While weight gain is a commonly reported side effect of Zoloft, some individuals have reported weight loss while taking the medication. If you’re concerned about weight gain while taking Zoloft, it’s important to talk to your healthcare provider about your options. Our expert healthcare team works closely with each patient to optimize antidepressant therapy while supporting healthy weight goals. They can help you safely change your medication if needed to one that’s less likely to affect your weight. Talk with your healthcare team about your options. Children taking Zoloft are more likely to experience weight loss. Keep in mind that just because weight gain is possible with Zoloft doesn’t mean it will happen to everyone who takes it. Or they may suggest adding a weight-loss medication if it’s appropriate for you. Additionally, staying hydrated, getting enough sleep, and managing stress levels can help support overall health and well-being. This may involve increasing physical activity, eating a balanced diet, and managing stress levels. Additionally, Zoloft may affect the body’s metabolism, leading to changes in energy expenditure and fat storage. Some people may experience significant weight loss, while others may not notice a significant change. Stopping sertraline can lead to weight loss, but it’s not a guaranteed solution for everyone. These factors can lead to significant weight gain, making it challenging to lose weight while taking sertraline. Additionally, Zoloft can cause fatigue, making it more challenging to engage in regular physical activity, further contributing to weight gain. Remember, it is essential to prioritize overall health and well-being, rather than solely focusing on weight changes. Zoloft can cause weight gain or loss in some individuals, but the impact is highly variable and depends on a range of factors. Aim for at least eight glasses of water per day, and avoid sugary drinks that can contribute to weight gain. Incorporating foods that are high in fiber, protein, and healthy fats can also support weight management. Do not let anyone else take your medication. Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking sertraline. Do not flush this medication down the toilet. Place the medication in a safe location – one that is up and away and out of their sight and reach. Keep all medication out of sight and reach of children as many containers are not child-resistant. More than half the people who take an SSRI antidepressant such as Zoloft experience weight gain, but there are ways to manage this side effect. When starting any new medication, including Zoloft, it’s beneficial to discuss potential side effects with a healthcare provider. It’s important for patients to communicate any weight-related concerns to their healthcare provider for tailored advice. Usually, any initial weight changes could correlate with the body adjusting to the medication and the relief of depressive symptoms, which may affect appetite and energy levels. Each person’s response to the medication is unique, making it vital for individuals to monitor their weight and discuss any changes with their healthcare provider. Weight protective factors could be due to its unique mechanism of norepinephrine-dopamine reuptake inhibitor, which has been proposed to suppress appetite and increase energy expenditure (Table 1). Furthermore, those on Bupropion were found to have a 15% decreased risk of gaining 5% of baseline weight when compared to other SSRIs. MAOIs are less commonly prescribed due to drug-drug interactions and dietary restrictions. Some SSRIs, such as fluoxetine had less of an association with weight changes and remained weight neutral . Antidepressant-induced weight occurs through alterations in neurotransmitters, metabolic regulation, and behavioral changes. Genetic makeup can influence how individuals metabolize medications, respond to SSRIs, and manage appetite. Conversely, some individuals may experience weight loss when starting sertraline. Understanding whether sertraline leads to weight gain or loss requires a broader conversation about SSRIs in general. While it is effective for many patients, there are discussions around its side effects, especially concerning weight. Sertraline, marketed under the brand name Zoloft, is an antidepressant that belongs to a class of medications known as SSRIs. It works by increasing the amount of a natural chemical called serotonin in the brain. The funders were not involved in the design, conduct, or reporting of this study. The study conclusions do not represent an official position of the MHRA. People who do not respond to the first antidepressant can often do as well with talk therapy as they would with another drug. It often takes 6 to 8 weeks to see a response to an antidepressant. If you start taking an antidepressant, don't expect to see a major improvement right away. One antidepressant is generally as effective as another. Avoid sugary drinks, fast food, and processed snacks that can exacerbate weight gain.Additionally, lifestyle factors, such as diet and exercise habits, may also play a role in determining whether an individual experiences weight loss while taking Zoloft.People overdose on Codeine when they take more than the recommended amount of pain-relieving medication, usually because they desperately want to get rid of their pain.We truncated IPWs at the 99th percentile to reduce the influence of extreme weights.If you're struggling with depression, the most important question about taking an antidepressant is whether it will work.Even people of normal weight are at risk of becoming overweight or obese.This weight loss may occur as a result of changes in appetite or anxiety levels that can accompany the adjustment period when starting Zoloft. Some individuals might not experience any weight change, while others may find that their eating habits or preferences shift, leading to an increase in calorie intake. The medication is typically taken once daily and may take several weeks to achieve its full therapeutic effect. It works by increasing the levels of serotonin, a neurotransmitter in the brain that helps regulate mood, emotions, and behavior. It’s not the only SSRI linked with weight gain, but if that’s a concern for you, talk to your doctor about your options. What's really the healthiest diet for you? In the meantime, though, don't stop taking your medication on your own. But if that change is rapid, extreme or causing you concern, talk to your healthcare provider about your options. And kind of our goal really is to always try to balance where both mental and physical health are supported. Weight Loss in the First Few Months Compared to citalopram, the weight gain linked to other antidepressants was small. In this study, the weight gain experienced by people taking citalopram averaged one to two pounds. Earlier studies linking antidepressant use to weight gain were usually small and