The trained participants did, however, see greater effects from eating enough protein than the untrained participants did. This protein calculator is based on scientific training studies and meta-analyses investigating the effect of different protein intakes on body composition. Long-term strategies for weight management are essential. These include increasing dietary fiber and protein intake, drinking green tea, and incorporating certain spices like cayenne pepper into meals, which may help with appetite control and metabolism. Yes, several natural approaches can support weight management. Obesity Causes If you qualify, Noom Med will connect you with a licensed clinician who can help find the right medication for you and prescribe it, if needed. Monthly costs usually fall between $60 and $90, and digestive side effects are common, particularly when meals are higher in fat. If you haven’t lost at least 5% of your starting weight after a few months, continuing Alli® may not help you lose more weight. Never take two doses at once to make up for a missed one. For example, in trials, some lost 5-15 pounds in the initial weeks, setting the stage for more significant progress as doses increase. Yes, it is possible to lose weight on 2.5 mg of Zepbound, though the amount varies among individuals. Many users keep a journal of meals, moods, and weight changes. It may also help to read this guide every time you refill this prescription, to make sure you are taking it correctly. Because of the risk Qsymia poses to an unborn baby, the drug should only be dispensed by pharmacies that are trained in a special distribution program. The speed at which you lose weight will depend on your metabolism and your ability to stay active. Forty-five percent of participants said their health had improved. In one recent study, some patients stopped taking Qsymia and left the study. Many health insurance plans require enrollees to get prior authorization, and a few require enrollees to do step therapy. If not, contact your prescription plan provider and ask about your coverage options. Nearly all commercial plans not purchased through an Affordable Care Act (ACA) marketplace and about one-third of Medicaid and ACA plans cover this medication. Some health insurance plans cover Qsymia. The chart below contains GoodRx exclusive prices for 30-day supplies of different doses of Qsymia and its generic equivalent. The plethora of diets and weight loss strategies available can be overwhelming, making it difficult to discern what truly works. Losing weight and maintaining a healthy body mass index (BMI) is a challenge many individuals face, with the journey often being as unique as the person undertaking it. If you think you may have obesity, talk to a healthcare provider. Sticking with a long-term treatment plan can help you maintain weight loss. Since Qsymia is a prescription drug, it is vital for patients to consider the chemical ingredients that are included in this drug to help them understand whether the product could be effective and appropriate for them. Some patients lose up to 32 pounds by the 56th week of using this prescription drug, which equates to a drop of four to five inches from their waist3. Qsymia is a prescription drug that has been developed specifically to address common issues faced by obese people. Qsymia is approved for a broader age range than Zepbound Skip the missed dose and take your usual dose the next morning. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Ask your doctor if you have any questions about participating in the program or how to get your medication. This allows patients to achieve greater weight loss results. A majority of my patients lose the most weight on the “recommended dose” of 7.5 mg/46 mg and elect to remain at that dose. Many who had a large amount of weight to lose took the medication for 8 to 12 months with excellent results.Side effects were few and did not limit its use. Each physician has to take a training course so he is familiar with the drug and it’s side effects.I have treated several thousand patients with Qsymia since it’s approval 10 years ago. While there are no specific dietary restrictions with Qsymia®, it’s recommended to follow a balanced, calorie-reduced diet to maximize weight loss. It’s about making sustainable changes that not only lead to weight loss but also contribute to overall health and well-being. Understanding these interactions helps in preventing adverse effects and ensuring the optimal efficacy of all concurrent medications. The next sections will delve deeper into the integration of Qsymia® into a comprehensive weight management strategy, including lifestyle considerations and its interaction with other medications. Is phentermine a good choice for weight loss? Side effects can be an issue when taking orlistat. And Alli is only approved for adults. Keep in mind that Alli, the over-the-counter (OTC) version of orlistat, is a lower dosage than the prescription version. Prescription orlistat is approved for adults and adolescents ages 12 and older. The most common Contrave side effects are nausea, constipation, and headache. Hydration and regular movement, like walking 30 minutes daily, amplify the medication’s effects. Factors influencing success at 2.5 mg include baseline weight, diet quality, and exercise routine. When beginning Zepbound, the 2.5 mg dose serves as an introduction to the treatment. Starting at 2.5 mg helps patients acclimate without overwhelming side effects. Also, discontinuing the drug can result in a drop in energy and accompanying headaches and fatigue, since some people on Qsymia find that the medication significantly improves their energy. Qsymia will also interact with many medications, and can potentially cause life threatening medical issues if taken with certain medications like monoamine oxidase inhibitors. The way by which topiramate helps with weight loss is not exactly known. Together, both drugs work synergistically to aid in weight loss. Wegovy (semaglutide) often remains on formularies for eligible patients, with similar prior authorization requirements. Manufacturer savings programs from Eli Lilly, such as the Zepbound Savings Card, may reduce out-of-pocket expenses for eligible patients paying commercially. Without insurance coverage, Zepbound can cost around $1,000 to $1,500 per month, depending on the dose and pharmacy. When coverage is possible, Aetna often requires prior authorization to confirm medical necessity. Self-funded employer plans may have more flexibility to include Zepbound if the employer opts for broader weight management benefits. Study 1 adjusted for baseline body weight and diabetic status.