The presence of multiple subtypes of antiobesity drugs targeting different mechanisms of action should aid in avoiding therapeutic inertia and pursuing this goal , if indicated by future guidelines. Probably the future of obesity treatment will be accompanied by several changes as observed for other chronic conditions. This was highly expected, since although sibutramine is not a catecholaminergic drug as phentermine, it acts centrally, inhibiting the reuptake of both serotonin and norepinephrine, reducing the appetite and enhancing indirectly caloric expenditure . Additionally, Topamax has been demonstrated to enhance insulin sensitivity in patients on antipsychotic drugs such as olanzapine (Zyprexa).The mean dose of topiramate was 195 mg/day (range, 100–375 mg/day).As with topiramate, your actual cost can vary depending on your pharmacy and any insurance coverage.Topamax (topiramate) is an anticonvulsant and neurological medication approved by the U.S.Your care team will tell you how much medication to take.Most people start noticing weight loss within the first 4-8 weeks of taking topiramate, topamax weight loss.Standard starting doses can range from 25 to 50 milligrams per day and may be increased to 100 milligrams or more.Orlistat, approved in the US in 1999, has been the best studiedantiobesity drug among people with hypertension. Although higher dosages of Topamax increase the likelihood of adverse effects, they often lead to greater weight loss. However, it is paired with phentermine in Qsymia, a weight-loss drug that has FDA approval. Qsymia is an FDA-approved weight-loss drug, in contrast to Topamax. The FDA has authorized Contrive as a weight-management tool for people who are obese or overweight with a weight-related medical condition. Semifluid is an ingredient in the name-brand drug Segovia, which is specially authorized for the treatment of obesity in people without type 2 diabetes. We do not suggest using topiramate specifically as a weight-loss drug, but that it should be considered as an option if there exists an indication to use a drug of its class. We also did not have baseline weight for each subject to know how much weight had been gained on treatment with the mood stabilizer prior to topiramate treatment. Her weight before topiramate treatment was 196 lb (88 kg). Her weight was declining; her weight before topiramate treatment was 180 lb (81 kg), which decreased to 162 lb (73 kg) by month 3. Let’s talk about the Topamax weight loss benefits that might just be your new best friend on this journey! It’s essential to consult with your healthcare provider to determine the best alternative for your individual needs and health status. Your healthcare provider will closely monitor you for signs of dependence or addiction. Taking more than the recommended dose or using the medication for longer than intended can increase the risk of physical dependence and withdrawal symptoms. Weight management is a complex issue with far-reaching implications for overall health. The mechanisms behind Topamax-induced weight loss aren't fully elucidated‚ but several hypotheses exist. Not everyone taking Topamax experiences significant weight loss‚ and the degree of weight change differs widely among individuals. While weight loss is a reported side effect‚ it's crucial to understand its variability. women's health Pursuing a healthy lifestyle is another robust and reliable method to attain and maintain a healthy weight while shedding excess pounds. Consulting a healthcare provider becomes imperative if severe side effects occur while you're taking Topamax. Embarking on a weight loss journey with Topamax requires awareness of its possible adverse effects. Of the 22 studies reviewed, the average increase in muscle strength (1, 3, or 10 repetition maximum RM) following creatine supplementation plus resistance training was 8% greater than the average increase in muscle strength following placebo ingestion during resistance training (20 vs. 12%).Naturally, all medications have their risks and side effects and, as clinicians, we are always weighing the risks and benefits of therapy with the risks and severity of the disease.However, the dosage and frequency that would work best for you will be decided by your healthcare professional.However, some individuals have reported losing significantly more weight, up to 20-30% of their initial body weight.A doctor can help determine whether Topamax is a suitable option and monitor for potential side effects.However, Rogers notes that phentermine is technically a kind of amphetamine, which is a controlled substance that may pose a risk of abuse in some people.The maximum dose for weight loss can reach up to 200 mg per day, depending on the healthcare provider’s assessment. Warning Signs to Report to Your Doctor Given the evident gap in data regarding the use of topiramate for weight management therapy in youth, we conducted a case series of pediatric patients with severe obesity on topiramate therapy from a multidisciplinary weight management program at a single, urban, tertiary children's hospital. Topiramate is a medication that has been demonstrated to cause weight loss in adults with obesity as well as in children prescribed the drug for alternative indications. Regular monitoring by a healthcare