This glucose-dependent action reduces the risk of dangerously low blood sugar (hypoglycemia), making them a safer option compared to some other diabetes treatments Semaglutide is approved to treat Type 2 diabetes (as Ozempic and Rybelsus) and for weight loss (as Wegovy). So your prescriber may need to change the dose of these medications when starting semaglutide. Ozempic copies the action of the body’s natural GLP-1. When this process doesn’t work well, sugar builds up in the blood. Insulin is a hormone that helps move sugar (glucose) from the blood into the cells. Integrating these insights into clinical practice allows for optimized treatment plans that maximize efficacy while minimizing side effects, embodying the principles of precision medicine in obesity care. While these drugs were in short supply, compounding pharmacies filled the void by selling compounded GLP-1 medications. As GLP-1 drugs became more popular for weight loss, manufacturers had difficulty meeting demands. She said people who developed NAION after taking Ozempic or Wegovy for either Type 2 diabetes or weight loss may qualify for one of these lawsuits. In June 2025, the EMA found that adults with Type 2 diabetes taking semaglutide have roughly double the risk of developing NAION compared to those not using the medication. A. Pawlowski is a TODAY health reporter focusing on health news and features. “(But) with semaglutide being out for this many years, so far nothing has emerged that’s been really new in terms of safety signals.” But I don’t think the data is there for the effectiveness of this class of drug on a long-term basis. Starting semaglutide is a commitment to stay on it long term, McGowan says. But even major weight loss from diet and exercise alone would cause these changes. Fast and drastic weight loss can cause skin to hang and sag in places that it didn’t before. At first, kidney injury and poor kidney function were listed among the possible side effects of the drug. In tests of Ozempic and similar drugs in mice, some mice developed both cancerous and noncancerous thyroid tumors. If you feel dizzy or have other signs of low blood sugar on this medicine, you should call your health care provider. One primary difference between Mounjaro and Ozempic is that Ozempic is FDA-approved to reduce the risk of heart attack and stroke in people with type 2 diabetes, while Mounjaro is not. Wegovy and Zepbound, however, are FDA-approved for weight loss, and they aren't intended to be prescribed to those with diabetes. But some insurance plans only cover Ozempic when it’s prescribed as a treatment for type 2 diabetes, not when it’s prescribed off-label as a weight loss aid. Insurance coverage for Ozempic (and all drugs, for weight loss or otherwise) varies by provider and plan. What are the side effects? This is an important consideration because diabetes increases heart disease risk. GLP-1 receptor agonists like semaglutide (Ozempic), liraglutide (Victoza), and tirzepatide (Mounjaro) help by increasing insulin secretion in response to meals, thereby lowering blood sugar levels. Most GLP-1 drugs are administered by injection into the abdomen, thigh, or upper arm. This hormone is released by the gut in response to eating and has several effects that help regulate blood sugar levels, hunger, and slow digestion. GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications that work by mimicking the natural GLP-1 hormone. Most people will move to a higher dose only if they are tolerating the current dose well and need stronger effects. Some people may have stronger side effects at this dose, while others may not need it to reach their goals. Clinical trials have shown that people at this dose often lose more weight than at lower doses. If more weight loss is needed and the person is handling the medication well, the next step is 1 mg once a week. Some people stay at this dose if they respond well to it and are not having many side effects. For example, they may recommend a medication like Ozempic if you have prediabetes to help lower your risk of developing Type 2 diabetes. But if you don’t have diabetes, it’s also possible that your prescriber may prescribe Ozempic for weight loss. GLP-1 receptor agonists like Ozempic help to lower your blood sugar levels, but people using them also tend to lose weight. That’s because Ozempic works longer in your body compared to other medications that need to be injected once or twice a day. Ozempic (semaglutide) is a GLP-1 receptor agonist approved to treat Type 2 diabetes. At TrimRx, we believe in providing you with accurate, science-backed information to guide your health decisions. By the end of this article, you’ll have a comprehensive understanding of Ozempic’s role in weight management and what the future may hold for its FDA approval in this area. With approximately 42% of American adults classified as obese, the search for effective weight management solutions has intensified. Our programs combine cutting-edge telehealth innovations with medically supervised care to create tailored weight loss solutions. At TrimRx, we harness the power of telehealth to deliver comprehensive, individualized weight loss solutions, ensuring that every patient receives the support they need throughout their journey. The emergence of Ozempic as a popular weight loss option has had significant implications for both individuals and the healthcare landscape. The trial’s success led to the FDA approving a higher dose of semaglutide, branded as Wegovy, specifically for weight management later that year. In 2021, Novo Nordisk conducted a clinical trial specifically designed to evaluate semaglutide’s impact on weight loss. LOA and PTSR Model - Empagliflozin in Chronic Kidney Disease (Chron... While their benefits are clear, they also come with potential risks and side effects. People with diabetes face higher risk of hearing loss Semaglutide and cardiovascular outcomes in obesity without