Bariatric surgery should be considered as part of a comprehensive multidisciplinary treatment program taking into account the individual’s situation and treatment goals. Table adapted from Markovic (2022) and Draft Clinical Practice Guidelines for the Management of Overweight and Obesity for Adults, Adolescents and Children in Australia 2024 (based on Walmsley et al (2023) with information on Tirzepatide from Lingvay et al (2024) and Jastreboff et al (2022). Citizen petition to remove prescription orlistat from the market. All articles are reviewed and approved by Dr. Diana Zuckerman and other senior staff. As a result, Alli + diet + exercise seem to be more effective than diet + exercise alone. You also can get orlistat in a reduced-strength form without a prescription (Alli). Common side effects include nausea, headache and constipation. Bupropion-naltrexone can raise blood pressure. Most prescription weight-loss drugs work by making you feel less hungry or fuller. They may switch you to a different weight-loss drug. Currently available long-term anti-obesity medications for adults include orlistat, naltrexone/bupropion (NAL/BUP) extended release (ER), liraglutide, phentermine/topiramate ER, semaglutide, and tirzepatide (Table 1). For people who have serious health problems linked to weight, a doctor might suggest surgery or medicines to help with weight loss. With the rise of the obesity epidemic in the USA and the medical complications seen with it, weight loss and dieting have become a national concern. However, there has been a paucity of evidence for this dietary agent with multiple studies showing that weight loss was generally related to diet restriction as opposed to HCG injections 23, 25, 26. Part of getting diet pills is checking whether they interact well with other medications or supplements. While many weight loss supplements are safe to use, some — particularly those that contain caffeine — can have risky side effects involving blood pressure, heart rate, and heart function. Most over-the counter medications or supplements for weight loss are not recommended. While most people may lose weight on these medications, there are other factors at play. It may also interact with certain medications, so it is important to consult with a healthcare provider before taking green tea extract.PrimeShred converts even the most stubborn body fat into usable energy.As a team, you and your provider can create the right weight-loss plan for you.Some, but not all, insurance plans cover medications that treat overweight and obesity.Alli can reduce the absorption of fat-soluble nutrients, including beta carotene and vitamins A, D, E and K.A study of tirzepatide (LY ) once weekly in adolescent participants who have obesity or overweight with weight-related comorbidities.Because the medications contain different active ingredients, some people may tolerate one better than the other. Consider berberine an option for you to lose some weight and reduce your blood sugar levels. The medication metformin is currently the gold standard for helping people bring down high blood glucose levels. Find out more about healthy eating when trying to lose weight. But the weight loss amounts to only a few pounds, and the drug's side effects can be very unpleasant. Diets almost never work, and they can cause many people to fall into an unhealthy cycle of losing and gaining weight. Before you consider whether to use any over-the-counter diet aid, find out if you really need to lose weight. Working alongside a healthcare professional can reduce the risk of weight regain after coming off of Plenity and ensure you achieve the best results possible with the least side effects. Plenity can be a useful weight loss ally when combined with a reduced-calorie diet and exercise plan. However, the results of another meta-analysis of 10 studies found a significant decrease in FBG but not in insulin, and that the decrease in FBG was only significant for GCBE ≥400 mg/day . Two meta-analyses of randomized studies showed that GCBE or CGA between 200–2000 mg/day for 2–24 weeks significantly reduced FBG and insulin, and this was not influenced by dose level 78,79. Caffeine and CGA in GCBE can stimulate fatty acid oxidation and inhibit lipogenesis, which, in turn, decreases fat accumulation in the body . Of the studies included in four recent meta-analyses on GCBE and cardiometabolic outcomes 78,79,80,81, only seven assessed adverse events, and of these, two reported some undesirable side effects during the GCBE or CGA intervention. The guidelines for tirzepatide (Zepbound) and semaglutide (Wegovy) state that a patient should have a BMI of 30 or a BMI of 27 with weight-related health problems. Bupropion (Wellbutrin), an aminoketone, is considered weight-negative and is prescribed both to assist in weight loss and to treat depression. Desipramine, nortriptyline, and protriptyline have variable effects on weight. Weight-positive medications in the tricyclic antidepressant category include amitriptyline, doxepin, and imipramine. Meta-analyses of olderrandomized controlled trials (RCTs) of lifestyle modifications (i.e. diet andexercise) demonstrate that every 1 kg of weight loss corresponds to a short-term(2–3 year) decline in systolic blood pressure of 1 mm Hg 34, 35. Additionally, measurement of bloodpressure can be significantly complicated by large body habitus , further hindering the management of hypertension inobesity. Five drugs—orlistat, lorcaserin, liraglutide,phentermine/topiramate, and naltrexone/bupropion—are currentlyapproved for weight loss therapy in the United States. Weight loss medications in the treatment of obesity and hypertension. Always consult with a healthcare professional if you have any questions or concerns.Berberine can also help your body respond to insulin better, but not likely as well as metformin.For example, if you eat 2,000 calories a day, a high-protein diet would consist of 150 g of daily protein.You might be surprised to learn that makers of dietary supplements rarely do clinical trials.In turn, many of thecardiometabolic consequences of obesity have a reciprocal relationship withhypertension.You can lose the 50/50 to any one of these Standard Characters.Fiber aids gut health for sustained weight. For recommended treatments, please consult with your health care provider. Talk with your doctor before starting any over-the-counter product for weight loss. Many other over-the-counter products claim to help with weight loss. When cortisol is supported and recovery improves, the body often becomes more responsive to nutrition and movement again. But the body is not resisting change. Improving sleep quality often produces noticeable changes in energy, mood, and appetite regulation. The NAL/BUP combination was approved by the FDA in 2014 and by the Korea Ministry of Food and Drug Safety in 2016 (Jeon et al., 2023). Bupropion (BUP) is a dopamine and norepinephrine reuptake inhibitor known for its role in the management of depression and smoking cessation. In addition, the incidence of T2DM was 45% lower in the orlistat group than in the placebo group over 4 years (Torgerson et al., 2004). They are also at higher risk of developing weight-related conditions such as arthritis, low back pain, and obstructive sleep