The Massachusetts Male Aging Study is one of the best epidemiological studies ever done and it is ongoing, with some additional data from it published only recently (1). Most of them are similar to the drugs reviewed in this article in that they stimulate the corpus cavernosum or the central nervous system (CNS). Essential Homme Magazine enlists models Dylan Moran and Erik van Gils to star in Volition story captured for their latest edition by fashion photographer Byron Mollinedo. Ryan enjoys teaching, reading, writing, and sharing history with anyone who will listen. Similar articles While this agent is not designed for treatment of ED, its combined central and peripheral activity does improve erectile function in men with mild ED. However, the adrenoreceptors in the penile erectile tissue are primarily alpha-1 type (16). Similarly, the mechanism of erection and its dependence upon neurogenic, arterial, venous, and androgenic systems to produce erectile rigidity continues to be elucidated. Clearly, then, normal nitric oxide production requires adequate levels of testosterone. Early agents such as trazodone, yohimbine, and delaquamine that depend on alpha blockade appear to demonstrate clinical effectiveness in generating erectile function (17).NO indicates nitric oxide; NANC, nonadrenergic-noncholinergic neurons; GTP, guanosine triphosphate; GMP, guanosine monophosphate; cGMP, cyclic guanosine monophosphate; and PDE5, phosphodiesterase type 5.Essential Homme Magazine enlists models Dylan Moran and Erik van Gils to star in Volition story captured for their latest edition by fashion photographer Byron Mollinedo.Now we know that about 60% of patients have organic ED, which we define as a vasculogenic, neurologic, hormonal, or smooth muscle abnormality;In 1885, at the height of his career, Moran began on what would be considered his most important work - a series of 13 paintings representing the Marine History of the United States.In one scene, Batman/Bruce Wayne (Christian Bale) attacks a convoy from the air, and the “tanks” tasked with protecting a truck within the line use cannons and missiles to fire back.Most of them are similar to the drugs reviewed in this article in that they stimulate the corpus cavernosum or the central nervous system (CNS). When a healthy man receives psychological or physical stimulation of the penis, first nitric oxide is released from the nerve endings in the corpus cavernosum, which produces dilation of the cavernosal arteries. In this article, I review the physiology of erections and the new medications available to treat erectile dysfunction (ED). BIOGRAPHY'Moran left England for America at a very early age, and began his art studies in Philadelphia. Upon returning home, Moran’s paintings reflected Turner’s sense of drama with brilliant skies and turbulent green seas. In 1861 Edward and his brother, Thomas, continued their artistic education with a trip abroad. Although born in England in 1829, Edward Moran was one of the most prestigious American historical and marine painters of his generation. He starts up, and to everyone’s surprise, it’s a smoke show! Efficacy of sildenafil citrate (Viagra) in improving erections.Sildenafil is also safe and effective in patients taking a variety of other medications.The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy.Similarly, the Treatment of Mild Hypertension Study has documented the improvement in erectile function in men with mild hypertension compared with placebo (31).In the 1850s Moran began to make a name for himself in the Philadelphia artistic scene; working in the same studio as his younger brother, famous American painter Thomas Moran, Edward received commissions and even completed some lithographic work.The paintings were widely exhibited before being given to the New York Public Library.The erection persists until the stimulation is decreased and the nitric oxide disappears. In one scene from the 2022 adaptation of All Quiet on the Western Front, French Saint-Chamonds approach German trenches. The German armor shown in the scene includes a Marder, a Sturmgeschütz (StuG) and a Jagdpanther. The authenticity of this scene is evident in even the smallest details. She received her BFA from NYU’s Tisch School of the Arts in the Department of Photography + Imaging in New York. It’s a nuanced capture of spaces that are often banal and ordinary that set the stage for individual titillation and engagement once the cameras start rolling. Additional Edward Moran Paintings Previously Sold It was in Philadelphia around 1845 that Edward apprenticed under James Hamilton and landscape painter Paul Weber; Hamilton guided Moran specifically in the style of marine paintings. He is arguably most famous for his series of 13 historical paintings of United States marine history. We have included a “Date Added” field to flag new titles to this list. Therefore, the above list is more current and reflects titles that have been added after August 15, 2025. If the testosterone level is abnormal, it should be repeated with a morning level. While we know that ED increases as patients age, diabetes pushes that age curve to the left. The researchers compared representatives from each of the most commonly used families of drugs with placebo and followed the subjects for 2 years, asking questions related to lifestyle as well as the control of hypertension. It is also important to determine what medications patients are taking (Table). The first twenty-seven years of his artistic career were spent in