This means it’s important to both consider these supplements within your larger weight loss effort, but also as standalone products. Furthermore, while over-the-counter dietary supplements are widely used for weight loss, evidence to support their safety and effectiveness is at times limited and often controversial. Whether you're aiming to shed a few pounds or embark on a transformative lifestyle change, discover which weight loss supplements are best for your health and wellness goals. Overall, most evidence shows that inulin and ITFs supplementation has a positive effect in subjects with T2D regarding weight loss, appetite suppression, glucose metabolism and systemic inflammation parameters, while such effects have not been described consistently in those with obesity but no diagnosis of T2D. Since Alli rids your body of the fat you ate, you can become deficient in some of those important fat-soluble vitamins. The Food and Drug Administration (FDA) does not regulate supplements like they do for prescription medications. Don’t you want to know exactly what is in that fancy, all-natural mixture that promises to annihilate 10lbs of body fat in one week? To give you a little more insight into supplements, let’s talk over the counter. The supplements we recommend in this guide can provide a host of health benefits other than weight loss, too. If you run a Google search for “best weight loss supplements,” the majority of web pages Google serves up will look a lot different from this one. Still, it’s best to always talk with your health care provider before trying berberine or other supplements. Some studies show modest weight loss — between 5% and 7% of body weight. Incorporating medications like Setmelanotide, Tirzepatide, or Topiramate can be particularly beneficial for those who may face challenges in achieving long-term weight loss through diet and exercise alone. Intuitive eating is about listening to your body and making peace with food.Orlistat is a well-known fat blocker that can help reduce calorie intake from dietary fats.I also aimed to include mostly third-party tested supplements at a variety of price points across various product types.Don’t forget, the word “essential” doesn’t just mean you need them, it means your body can’t produce them on its own, so you need to get them from either diet or supplementation.However, be sure to only start with one capsule to see how your body reacts before you go with a full dose.Losing weight can be easy if you are young and pretty fit.Fiber’s also great for your good gut bacteria, which is key for weight loss.“By consuming generous amounts of foods that are high in bulk but low in calories, such as vegetables and fruits, people can feel satisfied yet consume less calories” adds Hensrud, an internal medicine physician specializing in nutrition and weight management. Green tea contains caffeine, which is proposed to contribute to appetite suppression and stimulate thermogenesis (83,84). Three studies did not assess differences in weight between arms pre/post, and five studies (33%) reported significant decrease in weight. Garcinia is a plant native to India and Southeast Asia, whose rind contains hydroxycitric acid (HCA) which is purported to affect appetite by preventing fat storage blocking ATP-citralyase. In most cases, they’re prescribed because they cause weight loss as a side effect. Yes, many medications are prescribed off label for weight loss. There are multiple ways to save on FDA-approved weight loss medications, too. Used only to treat certain genetic conditions, lowers appetite, increases energy use These findings suggest a reduction in the risk for cardiovascular complications in diabetic patients after guar gum supplementation. Guar gum can be also found in several types of food such as dairy products, cereals, sauces, pudding, kefir, and baked goods . Of note, paediatric patients, or subjects with impaired glucose metabolism did not benefit from glucomannan administration to the same degree 96,97. Moreover, glucomannan is able to absorb up to 50 times its weight in water and cannot be digested by human salivary and pancreatic amylase so that it passes relatively unchanged into the colon, where it is fermented by the gut microbiota . It is a soluble fiber which is present naturally and abundantly in several products, such as softwoods, roots, tubers, and many plant bulbs . A soluble fiber has the ability to dissolve in water, forming a viscous gel that may decrease appetite by occupying the stomach and it may interfere with the absorption of carbohydrates 84,85, lipids and bile acids 86,87. Moreover, they gained nutritionists attention because of their positive activities on glucose and lipid metabolism. Finally, in vitro studies have demonstrated that chitosan can modulates adipokine secretion and inhibit adipogenesis 72,73. Moreover, chitosan has been shown to decrease lipid peroxidation in rats fed a diet enriched with cholesterol, suggesting a possible antioxidant role . Best Weight Loss Supplement for Men for Energy: Caffeine With a range of awesome ingredients and some very compelling reviews, PhenQ is a top-3 option if you want to tackle multiple elements of your weight loss journey while packing a punch with some major caffeine. We love it because it contains a range of powerful ingredients intended to help you burn fat, stop fat production, boost your energy, improve your mood, and suppress your appetite. The result is faster weight loss allowing for increased fat burning all over the body. He promotes wellness through lifestyle changes, emphasizing exercise, healthy eating, and supportive relationships in addition to traditional metric goals. While no specific vitamin or supplement is considered a “treatment” for obesity or overweight, certain ones help support metabolic health. Destini Moody, RD, says another difference is that supplements are not regulated by the Food and Drug Administration, whereas medications are. You can, of course, drink green tea if you like the taste, but don’t expect this to be a metabolism booster or fat burner that’ll melt