The evaluation of another study suggests the effects of PC in VOO on endothelial reactivity in hypercholesterolemic patients. According to the strong correlation between oxidative stress and inflammation directly related to cardiovascular dysfunction, the results of this clinical trial highlight the potential preventive activity of extra virgin HPOO in healthy individuals with CVD . A further study investigated how HPOO and LPOO affected HDL’s cholesterol efflux capacity in healthy adults. Reductions in SBP following HPOO consumption offer clinical backing for using HPOO as a dietary intervention against CVD in diverse groups . A double-blind, randomized, controlled crossover study enrolled 50 participants (mean age 38.5 ± 13.9 years, 66% women) who received either 60 mL/day of HPOO (360 mg/kg polyphenols) or LPOO (86 mg/kg polyphenols) for three weeks. Each factor affecting the bioavailability, bioaccessibility and bioactivity of polyphenols should also be considered. These data result from different studies where overweight/obese participants and patients with HIV or with hypercholesterolemia consumed 40–50 g/day of EVOO for 12 weeks 172,173,174. Finally, an MD supplemented with polyphenol-rich EVOO has probiotic effects promoting the growth of bacteria of the Lactobacillus and Bifidobacterium types. In addition, an acute intake of EVOO resulted in a significant reduction in the levels of plasma glucose, triglyceride, apolipoprotein B-48, and dipeptidyl peptidase-4 activity and in a significant increase in the peripheral blood levels of insulin and glucagon-like peptide 1 (GLP-1), as revealed by a randomized trial of 30 participants with impaired fasting glucose levels . In order to verify their beneficial impact on human health, more in vivo studies and well-designed clinical trials are still necessary. They are powerful antioxidants displaying anticancer, anti-angiogenic and anti-inflammatory properties. The action mechanism of polyphenols is pleiotropic, however, it mostly relates to their antioxidant activity. Join our unique tour in late October to witness this age-old tradition and taste the exquisite oil made from freshly picked olives. Immerse yourself in the sights, sounds, and flavors of the olive harvest. If you have the opportunity, I invite you to experience firsthand the olive harvesting and oil production process in Abruzzo. Oils with higher acidity are not considered extra virgin. If you have dry and dull hair, just start using extra virgin olive oil to make your hair moisturized and shining. Extra virgin olive oil is rich in vitamins and nutrients that are extremely good for the skin; they include Vitamin E & A, fatty acids, and minerals. The monounsaturated fats from olive oil are good for maintaining healthy triglyceride levels. Extra virgin olive oil also is an excellent diet that helps in controlling diabetes to a great extent. The oleic acid in olive oil is very good for balancing a healthy blood pressure level. EVOO component, oleocanthal, has been shown to reduce LCN2 levels in human primary chondrocytes obtained from osteoarthritis patients . Studies in humans and in animals showed that EVOO, particularly OLE, is a potent ligand of PAI-1 , indicating its potential benefits for thrombotic conditions. EVOO, particularly HT and OA, increases adiponectin level , supporting its cardiometabolic benefits. A study in animals demonstrated that EVOO inhibits TMAO formation ; however, data on humans are controversial 140,141,142,143. Because of these antimicrobial properties, ozonated olive oil has been found effective in managing several bacterial, viral, and fungal skin infections. Check out these six impressive benefits of ozonated olive oil! However, ozonated olive oil is the most prominent type and is widely available online and in many health food stores. Interestingly, populations residing in mediterranean regions have low rates of mortality (death) from heart disease. It’s primarily made up of monounsaturated fat (approximately 73%), a heart healthy fat that is a staple of the Mediterranean diet. In contrast, the natural extraction process used to produce Extra Virgin Olive Oil ensures it retains all the nutrients and antioxidants from the olive fruit. Extra Virgin Olive Oil (EVOO) is the highest quality olive oil available, extracted from the olive fruit without the use of any heat or chemicals. However, the high relative reduction in the prevalence of cardiovascular morbidity and mortality were not proportional to the limited findings about regulation of those traditional risk factors. EVOO polyphenols participate in the redox balance of the cell as antioxidants and as mild pro-oxidants, with ensuing upregulation of the antioxidant defenses of the cell. These effects, although not proven experimentally, could, at least in part, explain the healthy properties of the MD. After intestinal absorption and passage to the lymph, most polyphenols undergo phase I and phase II metabolism, with substantial biotransformation and production of methylated, sulphated, hydroxylated, thiol-conjugated and glucuronide derivatives and degradation products . Another study by Visioli et al. (2022) confirmed the neuroprotective effects of HT and HT-B in in the cell line 7PA2, a cell model for Aβ toxicity with mitochondrial dysfunction observed in AD . In this study, SH-SY5Y cells were co-treated with HT-B at concentrations of 5 and 10 μM for 6 h with 6-OHDA (100 μM), having been pretreated with 6-OHDA for 12 h. Specifically, HT-B effectively inhibited apoptosis in SH-SY5Y neuronal cells exposed to 6-hydroxydopamine (6-OHDA), a toxin closely related to Parkinson’s disease pathology. Indeed, additional studies are required to further validate and clarify the