‡Statistically significant versus placebo based on the pre-specified method for controlling Type I error across multiple doses. Transformyou will help you stay on track with your medical weight loss goals, checking in on you frequently regarding your general health, weight, etc., and adjusting your medical weight loss plan according to your needs. Qsymia is an FDA-approved prescription medicine designed to assist adults who are seeking to lose weight or have weight-related medical problems. The inclusion of topiramate is particularly significant as it aids in reducing hunger and promoting weight loss, working synergistically with phentermine. Qsymia contains two medications, phentermine and topiramate, which work together to reduce your appetite and help you feel full. Food and Drug Administration has removed the requirement for a cardiovascular outcome trial for its weight-management medication QSYMIA (phentermine and topiramate extended release capsules) CIV. Qsymia is an effective prescription medication for weight loss. Your ideal weight loss medication depends on your health history, budget, and goals. The safety and effectiveness of QSIVA in combination with other products intended for weight loss, including prescription and over-the-counter drugs and herbal preparations, have not been established. QSIVA is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of 30 kg/m2 or greater (obese) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related medical condition such as high blood pressure, type 2 diabetes, or high cholesterol. Your prescriber will ask you to take a pregnancy test before starting the medication. Because of this risk, the FDA put a special program called a Risk Evaluation and Mitigation Strategy (REMS) in place for the medication. Studies show that taking topiramate, an ingredient in Qsymia, early in pregnancy can raise the risk of birth defects like cleft lip. So, you can't take this medication if you're pregnant. Qsymia is prescribed as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults. Together, these ingredients help reduce food intake and promote weight loss through their combined actions. Qsymia consists of phentermine and topiramate in an extended-release capsule. Qsymia combines two active ingredients to help manage weight in individuals facing obesity or related conditions. It’s FDA-approved for adults and works best when paired with healthy habits like balanced eating, regular movement, quality sleep, and stress management. The right timing, food choices, and adjustments can help reduce side effects and improve the medication’s effectiveness. The two ingredients, phentermine and topiramate, each target different systems, and those changes can lead to some reactions. Calibrate is a weight loss company that focuses on the body’s biology to provide a reset that can boost weight loss. Part of your weight loss plan may include the use of medication to boost your metabolism and help you see results faster. Even with a low dose, Qsymia has provided a boost in weight loss when working out and eating right. It depends on what health conditions you have. Lower-cost single-dose vials are available through LillyDirect for $349 (2.5 mg) and $499 (5 mg, 7.5 mg, and 10 mg) per month. This can help ensure that your medication is available when you need it. It’s a good idea to call your pharmacy at least 1 week ahead of when you’ll need to refill your Zepbound prescription. Xenical can cause some uncomfortable side effects. What should I know about storage and disposal of this medication? This improves overall health and lowers the risk of developing complications related to obesity. Our caring team of Mayo Clinic experts can help you with your obesity-related health concerns. Always check with your healthcare provider. "I am happy to report that I lost 12 pounds over the duration of the program…the wealth of information provided and the wholistic approach which included nutrition exercise and motivation, have better equipped me to make generally healthier lifestyle choices…" The real goal isn’t just to weigh less.The goal is to remain capable, strong, and confident inside your body. Health isn’t something you outsource to a syringe—it’s something you signal to your body every day through movement, nutrition, sleep, and consistency. Of all the interactions as you are NOT to ingest grapefruit when taking this drug as it doesn't allow it to clear out of your system. I lost most of my weight in the first couple months. My side effects were excessive phlegm, anxiety, mental confusion, rapid heartrate. Great results but don't like the side effects and have decided to go off after 5 months. In a phase 2 dosage trial, an oral version of VK2735 helped adults considered obese lose up to about 12% of their body weight in 13 weeks (3 months). By comparison, nearly 20% of people receiving a placebo saw similar results. In June 2025, Innovent Biologics announced that China’s regulatory agency approved mazdutide for chronic weight management in adults considered overweight or obese. It’s being studied for weight loss and Type 2 diabetes in adults. A new study is now seeing how it stacks up to semaglutide for weight loss. PHEN/TPM is not recommended for patients with recent or unstable cardiac or cerebrovascular disease; it is also contraindicated in patients with glaucoma and hyperthyroidism. The three-quarter-dose is mainly intended to facilitate gradual escalation from the mid- to full-dose. In order to minimize adverse effects, physicians should start with the lowest dosage and slowly titrate as recommended. Eye problems in people with Type 2 diabetes (diabetic retinopathy) Even before you are aware of your pregnancy, side effects may have already begun. There is a wide range of side effects that follow the use of Qsymia. Make sure you are following your doctor’s advice so that you do not face any side effects of withdrawal. Weight loss of ≥5% was achieved by 21% of subjects assigned to placebo compared with 62% and 70% of subjects assigned to mid-dose PHEN/TPM and full-dose PHEN/TPM, respectively. The study demonstrated that there was no evidence that PHEN/TPM could have fewer adverse effects than either drug alone. Subsequently, PHEN/TPM was evaluated in three