Many antidepressants are weight-positive (cause weight gain), some are weight-neutral, and at least one is weight-negative (causes weight loss). This relationship can allow for dosage adjustments or alternative medications if one seems like a better fit for the patient. AOMs may counter the effects of metabolic adaptation and prevent weight regain. These programs apply only to self-pay patientsand are not covered by insurance. She notes that there are ways for people to slowly taper off GLP-1s and keep the weight off. A study published in 2024 that compared tirzepatide to semaglutide found that people taking tirzepatide lost significantly more weight than those taking semaglutide. A study published in 2024 found that those taking tirzepatide lost an average of 25.3 percent of their starting body weight after 88 weeks. Finally, Pessah-Pollack notes that Wegovy has a separate indication for reducing the risk of cardiovascular events (such as heart attacks) in people who are overweight or obese and have an established heart disease. If you meet these requirements, Pessah-Pollack explains that it’s important for your healthcare provider to document this, as it can significantly help with getting insurance approval. With strong clinical evidence and growing real world use, these therapies are reshaping expectations for sustainable, healthy weight loss.On average, people taking CONTRAVE lostA lifestyle program may also address other things that cause you to gain weight, such as eating triggers and not getting enough sleep.When you start a Form Health membership, they will ship a personal scale to your home so you can keep track of your weight loss.These medicines are used along with a reduced-calorie eating plan and exercise program.Rebound weight gain refers to the regain of body weight after discontinuing or reducing GLP-1 therapy, often occurring faster than expected.Talk to a healthcare provider online and save on CONTRAVEWww.fda.gov/drugs/drug-safety-and-availability/fda-approves-first-treatment-weight-management-people-certain-rare-genetic-conditions If you don't have enough GLP-1, or if it doesn't work the way it should in your body, a GLP-1 agonist can act like GLP-1 and give your system a boost. It's released when you eat and tells your body to make insulin to control your blood sugar. These medicines are used along with a reduced-calorie eating plan and exercise program. For an adult who is 5 foot 8 inches tall, that's a weight of 197 pounds or more. Rare cases of severe liver injury have been reported in people taking orlistat, but it's not certain that the drug caused those problems. If you don't lose 5% of your weight after 12 weeks of taking Contrave, your doctor may tell you to stop taking it because it's unlikely to work for you, the FDA says. It also can't be mixed with pain relievers or other drugs that contain opioids. Bupropion is approved to treat depression and seasonal affective disorder and help people stop smoking. AstraZeneca, the company that makes Byetta, has a program to help with your out-of-pocket costs. Your immune system could produce antibodies that make the drug stop working. Some people develop an immune system reaction to exenetide. Dulaglutide has been shown in studies to cause thyroid tumors in animals, but it's not yet known if it can cause thyroid cancer in people. Some people may be prescribed up to 4.5 milligrams. But other potential side effects can be more serious. The company that makes Plenity, Gelesis, sells a 4-week supply with a prescription for $98. It's a substance called a hydrogel that's made up of cellulose and citric acid. The company that makes it, Vivus, has a program to help with your out-of-pocket costs. Get regular checks of your heart when starting the drug or increasing the dose. Novo Nordisk is developing an oral version of semaglutide (50 mg)specifically for obesity. It is being studied for use in patients with acquired hypothalamic obesity. It is intended for use with a reduced-calorie diet and is also indicated to reduce the risk of weight regain. If your insurance does not cover CONTRAVE, you can still find savings through the CurAccess™ Patient Support Program. Other ways to request insurance coverage Save on your prescription + get free shipping‡ You also authorize Currax Pharmaceuticals LLC, and its partners, to communicate with you about products, health conditions, co-pay, and financial assistance. With the CurAccess Program, you will pay $99 or less + get free shipping for your prescription for CONTRAVE. If you run into any issues with your insurance, remember that you can instead use the CurAccess™ Patient Support Program to get a guaranteed low price. To determine if coverage is available, your healthcare provider may request a coverage review. If not, you may wish to discuss other coverage options with your healthcare provider. Plus, a simple telemedicine call is all it takes to get medication delivered to his door each month. After 40 years in law enforcement, Brian entered retirement—and quickly found himself struggling with weight gain. In combination with diet and exercise, CONTRAVE helped him get back to his goal weight. Brian’s journey included numerous diets, exercise, and trying a GLP-1 medication