neuroprotective capabilities and mechanisms of olive leaf-derived triterpenoids. These compounds, notable for their antioxidant and anti-inflammatory properties, are essential in addressing the oxidative stress and chronic neuroinflammation characteristic of AD 33,36,37.Long-term consumption of EVOO lowers both systolic and diastolic BP, as demonstrated in several studies.Recently, in vitro and in vivo studies reported that oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism 99,100.Polyphenols from olive leaf extract showed synergistic effects as combined with standard chemotherapeutic agents .In conclusion, the brain health and Alzheimer's prevention capabilities of extra virgin olive oil are among its most significant and life-enhancing attributes. Rich in antioxidant compounds and healthy fats, this oil is a cornerstone of the Mediterranean diet. From its roots in the time-honored traditions of the Mediterranean, extra virgin olive oil has captivated the attention of nutritionists and scientists alike. The integration of olive oil in a nutritionally balanced diet represents a simple yet powerful strategy for promoting heart health. Further research is crucial to establish the specific role of EVOO bioactive compounds in cardiovascular health, particularly concerning their effects on gene expression, cellular signaling, and enzymatic functions . This impact was characterized by a reduction in serum TXB2 production, suggesting a potential anti-inflammatory role for olive oil . If you're looking for a simple, proven way to support your health without overhauling your entire diet, this is a great place to start. Its benefits are well established in both traditional diets and modern clinical research. It's your ultimate resource for elevating your olive oil knowledge and truly appreciating this amazing natural product. 2. Absorption and Distribution of Polyphenols Further, polyphenols have been demonstrated to suppress IL-6, microsomal PGE synthase-1 (mPGES-1) 179,180, and particularly, oleocanthal has been shown to inhibit COX-1 and COX-2 with a potency similar to that of ibuprofen . They counteract oxidative stress by directly scavenging ROS ; chelating metals ; and upregulating antioxidant enzymes such as catalase (CAT), thioredoxin reductase (TrxR), and heme oxygenase-1 (HO-1) . However, the bioavailability in the plasma varies between 0 and 4.0 µmol/l after the oral consumption of 50 mg aglycone equivalents of a polyphenol . Further, polyphenols are sensitive to heat, light, and air , and they can lose up to 50% of their potency in 12 months if not stored properly. Thus, it can be considered as a new anticancer compound for adjuvant therapy not only targeting different stages of cancer development, but also alleviating certain adverse effects in the course of cancer chemotherapy.The minor polar compounds in EVOO, including the secoiridoids OC and OH-OC, and phenolic alcohols such as tyrosol and HT, add to this protective arsenal.These changes in biomarkers indicate a reversal of some AD pathological markers in response to EVOO consumption.And the high content of monounsaturated fats makes it a smart choice for supporting heart health.The integration of olive oil in a nutritionally balanced diet represents a simple yet powerful strategy for promoting heart health.Extra virgin olive oil, or EVOO, is the highest grade of olive oil.More than 30 phenolic compounds might be found in EVOO beyond the renowned HT and Tyr, whose metabolites have been well talked over in the previous sections.Under these conditions, 2(E)-hexenal content is drastically reduced in a time- and temperature-dependent manner, while new and undesirable volatiles appear due to oleic acid oxidation, thus reducing its sensory properties . OLE, HT and other olive polyphenols protect cells against oxidative damage resulting from redox dyshomeostasis 29,30 and an excessive inflammatory response , among the main determinants of age-related pathologies such as cancer, T2DM, MetS, osteoporosis and neurological diseases 27,32. Indeed, EVOO polyphenols are well-known for their anti-inflammatory effects, exerted by down-regulating inflammatory mediators by transcriptional or post-transcriptional mechanisms and by modulating the activation of kinases involved in the onset of inflammatory process at different levels 2,11. Extra virgin olive oil (EVOO) polyphenols beneficial effects have widely been debated throughout the last three decades, with greater attention to hydroxytyrosol and tyrosol, which are by far the most studied. These are some of the properties of extra virgin olive oil that make it a unique product, not only in the kitchen, but also in health care. The study examined the effect of this fraction, tested at two different concentrations (20 and 40 μg/mL) for 24 h, on the SH-SY5Y cell line. The research utilized biophysical methods and cell biology techniques to understand how these compounds influence the fibrillation of Aβ42 (25 µM). In these experiments, CCF-STTG1 cells were treated with 100 nM Aβo, 5 μM OC, or a combination of 100 nM Aβo and 5 μM OC for 3 or 7 days. These results suggest a dual action of OC by promoting the clearance of Aβ from the brain across the BBB and stimulating its degradation, thus supporting the protective effect of OC consumption against AD . Olive oil could potentially reduce the risk of Alzheimer’s disease and age-related dementia. Interestingly, oleocanthal is an antioxidant that forms during the malaxation of Extra Virgin Olive Oil and is not found in any other food… not even olives (22). However, when cooked in Extra Virgin Olive Oil the levels of those beneficial compounds remained unchanged (16). Additionally, if you use an oil regularly you must consider