Studies from Novo Nordisk (the company that makes it) show people losing 15-20% of their body weight. GLP-1 (glucagon-like peptide-1) receptor agonists are medications that copy what your body naturally does. This medication works by mimicking a hormone in your body that helps control blood sugar and appetite. Yes, even if your doctor prescribes it to treat diabetes, Ozempic can also benefit weight loss efforts as a secondary perk. The weight of being a Hollywood star can take a toll on a person’s weight. “But it’s also because I had a chef for our two years in Los Angeles, and I don’t have a chef now.” She further revealed that her current weight is 173. Sign up for health tips, exclusive promotions, and more. Fortunately, there are natural semaglutide alternatives. The popularity and efficacy of the drugs prompted legislators in June to update a measure unsuccessfully introduced in 2014 legalizing Medicare coverage for weight loss alone. Unfortunately, Medicare is prohibited by law to cover drugs prescribed specifically for weight loss. Purdue University will cover the drugs for employees with BMIs over 30, but requires employees to have lost at least 5% of their body weight after three months to continue coverage. As for other bias, it was also deemed questionable since all trials had confounding factors such as diet and exercise adherence that may have significantly affected the magnitude of weight loss. All were adults ≥18 years old with a BMI of ≥30 kg/m2 or ≥27 kg/m2 with at least 1 treated or untreated weight-related comorbidity without diabetes. The search strategy was “semaglutide” AND “obesity.” No filter was used. The study also aimed to determine the risk of gastrointestinal adverse events, risk for discontinuation and serious adverse events after treatment with semaglutide. Dermatologists and aesthetic doctors say patients are increasingly raising concerns about how certain parts of their appearance have changed since beginning treatment. However, those sudden changes in body composition can have visible effects elsewhere, particularly in areas where skin structure is more delicate. Weight loss injections have rapidly shifted from niche medical treatments to mainstream conversation, but the term ‘Ozempic neck’ is starting to become part of discussions more often, too. NIDDK translates and disseminates research findings to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Off-label use refers to the prescription of a drug for a purpose other than its stated FDA-approved use. Medical Daily is for informational purposes and should not be considered medical advice, diagnosis or treatment recommendation. “It’s going to take a little bit of time, maybe a whole month before someone starts to see any noticeable weight change, and the effects of it can be variable from person to person. Such insights transformed my perspective from viewing Ozempic as merely a weight-loss aid to appreciating it as a metabolic ally. Feel free to comment below or connect through forums dedicated to physician-supervised Ozempic treatments. From my experience and research, effective Ozempic therapy isn’t solely about the drug but also about the relationship between patient and clinician. People taking these medications also had reduced risks of suicidal thoughts, self-harm, bulimia and even psychotic disorders like schizophrenia, the study said. They then compared these findings to a control group of over one million individuals using other anti-diabetic drugs. Glucagon-like peptide-1 receptor agonists (also known as GLP-1s), including medications like Ozempic, Mounjaro and Zepbound, have gained popularity over the years. These people are paying $1000 a shot for it so those of us with diabetes cannot get the meds we need. Research consistently shows that social inequities and environment are key factors behind obesity disparities. “The fact that we know these medicines work in the brain and the pancreas and they’re so effective is proof that it’s a biological mechanism that’s out of whack.” Along with numbers on the scale, risks for diabetes, kidney and heart diseases, fatty liver disorders, and cancer all appear to go down. As weight increases, these communication pathways get damaged. The Future of Ozempic and Weight Loss People using Bydureon vs Ozempic specifically for weight loss usually see better results with Ozempic.In fact, Huntley said putting patients with prediabetes on GLP-1s for weight loss often prevented them from getting type 2 diabetes altogether.Australia’s Therapeutic Goods Administration (TGA) has approved Ozempic as safe to use, for the treatment of type 2 diabetes but it has not yet been approved for weight loss.But research suggests far more people might qualify, with the Centers for Medicare and Medicaid Services estimating roughly 28 million people on Medicaid are considered obese.The study of Wilding et al., used once weekly semaglutide injected subcutaneously starting at a dose of 0.25 mg and escalated every 4 weeks until the target dose of 2.4 mg was reached.An additional 8% body weight loss was seen over the 48 weeks (about 11 months) that followed.In recent years, medications like Mounjaro (tirzepatide) and Ozempic (semaglutide) have grabbed a lot of attention for their ability to support weight loss. In general, more weight loss may be seen with higher Ozempic doses. For some people, this dose isn’t enough to adequately manage their blood sugar levels. During clinical trials of people with Type 2 diabetes, those receiving the 0.5 mg Ozempic dose lost around 8 lbs over 30 weeks (7 months). It’s meant to help your body get used to the medication. During this time, you may notice some weight loss. This drug is part of a group of medicines called GLP-1 receptor agonists. That’s when researchers started studying how it works and why it helps some people drop pounds. ” Ozempic has become one of the most searched health-related topics online. ” and “Is it safe for someone who doesn’t have diabetes? Swiftie Loses 100 Pounds After Hitting ‘Rock Bottom’ at Taylor Swift Concert People have reported adverse events to the FDA after using "generic" versions of semaglutide.Dieting and exercise alone are not helpful for many people – medical interventions can be more effective than sheer willpower.Compared to newer drugs, there are years of safety data on the original GLP-1 medications.That doesn’t mean Ozempic is inherently unsafe for weight loss, but its safety and effectiveness for this purpose have not been specifically evaluated in UK regulatory approvals.Some concerns include that there has been limited research finalized on the effective, safe use of these medications in children .These effects can lead to weight loss, which can be an important part of managing diabetes.If a doctor recommends Ozempic specifically for weight loss, that is “off-label” use — prescribing it for a condition other than what the FDA has approved it to treat. Let’s embark on this journey together as we explore the complexities of Ozempic and weight loss. This has led to widespread speculation about when—if ever—Ozempic will receive