“We’re starting to finally get some research showing that people who have been on these medications, their health improves,” Gallagher says, and they’re able to go off medications for things like high blood pressure, high cholesterol and more. Lowering the cost of GLP-1s for people could have a significant impact on their health. GLP-1 medications, however, can help many people lose a significant amount of weight and lower their risks for these other conditions. “Fiber doesn’t increase fat burn but it helps control appetite.Her approach to healthy eating focuses on what to eat more of for better health versus what to restrict or eliminate in the diet.Phen24 includes two separate formulas tailored for different times of the day.Guar gum is present in certain dietary supplements and is an ingredient in some food products, especially gluten-free baked goods, because it helps bind and thicken these products.Although they have different formulations of Hydroxycut, including “stimulant-free” options, caffeine appears to be the main star of the show and it’s most potent ingredient.A review of guar gum looking at 11 randomised controlled trials for weight loss showed no benefit versus placebo.At the end of 12 weeks, it was noted that the HCA group lost significantly more weight than the placebo group (3.7 ± 3.1 kg versus 2.4 ± 2.9 kg).Cautionary Tales of Today's Biggest ScamsThey’re part of a whole lineup of drugs that can help you lose weight, including some that have been around for decades (or in one case, since 1959!). If you have any bad side effects that don’t go away or get worse, stop taking the appetite suppressant and talk to a healthcare professional. Keep track of your progress by journaling your hunger levels, food intake, weight changes, and any side effects you experience. If you’re in the early stages of weight loss, OTC appetite suppressants can provide great short-term support. “Temu maintains strict requirements for dietary supplements, requiring documentation such as HACCP certification and composition reports. This has enabled us to identify and ban a number of ads that have broken our rules, including several ads for ‘faux-zempic’ supplements that misleadingly claimed to produce effects similar to prescription-only weight-loss medicines.” The Advertising Standards Authority (ASA) rules state that products cannot say how much weight customers lose or how quickly, or from which part of the body - as this is something brands simply cannot predict. Also saw products listed for sale on online marketplaces which make unfounded claims to target certain areas of the body or be as effective as weight-loss jabs. It’s ideal for those who want to reduce emotional eating and late-night cravings while feeling energized and motivated throughout the day. For busy women balancing work, family, and fitness, Zotrim offers a natural path to appetite control without relying on synthetic compounds or caffeine overload. Zotrim is a time-tested, herbal-based appetite suppressant formulated to help users manage portion sizes, reduce unhealthy snacking, and feel fuller for longer. Click Here for the Lowest Price on Capsiplex and View Today’s Discounts This helps you pick a supplement that can suppress appetite and support your weight loss goals. Learn how to choose the right appetite suppressants for weight loss. By reducing appetite and cravings, PrimeShred helps you control your calorie intake and stay on track with your weight loss goals. The ingredients in PrimeShred boost fat burning and help keep your muscles intact. Achieve sustainable weight loss and confidence with Trimtone as your trusted ally.” NOW Foods Glucomannan Powder Some studies have used 900-1,200 milligrams daily in capsule form. It could interact with drugs or other supplements you take. Talk to your doctor before you use chamomile if you have any health conditions, take medication, or are pregnant or nursing. You can find it in capsules, tablets, liquid extracts, oils, or skin creams and ointments. Your doctor may suggest you avoid taking other medications or supplements within 2 hours of activated charcoal so that you can properly absorb them. With this supplement, you get two sets of capsules for the day and one for the nighttime. The active compound Coleus forskolin activates different enzymes in your body that will start Lipolysis. Forskolin is a true fat burner that can also carry appetite suppressant capabilities. As a result, you will keep losing weight for a long time before reaching a plateau. The overall result is that your diet will halt, and you will no longer lose weight. As with any supplement, it’s important to consult with a healthcare provider before starting any new regimen. As with any supplement, it’s important to consult with a healthcare professional before starting any new regimen. Individuals sensitive to caffeine should avoid taking the supplement within six hours of bedtime. Always talk to a healthcare professional before starting any new OTC weight loss medications that workplan. They help support your weight loss efforts, along with a healthy lifestyle. Some studies show elevated levels of lead in bone broths, which can be harmful to health if consumed in large amounts. This extra protein can also assist in building lean muscle mass, which in turn enables your body to burn more calories throughout the day. Table I and following paragraphs report a non-exhaustive list of dietary supplements with evidence supporting their use in weight loss. Though dietary ingredients may show certain effects in preclinical and clinical settings, the evidence may not be clinically significant in clinical trials 10-12. Almost 33.9% of adults attempting weight loss, largely young adults, women, and lower socioeconomic groups, use dietary supplements 7, 10. Based on the results seen thus far in this study, Plenity can potentially improve various aspects of body weight for at least 24 weeks. Evidence-based compounds that burn fat and suppress appetite. Risky supplements, like synephrine or bitter orange, got eliminated right away. People who need some extra help losing weight often don’t have these advantages going for them. Losing weight can be easy if you are young and pretty fit. Older adults who are having trouble losing weight. Do Fat Burners Melt Away Pounds? An Expert Weighs In Prescription weight loss drugs can be an effective treatment for obesity. The newest generation of weight loss drugs is changing the conversation about obesity. Depending on your overall health, some side effects may be more dangerous than the risks of being overweight. Doctors are studying new treatment strategies to help people lose weight and to stay at a healthy weight. Transparent Labs Body Recomp – Best for Body Recomposition Instant Knockout helps men leverage the natural fat-burning properties of testosterone, thanks to its inclusion