apnea than normal-weight individuals. When it comes to losing weight, a healthy diet and exercise plan is the holy grail. FDA approves treatment for chronic weight management in pediatric patients aged 12 years and older. Www.fda.gov/drugs/drug-safety-and-availability/fda-approves-weight-management-drug-patients-aged-12-and-older Researchers are currently studying several new medications and combinations of medications in animals and people. There have been clinical studies, but there aren’t enough of them to say with certainty how much weight people will lose when taking berberine. However, it’s been shown to help people lose some weight and lower their blood sugar levels. Association of vitamin B12 with obesity, overweight, insulin resistance and metabolic syndrome, and body fat composition; Primary care-based study. However, most people don’t pay list price if their health insurance covers their medications. Prescription GLP-1 and dual agonist medications usually produce much greater average weight loss than OTC products. Some people will benefit from short-term use and others will see the benefits of continuing berberine supplementation over time. That’s true of other supplements as well, which is why some practitioners recommend taking periodic breaks from supplements. Still, anyone considering taking berberine should first ask their health care provider. Side effects of berberine aren’t common, and the benefits of the supplement typically outweigh side effects. Take it before or in between meals, early in the day, rather than at night. Most people will regain some or all of the weight after they stop taking the medicines, unless they have made lasting lifestyle changes. But not everyone loses weight while taking them. Before trying weight-loss medicines, your health care provider will recommend that you try non-medicine ways for losing weight. Primeshred is a fat burner supplement that is designed specifically for men. One of the leading supplements is called TrimTone. Not only that, but women can also suffer from insecurity and lack of confidence when they have weight issues. PrimeShred has an overall rating of 3.6 out of 5 stars from 28 reviews but is still generally seen as one of the best weight loss pills. Natural weight loss supplements are designed to complement your existing fitness journey, but PhenQ takes it a step further. One of the best weight loss pills available is PhenQ, an over-the-counter supplement touted as potent in helping curb cravings, elevate energy levels, and attain a shredded look. No supplement or medication can miraculously eliminate body fat without someone needing to put in the necessary effort. I have tried to pick and rank top most popular weight loss supplements in the market. However, because of the cost of these medications, some insurance companies are introducing their own criteria for eligibility or requiring step therapy with the oral drugs. Women also need to be on reliable birth control if they're taking these medications. A study on Zepbound showed a more significant weight loss of 21%, “which is substantially more than you can expect to get from lifestyle alone,” Wolver said. Wegovy cost in the UK But they aren’t FDA approved for chronic weight management. However, Tricare no longer covers weight-loss medications for Tricare For Life beneficiaries. Coverage for Wegovy and other weight-loss medications varies by plan. Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist that was FDA approved in 2021 for chronic weight management. We’re all different, so we react to supplements and medications differently. Most of the weight loss pills work on thermogenic process, some do it effectively, while other just fulfill it in their claims. It is not easy to judge the best weight loss supplement as each of us have different body and therefore it is possible that one supplement that work for one, might not work for other. It totally depends on your body types, requirement, desired weight loss results, and most importantly, type of supplement are you willing to use. It acknowledges that being overweight can have serious effects on one’s general health and well-being and is not just a cosmetic issue. Choosing a medication to treat overweight or obesity is a decision between you and your health care professional. Weight loss of 5% to 10% of your starting body weight may help improve your health by lowering blood sugar, blood pressure, and triglyceride levels. Weight management medications don’t replace physical activity and healthy eating habits. Ask your health care professional about lifestyle treatment programs for weight management that will work for you. Interaction between specific fatty acids, GLP-1 and insulin secretion in humans. Yerba maté (Ilex paraguariensis) metabolic, satiety, and mood state effects at rest and during prolonged exercise. It’s possible that cinnamon helps blood sugar by increasing GLP-1 levels. No significant changes in lipid profile were reported in overweight adults after 12 weeks of capsaicinoid supplementation at 2 or 4 mg/day . Capsaicinoids may also affect food intake, and a meta-analysis of eight studies showed that capsaicinoid ingestion with a minimum dose of 2 mg before a meal significantly decreased ad libitum calorie (−74.0 kcal) during the meal, suggesting an appetite suppression effect . Early studies assessed the food and not capsaicinoid or capsinoid extracts but attributed putative effects to capsaicin. Walgreens.com has several weight loss DVDs available if you need ideas for your next workout. These help fight hunger pangs and allow you to fill your body with vitamins and nutrients rather than trans fats and high fructose corn syrup. Different body types require different types of pills, so research each supplement carefully before choosing the one that you feel is best for your needs. Patients starting AOMs should tell their doctor about any vitamins or supplements they are taking. They are not regulated by the FDA and do not have proper studies to confirm their safety and effectiveness. Other over-the-counter products are considered supplements. As with any supplement, it’s important to consult with a healthcare provider before starting any new regimen. Its blend of natural ingredients aims to reduce hunger cravings, boost energy, and support metabolism, making it a valuable addition to a healthy lifestyle. Powher Cut stands out as a comprehensive appetite suppressant tailored for active women. As with any supplement, it’s important to consult with a healthcare professional before starting any new regimen. Although initially a prescription medication, it is now readily available as an over-the-counter diet aid. However, isolated case reports started appearing that cited mania, panic attacks and psychosis as side effects of the medication . Dexfenfluramine, the d-isomer of fenfluramine, was also utilized in weight loss products because of its CNS selectivity. Toxic effects have been seen with doses of 15 mg/kg with fatalities seen in ingestions greater than 150 mg/kg . Adverse effects of the medication include headache, tremor, insomnia, agitation, chest pain with significant toxicity producing palpitations, and severe hypertension . Eighty percent of Americans take dietary supplements as part of a healthy