FDA approval specifically for weight loss purposes. In this blog post, we’ll delve into the current status of Ozempic, its intended uses, and the nuances surrounding its weight loss potential. Semaglutide for weight loss should be used in addition to a reduced calorie diet and increased physical activity, the FDA says. Early side effects, dosage adjustments, and fluctuating motivation can test your resolve. Weight loss, especially when supported by a medication like Ozempic, rarely happens overnight. This evidence reinforces the clinician’s role in developing sustainable weight management plans tailored to individual trajectories. Resources like physician-prescribed Ozempic side effect management guides are invaluable for patients seeking to navigate these challenges effectively. This collaborative model of care significantly enhances treatment adherence and outcomes. An earlier trial funded by the company showed people with Type 2 diabetes lost up to 14% of their body weight with the injection at 36 weeks, while those who took the daily pill lost 10%. In a late-stage trial funded by the pharmaceutical company, people lost 20% of their body weight on average after taking the drug for a year and four months. Some people might tolerate amylin analogs better than GLP-1 drugs, or the new option could help people overcome a weight-loss plateau, Jay notes. Hundreds of medications are needed for the treatment of a chronic disease like obesity, says Dr. Ania Jastreboff, director of the Yale Obesity Research Center. What started with Ozempic has become a new era in weight-loss success with blockbuster GLP-1 drugs like Wegovy and Zepbound helping fight obesity. Until the supply/demand discrepancy is solved, those with chronic diseases such as type 2 diabetes, hyperglycemia, and moderate to severe obesity, should be prioritized in receiving Ozempic. Orforglipron, an oral small-molecule GLP-1 receptor agonist for obesity treatment. Wharton hopes both oral drugs will be available to consumers by 2026, though that depends how quickly they move through the FDA’s approval process. Those drugs have different molecular structures than orforglipron, Wharton says, which could explain why orforglipron didn’t cause the same trouble. And the researchers did not observe the liver toxicity that had plagued some earlier small molecule GLP-1 drugs. Throughout this story, we will focus on Ozempic, but note when there are differences with other drugs. “It’s like saying Kleenex, instead of tissue,” confirms endocrinologist Caroline K. Messer, MD. However, there are other drugs like Ozempic, which function slightly differently; among them, brand names like Mounjaro, Zepbound, and more. ELLE editors went on a deep dive to answer all of the most common questions about Ozempic and other similar drugs. Compounded semaglutide is often a more cost-effective solution for those seeking to lose weight without insurance coverage. If your insurance won’t cover Ozempic for weight loss, check to see if they’ll cover Wegovy instead. Sometimes, doctors can submit a prior authorization request to your insurance, explaining why Ozempic is necessary for your weight loss. At this time in 2024, there is no clear indication that Ozempic will gain widespread insurance coverage specifically for weight loss anytime soon. But, despite its popularity, insurance coverage for weight loss use remains murky. By exploring new formulations, combinations, and approaches, we can unlock the full potential of these medications and create a brighter future for millions of people struggling with weight loss. The widespread adoption of Ozempic and other weight loss medications could lead to a significant reduction in healthcare costs, improved quality of life, and a decreased risk of chronic diseases. This approval marked a significant milestone in the treatment of obesity, offering a new hope for millions of people struggling with weight loss. The SUSTAIN program showed that Ozempic not only reduced blood sugar levels but also led to significant weight loss in patients with type 2 diabetes. This approval was based on the results of the SUSTAIN clinical trial program, which demonstrated Ozempic’s ability to reduce blood sugar levels, body weight, and cardiovascular risk in patients with type 2 diabetes. Ozempic, also known by its generic name semaglutide, belongs to a class of medications called GLP-1 receptor agonists. Whether you’re dealing with weight-related health issues or simply exploring safe, medical fat loss aids, this guide will help clarify your options. In this article, we’ll break down how Ozempic works, its effectiveness for weight loss, possible side effects, and what you should consider before starting it. While originally developed to treat and control type 2 diabetes, it has gained global attention for its potential role in weight loss. It’s not a good weight loss measure if you’re really planning to keep something off,” he said. “It’s not a good idea for someone who hopes to keep it off because one thing that we know is when you stop the medication, whether it be a few months down the road or a year later, your weight will come back pretty rapidly. Dr. Thomas Su, a plastic surgeon, exclusively spoke with Us Weekly to address the worrying trend that caused shortages amid the strong demand for Ozempic, Wegovy and similar drugs. Join over 200k+ people taking control of their health. “Ultimately, people can’t really look at Ozempic as a short-term fix to lose weight,” Sowa says. “These medications are expensive,” Shah says. Also, these medications aren’t designed to be used in the short-term. If you have diabetes and already take a different medication, talk to your physician about acceptable (and safe) combinations of diabetes medication. They know your personal and family medical history and can guide you in the best treatment for your condition. Gastrointestinal issues are the most common complaint among people just starting semaglutide. But they’ve also revealed that participants tend to regain the weight lost when they stop taking semaglutide. We are offering primary medical obesity treatment with medications. Certain GLP-1 and GIP/GLP-1 receptor agonists are specifically approved to help certain people with and without diabetes manage their body weight. GLP-1s aren’t “miracle drugs,” but they are powerful tools for managing type 2 diabetes and obesity when used under proper medical guidance. Touted as game-changers for weight loss, drugs like Ozempic, Wegovy, Mounjaro and Zepbound are getting attention far beyond diabetes care. What you need to know about Ozempic and other drugs being used for weight loss Dr Yael Wolff Sagy, the study's co-lead author from Clalit Health Services in Tel-Aviv, Israel, said a "direct effect" of the injections was that they were found "to be 41% more effective at preventing obesity-related cancer". People in the semaglutide trial also experienced problems with gallstones. Tirzepatide - Mounjaro - is a dual-acting drug and also mimics the hormone GIP (glucose-dependent insulinotropic polypeptide). Both semaglutide and tirzepatide work by