If these lifestyle changes are not enough to help you lose weight or maintain your weight loss, your health care professional may prescribe medications as part of your weight-control program. In addition to prescriptions (including sexual health support and weight-management medications like GLP-1s), Midi offers lifestyle guidance for nutrition, exercise, sleep, and stress management. Even with the best telehealth service and medications, staying consistent with your weight loss journey is essential for achieving long-term success. The most effective weight loss telehealth platforms offer access to GLP-1 medications like semaglutide and tirzepatide. That could look like combining a GLP-1 with one of the existing treatments for fatty liver disease.If you build steady routines early, many people stabilize before changes become frustrating.University Hospitals offers a range of medically-supervised weight loss programs that include weight loss surgery, non-surgical weight loss procedures and nutrition-based programs.Freya Meds does not directly provide medical or pharmacy services and payment does not guarantee the writing or dispensing of a prescription.Interactions may occur during or within 14 days following the use of monoamine oxidase (MAO) inhibitors, sympathomimetics, alcohol, adrenergic neuron-blocking drugs, and possibly some anesthetic agents.The advancements in technology, a more sedentary lifestyle, along with increased access to high-calorie foods, have become the fundamental cause of the increased prevalence of obesity .“This approach can be a good start for those looking for meal ideas or (who) need something quick and easy to fit into a busy lifestyle,” says Lacy Puttuck, registered dietitian who specializes in weight loss and weight management. Weight loss medications can be expensive, with prices ranging from $5 to $1,619. On average, users lost 11 to 22 pounds, with 40% losing 5% of their body weight and 20% losing 10% or more of their body weight. Studies show that it helps people lose a significant amount of weight. It combines phentermine to reduce hunger with topiramate to control weight. GLP-1 GENIUS Obesity is recognized as a major pandemic of the 21st century, contributing to increased morbidity, mortality, and the burden of healthcare costs (1). But it's not clear whether these benefits are from the medicine or a result of weight loss. Many people who take these medicines also see their blood pressure improve. Treatment guidelines recommend consideration of additional therapies such as pharmacotherapy and bariatric surgery when lifestyle intervention alone has not achieved sufficient weight loss to improve health or quality of life.45678 This page summarises the evidence for the use of medications, gastrointestinal devices and bariatric surgery to treat adults with overweight and obesity. Treatment guidelines recommend consideration of additional therapies such as pharmacotherapy and bariatric surgery when lifestyle intervention has not resulted in sufficient weight loss to improve health or quality of life. Prescription medications to treat overweight & obesity. Working alongside a healthcare professional can reduce the risk of weight regain after coming off of Plenity and ensure you achieve the best results possible with the least side effects. People in a study on Wegovy showed a more than 15% weight loss at the maximum dose. “In 2018 only one-half percent of everyone eligible to be on weight loss meds were on them.” Weight loss medicines aren't new. Some people might believe these drugs are the “magic bullet” they have been waiting for. By Joan Tupponce Turn on the television any time of the day or night and within minutes you'll probably see a catchy commercial for an injectable weight loss drug. Contraindications vary depending on the medication; therefore, continuously monitor for side effects and potential drug interactions. Who’s Leading the Program? Hundreds of fad diets, weight-loss programs and outright scams promise quick and easy weight loss. Follow these proven ways to lose weight and boost your health. This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Orlistat at a lower dose of 60 mg 3 times daily (trade name Alli) is approved for over-the-counter use in the United States (51). The latency period to reach significance for differences in all cancers between the treatment groups was a little over 2 years, and although the overall cancer rates were low, the FDA felt that benefits of lorcaserin could not yet be judged to outweigh this adverse risk. Drug approval in the 1940s necessitated only proof of efficacy beyond placebo; evaluation of benefit versus risk with controlled investigations was not a requirement until passage of the Kefauver-Harris amendment in 1962. The associations between obesity, central obesity (increased waist circumference, especially intra-abdominal/visceral fat) and the risks for cardiometabolic diseases as well as obstructive sleep apnea, asthma, and nonalcoholic fatty liver disease (NAFLD) are well established (8,9). Obesity is a major risk factor in the development of cardiovascular disease (CVD), type 2 diabetes (T2D), musculoskeletal disorders, and several cancers (2). EMERGING ANTI-OBESITY MEDICATIONS UNDERGOING CLINICAL TRIALS People with heart conditions or a history of substance abuse should not take it without careful consultation with their doctor. The drug is a stimulant, and is thought to help with weight by suppressing the appetite. Nevertheless, for obvious reasons, orlistat users are strongly advised to maintain low-fat diets while on the medication. Generally considered safe and well-tolerated, some side effects of metformin may include