lifestyle, including weight management products . Considering the low occurrence of undesirable side effects reported in clinical studies providing GCBE or CGA along with the low toxicity suggested by animal studies, it is unlikely that consumption of GCBE or CGA through weight management supplements is harmful. In summary, weight management supplements containing caffeine, GTE, GCBE, choline, glucomannan, and capsaicinoids and capsinoids are generally safe when taken as directed and demonstrate metabolic health benefits for overweight and obese people. As with any dietary component, the potential for gastrointestinal intolerance, as well as possible interactions with concomitant medications/supplements exist, and the health status of the consumer should be considered when consuming these components. Novo Nordisk shared in June 2025 that it’s moving both the injectable and pill forms of amycretin into phase 3 clinical trials for chronic weight management. This may lead to weight loss. After taking the medication once daily for 6 weeks, people in the study were able to perform better on an oral glucose tolerance test (OGTT). Wegovy is approved in the UK for individuals living with obesity to help them eat fewer calories and lose weight. Semaglutide is a GLP-1 receptor agonist that helps reduce hunger and appetite, allowing you to eat fewer calories, lose weight, and manage your blood sugar levels. Wegovy and Orlistat are weight-loss medications approved for use in the UK. While GLP-1 drugs are approved for type 2 diabetes, some are also approved for weight management and obstructive sleep apnea. Before starting any GLP-1 medication, consider scheduling a telehealth visit at Doctronic.ai to discuss your options and receive a tailored treatment plan. Advances in AI and telehealth platforms like Doctronic could support safer, more personalized medication management. They share similar potential side effects, including nausea, vomiting, and diarrhea. Neither medication is considered universally safer than the other. Some people may turn to online sources for GLP-1s like Wegovy and Zepbound. Weight loss results from Zepbound versus Wegovy in a month can depend on individual response, diet, and physical activity. Its release increases rapidly after the ingestion of nutrients including carbohydrates, fats, and proteins. The maximum dose of phentermine/topiramate ER is 15 mg of phentermine and 92 mg of topiramate; these doses are lower than those marketed or studied as monotherapies in obesity (Allison et al., 2012). Topiramate is a gamma-aminobutyric acid agonist, glutamate antagonist, and carbonic anhydrase inhibitor; it is a drug used for epilepsy treatment and migraine prophylaxis (Pilitsi et al., 2019). Support In this article, we offer comprehensive reviews of 9 of the best weight loss pills to help you lose weight and get in the best shape of your life. However, opting for weight loss pills–or even considering injectable options–can make the journey slightly less challenging while promoting healthier habits. There are lots of weight loss and fat burning supplements that claim to burn belly fat but as per me, MitoLyn is the best supplement to burn belly fat. Usually all natural weight loss pills and supplements work on same frame. Yes, most of the weight loss pills are actually healthy as they are formulated with natural ingredients. Its multi-faceted formula combines thermogenic compounds, appetite suppressants, and focus-enhancing ingredients to assist individuals in their weight management journey. Hydroxycut Hardcore Elite is a high-stimulant supplement that may support weight loss efforts through appetite suppression and increased energy expenditure. This mechanism positions Alli as a unique option among OTC weight loss pills. Together, they work synergistically to optimize your weight loss efforts 24/7. Designed with a unique combination of natural ingredients, this supplement doesn’t just help you eat less—it supports your mental game during weight loss too. Whether you’re trying to reduce snacking, curb late-night cravings, or lose belly fat, PhenQ delivers comprehensive support. PhenQ stands out as the best over-the-counter appetite suppressant and fat burner in 2026. Semaglutide is designed as an additional tool for weight management and, in most cases, shouldn’t be considered a lifelong medication. However, they are different medications with distinct dosing schedules, costs, and mechanisms of action on the body. However, Orlistat is a very different type of weight-loss medication, and research suggests it’s not as effective as Wegovy in supporting weight loss. You may see ads for supplements that claim to help you lose weight. And new data is raising concerns about the ratio of fat loss to lean mass loss, which has enormous implications for long-term metabolic health and maintenance. Both groups had the same medications, the same general diagnoses, and similar patient motivations and populations. Weight loss was sustained, strength was preserved, metabolic health improved, and patients continued progressing even after medication adjustments or discontinuation. Overweight and obesity have always been complex, multifactorial, behavior-linked, environment-sensitive, often identity-based, and—crucially—longitudinal. Weight loss pills are an excellent solution for those who want to lose weight but don’t want to go through the hassle of dieting or exercise. There are many weight loss pills on the market that can help you lose weight. Fat absorption is key to weight loss, which means using these pills can help burn fat. Diet pills are the most popular form of OTC weight loss pills because they have fewer side effects than other methods. They contain one or more ingredients shown in research studies to help lose weight by reducing appetite, managing hunger hormones, and boosting metabolism. Bupropion has been around for decades and was originally approved by the FDA in 1985 to treat depression.Additionally, the pill increases immunity, giving you more energy for everyday activities.Now, you can get that perfect body as you want and it brings in the confidence to go ahead in life.Zotrim is a time-tested, herbal-based appetite suppressant formulated to help users manage portion sizes, reduce unhealthy snacking, and feel fuller for longer.Despite this, over-the-counter supplements marketed as "appetite suppressants" have surged in popularity recently. I was all set to start using a diet aid, but my doctor talked me out of it. But we agreed on a plan where I will check in with her often so she can monitor my progress and any side effects I may have. I plan to use an over-the-counter diet aid. I know that I'm overweight because of some bad habits I've developed. I've tried to make healthy eating and exercise work, but I think I need more help. These can help you lose weight effectively because they’re natural ingredients proven to work over time. Diet pills are a great way to help manage your weight, but there are some important things to consider before you purchase one. We’ve done our best to gather all the information on the best OTC diet pills in one place so you can decide what works best for you. Both drugs are a great way to manage weight and improve body mass index (BMI). People who took