Phase III trials for its long-term efficacy and safety; ancillary diet and lifestyle counseling were provided for patients in all trials. And get medical help right away if you have trouble breathing, swelling of the face or lips, blisters on the skin, or fever. This can make it harder to control your body temperature. The risk might be higher if you're on a ketogenic (keto) diet. Diala Alatassi, MD, is a board-certified obesity medicine specialist who is committed to providing comprehensive, compassionate, and personalized care. Research has not assessed its effectiveness in people with a lower BMI or those under 18 years of age. GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. The data reflects health insurance coverage as of May 2025. Keep in mind that since Qsymia is a controlled substance, your state may not allow the use of discount cards on your prescription. But it’s combined with phentermine in an FDA-approved weight loss medication called Qsymia. Topamax (topiramate) is an anti-epileptic medication that causes weight loss in some people. If you’re interested in taking medication to help you manage your body weight, talk to a healthcare professional. Weight loss is a common side effect reported by people taking Topamax for these conditions. It’s FDA approved to treat seizure disorders and prevent migraines. Topamax is an anti-epileptic medication. An overview of the potential fetal risks of Qsymia and information about recommended pregnancy testing and effective birth control for patients who are able to become pregnant while taking Qsymia. It's one of four similar weight-loss drugs approved for use for less than 12 weeks, called short-term use. Most prescription weight-loss drugs work by making you feel less hungry or fuller. Six weight-loss drugs have been approved by the U.S. Many people gain back some of the weight they lost when they stop taking weight-loss drugs. Taking these drugs for a year can mean a loss of total body weight of 3% to 12% more than that lost with lifestyle changes alone. This medication is only intended for patients who have been clinically diagnosed as overweight or obese. Clinical trials conducted on patients who took Qsymia and also changed their diet and exercised more showed an average weight loss of 6.7% and 8.9% per person. If adult patients haven’t lost at least 5% of baseline body weight or pediatric patients ages haven’t experienced a 5% reduction in baseline BMI, discontinue treatment. Back pain and blurred vision were relatively common (affecting more than 5% of patients) with high-dose treatment (15/92 mg). It is possible that patients who had experienced more ADEs did not continue to the SEQUEL extension; therefore, the assessment or reporting of ADEs would appear lower.10,11 Other relatively common ADEs (affecting more than 5% of patients) in the low-dose treatment groups (7.5/46 mg) were dysgeusia and dizziness. Significantly more treated patients lost 5%, 10%, 15%, and 20% or more weight compared with those receiving placebo. A randomized, double-blind, placebo-controlled, 52-week extension of the CONQUER trial was conducted to determine the long-term efficacy and safety of phentermine/topiramate CR (see Table 2, page 449). Patients on Qsymia® have experienced significant weight loss compared to those on placebo, with sustained results over extended periods when combined with diet and exercise. These references are essential for healthcare professionals, researchers, and patients who seek a deeper understanding of the medication’s scientific background. Understanding these aspects is crucial for patients and healthcare providers to ensure a safe and effective weight management strategy. Some people who take the drug without implementing a healthy diet still lose a minimum of five percent of their body weight. Studies have found that (phentermine / topiramate ER (Qsymia) causes weight loss when it is combined with a healthy diet and regular exercise. Qsymia is a prescription medication that combines phentermine and topiramate to aid in weight loss. 56 weeks of treatment Review the study design and clinical data for the CONQUER clinical trial. Transformyou serves patients from our practice in Phoenix, Arizona and also offers telemedicine appointments. All patients always work directly with one of our licensed physicians to ensure patient safety and confidentiality. Others are approved for treatment of diabetes with weight loss as an added benefit. The goal of obesity treatment is to reach and stay at a healthy weight. The amount of time it takes to see results from a weight loss diet and exercise plan can vary depending on individual factors such as starting weight, body composition, and activity level. By incorporating enough fiber into the diet, individuals can support their weight loss efforts, promote overall health and well-being, and reduce the risk of chronic diseases such as heart disease, type 2 diabetes, and certain types of cancer. If you have type 2 diabetes, weight loss may increase the risk of low blood sugar. Regular monitoring of the heart rate is recommended for all patients taking Qsymia, especially when starting or increasing the dose. It can aid in weight loss by increasing the feeling of being full, making foods taste less appealing and increasing the burning of calories. However, clinical studies have shown that individuals using Qsymia can start to see noticeable weight loss within the first few weeks of treatment. By combining phentermine and topiramate, Qsymia targets weight loss through multiple pathways. Your healthcare team can help you choose a phentermine alternative based on your other health conditions, medication list, and insurance coverage. But if you’re unable to take phentermine or it doesn’t work for you, there are alternative weight-loss medications available. It also suppresses the appetite and is a strong anorexiant drug. But there are some theories; scientists believe that it might work by enhancing the utilization of energy in your body and decreasing your appetite. This usually comes in the form of an extended-release capsule (a capsule designed to release the medication at a pre-determined time). However, results are highly dependent on the extent to which benefits are maintained post medication cessation. LeafyBark isn’t just a source of information; it’s a community where health-conscious individuals connect and thrive. And in May 2025, the first generic version of Qsymia (phentermine / topiramate ER) was released. It is approved for chronic use for appropriate individuals including teens down to age 12 with obesity. This gives very good appetite control – the phentermine through the first half of the day, then the topiramate during the second half of the day. How you prefer to take medication may guide your decision between the two. I LOVE the recipes that the Mayo Clinic Diet provides—very filling, flavorful, and truly healthy,” Brown says. Also had felt jittery and shaky but chalked it up to my body adapting and something to ‘work through.'” Even before vision issues, Brown experienced a few additional “minor” side effects. “Within a couple of days of no longer taking the medication, my vision returned to normal. Remember, managing your health is a team effort, so be sure to discuss your options with your prescriber too. Attempting to resist the constant daily cycle of hunger cravings when trying to lose weight can be extremely frustrating because willpower alone is often just not enough. Saxenda may also have undesirable effects on breastfed babies, so nursing is not recommended. Trial data revealed that the cost of the Qsymia recommended dose is $1,498 per participant for 1 year. Largely due to improvements in PCS scores, both groups saw statistically significant improvements in QoL at 56 weeks, 0.009 and 0.027, respectively, resulting in an adjusted improvement of 0.021 for those on Qsymia recommended dose (p 2). At baseline, using the Brazier and Roberts algorithm, the imputed QoL scores were 0.797 and 0.803 for the placebo and Qsymia arms, respectively. Over the 56 weeks, both groups saw improvements in PCS scores, yet the adjusted change in PCS was 2.28 points higher for the Qsymia recommended group compared to the placebo group (p 2). Zepbound may result in greater weight loss and has proven benefits for obstructive sleep apnea. And a comparison study found a similar occurrence of serious side effects in people using Zepbound and Wegovy. Which medication is more affordable can depend on your specific plan and health history. This gives your body time to adjust to Zepbound and find the right dose for you. Yes, if you need more help managing your body weight, it’s possible to switch from Wegovy to Zepbound. Wegovy belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists. Clinical data suggests 5-10% body weight reduction over time, but initial results are gradual. Ultimately, success depends on individual commitment and medical guidance for long-term health improvements. Sustaining weight loss requires ongoing commitment. This not only aids weight loss but improves mood and overall well-being. Phentermine is approved for use for up to 12 weeks. Phentermine (Adipex-P, Lomaira) is a prescription medicine used to lessen appetite. The program will also help you build habits that support long-term health, with the tools and support to make those changes last. As these anti-obesity drugs are approved for long-term management, they provide a better appreciation of the complex, chronic, and relapsing nature of obesity . During the last few decades, some anti-obesity drugs were used to treat morbid obesity; however, many of them were removed from the market owing to long-term side effects, particularly cardiovascular issues . However, as the rate of long-term adherence to lifestyle modifications is low, most patients with obesity lose only modest weight with non-pharmacological interventions alone . Therefore, efforts to control weight and minimize regain during the COVID-19 crisis should be emphasized in patients with obesity. Serious skin reactions (Stevens-Johnson Syndrome SJS and Toxic Epidermal Necrolysis TEN) have been reported in patients receiving topiramate. For clinically significant or persistent symptoms consider dose reduction or withdrawal of Qsymia. Symptoms typically occur within 1 month of initiating treatment with topiramate but may occur at any time during therapy. Acute angle closure glaucoma has been reported in patients treated with topiramate, a component of Qsymia. Traditional GLP-1 medications were effective, but resulted in less weight loss overall. A recently published meta analysis concluded that retatrutide led to the most weight loss among GLP-1-based treatments, but it also caused the most side effects. As with many other weight-loss medications, monulubant is linked to mild to moderate GI-related side effects. At the highest dose, people lost about 11% of their body weight on average over 72 weeks (nearly 17 months). Phentermine (Adipex-P, Lomaira) is a prescription medicine used to lessen appetite.Obesity is a disease where an abnormal or excess accumulation of fat causes harm to one’s health.You need to follow a low-fat diet when taking this medicine.Another difference between Zepbound and Qsymia is their approved age ranges.Information provided on this website is for informational purposes only and is not intended as a substitute for advice from a physician or other health care professional, or for information contained in any product label, packaging or insert.In many clinical trials that assessed pharmacologic interventions for more than 12 months, a weight loss of 4 to 8% was typical , which is rather disappointing considering the high prices of these drugs.Then went up to the 7.5 dose and after two weeks on that dose my hair started falling out.By activating the GLP-1 receptor, Mounjaro increases feelings of fullness, reduces hunger, and slows gastric emptying, leading to significant weight loss. They can review your personal medical history and help you weigh the risks and benefits of each option. It also has a boxed warning (the FDA’s most serious medication warning) for the risk of thyroid C-cell tumors. Other side effects include headache, gas, and fatigue. Common Wegovy side effects are mainly stomach-related, such as nausea, vomiting, and diarrhea or constipation. A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings. Innovent's Mazdutide shows superiority in glycemic control with weight loss over semaglutide in a head-to-head phase 3 clinical trial DREAMS-3. Lilly's selective amylin agonist, eloralintide, demonstrated meaningful weight loss and favorable tolerability in a Phase 2 study of adults with obesity or overweight. Amgen wants in on the booming weight loss drug market — and it’s taking a different approach. Research study to investigate how well semaglutide tablets taken once daily work in people who