short. There are studies out that are saying that more than 2 diet sodas a day can make people gain weight. Always consult with a healthcare professional before making any changes to your medication regimen or dietary habits. Talk with your healthcare professional about your diet and exercise habits. Many factors can be part of weight gain during antidepressant therapy. While some people gain weight after starting an antidepressant, the antidepressant isn't always a direct cause. Some people gain weight when taking a certain antidepressant, but others don't. In general, weight gain is more likely to occur during the initial stages of treatment, often within the first few weeks or months. Your healthcare provider can help you track your progress and make any necessary adjustments to your treatment plan. If you’re concerned about weight gain or loss while taking Zoloft, it’s essential to regularly monitor your weight and body composition. Many factors may be taken into consideration when choosing the most appropriate antidepressant for a particular patient, including the effect of the drug on body weight. Finally, although analyses of weight change, treatment-emergent adverse events, and adverse events reported as the reason for discontinuation were specified in each protocol, and between-study variability was controlled for in the analyses, the decision to pool these data was not planned at the outset of this research program. The negative correlation between change in HAM-D-17 total scores and change in weight indicates that patients tended to gain weight as their depression improved. These data suggest that exposure to antidepressants is a long-term risk factor for weight gain and obesity, even after antidepressant treatment is discontinued for a long time.Antidepressants and weight gain are discussed more in another GoodRx Health article.For adjusted analyses, we calculated the NNH by applying the adjusted rate ratio to the incidence of weight gain in participants not treated with antidepressants, enabling estimation of the risk difference and its reciprocal the NNH.Variations in genes involved in collagen synthesis, thyroid hormone activity, energy metabolism, and adipocyte differentiation were implicated, suggesting that genetic profiling could predict weight gain risk and guide personalized treatment .I started a healthier lifestyle with regard to eating and also incorporated walking rapidlyRemember to consult your healthcare provider if you have concerns about weight changes or any other side effects while taking Zoloft.Mirtazapine, a noradrenergic and specific serotonergic antidepressant (NaSSA), increases neurotransmission through presynaptic alpha-2-adrenergic receptor antagonism and is known for its sedative and appetite-stimulating properties 15,21,23.More severe side effects can also occur. Cognitive therapy has been helpful in reducing weight for children and adolescents . The mean BMI (kg/m2) decreased from 29.6 kg to 25.1 kg in the posttreatment group . It is the gradual but consistent change in behavior that leads to healthier eating habits. If you’re experiencing weight loss while taking Zoloft, it’s crucial to consult with your doctor to rule out any underlying health issues that may be contributing to the weight loss. This is because Zoloft can suppress appetite, leading to a reduction in calorie intake and subsequent weight loss. Remember to consult your doctor or a healthcare professional for personalized advice and guidance throughout your treatment. By understanding the science behind Zoloft’s mechanism of action, individual factors, and potential reasons for weight loss, you can take control of your weight and overall health. The connection between Zoloft and weight loss is complex, influenced by individual factors, dosage, and duration of treatment. However, there are always methods provided by health professionals to minimize the extra pounds gained. However, once sertraline is removed from the system, excess water would also be lost. Metabolism, therefore, is certainly impacted by making consequent changes in body mass, just an accompanying effect from Zoloft discontinuation. Adjusted for age, sex, depression recording, comorbidity, coprescribing of antiepileptics or antipsychotics, deprivation, smoking, and advice on diet. Association of antidepressant prescription with increase in body mass index (BMI) category. Table 3 shows the association of antidepressant treatment with risk of increase in BMI category. Figure 2 presents adjusted rate ratios according to years of antidepressant treatment. Supplementary table 1 shows the results of a sensitivity analysis to evaluate the effect of excluding person time in which there were no weight records. Your healthcare provider will advise you if you should take sertraline while breastfeeding. Your healthcare provider will advise you if you should take sertraline while you are pregnant or trying to become pregnant. Do not stop taking sertraline without talking to your healthcare provider. Do not take sertraline unless it has been prescribed to you by a healthcare provider. This article begins with specific case studies illustrating the variability of weight changes after stopping Zoloft. For individuals new to managing medication changes, understanding the potential for weight fluctuations is crucial. It can help boost energy levels, improve mood, and contribute to a healthy weight management plan. How Can I Minimize Weight Gain While Taking Zoloft? But side effects are still possible, and it’s helpful to know what to expect and how to manage them if they happen. Sertraline works well and has fewer side effects than some other SSRIs. Serotonin is a chemical messenger that’s involved in multiple processes in the body. SSRIs work by raising the amount of serotonin in the brain. I believe that stepping away from the screen to explore new cultures and environments is essential for mental clarity and fresh perspectives. The exact mechanism behind the weight gain caused by Zoloft is not fully understood. Why does Zoloft cause weight gain? They can evaluate your individual situation and provide guidance on managing your weight effectively while on the medication. Work with a registered dietitian or nutritionist to create a meal plan that supports your weight-management goals. Consult with your healthcare provider before starting any new exercise regimen. The relationship between Zoloft and weight changes is intricate and highly individual. Further research is needed to fully understand the complex interplay between SSRIs, weight regulation, and individual genetic predispositions, paving the way for more targeted and effective therapies in the future. Several factors influence the likelihood and extent of weight change, which we will explore in subsequent sections. Both the recommended starting dosage and therapeutic range in patients with mild hepatic impairment (Child Pugh scores 5 or 6) are