diabetes. The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity. If you’re having difficulty tolerating the medication, they can give you tips for how to manage certain side effects. Semaglutide was found to significantly reduce blood sugar levels as well as body weight. Over 650 million people are suffering from obesity worldwide, and around 480 million, meanwhile, have type 2 diabetes. As consumers grapple with the shortage, healthcare providers have been turning to alternatives to treat type 2 diabetes and obesity. At the federal level, the Trump administration decided not to proceed with a Biden administration proposal to allow Medicare and require Medicaid to cover obesity drugs but recently launched their own obesity drug coverage initiatives to reduce costs and increase access (see Box 1). But the shortages and challenges with insurance coverage have made it difficult for many patients to get the drugs. Zepbound is approved to treat obesity and Mounjaro is approved for diabetes. But patients may still see some supply disruptions as the medications move from the manufacturer to distributors and then to pharmacies. A woman holds up a dosage of Wegovy, a drug used for weight loss, at her home in Front Royal, Va., on March 1, 2024. As for the most common side effects, both drugs may lead to nausea and diarrhea. He adds that other important factors to consider are the cost of the medications themselves as well as their potential side effects. Metformin is FDA-approved as a treatment option for type 2 diabetes and is sometimes used off-label for conditions like polycystic ovary syndrome (PCOS), reveals Dr. Glickman. “They share a role in managing type 2 diabetes, but they differ significantly in their mechanisms and effects,” reveals obesity medicine physician Michael L. Glickman, MD. She emphasizes that patient responses to these medications vary widely and the need for higher doses doesn’t necessarily correlate with how much weight someone needs to lose. But when the FDA finally gave pharmaceutical companies approval to use these same drugs for weight loss, demand for them skyrocketed. “I’m playing doctor,” Bookless said, describing her foray into the world of do-it-yourself GLP-1 medication, injections developed to control diabetes and now also used for weight loss. These changes align with what many regular users of these medications report. This rapid weight loss causes a reduction in subcutaneous fat — particularly noticeable in the face. Ozempic, along with similar drugs like Wegovy and Mounjaro, increases satiety and slows digestion, helping users eat fewer calories. Manufactured by Novo Nordisk, this glucagon-like peptide-1 (GLP-1) receptor agonist helps regulate blood sugar levels, promoting insulin secretion and suppressing glucagon release. They can help guide you through the available options and potential risks and benefits. While off-label use may seem like a viable solution, it comes with significant risks and uncertainties. While some may opt for off-label use, this approach comes with inherent risks and uncertainties. Additionally, insurance coverage for off-label use is often limited, leaving patients with significant out-of-pocket expenses. Wegovy is administered in higher doses than Ozempic and is intended for those with a body mass index (BMI) of 30 or greater, or a BMI of 27 or greater with at least one weight-related health condition.This risk hasn’t been confirmed in people.It is specifically indicated for the management of type 2 diabetes and is often prescribed off-label for weight loss.It is crucial for individuals considering Ozempic for weight loss to discuss their health history and potential risks with a healthcare provider to ensure the medication is appropriate for them.Its FDA approval in 2017 marked a milestone in treatment options for individuals with chronic conditions.When blood sugar goes up, GLP-1 encourages your body to make more insulin to lower blood sugar. We encourage you to take our free assessment quiz to evaluate your eligibility for prescription weight loss medications. Ozempic is not approved for weight loss and should only be used for its intended purpose of managing type 2 diabetes. These medications are typically prescribed as part of a comprehensive weight loss plan that includes dietary changes, physical activity, and behavioral counseling. If you are prescribed Ozempic or any weight loss medication, it is vital to have regular check-ins with your healthcare provider. The experience of weight loss while on Ozempic has led to increased interest and requests for the medication, even among individuals without diabetes. Some patients may also experience allergic reactions or complications related to pre-existing conditions. On the more serious end of the spectrum, there are risks of pancreatitis, kidney problems, and an increased heart rate. Common side effects include gastrointestinal issues such as nausea, vomiting, diarrhea, and constipation. A healthcare professional can provide personalized guidance, taking into consideration the individual’s overall health, dietary habits, and any existing medical conditions. By stimulating insulin secretion and suppressing glucagon release, the medication encourages a feeling of fullness, which can lead to reduced caloric intake. The nice thing about medication is you can come off it. Maybe even a better situation because it's a natural substance that's in your body that we're just augmenting. I have heard people talk about the quieting down or the food yearnings. Some people say that surgery turns that around for them. Now, there is a percentage of patients who are addicted. GLP-1, or glucagon-like peptide-1, is a natural hormone that helps your body keep blood sugar in balance. To understand type 2 diabetes, you need to know what insulin is and why your body needs it. Type 2 diabetes occurs when the body does not make enough insulin or doesn’t respond to insulin properly. Non-insulin