are overweight or living with obesity (OASIS 1) (OASIS 1). The two medications — phentermine and topiramate — work together to reduce your appetite. In general, people typically lose less weight with oral weight-loss medications than injections, such as Zepbound. Zepbound (tirzepatide) is one of several FDA-approved weight-loss medications. Achieving and maintaining healthy weight goals can play a crucial role in mitigating this risk.Dysgeusia, insomnia, and dizziness occurred in more than 10% of patients who received the 15/92-mg dose.6,7,10,11Clinically-proven weight-management results in adults and children ages when combined with a healthy diet and regular exercise.1,2We have a nationwide network of licensed providers who can prescribe GLP-1 medications.After about 68 weeks (15 months), adults without diabetes lost about 20% of their body weight on average.Alcohol is just empty calories that can lead to overeating and snacking on unhealthy foods.Although base-case results suggest that Qsymia is cost-effective, this result hinges on the time on Qsymia and the extent to which benefits are maintained post medication cessation. Average results at 56 weeks with patients taking Qsymia 15/92 mg. Weight loss by obesity class Patients who achieved 15%, 20% and 25% weight-loss results. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. If you are a Mayo Clinic patient, we will only use your protected health information as outlined in our Notice of Privacy Practices. Do not share phentermine with other people, even if they have the same condition as you. If you become pregnant, contact your healthcare provider right away. Tell your healthcare provider right away if you have any of the following symptoms, or if you have been told by others you have these symptoms. Misusing phentermine can lead to serious side effects like hallucinations or psychotic-like behaviors. Call your healthcare provider right away if you have any of the following symptoms of heart valve disease. It takes about 4 weeks to notice weight loss from Contrave. And around 20% of adults lost at least 10% of their body weight. In studies, about 40% of adults lost at least 5% of their body weight after taking Contrave for 1 year. One of the predominant agonists of the 5-HT2b receptor is fenfluramine that is believed to cause adverse CVD effects by stimulating mitotic activity, resulting in cell overgrowth within the valve leaflets . The side effects of non-specific serotonin agonists, such as fenfluramine and dexfenfluramine, are caused due to the stimulation of the peripheral 5-hydroxytryptamine 2B (5-HT2b) receptors. Some serotonin agonists exert anorectic effects (increase satiety that results in reduced food intake) by stimulating the proopiomelanocortin (POMC) receptors in the arcuate nucleus of the hypothalamus . In recent years, the US Food and Drug Administration (FDA) has approved newer pharmacological options that were developed more cautiously and elucidated safety as well as efficacy . They may want to lower your dose to help manage them. You’ll start with a low dose of Qsymia and gradually increase it to the desired dosage. People continued to lose weight after taking Qsymia for more than 2 years. As mentioned, Qsymia is approved for long-term use. As of January 2026, 12 medications are FDA approved as weight-loss treatments. While there are multiple weight-loss medications already on the market, there are also several new weight-loss drugs in clinical trials. All of these weight loss medications work better than a placebo, but none is ideal. By co-prescribing a fiber-containing supplement, such as psyllium, the gastrointestinal side effects of orlistat can be reduced.A tablet version of the medication is also in the works, but it’s in earlier stages of development.Therefore, if a patient fails one medication, then it is very reasonable to try a medication with a different MOA.A behavior modification program can help you make lifestyle changes to lose weight and keep it off.Head-to-head comparisons of medication uses, side effects, warnings, and more.Contrave (naltrexone / bupropion) is also a combination medication that’s approved for weight loss.Boehringer’s obesity candidate survodutide shows strong potential in MASH. An ongoing phase 3 trial will help confirm how effective retatrutide is for weight loss. And that’s why it seems to provide significant weight loss. How does retatrutide work for weight loss? Are weight-loss medications effective for the long-term treatment of obesity? About QSYMIA QSYMIA is indicated in combination with a reduced-calorie diet and increased physical activity to reduce excess body weight and maintain weight reduction long term in adults and pediatric patients aged 12 years and older with obesity, and in adults with overweight in the presence of at least one weight-related comorbid condition. CAMPBELL, Calif., March 04, (GLOBE NEWSWIRE) -- VIVUS, LLC., a biopharmaceutical company committed to the development and commercialization of innovative therapies that focus on advancing treatments for patients with serious unmet medical needs, today announced a global initiative, VIVUS For Life, to promote sustainable and healthy weight management. New diet drug is now available with a prescription for obese or at-risk overweight patients Data from meta-analyses of the anti-obesity drugs approved for long-term use for weight loss All patients had a 75-g oral glucose tolerance test and were required to have normal glucose tolerance or impaired glucose tolerance, but not T2DM. Most of these AEs were greatly reduced after taking the drug for 2 years. The inhibition of these enzymes causes dietary fat to remain undigested as triglycerides, which cannot be converted to absorbable free fatty acids and monoglycerides, leading to decreased calorie absorption. This involves providing evidence from healthcare providers. In 2026, weight loss use may require additional documentation. This partnership ensures members access medications at affordable rates. Central to our weight loss program is a range of high protein meal plans guaranteed to suit your taste and needs. Discover how our program delivers real weight loss results for our members. Learn how much weight you could lose & get a clear path to success with our easy weight loss predictor. In such cases, it is recommended that they try a suitable weight loss medication. Weight loss medications tend to have limitations, especially because they force the