half the recommended daily dosage see Dosage In Patients With MDD, OCD, PD, PTSD, And SAD, Dosage In Patients With PMDD. For adults and pediatric patients, subsequent dosages may be increased in case of an inadequate response in 25 to 50 mg per day increments once a week, depending on tolerability, up to a maximum of 200 mg per day. The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below. Each mL of solution contains 22.4 mg sertraline hydrochloride equivalent to 20 mg of sertraline. Zoloft use during pregnancy may lead to adverse effects in the newborn. If there is a concern about the health of your liver, your healthcare provider may do tests to determine if it is working well enough to take this medicine. Tell your healthcare provider if you have any of the following sexual problems. Taking sertraline or another selective serotonin reuptake inhibitor (SSRI) may cause sexual problems. Zoloft, also known as sertraline, is an antidepressant medication that belongs to the selective serotonin reuptake inhibitors (SSRIs) class. The effects of sertraline on weight in patients with major depressive disorder. Remember to consult your healthcare provider if you have concerns about weight changes or any other side effects while taking Zoloft. Another study published in 2014 reported that Zoloft was linked to weight gain in a sample of 130 patients with major depressive disorder (2). Other SSRIs and Weight Gain Those who are overweight can benefit most from activities, such as bicycling and running. This should include a diet of vegetables, fruit, and whole grains. Overweight individuals who take this drug are less likely to develop heart disease, sleep apnea, and type 2 diabetes. Those who are underweight are prone to other problems, such as reduced fertility and irregular menstrual cycles. Those who gain weight while taking this drug are typically prone to binge eating or are preoccupied with food. There was no effect on male and female reproductive endpoints or neurobehavioral development up to the highest dose tested (80 mg/kg/day), except a decrease in auditory startle response in females at 40 and 80 mg/kg/day at the end of treatment but not at the end of the drug-free period. A study conducted in juvenile rats at clinically relevant doses showed delay in sexual maturation, but there was no effect on fertility in either males or females. Two placebo-controlled trials were conducted in pediatric patients with MDD, but the data were not sufficient to support an indication for use in pediatric patients. Safety and effectiveness have not been established in pediatric patients for indications other than OCD. Safety and effectiveness in pediatric patients in patients with OCD below the age of 6 have not been established. Once Zoloft begins to take effect and stabilizes their mood, individuals may regain a healthier eating pattern, which can lead to weight loss as they return to a normal appetite. Over time, the body may adjust, and appetite changes could stabilize, leading to different weight outcomes. Zoloft, known generically as sertraline, is one of the most commonly prescribed medications for depression and anxiety disorders. It’s crucial to discuss any concerns or changes in weight, appetite, or metabolism with a healthcare provider. It acknowledges the importance of a balanced approach that incorporates physical health into mental health treatment, aiming to empower individuals with the knowledge and tools they need to make informed decisions about their care. This side effect, although not universal, has been a point of concern for patients and healthcare providers alike, necessitating a deeper understanding and effective management strategies. Hopefully, what you’ve learned here can help make you’re coming off sertraline weight loss journey a little easier. In general, some antidepressants seem more likely to cause weight gain than do others. If you find an antidepressant that works well for you, sticking with that treatment and trying some weight loss strategies may be the best path to take.” It could be the antidepressants, increased appetite as depression lifts, or something else. Both classes can cause weight gain, but they differ in that atypical antipsychotics cause fewer movement disorder side effects. However, long-term use (longer than a year) can cause downregulation of serotonin receptors, which subsequently causes cravings for carbohydrate-rich foods such as bread, pasta, and sweets that ultimately may lead to weight gain. All of these medications increase serotonin levels in the brain. In fact, many of them reduce appetite and can cause weight loss as a side effect. “Unexplained weight loss may signal an underlying health issue that needs to be assessed,” says Dr. Maline. Ask for a revised dose or alternative medication. Exercise can also help you feel better as it promotes the release of dopamine and serotonin. Exercise ensures that you burn the calories that you consume, leaving nothing deposited as body fat. The clinical significance of this apparent gender effect is unknown at this time. Post hoc exploratory analyses revealed a statistically significant difference between ZOLOFT and placebo on the CAPS, IES and CGI in women, regardless of baseline diagnosis of comorbid major depressive disorder, but essentially no effect in the relatively smaller number of men in these studies. As PTSD is a more common disorder in women than men, the majority (76%) of patients in Studies PSTD-1 and PSTD-2 described above were women. Not only is your depression or anxiety likely to get worse, you may also feel nauseous and like you have the flu. Keep in mind that stopping sertraline without a plan in place is usually not a good idea. Sertraline belongs to selective serotonin reuptake inhibitors (SSRI). Metabolic Changes For the approximately 40% of prescriptions missing data on duration, we conservatively assumed a 1-month prescription, the shortest possible time. At the same time, we likely underestimated adherence because of limitations of the data. We also examined 12- and 24-month weight change, but the results were limited by low adherence. There is variability among the drugs effective in the treatment of MDD in the extent of clinically important 2D6 inhibition, and in fact ZOLOFT at lower doses has a less prominent inhibitory effect on 2D6 than some others in the class. The extent to which this interaction is an important clinical problem depends on the extent of the inhibition of CYP2D6 by the antidepressant and the therapeutic index of the co-administered drug. The drugs for which this potential interaction is of greatest concern are those metabolized primarily by CYP2D6 and that have a narrow therapeutic index (e.g., tricyclic antidepressant drugs and the Type 1C antiarrhythmics propafenone and flecainide). Is the weight finally lost, many months or even years after the antidepressants or related drugs are out of the body? So if weight