of zinc and B-complex vitamins. Women who struggle to keep their fat oxidation high and their hunger cravings under control should opt for LeanBean. The test group also dropped triglycerides, blood sugar and cholesterol with no side effects reported. Since the product is relatively new, only one 8-week study has been done, but the results are promising. However, many of the products with these effects contain multiple herbal ingredients, and the role of bitter orange in these adverse effects cannot be isolated. Several small human studies have examined whether bitter orange is effective for weight loss . Studies have examined the effects of Irvingia gabonensis on weight loss to only a limited extent in humans. Irvingia gabonensis seed kernel extract has been proposed to promote weight loss by inhibiting adipogenesis, as demonstrated in vitro . While they reduce the desire to snack or overeat, they can’t replace essential nutrients your body needs to thrive. Whether you’re taking PhenQ, Phen24, or any other natural appetite suppressant, these tips will help you lose weight faster, more safely, and more sustainably in 2026. For example, chromium may alter insulin sensitivity, while caffeine may elevate blood pressure or heart rate. It also appears to affect the gut microbiome in a manner that may improve metabolism and support weight loss. However, the drug is also often prescribed off-label to moderate weight loss. And it is still a form of fat, which means that taking too much can cause weight gain and raise overall fat and cholesterol levels. Although a form of fat, MCT tends to be processed in the body more quickly than other forms of fat, and is less likely to be stored as fat in the body. As a result, some doctors have prescribed dapagliflozin as an off-label treatment for weight loss. Better oversight is desperately needed to make sure misleading products are taken off the market. Regulation of the supplement industry cuts across several regulators and government bodies but they are failing to keep pace with how quickly the industry has boomed and the types of products now sold. The consumer champion reported all its findings to the retailers - leading to more than 50 misleading weight-loss supplement listings being taken down. If products make medicinal claims, they can be considered medicines and will be regulated by Medicines Healthcare products Regulatory Agency (MHRA). For example, at Holland & Barrett, Acai Berry tablets were listed under the ‘fat burner’ section of the website. 13 Although it can assist with feelings of satiety, fiber overall is not a good supplement for weight loss but rather a healthy addition to a balanced diet that can promote a healthy weight overall. There are some studies linked to possible neurologic benefits of Acetyl l-carnitine however, there is limited research on weight loss. The idea behind caffeine for weight loss is based off of thermogenesis. Known as a complimentary alternative to medicine (CAM), herbs and extracts have been used to treat many different conditions and promote health and wellbeing but do they help us lose weight? Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. This information may not fit your specific health circumstances. Effect of dynamic stratified potassium supplementation in elderly patients with chronic heart failure and moderate to severe hypokalaemia-a randomised, controlled trial. If weight loss was easy, the majority of people would be walking around with washboard abs and glowing health reports from their doctors. She has extensive experience with dietary supplements and nutrition in particular. Research has shown that, when combined with a healthy diet and exercise regimen, orlistat can yield anywhere from 3 to 5 percent weight loss over the course of a few months. Some ingredients in OTC appetite suppressants, like glucomannan, green tea extract, and 5-HTP, may help reduce appetite. OTC appetite suppressants often have ingredients like caffeine and dietary fibers that make you feel fuller or reduce hunger for a short time. The U.S. Food and Drug Administration (FDA) is not permitted to regulate dietary supplements as it does medicines. Weight loss supplements, along with other types of dietary supplements, are sold online, in stores, and through TV ads. It is illegal, of course, to add prescription drugs to dietary supplements. Sibutramine is the most common drug found in contaminated weight loss supplements. However, all of these side effects tend to fade over time. Many products are also fortified with niacin during manufacturing. Niacin occurs naturally in many foods, including greens, meat, poultry, fish, and eggs, although in a fraction of the dose shown to achieve changes in cholesterol. Most people can get the niacin they need by eating a healthy diet. This amount is called the dietary reference intake (DRI), a term that is replacing the older and more familiar RDA (recommended dietary allowance). The company claims it can help with fat-burning and appetite control. It's marketed as a thermogenic energizer to help burn fat and boost metabolism. Its advanced formulation seems better equipped to deliver noticeable results when combined with a healthy diet and exercise routine. Zmyra also includes L-carnitine and ALA to potentially enhance fat metabolism. In my research, I've found that Zmyra offers a more potent and well-rounded fat-burning formula. Phentermine by itself (Adipex-P, Lomaira) also is used for weight loss. It affects the way your body absorbs fat. But practicing healthy lifestyle habits may help limit weight gain. But losing 5% to 10% of your total weight and keeping it off can have important health benefits. The combination of weight-loss medicine and lifestyle changes leads to greater weight loss than do lifestyle changes alone. The proposed mechanism of action involves an increase in the metabolic rate and stimulation of fat burning.With alli, each meal must be within your fat target to minimize the chances of diet-related side effects — generally, that’s between 12 and 18 grams of fat per meal.Before you get a weight loss drug prescription, tell your doctor about your medical history.Taking oral aloe can lead to side effects such as abdominal cramping, diarrhea, electrolyte disturbances, and decreases in potassium.Manufacturers are permitted to say, for example, that a supplement promotes health or supports a body part or function (like heart health or the immune system).With its natural, science-backed formula, Puravive is the perfect partner for lasting weight loss.Some of these are approved for weight loss, while others are used off-label.But off-label prescriptions for newer weight loss drugs have become so common they've contributed to shortages of the drugs. You can get them from supplements or from fermented foods like kefir, sauerkraut and apple cider vinegar. Adults