body to revert to its previous form once stopped. It is also crucial to consult your physician before considering weight loss medication, as only they can help definitively determine if one is suitable for you. A balanced diet and physician-advised physical activity are essential alongside these weight loss pills. In this case, weight loss pills and medicines can be useful for a select group of people. Skip the missed dose and resume your normal schedule the next morning. If you accidentally skip your dose of Qsymia®. Since it is an extended-release medication, it’s specially designed to release its ingredients slowly throughout the day. Of note, the patients receiving intermittent therapy experienced some weight regain or lost weight more slowly during the 4 weeks on placebo. None of these patients exhibited cravings for phentermine or typical withdrawal symptoms that would be expected in a patient abruptly stopping therapy with an amphetamine related medication. The potential for abuse with phentermine is a major concern among providers which may preclude prescribing this agent for weight loss. Other contraindications for phentermine therapy include use with monoamine oxidase inhibitors, hyperthyroidism, glaucoma, agitation states, pregnancy, and use in patients with known history of drug abuse.55 Some plans may restrict GLP-1 drugs to type 2 diabetes patients unless weight benefits are included. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. And it may help you burn calories while your body is at rest. To take the drug, you'll need to have test results that show you have one of these conditions. There are no known interactions between phentermine and foods or drinks. It is not known if phentermine passes into breast milk. Weight loss is not recommended during pregnancy, even if you are overweight. This will help them determine if phentermine is right for you. A reduction of insulin dose or oral hypoglycemic dose may be necessary in some people with diabetes. The MOA of this drug class itself is enough to urge caution to prescribers.11 Special attention should be given to patients with diabetes when using sympathomimetics. The adverse effects (AEs) for this drug class are to be expected from an increase in the release of biogenic amines in the central nervous system (CNS). As a result, these drugs should be used with caution in patients with renal impairment; however, there are no specific contraindications listed for patients with poor renal function. Further, there was no significant difference in daily medication costs between the placebo group and Qsymia recommended dose at trial cessation. These results suggest that the Qsymia recommended dose plus diet and exercise may be cost-effective, depending on the time on Qsymia medication and whether QoL benefits persist 2 years beyond medication cessation. This paper presented the incremental cost-effectiveness (cost per quality-adjusted life year gained) of the recommended dose of Qsymia plus diet and exercise relative to diet and exercise alone (plus placebo). Participants reported daily prescription medication use (dosage and name of drug) at baseline and study conclusion. Mochi Health connects Virginians everywhere with specialized weight management care through our convenient telehealth platform. A licensed pharmacy will ship any prescribed medications right to your door. Our online weight loss clinic in Virginia makes connecting with specialized care straightforward and stress-free. Most weight loss occurs in the first six months of taking Alli®.Users typically start with a low dose and gradually increase it to minimize side effects like nausea or fatigue.As with other oral options, you may lose less weight with Qsymia than with Zepbound.And Alli is only approved for adults.About VIVUS VIVUS is a biopharmaceutical company committed to the development and commercialization of innovative therapies that focus on advancing treatments for patients with serious unmet medical needs.Wait at least 30 minutes before eating, drinking anything else, or taking other medications.A total of 1,267 patients were enrolled in 91 sites in the U.S. consisting of clinical practice sites, clinical trial sites, and academic centers. Some side effects of Qsymia get better as your body gets used to the medication and usually go away on their own. An HSA allows you to use tax-free dollars to pay for eligible prescription medications. These programs are state-run and help qualifying residents pay for prescription medications. These programs help eligible residents get prescription medications at reduced costs. If you wish to receive one of these medications, speak to your local healthcare provider. Data from clinical trials on FDA-approved medications should NOT be used to make assessments related to compounded medications. If you decide to stop taking Qsymia®, your healthcare provider will likely recommend gradually tapering off the medication to minimize potential withdrawal effects. It’s crucial to inform your healthcare provider about all medications and supplements you are taking to avoid adverse interactions. In addition, more patients on PHEN/TPM had dose reductions (14% with full-dose PHEN/TPM, 10% with mid-dose PHEN/TPM) than with placebo (3%). In 1-year Phase III trials, twice as many patients discontinued due to an adverse event with full-dose PHEN/TPM compared with placebo (17.5% versus 8.5%); mid-dose PHEN/TPM had fewer (11.5%) adverse-event related discontinuations compared with the high-dose. Mean weight changes were −1.6% with placebo, −5.1% with low-dose PHEN/TPM, and −10.9% with full-dose PHEN/TPM. OB-302 was a 56-week trial that randomized 1267 morbidly obese patients with a BMI ≥ 35 kg/m2 (no BMI upper limit) without significant comorbidities to low-dose PHEN/TPM (3.7/23 mg), full-dose PHEN/TPM (15/92 mg), or placebo.50 At baseline, the mean BMI for the entire study cohort was 42 kg/m2. The COR-Diabetes Trial was a 56-week randomized, double blind, placebo-controlled study. Patients were instructed on a hypocaloric diet that was a 500 kcal per day deficit based on World Health Organization algorithm for calculating metabolic rate and they were urged to increase physical activity. The COR-1 study was a 56-week randomized, double-blind, placebo-controlled study. In week 3, patients took 2 tablets in the morning and 1 tablet in the evening. The COR-Diabetes trial included the same study design but focused on patients with DM. Washington