professional is crucial to manage potential risks and discontinue the medication if side effects become intolerable. These medications should be used as part of a comprehensive weight management strategy that includes lifestyle modifications, such as dietary changes, regular exercise, and stress management. They mimic the effects of the naturally produced hormone, GLP-1, released from cells in the gut to regulate blood sugar and slow food movement through the gut. Topiramate may not benefit people with depression, so Bupropion or Contrave may be more appropriate for these patients. The participants were given different doses of bupropion in combination with a calorie-restricted diet and regular exercise for 24 weeks. They found that people taking topiramate lost an average of 5.3 kg (~11 lbs) after 16 weeks. Ask your doctor if you have any questions about participating in the program or how to get your medication. You can only receive the medication from a pharmacy that participates in the program. Your doctor will tell you how to decrease your dose gradually. In some cases, the medication may simply stop working due to individual variations in response to the drug. With proper use and guidance, Topamax can be a valuable tool for achieving and maintaining weight loss. The effectiveness of Topamax for weight loss may vary depending on individual factors, such as starting weight, diet, and exercise habits. Best Weight Loss Clinic Near Malegaon, Nashik This is only from two days of taking this wonder drug So I took 50mg hoping to get some relief even if it only for a few hours, but I have a feeling that my body is going to reject it like it did the night before. But my research only dove into the treating people with depression with Topamax and the adverse effects. These are the side effects so far after day one on Topamax will continue tomorrow and as the day progressed some got added. Increase of dose is an increase in prescription equals increase in the wallets. Is Philadelphia Cream Cheese Healthy? An Ingredient Analysis But here’s the thing – doctors can still suggest topiramate weight loss. There are certain tips that you must keep in mind while consuming topiramate for weight loss. This unexpected side effect got folks curious, topamax weight loss. Its natural umami flavor satisfies cravings for savory snacks, reducing the temptation to reach for unhealthy chips. Seaweed snacks are a game-changer for anyone looking to lose weight without sacrificing flavor or nutrition. In this article, we’ve rounded up 15 unique, dietitian-approved snacks that are as delicious as they are nutritious. Losing weight doesn’t mean giving up on flavor or feeling hungry all the time. The card’s wide acceptance at pharmacies throughout the United States and its lack of limitations regarding age or pre-existing health conditions make it particularly beneficial. NiHowdy steps in with an exceptional prescription discount card that excels by providing substantial savings and rewards on drugs such as Topamax. When used complementarily with pharmacological interventions, it provides the energy necessary for physical activity and boosts the likelihood of long-term success in managing one's weight. Should sudden vision problems or eye pain arise, immediate medical intervention is necessary. What are some common side effects of Topamax? Almost three-quarters of individuals with hypertension in the US areoverweight or obese ; correspondingly,higher rates of hypertension are observed in individuals with obesity compared tonormal-weight individuals . Much of the increased morbidity andmortality in individuals with obesity is due to adverse metabolic effects of adiposetissue. In addition, relying solely on Topamax for weight loss can lead to a false sense of security and may make it more difficult to maintain weight loss in the long term. It is important to regularly follow up with a healthcare provider to assess the effectiveness and safety of Topamax and to determine whether it is still necessary. It is also not recommended for people who are taking certain medications, such as antidepressants or blood thinners. Oligo- or hypohidrosis which is the decreased ability to cool the body by sweating is thought to also occur due to carbonic anhydrase inhibitory activity or by inhibition of aquaporin 5 in sweat glands.64–66 In addition to paresthesias, the carbonic anhydrase inhibitor activity of topiramate can contribute to a metabolic acidosis and type 3 renal tubular acidosis.62,64–66 However in the metabolic acidosis, plasma bicarbonate levels are seldom less than 18 mM. Table 2 details some of the observed, reported and putative modes of action of topiramate based on in vitro, as well as in vivo animal based trials. Based on this information, it could be concluded that this agent probably has a very low potential for actual physical/physiologic dependency. In addition to a healthy, balanced diet and lifestyle modifications like increasing physical exercise, medical practitioners may advise these drugs. This article will look at topiramate’s effectiveness as a medication for weight loss, how it works, and things to think about before taking it. The FDA has only approved Topamax for weight loss when used in conjunction with phentermine. As a result, several studies have