stomach upset, as well as mild nausea or diarrhea. Like other drugs on this list, metformin is thought to help regulate appetite. And it often beats fast weight loss for the long term. Your healthcare professional might be able to connect you with weight-loss support groups or refer you to a registered dietitian. Tell your healthcare professional about your past efforts to lose weight. Before you start a weight-loss program, talk with your healthcare professional. He also pointed to an "activation of consumers," where patients are starting to call their employers and ask why their benefits don't cover obesity drugs. In a subgroup of individuals with elevated LDL-C, blood pressure, or HOMA-IR, there was a greater reduction in LDL-C, resolution of hypertension, and reduction in HOMA-IR in those treated with Gelesis100. Overall, there were no significant differences between Gelesis100 or placebo in cardiovascular risk factors of LDL-C, HDL-C, triglycerides, systolic BP, diastolic BP, or HOMA-IR. The efficacy of Gelesis100 was evaluated in the Gelesis Loss of Weight (GLOW) randomized double-blind placebo-control trial (112). You can list a healthy action that you'll use to lose weight. Make a list of reasons why weight loss is important to you. Talk with your healthcare professional if you need help taking charge of stress. But the best way to lose weight and keep it off is to make lasting lifestyle changes. Possible side effects vary by medication and how it acts on your body. For this reason, never take a weight management medication only to improve the way you look. Most weight loss takes place within the first 6 months of starting the medication. Losing weight also can improve some other health problems related to overweight and obesity, such as joint pain and sleep apnea. If you are overweight or have obesity, you might be able to lose weight with a lifestyle program that changes your behaviors and improves your eating and physical activity habits. These GLP-1 receptor agonists are very effective, with studies showing significant weight loss medication comparison chart. Zepbound (tirzepatide), a dual GIP/GLP-1 receptor agonist, is also approved for the treatment of obesity in adults. Ozempic, another once-weekly semaglutide injection, is approved for type 2 diabetes. In bigger studies, semaglutide can help people lose up to 14.9% of their weight. Most people will regain some or all of the weight after they stop taking the medicines, unless they have made lasting lifestyle changes. While weight-loss medicines can be helpful, the overall weight loss achieved is limited for most people. Before trying weight-loss medicines, your health care provider will recommend that you try non-medicine ways for losing weight. Melissa Mitri is a registered dietitian-nutritionist, weight loss specialist, and expert health writer with over 18 years of experience in the health and wellness industry. Keep in mind that the key to losing weight is a whole lifestyle approach that involves eating well and moving more. Ephedra (ma-huang) is an herb once used for weight loss. Ideally the trial would have hundreds of people that researchers watched for side effects. Bariatric surgery No one else can make you lose weight. So be sure that you're ready to eat healthy foods and become more active. Here are six tips to help you start your weight-loss journey. These healthy changes include eating a balanced diet and moving more each day. Your prescription gets approved and ships straight to your door in discreet packaging within 3–5 business days.This Medicspot guide will help you understand how different medications support healthy, sustainable weight loss and when they may be prescribed.Short-term studies and meta-analyses in individuals with obesity and without prediabetes/diabetes consistently demonstrate ~2% weight loss beyond placebo, with a greater response in those with more insulin resistance (124).You have access to your provider via messaging for three months for medication monitoring and support.Discover the power of GLP-1 and GIP medications to support your weight loss journey.She notes that there are ways for people to slowly taper off GLP-1s and keep the weight off.This increases the risk of other diseases, including hypertension (high blood pressure), diabetes and high cholesterol. After the initial visit, you’ll have access to unlimited wellness coaching, lifestyle strategies, meditation and audio tools, and educational resources. It’s designed for women aged 35 to 70 and pairs medical visits and prescriptions as needed with ongoing wellness coaching, symptom tracking, guided audio tools, and access to a digital community through the Stella app. Wisp offers hormone therapy for patients aged 40 and older or for younger folks who have had a hysterectomy with ovary removal. You have access to your provider via messaging for three months for medication monitoring and support. Overall, Hone Health is designed for menopause support that addresses symptoms while also extending to longevity and lifestyle optimization. Bourla estimated that the direct-to-consumer channel already makes up 30% of the obesity and diabetes drug market in the U.S. That appears to have more potent effects on a person's appetite and satisfaction with food than other treatments. He said adding Wave's injection on top of a GLP-1 won't make it more difficult for patients to tolerate the treatment regimen, so it makes the company's drug "very amenable to combination" options. "We can double the weight loss on GLP-1s in combination," Bolno said, referring to what the company is seeing in preclinical research. Bolno said the company is developing the injection, called WVE-007, as a