before he found CONTRAVE. When consumers hear about the medications being effective for weight loss, they’re desperate to get them, adds Dr. Melanie Jay, director of the NYU Langone Comprehensive Program on Obesity Research. As the regional director for clinical nutrition and weight management at a prominent healthcare organization in Southern California, Dr. Hashmi oversees the development and implementation of cutting-edge nutritional programs and weight management strategies. Some evidence suggests that people with certain other medical conditions should avoid these drugs, too. It depends on your results and side effects. Healthcare researchers are still studying the long-term risks and effects. Alli is the only one that’s FDA‑approved and available over the counter (OTC). For instance, if weight loss slows or you begin to feel fatigued, increasing protein or adjusting meal timing may help. As weight changes and your body adapts, so too may your nutritional needs. It helps preserve lean muscle mass — a critical aspect often overlooked during weight loss, particularly when appetite is suppressed and overall food volume is reduced. A registered dietitian or healthcare provider can help estimate your daily needs, adjusting as your weight changes. Gastrointestinal symptoms — nausea, vomiting, diarrhea, and constipation — are by far the most common side effects of GLP-1 drugs. Moore also addressed concerns about what happens when patients stop taking GLP-1 medications, noting that many experience weight regain. GLP-1s should never be sourced without a prescription or used off-label for cosmetic weight loss purposes. If your Ro provider prescribes GLP-1s, you will pick up your prescription at your preferred local pharmacy. So, whether you’re already taking a GLP-1 or simply interested in seeing if you’d be a good candidate for this type of drug, we’re here to help. At Ascend Medical, we believe in harnessing these advancements responsibly - always centered around your long term health and well-being. Their ability to support appetite regulation, metabolic control, and sustained weight reduction — when combined with structured clinical support - makes them a promising option for many patients. Interactions may occur during or within 14 days following the use of monoamine oxidase (MAO) inhibitors, sympathomimetics, alcohol, adrenergic neuron-blocking drugs, and possibly some anesthetic agents.On Nov. 6, the White House announced that leading GLP-1 manufacturers Eli Lilly and Novo Nordisk will lower prices for the popular medications when they’re purchased through Medicare.People taking the pills lost almost as much weight as those taking the injectable version of the drug.These medications can be an important tool for weight loss by helping to reduce appetite.The FDA classifies the drug as a preventative heart disease medication.She tried other weight-loss methods before discovering CONTRAVE.Prescription weight loss drugs don't work for everyone. Wegovy mimics the effects of GLP-1, reducing hunger and cravings by targeting receptors in the gut and brain. GLP-1 is a hormone produced naturally in the body that helps regulate appetite and food intake by working on both the gut and the brain. All medical services are provided through our affiliated medical group, WeightWatchers Clinic. Rapid urbanization and lifestyle changes are contributing to higher obesity incidence, expanding the addressable patient base. In addition, widespread awareness campaigns and routine screening are supporting early intervention and sustained treatment adherence across the region. Overall, most people taking semaglutide at doses for weight loss (2.4 milligrams) can expect to lose 5 to 15 percent of their starting body weight. The program also utilizes MetabolicPrint, a proprietary prescription engine that identifies health traits that affect your weight, so that your provider can create a tailored treatment plan. During your first video appointment, your doctor and dietitian will develop a personalized weight loss plan, which may include diet, exercise, behavioral health, and FDA-approved brand-name GLP-1 medication. In 2023, it acquired the telehealth company Sequence, now called WeightWatchers Clinic, for its prescription weight loss program, which offers major brand-name GLP-1s. Prescription medications to treat overweight and obesity work in different ways. Prescription weight loss drugs don't work for everyone. Prescription medications can be very effective in helping you lose weight. Tirzepatide is also a GLP-1 medication approved for weight loss. When Will Medicare Cover Ozempic, Other Weight-Loss Drugs? Please contact your local VA/military treatment facility or TRICARE network provider to determine if your benefits include weight-loss medications. Medicare doesn’t cover prescription weight-management medications, but some Medigap and Medicare Advantage plans do. You are encouraged to report negative side effects of prescription drugs to the FDA. Prescriptions require online consultation with a healthcare provider who will determine if a prescription is appropriate.Be careful not to lose muscleIt could provide a welcome alternative for people who do not want injections.With prescription medications, a