Ozempic® works with your body’s own ability to lower blood sugar and A1C. A study showed that in adults with type 2 diabetes and known heart disease, Ozempic® lowers the risk of major cardiovascular events such as stroke, heart attack, or death. Bookless then talked to her own doctor, who told her it wasn’t medically necessary and insurance wouldn’t pay for it because her body mass index wasn’t high enough to qualify her for coverage (without insurance, the cost can be $1,300 a month). Join the millions who have discovered that Noom is the smartest way to not only lose more weight—but also keep it off—to live better, longer. At Noom, we’re committed to providing health information that’s grounded in reliable science and expert review. Your specialist might team up with other healthcare providers or programs like Noom to give you comprehensive support on your journey to better health. Most of the studies included demonstrated a positive effect of semaglutide for obesity treatment. Following treatment withdrawal, semaglutide and placebo participants regained 11.6 and 1.9 percentage points of lost weight, respectively, by week 120, resulting in net losses of 5.6% and 0.1% respectively . From week 0 to week 68, mean weight loss was 17.3% with semaglutide and 2.0% with placebo . Some 40% of participants who continued semaglutide lost an additional 10% of body weight during the randomized period with a mean change in weight of −7.9% vs +6.9% in semaglutide and placebo groups respectively from week 20 to week 68 . "These medicines are the opening to a whole new era of treating metabolic disease," says Dr. Louis Aronne, an obesity specialist at Weill Cornell Medicine, one of the co-authors of the SURMOUNT-1 study. Eli Lilly is seeking FDA approval for tirzepatide for chronic weight management. “The hope with this latest approval for heart health is that more insurance companies will provide greater coverage, which would be a good first step.” About a third of the SELECT trial participants reported serious side effects, and about 17% in the group that took Wegovy and 8% of those who received a placebo left the study for that reason. “Now, we may be able to treat obesity directly, which could turn the tide on the current trends in heart disease.” These drugs mimic the effects of GLP-1, a naturally occurring hormone that regulates blood sugar levels and promotes a feeling of fullness. While Ozempic is currently only approved to treat type 2 diabetes, many doctors are already prescribing it off-label for weight loss in individuals without diabetes. This is significantly more than what is typically seen with diet and exercise alone, and is comparable to the weight loss seen with other prescription weight loss medications. At TrimRx, we are dedicated to providing personalized, medically supervised weight loss solutions that empower individuals to achieve their health goals safely and effectively. Our patients benefit from unlimited support throughout their weight loss journey. Our team of healthcare professionals provides ongoing medical supervision throughout your weight loss journey. Since Ozempic is approved for type 2 diabetes and not PCOS, many insurers may deny coverage when the medication is prescribed solely for PCOS management. Remember, too, that as effective as these medications may be, they can’t solve emotional issues related to eating and weight. As prescription drugs go, semaglutide and tirzepatide are relatively new, so there’s a lot we still don’t know about them. Similarly, anyone with a history of pancreatitis should discuss the safety of these medications with a healthcare provider. If you are ready to take the first step toward achieving your weight loss goals, we invite you to take our free assessment quiz today. Our journey began with a vision to help individuals embrace healthier lifestyles by merging cutting-edge telehealth innovations with effective weight management solutions. At TrimRx, we believe that sustainable weight loss should be achieved through a combination of advanced medical science, personalized care, and empathetic support. TrimRx offers a comprehensive weight loss program that includes consultations, lab work, and unlimited support to guide you through your journey. However, lawsuits allege that Novo Nordisk failed to adequately warn patients of serious risks. More than 1,800 lawsuits have already been filed in U.S. courts, with patients alleging the drug caused stomach paralysis, vision loss, gallbladder disease, and other life-altering complications. Your doctor may order certain lab tests to check your body’s response to semaglutide. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. Semaglutide injection also slows the emptying of the stomach and may decrease appetite and cause weight loss. View All Health The goal is to find the right dose that works for the individual while keeping side effects as low as possible. Ozempic (semaglutide) is a prescription injection that must be started at a low dose and slowly increased over time. In short, Ozempic helps people lose weight gradually. At TrimRx, we are dedicated to providing personalized weight loss solutions that are safe and effective. Discover the causes, symptoms, and treatments for forehead bumps, and learn when to seek medical care for your skin health. Learn about treatment options, self-care measures, and more to take control of your health and get back to your daily activities faster. With over 8 million visits managed through Solv, we've made healthcare more accessible and affordable, saving people over $200 million in medical bills. Many people notice smaller portions and less snacking within 1–2 weeks as doses rise, with full effect after several titration steps. Moreover, using Ozempic for weight loss without medical supervision can lead to inappropriate dosage or duration of use.A premium is the cost of having a health insurance plan and is usually paid monthly.Clinical trials