monotherapy or a potential maintenance treatment that patients can switch to and take far less frequently after being on GLP-1s. All of these drugs, which are typically administered once a week by self-injection, work best when combined with healthy eating and exercise. Similar to semaglutide, tirzepatide mimics the actions of GLP-1, but it also targets a second naturally occurring hormone, known as GIP (glucose-dependent insulinotropic polypeptide), which is also involved in blood sugar control. Both drugs, which are made by Danish drug manufacturer Novo Nordisk, mimic the action of a hormone called GLP-1 (glucagon-like peptide), which occurs naturally in the body. This drug, available in injectable form but also as a pill, was originally approved in 2017 for diabetes. It is also believed to reduce leptin levels in the body, which may additionally contribute to weight reduction. Still, for people with significant weight issues, the risk is worth the reward. In rare cases, some people may have an allergic reaction to the drug, or be at risk for a dangerous buildup of lactic acid in the bloodstream. It also appears to affect the gut microbiome in a manner that may improve metabolism and support weight loss. It works by mimicking two hormones—GLP-1 and GIP—which can make it even more powerful than semaglutide alone. Yes, they can, especially when combined with healthy habits like diet and exercise. “Many patients who really benefited from them have had to scramble to get them,” Dr. Obici says. For much of 2023 and 2024, these drugs have been plagued by shortages in the marketplace. “When educated properly, most patients do really well,” Norinskiy says. Treatment options include hormone therapy, GLP-1s, prescription skincare, hair-loss treatments, support for vaginal health, and more. This care includes visits with a physician and a dietitian, lab work, and, in some cases, weight-loss drugs such as GLP-1s. Gennev is another platform that integrates medical care with ongoing nutrition and lifestyle support from RDs. Safety and Side Effects GLP-1 receptor agonists, such as semaglutide (Wegovy), lead to 9.6-16% weight loss. Traditional meds like phentermine and orlistat result in 5-10% weight loss. GLP-1 receptor agonists, such as Wegovy, offer the most significant weight loss medication comparison chart. Those with a BMI of 27 or higher and health issues like diabetes or high blood pressure may also qualify. As new weight loss drugs come out, keep learning and talking to your doctor. Older AOMs also have indications based on BMI and may be contraindicated for use with certain other medications. Bupropion (Wellbutrin), an aminoketone, is considered weight-negative and is prescribed both to assist in weight loss and to treat depression. Desipramine, nortriptyline, and protriptyline have variable effects on weight. Weight-positive medications in the tricyclic antidepressant category include amitriptyline, doxepin, and imipramine. More treatment options and wider access could boost the case for analyst projections that say the weight loss and diabetes drug market could be worth almost $100 billion annually by the end of the decade. The future of the booming obesity drug market won't hinge on drugs that deliver greater weight loss alone. Novo Nordisk’s CagriSema falls short of 25% weight loss target in patients with obesity or overweight. If only one pathway is targeted, as in monotherapy, this can lead to the occurrence of compensatory mechanisms, which reduces drug efficacy; the use of phentermine/topiramate as a combined therapy can overcome these compensatory mechanisms. Topiramate is a gamma-aminobutyric acid agonist, glutamate antagonist, and carbonic anhydrase inhibitor; it is a drug used for epilepsy treatment and migraine prophylaxis (Pilitsi et al., 2019). Phentermine is a centrally acting sympathomimetic that enhances the release of serotonin, norepinephrine, and dopamine (Pilitsi et al., 2019). The program focuses on the cognitive process of eating behaviors, helping individuals build healthy habits to adapt to a healthier lifestyle, Jaelin says. Rated best weight loss app for behavior modification by Healthline in 2025 and second best diet program by U.S. “For effective behavior change, especially in weight loss, peer accountability is key,” Mok says. “When you become a member of a chapter, you’re joining a group of people with similar healthy living goals. Bariatric surgery decreases weight and weight-related complications,20,21 but the invasive nature of surgery and its small risk of causing serious adverse events leads to a significant ongoing unmet need for pharmacological treatment options. Without more high-quality clinical trials that will lead to the approval of more medications for children and adolescents, providers are left with only limited tools to effectively treat this population. More research is needed to develop additional pharmacotherapy for the treatment of obesity. Combination therapy could also allow for lower doses of each medication to mitigate side effects.83 Drugs currently under investigation include centrally acting agents, gut hormones and incretin targets, leptin analogs, dual action GLP-1/glucagon receptor agonists, and lipase inhibitors. Prescription medications to treat overweight and obesity work in different ways. “Zepbound is the most effective FDA-approved medication for weight loss to date, based on head-to-head trial data,” says Dr. Holmes. While no specific vitamin or supplement is considered a “treatment” for obesity or overweight, certain ones help support metabolic health. Your healthcare professional can tell you if weight-loss medication is right for you.They specialize in