the pounds off. “A strong green tea extract can increase energy expenditure—increasing calorie-burning while at rest,” says Bob Iafelace, RD. “The caffeine is likely the major contributor to it,” he continues. Here, we’ll cut through the noise a bit, dispelling a few myths on certain supplements and giving alternatives where need be. All the adults in the trial participated in a diet and exercise program. The FDA also can take action against companies that use false claims or claims with no proof to sell their supplements. Companies that make supplements must make sure they're safe. Dietary supplements are not medicines. Initially, caffeine raises your metabolic rate through thermogenesis, yet studies reveal complex interactions with weight management. Research reveals that supplementation for 12 weeks can reduce body fat mass significantly in overweight individuals with BMI between 25 to 35 kg/m². If you’re looking for supplements that actually work for weight loss, you’re in the right place. According to a comprehensive review of 111 clinical trials with 6,171 participants, certain natural supplements for weight loss can actually help you shed pounds. However, whether this translates in sustained weight loss is still unclear and the quality of evidence supporting its application for obesity treatment is low. The body of evidence shows that Capsaicinoids and capsaicin are effective in promoting a negative energy balance short term via thermogenesis enhancement and energy intake reduction, especially in overweight and obese subjects. A recent metanalysis showed that ingestion of capsaicin or capsinoids leads to increased energy expenditure (58.56 kcal/day) and decreased respiratory quotient, indicating enhanced fat oxidation. In a 2014, a systematic review and metanalysis analyzing capsaicin and capsaicinoids effect on weight management, capsaicinoids consumption before meals resulted in a significant reduction in ad libitum energy intake (74 kcaL/meal) with significantly higher reduction for dosages over 2 mg . Most trials showed a beneficial effect of both capsaicinoids and capsinoids on energy expenditure, with a small increase in oxygen consumption, body temperature, and metabolic rate (about 50 kcal/day). Following full-text review and identification of studies, the team modified the protocol to include RCTs rather than observational trials.For a deep dive into protein options, check out our guide on best protein powders.The composition of gut microbiota is highly correlated with obesity and related diseases such as T2D 33,34,35, as intestinal bacteria have been shown to affect fat storage, blood glucose balance, and appetite hormones 36,37.Certain supplements, however, may help counteract this insulin resistance.Nevertheless, several studies reported no significant body weight loss after Cr supplementation compared to placebo or even reported significant weight gain.Sometimes, a supplement such as berberine is effective until it isn’t. Not to mention, fat burners aren’t a magic pill, let’s be honest. There’s no such thing as a best fat burner for men or women (they’re not gender-specific). The opinions and articles on this site are not intended for use as diagnosis, prevention, and/or treatment of health problems. So, our team of personal trainers and athletes wanted to offer the safest products possible. That’s why we recommend everyone speak with a medical professional before trying a fat burner, especially if you have any pre-existing conditions. While most over-the-counter fat burners probably won’t cause any harm, different athletes have different bodies. If you prefer to take your fat burner when you wake up in the morning, any product on this list should be just fine. When you are looking at these ingredients, you’ll also want to make sure to stay away from proprietary blends. But practicing healthy lifestyle habits may help limit weight gain. Have you tried diet and exercise but haven't been able to lose enough weight? Some slim teas even have harmful hidden ingredients, and like all supplements, they aren’t regulated by the FDA. It’s the little (and consistent) things that add up to success — whether it’s through supplements, stress management, or movement. Maybe you tried a juice cleanse, diet tea, or supplement that literally said it would “melt fat”. It’s always a good idea to consult with your doctor before starting a new fat burner pill cycle, and if you do start to experience serious side effects, stop using the product immediately. While the FDA takes measures to ban dangerous substances from fat burners, they may still cause some unwelcome side effects. “The research has shown that green tea extract may offer many benefits for the average healthy adult,” according to Chelsea Rae Bourgeois, RDN, who rates this formula at 4 out of 5. Green tea may help increase your total fat burn while you’re exercising and recovering but different studies show different results. This supplement is an unflavored powder, making it easy to mix with other supplements in a smoothie or your best shaker bottle. But if you find yourself consistently craving calorie-dense, processed foods, you may want to reevaluate your daily diet and potentially add some nutritious calories to your meals. Although we know it’s a common word, we don’t love to consider eating certain foods as ‘cheating.’ With that said, if you’re going to indulge or stray from your meal plan, enjoy it. If you eat well and train a few times a week, however, a fat burner may help expedite the process a little bit. “A lack of sleep or continued bad quality sleep can disrupt your hunger hormones and lead to weight gain.” However, if you prefer to work out late at night, you may want to opt for a fat burner that doesn’t contain any stimulants. Get Healthier... Stay Healthier! With prescription medications, a healthcare professional can weigh all factors affecting the patient’s lifestyle and BMI and monitor progress and side effects. The only over-the-counter medicine for weight loss currently approved by the FDA is Alli (orlistat). AOMs may counter the effects of metabolic adaptation and prevent weight regain. Medicare does not cover weight loss drugs. If you’d rather not add yet another supplement to your regimen, you can also find carnitine in more comprehensive formulations, such as Legion Recharge, a popular post-workout supplement. Momentous L-Carnitine provides about 500mg of carnitine per serving with no added fillers or ingredients. “It’s drinkable and I can finish the whole serving but I can still tell it’s a greens powder. “Compared to other options on the market, it’s a cost-effective formula,” says Bourgeois.Show Me the Greens is only available in one flavor, Green Apple Sorbet. Show Me the Greens is one of the more budget-friendly greens powders on the market and your purchase comes with a 30-day money-back guarantee. Recent clinical trials (2024–2026) have examined the efficacy of various weight loss supplements. Understanding the science behind weight loss supplements is key to making informed choices. These 8 weight loss supplements represent the most promising options for 2026, each with unique strengths. If you like your weight loss supplements in a fun, easy format, these gummies could be for you. These pectin-based gummies are a convenient and tasty entry in the world of weight loss supplements. Finally, you'll want to be sure that the supplements you choose are safe to take. Make sure the supplements you choose fit comfortably within your budget. If you have a significant amount of weight to lose, you may want to continue using a supplement for months or even years. If other supplements aren't third-party tested, you can check on their website to see if they have a rigorous in-house testing protocol or if they share their lab reports publicly. Although she did use prescribed medication, she emphasized that it was part of a holistic approach, including diet and exercise.HCA, extracted from the rind of the fruit, is an organic acid which has been proved to be a potent competitive inhibitor of adenosine triphosphate-citrate lyase , therefore reducing the availability of acetyl-coenzyme A for fatty acids and cholesterol synthesis .Caffeine is a natural metabolism booster, helping the body to burn more calories.Carb blocker supplements can reduce caloric intake by helping prevent the breakdown and absorption of carbohydrates.Evidence-based compounds that burn fat and suppress appetite.The most frequently reported adverse effect of guar gum supplementation was GI discomfort, such as flatulence, diarrhoea, and abdominal pain, occasionally leading to drop-out from studies . If you prefer to work out late at night, you may want to stay away from fat burners with stimulants (like caffeine) that could affect your sleep if you take them too late in the day. These blends that may be listed on products do not give you a full look into the ingredients you’re getting and their dosages, so it’s best to steer clear altogether. Though many fat burners include ingredients that touch all three of these methods, most products lean more heavily toward one of the three. To assist with that, many of the best fat burners for active women feature caffeine, which boosts energy and endurance so you can go harder during your gym time. That way, your body is more likely to use the stored fat during exercise. Probiotics for Weight Management Also, like any supplement, there may be side effects like digestive issues, headaches, trouble sleeping, and higher blood pressure.(7) However, this is probably most beneficial for people with larger amounts of body fat or those with diagnosed obesity, according to Jillian Kubala, RDN.Timing supplements correctly can enhance their impact.PhenQ is one of the best w͏eight lo͏ss suppl͏ements for accelerating metabolism and enhancing fat burning, but reviews on the supplement’s efficacy are mixed.This supplement contains natural ingredients, such as capsimax powder, chromium picolinate, caffeine, nopal, and L-carnitine furmarate. (35) Other studies suggest they may help reduce abdominal fat when used as part of a weight loss regimen. Regarding weight loss, omega-3 fatty acids may enhance fat burning, boost metabolism, and improve satiety to help curb cravings. The added vitamin E, a powerful antioxidant, helps combat inflammation, which may support improved metabolic health and weight loss efforts. If your weight loss journey includes increased physical activity, it’s important to be mindful of your bone and cardiovascular health.” (28) Below are a few benefits that can come from high-quality fat burners for men. (11) “It’s always good practice to speak to your personal doctor before beginning a green tea supplement, just to ensure you’re fit for regular consumption.” You can purchase a 60-serving container for $32, which equates to roughly $0.53 per dose (or roughly $1.59 per day if taking three servings). If you’d rather take a powdered supplement, you could try 1st Phorm L-Carnitine as an alternative. “Acetyl-L carnitine is a naturally-occurring amino acid that has been linked to energy production and brain function — two important factors in weight loss,” says Bourgeois. “Show Me the Greens Powder aims to support a healthy gut.” That support comes from the fiber-rich prebiotic blend, which nourishes beneficial gut bacteria. Efforts to lose weight should not come with unwanted side effects, so if you’re sensitive to caffeine, you might search for a different pre-workout.” “Improved blood flow can help you make the most of your workouts, supporting weight loss efforts. Focus on products that align with your specific needs, whether it’s appetite suppression, belly fat reduction, or increased energy levels. By following these precautions, you can minimise risks and enjoy the benefits of weight loss supplements confidently. These benefits make weight loss supplements a valuable addition to your regimen, especially when combined with a balanced lifestyle. Are you tired of sifting through endless weight loss supplements, unsure which ones actually work? Deliciously apple-flavoured, gluten-free, and easy to take daily, these gummies provide a convenient way to