline binge frequency was defined as the frequency of bingeing at the beginning of treatment with topiramate for patients who received placebos in the double-blind period of the study. We included both kinds of studies in the belief that the effects of topiramate both under ideal conditions (efficacy studies such as RCTs) and routine clinical situations (effectiveness trials such as those reporting on the effects of topiramate as an add-on to other psychopharmacologic treatments) can contribute to treatment of this disorder. Given its potential role in stabilizing mood and reducing impulse control problems and weight, topiramate has been proposed as a treatment for obese patients with binge eating disorder (BED). Concomitant ingestion of food slows the time required to reach peak plasma concentrations but does not substantially alter the extent of absorption.This result is very relevant and shows us how important is to study and publish more about this issue .Appolinario and colleagues19 assessed the efficacy and tolerability of topiramate in a group of obese binge eaters with no neuropsychiatric comorbidity in a 16-week, open-label study.This suggests caution in interpreting data, as the effects of long-term treatment with topiramate have not been extensively investigated.And that means splitting your fiber supplement up throughout the day.While it’s not FDA-approved for weight loss, many doctors have started prescribing it off-label for this purpose.When considering Topamax for weight loss, timing can play a crucial role. They can evaluate your situation, discuss the potential benefits and risks, and monitor your progress throughout the treatment. They can prescribe the optimal dose based on your individual needs and adjust it as necessary. They are knowledgeable about the medication and can provide personalized advice based on your specific situation. They can evaluate the potential benefits and risks, determine the appropriate dosage, and monitor your progress throughout the treatment. This helps maintain a steady level of the medication in your system, ensuring its effectiveness. This article will detail what Contrave is used for, how it works, what you should consider before taking it, and how it stacks up to other prescription weight-loss drugs. Qsymia is not appropriate for every patient seeking to manage their weight. It is important to note that Qsymia has been shown to cause adverse effects. Qsymia contains the active compound in Topamax—topiramate—combined with phentermine, an appetite suppressant. Accordingly, those who lost greater than 8% of their initial weight received 96 mg/day and 192 mg/day or the placebo. Obese patients may experience greater weight loss with continued therapy longer than one year. Thirty-eight patients were evaluated from baseline to three months and one year of topiramate treatment. It was an uncontrolled, prospective trial in which topiramate was added to the patients’ medication regimens who were already taking anticonvulsants for partial-onset seizures. Topiramate proved effective for weight reduction and increased glycemic control in patients with metformin treatment for type 2 diabetes. In addition, sibutramine was taken off the European market in 2009 due to the results of the Sibutramine Cardiovascular OUtcomes Trial (SCOUT) which showed increased cardiovascular mortality in patients using the medication in the group with prior cardiovascular disease.According to the authors, at the time of the study there were not sufficient placebo vials which explained the non-inclusion of this group.Consistency will help regulate your body’s internal rhythms and optimize the medication’s effects.Common side effects of Topamax include tingling in the hands and feet, loss of appetite, weight loss, and difficulty with concentration.Some authors have raised doubts about the tolerability of topiramate, drawing on data from the epilepsy literature; however, the dosages used in BED patients seem to lead to a somewhat milder adverse effect profile.In addition to the common side effects, there are other potential side effects that can occur while taking Topamax for weight loss. This can help to enhance its effectiveness and provide a more comprehensive approach to weight loss. Increases in dosage should be made gradually, and regular check-ins with a healthcare provider are necessary to monitor progress and adjust the dosage as needed. The recommended dosage of Topamax for weight loss varies depending on the individual and their medical history. Study design and participants Our comments section is a place where readers can engage in healthy, productive, lively, and respectful discussions. Give it a try, and you may be surprised at how much fuller you feel and how naturally you start eating less. And that means splitting your fiber supplement up throughout the day. It is important to use the lowest effective dose to minimize the risk of experiencing these side effects.Even if someone else has the same disease as you, do not share topiramate with them.Reported side effects were transient and included paresthesia (the most common, experienced by 4 patients), fatigue, somnolence, psychomotor slowing, impaired concentration, and nausea.People who take Topamax for these disorders frequently report experiencing weight loss as a side effect.Determining effectiveness of AOMs plus lifestyle modifications in clinical settings is important, as this may differ compared to outcomes seen in clinical trials that historically have enrolled highly selected populations that may not adequately represent those seeking medical care more broadly.This can help to enhance its effectiveness and provide a more comprehensive approach to weight loss.As the obesity epidemic progresses worldwide in an alarming scale, development of new therapeutic strategies, in which combination of drugs are included, is of crucial importance. We therefore additionally examined