medications like Ozempic® and Wegovy® and create customized programs based on user needs.Most weight loss with the drug occurs within the first few months.It guides you in choosing the best for your weight loss medication comparison chart journey.This mechanism has been shown to be the culprit in the malabsorption of several psychiatric medications, manifesting as unsatisfactory mental outcomes .Innovent announces Mazdutide, first dual GCG/GLP-1 receptor agonist, received approval from China's NMPA for chronic weight management.The weight loss list is focused on the most effective eating plans for losing weight and sustaining weight loss, while the best overall diet prioritizes weight management and healthy eating.Some research has indicated that using moderate amounts of MCT oil as a dietary supplement — perhaps one or two tablespoons per day — may help suppress appetite, promote feelings of fullness and so help maintain a healthy weight. You want to get healthier, we have the script! Some people lose 10 pounds in the first month, others take longer. Some programs offer refunds if you’re not approved (like HealthRx), but not all. I was approved the first time, and when I tested the second version, they refunded me quickly and without any hassle. I’ve looked into each one carefully so you don’t have to figure it all out alone. 🤢 Side effects can happenThe most common are nausea, fatigue, constipation, or digestive issues—especially in the first few weeks. 💊 The meds don’t work the same for everyoneSome people see results quickly. Take a micro shot once a week, follow our guides and lose weight fast. De Guzman is a longtime health and fitness enthusiast who is interested in nutrition, diet, and mental health. He has a background in investigative and science journalism and has worked on documentary films about war and trauma, health, sanitation, and the changing climate around the world. Orlando de Guzman is a writer and editor with expertise in health and environmental news. If you have lost enough weight to improve your health and are not experiencing serious side effects, your health care professional may advise you to stay on the medication indefinitely. Choosing a medication to treat overweight or obesity is a decision between you and your health care professional. In the past, some weight management medications were linked to serious health problems, and they were removed from U.S. markets. Experts are concerned that, in some cases, the side effects of prescription medications that treat overweight and obesity may outweigh the benefits. One study he cites in the book showed that 40% of the weight loss in patients on once-a-week injections of semaglutide came from lean body mass. We share expert advice on GLP-1 medications, offering clear, evidence-based insights into their benefits, safe use, and practical guidance for weight management and better health. If you’re interested in GLP-1 weight loss injections, platforms like RemedyMeds, Ro, and FuturHealth are excellent options as they provide access to proven medications like semaglutide and tirzepatide. Their promise of percent weight loss is enticing to those who haven’t had success with diet and exercise alone,” says Dr. Khaitan. He also works in addiction medicine and is passionate about combating homelessness, decreasing substance abuse, improving mental health and elevating extraordinary stories from everyday people. News and World Report in 2025, the Keyto diet is a low-carbohydrate diet that emphasizes Mediterranean diet foods and fats that help people “lose weight with no hunger,” according to its website. Eating a ‘recharge bar’ at the end of the fasting period simply shortens the fast, but any weight loss achieved on this or any other approach is likely to last only as long as you continue the program, she says. “It is designed for the user to understand diet and nutrition, make the user more empowered and educate them on healthier diet and lifestyle choices,” she adds. Tirzepatide (brand name Mounjaro®) is also administered by subcutaneous injection once a week and is a glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist.14 Tirzepatide (Mounjaro®) is approved in Australia for obesity management. Bariatric surgery is the most efficacious long-term treatment for obesity and should be considered along with individual circumstances Prescription weight loss drugs; Diabetes - weight loss drugs; Obesity - weight loss drugs; Overweight - weight loss drugs If you have diabetes that needs treatment with medicines, you may want to ask your provider about diabetes medicines that often lead to weight-loss. Consider whether the cost, side effects, and the small weight loss you can expect are worth it to you. Obesity is highly prevalent worldwide, and the percentage of affected individuals is rising, making obesity a disease that needs to be more highly addressed. Nephrolithiasis is also a possible side effect due to topiramate’s inhibitory effects on carbonic anhydrase.1,37 Dose escalations are weekly, and the drug administration is daily via subcutaneous injection.33,55 Liraglutide should not be used in patients who are pregnant, have personal or family history of medullary thyroid carcinoma or type 2 multiple endocrine neoplasia. Obesity treatment using liraglutide starts at 0.6 mg, and the dose is titrated to the targeted dose of 3 mg. If a patient taking a monoamine oxidase inhibitor (MAOI) wants to start Contrave, at least 14 days should elapse between MAOI discontinuation and the start of Contrave treatment.42 In addition, a patient’s mental status should be monitored and specifically, for any indications of suicidal ideations or depression.1 They can help you lose 