healthcare professional can weigh all factors affecting the patient’s lifestyle and BMI and monitor progress and side effects.In recent years, the popularity of GLP-1 (glucagon-like peptide-1) weight loss medications has surged, significantly affecting various sectors, including aesthetics and wellness.But after menopause led to steady weight gain and constant cravings, she knew it was time to prioritize her own health.She's also co-author of a new book about obesity with Oprah Winfrey, called "Enough."If you take insulin for diabetes, let your doctor know before you take phentermine, as you may need to adjust your insulin dose. Wegovy’s oral version of its injectable weight-loss drug is seeing tremendous interest, Novo Nordisk executive Dave Moore told FOX Business on Friday. Novo Nordisk executive vice president of U.S. operations Dave Moore discusses the drugmaker’s newly launched once-daily oral weight-loss pill on ‘The Claman Countdown.’ Learning to eat well while on medication supports sustainable change when the prescription ends. These medications are not designed to be taken indefinitely. GLP-1 medications reduce food intake, which often includes a reduction in protein. While GLP-1s have grabbed a lot of headlines, they are only the latest in a long history of evolving weight loss medications. Some weight management medications are designed for short-term use and others for long-term use. A treatment plan for obesity can comprise multiple forms of treatment, including medications, diet, exercise, and/or surgery. Please contact your local VA/military treatment facility or TRICARE network provider to determine if your benefits include weight-loss medications.Originally developed for type 2 diabetes, clinicians quickly recognized their powerful impact on weight loss; an effect that has led to FDA approval of several GLP-1 therapies specifically for obesity.By taking part in one, you can help doctors learn more about ways to lose weight and keep it off, and you could get early access to the next breakthrough treatment.When you lose a lot of weight in a relatively short period of time, you can end up with loose skin, which translates into wrinkles.Zepbound is approved to treat obesity in adults with a BMI of 30 or greater.While no specific vitamin or supplement is considered a “treatment” for obesity or overweight, certain ones help support metabolic health.If you continue, you will be evaluated for the membership-included medications to see if your Clinician thinks you're a good fit, or choose to pay without insurance for GLP-1 medications.It is being studied for use in patients with acquired hypothalamic obesity. In recent years, weight-loss medications have become increasingly recognized as valuable tools for individuals who struggle with traditional diet and exercise approaches alone. So, making nutrient-rich choices and staying active will help you get the most out of your treatment and maintain a healthier weight. The period of treatment is a window of opportunity to focus on diet quality and physical activity, helping you get the most from your medication while also investing in your long-term health. Key factors include increased awareness of weight loss options, technological advancements in treatment methods, and the influence of social media on personal appearance standards. According to industry reports, the global non-invasive aesthetic treatment market is projected to grow significantly, driven partly by the demand from individuals undergoing weight loss transformations. “I never thought I’d get back to this weight.” She was relentless like that, the woman didn't need no body but an open road, a pen and a couple of sunsets.”― Nikki Rowe Bodies benefit from adequate protein regardless of medication status. Successful long-term outcomes require viewing medication as a training period for new nutritional patterns rather than a temporary solution. The relationship with food rebuilt during medication continues influencing choices for years. One class of drugs called glucagon-like peptide-1 (GLP-1) agonists can treat both obesity, type 2 diabetes , and more. Weight loss drugs may be an option for you if have obesity, which is defined as a body mass index (BMI) of 30 or higher. A previous clinical trial, funded by Eli Lilly, found people lost 24% of their body weight after 48 weeks on the drug. In a phase 2 trial funded by the pharmaceutical company, people lost up to 20% of their body weight after taking the medication for almost a year. An earlier trial funded by the company showed people with Type 2 diabetes lost up to 14% of their body weight with the injection at 36 weeks, while those who took the daily pill lost 10%. For some people diet and exercise alone may not be enough. People with diabetes face higher risk of hearing loss Be careful not to lose muscle One of the most common — and least openly discussed — concerns among people using GLP-1 medications is not weight loss. “Patients considering any anti-obesity medication as a treatment option should be prepared to take these medications long-term — that’s how we see the best outcomes in the scenario for achieving and, most importantly, sustaining all the health benefits achieved,” says Gudzune. But