evaluated Topamax’s potential as a weight loss tool. However, it’s essential to maintain healthy diet and exercise habits to maintain weight loss over the long term. Your body temperature could increase to dangerous levels, which may lead to heat stroke. This medication can cause you to sweat less than normal. Do not take this medication close to bedtime. Higher topiramate dosages are often linked to a higher chance of negative side effects. Dizziness and impaired coordination are side effects of topiramate. The U.S. Food and Drug Administration (FDA) authorized topiramate in 1996 for the treatment of epilepsy and specific forms of seizures. As previously indicated, higher dosages appear to produce greater weight reduction but may also result in more adverse effects. According to studies, you usually lose more weight the longer you take Topamax. Keep this medication in the container it came in, tightly closed, and out of reach of children. Call your doctor if you have any unusual problems while taking this medication. Do not take a double dose to make up for a missed one. Skip the missed dose and take your usual dose the next morning. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Certain groups might have an increased risk of developing health problems. Doctors only prescribe Topamax to people after checking their medical history. Not everyone reacts well to the active ingredients in this antiepileptic drug. They can perform medical examinations to ensure you’re suitable for it. It’s actually a seizure med that makes some folks lose weight. Your doctor will find the right amount for you based on how you respond and any side effects. A common target dose is 100mg to 200mg daily, split into two doses. It might also change how your body handles fats and sugars. Any form of medication can give you side effects from each dosage. Talk to a doctor if you don’t experience weight loss after 12 weeks. You should take a Topamax capsule once a day in the morning to see weight loss results. A placebo or low dose might not suppress your appetite since it doesn’t contain topiramate. A reduced body mass index naturally happens a month into the course of medication. The fact that another fixed drug combination agent; naltrexone sustained release and bupropion sustained release; trade name Contrave is currently undergoing FDA review for use in obesity management (possible approval pending the results of ongoing cardiovascular safety trials) is encouraging and indicative of this evolving trend. The success of the phentermine topiramate-ER combination in the clinical therapeutics of obesity could however extend beyond all the aforementioned. Overall the clinical results of the trials thus far completed for the fixed drug combination of phentermine and topiramate-ER give reason for measured optimism. Further analyses of other cardiometabolic surrogates including blood pressure, lipid profiles and fasting glucose showed no statistically significant benefits though the trends observed suggested minimal improvements.47 Beyond weight loss however the treatment groups of the cohort also demonstrated significant improvements in waist circumference measures suggesting possible diminution in visceral fat depots. Results showed that all the topiramate groups showed an increased amount of weight loss and all were significant when compared to placebo. Additionally, it has gained attention for its off-label use in treating conditions such as bipolar disorder and weight management, making it a versatile option for healthcare providers. Topamax emerges as a multifaceted medication boasting significant implications in both seizure management and weight loss. Before delving into the weight loss aspect, it’s essential to grasp what Topamax is and how it works within the body. In this article, we will explore the scientific mechanisms behind Topamax’s weight loss effects, its impacts on appetite and metabolism, and the overall implications for use in weight management. For many individuals, especially those struggling with obesity or weight loss resistance, this side effect can present a significant incentive to consider this medication. It is also not recommended for people who are taking certain medications, such as antidepressants or blood thinners.Pregnant or breastfeeding women should also avoid taking Topamax, as it can harm the fetus or baby. In clinical trials, participants typically started to see significant weight loss within 2-4 weeks of starting Topamax.It is important to remember that Topamax is a tool to aid in weight loss, but it is not a quick fix. It belongs to a class of medications called anticonvulsants, which work by reducing the abnormal electrical activity in the brain. Topamax, generically known as topiramate, is a medication primarily used to treat epilepsy and prevent migraines. With Topamax, monitoring might be less frequent, but tracking progress and addressing any potential side effects is equally important. Whether using phentermine or Topamax, integrating a healthy diet and regular exercise is essential. At our LA clinic, we tailor combination therapies to meet individual needs, ensuring you receive a balanced and practical approach to weight management. The price of Topamax® can vary widely depending on whether you fill a brand-name or generic