the known health effects of its primary fats. Also, a meta-analysis including over 30 studies with 3106 participants found that EVOO consumption increases FMD values, confirming EVOO beneficial effects on endothelial function . Endothelial dysfunction and atherosclerosis are key mechanisms contributing to arterial impairment, substantially increasing cardiovascular risk . Their susceptibility to damage and disease, known as arterial vulnerability, affects blood flow and overall cardiovascular health. The results of the study demonstrated that phenolic compounds prevent lipoprotein oxidation, and this effect was correlated with the dose . Although studies on EVOO’s impact on weight are mixed, evidence suggests its role in mitigating obesity-related cardiovascular risks. Does cooking hurt EVOO? In addition, more recent findings have demonstrated the ability of OA to lower the aggregation to arachidonic acid, collagen and ADP . This finding is supported by evidence that a MUFA-rich diet diminished urinary excretion of thromboxane B2 (TXB2) metabolite , indicating diminished platelet activation. A preventive effect on this process may be achieved using EVOO, as demonstrated by several studies. In accordance, a study including 199 subjects showed a significant inverse association between daily OO intake (above 34 g) and IMT . Extra virgin olive oil shows promise in managing Type 2 diabetes and strengthening bones. Incorporating olive oil into a Mediterranean diet has been linked to less cognitive decline compared to standard low-fat diets. Similarly, oleacein has potent anti-inflammatory properties that can reduce chronic inflammation, a known risk factor for cancer development. Extra virgin olive oil: More than a healthy fat The definite polyphenols mentioned by EFSA are HYTY, TY, and further complex polyphenols of high molecular mass from which HYTY and TY (HYTY- and TY-related forms) can be derived, known as secoiridoids . Particularly, improvements in biomarkers involved in cardiometabolic pathways and subsequent cardiovascular events were recorded. Olive oils must contain at least 5 mg of Hydroxytyrosol (HYTY) and its derivatives (oleuropein and Tyrosol (TY)) per 20 g to qualify for the EFSA-approved health claim. The IOC has extra criteria, such as fixed ranges of other free fatty acids (palmitic, palmitoleic, heptadecanoic, heptadecenoic, stearic, and linoleic) and a higher threshold for eicosenoic acid (≤0.50 instead of ≤0.40) and total unsaponifiable matter (≤15 g/kg of EVOO). The IOC also has a higher FAEE threshold (≤35 mg/kg of EVOO) and includes further qualifying criteria, such as ≤0.20% of moisture and volatile matter in the oil, ≤0.10% insoluble impurities in light petroleum, and low levels of trace metals (≤3.0 for iron and ≤0.1 for copper). These statements have not been evaluated by the Food and Drug Administration.These products are not intended to diagnose, treat, cure, or prevent any disease. Discover nutrients you need for optimal health For example, one study showed that when broccoli was cooked with sunflower oil or even refined olive oil, several beneficial compounds in the broccoli (such as vitamin C) were reduced. Saturated fat (coconut oil) has zero known benefits while monounsaturated fat (olive oil) appears to significantly benefit heart health in the long run. A large analysis found that including olive oil in your daily diet could reduce the risk of type 2 diabetes by 13%. The Lyon Diet Heart study (1988–1992), a clinical trial conducted in France, investigated the adoption of the MedDiet after a first myocardial infarction. In addition to observational studies, clinical trials, both in primary and secondary prevention, have established a causal relationship between MedDiet and CVDs. Since then, a large body of research has proven the association between MedDiet and reduced CVDs risk. Several epidemiological studies and clinical trials have demonstrated the association between MedDiet and reduction of CVDs. The health advantages of olive oil have been widely acknowledged and extensively documented . The EFSA-approved health claim is only for olive oils with a minimum of 5 mg HYTY and its derivatives (oleuropein and TY) per 20 g. The different potential impacts on human health of various olive oil sub-types, such as Extra Virgin Olive Oil (EVOO), Virgin Olive Oil (VOO), Refined Olive Oil (ROO), and olive pomace oil, were identified. Olive cultivation, harvesting, and oil extraction have historically been central to the Mediterranean diet in this area, providing olive oil and olives as a main food source . The European Food Safety Authority (EFSA) confirms that olive oil’s polyphenols help protect blood lipids against oxidative damage; thus, EVOO, crucial in the MedDiet, could be a functional food component. Nevertheless, a large body of evidence conducted on individual bioactive compounds found in EVOO has consistently demonstrated their efficacy in modulating the pathways implied in CVDs development. CVDs are a chronic, lifestyle-related illness since nutrition, physical activity, and stress levels participate in its development. Lastly, the production of nutraceutical EVOO-based that concentrate specific bioactive compounds and enhance the bioavailability employing advanced delivery system (e.g., liposomes or nanoparticles) may be another opportunity. Only virgin type of olive oil consumption reduces the risk of mortality. But if you want to reap the full health benefits of this miracle oil, not just any olive oil will do… Home » 8 proven benefits you only get from extra-virgin olive oil The Oleocanthals in Extra virgin olive oil reduce the risks of breast, bowel, skin, and colon cancer. A growing number of studies have provided