some celebrities and people who may not really need them are using the weight loss medications somewhat inappropriately. “No medication or supplement can counteract the effects of a bad diet.” Regular exercise, good hydration, and quality sleep are other habits crucial for overall health and better weight loss results. But the FDA has approved the same drug as an overweight and obesity treatment under the name Wegovy. The surge in telehealth services has further improved accessibility to weight loss management across diverse population groups. Growing physician acceptance of long-term pharmacological weight management is strengthening prescription volumes across developed and emerging markets. A global shift toward sedentary lifestyles and higher consumption of processed foods has increased the incidence of morbid obesity, encouraging adoption of innovative and effective fat reduction therapies and medications, thereby driving market expansion. The market is largely expanding due to the growing awareness about obesity-linked health risks, which has led to the growing adoption of precise medication with lifestyle management. Contrave side effects In a late-stage trial funded by the pharmaceutical company, people lost 20% of their body weight on average after taking the drug for a year and four months. Some people might tolerate amylin analogs better than GLP-1 drugs, or the new option could help people overcome a weight-loss plateau, Jay notes. Hundreds of medications are needed for the treatment of a chronic disease like obesity, says Dr. Ania Jastreboff, director of the Yale Obesity Research Center. GLP-1 drugs now account for more than 7% of all prescriptions in the U.S., according to Truveta Research, a health data company. This medication can also help with Type 2 diabetes because it helps manage blood sugar levels. Bupropion-naltrexone combines an antidepressant (bupropion) and an addiction treatment drug (naltrexone). Healthcare providers noticed that it also led to significant weight loss. Your healthcare provider can help you understand the pros and cons of this treatment and if it’s right for you. The body does not forget periods of restriction. Rebound weight gain is not inevitable — but it is predictable when the underlying metabolic context is ignored. “That's a safety feature that your body has designed to stop foreign things from getting in your body. If you get it without a prescription, it's called Alli, which has half of Xenical's dose. Orlistat blocks your body from absorbing about a third of the fat you eat. The company that makes it, Currax, has a program to help with your out-of-pocket costs. Rare but serious side effects include an allergic reaction, seizures, liver damage, increased blood pressure or heart rate, and vision problems. In addition to helping with weight loss, GLP-1s, or glucagon-like peptide-1 receptor agonists, have been found to improve heart and liver health and treat sleep apnea in overweight adults. The FDA approved the first GLP-1 pill for weight loss earlier this week, and the oral form of Wegovy is expected in pharmacies in early January 2026. Effectiveness depends on the specific medication and study, but recent reporting on oral semaglutide for weight loss describes meaningful average weight loss in clinical trials and a major convenience advantage. Even modest weight gain can be distressing, affecting self-esteem, body image, and motivation, and it can make it harder to stick with a medication that’s otherwise improving symptoms. Even as the range of weight loss medications has expanded, some drugs have been withdrawn based on their lack of efficacy as well as safety concerns. Currently, these medications are administered by injection, but oral weight loss drugs in the same category may soon follow. Many people experience weight loss plateaus while using GLP-1 medications. While no specific vitamin or supplement is considered a “treatment” for obesity or overweight, certain ones help support metabolic health. Medicare does not cover weight loss drugs. Insurance coverage varies and will affect many patients’ choices about going on weight loss medications. Studies have also evaluated drugs that target metabolic tissues—such as adipose tissue or muscle—to promote weight loss; however, to date, nothing has carried on into clinical practice.” The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. CONTRAVE is not approved for use in children under the age of 18. While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. This progression can help to alleviate side effects, which include gastrointestinal symptoms, headache, dizziness, and fatigue. The net is weighted to keep it below the surface of the water. It is up to the jury to determine how much weight or consideration to give that evidence. How do I get Medicare coverage for Wegovy? But more options are needed, Levy notes, especially since the drugs need to be taken for the long term. “There's a huge pipeline of new medications that are coming,” Dr. Melanie Jay, director of the NYU Langone Comprehensive Program on Obesity Research, tells TODAY.com. Weight loss on these drugs can be significant. The global prescription weight loss medication market revenue surpassed USD 12.38 