reasons for missing outcomes data, including losses to follow-up, no data within analysis window, topiramate discontinued by provider, and data censored due to additional weight-altering medication(s) (including non-weight management related) started or doses adjusted within analyses windows. We chose to increase the allowable encounter window for later visits as weight loss is generally nonlinear often greater earlier in courses as seen in AOM clinical trials (28–30), and given the practical consideration that follow-up over time will occur more sporadically. Further, if other weight-altering medication(s) were adjusted (e.g., dose increased/decreased), data from beyond that time was also censored for similar reasons. If a patient was started on additional medication(s) for obesity treatment (i.e., initially started on topiramate, 3 months later phentermine was added), only data from prior to additional medication(s) being initiated were included in analyses given the goal of assessing topiramate plus lifestyle modification response. Our goals in this retrospective cohort study among youth receiving care in a pediatric weight management clinic were to (1) evaluate effectiveness of topiramate plus lifestyle modification in a clinical setting and (2) identify potential baseline phenotypic characteristics that may predict better or worse response to this intervention. The EQUATE phase 2 study evaluated 776 patients for a period of 28 weeks (including a 4-week titration phase), where the patients were randomly selected for placebo, phentermine or topiramate in monotherapy in the medium and high doses and Qnexa® in medium and high doses . Some studies in the early 2000s proved the efficacy of this drug to reduce the weight of obese patients (in tested doses of 64 to 384 mg/d) , a fact previously observed in clinical trials involving normal and obese epileptic patients. In some short-term studies of treatment of epileptic patients with zonisamide, weight loss was observed as a side effect . The combination of ephedrine and caffeine (20/200 mg) three times a day (tid) for 24 weeks proved to be more effective for weight loss than placebo or monotherapy with its components . Patients who discontinued topiramate because of adverse effects were not taking a higher dose than those who discontinued topiramate for other reasons (225 ± 179 vs 326 ± 282mg/day).It was also found in other phase 2 studies that naltrexone SR resulted in fewer side effects compared to the IR formulation .However, further research is needed to fully comprehend the underlying mechanisms behind the weight loss effects of Topamax.These figures corroborated, therefore, the hypothesis that the combination of pramlintide with metreleptin would have a potential role in the treatment of obese humans.We did find that 15% of those prescribed topiramate plus lifestyle modifications were from non-primary English language speaking families, and as surveys were only available in English until 2021 this led to higher percentages of those not completing surveys being from such families, potentially limiting generalizability.The recommended dosage of topiramate for weight loss varies depending on the individual and their specific needs.Supposedly, the light stimulative effect of phentermine on the CNS could overcome the negative effects of topiramate on memory and cognition.Numerous studies have investigated the use of Topamax for weight loss.A double-blind randomized pilot study with 60 patients, showed after 16 weeks a weight loss of 6.0% vs. 1.0% of for zonisamide in monotherapy (usual dose of 400 mg/d) and placebo, respectively, in association with a hypocaloric diet with a 500 kcal/d deficit . One of the primary benefits of using Topamax for weight loss is its ability to promote significant weight loss, often exceeding 10% of body weight. It’s important to note that Topamax is a prescription medication, and it should only be taken under the guidance of a healthcare provider. Remember, weight loss is not just about taking a pill – it’s about making sustainable lifestyle changes that promote overall health and wellness. Further prospective cohort trials involving higher doses i.e., often used in pediatric obesity management often range from 50–100 mg daily (27, 59) and not including run-in interventions among children and adolescents are needed to better evaluate how response in clinical settings may compare to those in these clinical trials. In a separate longer term dose-ranging placebo-controlled trial, those receiving 92 mg topiramate plus lifestyle modification therapy experienced a mean 2.6 kg/m2 BMI reduction after approximately 1 year (18). As for how our results compare to those from pediatric clinical trials, to our knowledge there has only been one trial performed evaluating topiramate plus lifestyle modification among adolescents with obesity (27). In a 2013 trial, 69 patients who underwent identical lifestyle modifications for 32 weeks were given either topiramate or a placebo. We are aware that topiramate can result in noticeable weight loss, but how does this work? Pairing Topamax with a healthy diet and exercise, like tracking macros for weight loss, can boost your results. Qsymia, a combination of topiramate and phentermine, is another option for weight loss. Contrave is FDA-approved as a weight management aid for patients with obesity or individuals who are overweight and have a weight-related health condition. Wegovy, a brand-name medication containing semaglutide, is specifically approved for the treatment of obesity in patients without type 2 diabetes. It is most effective for weight loss at higher doses, which can increase the risk of adverse side effects. Discover how clinically-proven weight loss medication can help you achieve your weight management goals for just $99/mo. If you begin to notice the side effects of topiramate, seek medical advice from a licensed healthcare provider. One