prescription, the strength of the dose, and your pharmacy location. These steps worked hand in hand with the medication to make results more consistent and easier to maintain. You can also find both as generic topiramate, which is often much cheaper. Improve your health and see it in your biomarkers. Start low to dodge dizziness, say topamax weight loss reviews. Studies show users average 5-10% body weight loss over six months. In topamax weight loss reviews, users often note steady drops without extreme hunger. It is important to consult with a healthcare professional before considering the use of Topiramate during pregnancy or while breastfeeding to evaluate the potential risks and benefits. One of the primary reasons why glucomannan is added to natural alternatives of Topiramate is its potential for weight management. Unlike traditional beef jerky, it’s leaner, with less fat and fewer calories, making it a better choice for weight loss. Pickled vegetables are more than just a tangy treat—they’re a secret weapon for weight loss and gut health. Although several studies have evaluated the combined effects of creatine supplementation and resistance training on muscle strength and weightlifting performance, these data have not been analyzed collectively. We welcome continued dialogue as to best practices in treating patients for weight loss maintenance and encourage more research on this extremely important topic. The ASBP recently published Overweight and Obesity Evaluation and Management guidelines, which address various issues related to the treatment of obesity. Talk to your healthcare professional if you experience unwanted physical changes after you start to take topiramate.Results showed that all the topiramate groups showed an increased amount of weight loss and all were significant when compared to placebo.This combination, marketed as Qsymia, is approved by the FDA specifically for weight loss.Clinical studies support the use of Topamax in sustaining weight loss over time, showing that it outperforms alternative weight loss methods in terms of both efficacy and tolerability.While it has been shown to be effective for weight loss in clinical trials, its primary indications remain epilepsy and migraine prevention.He implements the most advanced, state-of-the-art technology and treatment options. Weight loss with Topamax is not guaranteed, as individual responses to the medication can vary significantly. Common side effects of Topamax can include cognitive issues such as difficulty concentrating, memory problems, fatigue, and dizziness. It belongs to a class of drugs known as anticonvulsants, which work by stabilizing electrical activity in the brain. Since it is a retrospective trial based on medical records, informed consent was waived. No datasets were generated or analysed during the current study. This study received no specific grant from any funding agency. All authors revised and approved the final version of this manuscript. While on Topamax, you may need to visit your doctor often to make sure that you are not developing any side effects. Your doctor may prescribe Topamax (generic name topiramate) to help reduce food cravings and your appetite. This article was medically reviewed by Sarah Gehrke, RN, MS. Sarah Gehrke is a Registered Nurse and Licensed Massage Therapist in Texas. For more information on Topamax for weight loss in Nashville, TN, consult a healthcare professional to discuss potential risks and benefits. It also poses a potential cardiac risk, especially when used in combination with other weight loss medications. Topamax is sometimes combined with other weight loss drugs, such as phentermine, to enhance weight loss effects. While it is not an FDA-approved drug for weight loss alone, it is sometimes prescribed off-label for overweight adults and obese patients. Always consult with your healthcare provider before starting any new supplement, especially if you have pre-existing medical conditions or are taking prescription medications. He implements the most advanced, state-of-the-art technology and treatment options. Our expert team will help design a personalized plan that’s right for you, guiding you every step of the way to a healthier, happier you. We believe that financial barriers should never stand in the way of achieving your health goals. At Hormone Replacement Therapy LA, we work with patients to explore cost-effective solutions and help navigate insurance coverage to ensure they receive the care they need. Transparency is key to optimizing your treatment plan safely. Weight loss typically starts within weeks but may take months for significant results, depending on dosage and lifestyle.These medications present viable options currently under investigation through clinical trials.In the end, topiramate and Qsymia® can both be good options if you’re looking for medical support with weight loss.Other studies have shown that Topamax reduces food intake by its interaction in the hypothalamus in the brain’s appetite center, as well as stimulating energy expenditure directly.Topamax suppresses the activity of the enzyme carbonic anhydrase in the body.With this, using Topamax for more than 200 mg may result in drastic weight loss.We’ve explored how Topamax can be a game-changer, not just by aiding weight