should not consume more than 350 mg per day of magnesium in a supplement, according to the NIH. You can find out if you’re magnesium deficient by asking your health care provider to run labs to check your magnesium level. Magnesium deficiency is more prevalent in people who have obesity, diabetes and metabolic syndrome, and it has been linked to chronic inflammation. The chromium and L-carnitine seem to target abdominal fat stores specifically. I found Zmyra especially effective for stubborn belly fat. The formula tackles appetite, metabolism, and fat-burning all at once. The effects of long-term chamomile use aren't known. For some people, chamomile can cause side effects that range from mild to severe. You usually take chamomile capsules with a full glass of water at your preferred time(s) of day. Best Weight Loss Pills in 2025: Top 9 Supplements That Work If you are thinking about trying an OTC weight-loss product, talk to your doctor first. These products have not been proven to be safe or effective. The only over-the-counter weight-loss product approved by the U.S. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. We only recommend products or services that we trust and believe will add value to our readers. One of the most challenging aspects of losing weight is avoiding your bad-but-delicious food cravings.This growth shows that more people are turning to accessible, over-the-counter appetite suppressants and doctor-prescribed solutions to manage weight safely and effectively.Natural Medicines, an independent group that analyzes research on supplements, says there isn't enough reliable evidence to rate it.Zmyra's ability to promote sustainable weight loss without harsh side effects sets it apart from other supplements.Hormonal changes, such as menopause, can make weight loss more challenging for women as they age.A systematic review published in the International Journal of Reproductive BioMedicine evaluated 23 animal studies and four human studies.Hourglass Fit is one of the best natural appetite suppressant supplements for women in 2026, offering a targeted and thoughtful approach to weight loss.It depends on the exact medication, but weight-loss medications typically work by suppressing your appetite, increasing feelings of fullness, or both. Over-the-counter (OTC) diet pills are weight-loss supplements that can be purchased without a prescription. We’ve carefully researched and reviewed the best OTC diet pills for weight loss, focusing on formulas backed by science and real user results. If you’re thinking about taking a dietary supplement to help you lose weight, here are some things you should know. Taking a hunger suppressant may be unsafe for those who are a healthy weight or are underweight. #19. NatureWise CLA 1250 – Best Appetite Suppressant with CLA Support D'Elia, L., Barba, G., Cappuccio, F. P., and Strazzullo, P. Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies.If you are sensitive to caffeine, you're more likely to have side effects when taking an appetite suppressant that contains stimulants.But there are no firm conclusions about their effects on human health.With so many options on the market, identifying the top OTC weight loss products can be challenging.Tell your doctor about any other prescription and over-the-counter medicines, or natural health products you are taking.It’s common in fat burner supplements but can cause negative effects.Individuals seeking appetite suppressant pills and effective weight loss supplements should consult healthcare professionals for current, safe, and approved options available over the counter.Here are several lifestyle strategies, across three different domains (diet, exercise, and stress management), that may help you reach your weight goals. A review on curcumin and obesity suggests that curcumin can lower levels of inflammatory markers that are often elevated in individuals carrying excess weight, thereby addressing one of the obstacles to effective weight loss. That’s why it’s essential to discuss the potential benefits and drawbacks for your individual health and weight goals with your healthcare provider before you begin taking any supplements. According to the FDA, supplements may interact with medications, have negative effects on your health if you have an underlying medical condition, or may simply not be a fit for you. An overall lack of oversight leads to issues, with one concerning study showing that out of 30 weight-loss-supporting supplements, 25 had labels that did not accurately reflect what was present in the supplements. Food and Drug Administration (FDA) does not vet dietary supplements for safety and effectiveness before they are sold to the public. Additionally, the FDA does not regulate supplements as strictly as prescription medications, meaning that some ingredients may be untested for safety and efficacy. Users should be aware that the results may not be immediate, and long-term weight loss requires sustained effort and commitment. The effectiveness of over-the-counter weight loss pills can vary widely from person to person, and some might not experience significant results. It’s important to understand that while these products can offer support, they are not a substitute for a healthy diet and exercise. They usually contain ingredients that claim to boost metabolism, suppress appetite, or prevent fat absorption. Always consult your physician before taking any weight loss pills, especially if you fall into one of these categories. However, some individuals may experience mild, temporary side effects, particularly during the first few days of use. By keeping your brain chemistry stable while you’re dieting, hunger suppressants make the weight loss process smoother and more enjoyable. Over time, this leads to more mindful, structured eating habits, better portion control, and a more sustainable weight loss experience—without feeling deprived. Many individuals dealing with obesity or weight gain don’t just overeat—they eat impulsively, emotionally, or at odd hours. Treatment of obesity is therefore of major significance for researchers around the world. Excessive weight gain is considered a multifactorial phenomenon that involves variably interacting biological, behavioral, genetic, and environmental factors 1-4. Dietary supplements are considered an attractive alternative to traditional therapy due to their low toxicity profile and their accessibility to the general population. This dual-action formula of appetite control and energy enhancement means you can burn fat faster and stay more active, even when cutting calories—without the usual fatigue that comes with dieting. Appetite suppressant supplements have surged in popularity in 2026—and for good reason. We favored transparent companies that disclose full ingredient labels, avoid proprietary blends, and manufacture products in