3% to 12% more than just changing your lifestyle. Phentermine is the most affordable, priced at $5-$44, while Liraglutide and Semaglutide are the most expensive. Orlistat, Phentermine-Topiramate, and Naltrexone-Bupropion have prices ranging from $41 to $823. This is due to the average wholesale price (AWP) of these drugs. Results from 1-year clinical trials were extrapolated to estimate lifetime treatment benefits, with assumptions of continued adherence and treatment effectiveness. When prescribed as combinations of their generic components, phentermine/topiramate appeared cost-saving, whereas bupropion/naltrexone was cost-effective. In contrast, branded phentermine/topiramate was cost-effective, primarily because of its lower price. Two well-known weight loss medication comparison chart are phentermine and orlistat. These FDA-approved medications, such as Wegovy (semaglutide), Ozempic, and Zepbound, are making a significant impact. The world of weight loss medication comparison chart drugs has changed a lot lately. They are a doctor-led weight loss service available to the public with or without medical insurance.During your first video appointment, your doctor and dietitian will develop a personalized weight loss plan, which may include diet, exercise, behavioral health, and FDA-approved brand-name GLP-1 medication.Obesity medicine specialists at University of Utah Health understand the complex causes of weight gain.These include food intake, how much you exercise and your health status.The platform offers medical care with movement, nutrition, sleep optimization, stress support, and symptom-tracking tools. Comparing Effectiveness and Weight Loss Potential It’s an injectable medication that mimics GLP-1 but blocks GIP. People taking a placebo lost only about 1% during the same time. A tablet version of the medication is also in the works, but it’s in earlier stages of development. In a recent 48-week phase 2 study, over 80% of people who received survodutide experienced significant improvements in their liver biopsy reports. To help provide clarity around weight loss supplements, we asked three registered dietitians to share the ones they recommend to their clients. It’s also important to note that clinical research and safety data on weight loss supplements varies, and clinical guidelines don’t generally include weight loss supplements. Others, like collagen, may support weight management more indirectly by promoting satiety and reducing appetite. Body weight often plateaus before increasing again after treatment cessation (Christoffersen et al., 2022). However, guidelines suggest different weight targets are set depending on the complications, such as 5-15% weight loss for metabolic syndrome, type 2 DM and cardiovascular disease, 7-8% for obstructive sleep apnea and asthma, and 10-40% for steatohepatitis (Garvey et al., 2016). Approved in 1959, phentermine (Adipex) can be prescribed for weight loss, but it’s not for long-term use.This means you need to find a weight-loss approach you can embrace for life.With traditional weight loss programs, these are mostly done face-to-face.By joining, you will have access to a certified clinician offering valuable one-on-one consultation regarding your weight and health.Noom focuses on changing your behavior towards eating and weight care, which is helpful in the long run.It is also believed to reduce leptin levels in the body, which may additionally contribute to weight reduction. Some brand-name GLP-1s may be covered if you meet certain medical criteria, but cash-pay programs are the norm. Nausea, fatigue, and digestive issues are common at first—but a good provider will help you adjust your dose or pause treatment if needed. Whether you need to lose 20 or 100 pounds, Eden provides the guidance and medical oversight to make it happen. Like others on this list, Prime Health has an easy online quiz, fast provider review, and home delivery if approved. In November 2023, tirzepatide became the first GLP-1/GIP dual RA approved by the FDA for chronic weight management.However, in 2014, the FDA did approve Contrave, a medication that combines bupropion and naltrexone, a drug historically used to treat alcohol and drug addiction, but which also impacts parts of the brain that control appetite.A study from FAIR Health published in May 2025 reports that more than 2% of U.S. adults took a GLP-1 for weight loss in 2024.Qsymia® is a combination of phentermine and topiramate and acts as a norepinephrine and gamma-aminobutyric acid agonist, as well as a glutamate antagonist leading to appetite suppression (although the exact mechanism is still under investigation).31,32For many years, patients struggling with weight loss were told that success simply required more willpower – eat less, exercise more and the weight would eventually come off.When weight gain happens, it is often gradual and influenced by more than the medication alone.It’s injected weekly and is often used off-label for weight management. They appoint well-trained medical weight loss experts to each person. If you choose to join the program, you will get an individualized weight loss program designed by an expert primary care doctor. They are a doctor-led weight loss service available to the public with or without medical insurance. PlushCare is undoubtedly one of the most trustworthy medical weight loss programs online. This online weight management program is for people struggling to maintain their weight through traditional methods. When weight gain happens, it is often gradual and influenced by more than the medication alone. Celexa can cause weight gain for some people, but it is not a guaranteed outcome. Some people gain