have shown that taking either semaglutide or tirzepatide can make you lose weight.So, just because they improve a patient’s blood sugars doesn’t mean they’ll lose significant weight.”GLP-1 agonists for type 2 diabetes are generally taken by a shot, also called an injection.Talk to your doctor about the risks of using semaglutide injection. Obtaining Wegovy Mild stomach pain is another common GI semaglutide side effect. If needed, your healthcare team may recommend an OTC anti-gas remedy, such as simethicone (Gas-X) for bloating relief. Similar to other gastrointestinal (GI) side effects, dietary and lifestyle changes may help. You may also experience gas and bloating from semaglutide. Weight loss that resulted from the drug was probably "a major contributor" since it led to less stress on the knee joints, the authors wrote. The company didn't address the arthritis risk finding specifically, but said it welcomes independent research investigating the safety, efficacy and clinical utility of its products. No safety signal been found so far when it comes to lean mass loss with semaglutide, it adds. "I was like, 'I bet the second I go off, I'm going to get starving again.' I did, and my binging got so much worse. So then I kind of blamed Ozempic. I gained double the weight back after." She took it despite having "a lot of mixed feelings." And when she decided to stop taking the drug, her binge-eating disorder almost immediately returned. Plus, according to the study published in the Journal of Pharmacology and Therapeutics, researchers also found that a side effect of transitioning off Ozempic can result in weight gain. This includes things like acute pancreatitis and, if injecting Ozempic, an increased risk of developing tumors in the thyroid gland, Dr. Boyer says. Studies show that it works well over time, but people often regain weight if they stop.We assessed the use of oral and subcutaneous semaglutide in our article.Ozempic is the brand name for semaglutide, a medication that belongs to a class of drugs called GLP-1 receptor agonists.As obesity rates climb, the demand for effective weight loss solutions has surged, placing medications like Ozempic at the forefront of public and medical discourse.The loss of too much body fluid may make it dangerous for you to take this medication.Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. The vast majority of obese patients never got effective treatment because there wasn't effective treatment, or the treatment had more significant side effects. It's opened up people's eyes to obesity as a disease now that there's effective medication for it. These drugs are also known to enter into the bloodstream and eventually into the brain. These figures highlight how Mounjaro’s dual hormone approach may translate to enhanced, faster, and more sustained weight management results. By widening the hormonal response spectrum, Mounjaro offers a more comprehensive approach to managing blood sugar and appetite regulation. Tirzepatide’s activation of both GLP-1 and GIP receptors means it mimics the effects of two gut hormones, potentially enhancing control over appetite and glucose metabolism beyond GLP-1 alone. We’ll discuss their mechanisms, effectiveness, side effects, safety profiles, and more. For commercially insured patients. Know the symptoms of low blood sugar and know how to treat it. This test shows what your average blood sugar (glucose) level was over the past 2 to 3 months. If you have questions about a missed dose, contact your care team for advice. Weight loss has long been a significant challenge for many individuals striving to achieve a healthier lifestyle. The US Food and Drug Administration (FDA) has recently warned consumers of the dangers of using compounded formulations that contain particular salt formulations of semaglutide. Compounding is the practice of combining, mixing, or altering ingredients of a drug to create a formulation tailored to the needs of an individual patient. The active ingredient in Ozempic, semaglutide, is a delicate peptide molecule made up of two small chains of amino acids. This is when a doctor prescribes a medicine for a purpose outside of what is approved. The best way to save on GLP-1 and GIP/GLP-1 agonists is by using your health insurance. There are many ways to save on glucagon-like peptide-1 (GLP-1) receptor agonists like Ozempic (semaglutide) and Trulicity (dulaglutide). Lower-cost single-dose vials are available through LillyDirect for $299 (2.5 mg), $399 (5 mg), and $449 (7.5 mg, 10 mg, 12.5 mg, and 15 mg) per month. For future fills and for other Wegovy doses, pay $349 per month for the injection and $299 per month for the pill. After that, most ongoing fills are priced at $349 per month, depending on the dose. It’s a fact that diet and exercise only work for a minority of obesity patients who want to lose weight, because they’re incredibly difficult to stick with. While the drugs are relatively safe, there is potential for uncomfortable side effects—mainly nausea. When people who struggle with obesity—despite the best available coaching and advice—try these medicines, they describe feeling what it must be like to not struggle with appetite and weight. A hormone that’s produced in the body’s intestines, GLP-1 responds to food intake. Belviq, which was approved by the FDA in 2012, was taken off the market a short eight year’s later over cancer concerns. They include heart disease, diabetes, depression, sleep apnea, anxiety, and a life-expectancy that is greatly reduced. The complications of obesity are many and they are dangerous. In the U.S. alone, it’s estimated the 70 percent of adults are overweight while another 40 percent are considered obese. While Ozempic was initially approved for diabetes management, its potential for weight loss was recognized shortly after its release. The pivotal trials focused on its efficacy in controlling blood sugar levels and weight loss in individuals