evidence that consumption of HPOO results in a significant decrease in both peripheral and central SBP in healthy adult subjects from Australia. The consumption of VOO, enriched with polyphenols, could have beneficial effects in patients with CHD as an adjunctive and complementary primary prevention to pharmacological treatment . Moreover, the protective properties of olive oil, particularly EVOO, have been extensively documented in several studies which have emphasized its potential in primary and secondary CVD prevention, T2D, and other chronic conditions 6,33. Scientific studies present the ability of polyphenols to modulate the human immune system by affecting the proliferation of white blood cells, and also the production of cytokines or other factors that participate in the immunological defense. Currently, promising therapeutic evidence—albeit in different stages of development, and too early to recommend specific EVOO-based dietary or nutraceutical interventions—is available for conditions such as obesity, NAFLD, neurodegenerative diseases, osteoporosis, cancer, and inflammatory diseases, amongst others. Regarding the absorption of olive leaf extracts, a study found a total phenolic content of 94 ± 2 mg/g of dry extract, with oleuropein as its major constituent (76.1 ± 0.8 mg/g of dry extract). In a study with in vitro enzymatic digestion of EVOOs from five different cultivars, Sevillana had the lowest total phenolic content (571 ± 1.6 nmol/g of EVOO) and the second lowest hydroxytyrosol content (6.11 ± 0.0 nmol / g of EVOO), yet the highest bio-accessibility index for total phenolic compounds (36%) and hydroxytyrosol (2452%) . Then, the effects of olive oil polyphenol intake on plasma LDL concentrations and atherogenicity were evaluated, whereas the effects on lipoprotein lipase (LPL) gene expression were checked in another subset study of EUROLIVE on 18 men. The trial examined markers of CVD risk related to cholesterol transport and metabolism, LDL oxidation, blood pressure (peripheral and central), arterial stiffness, inflammation, and cognitive performances in 50 healthy participants subjected to three weeks of daily administration of EVOO compared to a low-polyphenol olive oil . This first report correlated olive oil consumption with a reduced risk of visual memory decline in a population over 65 years old . Soler et al. showed instead that HT is metabolized in intestinal cells as sulfate, methyl (homovanillyl alcohol) and methyl sulfate (homovanillyl alcohol sulfate) while Tyr, because of the absence of an –OH group with respect to HT chemical structure, originated only sulfate and methyl metabolites. Moreover, HT, homovanillyl alcohol, and homovanillic acid are endogenously formed by dopamine oxidative metabolism and might be found in biological matrices though at low concentrations . Thus, main metabolites include O-methylated forms , aldehydes and acids formed via oxidation of the aliphatic alcohol , sulfates , glucuronides , and acetylated and sulfated derivatives as well as an N-acetylcysteine derivative . This process is very relevant, to the extent that polyphenols in their un-metabolized form could be almost undetectable in biological matrices . As reported in the previous section, HT and Tyr metabolites are predominant in circulation after absorption in the gastrointestinal tract of the parent compounds (Figure 1). 1. Anticancer Activity of Hydroxytyrosol Forty patients with at least one classic cardiovascular risk factor were randomly divided in two groups and received 25 mL EVOO or ROO daily for 6 weeks. After VOO ingestion, LDL, HT monosulfate and homovanillic acid sulfate, but not tyrosol sulfate, levels were increased, while the concentrations of biomarkers of oxidative stress, including oxidized LDL (oxLDL), conjugated dienes, and hydroxy fatty acids, decreased. These bacterial types, whose populations are increased following EVOO consumption, produce γ-aminobutyric acid (GABA), thus influencing the GABAergic firing pattern in the brain through enteric and vagal systems . Olive oil polyphenols, such as HT and other compounds generated from certain bacterial species (e.g., Lactobacillus) favored by EVOO polyphenols, can act as ligands of the aryl hydrocarbon receptor (AhR) that represent a key element in the status of mucosal immunity and in the homeostasis of the gut barrier . It is good to note that olive oil may be useful in preventing a few types of cancer. This article will briefly examine only the major health benefits of using this oil. One of the biggest benefits of using this oil is its ability to prevent inflammation, leading to several fatal diseases. The presence of antioxidants in this oil is very good, and it will help the body fight several diseases. It’s not a trend—it’s a long-term habit that supports healthy aging and overall vitality. Even though it’s a fat, EVOO may actually support healthy weight management. Olive oil is loaded with antioxidants that help neutralize free radicals. It also helps lower blood pressure and supports flexible, healthy blood vessels. It’s rich in monounsaturated fats like oleic acid, which help reduce LDL (bad) cholesterol and increase HDL (good) cholesterol. Higher cholesterol levels limit blood flow and increase the risk for cardiovascular diseases such as heart attacks and strokes. You can obtain high amounts of MUFA and PUFA from extra virgin olive oil, which is correlated with weight loss and the prevention of obesity. Thus, EVOO's benefits help improve skin health as it is rich in polyphenols, antioxidants, antibacterial, and MUFA properties. The polyphenols, antibacterial, and antioxidant properties found in olive oil prevent bacterial growth and accelerate wound healing. Extra virgin