loss but also positively impacting your overall health. Will he say that’s a normal reaction and it will go away with time and continue treatment. Also to add to it seizure drugs can make you lose your memory and your hair, say posters on the drug rating site askapatient.com An April article in JAMA found seizure drugs linked to 26 suicides, 801 attempted suicides, and 41 violent deaths in just five years. All seizure drugs increase the risk of suicidal thoughts and behaviors according to their mandated labels. Why would you take an epilepsy seizure drug for pain? The U.S. Food and Drug Administration (FDA) authorized topiramate in 1996 for the treatment of epilepsy and specific forms of seizures.The study group using Topamax had a higher degree of weight loss compared to placebo-treated patients.Previous trials of lithium carbonate and divalproex resulted in lack of response to either alone or to the combination; therefore, a trial of topiramate was considered.Topiramate—sold under the brand name Topamax or in its generic form—is a prescription drug, meaning that you must have a written order from a licensed healthcare provider to get it.A healthcare professional can monitor your progress and adjust the tapering schedule as needed to minimize the risk of adverse effects. A Dietitian’s MyBody App Review: Results, Features and More Strict diet plans can lead to unhealthy food relationships, contributing to eating disorders. Supplements may boost metabolism and energy levels, while disciplined diets and exercise can improve overall health and fitness. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. Even though the road to recovery may be difficult for some patients, it is important to seek help as soon as possible as this could save you or your loved one’s life. Talk with your doctor about how long you have taken Topamax as well as your topiramate dosages, as these factors may affect what kind of center is right for you. The price of topiramate varies depending on which of the brand names you are planning to buy.The findings of this small cases series seem to indicate that use of topiramate and metformin can achieve clinically significant weight loss prior to surgery in patients with a BMI ≥ 50 kg/m2.Topamax emerges as a multifaceted medication boasting significant implications in both seizure management and weight loss.Most of the combinations used in clinical practice do not have, or have few studies which support them, but may be carefully used in clinical practice, customizing their use according to patients’ characteristics, while new studies or new drugs are not available.This snack is perfect for those moments when you need a little pick-me-up but want to stay on track with your weight-loss goals.While the phentermine-topiramate combination is widely used in the United States, with a total weight loss ranging from 8 to 10 kg depending on the dosage 9, 10, it is unavailable in Brazil.The regulatory agency expanded the drug’s uses to include migraine prevention in 2004. Antiobesity medications are recommended for individuals with a body mass index (BMI) ≥ 30 kg/m² or ≥ 27 kg/m² with one or more comorbidities. In the end, topiramate and Qsymia® can both be good options if you’re looking for medical support with weight loss. In clinical studies, many people lost an average of 8 to 10% of their body weight in about 6 months, compared to about 6% with topiramate. Here’s some more information about how the dose of Qsymia® is managed based on your weight loss pace and side effects. In clinical trials, when topiramate was used for weight loss, people lost an average of 5 to 9% of their starting weight over six months, depending on the dose. They can help you explore alternative medications, supplements, or lifestyle changes that are safe and effective for achieving your weight loss goals. If Topamax is not effective for weight loss or you’re experiencing unwanted side effects, there are alternative weight loss medications and strategies available. If you’re experiencing side effects from Topamax, it’s crucial to consult with your healthcare provider before stopping the medication. Remember, weight loss is a journey, and it may take some trial and error to find the right combination of medications, diet, and lifestyle changes that work for you. However, the reported weight loss is influenced by various factors, including starting weight, dosage, adherence to prescribed medication, and lifestyle adjustments. Other early side effects, such as dizziness, drowsiness, or nausea, might interfere with daily routines, potentially impacting exercise and dietary choices, indirectly affecting weight loss. The National Institutes of Health caution that people should use prescription weight-loss medications only if they are at increased risk of health problems because of their excess weight. "Topiramate has a substantial effect on weight loss, at least comparable to the weight loss that other anti-obesity drugs induce," Kramer said. However, the authors found that patients were nearly two times more likely to stop topiramate treatment because of side effects than were those receiving placebo. In general, weight loss on Topamax tends to be most rapid in the first 3-6 months, with weight loss slowing down over time. A doctor can help determine whether