with type 2 diabetes. We will also explore TrimRx’s personalized weight loss solutions, which include medications like Ozempic and other effective programs tailored to individual needs. Studies showed that patients on Ozempic lost an average of 15-20% of their body weight, making it a highly sought-after option for weight management. The active ingredient, semaglutide, also promotes weight loss by reducing appetite and slowing digestion, making you feel fuller for longer. Ozempic is a GLP-1 receptor agonist that helps control blood sugar in people with type 2 diabetes. As the buzz around Ozempic continues to grow, many people are asking, Will insurance cover Ozempic for weight loss soon? Always remove the needle right after you inject your dose. Do not use semaglutide if it is colored, cloudy, thickened, or contains solid particles, or if the expiration date on the pen has passed. Always look at the semaglutide solution before you inject it. Ask your pharmacist or doctor if you have any questions about how to inject this medication. Do not stop using semaglutide injection without talking to your doctor. What will Ozempic do for weight loss? However, some plans do cover weight loss treatments, several doctors said. Total weight loss can range from 5 percent to 30 percent of total body weight. And after a few months on the max dose, they lose about 15 percent of their body weight, according to Dr. Ergin. Remember, Ozempic is a medication that should only be used under the guidance of a healthcare professional and as part of a comprehensive treatment plan. As with any medication, it’s essential to weigh the benefits and risks of Ozempic and discuss its use with a healthcare professional. While its indication for weight loss in non-diabetic individuals is still unclear, ongoing and future research may provide further insights into its potential as a weight loss treatment. Ozempic may increase the risk of hypoglycemia when used with other glucose-lowering medications, especially insulin and sulfonylureas. Ozempic is only prescribed to people who have a Body Mass Index, known as BMI, of 35kg/m2 or more and have additional psychological or other medical conditions that are related to obesity. Always take this medication exactly as your healthcare team has told you. This drug can also reduce the risk of heart disease and stroke. Ozempic is a type of medication you might need to take if you have type 2 diabetes. For most people, its side effects are expected to be mild and manageable, while the more serious ones, such as eye disorders, are rare. There’s a possibility that as more people demand access to medications like Ozempic for weight management, some insurers may adjust their policies. Although it’s FDA-approved for diabetes, many doctors have begun prescribing Ozempic off-label for weight loss due to its effectiveness. Originally developed for type 2 diabetes, Ozempic’s surprising effectiveness in helping people shed pounds has sparked interest as a potential weight loss solution. No matter how effective doctors and patients say microdosing weight-loss drugs are, this form of medical experimentation may be short-lived. Because early research shows many patients regain weight once they cease use of GLP-1, Bhatia says many doctors expect patients to use these medications for the rest of their lives. For example, some people taking birth control pills have become pregnant while using Ozempic. Ozempic doesn’t have many known drug interactions. But it’s still important to understand what might interact with it, affect how well it works, or worsen side effects. For most people, they get better over time. These side effects are also common after your dosage is increased. New clinical trials show that orforglipron and another oral drug help people with obesity lose weight. "I get this question a lot from patients and providers. Not many people may know obesity was recognized as a disease by the American Medical Association in 2013. It is a chronic and relapsing disease much like hypothyroidism or cancer. Once you treat the disease, the patient should stay on the treatment that works long term," Soleymani said. "When patients are properly monitored, guided and supported from a lifestyle modification standpoint (nutrition, physical activity and behavior), they tolerate the medication better. This is what we aim for with Penn State Health’s lifestyle program for obesity, Digital Weight Management. This six-month, structured lifestyle program allows us to partner with our patient in their weight-loss journey to ensure it’s safe and effective." "As with all medications, potential side effects exist with weight-loss medications," said Soleymani. "Therefore, when weight-loss medications are added to lifestyle modification, we are able to achieve and sustain a greater amount of weight loss because we are treating the disease much more effectively. Dr. Gudzune has patients taking semaglutide and tirzepatide who have reported feeling full on smaller portions, and many describe a reduction in “food noise” (ever-present thoughts about eating and food). Embarking on a weight loss journey can be challenging, but with the right support and resources, it is entirely achievable. How can I start my weight loss journey with TrimRx? Ozempic is a prescription medication and should only be obtained through a healthcare provider who can assess your individual health needs. It is important to consider lifestyle changes alongside any medication for effective weight management. The 12-milligram group lost an average of 7 percent of their body weight, and the 6-milligram group 5.1 percent. Its peptides break down too quickly in stomach acid, ruling out oral doses of the medication. Ozempic has been shown to result in an overall reduction in body weight, which may include belly fat. Clinical trials of Ozempic have also demonstrated more severe and rare side effects, which may make this medication inappropriate for