bupropion reported greater energy and suppressed appetite, leading to the happy side effect of weight loss, which research confirmed. The best weight loss pills commonly provide a money-back guarantee in case you are not satisfied with their performance. Sometimes, the most expensive weight loss pills may not necessarily be the most effective. Reported acute adverse effects of the medication include fecal incontinence, flatus, oily discharge, oily evacuation, and soft stools.No matter which product you take, you should take orlistat with each of your main meals that contain fat.Phase 2 studies have used four different doses of orforglipron (12, 24, 36, and 45 mg); at week 26, the mean weight loss from baseline ranged from 8.6% to 12.6% across the orforglipron dose cohorts compared to 2.0% weight loss in the placebo group.He told me how the research just doesn't support using these products, especially considering some of the possible side effects.The absorption of fat-soluble minerals and vitamins such as E, A, D, and K is also partially inhibited, but patients in clinical trials did not suffer from vitamin deficiency if they consumed vitamin supplements concurrently with orlistat.A preclinical study reported that ecnoglutide reduced blood glucose and body weight and increased insulin secretion significantly more than semaglutide (Guo et al., 2023).The SURMOUNT trials found tirzepatide results in weight loss of 15% (5mg dose) to 20.9% (15mg dose) at 72 weeks, and 25.3% (10-15mg dose) at 88 weeks.15 It reduces energy intake by reducing appetite.16 Tirzepatide improves cardiometabolic measures including blood pressure, fasting insulin level, lipid levels and waist circumference.15 As with semaglutide, side effects include gastrointestinal symptoms such as nausea, diarrhea and constipation.15Several weight-loss medicines are available in the United States. Most of these products appear to include choline as a vitamin for nutrition purposes, but some claim that the added choline helps with fat metabolism and increases energy. Given that most women do not meet recommended intakes of choline during pregnancy and lactation, particularly women following a vegetarian or vegan dietary pattern, and that most prenatal vitamins do not contain choline, the DGA also states that supplementation may be necessary . For example, in the U.S., the average choline intake of men and women is 421 mg/day and 279 mg/day, respectively . Similarly, the EFSA set the recommended AI for choline at 400–550 mg/day for all adults and adolescents 14 years old and above, 375 for adolescents 9–13 years old, and 150–250 mg/day for infants and young children . The mechanisms driving altered medication handling in the settingof excess adipose tissue include expanded volume of distribution, alteredhepatic metabolism (due to nonalcoholic fatty liver disease) , renal hyperfiltration (or alternatively,impaired renal clearance due to chronic kidney disease) 18, 19, andincreased sympathetic activity 23, 24. Excess adipose tissuealso alters the pharmacokinetic and pharmacodynamic handling of manymedications. Adipose tissue possesses pathophysiologic properties that affectvascular behavior, sodium handling, and liver and kidney function, resulting inelevations in blood pressure and complicating the medical management of hypertension. Almost three-quarters of individuals with hypertension in the US areoverweight or obese ; correspondingly,higher rates of hypertension are observed in individuals with obesity compared tonormal-weight individuals . Much of the increased morbidity andmortality in individuals with obesity is due to adverse metabolic effects of adiposetissue. Insufficient data regarding long-term effectiveness and risks of side effects was available. This is a narrative review and, therefore, Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were not fully followed, and a quality assessment of selected studies was not performed. Another trial reported a similar proportion of participants discontinuing treatment due to adverse events (2.4% with semaglutide vs 2.3% with placebo) . However, due to its sympathomimetic effects, it should not be used in patients with uncontrolled hypertension. Losing weight can be challenging as various fad diets and exercise equipment often divert us from the right path. They reported minimal weight loss after three months of Body Recomp use and strongly prefer the previous formulation, suggesting a potential downgrade in effectiveness . These are, without a doubt, the cornerstones of any successful weight management journey. Taking more orlistat than recommended hasn’t shown any additional weight-loss benefits.Amgen plans phase III program for next-gen obesity drug targeting liver and kidney diseases.Certain fats are better for your heart and your waistline.Doctors prescribe weight loss medicines for people who are obese or overweight and have other health problems, such as high blood pressure or diabetes.Natural suppressants are ideal for women and men who prefer gentle, stimulant-free solutions or want to avoid side effects.Moreover, a meta-analysis of green tea or GTE supplementation of four clinical studies with subjects having non-alcoholic fatty liver (NAFLD) reported a decrease in BMI of −2.08 kg/m2 (95% CI, −2.81 to −1.36) .If you take Alli with a high-fat meal, you’ll likely experience more-severe digestive side effects.However, an earlier meta-analysis showed green tea/GTE remained effective in improving SBP and DBP in overweight and obese people but to a smaller extent . Let's explore some of the safest options backed by research to reach your weight goals. While no single solution is right for everyone, choosing an evidence-based treatment as part of a comprehensive wellness plan can set you up for sustainable success. However, we want you to understand all of your options - from tablets and injections to meal replacements and appetite suppressants. Nearly one in four people who come to our program has undiagnosed disordered eating.” Patients who turn to VCU Medical Weight Loss program are desperate for help and Wolver cares deeply about helping them.“That is what I am passionate about,” she said. There can be less than optimal oversight of this process and some people have been hospitalized. This blog was medically reviewed by registered dietitian Marie Barone. Maybe they'll even join you on your health journey. There are some foods that you love and may not want to give up when you're managing your weight. Some simply don't work, despite testimonials from people who may have been paid to participate. These include food intake, how much you exercise and your health status. Additionally, it is important to consult with a healthcare provider before taking any weight loss pills, as they may interact with certain medications or have negative side effects. These medications are designed to help people lose weight by suppressing appetite, increasing metabolism, or reducing fat absorption. Researchers are working to identify safer and more effective medications to help people who are overweight or have obesity lose weight and maintain a healthy weight for a long time. This would broaden access to these jabs considerably, as the health service currently restricts injections to those regarded