point of interest observed in these studies was the continuation of weight loss for over a year of treatment, without the plateau usually seen after around six months with the use of other existing drugs. A 24-week long study of 320 patients showed by ITT analysis loss of 7.5%; 6.1% and 1.4% of initial weight for the combination of bupropion with zonisamide, 360 mg/d (ZB360), zonisamide, 120 mg/d (ZB120), and placebo, respectively (PSWL of 6.1% for ZB360 and 4.7% for ZB120) . The lower weight loss seen in the patients receiving NB48 was justified by the higher dropout rate (63%) due to side effects in this group. The synergistic effect of this combination was proven in studies in rodents, in which a reduction in food intake was shown both in lean and diet-induced obesity mice, compared with both drugs in monotherapy and placebo . For many patients, emotional eating is a significant barrier to weight loss. In several randomized controlled trials, patients treated with Topamax experienced statistically significant weight loss compared to those given a placebo. Because Topamax is not officially approved for weight loss as a standalone treatment, there is no universally established “standard” dose for this purpose. Working together, you and your doctor can make sure you are getting the most out of this medication. Regular check-ups with your doctor are recommended to make sure the medication is working as it should. It is important to keep track of your progress and any changes in your body while taking Topamax. Be sure to follow your doctor’s instructions carefully to ensure the medication works properly and safely. While Topamax can aid in weight loss, it is essential to be aware of the possible side effects. Consulting with a healthcare provider is crucial to ensure that the dosage and treatment plan are suitable for your specific needs. Firstly, they can determine if Topamax is the appropriate medication for your weight management goals and overall health. Numerous studies have investigated the use of Topamax for weight loss. We guarantee you will reach your weight loss goal as determined by your physician within the first 90 days. Nu Image Medical® specializes in weight loss, hormone replacement, sexual health, and general wellness. Medication alone is rarely sufficient for sustained weight management. Navigating the world of health insurance can be daunting, especially when you’re trying to understand specific coverages like GLP-1 benefits Understanding the Longevity of Retinol Products Transform your mental health journey with our top practitioners. Save my name, email, and website in this browser for the next time I comment. By understanding these guidelines, you can make informed decisions about when to take Topamax and improve your overall experience with this medication. Topiramate raised metabolic rate and sharply decreased food consumption. Use effective birth control while taking topiramate if you are capable of getting pregnant. Use a precise measurement tool to determine your dosage if you are taking topiramate oral liquid. Find out from your doctor or pharmacist how to take your medication. The medication is usually taken with or without food once a day in the morning.These activities may become riskier due to some topiramate side effects, such as psychomotor slowness, disorientation, difficulty concentrating, and dizziness.If you’re considering taking Topamax for weight loss, it’s important to speak to your doctor first.The most common side effects shown were headache (13–15%), insomnia (12–15%) and nausea (8–12%).In recent years, Topamax has also been prescribed to those who are struggling to lose weight.Our review focuses on the rationale for their use, with advantages and disadvantages; on combinations often used, with or without studies; and on new perspectives of combinations being studied mainly by the pharmaceutical industry.Patients should never discontinue their medication without first speaking to the doctor; however, if severe side effects are noted, seek medical care immediately.All healthcare decisions should be made with your individual healthcare provider.Most adverse treatment events were related to minor central nervous system problems. For example, among those in whom topiramate was discontinued by a provider, we could not fully ascertain the rationale (e.g., side effects, not effective, effective but potentially more effective option available e.g., semaglutide 2.4 mg U.S. FDA-approved in 2022 and by the EMA in 2022). First, this was an observational study performed through EHR data review, which may be incomplete and relies on practitioners and clinical staff correctly and accurately entering all information (65). A strength of this study is our sizable cohort of youth treated in a pediatric weight management clinic over an 8-year period. That said, presence (vs. absence) of baseline depressive symptoms with 3- and 6-month, anxiety symptoms with 6-month, and binge eating tendencies with 12-month %BMIp95 changes, among others, all showed more meaningful associations with topiramate response. Research has shown that topiramate affects the brain’s chemistry, reducing the urge to overeat and increasing the feeling of satisfaction after meals. It works by increasing the feeling of fullness and suppressing appetite, making it easier to stick to a diet and lose weight. Aim to drink at least eight glasses of water per day, and avoid caffeine, which can exacerbate dehydration. Dehydration can lead to increased side effects, such as dizziness and lightheadedness. To maximize the effectiveness of topiramate, it’s essential to establish a consistent dosing schedule. Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study. TPM can aid in lowering the baseline BMI and aid in improving glycemic control, especially in obese patients. As the blood concentration of topiramate increases, the proportion of bound topiramate decreases.