specific individuals. Mounjaro vs. Zepbound side effects Every year, millions of individuals embark on weight loss journeys, exploring various diets, workouts, and even medications to achieve their goals. We believe that understanding the nuances of weight loss medications is crucial in making informed decisions. This includes those with a body mass index of 30 or higher, or a BMI of 27 or higher in individuals with health problems related to obesity, such as high blood pressure or high cholesterol. Stopping semaglutide isn’t always necessary with mild reactions. Call 911 or get immediate medical attention if you have swelling of the face, tongue, or throat, or shortness of breath after your dose. Severe allergic reactions to semaglutide, such as anaphylaxis, are rare, but still possible. Tell your healthcare team right away if you’re not urinating very much or at all, or notice swelling in your arms or legs. Ozempic’s journey from a diabetes medication to a prominent weight loss option exemplifies the evolving landscape of obesity management. In 2005, the first GLP-1 receptor agonist, Byetta, was approved for diabetes treatment, paving the way for further innovations in this class of medications. The Biden administration proposed in November to change Medicare’s coverage policy for obesity drugs, but currently, Medicare beneficiaries can get coverage for weight-loss medicines only when they’re used for another indication, like reducing heart risks. Additionally, individuals may be eligible for patient assistance programs or other forms of financial assistance to help offset the cost of the medication. However, coverage for chronic weight management may be more limited, and some plans may require prior authorization or have specific criteria for coverage. In general, Ozempic is covered by many commercial insurance plans, as well as Medicare Part D, when prescribed for type 2 diabetes. It’s important for individuals to talk to their healthcare provider to determine if Ozempic is a suitable option for their individual needs. This distinction is crucial because it underlines the importance of having a healthcare provider involved in any weight loss journey.In a pivotal clinical trial, participants using semaglutide lost a significant percentage of their body weight compared to those using a placebo.If you have Type 2 diabetes, one of the reasons you may be prescribed Ozempic is because it can help you lose weight.In a study where Ozempic was added to one or more diabetes pills, adults with type 2 diabetes weighing 197 pounds lost 12 pounds in one year on a 1 mg weekly dosage.Your healthcare provider will start you on a low dose, gradually increasing this until you reach a maintenance dose.Hemoglobin A1C reflects average blood sugar levels over the previous two to three months.Here are some stars who have admitted to taking the medication for weight loss and others who have vehemently denied taking it.This seems to be primarily related to severe GI side effects that lead to dehydration. This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. Low blood sugar also can occur if you delay or miss a meal or snack, exercise more than usual, drink alcohol, or cannot eat because of nausea or vomiting. This medicine does not cause hypoglycemia (low blood sugar). “We believe it will expand access and options for patients,” Dr. Jason Brett, principal US medical head for Novo Nordisk, told CNN in an interview. Altogether, about 1 in 8 US adults say they’re currently taking one of the medicines, according to data from health policy research group KFF. “If you gain muscle weight, your total weight change may not be as dramatic as you were expecting.” During menopause, women often become more insulin resistant, as estrogen levels lower and a pituitary hormone called FSH rises, which can also lead to weight gain. Sekhon says that when people who have had irregular menstrual cycles start using Ozempic, their cycles become very predictable, which makes managing fertility easier. Is Ozempic Indicated for Weight Loss in Non-Diabetic Individuals? She thinks about weight loss with the medication in terms of improving her health, rather than being able to fit into a smaller size dress, Schwartz previously told TODAY.com. Less than a fifth of large companies in the U.S. offer health insurance plans that cover weight-loss drugs like Wegovy, a 2024 survey found. In fact, Huntley said putting patients with prediabetes on GLP-1s for weight loss often prevented them from getting type 2 diabetes altogether. The key is to set realistic expectations and work closely with a healthcare provider to track progress and adjust treatment if needed. In the first 4 to 8 weeks, some people notice a small drop in weight. On average, they lost about 6% to 9% of their starting body weight. Are there non-prescription supplements to support weight loss alongside these medications? At TrimRx, our story began with a vision to help people embrace healthier lives by combining cutting-edge telehealth innovations with personalized, medically supervised weight loss solutions. To minimize side effects, both medications start at low doses with gradual increases. This is thought to be influenced by genetic factors and the metabolic effects of diabetes medications. GLP-1 stands for glucagon-like peptide-1, a natural hormone in the body that helps control blood sugar and appetite.When i started tirzepatide (zepbound) over 18 months ago, i experienced gi-related side effects like nausea and heartburn.While both Mounjaro and Ozempic are really diabetes drugs, they also can help you lose weight.In November 2024, the Biden administration proposed a change, redefining obesity as a chronic disease deserving treatment coverage.But these compounds are not regulated (which could make them dangerous), the prescribers are “not trained,” and the semaglutide dose is smaller, Dr. Musleh explains.While Ozempic was initially approved for type 2 