support healthy weight management and vitality. Animal Cuts Thermogenic Fat Burner is a reliable choice for anyone looking for weight loss pills that work fast, support metabolism, and help manage appetite. Mitolyn is designed to support natural energy production and weight management by targeting cellular health. This is why third-party testing is so important, especially for weight loss supplements, which have a history of mislabeling93. He uses his background in clinical nutrition to dissect research and help individuals meet their health and fitness goals. Daniel Preiato is a registered dietitian who specializes in sports nutrition and nutrition education. These work to boost thermogenesis, or the process through which calories are burned in the body. It also feeds the probiotic bacteria in your microbiome, improving your gut health and helping reduce inflammation. It also burns stored fat, blocks fat production, and improves mood and energy levels. But we love it because it combines a lot of benefits into one bottle, and their formula packs a caffeine punch as well, making a great habit to start your day. LeanBean is the trendiest natural weight loss pill for women. Fortunately for you, we’ve looked at the best weight loss pills on the market and ranked them according to how effective they’ll be for you. If you are considering weight loss supplements, it’s natural to have questions about safety, effectiveness, and best practices. Nutrition, regular physical activity, and behavioral interventions enhance the effects of weight loss supplements. The FDA has issued warnings about hidden drug ingredients in some weight loss supplements, highlighting the need for careful product selection. Codeage GLP-Advantage+ is at the forefront of advanced weight loss supplements, targeting the GLP-1 pathway for appetite and metabolic regulation. Saxenda is a once daily, injectable GLP-1 receptor agonist that’s approved for weight loss. Adults living with Type 2 diabetes saw about 14% weight loss along with improvements in blood sugar readings. After about 68 weeks (15 months), adults without diabetes lost about 20% of their body weight on average. Traditional GLP-1 medications were effective, but resulted in less weight loss overall. ͏For t͏his reason,͏ t͏hey shoul͏d be͏ us͏ed ͏as part͏ ͏of a͏ compre͏hensive a͏pproach t͏hat inc͏ludes a͏ heal͏thy d͏iet ͏and exercise͏. The best appetite suppressants work by curbing hunger signals in the brain to reduce caloric intake. For͏ ͏example, ͏green coffee͏ be͏an extract͏ c͏an improve͏ fa͏tty a͏cid trans͏port an͏d increases the rate at which energy is burned.͏ T͏he be͏st fa͏t bu͏rners ͏can incre͏ase metab͏olism an͏d boost thermogenesis to͏ enhanc͏e c͏alorie ͏and fat͏ los͏s. Do you feel like you’re not losing weight, even when you limit your caloric intake? Supplements like probiotics, protein powders, and multivitamins can help give you the energy and focus to power through a slight calorie deficit and workout regimen. A safe and healthy goal is losing 1-2 pounds per week. In reality, sustainable weight loss takes time and effort. Setting specific goals can keep you motivated and help you choose the right supplements. Unfortunately, protein in the form of solid foods can be expensive, time-consuming to prepare, and difficult to eat enough of consistently. Protein of all types, including not only whey protein but also plant-based protein, is also renowned for its ability to boost your feelings of fullness. “Muscle mass is metabolically active, which means it burns calories and plays a role in keeping the metabolism from slowing down,” says Moody. Yes, it's a little more expensive than other protein powders but you get what you pay for. Our dietitian-verified guide to the best multivitamins for men is where to start. Notably, one double-blind study showed that 6 mg daily capsaicin intake for 12 weeks led to significant abdominal fat reduction. Studies demonstrate that this compound maintains lipid homeostasis by regulating fat generation and transfer. Primarily, capsaicin works by promoting calorie expenditure and fat oxidation. Discovered in chili peppers, capsaicin represents a potent compound that affects metabolism through multiple pathways. Occasionally, mild side effects like heartburn might occur, yet doses up to 2g daily remain generally safe. Res Prebeet Energy Prebiotic is a drink mix that's designed to support digestive health, particularly in people taking GLP-1 medications. Momentous supplements are third-party tested to ensure quality and safety, and you can view test results for each product on the Momentous website. Consuming more than 400 milligrams (mg) per day (the equivalent of about four cups of coffee) may cause unpleasant side effects like diarrhea, anxiety, and headaches. Clinical evidence suggests ALA works best when combined with lifestyle modifications, making it a valuable addition to comprehensive weight management strategies. A significant trial demonstrated that 1800mg daily led to a 2.1% reduction in body weight. Recognized for its dual solubility in both fat and water, alpha-lipoic acid (ALA) functions as a unique antioxidant compound that supports metabolic processes. Research shows that capsaicin regulates lipid metabolism by stimulating fat breakdown and inhibiting fat synthesis. When necessary, we recommend consulting a trans-affirming healthcare professional to make sure you’re taking the best care of your body as possible. Different bodies have different needs, so whether you were assigned female or male at birth, we want you to choose which supplements, equipment, and fitness regimens are best for you right now. To provide assistance, we’ve tested and researched a range of the best fat burners for men with the help of expert-driven insight and foundational protocols established through our supplement testing methodology. Thermogenic formulas often combine ingredients like caffeine, green tea, and L-tyrosine to increase calorie burn. Weight loss supplements function by influencing various physiological processes. Always consider your personal goals, lifestyle, and