mimicking the hormone, GLP-1 (glucagon-like peptide one), to manage hunger and slow down digestion. But what are these drugs, how do they work - and what were they originally designed to do? "While reducing daily calorie intake and increasing daily calorie output are important for weight reduction, they do not go far enough in managing obesity. They fall short of influencing the pathways near the hypothalamus that regulate weight and appetite," Soleymani added. "More than half of the participants in Wegovy research trials achieved 15% weight loss and one third achieved 20% or greater," Soleymani said. Ozempic comes with potential side effects and adverse reactions. There are potential side effects, many gastrointestinal in nature, and your provider will be able to give you tips on how to reduce them. There is also a Patient Assistance Program for people who qualify, as well as a savings card that can reduce the price to $25 per prescription. Insurance plans may or may not cover Ozempic, so it’s important to connect with your insurance provider to see what your plan covers and what is needed to qualify for coverage. No longer hungry all the time The figures show that approximately 70% of American adults have obesity or are overweight. Clinical trials showed participants lost an average of 18% of their body weight over 72 weeks. The gentle, low-impact nature of walking also makes it ideal during the initial medication adjustment period when GI side effects might limit more intense exercise. Both medications carry rare but serious risks including pancreatitis, gallbladder disease, and a boxed warning for thyroid tumors based on animal studies. These symptoms typically appear during dose escalation periods and often subside as patients adjust to treatment. A 2022 cohort study found patients lost 5.9% of body weight at 3 months and 10.9% at 6 months when using semaglutide at clinical doses. Treatment with Ozempic also led to weight loss, which is considered beneficial in patients with diabetes. Studies showed that Ozempic is effective at lowering blood glucose levels and reducing the risk of health complications in patients with type 2 diabetes. A previous clinical trial, funded by Eli Lilly, found people lost 24% of their body weight after 48 weeks on the drug. In a phase 2 trial funded by the pharmaceutical company, people lost up to 20% of their body weight after taking the medication for almost a year. It may seem trivial, but Novo Nordisk manufacturing both is key to understanding the distinction between these medications. But what’s the difference between these two medications? Always contact your healthcare provider directly with any questions you may have regarding your health or specific medical advice. But how many people would have to be on the drug to really change it? But then you have your third of patients on the lower end of the scale who are only losing in the 10 percent range, and they'll say 90 percent of patients lost at least 10 percent of their weight. And there will be other drugs coming out at some point. There was nothing that caused dramatic weight loss. Which one you’re prescribed depends on your health history, risk factors, treatment goals, and other factors. Most people are more comfortable taking a pill than regularly injecting themselves, says Daniel Drucker, an endocrinologist at the University of Toronto, who previously consulted for Novo Nordisk.Ozempic is a once-weekly injectable medication FDA-approved for the treatment of type 2 diabetes.If you are looking for semaglutide for weight management, your insurance may be more willing to cover Wegovy.But other doctors say more long-term data is needed before committing patients to this drug for life.And a higher-dose version called Wegovy is available for weight loss in certain people with and without diabetes.Fortunately, there are natural semaglutide alternatives. If you have bariatric surgery and your obesity is in remission, does that mean you don't have the disease? I think obesity is with you forever. It's a change we’ve not had in obesity care since sleeve gastrectomy started in 2007. The other 98 percent basically had no effective treatment. Treatment for obesity is changing. Faced with limited access in Australia, some people who need the medication for diabetes can’t access it. TrimRx offers personalized weight loss programs, a free assessment quiz, and quick-access supplements to support your individual health goals. Consider potential side effects, the necessity for long-term use, and the importance of lifestyle changes for sustainable weight loss. While some healthcare providers may prescribe Ozempic off-label for weight loss, it is not its intended use, and it is essential to consult with a healthcare professional before doing so. Wegovy is a higher-dose version of semaglutide that is specifically approved by the FDA for chronic weight management. I can't tell you how many medical professionals I've heard say that. I have heard people talk about the quieting down or the food yearnings. Some people say that surgery turns that around for them. Now, there is a percentage of patients who are addicted. These medical breakthroughs and advances gave patients new hope in 2025 This collaborative model of care significantly enhances treatment adherence and outcomes.We also offer the necessary lab work to monitor your health throughout your weight loss journey.When it comes to medications, FDA approval is a key indicator of their intended use and safety.These anti-diabetic drugs can help with the hormonal changes and weight.A cosmetic surgeon has revealed the telltale signs of ‘Ozempic face’ and shared practical ways to avoid premature aging while losing weight.Never miss out on the latest innovative health care content tailored to you. It is acceptable to inject these in the same body area, but the shots should not be right next to each other. Keep track of where you give each shot to make sure you rotate body areas. Use a different body area each time you give yourself a shot. If you will be using semaglutide at home, your doctor will teach you how the injections will be given. Popular culture has contributed to this kind of misunderstanding that Ozempic is a weight loss medication. “These are remarkable medications and have been life-changing for many of my patients. Many GLP-1 medications are injectable, which can be uncomfortable for some patients. Semaglutide (which is prescribed under several brand names, including Ozempic) is a popular GLP-1 medication that has become well-known for lowering blood sugar and promoting weight loss. An increasing number of medications are becoming available to help patients control their weight. The active ingredient of Ozempic, semaglutide, is also the same active ingredient as Wegovy® which is FDA-approved for weight loss. Around 4.8% of people who switched to the pill from Wegovy discontinued treatment due to side effects, while 7.2% of those who switched to the oral drug from Zepbound did the same. The oral drug met the trial's main goal of demonstrating superior weight loss maintenance compared