billion in 2025 and is predicted to attain around USD 40.30 billion by 2035, growing at a CAGR of 12.53%. While opening up about her use of weight loss medication throughout her health journey, which she’s been talking about for decades, she mentioned that she gained 20 pounds last year after temporarily stopping taking it. The use of glp-1s has some people rattled, as many health experts have warned that they're a 'long-term' drug, which oprah seemed to agree with after "testing" her limits last year. Www.fda.gov/drugs/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products/new-drug-therapy-approvals-2022 FDA approves treatment for chronic weight management in pediatric patients aged 12 years and older. FDA approves weight management drug for patients aged 12 and older. Researchers are currently studying several new medications and combinations of medications in animals and people. The table below includes limited information about weight-loss medications. Common side effects include nausea, diarrhea and vomiting. Side effects could include stomach issues like diarrhea, vomiting and nausea. This medication comes as a pill you swallow. You should feel comfortable asking whether your health care professional is prescribing a medication that is not approved for treating overweight and obesity. Some weight management medications that curb appetite, such as phentermine, are approved by the FDA only for use for a few weeks. Some, but not all, insurance plans cover medications that treat overweight and obesity. In the past, some weight management medications were linked to serious health problems, and they were removed from U.S. markets. URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. These medicines are available only by prescription. Your body may not absorb important vitamins, minerals, and other nutrients from food while you are using orlistat. You can also buy orlistat without a prescription under the name Alli. Despite this side effect, most people tolerate this medicine. Curious about CONTRAVE and weight loss? If you’re thinking about adding a weight-loss pill to support your weight-loss efforts, consider asking your healthcare provider about a weight-loss medication that’s FDA approved. The nutrition strategies that complement weight-loss medications ultimately serve health independent of pharmaceutical support. Trends have emerged in the grocery aisle where products are marketed with buzzwords implying they are ideal for people using weight-loss drugs. For more information about the importance of diet and lifestyle support when taking weight loss medications see our current position and guidance document People taking weight-loss medications may inadvertently eat less protein simply because they feel fuller sooner, which can compromise muscle maintenance. Protein plays a central role in weight management and overall health. The right approach balances medication benefits with nutritional wisdom that supports metabolic health, energy maintenance, and gradual habit development for life after treatment. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Sign up to get the latest news about CONTRAVE, weight-loss tips, special offers, and more. Many weight-loss pills and supplements are out there, but not all work the same. In just a few minutes, you'll receive personalized results that you can share with your healthcare provider. White also worries about the possibility of undisclosed chemicals being added to the patches. “We are not a pharmaceutical company and we do not make any medical claims.” “It creates a lot of demand, and it creates openings for people to exploit that demand,” Jay tells TODAY.com. “Because that term is in a lot of people's consciousness.” PlushCare no longer offers compounded GLP-1 medications, but it now provides all brand names of the medication, including Ozempic. After you reach your goal weight, you’ll move into the maintenance phase, with continuous virtual visits with your care team to help you sustain your weight loss. Once you’ve received your prescription, you can reach out to your health coach at any time via the mobile app. Not only that, but customer support will also help you navigate your individual insurance plan to improve your chances of getting the prescription covered. The company accepts most insurance plans for the cost of medication, but it doesn’t accept insurance for the monthly membership fee or initial consult fee. The pill versions are especially good for “needle phobic” people, Levy says. The lowest doses cost $149 a month for people paying out of pocket, a cheaper alternative to the injectable Wegovy. The once-daily Wegovy pill is already approved and became available in the U.S. in January 2026. The exact neurochemical effects of CONTRAVEleading to weight loss are not fully understood. Weight-loss medications eventually taper or stop, making the nutrition habits developed during treatment critical for maintenance. Gaining clarity on how different weight-loss medications function within broader lifestyle changes can help individuals make more informed, long-term wellness decisions. Sustainable weight management is best supported by balanced nutrition, regular movement, proper hydration, and the appropriate