weight gradually, some lose weight early due to nausea or reduced appetite, and many stay fairly stable. If you prefer the flexibility and increased access to care that telehealth offers, it can be just as effective.” She adds that women should discuss the option of telehealth visits with their gynecologist at their yearly exam to ensure their in-person care is up to date. As a team, you and your provider can create the right weight-loss plan for you. The risks, side effects and cost related to taking the drug likely override any potential benefit. A weight-loss plan with diet, exercise and drug therapy is generally considered successful if you lose about 1 pound (0.5 kilogram) a week during the first month. Novo Nordisk's Wegovy® pill, the first and only oral GLP-1 for weight loss in adults, now broadly available across America. FDA approves Novo Nordisk's Wegovy® pill, the first and only oral GLP-1 for weight loss in adults. Pfizer scraps daily weight loss pill after liver injury in one patient. Many people consider Wegovy to be the strongest weight-loss pill. It’s a Type 2 diabetes medication that also has heart and kidney benefits. Weight loss medications, like those offered by FuturHealth and Hers, work best when combined with a focus on improving overall health. Here’s a breakdown of the leading telehealth weight loss platforms for 2025, highlighting their key features, offerings, and what sets them apart. One of the biggest advantages of weight loss telehealth services is their convenience. Choosing the right telehealth weight loss service can feel overwhelming, especially with so many options available. What sets telehealth weight loss services apart is their accessibility and ease of use. And many of the same health benefits experienced by Zepbound users happen for Wegovy users too. Here, Dr. Holmes and other experts help break down the pros and cons to help you find the best drug or supplement for your body and your life. Beyond how effective a drug or supplement is, we also need to consider what we can afford, personal preferences (like pills over injections) and if we can live with potential side effects. Lately, those of us who want help losing weight have more options than ever before. The active ingredient in Alli, orlistat, causes digestive side effects related to undigested fats passing through your digestive system. For some people, this timing works out best to be at bedtime. If you take Alli with a high-fat meal, you'll likely experience more-severe digestive side effects. The FDA published a safety review of orlistat in 2010 because of rare reports of serious liver injury in people using it. News & World Report is separated into multiple lists, including best weight loss diet and best overall diet. She notes that a robust maintenance plan equips individuals with the strategies and support needed (such as coaching or peer-to-peer and group support) to keep the weight off for the long term, preventing weight regain and ensuring lasting success. “It’s incredibly important for weight loss programs to include cultural foods as this directly impacts a person’s adherence, sustainability and overall wellbeing,” Mok says. It can support weight loss in adults alongside a low-fat, low-calorie diet. Up to 25% lost at least 10% of their body weight. In initial studies, orlistat helped up to 55% of adults lose 5% or more of their body weight after 1 year. Orlistat isn’t approved for kids or adolescents, and it can cause some bothersome side effects. Benzphetamine, diethylpropion, and phendimetrazine are weight-loss pills that are similar to phentermine, but they’re prescribed less often. Qsymia is currently available as a brand-name medication. Phentermine is a stimulant that lessens appetite and increases energy expenditure. And medical conditions, such as a history of certain thyroid cancers, can make GLP-1s unsafe to take. That has helped combat the weight bias that’s been so pervasive in our society for so long.” Phentermine-topiramate is not recommended for patients with significant cardiac history such as coronary disease and uncontrolled hypertension (64). Improvements in fasting glucose and insulin levels were seen in the SEQUEL study, and a 54% and 76% reduction in progression to T2D in the two treatment groups was noted in subjects without diabetes at baseline (63). In the 4-year XENDOS study conducted in Sweden, the cumulative incidence of T2D was 9.0% in the placebo plus diet and lifestyle group and 6.2% in the subjects receiving orlistat (24), corresponding to a risk reduction in development of T2D of 37.3%. In addition to promoting weight loss and maintaining lost weight, orlistat has been shown to improve insulin sensitivity and lower serum glucose levels. In other words, it's not a weight loss prescription, it's a weight loss program for yourself. We're also probably going to see more of the AI coming into it – there are apps and technologies out there now that are changing the game when it comes to weight loss. I think that we're going to see where we've really had to work with patients about how to get patients to a great place where they're healthy and fit but not overdoing it. My only fear with these new medications is the idea that, as humans, we all want to get to our goal as quickly as possible. If you can stimulate muscle mass and also promote weight loss, this is an amazing combination for aesthetics. As with many of the weight loss plans we’ve reviewed, your journey with Eden begins with a simple questionnaire about your health history, weight, and lifestyle. Consult a healthcare professional before using Priority Meds or starting any weight loss program. If you have a body mass index in the