FDA-approved, GMP-certified facilities. Still, we always recommend consulting a healthcare provider before starting any new supplement. After all, there are many products on the market that claim to control cravings and curb appetite — and ultimately, help with weight loss.BMI, a ratio of your height versus weight, was also decreased by 2.1 kg/m2 in the GLOW study Plenity group versus 1.5 kg/m2 in the placebo group.A simple trick that supposedly works in days?Pregnant women and women who are breastfeeding should not use DMSO, since little is known about its possible effects on the fetus or infant.Over the past few years, GLP-1 medications for weight loss — such as semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) — have surged in popularity, including among older adults.If a meal is missed or contains no fat, skip that dose.Decreased intracellular calcium concentrations, in turn, might increase fat breakdown and discourage fat accumulation in these cells .Some weight reduction supplements also have elements that might increase energy and attention, allowing you to exercise more effectively and remain motivated. The Office of Dietary Supplements (ODS) at the National Institutes of Health (NIH) has strengthened and enhanced understanding and knowledge of dietary supplements through the evaluation of scientific information, supporting scientific research and public education . Moreover, interventional approaches such as surgery, pharmacological therapy and dietary supplements have also been developed 7, 9. Indeed, several solutions have been proposed, such as following a healthy lifestyle, following eating plans for weight loss, and exercising. These products aim to provide convenient, fast-acting solutions by delivering ingredients directly into the body. The world of over-the-counter (OTC) weight loss products is constantly evolving, with innovations hitting the market to address a variety of needs. Finding the right OTC weight loss products is all about accessibility and convenience. Fat burners contain ingredients that stimulate the body’s natural fat-burning processes. AOMs may counter the effects of metabolic adaptation and prevent weight regain. Medicare does not cover weight loss drugs. Insurance coverage varies and will affect many patients’ choices about going on weight loss medications. Beta-glucan can help a person feel full for longer, as its digests slowly, contributing to weight loss. The Garden of Life Raw Organic Fit Protein Powder is a plant-based protein powder formulated to support weight loss. We tested this weight loss supplement and found it effective. This may help reduce cravings and promote feelings of fullness, making it easier to manage one’s appetite and potentially support weight loss. This shows why it’s essential to talk to a doctor before using any OTC weight loss medications that work. Orlistat, found in Alli, is a common ingredient for weight loss. The FDA ensures that OTC weight loss medications that work are safe and effective. GLP-1 agonists, such as Wegovy, Zepbound, and Saxenda, are the most effective for weight loss. OTC and prescription weight loss drugs differ in their strength and the level of oversight they receive. But does it really work as well as Ozempic and other GLP-1 medications to help you lose weight and keep your blood sugar levels in check? 25 great ways to win the belly-fat battle Exercising and eating less sugar are a few ways to reduce belly fat. Rachel Nania is an award-winning health editor and writer at AARP.org, who covers a range of topics including diseases and treatments. Increased muscle mass can ultimately lead to improved body composition and fat loss by increasing resting energy expenditure.” Many people take creatine supplements to lose weight and increase their lean muscle mass. Chromium picolinate is another supplement that may aid in weight loss. Although this study focused on elderberry juice specifically, elderberry supplements are also widely available in the U.S. Side effects may include headache, insomnia, nervousness, irritability, frequent urination, fast heartbeat and muscle tremors, according to the Mayo Clinic. The National Institutes of Health recommends no more than 500 mg a day. In high doses, caffeine can cause vomiting, heart palpitations and seizures. Your body may not absorb important vitamins, minerals, and other nutrients from food while you are using orlistat. Eating fewer fatty foods can reduce this effect. Many people regain most of the weight within 2 years after they stop using it. But not everyone loses weight while taking it. Orlistat works by slowing the absorption of fat in the intestine by about 30%. These drugs are approved by the FDA for people with obesity and for people who are overweight and have certain medical conditions. An appetite suppressant is a weight loss drug that works by making you feel less hungry or making you feel fuller when you eat. If you are vegetarian or vegan, choosing over the counter or medications for weight loss can be difficult as gelatin is a common ingredient in pill capsules. More detailed information about each of the above weight loss medications can be found in the latest edition of Obesity Medicine Association’s Obesity Algorithm®. Setmelanotide is a melanocortin-4 receptor agonist indicated for chronic weight management in adult and pediatric patients six years and older, with obesity due to certain rare genetic disorders. Dosage is one 120 mg capsule three times a day with each main meal containing fat (during or up to one hour after the meal). Undigested fat is then passed through the body. Among the many ingredients presented in this study, chitosan and green tea showed promising results with limited side effects.In one study, 75% of people taking phentermine-topiramate lost at least 5% of their body weight after a year.Because obesity can be a risk factor for GERD, a healthcare professional could suggest weight-loss surgery as an option for treatment.CLA supplements are made by chemically changing natural sources of linoleic acid.But AMPK can also influence body fat composition, and it plays a critical role in regulating your appetite.The other got a supplement that had raspberry ketone, caffeine, bitter orange, ginger and garlic root extract. Weight loss supplements are considered as pills or liquids that help with weight loss. Melissa Mitri is a registered dietitian-nutritionist, weight loss specialist, and expert health writer with over 18 years of experience in the health and wellness industry. Working alongside a healthcare professional can reduce the risk of weight regain after coming off of Plenity and ensure you achieve the best results possible with the least side effects. When combined with a healthy diet and exercise plan, Plenity has the potential to complement your weight loss results. BMI, a ratio of your height versus weight, was