Philadelphia, where he studied painting with the marine painter James Hamilton and with the landscapist Paul Weber. During the last decade of his career, Moran dedicated himself to 13 paintings depicting epochs in U.S. marine history. Fine nineteenth through twenty-first century American and European paintings, with an emphasis on Maine and Monhegan Island artists One of his more well-known exhibits, titled Land and Sea, showed 75 of his landscape and marine paintings in March 1871; these paintings were later illustrated in a catalogue by the same name. In the 1850s Moran began to make a name for himself in the Philadelphia artistic scene; working in the same studio as his younger brother, famous American painter Thomas Moran, Edward received commissions and even completed some lithographic work. Depression affects erectile function to a similar degree.Early agents such as yohimbine, often considered an aphrodisiac in men, produces its effect on erectile function by blocking alpha-2 adrenergic receptors (14, 15).The researchers compared representatives from each of the most commonly used families of drugs with placebo and followed the subjects for 2 years, asking questions related to lifestyle as well as the control of hypertension.Ryan enjoys teaching, reading, writing, and sharing history with anyone who will listen.In one scene from the 2022 adaptation of All Quiet on the Western Front, French Saint-Chamonds approach German trenches.Fine nineteenth through twenty-first century American and European paintings, with an emphasis on Maine and Monhegan Island artistsIf your chapter uses OpenWater for Thespy registration, titles are pre-populated from the above list. Cited by other articles This type is also present to a small extent in the retina, and sildenafil actually has some PDE6 effect, which causes the occasional retinal and visual changes reported by some patients who take the drug. A variety of substances change nitric oxide synthase activity; one of them is the concentration of testosterone, or more specifically androgens, in the smooth muscle cells of the corpus cavernosum. The smooth muscle relaxation is controlled with neurotransmitters, particularly nitric oxide (4). EDWARD MORAN PAINTINGS FOR SALE & BIOGRAPHY So while the physician should ask about libido, the patient's response cannot eliminate the need for a testosterone determination. Several studies have shown that libido level is a better marker for depression and stress than it is for hypogonadism. Physicians used to think that if a patient had a low libido, he had low levels of testosterone. Now we know that about 60% of patients have organic ED, which we define as a vasculogenic, neurologic, hormonal, or smooth muscle abnormality; Oral phentolamine, a nonselective alpha-blocker, has been used successfully for facilitating erections and treating men with ED (32–35). Newer PDE5 inhibitors including vardenafil and cialis (IC351) are currently in phase III clinical trials. Sildenafil is also safe and effective in patients taking a variety of other medications. Efficacy of sildenafil citrate (Viagra) in improving erections. Ryan’s research focused on military history, and he is particularly interested in the conflicts fought by the United Kingdom from the Napoleonic Wars to the Falklands War. Now that you’ve read what Nicholas Moran has to say about these scenes, give the video a watch and see what you think! Moran exclaims, “That scene is basically why I became a tanker,” which is why it comes as no surprise that he gives Fury a 9/10 rating. At the end of the scene, the Shermans open fire using all of their machine guns and main cannons. In the scene, the four tanks keep in close formation, and the armor officer explains that, in an open field, this isn’t necessarily what one would choose to do. Ciao MMSCENE: Arthur Kelso by Borislav Utjesinovic Early agents such as trazodone, yohimbine, and delaquamine that depend on alpha blockade appear to demonstrate clinical effectiveness in generating erectile function (17). Clinical studies have revealed some restoration in erectile function compared with placebo using this selective alpha-2 agonist (17). Both selective alpha-1 blockers (doxazosin) and alpha-2 blockers (yohimbine) produce improved erectile function in clinical trials and clinical practice. Oil Paintings Reproductions Future treatment of ED with oral agents requires that agents be available for stimulation of erectile function from a variety of pharmacologic pathways. Similarly, the Treatment of Mild Hypertension Study has documented the improvement in erectile function in men with mild hypertension compared with placebo (31). In clinical studies, discontinuation due to adverse events was no higher in men taking the active drug than in those receiving placebo. Trazodone, an older but well-established antidepressant which does not work through the selective serotonin reuptake inhibitor mechanism, has been demonstrated to cause priapism and may restore erectile function in some patients (18, 19). Clinical trials involving yohimbine alone have shown only minimal improvement in erectile function compared with placebo (15). Sildenafil (Viagra), already approved for clinical use, has revolutionized the evaluation and treatment of ED (23). L-Arginine has been used to treat patients with ED (21, 22). Trazodone selectively inhibits CNS serotonin uptake, increases dopamine, and also has some peripheral alpha-adrenergic blocking activity. Delaquamine, a new, more potent and selective alpha-2 adrenoceptor