with a placebo, among people who previously experienced a plateau in their progress while taking the injections. The positive trial data suggests that the pill could be an effective treatment for patients to transition to if they want to preserve their weight loss but don't want to take weekly injections long term. Eli Lilly on Thursday said its closely watched obesity pill helped patients maintain the majority of their weight loss after they switched directly from taking the company's injection Zepbound and Novo Nordisk's rival shot Wegovy in a late-stage trial. In recent years, stronger versions of these GLP-1s were approved to help people with overweight and obesity. When Wegovy is taken for weight loss, the maintenance dose is 2.4 mg/week. The improved weight loss effectiveness of Wegovy vs. Ozempic is because it has a different dosing schedule and a higher maximum dose. If you’re looking for prescription weight loss injections in the UK, the primary alternative to Ozempic is Wegovy. This medication has the same active ingredient as Ozempic and is available on the NHS if you’re referred to a weight management programme like Oviva. You cannot be prescribed Ozempic if you’re not diabetic, and you should not take it for purposes other than the treatment of type 2 diabetes symptoms. Ozempic is also not always accessible for weight loss because of the high cost, and sometimes even higher demand. There is also concern that the medications may pass into breast milk, which could affect a breastfeeding child. Both medications carry rare but serious risks like pancreatitis, thyroid concerns, or kidney problems. People using Bydureon vs Ozempic specifically for weight loss usually see better results with Ozempic. This can increase the risk of adverse effects and may lead to the development of health complications. Some patients may experience more severe reactions, including pancreatitis, kidney injury, and even allergic reactions, which can necessitate discontinuation of the drug. Side effects such as nausea, vomiting, diarrhea, and abdominal pain are common in individuals taking Ozempic, especially when first starting the treatment. Given the concerns about safety, efficacy, and the possibility of misuse or over-prescription, the FDA may have opted to prioritize thorough investigation before expanding Ozempic’s indications to include weight loss. This includes comprehensive data on long-term effects, potential side effects, and an analysis of how it affects non-diabetic patients. “Weight loss drugs are among the most sought-after products sold in the U.S.,” said Dr. Taraneh Soleymani, director of Obesity Medicine at Penn State Health Medical Group. “However, some people cannot tolerate the gastrointestinal side effects. This phenomenon is true of essentially all weight loss interventions. Clinical trials have shown that Wegovy reduces the risk of heart problems by 20% in people who are overweight. So, just because they improve a patient’s blood sugars doesn’t mean they’ll lose significant weight.” Research has shown individuals can lose a substantial amount of weight on Ozempic, with an average 3 of 10% by 24 weeks. By mimicking the gut hormone GLP-1, Ozempic can regulate blood sugar, reduce hunger, and increase metabolism. Although these side effects are rare, taking Ozempic under the supervision of a physician who can monitor your response and ensure your safety is essential. Embracing such an integrative approach transformed my weight loss journey from reactive to proactive, fostering resilience and measurable progress.For Ozempic to become approved as a weight-loss drug, extensive research, and further testing must be done.Future research will likely focus on refining the use of GLP-1 receptor agonists, exploring potential combination therapies, and developing personalized treatment approaches that consider individual patient characteristics and risk factors․ The ongoing evolution of this field promises to bring further improvements in the management of obesity and related metabolic disorders․The study in Nature Medicine also found the medication had the potential to lower the risk of heart attack, stroke and other cardiovascular concerns.It’s not FDA approved for weight loss.Some big employers that originally covered the weight-loss drugs have pulled back.In a healthy body, the brain receives signals when it’s full.An earlier trial funded by the company showed people with Type 2 diabetes lost up to 14% of their body weight with the injection at 36 weeks, while those who took the daily pill lost 10%. Most significantly, this study found that danuglipron was able to reduce HbA1c% (ranging from 0.9% to 1.2% points lower depending on dosage) and weight (2.2 kg to 7.2 kg reduced depending on dosage) after just 28 days of administration . Currently, danuglipron is undergoing clinical trials and is being tested as an oral medication to be taken twice a day available in varying doses of 10, 20, 40, 80, or 120 mg . Existing GLP-1 receptor agonist therapies typically require subcutaneous administration which may be inconvenient for or not preferred by some patients, resulting in reduced adherence . Amanda Bynes Plans to Lose 40 Pounds While on Ozempic In light of these findings, which were published in November, the FDA’s decision to approve the drug for preventing heart problems “wasn’t surprising at all,” says Joseph Wu, a cardiologist at Stanford University. They had a 20 percent lower risk of heart attacks and strokes in the course of about three years, as well as significantly lower cholesterol and blood pressure. The participants all had a body mass index (BMI) of 27 or higher. How effective is semaglutide at preventing cardiovascular problems? Unlike the semaglutide-cagrilintide combo, amycretin is a single-molecule drug that activates both the amylin and GLP-1 receptors. Within a day of the CagriSema news, the drugmaker released the findings of two trials involving the experimental weight-loss drug amycretin, which is expected to reach the market in daily oral and weekly subcutaneous injectable form. "In REDEFINE 1, CagriSema provided weight loss in the highest range of efficacy observed with existing weight loss interventions," said lead investigator Timothy Garvey, MD, a professor at the University of Alabama at Birmingham. When comparing Ozempic to other weight loss medications, it is important to remember that it is not licensed for weight loss in the UK. As mentioned, Ozempic is licensed solely for type 2 diabetes in the UK, however, Wegovy includes the same active ingredient (semaglutide) and can be used in the UK for weight loss. If you need a medication for weight loss and your doctor thinks semaglutide is a good option then they will usually prescribe you with Wegovy. The medication is most effective when used in combination with a healthy diet and regular exercise, and it’s important to work closely with a healthcare provider to monitor progress and adjust treatment as needed. Ozempic has been shown to be effective in reducing HbA1c levels, a measure of average blood sugar control, and has a low risk of