consult with a healthcare provider before starting a new supplement. It works by blocking about 25 percent of fat intake, making it a trusted choice for clinically validated support. What truly sets Oneleaf apart is its focus on long-term change, making healthy choices automatic. Limited clinical evidence supports a potential beneficial effect of GCBE for short-term (87], and CGA exhibits anti-diabetic and anti-lipidemic properties . These results appear most supportive of GCBE in blood glucose while the effect of GCBE on BP and lipids is promising but requires further investigation. In that meta-analysis, the hypertensive subjects were diverse and included overweight/obese and those with metabolic syndrome. Green tea Regardless of how you choose to lose weight, whether using prescription medication or a weight loss behavior modification program, eating fewer calories is part of the equation. Berberine supplements may cause diarrhea, constipation, gas and upset stomach. The evidence regarding berberine and weight loss is far from conclusive. This fat burner was designed to help MMA fighters melt fat before their fights. 3) Triggering appetite reduction that results in more feelings of satiation while eating less 2) Decreasing nutrient absorption, especially fat, so total calorie intake drops 1) Revving up the metabolism, so you burn more calories Choline supplementation has been explored in randomized, double-blind, placebo-controlled trials on lipid profiles with no effect seen with 400 mg/day choline in T2DM subjects or with 1 g choline/day in 42 healthy postmenopausal women . Reduced BF accounted for the majority of the weight loss, mainly due to the effect of choline on fat metabolism. Based on its known lipotropic activity, some clinical studies have explored its effect on fat deposition and weight loss. Most of these products appear to include choline as a vitamin for nutrition purposes, but some claim that the added choline helps with fat metabolism and increases energy. A search of the Mintel GNPD database revealed some supplements with weight management claims that contain choline, whereby a majority were in the form of choline bitartrate, with a handful as citrate salts, phosphatidylcholine, and alpha-GPC. For BodyNutrition‘s #1 natural weight loss supplement recommendation, click here.There are, however, some supplements that can aid you on your weight-loss journey.It’s got 5-HTP, caralluma fimbriata, and forskolin, which all may help increase your metabolism, suppress your appetite, and burn body fat.We'll explore the top supplements that can support various aspects of health, from cardiovascular function and cognitive performance to immune resilience and joint mobility.Weight-loss supplements are not a substitute for a balanced diet and regular exercise.Show Me the Greens is one of the more budget-friendly greens powders on the market and your purchase comes with a 30-day money-back guarantee.It can make weight loss and weight management more difficult (28, 29, 30).Thermogenic supplements aim to increase body heat production, leading to a higher calorie burn.(8) “While these studies can be promising, I still rate the formulation at 2.5 out of 5 given the lack of confirmed information.” However, among the thirteen studies selected, most had caffeine being administered in association with other compounds, such as ephedrine or green tea, or in the form of coffee beverage, making the effects of caffeine from CGA and other elements indistinguishable. Scientific studies often lack an adequate differentiation between the effects of its single compounds, whose most important are caffeine, chlorogenic acid (CGA), diterpenes, and trigonelline. A systematic review and metanalysis of 14 RCTs examined the effect of WP, with or without resistance exercise, on body weight and body composition. An overall significant reduction in body weight (mean −1.56 Kg) body fat percentage and waist circumference were observed, with no change in BMI and waist-to-hip ratio . Second, you will most likely have rebound weight gain once you stop taking those supplements.For example, studies on berberine phytosome capsules demonstrate improved absorption and metabolic outcomes over standard formulations.One serving includes 300 milligrams of green tea leaf extract, 250 milligrams of ForsLean, 125 milligrams of natural caffeine, and 50 milligrams of Capsimax.For example, Denise highlights its success in suppressing appetite and its lack of adverse effects .With the guidance of your healthcare provider, these weight loss supplements for women can help you reduce body fat, lose weight, and build lean muscle mass—helping you achieve the health and vitality you desire in the new year. For those who want a thermogenic fat burner, we recommend Jacked Factory BURN-XT. We score the servings at 3 out of 5 and recommend something like Legion Phoenix Fat Burner Without Stimulants if you need a more convenient, single-serving supplement routine. Speaking of the servings, while we like the two-capsule serving size, it’s recommended that you consume two servings daily for optimal results. Bob seconds this by saying, “I don’t know of any supplements that alleviate menopausal symptoms and promote weight loss in a significant way.” His suggestion? As a general rule, we don’t recommend fat burners, appetite suppressants, or off-label use of prescription medications for weight loss. “Weight loss supplements for PCOS should target reversing insulin resistance,” Bob begins, “as this is what typically causes the weight gain.” One of his suggestions is fish oil supplements, particularly omega-3 fatty acids. This mineral carries and delivers oxygen to cells all over the body, and if your exercising muscles can’t get enough oxygen, your exercise performance will suffer, which may impact your weight loss results. Such symptoms naturally impact your day-to-day choices; it’s hard to make healthy choices when you don’t feel good. If you’re interested in more budget-friendly fat burners, consider Transparent Labs Body Recomp or Jacked Factory BURN-XT. We also appreciate that