gain is caused by the medication, then weight loss should follow its discontinuation. But people whose obesity is a side effect of their medication may never have had a problem maintaining a normal weight prior to their treatment. Side effects from medications are common, although usually not severe enough to halt treatment. Consider signing up for community-based weight management programs specially designed for patients taking meds to treat various mental health disorders. Sertraline can cause serotonin syndrome when it is taken alone or with other medicines that affect serotonin. In the U.S., you can report side effects to the FDA at /medwatch or by calling 800-FDA-1088. It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C), for shorter periods of time, such as when transporting it. Sertraline is available as Zoloft and generic sertraline in the following dosage forms that are taken by mouth. Many antidepressant drugs (e.g., SSRIs, including ZOLOFT, and most tricyclic antidepressant drugs) inhibit the biochemical activity of the drug metabolizing isozyme CYP2D6 (debrisoquin hydroxylase), and, thus, may increase the plasma concentrations of co-administered drugs that are metabolized by CYP2D6. Thus sertraline multiple dose pharmacokinetics appear to be unaffected by renal impairment see Use In Specific Populations. Steady-state, therefore, was achieved after 2 to 3 weeks in older patients. They can provide tailored advice and support to help you manage both your mental health and your physical well-being. While some adults may experience weight loss as a side effect of taking Zoloft, others may not see any changes or may gain weight. These factors highlight the importance of closely monitoring your symptoms and discussing concerns with a healthcare provider. If you experience significant weight changes, your doctor can evaluate your treatment plan and make necessary adjustments. Regular follow-up appointments can help track your weight and overall health. In Understanding Depression, find out how effective treatment can lighten your mood, strengthen your connections with loved ones, allow you to find satisfaction in interests and hobbies, and make you feel more like yourself again. "We know that certain kinds of talk therapies, especially cognitive behavioral therapy, can be very effective for treating depression and anxiety disorders," Dr. Perlis says. "The best way to manage side effects is to anticipate them — to have an open conversation with your doctor about the potential risks and how we'll manage them if they occur," Dr. Perlis says. "As with any study that's not randomized, we don't know if the differences between medicines could reflect other differences in who gets prescribed these medicines," Dr. Perlis says. Studies suggest that 50% or more of patients who take SSRIs like Zoloft experience sexual problems. These include sexual dysfunction, weight changes, menstrual changes, nipple discharge, and bone loss. However, certain side effects only affect women or have different risks in women. Both men and women can experience side effects from Zoloft. It is a type of selective serotonin reuptake inhibitor (SSRI). This study found differences in medication-induced weight gain over 6 months both within and between antidepressant subclasses. Few patients were prescribed stimulants, steroids, or weight loss medications over follow-up (Supplement Table 4, available at Annals.org). The percentage of patients with a weight measurement exactly at the 6-, 12-, and 24-month time points ranged from 15% to 30% across medications; 40% to 50% had a weight measurement at 1 or more time points. Across treatments and time points, 5% to 13% of patients who stopped adhering to the treatment protocol switched medications within 3 months, and 7% to 10% of those who were adherent added an additional medication. The median time that patients adhered to the medication treatment, according to our criteria, was 4 months for sertraline, citalopram, escitalopram, fluoxetine, bupropion, and venlafaxine and 3 months for paroxetine and duloxetine. In this case, if an individual experiences an increase in the mass at a lower dose, the increased dosage can double the body size and lead to sertraline HCL high. A higher dosage means that people give the medication more control over their nervous system than the innate homeostatic functioning. It is now well-recognized that prolonged use of antidepressants can cause mass changes. Many commonly used antidepressants can lead to insulin resistance (IR) in individuals with and without type 2 diabetes mellitus (T2DM) 92,93. Antidepressant use has been linked to changes in insulin resistance, with various antidepressants, including SSRIsm TCAs, and mirtazapine, implicated in the development of these metabolic disorders . TCAs inhibit H1 histamine and muscarinic acetylcholine receptors, both of which have been linked to increased food intake and weight gain . Less common or rare Calls to any general helpline listed on this site may be answered or returned by a paid advertiser that is a licensed treatment provider. Addiction Resource does not offer medical diagnosis, treatment, or advice. Aerobic exercises are the best-suitable technique that can help to lose weight being on the Zoloft post discontinuation period. Advise patients that use of ZOLOFT may cause symptoms of sexual dysfunction in both male and female patients. Inform patients not to take disulfiram when taking ZOLOFT oral solution. It is important for prescribers to inquire about sexual function prior to initiation of ZOLOFT and to inquire specifically about changes in sexual function during treatment, because sexual function may not be spontaneously reported. Finally, environmental and socioeconomic factors can influence eating habits, physical activity levels, and overall lifestyle, impacting weight management while on Zoloft. Increased social interactions, changes in physical activity levels, and alterations in diet can all influence weight. Additionally, the regained interest in life and activities can lead to social eating and other lifestyle changes that contribute to weight gain. The study was observational, meaning it cannot prove that antidepressants cause weight changes, only that they were linked with them. "One caution is that some people lose weight as a result of depression, which can impact appetite," he adds, "so some of what we're seeing may be people regaining weight they'd lost as their depression or anxiety improves." Many people taking antidepressants won't gain any weight and others could gain more. Health care providers generally ask people who are taking lithium to participate in regular monitoring to check lithium levels and kidney and thyroid function.