antagonist, is approximately 100 times more potent than yohimbine. In one scene, Batman/Bruce Wayne (Christian Bale) attacks a convoy from the air, and the “tanks” tasked with protecting a truck within the line use cannons and missiles to fire back. The scene concludes with the tank and helicopter colliding head-on, resulting in the latter exploding. In reality, they’d have a greater chance of disabling the tank if they fired at the rear engine compartment. In one scene, John Rambo (Sylvester Stallone) climbs into a Soviet T-72 to take on what’s supposed to be a Mil Mi-24 Hind helicopter gunship. The list is updated annually before the start of each academic year, then locked for the duration of the school year. While currently available and approved oral erectogenic therapeutic agents include only sildenafil, and possibly apomorphine, the mechanisms of action currently manipulated by these agents are limited. Even patients with satisfactory cardiac status and exercise tolerance who may require an occasional short-acting nitroglycerin may not take PDE5 inhibitors such as sildenafil. The most important contraindication of sildenafil is in patients with cardiac disease who are taking nitrates such as nitroglycerin. We have included a “Date Added” field to flag new titles to this list.The addition of a free testosterone and a prolactin, perhaps a luteinizing hormone and follicle-stimulating hormone, may elucidate the androgen deficiency.At the end of the scene, the Shermans open fire using all of their machine guns and main cannons.Clinical studies have revealed some restoration in erectile function compared with placebo using this selective alpha-2 agonist (17).Such a decrease was prevented or reversed by testosterone replacement (11).Please check this list regularly for updates as those approvals continue to come in.He is arguably most famous for his series of 13 historical paintings of United States marine history.Several studies have proposed a list of laboratory studies to be done for initial evaluation of ED (9). More than 70% of men taking sildenafil reported improved erections compared with 10% to 30% of men receiving placebo. Recent years have witnessed the introduction of new oral agents for the treatment of ED, including sildenafil and sublin-gual apomorphine. This precursor of nitric oxide has been suggested as an oral supplement for patients with ED. Therefore, the above list is more current and reflects titles that have been added after August 15, 2025.Among the male members of the study, erectile function was one of the variables studied.Delaquamine, a new, more potent and selective alpha-2 adrenoceptor antagonist, is approximately 100 times more potent than yohimbine.It’s a nuanced capture of spaces that are often banal and ordinary that set the stage for individual titillation and engagement once the cameras start rolling.Although born in England in 1829, Edward Moran was one of the most prestigious American historical and marine painters of his generation.In our first year switching to this list, titles were added as approval requests were reviewed by authors and rights holders.In the penis, nitric oxide is available from the nitrergic nerve and the endothelial cells that line the lacunar spaces.Less than 50% of patients who were truly hypogonadal—meaning testosterone levels 80% of patients who were depressed had a low libido (6). "He taught the rest of us Morans all we know about art," stated his famous younger brother Thomas. Edward Moran, the oldest of the artistic Moran brothers, was acknowledged as the impetus behind the family's entry into the art world. Moran’s artistic merits earned him membership in the National Academy of Design as well as the American Watercolor Society. The paintings were widely exhibited before being given to the New York Public Library. Theodore Sutro, Thirteen Chapters of American History, 1905, illustrated by Moran In animal studies, Chamness showed that nitric oxide synthase decreased almost 50% in castrated rats. Several studies have proposed a list of laboratory studies to be done for initial evaluation of ED (9). Depression affects erectile function to a similar degree. Among the male members of the study, erectile function was one of the variables studied. Less than 50% of patients who were truly hypogonadal—meaning testosterone levels 80% of patients who were depressed had a low libido (6). Such a decrease was prevented or reversed by testosterone replacement (11). Beginning at about age 50, testosterone begins to fall off, and during that same time period, there is an increase in sex hormone binding globulin, which results in a substantial decrease in free testosterone and bioavailable testosterone. The addition of a free testosterone and a prolactin, perhaps a luteinizing hormone and follicle-stimulating hormone, may elucidate the androgen deficiency. As requests and approvals continue to came through, we added them to the list above. If your chapter uses OpenWater for Thespy registration, titles are pre-populated from the above list. Please check this list regularly for updates as those approvals continue to come in. In our first year switching to this list, titles were added as approval requests were reviewed by authors and rights holders. Peripheral stimulators and facilitators using various methods for producing erections must be available to begin therapy, and CNS stimulators and facilitators should be available to supplement these peripherally acting agents (36). NO indicates nitric oxide; NANC, nonadrenergic-noncholinergic