olive oil provides skin benefits — to soothe, heal, and protect. By choosing quality oil, you’re not just getting a delicious flavor; you’re also getting a concentrated dose of health-promoting compounds. While high-polyphenol olive oil might cost a bit more, consider it an investment in your well-being. Think of them as tiny warriors fighting off free radicals in your body, protecting your cells from damage, and promoting heart health. This process is integrated into many coordinated functions and involves transiently elevated levels of cytokines able to activate both the innate and the adaptive immune systems. Inflammation is an essential defense mechanism of the organism by which the immune system recognizes and eliminates harmful agents and infected cells and promotes tissue repair to restore body homeostasis. Furthermore, it is widely reported that OLE and HT act on AMPK signaling, and the latter has been considered as an attractive therapeutic target for antioxidant activity. Finally, spontaneously hypertensive rats fed with OLE (60 mg/kg/day) showed increased levels of Nrf2-dependent phase II enzymes, such as NQO-1 . Following Nrf2 activation and consequently its translocation to the nucleus, Nrf2 binds to antioxidant response elements (ARE); after binding, it acts on the transcriptional expression of several antioxidant enzymes, including superoxide dismutase (SOD), c-glutamylcysteine synthetase (c-GCS), glutathione S-transferase (GST) and NADPH quinone oxidoreductase-1 (NQO1) . Anti-aging effects The same mix of HT metabolites reduced the adhesion of the lymphocytes to aortic cells (HAECs) at all concentrations tested, with significantly greater reductions with HT metabolites than free HT. Specifically, that study highlighted the ability of EVOO phenols to reduce VCAM-1, ICAM-1, E-selectin and MCP-1 molecules secretion in mice aortas by inhibiting mRNA expression. The authors stated that a saturation of the glucuronide-specific RBC transporters could have occurred, limiting the availability of glucuronides inside RBC, or/and the glucuronides may have undergone a restricted hydrolysis to liberate active HT, which could then be absorbed by the cells. A broad spectrum of health-promoting properties of plant polyphenols comprises antioxidant, anti-inflammatory, anti-allergic, anti-atherogenic, anti-thrombotic, and anti-mutagenic effects. It would be of particular interest to assess the long-term cardiovascular safety and effects on hemostatic and inflammatory parameters of oleic acid-based formulations for enteral nutrition or oral supplementation—especially with minor components from EVOO—in groups with high cardiovascular risk. Furthermore, diet therapy with EVOO and the nutraceutical supplementation of its minor components currently have a very scientifically sound rationale after showing multiple beneficial effects—in both intervention and mechanistic studies—in important conditions for public health, such as cardiovascular health, lipoprotein metabolism, and diabetes mellitus. Participants in this study held one tablespoon of extra virgin olive oil in their mouths and swished it around for five minutes, one time per evening before going to bed, after brushing and flossing. Olive oil is also high in monounsaturated fatty acids (primarily oleic acid), which can lower LDL cholesterol, another potential contributor to olive oil's abundant health benefits.11 The main concern about the evaluation of EVOO phenols activities in vitro and in vivo is that the absorption and metabolism of these compounds once ingested lead to the production of different metabolites in the human body. Studies have shown that EVOO can improve insulin sensitivity and help regulate blood glucose levels, making it an ally in preventing and controlling type 2 diabetes. EVOO is not only a star ingredient in cosmetics, but its consumption provides essential nutrients for cell regeneration and skin hydration, combating dryness and expression lines. The monounsaturated fat and vitamin E content in extra virgin olive oil can help to increase a person’s overall fat intake, promoting testosterone production. These delightful treats showcase the rich flavor and aroma of our local extra virgin olive oil, combined with simple ingredients like flour, wine and a touch of sweetness from our homemade jams. One of my favorite examples is “tarallucci olio e vino” – traditional extra virgin olive oil and wine biscuits. Under these conditions, 2(E)-hexenal content is drastically reduced in a time- and temperature-dependent manner, while new and undesirable volatiles appear due to oleic acid oxidation, thus reducing its sensory properties . Interestingly, the loss of total phenolic content under frying seems to take place early during cooking and stabilize from 60 min of cooking . Nevertheless, EVOO is more resistant to oxidation and may produce higher yields of tocopherols at 180 °C than other monounsaturated fatty acid (MUFA)-rich cooking oils . When frying with EVOO, temperature seems a much more important factor than time; approximately, its phenolic content can be decreased by 40% at 120 °C and 75% at 170 °C with 15–60 min of cooking , while its scavenging activity may be halved at approximately 180 °C after just 15 min . Interestingly, hydroxytyrosol content may increase for the first hours when using EVOO of the Picual cultivar, while the intensity of loss of total phenolic content may be cultivar-dependent . Anyway, in spite of these and other data, the molecular mechanisms controlled by EVOO polyphenols in terms of antioxidant activity are not still clear; in fact, the reported effects were probably determined by the tissue localization of the enzyme and by the different concentrations of