as having the highest clinical need. Before he became editor of Discover in 2012, Steve George spent more than 20 years as a writer and editor, specializing in health and medicine. Our writers at Discovermagazine.com use peer-reviewed studies and high quality sources for our articles, and our editors review for scientific accuracy and editorial standards. As with many of the drugs listed here, gastrointestinal side effects may include indigestion, nausea, diarrhea or constipation, and other stomach complaints. Tirzepatide works similarly to semaglutide in that it also mimics a hormone in the body that regulates hunger, while additionally slowing down digestion and movement of food from stomach to small intestine. In addition, it's likely the weight will be regained when the medicines are stopped. Set up in 1967 by none other than the first health minister of India, Ms. Sushila Nayar, MGIMS is deeply rooted in Gandhian ethics.Read More Support your well-being and long-term goals through informed decision-making while maintaining professional guidance and a complete healthcare perspective. Do You Need to Take Wegovy Forever? Maybe, If You Want to Maintain Weight Loss Doctors prescribe weight loss medicines for people who are obese or overweight and have other health problems, such as high blood pressure or diabetes. In our review of authoritative reports and human clinical research, most of the ingredients appear to improve some aspects of metabolic health in people with overweight and obesity, such as supporting healthy blood glucose, lipids, and BP. Due to this complexity, weight management studies that assess dietary supplements in the context of other modalities can lead to challenges in discerning the effect of a specific dietary ingredient. We reviewed six ingredients that are representative of the broad range of dietary supplements used for weight management—caffeine, GTE, GCBE, choline, glucomannan, and capsaicinoids and capsainoids—for safety as well as evidence related to weight management and metabolic health. At week 36, the loss of body weight ranged from 9.4% to 14.7% compared to 2.3% reduction in the placebo group. Therefore, tirzepatide is likely to be particularly effective in improving obesity and its related complications; clinical trials of tirzepatide’s effects on obesity and obesity-related complications are ongoing. Mean weight loss from baseline with tirzepatide administration (10 mg or 15 mg) in SURMOUNT 1 to SURMOUNT 3 was 12.8% to 20.9%; this weight loss was significantly higher than in the placebo group (–3.1% to –2.5%) (Jastreboff et al., 2022; Garvey et al., 2023; Wadden et al., 2023). These placebo-controlled trials aimed to evaluate the efficacy and safety of tirzepatide, as an adjunct to lifestyle intervention, in chronic weight management in adults with a BMI ≥27 kg/m2 with or without T2DM. Semaglutide 2.4 mg reduced the physical limitations and improved exercise function compared with placebo (Kosiborod et al., 2023, 2024); semaglutide 1.0 mg delayed the progression of diabetic kidney disease, which is lower than that recommended for people with obesity (Perkovic et al., 2024). A Better Food Diary Experience It's always important to talk with your doctor about weight-loss goals and medical history to determine which treatment is right — and safe — for you. Not every weight-loss treatment is right for every person or every kind of weight-loss issue. Diet and exercise are still two of the most important ways to maintain a healthy weight, but certain meds may help. Most are available by prescription only and none are meant to replace a healthy diet and exercise plan. That only adds to the frustration of people struggling with their weight — of whom there are many. Work with your doctor to find the right treatment plan for your needs.Interaction between specific fatty acids, GLP-1 and insulin secretion in humans.He has a background in investigative and science journalism and has worked on documentary films about war and trauma, health, sanitation, and the changing climate around the world.It's important to remember that as you lose weight your body needs less food (calories), so after a few months, weight loss slows and levels off, even if you continue to follow a diet.Achieve your weight loss goals with personalized solutions at express weight loss clinic texas.Berberine with blood thinners needs caution.This designation is designed to speed up the review process for certain promising treatments.It usually starts to affect how you digest fat within 1 to 2 days.In addition, it delays gastric emptying and modulates central hunger–satiety controls, which, in turn, create a feeling of fullness, reduce food intake, and promote weight loss (Bailey, 2021). To compensate for reduced absorption of fat-soluble vitamins, it’s recommended to take a multivitamin at bedtime. If a meal is missed or contains no fat, skip that dose. Take one 60 mg capsule with each fat-containing meal, up to three times daily. It blocks the enzyme responsible for breaking down fats in the intestine, leading to approximately 25% of consumed fat being excreted undigested. “When I first came on the show, I knew people were going to comment on my weight, like they’d been commenting on my weight my whole life,” Gay told entertainment reporter Courtney Tezeno. Even if you use a telehealth service, a valid prescription is still required before you can receive the medication. Wegovy’s manufacturer offers a savings program for people who have commercial insurance that covers the medication. There are other prescription medications that contain semaglutide, the active ingredient in Wegovy. ACA marketplace plans aren’t required to offer obesity medication coverage, but some plans may. It's one of four similar weight-loss drugs approved for use for less than 12 weeks, called short-term use. Phentermine by itself (Adipex-P, Lomaira) also is used for weight loss. Other possible side effects include an increase in heart rate and blood pressure, insomnia, constipation, and nervousness. In rare cases, people have had serious liver injury with orlistat. You need to follow a low-fat diet when taking this medicine. No one can deny what GLP-1 medications have done for patients. And this isn’t just something I noticed about GLP-1’s or about weight loss in general. The American Psychological Association notes that chronic stress alters metabolic health independent of diet quality—meaning stalled progress is often physiological, not personal failure. This is a different approach from medications such as tirzepatide and VK2735. The study met all its main goals, with every dose of VK2735 leading to significantly more weight loss than placebo. It’s being studied for weight loss and Type 2 diabetes in adults. A new study is now seeing how it stacks up to semaglutide for weight loss. After about 68 weeks (15 months), adults without diabetes lost about 20% of their body weight on average. A greater effect was seen in Asian versus Caucasian populations, and also in those who have lower intakes of caffeine each day. A review in 2009 looking at all human studies conducted with green tea supported this claim. It is a stimulant and excessive consumption can cause short-term increases in blood pressure and heart rate. Try to avoid foods containing high levels of salt because they can raise your blood pressure, which can be dangerous for people who are already living with obesity. Your GP can advise you about losing weight safely by eating a healthy, balanced diet and doing regular physical activity. Participants who were receiving retatrutide continued to lose weight until treatment was stopped at 48 weeks, and the trajectory of the weight-reduction curves indicated that a plateau had not yet been reached. Orlistat (Alli): The FDA-Approved Option As mentioned above, orlistat is sold over the counter (OTC) as Alli and with a prescription as Xenical. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A.D.A.M. is among the first to achieve this important distinction for online health information and services. One of its side effects includes potential weight loss. Current GLP-1 agonists approved for weight loss include Wegovy, Zepbound and Saxenda. See what health experts have to say about Ozempic for weight loss However, Wegovy was made for weight loss while Ozempic is meant for people with type 2 diabetes. Also let them know what you’re willing to potentially spend on a weight-loss pill. The decision to start taking a weight-loss pill is a personal one. There are other considerations too, such as how often you need to take medication, and of course, cost. It’s hard to say which is the best weight-loss pill. The effects are less than the prescription dose. Based on this concept, Cegla et al. investigated the acute effects of intravenous infusion of a subanorectic dose of GLP-1 and glucagon on food intake. It is released in response to physiological challenges that threaten adequate blood glucose levels and drives glucose production to restore euglycemia (Sandoval and D’Alessio, 2015). The most common adverse events were gastrointestinal symptoms, including nausea, diarrhea, decreased appetite, and vomiting, primarily during dose escalation (Zhao et al., 2024). A phase 1 study reported that ecnoglutide was safe and generally well tolerated for up to 6 weeks; the most common adverse events were nausea, decreased appetite, and headaches, similar to other GLP-1 RAs (Guo et al., 2023). It is a modified GLP-1 (7-37) peptide containing an alanine-for-valine substitution at position 8, as well as a C18 fatty acid conjugation at the side chain of lysine at position 30. The FDA found no evidence to confirm that orlistat was the cause of the reported liver injuries. Xenical is approved for use in adults with a BMI of 30 or more (obese). Food and Drug Administration for use in adults 18 and older who have a body mass index (BMI) of 25 or more. Alli is a 60-milligram, over-the-counter version of orlistat (Xenical), a 120-milligram prescription drug. Researchers are studying many aspects of prescription medications to treat overweight or obesity, such a By choosing an off-label medication to treat overweight and obesity, your health care professional may prescribe Sometimes health care professionals use medications in a way that’s different from what the FDA has approved. Although phase 2 trials have used oral semaglutide at a dose of 40 mg, the Oral Semaglutide Treatment Effect in People with Obesity (OASIS) 1 trial used oral semaglutide at a dose of 50 mg once a day; this dose can cause greater reductions in body weight with a similar safety profile to 40 mg. Despite the high efficacy of GLP-1-based anti-obesity medications, the need for regular injections is still a significant barrier for many patients. Tirzepatide not only results in approximately 20% weight loss but also improves cardiovascular risk factors such as blood glucose levels, blood pressure, and blood lipid profiles, which could decrease metabolic syndrome and cardiovascular disease. In November 2023, tirzepatide became the first GLP-1/GIP dual RA approved by the FDA for chronic weight management. The STEP 6 (Kadowaki et al., 2022) and STEP 7 trials (Mu et al., 2024) were conducted in Asian populations and included people with T2DM; they demonstrated a mean weight loss of 13.2% and 12.1% in semaglutide and 2.1% and 3.6% in placebo, respectively. Monitor blood sugar if diabetic; alternatives may enhance meds. Berberine with blood thinners needs caution. Soaked, they gel for appetite curb. Orlistat (Alli) blocks fat absorption as the main OTC pill. It’s gentle for most with few side effects. Here I’ve evaluated some of the most commonly used products for weight loss for their effectiveness (but not necessarily safety). Dr Nicholas Fuller evaluates some of the most commonly used alternative weight loss medicines for their effectiveness. A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings. Novo flunks kidney disease trial, again linking obesity prospect to neuropsychiatric side effects. “I love seeing so many more people represented in color of skin and body type.” The desire to be thin may set some people who do not have obesity on a path to alternative ways and means of attaining weight loss drugs. For obesity and health problems related to weight, talk with your doctor about whether diet pills or surgery could help you. Diet pills and surgery can help with weight loss when combined with a healthy diet and physical activity. Phentermine-topiramate, sold under the brand name Qsymia, is an FDA-approved weight loss medication that combines phentermine, a appetite suppressant, and topiramate, an anti-seizure medication that also helps reduce appetite. They promise easy weight loss but there is no evidence that any of these products are of any value to assist weight loss, and some may be counterproductive or unsafe.26 Weight loss of 5% is sufficient to bring about improvements in some weight-related complications see Health benefits of weight loss. Bariatric surgery is the most efficacious long-term treatment for obesity and should be considered along with individual circumstances Other than the previously mentioned gastrointestinal side effects and loss of vitamins, there are concerns that orlistat may cause colon and breast cancer. And a comparison study found a similar occurrence of serious side effects in people using Zepbound and Wegovy. Which medication is more affordable can depend on your specific plan and health history. Yes, if you need more help managing your body weight, it’s possible to switch from Wegovy to Zepbound. Results showed greater weight loss with Zepbound compared with Wegovy (20% vs. 14%) at 72 weeks (16.5 months). Lean Belly 3x Review – Critical Research Found However, successful weight management, which includes not only weight loss but also weight loss maintenance (i.e., limiting weight regain), is challenging .In rare cases, injectable vitamin B12 can cause skin irritation or rosacea, but these aren’t common side effects.Next came a dual receptor agonist, Mounjaro, which is indicated for type 2 diabetes, and Zepbound, which is indicated for obesity.Yes, GLP-1 pills are considered good pills for weight loss when prescribed by professionals.The end-of-treatment heart rate increase was similar to or slightly higher than that observed with placebo (Ji et al., 2023).They don't reduce the amount of fat in your body. You can find the FDA's warning list, which includes many popular diet aids, at /ForConsumers/ConsumerUpdates/ucm103184.htm. The U.S. Food