“That could mean an upset stomach, nausea, or changes in bowel habits like constipation or diarrhea.” Dr. Murrough suggests starting on the lowest possible dose to avoid these issues, then increasing the dosage as your system acclimates to the extra serotonin.Again, too, talk to your healthcare provider if you experience rapid or significant weight gain.It belongs to a group of antidepressants called selective serotonin reuptake inhibitors (SSRIs).The likelihood of weight changes varies depending on the specific medication and individual factors, such as starting weight, diet, and exercise habits.Several antidepressants are less likely to cause weight gain than sertraline.Other side effects not listed may also occur in some patients. This can lead to consuming more calories than usual, resulting in weight gain. This increase in serotonin helps to regulate mood, appetite, and sleep patterns. Zoloft is a selective serotonin reuptake inhibitor (SSRI), a type of antidepressant that works by increasing the levels of serotonin in the brain. Applying our inclusion/exclusion criteria, we identified 5932 patients who initiated 6186 monotherapy antidepressant treatment episodes during the study period. During the years of our study the second-generation antidepressant medications ecitalopram, fluvoxamine, and nefazodone were not on the Group Health formulary. Demographic and enrollment information, weight and height, prescription medication use, health care encounters, and medical conditions were extracted from GH electronic health care databases for all years of our study. Compounded medications do NOT undergo pre-market review or an FDA-approval process. Weight gain can affect self-esteem, body image, and overall mental well-being. Pediatric patients require tailored care and frequent assessment to manage potential side effects effectively. The choice of medication should be based on a comprehensive evaluation of its effectiveness for your condition and potential side effects. Zoloft is a type of antidepressant called selective serotonin reuptake inhibitor (SSRI). For many, as the medication might be helping their quality of life substantially, but they also get very upset when they’re continuing to gain weight. 5.) Are there ways to counter any weight issues from Zoloft without getting off the medication? As a rule, weight changes are based more on individual body physiology rather than gender. Now add in the effects of anti-depressants like Zoloft and your body might not be able to tell where it’s “equilibrium” is anymore.? Nine of the 13 subjects suffered from major depressive disorder and were taking serotonergic antidepressants. Patients must take other medications one hour before or after orlistat to avoid change in absorption . Patients take orlistat 120 mg three times daily and must take a multivitamin to avoid deficiencies and eat a low-fat diet. That said, untreated mental health conditions during pregnancy may also pose health risks for newborns. “In my practice, I often remind patients that untreated depression and anxiety can also negatively impact sex drive.” A small percentage of patients report a decrease in appetite. Although not common, weight gain from long-term Zoloft use may contribute to a person’s risk of diabetes. Viatris Inc. understands that your personal and health information are private. To keep up with the latest from ZOLOFT® (sertraline HCl), enter your information below. ZOLOFT and other medicines may affect each other causing possible serious side effects. It then progresses to a more general discussion of potential mechanisms, managing weight changes, and considerations for different audiences. As with any condition, there are numerous alternative treatment plans available for depression and other mental health conditions Zoloft was approved to treat. In fact, Wellbutrin is one of the least likely antidepressants to cause weight gain. It’s also less likely to cause sexual problems, sleepiness, and weight gain compared to some other antidepressants. For individuals with increased susceptibility to metabolic complications, medications including bupropion, fluoxetine, and newer agents (e.g., gepirone) have shown to be efficacious in improving depressive symptoms while concurrently reducing metabolic risks. We addressed this with IPWs that adjusted for demographics, health behaviors, diagnoses, and prescriptions that predict having a weight measurement, as also recommended for RCTs with incomplete outcome ascertainment (45). First, time-varying confounding by new diagnoses, prescriptions, or health behaviors that predict adherence was likely present. Third, we did not have consistent information on medication dose and could not examine dose–response effects. It’s important to prioritize mental wellness while addressing any physical health concerns, ensuring a safe and effective transition. Stopping Zoloft abruptly can lead to withdrawal symptoms and a potential worsening of the underlying mental health condition being treated. It’s essential to communicate openly about any concerns regarding weight changes, as well as any other side effects you may be experiencing. They can evaluate your overall health, review your lifestyle habits, and consider the necessity of medication adjustments. Keeping a food journal or seeking advice from a nutritionist may also aid in maintaining a balanced diet, while a fitness plan can encourage weight management. Healthy Eating Finally, she was placed on an MAOi (tranylcypromine) with partial symptom improvement, but also a 15–20 kg weight gain. Clozapine may ultimately be the most likely agent to cause weight gain of all psychotropics producing increases of 2.4 to 31.3 kg, which is often a 10 percent gain over baseline 35–39. Quetiapine (regular release and extended release) also has been implicated in causing a more remarkable weight gain of 4.1 to 5.6 kg 33, 34. With the introduction of the newer, atypical second generation antipsychotics (SGAs), the potential to cause remarkable weight gain has been recognized. The above case is a typical and common example of iatrogenically induced weight gain. Six months after initiation, we estimated that approximately 1 in 3 patients was still adherent to their initially prescribed medication. For example, 6-month weight change was lower for bupropion versus sertraline (difference, −0.80 kg CI, −1.26 to −0.42 kg) and higher for escitalopram versus sertraline (difference, 1.03 kg CI, 0.52 to 1.45 kg) than in ITT analyses. Associations were generally stronger across time points in per protocol analyses, which accounted for medication adherence (Table 5; Supplement Figure 2 and Supplement Table 5, available at Annals.org). Mean weight change was estimated from models adjusting for time and baseline covariates. The curves begin at month 1 because the model estimates effects on weight change only after baseline. Monitoring physical changes over time helps create comprehensive plans for maintaining mental and physical health. Healthcare teams at places like OC Revive provide support for balancing effective treatment of depression with strategies for