use of medication when needed. Many weight-loss medications can increase sensations of nausea or cause dry mouth, making it especially crucial to sip water consistently throughout the day. If you have diabetes that needs treatment with medicines, you may want to ask your provider about diabetes medicines that often lead to weight-loss. Consider whether the cost, side effects, and the small weight loss you can expect are worth it to you. The amount of weight you are likely to lose with these medicines varies greatly from as little as 5 to 10 pounds (lbs) (2 to 4.5 kilograms kg) to 20% of your body weight or more. While weight-loss medicines can be helpful, the overall weight loss achieved is limited for most people. What Are Macros? The Building Blocks of a Healthier You Access to GLP-1s is only available to people with a BMI of 30 or higher, or 27 and higher with a weight-related health condition like high blood pressure, high cholesterol, or type 2 diabetes. The program offers a holistic approach to weight loss that includes diet, exercise, lifestyle changes, and medication when appropriate. Form Health offers patients with an established primary care provider a personalized weight management plan with access to GLP-1 medications (when appropriate). Additionally, if you’re approved for GLP-1 medications, WeightWatchers will help coordinate care with your insurance provider. These medications can lead to dehydration and muscle loss, so WeightWatchers also provides daily nutrition targets that prioritize protein, water, and fruits and veggies, as well as a daily activity goal to support weight loss. Some people also benefit from methylation testing to understand how their liver processes nutrients and medications. Testing timing depends on your baseline health and how your body responds to the medication. Of people taking CONTRAVE lost at least 10% of their body weight vs 5% with placebo Of people taking CONTRAVE lost at least 5% of their body weight vs 18% with placebo It's important to tell your healthcare provider about all of your medical conditions. What are your goals as it relates to your weight and health? Even without health insurance, you can still pay $99 or less per month for CONTRAVE with the CurAccess™ Patient Support Program. Liraglutide has been shown in studies to cause thyroid tumors in animals, but it's not yet known if it can cause thyroid cancer in people.Researchers are studying many aspects of prescription medications to treat overweight or obesity, such aYou can’t contribute to a health savings account after you enroll in Medicare, but if you’ve already accumulated money in an account, you can withdraw it tax-free at any time for eligible expenses.It's important to understand that GLP-1 medications are not a "magic bullet." They are tools within a broader, medically supervised plan.“Today’s announcement builds upon our … goal of democratizing access to weight-loss medication, which has been out of reach for so many in need,” says Dr. Mehmet Oz, CMS administrator.In addition, tell your doctor that you take GLP-1 drugs if you are having surgery or a procedure that involves general anesthesia.Doctors are studying new treatment strategies to help people lose weight and to stay at a healthy weight.Plenity isn't considered a drug because it's never absorbed by your body.Overall, most people taking semaglutide at doses for weight loss (2.4 milligrams) can expect to lose 5 to 15 percent of their starting body weight. Medicare spent $2.6 billion on Ozempic in 2021 and $4.6 billion in 2022, making it one of the 10 drugs it spends the most on. “With obesity, every insurance and every employer follow their own plan,” she says. The FDA approved the first GLP-1 drug in 2005. In March 2024, the FDA approved Wegovy’s use for adults with cardiovascular disease who are also overweight, which opened the door for Medicare Part D plans to cover it. It was not included among the medications in the November White House announcement. Compounded drugs are not FDA-approved and may carry greater risks than FDA-approved treatments. GLP-1 medications have catalyzed one of the most profound shifts in medical weight-loss care in decades. Like all therapies, GLP-1 medications can have side effects — most commonly digestive symptoms such as nausea, vomiting, or constipation as the body adjusts. Originally developed for type 2 diabetes, clinicians quickly recognized their powerful impact on weight loss; an effect that has led to FDA approval of several GLP-1 therapies specifically for obesity. Prescription medications to treat overweight & obesity. Novo Nordisk has a savings program that may help with your out-of-pocket costs. Less common but more serious side effects include an allergic reaction, problems with your pancreas, kidneys, or gallbladder, and vision changes. Most side effects are generally mild and temporary. They affect energy, confidence, medical risk, and even the ability to stay on psychiatric medications that are otherwise helping. Deciding whether a weight-loss medication is right for you starts with understanding how your mental health, physical health, and daily experience intersect. But now, with the development of GLP-1 and GIP medications, metabolic side effects