diabetes, its potential for weight loss was evident from the early clinical trials.According to clinical studies, patients using Ozempic for diabetes management have reported substantial weight loss alongside improved glycemic control.Franklin has type 2 diabetes and takes Ozempic®.Paid spokesperson of Novo Nordisk.Ozempic relies upon your body’s own insulin to have this effect. Ozempic (the brand name for semaglutide) is a medicine made for adults with type 2 diabetes. But over the last few years, Ozempic has flooded the headlines as a prescription weight-loss drug (which it isn't, exactly — but more on that later) that was favored by celebs. In the 1990s, diet pills — including fen-phen, a combination of the drugs fenfluramine and phentermine — were popular. Weight-loss drugs been around for a while now, bouncing in and out of popularity. Ozempic should not be used by patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2. In animal studies, semaglutide caused thyroid tumors, including medullary thyroid carcinoma. Ozempic has a boxed warning for the risk of thyroid C cell tumors. Starting at a low dose helps reduce gastrointestinal discomfort. Because people tended to feel fuller for longer, they had fewer cravings and didn’t eat as much, losing weight. The drug has been on the lips of thousands of people looking to shed pounds. Most commercial insurance providers will cover some or all of the cost of Ozempic when used to treat type 2 diabetes or the drug may also be covered under Medicare Part D and Medicaid. So when doctors prescribe Ozempic for weight loss, it’s considered “off-label”. In addition to the high cost of the drugs, there have also been intermittent shortages of the drugs, which is also why some people have turned to compounding pharmaciesAt TrimRx, we believe in empowering individuals with the information they need to make informed health decisions.We encourage you to take our free assessment quiz to determine your eligibility for our prescription weight loss medications.Lastly, many experts and patients encourage people to consider Ozempic use from an ethical standpoint.The dose of this medicine will be different for different patients.(Ozempic and Wegovy are both the same molecule—semaglutide—and are made and sold by Novo Nordisk.)Recently, the FDA announced Ozempic can be used to reduce the risk of chronic kidney disease. Once you treat the disease, the patient should stay on the treatment that works long term. I get this question a lot from patients and providers. This is what we aim for with Penn State Health’s lifestyle program for obesity, Digital Weight Management. In Wegovy trials, participants most commonly reported gastrointestinal side effects along with headache and fatigue. Rare, but serious, side effects have been reported with semaglutide. Common semaglutide side effects include nausea and vomiting, diarrhea, and stomach pain. But a healthcare professional may prescribe it off-label if you need help managing your weight. Currently, the longest semaglutide trial followed people receiving Wegovy for up to 5 years. Gastroparesis symptoms, such as nausea, vomiting, and fullness after eating, are very similar to common semaglutide side effects. Join Voices for Kidney Health to support kidney healthcare policies. One major hurdle is health insurance coverage, which varies by provider. GLP-1 RAs act like a natural hormone that helps control blood sugar and digestion. However, they all carry warnings about possible serious side effects, including kidney damage and inflammation of the pancreas. Over time, too high sugar in the blood can damage multiple organs and weaken circulation. Figure 2. PRISMA flow diagram for included articles. In contrast, Wegovy, another formulation of semaglutide, was approved by the FDA in 2021 specifically for chronic weight management in adults. It is specifically indicated for the management of type 2 diabetes and is often prescribed off-label for weight loss. The short answer is no; Ozempic is not FDA-approved for weight loss. Research is still ongoing to learn more about the long-term safety of Ozempic when used for weight loss. For many people, the weight they lost may come back if they stop the medicine. Most side effects go away after a few weeks, but some people may have more serious problems like pancreatitis or gallbladder issues. It’s important to know that weight loss with Ozempic doesn’t happen overnight. Some people lose a small amount of weight, while others lose a significant amount. What are the differences between different types of weight loss medications? On the other hand, if the next dose is less than two days away, skip the missed dose and take the next scheduled dose.The Danish drugmaker’s popular weight loss medication is now indicated to reduce the risk of kidney failure and disease progression, as well as death due to cardiovascular disease.These mechanisms are similar to those observed in bariatric surgery, making it a powerful tool in the fight against obesity.Ozempic was already available for lowering the risk of major adverse cardiovascular events in patients with diabetes who have established cardiovascular disease and have obesity or overweight, with an initial body mass index (BMI) of 27 or greater.But if you stop using it, it’s possible to gain some (or all) of the weight back.To look at this, one recent study looked at weight loss and side effects in adults who were overweight or had obesity.At TrimRx, we believe in the power of personalized weight loss solutions that prioritize safety, effectiveness, and individualized care.Ozempic is making waves in weight management, but it wasn’t originally created for shedding pounds.Ozempic is approved for type 2 diabetes management, while Wegovy is specifically approved for weight management at higher dosages. Ozempic face before and after is a phrase many patients and medical professionals are searching these days—and for good reason. See Ozempic face