also decreased by 2.1 kg/m2 in the GLOW study Plenity group versus 1.5 kg/m2 in the placebo group. Additionally, dietary supplements are loosely regulated and don’t have to be safety tested before being sold. To help provide clarity around weight loss supplements, we asked three registered dietitians to share the ones they recommend to their clients. It’s also important to note that clinical research and safety data on weight loss supplements varies, and clinical guidelines don’t generally include weight loss supplements. Supplements alone are not a comprehensive approach to healthy weight loss, but they may help enhance weight loss due to other lifestyle changes, such as improved eating and exercise habits. Some, like green tea extract, may have a more direct effect by modestly increasing metabolism and fat oxidation. It works by blocking the enzyme that breaks down fats consumed through food, inhibiting the absorption of dietary fats. Adults with migraines and obesity are good candidates for this weight-loss medication. It was originally used as a short-term medication to jump-start weight loss, but now newer medical guidelines have added it to long-term therapy. Phentermine is the oldest and most widely used weight loss medication. Side effects include nausea, diarrhea, constipation, vomiting, headache, decreased appetite, dyspepsia, fatigue, dizziness, abdominal pain, increased lipase, and renal insufficiency. Be sure to consume enough calories from a variety of food groups each day to help you feel energized and avoid any nutrient deficiencies. Also, while taking an OTC appetite suppressant, you should still maintain a healthy, balanced diet. If you have an underlying health condition, you should talk to your doctor before adding an appetite suppressant to your diet. As a result, appetite suppressants are generally safe and do not often lead to side effects. Drinking black coffee is your best bet to gain the drink’s health benefits without consuming unnecessary calories. “By that I mean it helps liberate fatty acids from our fatty tissues, especially for cardiovascular exercise. It can give you a jolt of energy, boost your metabolism and increase fat breakdown, Willis says. Talk to your health care provider before taking them. Oral forms of aloe are added to herbal weight-loss products. Some research suggests that it may promote slight weight loss. But taking chitosan without reducing caloric intake doesn’t appear to cause weight loss. Some research suggests that combining chitosan with a calorie-restricted diet might result in a small amount of weight loss. So, which one of the best OTC appetite suppressant supplements depends on your eating habits and what is bothering you. If you are already losing weight and want some help suppressing your appetite, stick to Lean Optimizer or PhenQ. If you have already tried all sorts of supplements and diets with no luck, then the Official HCG Diet might be something for you. Your brain won’t want you to be on a diet, so it releases hormones that make you hungry and prevent you from burning fat. Falling back into old habits that prevent you from losing weight is also called the yo-yo effect. They can block fat absorption, suppress appetite, or boost metabolism. While these OTC options might offer some benefits, they’re not a replacement for a healthy lifestyle. I realised I’m not alone, as many Americans face weight issues. No matter your experience level, pretty much every attribute you’re likely to train in the gym can be improved with a little caffeine, according to the International Society of Sports Nutrition’s position stand on caffeine10. Mental energy, physical energy, workout energy, gaming energy, dieting energy… caffeine has been shown time and time again to boost them all. And BCAAs tend to come in a wider range of flavors than protein supplements, including many naturally-sweetened varieties that our reviewers of the best BCAA supplements raved about. While a healthy diet and regular exercise are the cornerstones of any successful weight loss plan, some people may turn to weight loss drugs for an extra boost. It will also limit the effects of the fat-burning processes in your body. Supplements that are based on all-natural ingredients can be healthy, though we would recommend checking with your doctor before you start taking anything, especially anything with a high concentration of caffeine. Green Tea – Helps you decrease your body weight by increasing metabolism and the levels of hormones that tell your body to break down fat. TrimTone literally tells your body to burn stubborn fat as a source of energy, unlocking your weight loss potential. All of the ingredients in the PrimeShred weight loss supplement are carefully selected for their fat-burning, appetite-suppressing, and energy-boosting properties. When exploring weight loss supplements, it is crucial to understand that more scientific evidence is needed to confirm these effects. Very early studies suggest it might be helpful, but other evidence shows it doesn't work. This is a popular supplement that contains chemicals found in a fatty acid called linoleic acid. Chitosan usually causes no side effects, but some people get an upset stomach or constipation. Natural Medicines, an independent group that analyzes research on supplements, says there isn't enough reliable evidence to rate it. Avoid processed foods, sugary snacks, and excessive calories, undermining your weight loss efforts. Focus on a diet rich in lean proteins, whole grains, healthy fats, and plenty of fruits and vegetables. Second, pair your weight loss pills with a balanced diet. What are the side effects of weight loss drugs? “But they tend to be mild.” Orlistat has some unique (and unpleasant) side effects, like gas, oily or loose stools, and oily spotting (since your body has to get rid of the excess fat that it's not absorbing). One study found that semaglutide can lead to an average 15% weight loss in a little over a year. If you’ve seen other weight-loss products on the shelf at stores, they may be a waste of money at best — and at worst, dangerous to your health. Digestive issues including nausea, vomiting, abdominal pain, and diarrhea can occur, in addition to headaches and fatigue. In 2014, the FDA approved the drug (under the name Saxenda) as a medication for chronic weight control. Dapagliflozin improves blood sugar control by aiding the body in removing sugar (and the calories that come with it) from the bloodstream and through the kidneys via urine. Another diabetes medication given the green light by the FDA in 2014, dapaliflozin was later approved to help patients suffering from heart failure and chronic kidney disease. Similar side effects have been reported with Contrave, as well as some digestive issues, such as nausea, vomiting and constipation. By increasing the body’s calorie-burning potential, these products help users burn more energy throughout the day, even at rest. Unlike prescription medications, OTC diet pills typically use natural or plant-based ingredients and are intended for everyday use when combined with healthy habits. This BMI indicates obesity, a diagnosis that warrants weight loss. Therefore, anyone who is overweight may benefit from the effects of these supplements. Most reported adverse effects are minor, consisting mainly of gastrointestinal disturbances, such as abdominal discomfort and pain, constipation, diarrhea, loose stools, nausea, vomiting, and dyspepsia 3,109,111,113,115,116.A small study found that a supplement led to a 4.2-pound OTC weight loss medications that work over an eight-week period.Such claims are not permitted under current advertising and health claim rules.Remember, choosing OTC weight loss products should be a careful decision.