the directions for Legion Phoenix Fat Burner Without Stimulants call for just a single serving per day, ideally taken first thing in the morning with an accompanying meal. This formulation is available with or without caffeine, but we’re focusing on the caffeine-free variety for this particular review. Legion's Phoenix comes with an extra absorbable form of synephrine and a high dosage of EGCG to promote its fat-burning properties. “This now has the option of coming with a breath sensor to measure metabolism,” Puttuck says. All members get coaching from a goal specialist, dietitian and personal trainer, per its website. News and World Report in 2025, the program centers on balanced, premade meals and controls calories and hunger by eating frequently throughout the day, according to its website. She emphasizes the on-boarding questionnaire, which allows the user to personalize their program and guiding them with education so they learn there’s a reason to choose certain foods over others based on the health benefits. “TOPS clubs offer an inexpensive and easily accessible support system via virtual and in-person meetings,” Mok says. In addition to working with pro athletes, Destini has ghostwritten four weight loss and wellness cookbooks. Here are a few tips to help you get ready, and what to expect from your healthcare professional. See your family or primary healthcare professional first if you have symptoms that worry you. Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition. Weight loss However, you do need to take two doses per day, so we score the dosage convenience at 3 out of 5. We also like that the bottle provides supplement facts for one- and two-capsule servings. You also get 225 milligrams of green tea leaf extract, which may help promote your weight-loss journey and control blood sugar levels. That said, these same ingredients may benefit athletes of any gender. Overreliance on stimulants can also hinder long-term weight management efforts. Avoid products containing unknown or potentially harmful ingredients. The effectiveness of a supplement hinges on the correct dosage of its ingredients. Let's explore these options together and empower you to make informed choices on your weight loss journey. A truly effective supplement should complement your overall health and wellness goals, not compromise them. If you have a body mass index in the obese range, you may also want to consult an obesity medicine physician about prescription medications or surgical options. To truly lose fat and keep it off, you need to eat at a modest calorie deficit, following an eating plan that you can feasibly stick to for life. Losing weight can be challenging, especially if you are trying to do it quickly. It’s also important to follow the instructions on the supplement packaging and to not exceed the recommended daily dose, unless a doctor has recommended it. With a focus on one key ingredient, this supplement is perfect for those looking to simplify their supplement routine. The inclusion of added sugars might not align with everyone's dietary preferences, particularly for those following low-sugar diets. The gummy format and transparent labelling are definite plus points, making it accessible for those seeking a hassle-free supplement. While the 30-day money-back guarantee provides some reassurance, it's essential to weigh the potential benefits against these factors. Pair L-Carnitine with regular exercise for better results. If considering this option, look for products that are TGA-listed and come from trusted, transparent brands. Increasing soluble fibre by just 10 grams daily has been linked to a 3.7% lower risk of belly fat accumulation. Learn more about the factors that influence it in our guide on metabolic health in Australia. Carb blockers inhibit enzymes that break down carbohydrates, reducing the carbs absorbed by your body. Appetite suppressants help reduce your hunger, making it easier to stick to a calorie-controlled diet. Some ingredients, like synephrine found in bitter orange, may negatively impact individuals with heart conditions. Of the studies included in four recent meta-analyses on GCBE and cardiometabolic outcomes 78,79,80,81, only seven assessed adverse events, and of these, two reported some undesirable side effects during the GCBE or CGA intervention. CGA has diverse bioactions, including antioxidant, anti-inflammatory, glucose and lipid metabolism regulatory, and cardiovascular protective activities, which are considered the principal mechanisms underlying GCBE effects . Undesirable effects of GTE consumption reported in clinical trials are largely GI-related tolerance issues; however, hepatotoxicity concerns have led to a proposed UL of 300 mg/day of purified EGCG. Current evidence suggests that GTE may be beneficial for weight management, glucose regulation, and reducing TC and LDL-C as well as BP in people who are overweight or obese. Thus, the overall evidence supports the benefits of green tea/GTE on BP in the general population and overweight/obese individuals at increased risk for CVD. Dietitian Reveals 7 Simple Strategies to Help Your Body Absorb More Nutrients From Food Here are some common side effects or risks with some of the supplements we’ve recommended. This is not to say that all weight loss products are inherently bad. With input from registered dietitians, we chose our recommended supplements by focusing on nutrients with a proven history of efficacy and safety. Because of this, there’s not really a supplement that addresses weight loss and menopause at the same time. However, this doesn’t aid in weight loss or fat-burning much at all. The green tea/GTE amount included in these studies ranged from 80–3000 mg catechins/day, and the reduction in TC and LDL-C appears to be independent of dose or duration. The reduction in fasting blood glucose (FBG) following green tea/GTE has been supported by several meta-analyses, although the effective dose and supplementation duration are unclear 56,57,58,59,60,61. A meta-analysis was published with 11 studies in T2DM patients, in which 10 used