and Drug Administration (FDA) warns people not to use certain diet aids that are known to be tainted with drugs or chemicals. And there are very few such studies of diet aids. The more fat you eat, the worse the side effects are, so it's best to limit fat while you are taking this drug. The U.S. Food and Drug Administration (FDA) doesn't need to approve dietary supplements.Monlunabant’s side effect profile will continue to be evaluated in upcoming studies.Caffeine has been used as an approach in weight management because of its ability to stimulate both noradrenaline and dopamine secretions, which, in turn, may decrease BW and body fat (BF), as well as increase thermogenesis in brown adipose tissue via an unknown mechanism(s) .PhenGold is a natural weight loss supplement formulated to enhance the body’s natural fat-burning abilities.Many over-the-counter products for weight loss are available at drugstores, at supermarkets, and online.In short order, the medication gained a kind of rock-star status, growing in demand so rapidly that there has been a shortage of the drug.You should also do strength exercises and balance training 2 days a week.It also has many health benefits like its antioxidant content that supports immunity and thermogenic effects that lower the level of blood sugar. Momordica charantia extract seems to increase GLP-1 levels in both animals and people. One study in rats showed that ginseng compounds improved blood sugar and cholesterol levels and boosted GLP-1 release after 4 weeks of supplementation. These effects may be related to curcumin’s effect on GLP-1. Studies in animals show that curcumin can improve blood sugar control by increasing GLP-1 release. More studies on glucomannan in weight management are needed to confirm these findings and determine optimum clinical application conditions. A 2014 meta-analysis of eight human studies providing 1–3 g glucomannan/day reported a non-significant reduction of 0.5 kg , and a 2021 meta-analysis of eight studies reported a 1.27 kg weight reduction . Specific to dietary supplements, the ODS has stated, “Significant safety concerns reported for tablet forms, which might cause esophageal obstructions, but few safety concerns with up to 15.1 g/day of other forms for several weeks” . For example, a meta-analysis of randomized weight loss clinical trials in adults found GI-related symptoms in six of eight studies that assessed adverse events when konjac glucomannan was provided at 1.5–10 g for 3–12 weeks . A search of the Mintel GNPD indicated the recommended intake of glucomannan for weight management products containing glucomannan ranged from 10–3330 mg/day. I'm willing to have my doctor monitor my progress while I use a diet aid. I'm desperate and have to try something else, even though I know that diet aids don't usually work. Reasons not to use over-the-counter diet aids Reasons to use over-the-counter diet aids He said changing my lifestyle habits would be better for my health in the long run. Based on data reported in clinical studies, Wegovy is likely the most effective prescription weight-loss pill. These medications’ full benefits can take even longer to set in. Every weight-loss pill, or diet pill, operates on its own timeline. Up to 25% lost at least 10% of their body weight. Orlistat works by helping your body absorb less fat from the meals you eat. With its easy access and weight-loss promises, is Alli your answer for losing weight? Alli (pronounced AL-eye) is an over-the-counter drug meant for overweight adults struggling to shed excess pounds. Is Alli — an over-the-counter weight-loss pill — the solution to your weight-loss woes? At the one-year point, excess weight loss compared to placebo was 8.8 kg (95% CrI-10.20 to -7.42 kg), while it was 2.6 kg with orlistat compared to placebo (95% CrI -3.04 to -2.16 kg) . The combination of phentermine with topiramate has been approved by FDA for the management of obesity. It is an oral medication that most commonly causes gastrointestinal adverse effects, including steatorrhea due to impaired fat absorption, which may lead to a deficiency of fat-soluble vitamins and nutrients . If these lifestyle changes are not enough to help you lose weight or maintain your weight loss, your health care professional may prescribe medications as part of your weight-control program. These medications mimic a hormone in the body that helps regulate blood sugar and appetite, making them effective for improving metabolic health. These days, it seems like more people are taking GLP-1 (glucagon-like peptide-1) receptor agonist medications, like Wegovy and Ozempic, to lose weight. Yes, prescription GLP-1 medications like Wegovy are weight loss pills approved by FDA. While weight loss natural pills may support metabolism or energy, they cannot match the appetite-regulating power of GLP-1 medications. If you have type 2 diabetes, it may take you longer to lose weight using orlistat, so your target weight loss after 3 months may be slightly lower. Reducing the amount of calories in your diet will help you lose weight, but maintaining a healthy weight requires physical activity to burn energy. These diets can lead to rapid weight loss, but they are not a suitable or safe method for everyone, and they are not routinely recommended for managing obesity. With technical advances, novel therapeutic drugs are being developed to target different mechanisms underlying the pathogenesis of obesity; this could significantly impact the treatment of obesity and lead to more sustainable changes in weight and overall health. Topiramate was originally approved for use in the treatment of epilepsy, but one of its noted side effects was that the medication seemed to cause weight reduction by suppressing the appetite. Combine your weight management supplements with a healthy diet rich in low-fat dairy products, lean meat and fresh produce. Some weight management medications that curb appetite, such as phentermine, are approved by the FDA only for use for a few weeks. Remember, OTC weight loss medications that work pills can be helpful, but should be part of a healthy lifestyle. Typically, people can lose up to 3% to 17% of their body weight while taking one of these medications. For many people, Zepbound and Wegovy are effective medications for weight management. Wegovy (semaglutide) is a medication for chronic weight management designed to be used with a healthy diet and exercise. Individuals with obesity areat greater risk of treatment-resistant and treatment-refractory hypertension20, 21, and experience higher rates of end organ damage fromhypertension (i.e. cardiovascular disease and end stage renal disease) 4, 5,compared to normal-weight individuals. Taking into account the pathophysiologic drivers of elevated bloodpressure due to adipose tissue, individuals with obesity experience severalchallenges in the management of their hypertension (Table 1). Of these medicines, only liraglutide is approved by the FDA to treat weight-loss in people without diabetes. While weight-loss drugs can be helpful, the overall weight loss achieved is limited for most people. For lasting weight loss, using OTC weight loss meds with healthy habits is key. In summary, OTC weight loss pills can be effective, but they also come with risks. Side effects may lessen as your body becomes accustomed to the medication. If you’re taking OTC weight loss pills, watch for any unusual symptoms. GLP-1 medications can lead to GI side effects like nausea and bloating in about half of users. A tummy tuck she had before her weight loss. “The most shocking thing is that losing weight transformed my appearance more than any med spa treatment or surgery ever did,” she said. Along the way, Gay has also been candid about the money she spent trying to “fix” her appearance long before the weight loss. That changed when she incorporated GLP-1 medications into her wellness routine, something she initially doubted would work. “Everyone was like, ‘Lose weight before you go on the show.’ And I was thinking, ‘Honey, if I could lose weight, I would’ve done it 20 years ago.’” If you’re a woman looking for a holistic, sustainable way to manage hunger, stress, and sleep while supporting weight loss—Phen24 is a smart choice in 2026. Women appreciate Phen24 because it tackles not just the physical aspects of weight loss but also the emotional and hormonal factors often ignored by other products. Its non-stimulant nighttime formula is particularly useful for women dealing with stress-induced snacking or disrupted sleep patterns that hinder weight loss progress. However, if you have a higher budget and are looking for the most effective weight-loss injection in the UK, semaglutide is a better choice. So, if you’re looking for the most affordable weight-loss pill you can purchase over the counter, then Orlistat could be an option. Orlistat is an affordable medication that is generally well-tolerated. The over-the-counter version of Orlistat will cost around £18 a month, so it’s a very affordable medication. It’s a weekly weight-loss injection with semaglutide as the active ingredient. Zepbound is also being studied in certain people with heart failure, MASH, and chronic kidney disease. Wegovy has shown positive results for certain people with heart failure. Age can also affect which medication is prescribed. Because of this, your health history and risk factors can make one option a better fit over the other. Active antioxidants present in Sleep Lean capsules are supposed to promote heart health, increase vitality and energy, and support the body’s natural ability to maintain health. Nobody like seeing fat gather around your waist, which is where this powder drink comes into play. Before you buy the weight loss pill you can go through the customer reviews. As you consume less food it blocks the fat production and you can stay away from gaining weight. MitoLyn is a powerful weight loss supplement that helps you to stay slim. While prescription medications may offer stronger effects, natural and over-the-counter appetite suppressant pills are widely used and well-tolerated, especially for long-term, sustainable weight management. Individuals seeking appetite suppressant pills and effective weight loss supplements should consult healthcare professionals for current, safe, and approved options available over the counter. “These medications help people lose weight and help them keep it off.” The drugs have many positive effects, everything from a reduced appetite to benefits to the heart, kidneys and liver. Furthermore, approximately 8% ofpatients discontinued orlistat in clinical trials due to gastrointestinaladverse effects . Sinceantiobesity drugs are indicated as adjuncts to diet and exercise, typically anancillary lifestyle intervention is provided to all participants in RCTs assessingthe efficacy of these drugs. Of these, liraglutide, administered as daily subcutaneous injections, isapproved at the 1.8 mg dose for diabetes and 3.0 mg dose for obesity. Thecombination of sodium restriction and DASH diet is more effective than eithersodium restriction alone with regard to blood pressure lowering . However, there are much lower rates of sustainedweight loss due to lifestyle modifications than bariatric surgery . The following table lists different types of prescription and over-the-counter diet supplements.It also keeps you motivated and can alert you to plateaus or side effects.Choline and glucomannan represent supplements with expected lipotropic and satiety effects, respectively.Orlistat can also reduce the absorption of some fat-soluble vitamins, so it is important to take a multivitamin supplement while taking this medication.There are many over-the-counter diet products, including herbal remedies.Taking these drugs for a year can mean a loss of total body weight of 3% to 12% more than that lost with lifestyle changes alone.According to the Daily Mail, a multimillion-pound deal for a pilot scheme will be struck with a pharmaceutical firm, with a view to issuing prescriptions through chemists and health centres.Contact your insurance provider to find out if your plan covers these medications. Ikaria Lean Belly Juice, known as the “purple mojito,” is among the best weight reduction supplements available on the market. Ikaria Lean Belly Juice drink is a powdered weight loss product that tastes like “fizzy juice” and is full of fruits, veggies, and nutrients that are high in antioxidants. All sexes and ages enjoy this weight loss beverage. By avoiding unhealthy snacks that make you gain weight, you will also be able to reduce weight. Capsimax contains capsaicinoids, which are known to increase thermogenesis, a process that boosts the body’s metabolic rate and burns more calories. The product is marketed as a safe and effective way to achieve a leaner physique without the need for strenuous exercise or strict diets. As with any supplement, it is important to speak with a healthcare provider before starting. BHB salts are a synthetic version of this compound that can help the body achieve ketosis more quickly. BHB is a ketone body that is produced naturally by the body during ketosis. Side effects include headache, overstimulation, high blood pressure, insomnia, rapid or irregular heart rate, and tremor. Zepbound is approved to treat obesity in adults with a BMI of 30 or greater. It is intended to be used indefinitely, in combination with a healthy diet and exercise. This progression can help to alleviate side effects, which include gastrointestinal symptoms, headache, dizziness, and fatigue. All of the medications discussed here are contraindicated for pregnancy. The medication’s cost and side effects will also affect the decision. A study from FAIR Health published in May 2025 reports that more than 2% of U.S. adults took a GLP-1 for weight loss in 2024. The pharmacological treatment of obesity is a fast-changing landscape, and care providers must strive continuously to stay current. Supplements are rarely the answer to safe, sustained weight loss. Some weight-loss supplements have been found to have ingredients that aren't listed on the label, such as prescription medicines. A recently published meta analysis concluded that retatrutide led to the most weight loss among GLP-1-based treatments, but it also caused the most side effects. As with many other weight-loss medications, monulubant is linked to mild to moderate GI-related side effects. The decision came after early studies involving people who are considered obese showed significant and lasting weight loss.