and Colorado follow similar guidelines, emphasizing prior trials of other drugs. Track side effects and report to your doctor for ongoing coverage. Once approved, use a Kaiser pharmacy for the lowest cost. This combination works synergistically to cause weight loss at lower doses compared with the individual products used alone, thereby reducing adverse effects. The capsules combine a previously FDA-approved weight-loss medication with an approved antiepileptic agent known for weight loss as a side effect. Throughout the 52-week extension, treated patients showed a significantly greater percentage of weight loss compared with placebo patients. Another adjunctive agent, lorcaserin (Belviq, ADP-356, Arena/Eisai), approved in June 2012, brought about a weight loss of 4.5 to 5.8 kg during clinical trials.5 (Lorcaserin’s launch was delayed until June 2013 in order to resolve its classification as a Schedule IV substance.) Zepbound is an injectable prescription medication approved by the FDA for chronic weight management in adults. Moradi S, Kerman SR, Mollabashi M. The effect of topiramate on weight loss in patients with type 2 diabetes.A reduction in the dose of antidiabetic medications, which are nonglucose dependent, should be considered to reduce the risk of hypoglycemia.Mounjaro is indicated for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise- as monotherapy when metformin is considered inappropriate due to intolerance or contraindications- in addition to other medicinal products for the treatment of diabetes.Off-label drugs for weight management.Phentermine is a stimulant that suppresses appetite, while topiramate is an anti-seizure medication that can also cause weight loss as a side effect.Remember that taking extra Alli® won’t speed up your weight loss; it only increases your risk of serious side effects.Getting the dose of Qsymia® that works best for you is part of the process. And Kane cautions, “Some obesity medications at higher doses can cause more rapid weight loss, but one typically sees weight regain without continuing them indefinitely.” Sustaining weight loss after completing a Qsymia treatment plan requires a holistic approach․ This involves maintaining a healthy diet, engaging in regular exercise, and adopting healthy lifestyle habits․ Continuous monitoring of weight and health markers is essential to identify any potential issues and adjust the plan as needed․ Support groups and ongoing communication with healthcare professionals can provide valuable guidance and encouragement․ The key to long-term success is developing a sustainable lifestyle that supports your overall well-being and promotes healthy weight management․ It’s important to remember that weight management is a journey, not a destination, and requires ongoing commitment and effort․ With an estimated one billion people worldwide to be affected by obesity by 2030, an almost two-fold increase from its 2020 prevalence of approximately 511 million, medical communities and health care providers are adopting evolving perspectives on defining how to qualify patients with overweight or obesity. At Lisse Wellness, we understand that choosing the right weight loss medication can be confusing.Some users experienced a 10% or more reduction in body weight with continued use and lifestyle changes.You should read the medication guide about Qsymia before you take this drug.Phentermine and topiramate must be used along with a reduced calorie diet and exercise plan.Common side effects of Qsymia include dry mouth, constipation, and sleep disturbances.Medicare Part D is the part of Medicare that helps cover prescription medications, including both brand name and generic.It’s important to let your prescriber know about your medical history and other medications you’re taking prior to starting Topamax.Adverse events that occur with the combination therapy are in line with the known side effect profiles of the constituent drugs; teratogenicity, a slight increase in heart rate, psychiatric and cognitive adverse effects, and metabolic acidosis are concerns. Injectable weight-loss medications, such as Wegovy (semaglutide), are getting a lot of attention lately. When combined with healthy lifestyle changes, it can help reduce appetite, support long-term weight loss, and improve related health conditions. “I built healthy habits with coaching and lessons that make me confident I can maintain my weight loss long term.” If you're ready to start your weightloss journey, consult with a healthcare professional to see if Qsymia is rightfor you. It is important to discuss any concernsor side effects with your healthcare provider. It is important to workclosely with a healthcare professional to determine the appropriate durationof treatment. Qsymia not only helps with weight loss but also improves body composition. Clinicalstudies have demonstrated that individuals taking Qsymia experienced greaterweight loss compared to those taking a placebo. Similarly, you may lose weight on a crash diet, but you're likely to regain it when you stop the diet.We are the most trusted and caring provider of online prescriptions, supplements, and services in the pursuit of making a healthier new you!However, Rogers notes that phentermine is technically a kind of amphetamine, which is a controlled substance that may pose a risk of abuse in some people.Achieved 20.7% weight loss in the STEP UP obesity trial, and 18.7% regardless of treatment adherence.Some people have had suicidal thoughts and behaviors while taking other weight loss medications.More clinically significant side effects include palpitations, tachycardia, and hypertension.22Aside from journalism, her passions include running, fitness, and healthy living. Additionally, fiber helps to promote the growth of healthy gut bacteria, which is essential for supporting immune function, reducing inflammation, and regulating hunger and satiety hormones. By including a source of protein and healthy fat at each meal, individuals can help regulate hunger and satiety hormones, support muscle growth and maintenance, and promote overall health and well-being. Additionally, carbohydrates alone do not provide the necessary building blocks for muscle growth and maintenance, which is essential for supporting metabolism and overall health. Carbohydrates provide energy for the body, but they can also cause blood sugar spikes and insulin resistance if consumed in excess, particularly if they are refined or