hypoglycemia compared to other diabetes medications. While Ozempic is currently only approved by the FDA for the treatment of type 2 diabetes, it is often prescribed off-label for weight loss in individuals who do not have diabetes. It may also be prescribed for individuals with a lower BMI if they have other health conditions, such as type 2 diabetes or high blood pressure, that would benefit from weight loss. One medication that has garnered significant attention in recent years is Ozempic, a type 2 diabetes treatment that has shown promising results in facilitating weight loss. Ozempic, also known as semaglutide, is a glucagon-like peptide-1 (GLP-1) receptor agonist.I tell my patients to plan for long-term use, which is why cost is important to discuss up front.Ozempic, which is the brand name of the injectable form of semaglutide, is a newer and stronger drug.This week, the White House announced a deal with Eli Lilly and Novo Nordisk to lower the cost of their GLP-1 weight loss drugs, Wegovy and Zepbound.Basically, these drugs were discovered from some of the research we did on how gastric bypass works.People using Ozempic long-term should be followed closely by a healthcare provider to catch any problems early.If you qualify, Noom Med will connect you with a clinician who can prescribe Ozempic® or another medication.My healthcare provider adjusted my dosage gradually and combined the medication with lifestyle advice.At resM, we created a GLP-1 postbiotic supplement for metabolic weight control to help. In 2024, Corona began scaling back on the medication because she felt she wasn't eating enough calories to be able to work out, she explained on TikTok. Corona described the weight-loss process as gradual and still requiring food discipline and regular exercise to work. She plans to keep taking the drug hoping to lose a few more pounds, but if that doesn't happen over time, she says she'll probably discontinue it. It’s important to remember that Ozempic is a chronic weight management medication, and it’s intended for long-term use. However, individual results may vary, and some people may see more rapid or slower weight loss. In clinical trials, significant weight loss was observed as early as 4-6 weeks after starting treatment, with continued weight loss seen over the course of weeks. These side effects are typically mild and short-lived, and can often be managed with anti-nausea medications or other supportive care. Along with eating well and exercising, Ozempic can improve blood sugar and lower the risk of stroke, heart attack, or death in adults living with type 2 diabetes.¹⁰ Type 1 diabetes treatment focuses on insulin therapy. Type 1 diabetes is an autoimmune condition that stops your body from making insulin, and a way to prevent it hasn’t been discovered yet. Type 2 diabetes is a condition involving high blood sugar (glucose) levels due to low insulin sensitivity, also known as insulin resistance. That being said, drugs containing semaglutide are demonstrating expansive potential to address several different aspects of health and can be prescribed off-label by licensed medical professionals, at their discretion. According to major trials, semaglutide can lead to meaningful weight loss when combined with healthy habits, but side effects, cost, and access matter—and weight often returns if you stop. The long-term benefits include significant weight loss, improved metabolic health, and potential reductions in obesity-related diseases such as type 2 diabetes and heart disease. For instance, patients using Ozempic in combination with lifestyle interventions lost about 15% of their body weight over 68 weeks, which is a considerable reduction compared to placebo groups. While the drug may guarantee weight loss for some users, others may not enjoy the same promised benefits. According to Kushner, users could regain weight if they do not follow healthy lifestyle changes alongside the medication. This means it mimics the action of a natural hormone in the body that helps regulate blood sugar levels. Ozempic is an injectable medication that contains semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist. With this structured approach, we aim to provide you with a comprehensive understanding of Ozempic and its implications for weight loss, ensuring you feel informed about your options. In this post, we’ll explore the science behind Ozempic, the evidence supporting its use for weight loss, and the alternatives available for those seeking to manage their weight. In this blog post, we’ll delve into the facts surrounding Ozempic, its intended uses, and its implications for weight loss. Knowing this, certain patients may avoid potential complications by avoiding semaglutide use. As with any medication, Wegovy comes with potential risks and side effects, as noted by the FDA approval. Those on Wegovy lost an average of 6.2 percent of their starting body weight versus those in placebo. Those who received Wegovy lost an average of 12.4 percent of their starting body weight versus those on placebo. Here, Soleymani discusses these medications and provides context and clarity around how they work, how they’re used and prescribed, and what the potential side effects might be. “People don’t have to hear about the new weight-loss drugs from their doctor. Like Ozempic, Wegovy contains semaglutide as its active ingredient, however, it is licensed to treat weight loss whereas Ozempic is not. Plans must opt-in, and beneficiaries will need to meet their plan’s deductibles while also having obesity with comorbidities to qualify for coverage. However, under the new pilot program, beneficiaries could see their out-of-pocket costs drop to between $50 and $149 per month, making this medication more accessible. The new data also found possible side effects that were not previously known. A Kaiser Family Foundation poll found that one in 8 American adults reported trying a GLP-1 medication. Healthcare providers will need to carefully consider the benefits and risks of Ozempic for weight loss, as well as its potential interactions with other medications. This could pave the way for a new era in obesity treatment, offering a more effective and sustainable solution for individuals struggling with weight loss. While Ozempic has demonstrated impressive weight loss results, its FDA approval remains limited to type 2 diabetes treatment. It is a once-weekly injectable medication approved by the FDA in 2017 for the treatment of type 2 diabetes. With the rising prevalence of obesity and related health issues, the quest for effective weight loss solutions has become a pressing concern. With that rise in obesity comes an increased risk for heart disease, stroke, type 2 diabetes, and some cancers. Please note that a GLP-1 medication may not be appropriate in all patients. "Weight regain after stopping treatment may affect the long-term sustainability of the observed benefits. More independent studies from a public health perspective are needed." "We need more data on the long-term effects and other outcomes related to cardiovascular health, particularly in