maintaining physical health. Behavioral therapy combined with dietary education can lead to better outcomes for managing unwanted pounds during treatment for depression. Centers for Disease Control and Prevention guidelines also recommend reducing processed foods to improve physical health outcomes during antidepressant treatment. If one believes their current efforts to lose weight should be more productive, a consultation with a nutritionist may be helpful. Losing weight is often a struggle, especially when a person is also living with a mood disorder. Fay Nutrition has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. If you are worried about managing your weight on Zoloft, consider personalized guidance from an expert Registered Dietitian Nutritionist. Weight gain is highly personal, and there may be many reasons why you gain weight. Wellbutrin (bupropion) is an antidepressant that’s least likely to cause weight gain. It’s more likely to cause weight loss with short-term use, but can lead to weight gain with long-term use. Paxil (paroxetine) is a selective serotonin reuptake inhibitor (SSRI) that’s connected to weight gain both short-term and long-term. Remeron (mirtazapine) is another antidepressant that’s more likely to cause weight gain. Depression treatment may involve psychotherapy or medications. Sertraline side effects: On the other hand, an increase in weight is an expected side effect of the medication. It is one of the expected side effects of the medication that can occur in individuals; however, not everyone experiences it. Experts believe you can gain 10 pounds in a year; however, weight gain varies from individual to individual. It is one of the expected side effects of the medication. However, the weight gain is modest (10 pounds or more). ZOLOFT should be prescribed with caution in patients with a seizure disorder. Patients with a history of seizures were excluded from clinical studies. ZOLOFT has not been systematically evaluated in patients with seizure disorders. In controlled clinical trials, patients with bipolar disorder were generally excluded; however, symptoms of mania or hypomania were reported in 0.4% of patients treated with ZOLOFT. For patients taking warfarin, carefully monitor the international normalized ratio. In some cases, children continued to lose weight. Some adults reported losing more significant amounts of weight, but that is a rare situation. Reach your goals and continue to set new ones for a happier, healthier you! However, it’s essential to remember that each individual’s reaction to the medication can differ significantly. Finding enjoyable activities, whether it’s walking, jogging, yoga, or swimming, can help individuals maintain a healthy lifestyle while they are on Zoloft. For example, bupropion (Wellbutrin) and nortriptyline (Pamelor) are antidepressants that have been shown to have a lower risk of weight gain. While many antidepressants can cause weight gain, some may be less likely to do so. However, if you are experiencing anxiety or depression, it is essential to prioritize your mental health and treatment. Additionally, talk to your doctor about any concerns you may have about weight gain, and explore alternative medications or dosage adjustments if necessary. Eat a healthy and balanced diet, engage in regular exercise, and stay hydrated to reduce the risk of weight gain. Zoloft can also affect metabolism, which can contribute to weight loss in some individuals.Weight loss is a common goal for many individuals, but for those taking Zoloft, a popular antidepressant medication, achieving this goal can be a significant challenge.Below, we’ve discussed the relationship between sertraline and weight gain, as well as what you can expect if you’ve been prescribed this antidepressant medication.However, there may be side effects to manage.One of the primary reasons why people may experience weight gain or loss while taking Zoloft is due to its effect on appetite.Considering the entire period of follow-up (10 years), participants who were prescribed an antidepressant had an increased risk of ≥5% weight gain compared with those who had never been prescribed an antidepressant, after allowing for differences in case mix.Second, in our PP analysis, we have a very small number of people actually completing the two years of treatment. It’s essential to consult with your doctor before taking any new medications, including weight loss medications, especially if you’re stopping sertraline. Stopping sertraline may help reduce weight gain caused by the medication, but it’s not a magic bullet for weight loss. Yes, even if you stop taking sertraline, it’s still essential to maintain a healthy diet and regular exercise routine to achieve and maintain weight loss. With a healthy diet and regular exercise, you can work towards your weight loss goals and maintain weight loss over time. They may be able to adjust your dosage, switch you to a different medication, or provide guidance on managing weight gain while still treating your mental health condition. The exact mechanisms are not fully understood, but it’s believed that sertraline influences the brain’s reward system, increasing cravings for comfort foods and carbohydrates. A doctor should be consulted to develop a tapering schedule to safely discontinue the medication. It’s also important to note that stopping sertraline abruptly is not recommended, as this can lead to withdrawal symptoms. Always talk to your GP about the risks and benefits of any treatment. It’s used by millions of people in the United States and internationally, with a good record of safety and effectiveness. Identifying a safer alternative treatment or seeking treatment for safe and proper antidepressant withdrawal are two extremely important steps on your own recovery journey. Improperly managed withdrawal after long-term Zoloft use can keep a person locked in a vicious cycle of lingering Zoloft side effects and discontinuation syndrome for a very long time.5 These offer a safer, more holistic option for addressing your mental health. For this reason, it is critical to consult with a healthcare provider who has familiarity with the subject to gradually taper your use of Zoloft to zero. As with any new prescriptions, potential interactions with your current medications are a known potential risk. Anti-anxiety medications help reduce symptoms of anxiety, such as panic attacks and extreme fear and worry. It is important for health care providers to consider all possible interactions and use extra care in prescribing and monitoring medication combinations that have an above-average risk. The side effects are generally mild and tend to go away with time. The studies really have shown minimal to no weight gain with our antidepressant medications that we've seen. The study, published Monday in the journal Annals of Internal Medicine, used electronic health record prescription and body mass to compare