before and after changes, understand facial volume loss due to GLP-1 meds, and explore expert-backed treatments for Ozempic face. Differential effects of glucagon-like peptide-1 receptor agonists on heart rate. Association of glucagon-like peptide-1 receptor agonist use with risk of gallbladder and biliary diseases. Many GLP-1 side effects are temporary and improve over time. Ozempic helps with weight loss by regulating appetite, enhancing satiety, and promoting stable blood sugar levels, which can lead to reduced calorie intake. Ozempic was first approved by the FDA in December 2017 for the treatment of type 2 diabetes. If you’re ready to take the next step in your weight loss journey, consider taking our free assessment quiz to see if you qualify for our personalized treatment options. If you are a Mayo Clinic patient, we will only use your protected health information as outlined in our Notice of Privacy Practices. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. They also may not be a good choice for people with certain types of kidney disease. In December 2025, the administration also introduced the BALANCE (Better Approaches to Lifestyle and Nutrition for Comprehensive hEalth) model, a five year CMS Innovation Center (CMMI) model that intends to expand access to obesity drugs in Medicaid and Medicare by negotiating lower GLP-1 prices with manufacturers. Unless Medicaid covers obesity medications, enrollees are unlikely to have access to them given the high out-of-pocket cost even at lower prices. Further, the recent announcements will not impact costs for Medicaid enrollees as they already pay little or no copays for prescription drugs, and the costs of purchasing drugs directly from manufacturers through TrumpRx will likely still be prohibitive for people on Medicaid who must have a low income to qualify for the program. While lower prices for state Medicaid programs could help alleviate cost concerns for states and result in expanded coverage of obesity drugs, how the new lower costs compare to the net prices state Medicaid programs currently pay and how states will respond amid tightening budget conditions remain unclear. The trial showed that people who took semaglutide lost almost 10 percent of their body weight on average compared to people who received a placebo. But unlike previous trials of semaglutide, the SELECT participants did not have a history of diabetes, the disease for which the drug was initially approved in 2017. The drug semaglutide, sold commercially as Ozempic or Wegovy, is well known for helping people lose significant amounts of weight quickly. Can somebody say Ozempic? “It’s like a Christmas miracle.”That’s what Robbie Williams, 50, said about taking “something like Ozempic” during an interview with The Times.He said in the 2023 interview that he shed over 25 pounds with the medication. “Trust me, anyone who was fat last year and is now skinny is on the wonder drug.” If you have a history of pancreatitis, make sure your healthcare team is aware.In general, many insurance plans cover Ozempic for the treatment of type 2 diabetes, but coverage for weight loss may be more limited.Ozempic is a powerful medication approved for managing Type 2 diabetes, and while it has shown impressive weight loss results, it is not officially sanctioned for obesity treatment.The FDA has also found that some versions use salt forms of semaglutide (semaglutide sodium and semaglutide acetate), which are not approved and may not work as expected because they have a different active ingredient.But the authors of both papers said they can't determine if the antidiabetic drugs cause eye complications until large clinical trials are done.A majority of people with cardiovascular disease do not have diabetes, adds Ania Jastreboff, MD, PhD, a Yale Medicine endocrinologist, who is an expert in obesity medicine and director of the Yale Obesity Research Center (Y-Weight).Researchers randomly assigned participants to take a daily pill containing 25 mg of semaglutide or a placebo. In some studies, participants using GLP-1s have lost an average of 10% to 15% of their body weight over a year. These medications slow down stomach emptying, keeping you feeling full longer. One of the reasons GLP-1 receptor agonists have gained so much attention is their ability to help with weight loss. The Wegovy pill showed roughly similar weight loss and side effects in clinical trials as the Wegovy shot, and will be available by prescription in the US in January, according to Novo Nordisk. The drug, which Novo Nordisk calls simply the Wegovy pill, uses the same active ingredient – semaglutide – that powers the original Wegovy, along with its sister drug for diabetes, Ozempic. These anti-diabetic drugs can help with the hormonal changes and weight. Still, there are many potential benefits of GLP-1s outside of weight loss or diabetes management, which are still being studied. Because of them, many of those who need them the most can't get the drugs. But as the popularity of the drugs skyrocketed, so too did issues of accessibility. Mounjaro was approved for type 2 diabetes in 2022, and Zepbound, which contains tirzepatide, the same active ingredient as in Mounjaro, was approved in 2023. Blood sugar markers showed a significant improvement for all doses of orforglipron compared to the placebo, and heart, inflammation, and blood pressure markers also improved. Clinical trials indicate that patients using Wegovy® achieve an average weight loss of approximately 15-18% over 68 weeks with healthy eating and exercise. As a weight loss doctor at the New Jersey Bariatric Center® a common question from patients is which medication offers the most weight loss. If you're concerned about your ability to lose weight and are at a weight that puts you at an increased risk for certain health complications, it’s worth talking to your doctor about options, including whether a semaglutide injection may work for you.