“Patients aren’t always forthcoming about what supplements they’re taking.In reality, sustainable weight loss takes time and effort.2) Decreasing nutrient absorption, especially fat, so total calorie intake dropsWith its day and night formulas, Phen24 is marketed as a 24-hour fat-burning system, all but guaranteed to help kick metabolism into gear, especially when it starts to slow down with age.It's released when you eat and tells your body to make insulin to control your blood sugar. Caffeine is an incredibly powerful weight loss supplement, when used judiciously – too much can cause jitters and sleeplessness. The two plant extracts in Meratrim are supposed to cut back on the amount of fat snagged from the blood, assist in fat-burning processes, and make it more difficult for fat cells to multiply. When data was correlated from 11 studies, subjects taking Alli lost up to 6 more pounds than those taking placebo pills. Let’s take a look at some of the FDA-approved weight loss supplements on the market. The FDA has approved a small handful of weight loss supplements as medications but, in most cases, you have to qualify to get a prescription which is not always an easy feat. The Dietary Supplement Health and Education Act of 1994 placed herbal remedies in the same category as dietary supplements. The real challenge is knowing which supplements actually work and which are just hype. Losing weight isn’t easy—especially with so many over-the-counter (OTC) diet pills promising quick results. Get health information and other updates by email A one-month supply of some of the best over-the-counter appetite suppressant supplements can cost anywhere from $60 to $100. Weight loss and absence of side effects were reported for both ingredients by meta-analysis. Obesity is a prevalent nutritional disease and a significant public health issue in industrialized countries. Several proof-of-concept clinical trials have established a dose-dependent reduction in glucose absorption after supplementation with white kidney bean. It may act as a decongestant and appetite suppressant and induce significant weight loss. It is a natural function in your body because your body and your brain won’t want you to be on a diet. Lean Optimizer is based on the principle that you will eventually reach a plateau where you no longer lose weight. In the fifties, Dr. Simeon discovered that injecting HCG into obese people could make them lose weight. At the same time, it is incredibly healthy and contains many nutrients. Typically, you will crave sugar until your body’s cells get enough of it. By improving sleep quality, PhenQ PM helps regulate appetite-related hormones, which play a key role in weight gain and late-night snacking. PhenQ PM stands out as a night-time fat burner designed to work while you sleep. This makes it suitable for daily use, even for women who are sensitive to caffeine. One of the standout features of Capsiplex TRIM is its use of natural, clinically studied ingredients that promote thermogenesis without causing jitters or crashes. Symptoms of overdose may include the following: Nieman et al. performed a single-blinded, trial in which 76 overweight/obese participants were randomized to receive 50 grams of chia seed daily or placebo. This was a double-blind, placebo-controlled trial in which 102 natives of Cameroon with a BMI of 26 to 40 kg/m2 were randomized to receive 150 mg of Irvingia gabonensis or placebo daily for ten weeks. A second article by Ngondi et al. also examined the effects of Irvingia gabonensis on weight loss. There was no change in percent body fat for both the treatment and placebo groups . Subjects were randomly assigned to receive 350 mg of Irvingia gabonensis seed extract or placebo for 4 weeks. From natural fat burners to appetite suppressants, you’ll learn which ingredients truly support healthy, sustainable weight loss and how they work in real life. To date, most of the small clinical trials only show small, statistically non-significant weight loss in overweight adults or adults with obesity. A meta-analysis of 876 subjects showed that curcumin supplementation at a dose of at least 1,000 milligrams (mg) per day taken for at least eight weeks was linked to a reduction in body weight (~1/14 kg) and body mass index (BMI) (a reduction of 0.48 kg/m2). In the context of weight loss, curcumin supplements may play a supportive role by potentially increasing metabolism and aiding in the body’s fat-burning processes, according to a meta-analysis involving people with metabolic syndrome and related disorders. Among the countless dietary supplements available, there are some that have data supporting their potential benefits for weight loss. When paired with healthy eating and fitness choices, appetite suppressants may help increase our odds of success. This explanation sheds light on why so many people are unable to stick with their weight-loss goals. While things like weight-loss apps help us collect data and track progress and meal delivery services ensure that consistency is convenient, appetite suppressants help preserve our resolve. Weight loss in underserved patients - A cluster-randomized trial. Similar to the other GLP-1s, there is a version approved for weight loss (Saxenda) and one for treatment of type 2 diabetes (Victoza). When people paired liraglutide with diet and exercise, liraglutide leads to an average weight loss of 5% to 10% in about a year. Liraglutide, which comes as a daily injection, was the first prescription GLP-1 FDA-approved for weight loss. But “although tirzepatide kind of outpaces semaglutide in head-to-head trials, both of them are very effective,” says Kushner. Those in the Phaseolus vulgaris group also experienced a significantly greater reduction in fat mass, adipose tissue thickness, and waist–hip–thigh circumference.While insurance generally covers GLP-1 agonists for diabetes control, it's less common when they're prescribed for weight management.As Wegovy, it