lower-risk individuals," says Eva Madrid, co-lead researcher from the Universidad de Valparaíso, Chile. The goal of this article is to give you trustworthy information based on science and medical research. Losing weight takes time, and results can vary from person to person. It will answer the most common questions people are searching for online. After that, they said, I'm done with these meds, and I'm going to have surgery so that I don't gain this weight back. I have a patient for whom I did a lap band; she lost a bunch of weight, but then decided she wanted to lose more and went on Mounjaro and got down to the weight she really wanted to reach. And some just didn't lose that much weight. It’s also worth remembering that New Zealand and the US are the only two high-income countries that allow prescription drugs to be marketed directly to consumers. Losing weight can make it easier to exercise and lower the risk of heart disease and diabetes. Dieting and exercise alone are not helpful for many people – medical interventions can be more effective than sheer willpower. People using these drugs can forget to eat, which can make them lightheaded, dizzy and bad at focusing. Patients who experience sudden vision loss should stop taking the drugs and see a doctor immediately, Katz advised. "We take all reports about adverse events from use of our medicines very seriously. This also relates to eye conditions, which are well-known comorbidities for people living with diabetes." NAION is a very rare eye disease, and it's not an adverse drug reaction listed on the labels for semaglutide in the form of Ozempic, Rybelsus and Wegovy, Novo Nordisk said in a statement. But the authors of both papers said they can't determine if the antidiabetic drugs cause eye complications until large clinical trials are done. And this is really a better tolerated, more effective drug than we've ever had. I don't know yet how this will work out on the medical versus surgical end. So as soon as you lose some weight and see you’re not losing weight anymore, a large percentage stop taking it. Some patients will get bad or lifelong pancreatitis from having taken the medication.It is crucial to differentiate between medications like Ozempic and those specifically approved for weight management, such as Wegovy.Low blood sugar is a more serious risk linked to GLP-1 agonists.Compared to these medications, Ozempic has been shown to be highly effective in promoting weight loss, with clinical trials demonstrating an average weight loss of 10-15% of body weight over 20 weeks.Thinking about starting your weight loss journey with Ozempic?Ozempic can lower blood sugar and lead to significant weight loss.You may also be able to get a prescription for Wegovy online, using a telehealth service. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Semaglutide injection is in a class of medications called incretin mimetics. You will be given the Medication Guide when you begin treatment with semaglutide injection and each time you refill your prescription. Trulicity’s dulaglutide offers steady effects with a longer half-life in some aspects but less potent hunger signaling. Ozempic’s semaglutide structure binds more strongly to receptors, often resulting in greater appetite control. Dose escalation plays a key role in unlocking each medication’s full potential. Trulicity, with dulaglutide, provides reliable but generally milder effects in head-to-head data. The activity of GLP-1 deteriorates with poor glucose control in the body; hence, its efficacy is reduced further in patients with diabetes . Glucagon-like peptide 1 (GLP-1) agonists belong to a class of type-2 diabetes medications that mimic the function of the GLP-1 hormone secreted by the pancreas . But weight-loss advocates warn there are long-term health risks of obesity, too. This process suppresses hunger and leads to weight loss — but that can take a toll on the body. Wegovy is FDA-approved for weight loss; Ozempic and Mounjaro are not. Use of Ozempic for weight loss in Australia is considered “off label”. Social media is full of posts and endorsements by celebrities who are using it for weight loss. By being informed and taking a proactive approach, you can navigate your weight loss journey with confidence and clarity. These groups would need to ensure they are getting adequate calcium, vitamin D and magnesium through their diet as these are critical for bone health. Patients often report reduced desire for sweets and fatty foods, creating an opportunity to adopt healthier habits. GLP-1 signals travel from the gut to the brain via the bloodstream and the vagus nerve. Unlike other weight-loss medications, Ozempic also improves insulin sensitivity, reduces inflammation, and slows down digestion, leading to more sustainable weight loss.” These combined effects help control blood sugar and lead to weight loss, the doctor simplified. Dr Mahesh D M, Consultant Endocrinologist, Aster CMI Hospital, Bengaluru, said, "Ozempic functions as a glucagon-like peptide-1 (GLP-1) receptor agonist, which not only helps lower blood sugar levels but also plays a significant role in weight management, making it a dual-purpose solution for those struggling with diabetes and obesity." To tackle the same, Onlymyhealth spoke to two endocrinologists to understand the role of Ozempic, whether or not it can be taken to lose weight, and the potential risks and side effects that can follow after the drug's usage. So far, Medicare, the health insurance program for 66 million Americans 65 and older, doesn’t cover the drugs for obesity. How to manage GLP-1 side effects Learn about normal TSH levels and what high or low levels might mean for your health. This article explains how TSH levels regulate your body's metabolism and energy production, the symptoms that may indicate a need for testing, and what to expect from the test procedure. Discover the importance of a TSH test for assessing thyroid health. Since food moves more slowly through the body, some people may have trouble going to the bathroom. Ozempic is a prescription medicine that can help with weight loss. Working with a doctor is key to finding the right dose and using Ozempic safely for weight loss. Each step is done carefully to help the body adjust and avoid side effects. In some cases, people may stay on a lower dose longer if they are having side effects or are happy with the results. With all these therapeutic benefits, it’s no wonder that the US FDA gave its stamp of approval to semaglutide. As a result, you have fewer cravings and don’t feel like eating as much, leading to weight loss. Specifically, we’ll look into what exactly the drug is approved for and its proven effectiveness in clinical trials. In addition to the cosmetic effects of weight loss drugs, these medications can also cause health side effects. US health policy and prescription drug coverage of FDA-approved medications for the treatment of obesity. Many patients have reported trouble getting prescribed medications covered by insurance when they're labeled for obesity – one example of how health care for