processed. The manufacturer savings card for Qsymia offers discounts for cash-paying consumers who self-pay and those with insurance plans that don’t cover the medication. GoodRx has an exclusive manufacturer discount for Qsymia that can help you pay less for this medication. In fact, prior authorization is required for about 1 in 3 people covered by a Medicaid plan — and most people covered by commercial plans not purchased through an ACA marketplace. As with drug interactions, it’s best to discuss the risks of Wegovy and Qsymia with your healthcare team. One study found that Qsymia reduced blood pressure better than phentermine alone or a placebo (pill with no medication in it). But both medications are considered very effective weight-loss options. About 70% of participants lost at least 5% of their initial body weight after taking the highest Qsymia dose for 1 year. Targeting these receptors also reduces appetite and helps people manage their weight. BMI (body mass index) is a measure of your weight in relation to your height. This blend of community, expert coaching, and easy-to-use tools makes it simpler to stay motivated, stay accountable, and achieve your weight loss goals. The CSIRO Total Wellbeing Diet is first and foremost a food-based weight loss program — your results come mainly from following the scientifically designed meal plans. But oral and injectable Wegovy provide similar weight-loss results. This has many people looking at other options. You’ll also get access to all of Noom’s tools and trackers to help you reach your goals at a healthy pace. You’ll be paired with a clinician who can find the right medication for you, prescribe it if needed, and design a plan that works. The high-dose treatment group experienced significant reductions in all secondary endpoint measurements compared with those receiving placebo. Primary outcomes were the percentage of change in body weight and the proportion of patients achieving at least a 5% weight reduction. The hard gelatin capsule contains immediate-release phentermine and extended-release topiramate beads.6,7 Because earlier studies used the designation phen/tpm cr (controlled release), CR is used for the generic drug name in this article. The doses approved for weight reduction are lower than either agent when used for its current indications. Phentermine is only approved for short-term usage, while Qsymia is approved for long-term use. This offer is only available to patients trying the WAYT-less™ Program for the first time. Nu Image Medical does not make any claims as to the safety, efficacy or intended use of these compounded drug products. By closely monitoring any potential side effects and following your doctor's guidance, you can safely incorporate Qsymia into your weight loss plan and achieve your desired goals while maintaining your overall well-being. It is important to inform your doctor about all medications you are taking as Qsymia may interact with other drugs. Before using Qsymia, it is crucial to discuss potential side effects and disclose all medications you are currently taking with your doctor. Qsymia, released in September 2012, is a cutting-edge appetite suppressant medication that offers promising results in weight loss. Human studies including children have demonstrated the effect of Metreleptin on improving hyperglycemia, hypertriglyceridemia, and hepatic fatty steatosis in patients with lipodystropy characterized by congenital or acquired loss of adipose tissue 84, 85. Ghrelin O-acyl transferase (GOAT) has been considered the main enzyme responsible for acylation of ghrelin, and emerging as an important molecule in treating obesity . Gastrointestinal disease and loss of appetite were more frequent in the MEDI0382 group than in the placebo group. The drug shall be discontinued when the patient’s body mass does not decrease by at least 5% of the baseline weigh. In 12 weeks after the use of the maximum dose, the treatment efficacy is analyzed. In 12 weeks after increasing the dose of the drug, evaluation of obtained results should be conducted. These tests help find out current health condition and identify the cause of obesity. The healthcare provider may further perform blood tests, including lipid panels, thyroid function tests, blood sugar tests, and liver function tests. Various researchers elucidate obesity as uncurbed growth of fat which results in various health issues. This product image provided by Vivus Pharmaceuticals Inc. shows bottles of Qsymia, the company’s anti-obesity drug. “My doctor recommended Noom after I was frustrated trying to lose weight. “Noom provided me with the medication which I could not get through Medicare. “Clinicians who understand how supportive medication can be is one of the best parts of Noom! “Noom has taught me that every day is a new chance to make better, healthier choices. If you and your doctor decide it’s time to stop Qsymia®, they will help you gradually taper off the medication to keep you safe. After you take this dose for 12 weeks, your doctor will check to see how much weight you have lost. Take phentermine and topiramate exactly as directed. Take phentermine and topiramate at around the same time every day. Topiramate is in a class of medications called anticonvulsants. Phentermine is in a class of medications called anorectics. Other alternatives include oral medications such as Qsymia or Contrave. In the Northwest, coverage is more accessible for weight loss if criteria are met. In 2026, coverage for innovative drugs continues to evolve, focusing on evidence-based treatments. In this post, we’ll explore what Qsymia is, how it works, and what you should know before incorporating it into your weight loss strategy. Founder of Missouri Metabolic Health, a telehealth company that treats and prevents metabolic conditions through evidence based medicine, weight management and lifestyle optimization. It is recommended that you speak with your doctor about this, because he or she might have to adjust your diabetes medications. GoodRx can help you navigate between GoodRx coupons and copay savings cards to save money on your prescription. There are ways to save on Qsymia, which is available as a brand-name medication as well as a lower-cost generic. The combination raises your risk of side effects, such as dizziness and confusion. A different medication may be a better option for you. If your side effects worsen or don’t improve over time, let your prescriber know.