that have plagued psychiatry are no longer the curse of care. “GLP-1 agonists are also approved for type 2 diabetes,” says Pessah-Pollack, “and if you have this indication separately, it’s important to include this diagnosis when sending your prescription to the pharmacy.” Oprah Winfrey has gone through a noticeable weight loss transformation, but in a new, informative interview, she revealed she actually gained a fairly significant amount of weight during a “test” last year. "it's the same thing - if you are on blood pressure medication, a lot of people are on blood pressure medication, if you stop your blood pressure medication, your blood pressure is going to go up." "i was trying to eat more healthily, but i still put the weight back on," oprah recalled. "i gained 20 pounds because i wanted to test it, because everybody was saying, 'you're gonna gain the weight.' i'm gonna go, 'i'm gonna show them i'm not gonna gain the weight.'" Therefore, the 71-year-old is opening up more and more about how she reached a maintainable place in her life, as well as a sustainable weight loss she can continue managing. If more than 5% weight loss is not achieved after 12 weeks of the maximum dose, the weight loss pill should be gradually discontinued. Combining the two drugs increases efficacy. Interactions may occur during or within 14 days following the use of monoamine oxidase (MAO) inhibitors, sympathomimetics, alcohol, adrenergic neuron-blocking drugs, and possibly some anesthetic agents. Tirzepatide was previously approved to treat type 2 diabetes as Mounjaro, and it goes by that name only in some countries. Like semaglutide, it works by reducing appetite and is meant to be used in combination with diet and exercise to lose weight. This medication is also helpful if you have substance use disorder or if your main issue is sugar cravings. Common side effects include nausea, headache and constipation. Healthcare providers also use body mass index (BMI) as a factor. The Art of Treating Yourself in Life: More About This Simple and Effective Thing What started with Ozempic has become a new era in weight-loss success with blockbuster GLP-1 drugs like Wegovy and Zepbound helping fight obesity. In clinical trials, which compared people randomly assigned to the active drug or a placebo, participants receiving semaglutide or tirzepatide lost 15% to 20% of their body weight on average. A Guide to Weight-Loss Medications covers the science, risks, potential side effects, pros, and cons of this medication-assisted weight loss. Zepbound is approved to treat obesity in adults with a BMI of 30 or greater. It is also semaglutide, but approved to treat type 2 diabetes. All of the medications discussed here are contraindicated for pregnancy. The medication’s cost and side effects will also affect the decision. GLP-1 medications reduce appetite and calorie intake.These side effects are often worsened by skipping meals or eating unbalanced foods.Hundreds of medications are needed for the treatment of a chronic disease like obesity, says Dr. Ania Jastreboff, director of the Yale Obesity Research Center.While it’s not included in the cost of a membership, the optional meal delivery service can be a great benefit for those who find that a lack of time to cook healthy food is a barrier to their weight loss efforts.That kind of weight loss can lead to other health improvements like lowered blood pressure, blood sugar, and some blood fats, and can improve joint pain and sleep apnea.Researchers are currently studying several new medications and combinations of medications in animals and people.Does everyone regain weight after stopping GLP-1 therapy?These are not all of the possible side effects of CONTRAVE. This guide is your trusted resource to help you have informed conversations with your doctor about weight and metabolic health. To lose weight, especially harmful belly fat, combine diet and exercise That’s why developing healthy eating and exercise habits should be part of your treatment plan, too. The weight can come back if you stop the medication. The main benefit is that it helps you lose weight. Find an obesity medicine specialist near you who can assist in finding the best weight loss medications for you. With prescription medications, a healthcare professional can weigh all factors affecting the patient’s lifestyle and BMI and monitor progress and side effects. All weight loss medications work best in the context of a healthy eating plan and exercise. That approaches what people can lose with weight-loss surgery. (See Figure 1, page 5.) These combined effects often result in weight loss. Cleveland Clinic uses the expertise of many specialists to provide personalized medical weight management care. But these medications have risks and side effects. They’ll need to monitor your weight loss and make sure it’s still safe for you to take the medication. It can be frustrating and discouraging when someone repeatedly fails at weight loss or loses only to regain. But it’s important for anyone considering medicated weight loss to discuss the options with a knowledgeable healthcare provider. Here’s what experts say about research on the effectiveness of semaglutide (Ozempic, Wegovy) and a similar GIP/GLP-1 