GTE and one used brewed green tea at amounts ranging from 400–10,000 mg/day and durations from 8–12 weeks . Jacked Factory Growth Surge Review ( : The Ultimate Post-Workout Supplement? Animal studies suggest CGA is of low toxicity with an LD50 of 100 mg/kg (7 g for a 70 kg adult) 76,77. No authoritative reports were identified specifically for GCBE; however, humans have a high metabolic capacity for CGA with no evidence of saturation of metabolic pathways for doses ≤2 g/day . The daily intake of CGA among coffee drinkers has been estimated to be 100–300 mg/day for medium drinkers and ≤600 mg/day for heavy drinkers . However, an earlier meta-analysis showed green tea/GTE remained effective in improving SBP and DBP in overweight and obese people but to a smaller extent . “RDNs’ nutrition plans involve a comprehensive assessment of a person’s health, including medical history, anthropometrics, blood and lab test results, physical signs and symptoms, diet history, and food and health care accessibility, to meet individuals where they are at.” Research shows that the most effective programs come with counselors who can help you build new diet and exercise habits. “It’s incredibly important for weight loss programs to include cultural foods as this directly impacts a person’s adherence, sustainability and overall wellbeing,” Mok says. Also, before you try a fat burner, it’s best to confirm with your physician that they’re safe for your body. The FDA doesn’t regulate fat burners in the same way that it does other supplements. If you take a fat burner with caffeine too late in the day, it could potentially mess with your sleep. It’s a complicated series of mechanisms that govern how your body gains or loses weight. If you are vegetarian or vegan, choosing over the counter or medications for weight loss can be difficult as gelatin is a common ingredient in pill capsules. Weight loss supplements used alone provide nothing more than a Band-Aid to a growing infection. 11 If you recall, this was one of the ingredients originally in Hydroxycut products prior to their ban. A 2012 review of twenty clinical trials investigated the effects of capsaicinoids and capsinoids on energy expenditure, lipid oxidation and appetite regulation, in both short term (meal tests) and long-term interventions (up to four months). Other studies have demonstrated that capsaicin and capsaicinoids are able to induce thermogenesis, activating UCP-1 and 2 , increase fat oxidation, SNS activity, and energy expenditure via GI TRPV1 activation and promote SIRT-1 expression, inducing browning of white adipose tissue . Here, we provide more details concerning natural compounds proven to exert an effect on energy expenditure, although it should be kept in mind that most mechanistic evidence is on rodent models, and the weight loss effect only was proven in human subjects. However, studies on primates and human subjects quickly proved that the physiology of energy metabolism is very different across species, and the same effect could not be replicated in men or women. All weight loss medications work best in the context of a healthy eating plan and exercise.Replenish post-workout with this fruity Ninja Creami packed with protein,...Other side effects not listed may also occur in some patients.Conjugated Linoleic Acid (CLA) is a fatty acid found in animal products that may help with weight management.Sadly, the amount commonly present in supplements is too low to be effective and when larger amounts we studied, there was no significant change.The best supplements for weight loss 2025 are practical, science-supported dietary supplements designed to help your healthy choices stick.Wrecked contains 125 milligrams of caffeine anhydrous, 50 milligrams of slow-release di-caffeine malate, 1,750 milligrams of beta-alanine, and 1,500 milligrams of betaine anhydrous, among other potent ingredients. PhenQ contains ingredients, like the previously mentioned capsaicinoids, that reduce your body's ability to store excess fat cells and chromium picolinate to improve insulin sensitivity and curb your sweet tooth. If you're looking for a solid appetite suppressant to aid in your weight loss goals, we recommend PhenQ. By combining the power of probiotics and essential nutrients, Hey Nutrition has created a product that supports your overall well-being while helping you achieve your weight loss goals. This comprehensive formula goes beyond mere supplementation, offering a holistic approach to weight management. Choosing the right weight loss supplement can feel overwhelming. Study duration ranged from 30 days to 24 weeks and the number of participants in each arm ranged from 12 to 62 subjects. Funding sources were not revealed for three studies (43%); the remaining were funded by industry and local universities. None of these studies fulfilled low risk of bias across each category. (6) While the body can be fine without carnitine supplementation, added dosages may be linked to improved fat metabolism and fat mass maintenance. This fat burner combines ingredients to help potentially suppress appetite, boost energy, and increase your total calorie burn. Others among our top-ranked weight loss pills are also effective, but Leanbean is our bet for the best over the counter diet pill for belly fat. We’re confident that the ten remaining supplements represent the top weight loss pills on the market right now. Two of the prime suspects here were bitter orange and synephrine, which are chemical analogues of ephedra, a weight loss supplement that was pulled from the market after side effects including heart arrhythmias occurred. For a balanced approach to weight management, consider incorporating exercise into your routine. Patience is essential, as no supplement alone delivers rapid, magic weight loss. High-quality protein powders support muscle maintenance and appetite control. Hydroxycut is one of the most well-known weight loss supplements, featuring ingredients like caffeine, green coffee bean extract, and Yohimbe extract. While a balanced diet and regular exercise are crucial for weight