weight gain among more than 183,000 people. In addition to maintaining a healthy diet and exercise routine, there are several strategies for managing weight gain caused by antidepressants. However, studies show cases where medical marijuana use can interact with conventional medications like the SSRI Zoloft, and many others. Tapering off sertraline slowly allows your body to adjust to the decrease in medication and reduces the likelihood of withdrawal symptoms. The amount of time it takes to lose weight after stopping sertraline varies greatly from person to person. This involves gradually reducing the dosage of sertraline over a period of weeks or months to give your body time to adjust. Patients who have become obese due to their medication believe their bodies will be permanently changed. Formerly fit individuals are horrified to find that the 15, 25, or 50 pounds they gained on their medication is hanging around like a relative who won’t quit the guest room. Increasing serotonin levels and activity prior to meals diminishes any lingering inability to feel full after eating or to control snacking. Antidepressant medications are the first-line treatment option for moderate to severe major depressive disorder. Side effects include skin rash, constipation, upset stomach, loss of appetite,headache,diarrhea, abnormal ejaculation decreased interest in sexual activity, anddry mouth.Drug interactions, dosage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication. Sertraline(Zoloft) is a medication prescribed for the treatment of depression, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD). Therefore, patients should not receive treatment with both pimozide and sertraline. All SSRIs, including sertraline, should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants, for example GH guidelines emphasize cognitive-behavioral therapy as part of first-line therapy for depressive disorders; however, antidepressant drug treatment surpasses psychotherapy as the initial treatment of choice for depression at GH, and 75% of antidepressant therapy is prescribed by Primary Care Physicians (PCPs).What's really the healthiest diet for you?But if you experience unwanted weight gain while taking an antidepressant, don’t stop taking your antidepressant on your own.The most important aspect is to prioritize your mental health and work closely with your healthcare provider to find the best treatment plan for your individual needs.Individuals who are taking Zoloft may have questions about the medication’s impact on weight loss or gain.The above case is a typical and common example of iatrogenically induced weight gain.Overall, these studies demonstrated ZOLOFT to be superior to placebo on the Hamilton Rating Scale for Depression (HAMD-17) and the Clinical Global Impression Severity (CGI-S) of Illness and Global Improvement (CGI-I) scores.And coming off sertraline feel awful also. Regular Tae Bo practice can improve cardiovascular health by increasing heart rate, reducing blood pressure, and enhancing overall cardiovascular function. Tae Bo is an intense workout that can burn a significant number of calories, making it an effective way to create a calorie deficit and lose weight. Regular aerobic exercise, such as Tae Bo, can improve insulin sensitivity, allowing your body to more efficiently use insulin and regulate blood sugar levels. Sometimes clinicians can “chase their tails” by adding anti-side-effect medications to a patient's regimen. A large, phase 3 clinical trial has shown that one year of treatment with this combination led to weight loss of up to 9% beyond that seen with placebo therapy. Several clinicians have noted that the combination of phentermine and topiramate can generate substantial weight loss in at least a subset of patients who exhibit little weight loss when treated with phentermine alone. Because of the distinct mechanism of action of these two medications, naltrexone-bupropion may prove to be an attractive option for patients who are resistant to other agents. A review of 40 total medical records from 3 sites found that 85% of patients meeting this criterion were indeed new users (Supplement Methods, available at Annals.org).Keep sertraline out of the reach of children.Side effects from medications are common, although usually not severe enough to halt treatment.Major depressive disorder (MDD) is a serious public health problem.Maintaining a balanced diet that includes a variety of fruits, vegetables, and whole grains can help mitigate any unwanted weight changes.I joined a gym at the end of october and was working out 4-5 days a week for 2 hours and also watching my diet.No, do not stop taking Zoloft on your own if you experience weight loss symptoms.Weight gain is among the most common complaints in those who are prescribed medications to treat depression.Sertraline is available as Zoloft and generic sertraline in the following dosage forms that are taken by mouth.Some patients report mild weight gain after beginning treatment for depressive symptoms, anxiety disorders, or obsessive-compulsive disorder. People overdose on Codeine when they take more than the recommended amount of pain-relieving medication, usually because they desperately want to get rid of their pain. If used recreationally, Ketamine can be dangerous, causing long-term side effects such as high blood pressure, impaired memory, impaired motor function, and fatal breathing issues. These pills that are dangerous can also cause respiratory depression, like breathing and heart rate, increasing the risk of death. Around 25% of people with chronic pain are prescribed Oxycodone, and 5-10% of those also suffer from addiction to the drug. Some of the negative side effects from increased dosages include slowed heart rate, increased risk of liver and kidney disease, impaired motor function, and more. The first instinct that most people have when trying to lose weight is to skip a meal. Trying to lose weight at the same time might seem impossible. Dealing with any mental health illness is daunting in itself. So, one way or another, SSRIs cause weight gain. Weight gain appears to be more likely when taking higher doses or for people taking the antidepressant drug for extended periods. Some research also suggests that other types of antidepressants might have a higher risk than Zoloft. Get access to therapy, medication management, and personalized treatment The reasons for these discrepancies involve factors such as dosage, treatment duration, and individual patient differences. Zoloft works by increasing the levels of serotonin, a neurotransmitter in the brain, which plays a crucial role in regulating mood and emotion. It is primarily prescribed to treat conditions such as depression, anxiety disorders, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD). Emphasize a balanced diet that includes fruits, vegetables, whole grains, and lean protein sources. Other medications, such