medication, tirzepatide (Mounjaro, Zepbound) and when to consider them for weight loss. Most side effects of GLP-1 drugs are not serious. That compares to about 21% average weight loss for Zepbound, Eli Lilly’s GLP-1 drug. No amylin analogs are approved for weight loss right now by the U.S. The next generation of weight-loss drugs will also mimic another natural gut hormone — amylin, which is released by the pancreas in response to food. Jastreboff is on the scientific advisory boards of several pharmaceutical companies that make weight-loss medications. Choosing a medication to treat overweight or obesity is a decision between you and your health care professional. If you are overweight or have obesity, you might be able to lose weight with a lifestyle program that changes your behaviors and improves your eating and physical activity habits. Your health care professional may prescribe a medication to treat your overweight or obesity if you are an adult with Health care professionals use BMI to help decide whether you might benefit from weight management medications. Combining Mediterranean diet with other lifestyle changes offers extra protection against diabetes At Macro Based Diet, we’ve seen the dramatic rise in interest around GLP-1 medications such as Ozempic, Wegovy, and Mounjaro.Form Health may recommend GLP-1 treatments for adults with a BMI of 30 or above, or for those with a BMI of 27 as well as a weight-related health condition.Looking for a healthcare provider to discuss CONTRAVE with?Not everyone loses weight while taking the medicines.Clinical trials have consistently shown liver benefits from GLP-1 medications in patients with fatty liver disease.Patients lose weight rapidly then struggle to maintain muscle mass, energy levels, and metabolic health without complementary nutrition strategies.These weight loss medications come in a pill you swallow.When people stop treatment, "rapid weight regain" can happen, a 2026 review of studies found. In Phase 2, orforglipron showed weight loss up to 14.7%at 36 weeks. In the OASIS 1 Phase 3 trial, the oral formulation achieved an average weight loss of 15.1%over 68 weeks compared to 2.4% with placebo. In May 2025, they reported 39 new GLP-1 medications in development. The average weight loss in real-world studies is 9%. Nicole was also a senior editor at Weather.com for more than 11 years, covering everything from weather and climate change to health, science, and travel. “You may notice an increase in appetite and less satiety in the short term,” she explains, “and over time, there is the potential for regaining weight, especially if calorie consumption increases.” Pessah-Pollack explains that several things can happen when a person stops taking a GLP-1 medication. This is likely because tirzepatide is a dual GLP-1 and glucose-dependent insulinotropic polypeptide receptor agonist medication. A study published in 2023 found that people taking 15 milligrams of tirzepatide lost an average of 26 pounds. “A patient should always be given lifestyle recommendations when starting a GLP-1, as this will optimize the results when taking the medication,” says Dr. Lofton, who is the director of NYU Langone’s Weight Management Program. To find a safe online pharmacy when purchasing any medication, here are some ways to make sure it’s reputable. Not all companies are reputable, and it’s important to ensure that you won’t simply be given medication without follow-ups with a doctor, and if possible, a registered dietitian. Studies also suggest that GLP-1 has a positive impact in patients with fatty liver disease, and we anticipate using this medication for management of fatty liver disease in the near future.” “This decrease in blood sugar levels plays an important role in managing type 2 diabetes and leading to improved glucose control. While they’re not a treatment for depression, anxiety, or other psychiatric conditions on their own, they can be a helpful part of a whole-person approach that supports both mental and physical health.Patients should consult their licensed healthcare provider before making any changes to their medical treatment, diet, or supplement use."Ozempic face" was coined in reference one of these drugs, although any rapid weight loss can cause it.It's the faster pace of weight loss that occurs with GLP-1 drugs that can make facial changes more obvious.Qsymia has much lower amounts of phentermine and topiramate than when these drugs are given alone.Many people regain most of the weight within 2 years after they stop using it. Luxury consumers seek out the latest technologies and treatments, often opting for high-end clinics that offer personalized care and cutting-edge solutions. Start the program in the WW app, meet with your Registered Dietitian, and join the Clinic community on Connect. Costs may vary depending on insurance. With insurance you could pay as little as $74/month. At this time, our Insurance Coordinators can only work with commercial insurance plans. Undigested fat is then passed through the body. This medication should not be prescribed to a patient who has a seizure disorder or who takes opioids for chronic pain. The most common side effects include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.