loss, supplements can provide additional support to help you reach your goals faster. These supplements complement a balanced diet and exercise routine, supporting significant weight loss. Several strategies have been proposed for the treatment of weight excess and its detrimental consequences, ranging from dietary regimens 9,10,11,12,13,14,15, to pharmacological treatments 16,17, physical exercise , and psychological approaches . Further studies will be needed to confirm the weight loss and metabolic improvement that may be obtained through the use of the proposed combination. Weight loss supplements are not a substitute for a balanced diet and physical activity. Check for a Natural Product Number (NPN) and consult your healthcare provider before using any supplements. By making informed decisions, you can enhance your weight loss efforts while protecting your overall health and well-being. Third-party tested and clearly dosed, Transparent Labs LEAN has a huge variety of ingredients for endurance, power, alertness, and focus. If you’re in the market for a budget protein supp, we recommend offerings from Nutricost and Jacked Factory. “I tried the chocolate flavor and it was kind of like drinking a protein Yoo-hoo,” they say. Genius makes a name for itself with innovative and cutting-edge supplements that incorporate new and promising herbal extracts. It’s a solid choice to accelerate your weight loss. Transparent Lab’s fat burner is a no-nonsense thermogenic supplement. A balanced, whole food-based multivitamin can help ensure you meet the recommended daily allowance (RDA) of so-called “essential” vitamins and minerals, says registered dietitian Destini Moody. A fundamental truth of losing weight is that your calorie intake must be less than the amount of calories you burn. The Ritual Essential for Men Multivitamin 18+ is a well reviewed multivitamin with quality ingredients. But side effects aside, those pills must have still worked, right? The reason why is no secret to anyone who has ever taken a fat-loss product and instantly regretted it. And that being said, even the best fat burners aren’t a necessary supplement for weight loss — they don’t have a ton of research, and some even include some sketchy ingredients. “Presently, I’ve had limited individuals take this weight loss pill; however, I’ve encouraged fiber supplements similar to Plenity’s appetite-reducing action. When it comes to losing weight, a healthy diet and exercise plan is the holy grail. Joint supplementation of calcium and vitamin D is proposed to regulate adipocyte lipid metabolism and triglyceride storage, improving metabolic health and reducing body weight (45,46). The quality of the research studies included in these reviews is an important factor as well, and randomized clinical trials are the preferred evidence for establishing cause-and-effect relationships 13,14. Over the past several decades, much work has been directed on basing health and nutrition policy and recommendations on scientific evidence over expert opinions. Of these, caffeine, GTE (specifically epigallocatechin gallate EGCG), and choline have recommended intake limits, which appear not to be exceeded when used according to manufacturers’ instructions. Advertising revenue supports our not-for-profit mission. Mayo Clinic does not endorse companies or products. Unfortunately, much of the Western world doesn’t eat enough of these foods, making supplements extremely popular. You can get all these from whole foods like beans and legumes, fruits and veggies, nuts and seeds, plant or animal proteins, fatty fish, etc. You might get energy, but you’re also likely running to the bathroom more or are at serious risk for other health consequences. Countless supplements really aren’t needed, and most aren’t even mildly helpful. These small things matter more than you think — and weight loss is all about small habits that slowly lead to long-lasting results. But the rise in popularity of sea salt in recent years means people are getting less iodine, a reason to consider supplementation. Iodized table salt is the most common dietary source of iodine in the United States. Your body uses the trace mineral and antioxidant iodine21 in many ways, but the big ones are to synthesize the thyroid hormones T3 (triiodothyronine) and T4 (thyroxine). Choose Mitolyn today and take the next step toward your wellness and weight loss goals. Ready to support your metabolism and energy levels naturally? Additionally, it’s common to regain weight when you stop taking a diet pill. For most ingredients in weight loss pills, there isn’t enough long-term evidence to definitively say whether they are safe for consumption. Sixteen studies (24%) were categorized as high quality, of which six demonstrated significant weight loss ranging from 0.7 to 3 kg (see Tables S17A–D). Pyruvate has been proposed to aid with lipid metabolism through reversible conversion to phosphoenolpyruvate and to increase glucose uptake by skeletal muscles, providing a potential for weight loss (117). Phenylpropylamine (PPA) is similar in structure to amphetamine and ephedrine and may act as an appetite suppressant to induce weight loss, believing to act via the alpha-1 adrenergic receptor (115). Three studies reported significant weight loss compared to placebo, while three did not report such statistical changes (see Table S14A–D). A research study to see how well CagriSema helps people with excess body weight lose weight (REDEFINE 1). Data shows nearly 19% weight loss in people with overweight or obesity in Boehringer Ingelheim and Zealand Pharma Phase II trial with survodutide (BI ). Structure pill leads to competitive weight loss in obesity study. Your healthcare professional can tell you if weight-loss medication is right for you. She has extensive experience with dietary supplements and nutrition in particular. With help from your health care team, you can take steps to manage nonalcoholic fatty liver disease. Typically, losing 10% of your body weight or more is recommended. Losing weight may improve other health conditions that can lead to MASLD.