bigger bodies is complicated by cultural biases, even when weight loss is the goal. Injections of semaglutide (the ingredient in both drugs) are currently on the US Food and Drug Administration's list of shortages. Because of society's jagged relationship with diet pills, some people are asking questions about the medications -- whether they're safe enough, if they're even ethical to take and who should be using them in the first place. Pop culture continues to shine a light on Ozempic, a diabetes drug, and its weight-loss counterpart, Wegovy. Most side effects of GLP-1 drugs are not serious. The drugs are expensive, ranging from $900 to $1,400 per month—with variable insurance coverage. The ethical concerns surrounding drugs like Ozempic, Rybelsus, and Wegovy focus in part on issues of equity and access. This led to a surge in its off-label use as a weight-loss aid, propelling the drug into the spotlight far beyond its original intent. Columbia Psychiatry News spoke with Dr. Klitzman about the ethical and health concerns surrounding the use of AOMs and the long-term risks and benefits that must be considered in tackling the obesity epidemic and broader public health challenges. Since its initial approval, Ozempic has undergone additional clinical trials to evaluate its potential use for weight loss. It does this by lowering blood sugar levels, reducing blood pressure, and improving cardiovascular health. It is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means it works by mimicking the action of a natural hormone in the body that helps to regulate blood sugar levels and appetite. The story of Ozempic’s approval for weight loss is one of dedication, perseverance, and innovation. While many users tolerate these effects with time, they can be bothersome for some individuals. Individuals taking Ozempic may experience a range of side effects, with gastrointestinal issues being the most commonly reported. Nonetheless, healthcare providers sometimes prescribe it off-label for this purpose. Unsurprisingly, many people using Ozempic have reported a decrease in cravings and an easier time adhering to dietary restrictions, which can be beneficial for those looking to shed pounds. Ozempic works by stimulating insulin secretion from the pancreas in response to food intake while simultaneously inhibiting the release of glucagon, a hormone that raises blood sugar levels. Consulting with your healthcare provider about potential risks and benefits is essential. Common side effects include nausea, vomiting, diarrhea, abdominal pain, and headaches. Effective weight management requires commitment to dietary changes and regular physical activity. Ultimately, the decision to use Ozempic should be made in consultation with your healthcare provider. When administered, Ozempic helps the body produce more insulin in response to meals, lowers the amount of glucose produced by the liver, and slows down gastric emptying. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. In a note in August, Goldman Sachs analysts forecast that pills will capture a 24% share — or around $22 billion — of the 2030 global weight loss drug market, which they expect to be worth $95 billion in total. While people in the Zepbound group appeared to regain more weight, the bigger focus is likely on those who transitioned from the drug's top competitor, Wegovy. That means people in the Wegovy group maintained about 95% of their weight loss after switching, while those in the Zepbound group maintained roughly 80%. While Eli Lilly's pill appears to cause less weight loss overall than existing injections, Thursday's results highlight its potential role as a needle-free maintenance treatment in the blockbuster GLP-1 market. Doctors prescribe metformin to lower blood sugar levels in people with prediabetes. Also, exercise regularly and test for sugar in your blood or urine as directed. This is the most important part of controlling your diabetes, and is necessary if the medicine is to work properly. This will help lower the chance of having very low blood sugar. When you start using this medicine, it is very important that you check your blood sugar often, especially before and after meals and at bedtime. The presence of other medical problems may affect the use of this medicine. When considering weight loss options, understanding the differences between these medications can help you and your healthcare provider decide which solution aligns best with your health goals. There are several other FDA-approved medications for weight loss, each functioning through different mechanisms. While Ozempic has shown effectiveness in weight loss, it’s important to distinguish it from other medications designed specifically for this purpose. Ozempic, generically known as semaglutide, was approved by the FDA in 2017 for adults with type 2 diabetes but has since been recognized for its weight loss benefits. At TrimRx, we believe in partnering with our patients to create individualized weight loss strategies that encompass these essential components. Choosing medications that have received FDA approval means patients can trust that they have undergone rigorous testing for safety and efficacy. The FDA approved Wegovy for chronic weight management in adults with obesity or overweight who also have at least one weight-related condition. Research has shown that individuals using Wegovy can achieve significant weight loss, with studies indicating an average reduction of 15% to 20% of initial body weight over a 68-week period. Wegovy and Zepbound are shown to have a higher weight loss percentage and are also FDA-approved for long-term use, unlike Ozempic. This particularly affects people with diabetes seeking access to this treatment, causing some to pay as much as $1600 out of pocket per month if their insurance doesn’t cover it. The 40-fold increase of Americans suddenly taking these drugs came after both industry and consumers realized their potential use for weight management. "Semaglutide is a long-term therapy, because you're going to lose the benefits once you stop the medication," explains Dr. Mahali. Patients can indeed get semaglutide prescribed off label, especially if they're able to pay for it out of pocket. It's a price I'm willing to pay, especially knowing I will likely regain weight if I stop cold turkey. These effects can lead to eating less and losing weight over time. For people without diabetes, Ozempic still works the same way. Talk to a healthcare provider before making any changes, and remember that weight management is a lifelong journey, not just a short-term fix. Having a plan to stay healthy—through good eating habits, exercise, and medical guidance—is key. Many people gain back some or all of the weight they lost. What is now approved for adults will soon be being used by other groups, with or without regulatory approval—by children, the worried well, those who need to maintain low weight for their jobs (in particular, members of the military). Then, on November 8, 2023 the FDA granted Lilly, which manufactures Mounjaro, approval to sell/market its new drug