neurons; GTP, guanosine triphosphate; GMP, guanosine monophosphate; cGMP, cyclic guanosine monophosphate; and PDE5, phosphodiesterase type 5. CGMP is broken down by the enzyme phosphodiesterase (PDE), and PDE inhibitors such as sildenafil and papaverine prolong the presence of cGMP and in fact facilitate relaxation in the corpus cavernosum. Through the guanylate cyclase system and through cyclic guanosine monophosphate (cGMP), nitric oxide produces an efflux of calcium from the cell, which then causes relaxation of the corpus cavernosum smooth muscle (Figure 2). The neurotransmitter is derived from the precursor L-arginine and is changed to nitric oxide through the enzyme nitric oxide synthase. In the penis, nitric oxide is available from the nitrergic nerve and the endothelial cells that line the lacunar spaces. After moving back to Philadelphia, Moran married Annette Parmentier (his second wife), whom he also apprenticed as a landscape artist in her own right. In animal studies, Chamness showed that nitric oxide synthase decreased almost 50% in castrated rats.He starts up, and to everyone’s surprise, it’s a smoke show!The neurotransmitter is derived from the precursor L-arginine and is changed to nitric oxide through the enzyme nitric oxide synthase.The effectiveness of selective alpha-2 blockade in vivo, therefore, is likely due to central rather than peripheral effects.At the time of his death, Moran was widely considered to be one of the most important 19th century marine painters.One of his more well-known exhibits, titled Land and Sea, showed 75 of his landscape and marine paintings in March 1871; these paintings were later illustrated in a catalogue by the same name.This type is also present to a small extent in the retina, and sildenafil actually has some PDE6 effect, which causes the occasional retinal and visual changes reported by some patients who take the drug.Recent years have witnessed the introduction of new oral agents for the treatment of ED, including sildenafil and sublin-gual apomorphine. In animal models, blockade of alpha-2 receptors resulted in increased sexual arousal and activity. The effectiveness of selective alpha-2 blockade in vivo, therefore, is likely due to central rather than peripheral effects. Similar studies by Baba and Alcorn have demonstrated changes in smooth muscle relaxation in the hypogonadal laboratory animal (12, 13). Holzweiler Returns to Copenhagen Fashion Week for FW26 L-Arginine has been used to treat patients with ED (21, 22).In clinical studies, discontinuation due to adverse events was no higher in men taking the active drug than in those receiving placebo.Both selective alpha-1 blockers (doxazosin) and alpha-2 blockers (yohimbine) produce improved erectile function in clinical trials and clinical practice.Newer PDE5 inhibitors including vardenafil and cialis (IC351) are currently in phase III clinical trials.Association between age and prevalence of erectile dysfunction.The authenticity of this scene is evident in even the smallest details.A variety of substances change nitric oxide synthase activity; one of them is the concentration of testosterone, or more specifically androgens, in the smooth muscle cells of the corpus cavernosum.The most important contraindication of sildenafil is in patients with cardiac disease who are taking nitrates such as nitroglycerin. In a small group of patients, a placebo-controlled trial of two 800-mg tablets given daily for 2 weeks improved erectile function compared with placebo (22). Early agents such as yohimbine, often considered an aphrodisiac in men, produces its effect on erectile function by blocking alpha-2 adrenergic receptors (14, 15). Since nitric oxide synthase activity decreases substantially with a decrease in testosterone level, androgen levels are critical for erectile function. The alpha-blockers, represented by doxazosin, were better than placebo in preserving erectile function (7). The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy. The erection persists until the stimulation is decreased and the nitric oxide disappears. The blood flow stimulates the endothelial cells that line the lacunar spaces to produce more nitric oxide, and the increased nitric oxide production causes relaxation of the corpus cavernosum smooth muscle tissue. As a result of electron microscopy, casting, and pharmacologic studies conducted in the past decade, a new theory for the mechanism of erections has become elucidated. In the 1970s, erections were thought to occur when valvular structures on the arterial side and an active valve on the venous side worked in a coordinated and syncopated fashion to shunt blood into the penis. Association between age and prevalence of erectile dysfunction. The crowd gets insane and this only increases the attitude to this hardcore powerlifting freak scene!!! In addition, his sons Edward Percy Moran (born 1862) and Leon Moran (born 1864), his other brother Peter Moran (born 1842), and his nephew Jean Leon Gerome Ferris, also became prominent American artists. At the time of his death, Moran was widely considered to be one of the most important 19th century marine painters. He chose to have thirteen paintings in the series because of the significance of the number in American history (13 colonies, 13 stars and stripes on the original US flag, etc.). In 1885, at the height of his career, Moran began on what would be considered his most important work - a series of 13 paintings representing the Marine History of the United States.