phenols used. Nowadays, researchers are focusing their attention on the antioxidant properties of natural compounds, without relevant side effects. In vivo, HT attenuated apoptosis in rat brain cells by modulating the levels of caspase-3 and NF-kB p65 subunit ; in high-fat diet (HFD)-fed C57BL/6 J male mice, daily doses of HT (5.0 mg/kg) attenuated the increment of NF-κB and SREBP 1c, and increased the activity of Nrf2 and PPAR-γ in the liver . The effect of OLE against Aβ peptide aggregation was dose-dependent and could be reproduced by diet supplementation with a mix of polyphenols from olive mill wastewater or by HT administered at the same dose as that of pure OLE 84,86. Future investigations should also consider genetic factors, like the APOEɛ4 allele, to tailor dietary interventions. Our advocacy for the inclusion of EVOO and its derivatives in the diet is based on a growing body of evidence suggesting a shift towards more effective strategies against the complex challenge of AD, emphasizing not just treatment but prevention and early intervention. The authors found that HP-EH-EVOO consumption caused changes in brain connectivity patterns, including reduced signal spectrum within the 1–13 Hz range and a decreased theta/beta ratio during eyes-open conditions. Olives and Extra Virgin Olive Oil as the main source of healthy fat, with additional powerful bioactive compounds, is central to the Mediterranean Diet.In contrast, one of our studies reported that HT glucuronide metabolites, specifically the mix of 3’-O-ß-D and 4’-O-ß-D-glucuronidated isoforms, could protect renal cells (LLC-PK1 cells as a culture model) against H2O2-induced lipid peroxidation-related membrane oxidative damage.Due to multiple technological processes, the content of polyphenols may vary in olive oil.In the process of crossing enterocytes, EVOO phenolic compounds are subjected to an important first pass metabolism through a classic phase I/II biotransformation.EVOO contains monounsaturated fats and polyphenols that can lower blood pressure.In a double-blind cross-over trial, 50 subjects (age 38.5 ± 13.9 years, 66% female) were randomized to receive 60 mL/day of HPOO (320 mg/kg polyphenols) or LPOO (86 mg/kg polyphenols) for three weeks.Type 2 diabetes is characterised by the reduced effectiveness of insulin, the hormone that moves glucose (sugar) out of the blood and into cells to be used as energy.Heart disease remains a leading cause of mortality worldwide, but one of the most significant extra virgin olive oil benefits lies in its potent ability to protect our cardiovascular system. However, if symptoms persist, it’s crucial to consult a healthcare provider to evaluate potential causes and develop an appropriate treatment plan. Antibiotic resistance can result in difficulties in managing common infections and may result in serious health complications. Regular use of antibiotics can lead to weight gain and cause bacteria to become resistant, meaning that antibiotic drugs are ineffective at treating microbial infections. Participants assigned to the Mediterranean diet supplemented with EVOO consumed 50 grams of EVOO, and those who adherence to the Mediterranean diet with nuts consumed 6 servings of nuts per week. Cardiovascular disease such as coronary heart disease is one of the top leading causes of death. In the 6 week study, participants were divided into two groups. Researchers conducted a randomized controlled study on 60 type II diabetes patients with dyslipidemia, an abnormal amount of lipids (triglycerides, cholesterol, or phospholipids) in the blood. Hypolipidemic agents, such as Atorvastatin, are administered to decrease lipid and lipoprotein in the blood to optimal levels. This liquid gold, a cornerstone of the famously heart-healthy Mediterranean diet, offers a wealth of compounds that actively work to reduce the risk of heart attacks, strokes, and other cardiovascular ailments. This listicle directly explores the key extra virgin olive oil benefits, demonstrating how this natural product can significantly enhance your well-being. Beyond its rich flavor, extra virgin olive oil (EVOO) offers a wealth of health advantages. Integrating these products into your daily routine can greatly enhance your experience with extra virgin olive oil, making it easier and more enjoyable to reap the benefits of it. Yet the spectrum of available medications, such as acetylcholinesterase inhibitors (galantamine, rivastigmine, and donepezil) and the N-methyl-D-aspartate (NMDA) antagonist memantine, offer only symptomatic relief. The blood–brain barrier (BBB) is essential for maintaining brain homeostasis and neuronal function, and its dysfunction in AD, characterized by heightened permeability, facilitates the entry of harmful substances and immune cells into the brain . Consequently, the surge in personal and financial burdens underscores the critical need for effective preclinical diagnosis and therapeutic management to prevent or arrest the disease’s progression before symptomatic onset. Monounsaturated fats also play a critical role in supporting the health of the myelin sheath, the protective insulating layer around nerve fibers that allows for rapid and efficient transmission of nerve impulses. This healthy fat is a fundamental building block for brain cell membranes, ensuring their integrity and fluidity, which is essential for proper neuronal communication. Furthermore, the predominant fat in EVOO is oleic acid, a monounsaturated fatty acid. The brain, with its high metabolic activity and lipid-rich content, is uniquely vulnerable to such oxidative damage, which is a known contributor to cognitive decline and neurodegenerative diseases. Exposure to light and heat breaks down the polyphenols