obese range, you may also want to consult an obesity medicine physician about prescription medications or surgical options. While many weight loss supplements are safe to use, some — particularly those that contain caffeine — can have risky side effects involving blood pressure, heart rate, and heart function. However, remember that the medicationss anotott effective againinfectiousediseasessa . We must better understand the scientific evidence for weight loss supplements and the effectiveness of weight loss pills. The effectiveness of weight loss pills can vary significantly. They suggest benefits for weight management through diet and exercise. Looking at scientific evidence for weight loss supplements, bitter orange has limited support. Brightside Health’s mental health treatment options can complement menopause-specific treatments. Menopause care through PlushCare begins with a virtual visit from a licensed clinician who reviews your medical history and goals. Your care with Midi begins with an in-depth health questionnaire and a virtual visit with a clinician. Here’s a summary of medication-specific ways to save. There are many ways to save on weight-loss pills. Also let them know what you’re willing to potentially spend on a weight-loss pill. The decision to start taking a weight-loss pill is a personal one. Side effects of Orlistat (Alli) include oily stools, gas, and more frequent bowel movements.The studies have been able to establish the efficacy, but data is lacking regarding long-term side effects.Providers can also help coordinate referrals for services that require in-person care.More than 20% lost at least 10% of their body weight.Structure pill leads to competitive weight loss in obesity study. Contrave (bupropion / naltrexone) is a combination weight-loss pill approved for adults who meet certain body mass index criteria. Compared to GLP-1 medications, Qsymia has different side effects and risks. During initial clinical trials, most people taking Qsymia lost at least 5% of their starting body weight after 1 year. Innovent announces Mazdutide, first dual GCG/GLP-1 receptor agonist, received approval from China's NMPA for chronic weight management. Lilly's oral GLP-1, orforglipron, is successful in third Phase 3 trial, triggering global regulatory submissions this year for the treatment of obesity. The role of pramlintide for weight loss. Amylin as a future obesity treatment. Amgen wants in on the booming weight loss drug market — and it’s taking a different approach. That's how tirzepatide, the active ingredient in Lilly's blockbuster obesity and diabetes injections, works.For dose escalation, immediate-release phentermine/extended-release topiramate at 11.25 mg/69 mg can be prescribed daily for 2 weeks followed by a final titration to a dose of 15 mg/92 mg daily for 12 weeks.They’re also controlled substances meant for short-term use.Be sure you understand the side effects of weight-loss medicines.Studies have shown that Mounjaro is more effective than Ozempic both in lowering AIC and weight.Some services also integrate behavioral science or habit-building tools to support sustainable weight management.Mental health care is often especially well-suited to telehealth, as De Angelis notes, “In terms of psychotherapy, I think that’s very individual.Prices vary, from $41 for orlistat to $1,619 for liraglutide or semaglutide. Fibre supplements, such as glucomannan and guar gum, might help you feel full and aid in weight loss. Supplements such as green tea extract, garcinia cambogia, and ginger are gaining attention for their weight loss benefits. 1 Over 40% of users lost 5% or more of their body weight in a year. While these OTC options might offer some benefits, they’re not a replacement for a healthy lifestyle. I am very excited to continue my weight loss journey with you. “Happy that there is a place affordable so I can take care of me by losing weight. It should not be considered a replacement for professional medical advice, diagnosis, or treatment. Gorgojo-Martínez et al. found liraglutide to be more effective at weight loss as well as obesity-related metabolic and cardiovascular complications than orlistat . At the one-year point, excess weight loss compared with placebo was 5.3 kg (95% CrI -6.06 to -4.52 kg). Further limitations include the inability to use naltrexone in patients taking opioid analgesics, while bupropion is contraindicated with medications that lower seizure threshold and monoamine oxidase inhibitors. At the one-year point, excess weight loss as compared to placebo was 5.0 kg (95% CrI -5.94 to -3.96). The aforementioned studies suggest that the benefits outweigh the risks of adverse effects by causing weight loss and reduction of weight-related complications when used in an appropriate patient population. Mean change in body weight was -13.3% with semaglutide and -2.6% with placebo over 52 weeks. The SELECT trial builds upon an established body of evidence (e.g., SUSTAIN-6) demonstrating the CV safety and benefits of semaglutide and is groundbreaking as the first CVOT to demonstrate secondary cardiovascular prevention with an anti-obesity medication in a population without T2D. In March 2024, semaglutide 2.4 mg received FDA-approval for the treatment of CVD in adults with preexisting CVD and obesity or overweight. Both 56-week, randomized, placebo-controlled, double-blind clinical trials demonstrated significantly greater mean weight loss than placebo (8% vs. 2.6% in SCALE Obesity and Prediabetes (28) and 6.0% vs. 2% in SCALE Diabetes (73). The findings from the STEP 4 and 5 trials underscore the chronic nature of obesity and underscore the significance of prolonged treatment to attain and