Topamax is a suitable option and monitor for potential side effects. While it has been shown to be effective for weight loss in clinical trials, its primary indications remain epilepsy and migraine prevention. However, some individuals have reported losing significantly more weight, up to 20-30% of their initial body weight. Topiramates use in children older than 2-years is well-established in the treatment of epilepsy and usually well tolerated, although there is a higher incidence of metabolic acidosis in younger patients.10,64 Topiramate has been shown to be teratogenic in animal studies.70 In humans there is an increased risk of oral clefts, and because of this the medication has a category D designation and should absolutely not be used in pregnant women. Several of the adverse effects of topiramate may be related to its inhibitory effect of carbonic anhydrase.65,66 Paresthesias of the distal extremities and periorbitally are a potential side effect as they are with other drugs with carbonic anhydrase inhibiting activity, and may possibly be relieved by potassium supplementation. Despite some of the potential issues with this medication however, phentermine remains the most commonly prescribed anti-obesity agent in the United States and much of the world and has remained so for several decades. Because of this, it is not a surprise that phentermine is commonly prescribed clinically for longer than the 12 weeks recommended in its package insert.21,35,36,38,39,51,54,59 It is recommended that such patients though be closely monitored for the development of potential side effects (particularly elevated blood pressure and tachyarrhythmias) while on therapy. A persistent challenge continues to be correctly identifying initially those patients who will respond best to this medication as an adjunctive intervention in their chronic weight management. A healthcare provider will recommend a reduced-calorie diet and exercise while taking this medication. She said it is important, however, for patients to understand the drug's known possible side effects and to be aware that it may have uncommon side effects that researchers have not yet observed. "We have so few pharmacological options for the treatment of obesity that I believe topiramate can be a useful tool together with diet and exercise." The duration of treatment varies based on patient response. Pregnant women and those taking birth control pills or oral contraceptives should consult a health care provider before using Topamax. It also affects metabolic parameters, potentially increasing calorie burn. Self-medication or unsupervised use can lead to serious complications. The effective treatment of epilepsy with topiramate may take two to four weeks. Although you can take it whenever you choose, it’s best to take your doses at the same time every day. These could include the more typical medication side effects of indigestion, nausea, and stomach pain. Discuss your options for birth control with your healthcare practitioner. Topiramate should only be taken as directed by a healthcare professional. Instant Hydration Review: Healthiest Electrolyte Brand? By suppressing appetite, increasing feelings of fullness, and improving insulin sensitivity, Topamax can aid in significant weight reduction. Rare but serious side effects of Topamax include kidney stones, glaucoma, and metabolic acidosis. Topamax is not a magic pill, and individual results may differ depending on factors such as diet, exercise, and overall health. This is achieved through its effects on the brain’s reward system, which is responsible for regulating food pleasure and satisfaction. Those who are being treated for epilepsy may require a dose of up to 400mg per day, whereas a patient with migraines may only need 25-60mg. When a doctor prescribes Topamax to a patient, the dose that is given is largely dependent upon the condition that is being treated. In recent years, Topamax has also been prescribed to those who are struggling to lose weight. Even though Topamax was initially developed to treat epelectic seizures, it is frequently used to treat other medical conditions. While there is still a lot left to discover about how topiramate works, it is highly effective in reducing the occurrence of both seizures and migraine headaches for sufferers. Additionally, larger dosages appear to cause greater weight loss.In addition this clinical trial demonstrated a 76% reduction in new onset type 2 diabetes in the maximum dose treatment group.Author GIU has served as a speaker for Vivus Pharmaceuticals (Mountain View, CA, USA) in the past for clinical lectures to clinical practitioners on the use of Qsymia in obesity therapeutics.Thus, many patients with an underactive thyroid search for other options for weight loss help, including diet, exercise, and medication.Each medication has unique benefits that, when combined, may enhance weight reduction outcomes.Weight loss with Topamax can be gradual, so be patient and committed to your treatment plan.This article is for informational purposes only and does not constitute medical advice.The increasing pressure to conform to societal beauty standards can lead to the inappropriate use of medications‚ potentially causing harm. A physician or other healthcare provider may prescribe Topamax (topiramate) off-label to help patients lose weight. However, it’s essential to carefully monitor dosages and potential side effects when combining medications. Combining Topamax with other weight loss medications may increase the risk of side effects or interactions. The continuation or worsening of side effects during this phase could significantly impact the patient's ability to maintain consistent diet and exercise regimens. In the initial weeks, some users report a decrease in appetite, leading to spontaneous weight reduction. This variability highlights the importance of personalized approaches and the role of individual factors in determining response to the medication. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. It is important to get rid of the medication as soon as you no longer need it, or if it is expired. TPM provided a significantly greater weight reduction than the placebo across all treatment groups. The mean percent weight loss from baseline to week 24 was −2.6% in the placebo group and −5.0%, −4.8%, −6.3%, and −6.3% in the TPM groups. After twenty-four weeks of treatment, all participants were tapered off by a 50% dose reduction. Her weight was 180 lb (81 kg) before topiramate was added, and her DSM-IV diagnosis was schizoaffective disorder. Ms. C's medical history included hypothyroidism and weight gain. She denied any side effects from the topiramate. Lithium carbonate was increased to 1200 mg at bedtime, and the other medications remained at the same dosages. This led to further investigation into its potential as a weight loss aid. Topamax, known generically as topiramate, has been a subject of interest for its off-label use in weight loss. Understanding the appropriate topamax dosage is crucial for individuals seeking to leverage its weight loss benefits. The exact mechanism of action of Topamax for weight loss, migraine prophylaxis, and other purposes is unknown. For some people with pre-existing medical issues, topiramate may be dangerous. Birth control pills are among the drugs whose effectiveness may be diminished by topiramate. Consult your doctor about the weight loss proper plan suited for you. Topamax is thought to work for weight loss by suppressing appetite and increasing satiety (feeling of fullness). Topamax (topiramate) is an anticonvulsant medication that is also used to treat migraines and binge eating disorder. This indicates that while they lack FDA approval to do so, they could aid in weight loss. Few drugs have received FDA approval to date for helping people lose weight. Topiramate was also found to have effects on neuropeptide-Y as well as its Y1 and Y5 receptors, corticotrophin-releasing hormone and type-II glucocorticoid receptors in rats in whom its weight loss characteristics were being examined.62,63 Patients should also be counseled regarding the appropriate timing of the phentermine dose since the potential for insomnia is greater if the dose is taken too late in the day. None of these patients exhibited cravings for phentermine or typical withdrawal symptoms that would be expected in a patient abruptly stopping therapy with an amphetamine related medication. Other contraindications for phentermine therapy include use with monoamine oxidase inhibitors, hyperthyroidism, glaucoma, agitation states, pregnancy, and use in patients with known history of drug abuse.55 Obesity pharmacotherapy is new to using fixed drug combinations but promises significant potential.32,33 While the number of available molecular targets for obesity pharmacotherapy increase as well as the number of potential injectable adjuncts for obesity and its comorbidities,6,17,18,20,34 the number of oral agents available for potential fixed drug combinations is significantly more limited. However, each person will react differently to the drug, so your doctor will decide on the right dosage for you based on your medical history and other variables. Each person will have a different ideal dosage of Topamax for weight loss. Additionally, it might cause appetite loss, which can worsen conditions like osteoporosis by causing further weight loss from a lower-calorie diet. Seven teenagers who used topiramate and developed disordered eating were evaluated in one case study. The body mass index (BMI), which calculates a person’s weight about their height, is one such tool. Open and honest communication can lead to adjustments that enhance your overall treatment experience. Do not stop taking the medication without consulting with your provider first, as abrupt cessation can lead to withdrawal symptoms. They may suggest adjusting the dosage, switching to a different medication, or implementing supportive care strategies to alleviate symptoms. Doctors may weigh the benefits against potential risks before recommending it to a patient for this purpose. The medication alters certain neurotransmitter levels in the brain, which can contribute to these changes. While many people think of Topamax simply as an appetite suppressant, its effects on the body are more complex. Medication alone is rarely sufficient for sustained weight management. While Topamax can be a valuable tool, it works best as part of a comprehensive weight loss strategy. The likelihood and severity of side effects often depend on the dose and individual sensitivity.