and vitamin E in the oil. Not just the best-by date—look for when the olives were actually picked and pressed. This process keeps the natural antioxidants and nutrients intact. A truly high-quality EVOO is made from fresh olives that are cold-pressed without heat or chemicals. These studies consistently underscore the beneficial link between diets abundant in monounsaturated fat content and enhanced cardiovascular outcomes. Further bolstering olive oil’s reputation in promoting heart health are various randomized controlled trials. Heart disease and other cardiovascular diseases remain the predominant causes of premature death worldwide, posing a serious health challenge. Additionally, vitamin K supports bone health by helping to regulate calcium levels in the body, reducing the risk of fractures and osteoporosis. One of the standout nutrients is vitamin E, a powerful antioxidant that protects your cells from damage and supports skin health. EVOO Aids in Weight Loss Oleocanthal produces the burning sensation in the back of the throat that accompanies the consumption of freshly squeezed EVOO. The plant sources of plant polyphenols are, among others, bark, leaves, fruits, spices, berries, vegetables, roots, nuts and seeds, herbs, and whole grain products, from which they are transferred in processed foods of plant origin, including EVOO, red wine, green tea, coffee and turmeric. Biophenols are a family of over 8000 polyphenolic structures (those presently described) found in almost all plant families mainly as secondary metabolites, including several hundred isolated from edible plants 36,40. In addition, the chemical similarities of these structurally distinct molecules can explain why they can induce similar effects. Polyphenols can reach these effects by counteracting, at the molecular level, signaling pathways responsible for the cascade reactions involved in aging 9,10. In addition, this review will discuss the mechanisms by which EVOO improves arterial, myocardial, and blood health, as well as its role in regulating BP, low- and high-density lipoprotein cholesterol, endothelial function, and glucose levels. Furthermore, it modulates biomarkers of cardiovascular health, such as C-reactive protein, low-density lipoprotein (LDL) cholesterol, and NT-proBNP, aligning with improved hemostatic balance and reduced arterial vulnerability. Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, driven by complex interactions among genetic, environmental, and lifestyle factors, with diet playing a pivotal role. We post frequently and discuss all things related to the olive tree and health Because of limited scientific evidence, using ozonated olive oil for therapeutic purposes has been controversial in the past. Ozonated olive oil is a type of oil that has been infused with ozone, a gaseous molecule containing three oxygen atoms. This diet is characterised by the high consumption of Extra Virgin Olive Oil, legumes, unrefined cereals, fruits and vegetables; moderate to high consumption of fish and dairy products; and low consumption of non-fish meat. Olives and Extra Virgin Olive Oil as the main source of healthy fat, with additional powerful bioactive compounds, is central to the Mediterranean Diet. While its main fatty acid, oleic acid, is considered important to these effects, EVOO has other biological properties that depend on, or are potentiated by other minor components of this oil. If you have any health concerns or concerns about potential risks, you should always check with your physician, licensed health provider or health care practitioner. Researchers studied the impact of cooking with EVOO on its health benefits, and what they found was reassuring. The studies on the 3T3-L1 adipocyte cell line have shown that HT stimulates mitochondrial biosynthesis which is reduced in the course of diabetes mellitus. Free radical scavenging properties of HT have been convincingly confirmed in studies on rats with alloxan-induced diabetes mellitus . Oleuropein, tyrosol, hydroxytyrosol, verboscoside, ligustroide, demethyleuropein were all proven to protect against the coronary artery disease 43,44,45,46 or cancer 43,47,48. It boasts monounsaturated fatty acids known for promoting heart health and aiding in weight management. Nevertheless, additional multicenter clinical studies, which enroll a wider range of patients are needed to validate and support this evidence and to clarify the potential beneficial consequences of EVOO consumption. In conclusion, this systematic review analyzed the supplementation of VOO, specifically EVOO, in relation to cardiovascular dysfunction, highlighting its contribution to the prevention of CVD and showing the beneficial activity of EVOO polyphenols to counteract cardiovascular damage. This could be achieved by establishing clear innovative guidelines to include it as part of a diet designed to protect heart health . To investigate the impact of different olive oil capsule formulations using innovative and pragmatic trial designs focused on low-cost methodologies could be a realistic approach to exploring this prominent topic . 