maintain clinically meaningful weight loss. In STEP 4, discontinuing semaglutide after the 20-week run-in period resulted in weight regain, whereas continuing treatment with semaglutide 2.4 mg led to further substantial weight loss after 48 weeks . The outcomes of the STEP 1-3 trials revealed significant weight loss of 15% to 16% in participants without T2D and 9.6% in those with T2D, achieved through once-weekly subcutaneous semaglutide 2.4 mg in adults with overweight or obesity 33-35. Qsymia - phentermine and topiramate capsule, extended release package insert. Examples include Qsymia (phentermine / topiramate ER), Contrave (bupropion / naltrexone), and orlistat (Alli, Xenical). With a GoodRx discount, you could pay as little as $14.97 for generic phentermine tablets. By the end of the study, participants in the liraglutide 3.0 group lost an additional 6.2% compared to 0.2% with placebo (74). The FDA recommends monitoring patients for worsening or emergence of suicidal thoughts or behaviors. Bupropion/naltrexone should be avoided in patients with uncontrolled hypertension, history of seizures, history of bulimia or anorexia nervosa, and in individuals taking narcotics for pain control (69). The most common side effects of bupropion/naltrexone include nausea/vomiting, constipation, headache, dizziness, insomnia, and dry mouth. The COR-Diabetes trial enrolled patients with BMI greater than 27 kg/m2 with T2D with or without hypertension or dyslipidemia (68). The end-of-treatment heart rate increase was similar to or slightly higher than that observed with placebo (Ji et al., 2023). In a phase 1b clinical trial in Chinese adults with overweight or obesity, mazdutide up to a dose of 10 mg was well tolerated and had an overall safety profile similar to those of other GLP-1-based therapies. Thus, glucagon action can reduce body weight both by increasing energy expenditure and reducing food intake (Sandoval and D’Alessio, 2015). When co-administrated with other therapies, the weight loss effect of cagrilintide is more prominent. A phase 2 trial reported that cagrilintide 0.3 mg to 4.5 mg significantly reduced body weight by 6.0% to 10.8% at 26 weeks and was well tolerated. Every weight-loss pill, or diet pill, operates on its own timeline. The effects are less than the prescription dose. It can also reduce the risk of regaining weight after losing weight. Orlistat works by helping your body absorb less fat from the meals you eat. It’s less common than other weight-loss pills, though. The 11 Best Sites to Buy GLP-1 Weight Loss Medications Online, Reviewed by Experts in 2026 The recent surge of interest and subsequent advertising frenzy revolves around the newer anti-obesity injectable medications — Ozempic® (which is not FDA approved for obesity, just diabetes), Wegovy®, and the newest, Zepbound®. The FDA has approved several medications for weight loss. The FDA has approved several medications for weight loss medication comparison chart. Adding exercise, healthy eating, and stress relief can boost the effects of weight loss drugs. Novo Nordisk confident of amycretin obesity drug launch this decade. A study of retatrutide (LY ) in participants with obesity and cardiovascular disease (TRIUMPH-3). Lilly to advance alternative obesity candidate to phase III. Results from Amgen's phase 2 obesity study of monthly maritide presented at the American Diabetes Association 85th scientific sessions. Eli Lilly recently announced that every eloralintide dose group in its phase 2 trial hit the study’s main weight-loss goals. Approved in 1959, phentermine (Adipex) can be prescribed for weight loss, but it’s not for long-term use. In studies, users lost around 6 to 9 percent of their body weight, depending on lifestyle support. A lack of direct comparisons among the medications and differences among the trials regarding their size, patient characteristics, concomitant lifestyle interventions, outcomes assessed, and duration of follow-up contribute to indirect analyses having more uncertainty. All interventions had greater discontinuation because of adverse events than placebo in an NMA, although semaglutide appears to have lower rates of discontinuation than the other drugs. With the advent of highly effective AOMs and newer agents targeted specifically at fat mass loss, pharmacotherapy is likely to become more acceptable by society and the medical community to treat obesity as a disease. Orforglipron is a small molecule GLP-1RA that has also demonstrated about 15% weight loss in a phase 2 trial (166). Semaglutide 2.4 mg in combination with cagrilintide, an amylin analog, has been shown to cause 15% weight loss in a phase 2 trial (165). They will review your medical history and require lab testing to see if GLP-1 medication is a right fit for you. By joining, you will have access to a certified clinician offering valuable one-on-one consultation regarding your weight and health. They will take what they learn and make an individualized weight loss program. Are you seeking out a simple and straightforward online weight loss program? They deem themselves the 'sustainable weight loss program' based on a person's biology. Medication prescriptions are at the discretion of medical providers and may not be suitable for everyone. Over a 12 month period most patients have found similar results. Although our partner pharmacies are FDA approved and only use pharmaceutical-grade and highly regulated, compounded prescriptions are not FDA approved. We also provide you with a thorough Medical Weight Loss Bio-Hacking guide to help combat side effects with proper diet and exercise. Side effects can vary from patient to patient...however the #1 symptom is nausea.