Zepbound for chronic weight management. Other injectables that also help lower weight such as Ozempic, Mounjaro and Saxenda rapidly entered the market, along with various non–FDA approved products like Aqualyx, Lipodissolve and concoctions brewed up by specialty pharmacies and sketchy wellness clinics. The FDA has also approved Ozempic to help reduce the risk of worsening kidney disease, kidney failure, and death due to cardiovascular disease in adults with type 2 diabetes and chronic kidney disease. This can help individuals eat less, leading to an average weight loss of 15% when combined with diet and exercise. If you continue, you will be evaluated for the membership-included medications to see if your Clinician thinks you're a good fit, or choose to pay without insurance for GLP-1 medications. “It’s like telling somebody to nail a nail into a board and then giving one person a hammer and another person, you know, like a chopstick,” Varney said, adding, “we’re leveling the playing field with these medications.” Doctors and researchers say the injectable drugs are a effective tools when it comes to treating obesity. Strong demand and public health concerns continue to stimulate interest in GLP-1 drugs. Despite the popularity of Ozempic and other GLP-1 drugs, concerns remain about their side effects and high cost, which could limit their uptake. The Peterson Center on Healthcare and KFF are partnering to monitor how well the U.S. healthcare system is performing in terms of quality and cost. The U.S. has by far the highest rate of obesity among peer nations—a third of adults (33.6%) have obesity in the U.S. compared to an average of 17.1% across peer nations. Private insurers and employers in the U.S. may be able to negotiate lower prices with drug manufacturers or get larger rebates. A one-month supply of the oral tablet form of semaglutide, Rybelsus, is priced similarly to Ozempic at $936 in the U.S., which is over 4 times as much as the price in the Netherlands ($203). Semaglutide drug prices are typically much lower in other large, wealthy countries than found in the U.S. Everything we know about these medicines suggests you can't stop them without gaining back the weight and losing any gained control over diabetes, Khan says. Half or more of patients experience nausea, which usually fades in time as patients stick with treatment. "It suggests to me that we're going to see this used for a lot more than just diabetes and obesity," Khan says. Insulin then helps blood sugar move into the body's cells to be used for energy. Patients and their doctors are increasingly turning to in-demand drugs like Ozempic and Wegovy, but are they safe and effective? What Does Semaglutide Do to the Body? When patients stop taking Ozempic, evidence suggests that two-thirds of the weight lost is regained within one year. While Ozempic has potential advantages over other standard-of-care diabetes interventions, it does not have an advantage over other standard-of-care interventions for long-term weight management. According to CNN, 1.7% of all Americans used GLP-1 drugs, which include Ozempic, Mounjaro, and Wegovy in 2023. The vast majority of obese patients never got effective treatment because there wasn't effective treatment, or the treatment had more significant side effects. It's opened up people's eyes to obesity as a disease now that there's effective medication for it. But it’s possible that these medications aren’t covered, or that your cost is still high. In addition to weight loss, some of them also have proven cardiovascular benefits or are approved for obstructive sleep apnea or liver disease, among other potential uses. Mounjaro is the brand name for a medication whose active ingredient is tirzepatide, approved for the treatment of type 2 diabetes. This is also true with some insurance plans like Medicare that do not cover weight loss medications. Must people remain on weight loss medication for life? As with all medications, potential side effects exist with weight-loss medications. This is an impressive amount of weight loss ― something we have not seen with previous weight loss drugs. For example, they may recommend a medication like Ozempic if you have prediabetes to help lower your risk of developing Type 2 diabetes. Does this mean that anyone can use Ozempic for weight loss? If you have Type 2 diabetes, one of the reasons you may be prescribed Ozempic is because it can help you lose weight. Ozempic is available in the UK for type 2 diabetes patients with a prescription.“Prevention starts with gradual weight loss and a proper skincare routine with hydrating ingredients like hyaluronic acid and peptides,” he said.The cost of these medications can also be a concern, mainly since some newer drugs may not be covered by insurance and could result in high out-of-pocket costs.Engaging with peers and healthcare teams through forums and commentaries not only dispels myths but also cultivates resilience.This research suggests that Ozempic can help with long-term weight management.A study in the journal Addiction found that people with alcohol addiction who used Ozempic or similar medications were 50 percent less likely to binge drink compared to those who didn't.I would like, first, for people who struggle with their weight to know it's not their fault.The analyses evaluated three GLP-1 receptor agonists used for weight management and found that each one produced clinically important weight loss when compared with placebo.Both medications share remarkably similar side effect profiles, with gastrointestinal symptoms dominating patient experiences during initial treatment phases. Knowing which medications your insurance covers can help guide your conversation with your healthcare provider. Many states may not cover weight-loss drugs for Medicaid recipients, or they may have specific requirements before coverage begins. Coverage for weight-loss drugs under Medicaid is less consistent and often determined by individual state policies. A government-run health insurance program, Medicaid usually covers Ozempic for type 2 diabetes treatment. However, we deemed the risk of attrition bias questionable since in all 4 studies, data for those who were lost to follow-up were included, which could affect the mean weight difference. The course of treatment was 68 weeks for Wilding, Rubino and Wadden et al., but only 52 weeks for O’Neil et al.’s study. O’Neil et al., used a smaller dose of semaglutide that was given once daily at 0.05 mg to 0.4 mg. However, unlike the other 2 studies where participants were randomized to receive semaglutide or placebo at the start of study, Rubino’s study randomized participants after the target dose was reached to continue with semaglutide or switch to matching placebo. Ozempic is the latest rage among celebrities thanks to people having drastic weight transformations after taking the diabetes medication. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. This medicine is also used to lower the risk of heart attack, stroke, or death in patients with type 2 diabetes, obesity, and heart or blood vessel disease.