as phentermine or orlistat, are specifically approved for weight loss, but they may have different side effect profiles and contraindications. Certain antidepressants, such as bupropion (Wellbutrin), may be more effective for weight loss in some individuals. However, it’s essential to consult with a healthcare provider before switching medications or adding new ones. While Zoloft is not typically prescribed for weight loss, there are alternative medications that may be more effective for weight management. But weight loss after stopping antidepressants is not that easy. Sometimes people are so fearful once they start gaining weight, they might stop taking their medication. So, it seems that antidepressants cause weight gain after all. But the bad news is that almost all antidepressants are related to some degree of weight gain. The results vary from individual to individual, and it depends on the duration of the treatment. Sertraline acts by increasing the amount of serotonin (the happy hormone or chemical) in the brain. Sertraline is a prescription medication sold under the brand name Zoloft. The zoloft I also starting to have a weird effect; I don't want to do anything any more. I never thought it had anything to do with the zoloft. The incidences of PCS weight gain (≥?7%) from baseline to endpoint or at any time were not significantly different for duloxetine-treated compared with placebo-treated patients. When 1 study (long-term placebo-controlled dataset) or 2 studies conducted under a common protocol (acute fluoxetine-controlled and long-term placebo- and paroxetine-controlled datasets) were analyzed, the ANOVA model included the categorical effects of treatment and investigator. In addition to the actual weight data, treatment-emergent weight-related adverse events (appetite decreased, appetite increased, and anorexia) were collected in all the studies. Data from acute and long-term treatment clinical studies were therefore analyzed to evaluate whether duloxetine has an effect on weight in patients with MDD. She was placed on the second generation antipsychotic, quetiapine, with moderate symptom reduction but began to gain weight (3–5 kg) and asked for other treatment options. After a more remarkable weight gain was noted with the second generation antipsychotic, she was offered off-label use of chromium picolinate, or metformin, or approved use of orlistat. Early intervention is the key to preventing significant drug-related weight gain. Psychotropics with greater ability to block H-1 receptors often show greater weight gain potential , possibly through deactivating brain satiety centers. Many of the antipsychotics (olanzapine, quetiapine, and clozapine) and some antidepressants (mirtazapine) have this 5-HT2C blocking property. This weight loss is thought to be due to the medication’s effects on appetite and metabolism. It’s essential to remember that Zoloft is a medication primarily used to treat mental health conditions, not a weight loss aid. Discuss your weight loss goals with your healthcare provider or a registered dietitian to create a personalized plan tailored to your needs. We are also exploring new methods to prevent and treat depression and improve the delivery of care for people living with depression. Information about the prevalence and treatment of depression in the United States. Digital brochures and fact sheets with more information about depression, including signs, symptoms, and treatment options. This comparison is critical for patients looking for alternatives based on weight considerations. The longer a person takes sertraline, the more likely they may experience weight changes. A person’s lifestyle choices can significantly influence weight while taking sertraline. Variations in specific genes may determine how someone responds to sertraline, affecting weight management. Research indicates that over a substantial duration, the risk of weight gain can increase, making it essential for users to monitor their weight. In a study of radiolabeled sertraline involving two healthy male subjects, sertraline accounted for less than 5% of the plasma radioactivity. Linear doseproportional pharmacokinetics were demonstrated in a single dose study in which the Cmax and area under the plasma concentration time curve (AUC) of sertraline were proportional to dose over a range of 50 to 200 mg. The effect of sertraline on the QTc interval was evaluated in a randomized, double-blind, placebo- and positive-controlled three-period crossover thorough QTc study in 54 healthy adult subjects. The highest dose of 80 mg/kg/day produced plasma levels (AUC) of sertraline 5 times those seen in pediatric patients (6-17 years of age) receiving the maximum recommended dose of sertraline (200 mg/day). Fluvoxamine and Viibryd (vilazodone) aren’t likely to affect your weight with short or long-term use.NIMH has information on ways to get help and find a health care provider or access treatment.However, we required at least 6 months of lead time before initiation, and our findings were similar when requiring at least 12 months of lead time.Weight gain is one of the more common side effects reported by users of Zoloft.Sertraline may cause a serious condition called serotonin syndrome if taken together with some medicines.The study, published Monday in the journal Annals of Internal Medicine, used electronic health record prescription and body mass to compare weight gain among more than 183,000 people.A 2024 study shows that increases are typically minor, averaging about 3 pounds within two years of starting a medication.Sometimes these side effects continue even after someone stops taking these medicines.Along with its needed effects, a medicine may cause some unwanted effects. In the underworld, fentanyl is often added to other substances without the buyer's knowledge, to increase the potency and pleasurable effects of other drugs. Fentanyl is a synthetic opioid known to be so potent that it is 100 times stronger than morphine. In 2020, an average of 44 people died each day from overdoses related to prescription opioids in the US, which is more than 16,000 in 2020 alone! But, the reality is that there are many dangerous prescription drugs that people overdose from when taken in large amounts or mixed with other substances. “But I’ve talked with patients who have gained significantly more weight on antidepressant medication, too,” Dr. Maline notes. In a 12-week open label study conducted on 19 patients (aged 10–18 years) who had gained over 10% of their baseline weight while on antipsychotics, 500 mg three times a day of metformin was given for 12 weeks in addition to psychotropics. In another study, naltrexone was coadministered with antidepressants to eight female patients who had already gained more than 6 kg. The average weight loss within this relatively short time period was 5.6 kg or 34.6% of the weight gained as a result of psychotropic drug use.