received FDA approval specifically for the treatment of obesity in 2021.Much to our dismay, studies on caffeine did not show any promising results for weight loss but there was some improvement when it was combined with the catechins in green tea.Consulting a healthcare professional can help manage potential risks and better understand what to expect when using these supplements.This schedule maximizes glucomannan’s appetite-suppressing effects throughout the day.Whether managing cravings during the day or controlling late-night snacking, Aqua Sculpt’s formula works around the clock to keep you on track.Ingredients that contain caffeine, such as green tea extract, give your body energy and help reduce cravings, decreasing your desire to overeat. Healthcare providers also use body mass index (BMI) as a factor. Your healthcare provider can help you understand the pros and cons of this treatment and if it’s right for you. These drugs can be the answer to years of health challenges for many people. Losing weight isn’t always as simple as eating less and exercising more. Others work by changing how you absorb fat or burn calories. There’s a reason why 85% of American adults consume caffeine on a daily basis, either from coffee or from supplements containing caffeine anhydrous. The researchers found a “large decrease in DOMS,” or delayed-onset muscle soreness, in subjects taking BCAAs after exercise compared to placebo. Both are important in their own ways, but registered dietitian Destini Moody says you should prioritize soluble fiber if your goal is weight loss. Get the latest in health news delivered to your inbox! As a result, the quality and content of these products can vary. As with other supplements, DHEA is not regulated by the FDA. Be aware that higher doses or longer-term use of DHEA may increase the risk of serious side effects. You can also find it in common water filters and in over-the-counter products like toothpaste and face wash. They can let you know about any potential side effects, risks, or interactions that might happen if you take them at the same time as activated charcoal. Be sure to tell your doctor about any medications, vitamins, or supplements you're taking, even the natural ones. But like all medications and supplements, it can come with risks, particularly if you use it for a long time without instructions from your doctor. Activated charcoal is generally considered safe when given on a short-term basis by a health professional for an overdose or poisoning. A popular amino acid that plays a significant role in fat metabolism, facilitating the conversion of fat into energy. Fat burners aim to increase energy expenditure, enabling the body to burn more calories. These products work by reducing the feeling of hunger, making it easier for individuals to consume fewer calories. For example, some are approved by the FDA for up to 12 weeks. Some weight management medications are designed for short-term use and others for long-term use. A treatment plan for obesity can comprise multiple forms of treatment, including medications, diet, exercise, and/or surgery. The following medications can potentially cause variable weight gain in some individuals. They’re typically reserved for individuals with a high BMI or obesity-related conditions and must be prescribed by a doctor. Natural suppressants are ideal for women and men who prefer gentle, stimulant-free solutions or want to avoid side effects. As with any supplement, it’s essential to combine its use with a healthy diet and regular exercise, and consult with a healthcare professional before starting any new regimen. By targeting appetite suppression, thermogenesis, and mood support, it offers a comprehensive approach to weight management. Well, the amount of research on capsaicin is still small, as is the amount of weight loss. Excessive caffeine intake can lead to side effects like jitters, anxiety, and headache, as well as creating tolerance, reducing its potential benefits. The U.S. Food & Drug Administration recommends capping caffeine at 400 milligrams per day, or the amount in 24 to 36 ounces of coffee. There is less research on caffeine supplements, however, and it’s easy to get too much this way. Semaglutide works by mimicking a hormone named “GLP-1” that tells the body that it’s full. Other forms of semaglutide, meanwhile, have been prescribed off-label for weight-loss treatment as well. In 2021, a higher-dose form of the drug, branded as Wegovy, was approved by the FDA for weight management. The drug is a stimulant, and is thought to help with weight by suppressing the appetite. Let's dig into what's really going on with the gelatin weight loss trick—what it is, why it's everywhere right now, and whether it actually works. Consumers and healthcare professionals alike should stay informed, practise due diligence, and prioritise evidence-based products over eye-catching claims. In the UK, any health claims made about supplements must be backed by scientific evidence and appear on the government-maintained health claims register. Exposed a wave of dubious and supposed weight-loss supplements sold online, being marketed with unproven claims. In a significant move in the online medicine market, more than 50 misleading weight-loss supplements online have been removed from major platforms. It's a good idea to choose supplements that have been researched and shown to be effective, or those that are recommended by weight loss experts like registered dietitians or obesity medicine physicians. Additionally, caffeine and other stimulants commonly found in weight loss supplements, like bitter orange and yohimbe, may worsen heart problems by increasing blood pressure and heart rate. In some cases, supplements, when combined with a healthy lifestyle, may help support your weight loss journey. However, supplements may compliment a weight loss plan when combined with a healthy diet, regular exercise, and plenty of sleep. “We develop innovative tools to prevent unsafe products from being listed. Compared claims on the product listings to approved and on-hold claims for each of the active ingredients listed, ASA rules and guidance, and general principles agreed between certain EU Member States (including the UK pre-Brexit). Looked at online product listings of food supplements across a range of popular retailers, including online marketplaces. The consumer champion will also be hosting a live podcast on 22nd January discussing ‘can we get healthier as we age? “Not only does this make it impossible for shoppers to trust the claims they see online but it also means people could be wasting their hard-earned cash on products which just don’t live up to the claims. The better your glucose is controlled, the better chances you have of losing weight. One of the supplement’s main functions is to trigger an important enzyme, AMPK (activated protein kinase), that controls your metabolism, the process in which your body turns what you eat and drink into energy. However, it’s been shown to help people lose some weight and lower their blood sugar levels. It claims to help burn fat, stop fat production, suppress appetite, and boost energy. While other supplements I've tried had some effect, none matched Zmyra's all-around performance. After a few weeks, I saw visible changes in my midsection. She enjoys cooking, reading, writing fiction, and weightlifting. Also, ask your healthcare provider if the supplement could interfere with any medications you’re currently taking. Look for third-party tested or certified products so you know the label is accurate and the product is free of contaminants. Check the ingredients to be sure they don't contain anything you're allergic to. Finally, you'll want to be sure that the supplements you choose are safe to take. Codeage supplements are vegan and third-party tested for the presence of contaminants like heavy metals. Res Prebeet Energy Prebiotic is a drink mix that's designed to support digestive health, particularly in people taking GLP-1 medications. Also, it’s important to note that omega-3 fish oil supplements aren't vegan-friendly. This creatine is roughly $0.44 per serving, which is more expensive than similar creatine supplements, but it’s vegan and I believe the quality and safety make it worth the extra expense. There are various meta-analyses of ivermectin and COVID-19 studies. Some in vitro studies show broad-spectrum antiviral activity and inhibition of SARS-CoV-2, but this hasn’t been replicated in human studies.4 Since the COVID-19 pandemic, numerous studies on the potential use of ivermectin for treatment have been conducted. Both states and their respective acts indicate that “ivermectin is suitable for human use and may be sold or purchased as an over-the-counter medication in this state without a prescription or consultation with a health care professional.”3 Guar gum is a soluble dietary fiber derived from seeds of the Indian cluster bean Cyamopsis tetragonolobus 16,174. Green tea (Camellia sinensis) is a popular beverage consumed worldwide that has several purported health benefits . Green coffee bean extract appears to be well tolerated, but its safety has not been rigorously studied. Green coffee beans contain caffeine (see section on caffeine above) , although decaffeinated forms are available . Chromium plays a significant role in the metabolism of amino acids, glucose, and lipids though its effects on insulin. It is currently available over the counter for treatment of conditions like obesity, hypertension and hypercholesterolemia . Vitamin D helps the body absorb calcium after conversion to calcitriol in the kidneys. This is another common ingredient because green tea helps burn calories and reduce the fat you absorb from food. Since fat burner supplements aren’t FDA-approved, you can’t always be sure what’s inside. Instead, they can work by helping weight loss in other ways. Studies have shown that fat burner supplements might not work the way you want them to. Even though more research is needed into how long weight loss results last with Plenity, we still believe it to be a more natural, safer weight loss pill than others on the market. In the GLOW study, those taking Plenity reduced their waist circumference by 6.7 centimeters versus only 5.0 centimeters in the placebo group. Plenity can be a useful weight loss ally when combined with a reduced-calorie diet and exercise plan. Even though it’s a capsule, it’s considered a weight loss “device” by the FDA, as it’s not absorbed in the digestive tract. Fiber in general has also been studied to help with weight loss,” says Christa Brown, RDN, a licensed dietitian and diabetes expert in Woodbridge, New Jersey. However, a healthy and sustainable weight loss rate is 2lbs per week, depending on how much you eat. They typically either burn fat, suppress your appetite, block carbs, etc… PhenQ takes a unique approach to weight loss that aims to target multiple angles at the same. PhenQ is a powerful 5-in-1 weight loss pill that works as an appetite suppressant, fat burner, and metabolism booster. Reisin, E., Abel, R., Modan, M., Silverberg, D. S., Eliahou, H. E., and Modan, B. Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. Siani, A., Strazzullo, P., Russo, L., Guglielmi, S., Iacoviello, L., Ferrara, L. A., and Mancini, M. Controlled trial of long term oral potassium supplements in patients with mild hypertension. Obel, A. O. Placebo-controlled trial of potassium supplements in black patients with mild essential hypertension. The role of glucose-insulin-potassium revisited in a randomized, placebo-controlled study. Results from phase 1 of the trials of hypertension prevention (TOHP). Certain individuals should be extra cautious—or avoid these supplements altogether. To minimize issues, start with the lowest recommended dose and avoid combining products that contain stimulants. These symptoms usually subside as your body adjusts to the supplement. Before starting any appetite suppressant or diet pill, especially if you’re seeking strong OTC options in 2026, consider the following side effects, risk factors, and important medical precautions. Make sure the supplements you choose fit comfortably within your budget. If you have a significant amount of weight to lose, you may want to continue using a supplement for months or even years. If other supplements aren't third-party tested, you can check on their website to see if they have a rigorous in-house testing protocol or if they share their lab reports publicly. Weight loss supplements are a broad category, including herbal supplements, prebiotics and probiotics, protein powders, meal replacements, and more. I also aimed to include mostly third-party tested supplements at a variety of price points across various product types. Appetite suppressants are a type of weight-loss medication designed to help people with obesity control their hunger and achieve their health goals. There are a handful that are backed by science to support minimal amounts of weight loss, but they can’t stand in for healthy habits like a nutrient-rich diet and regular movement. A 2023 review and meta-analysis found just about a one pound difference between adults with overweight and obesity taking capsaicin compared to controls. It blocks the enzyme responsible for breaking down fats in the intestine, leading to approximately 25% of consumed fat being excreted undigested. Garcinia Cambogia Extra is a compelling choice for those seeking the best over-the-counter appetite suppressant that also aids in fat reduction. Garcinia Cambogia Extra is a standout among over-the-counter (OTC) appetite suppressant pills, offering a dual-action formula that targets both fat storage and hunger cravings.