2. In Vivo Preclinical Studies These figures powerfully illustrate how the high concentration of monounsaturated fats in EVOO contributes to a significant reduction in cardiovascular risk and supports healthier cholesterol levels. Oleocanthal, for instance, has been shown to possess anti-inflammatory properties similar to ibuprofen, working to quell inflammation pathways that contribute to cardiovascular disease. Furthermore, studies suggest oleic acid can have beneficial effects on genes linked to chronic diseases, underscoring its deep cellular impact. Refined olive oil, on the other hand, lacks the same level of beneficial compounds found in extra virgin olive oil, making the latter more effective in cancer prevention. Incorporating olive oil into your regular diet is a flavorful way to protect your heart and promote overall cardiovascular health. This aligns with other research showing that the antioxidant compounds and beneficial fats in olive oil help improve vascular health and reduce inflammation. The evidence suggests that incorporating extra virgin olive oil into one’s diet not only helps in managing current heart conditions but also serves as a preventive measure. Consuming extra virgin olive oil in moderation is the right way to leverage its benefits.The saturation and unsaponifiable fraction of these two lipids are different, but extra virgin olive oil, which is rich in polyphenols and other minor components, is beneficial to health, especially by improving cardiometabolic parameters .If you keep ornamental plants, pour a small amount of olive oil on a soft cloth and clean their scales.Now, as a cultivator and an informed voice in this field, I share these rich insights and the legacy of olive oil on this website.During the intervention, participants consumed 50 mL of olive oil daily, divided into three doses. Regarding the first aim, the promising avenues for prevention and disease modification offered by EVOO and its bioactive constituents are elucidated based on preclinical and clinical findings. EVOO, derived from the initial pressing of olive fruit by mechanical means, comprises approximately 95% glycerol and 5% nonglycerol components . Projections indicate a substantial rise in diagnosed cases, making it crucial to explore innovative strategies. The imperative to identify novel targets and tools for AD prevention and modification arises from the elusive nature of the disease’s etiology. While these drugs improve memory and daily functioning, they fail to provide a cure or halt the disease’s progression . Additionally, the long-term consumption of a MedDiet rich in EVOO may preserve kidney function, as shown by a reduced decline in eGFR in CHD patients with Type 2 diabetes mellitus (T2DM) . Arteries are essential conduits of the cardiovascular system, carrying blood from the heart to other districts of the body. This randomized control trial was conducted on healthy subjects among several European populations. For example, the PREDIMED study found a modest reduction in waist circumference among EVOO consumers over five years . EVOO has been shown to reduce both CRP and IL-6 levels , underscoring its anti-inflammatory properties. Besides its role in CRP synthesis, IL-6 has been found to predict cardiovascular events , and its levels correlate with an increased risk of CHD . This section provides a comprehensive overview of cardiovascular biomarkers, categorized by their role in CVD risk assessment, along with the effects of EVOO on these biomarkers. Contrasting evidence exists regarding EVOO’s effect on PAI-1 levels, with reductions observed in some studies 75,76 but not in others , possibly due to variations in participants’ metabolic status or control diets. Thus, further studies are required to elucidate the effects of EVOO consumption on hemostatic cascade. While more research is always welcome, particularly regarding optimal dosages, the existing evidence strongly supports incorporating high-quality extra virgin olive oil as a cornerstone of a brain-healthy diet. One of the standout features contributing to these extra virgin olive oil benefits for the brain is the ability of some of its key compounds to cross the formidable blood-brain barrier. Its unique components, especially oleocanthal, establish it as a powerful functional food in the fight against chronic diseases linked to inflammation, making this one of the most compelling extra virgin olive oil benefits. Organizations like the International Olive Council (IOC) also play a role in promoting the health benefits of olive oil, including its anti-inflammatory properties, by setting quality standards and disseminating research. In a study of 2,436 adults, those who consumed more than 2.7 tbs of extra virgin olive oil per day had a 27% lower chance of having NAFLD compared to those who consumed 0–1.75 tbs daily. The EPIC-Europe study, a long-term study of over 500,000 participants, across 10 European countries, confirmed the cardiovascular benefits of MUFAs in EVOO, highlighting its protective effects on heart health. A large analysis of 19 previous studies found that those with a higher consumption of olive oil had a lower risk of breast cancer and cancers of the digestive system (20, 21). Unlike regular refined olive oil, EVOO contains more than 200 antioxidant plant compounds, including polyphenols. The ability of plant polyphenols to interfere with biochemical homeostasis has also been taken into consideration , and epigenetic modifications of chromatin have been reported to also be involved in these effects 16,17. An important feature of the MD is the daily consumption of a vast array of phytonutrients including vitamins and plant phenols, which provides its similarities with the Asian diet. Physical exercise, mental activity and diet, intended as the complex of foods and nutrients taken daily by a person, are three pillars of a healthy lifestyle. These compounds, including oleuropein, hydroxytyrosol, and tyrosol, help neutralize free radicals – unstable molecules that can cause oxidative stress and damage cells, contributing to inflammation.Another randomized, controlled, parallel-arm, clinical trial was carried out to compare the effects of olive oil with high (EVOO) or low (ROO) polyphenol levels in patients undergoing coronary angiography.It is widely recognized that oxidative and nitrosative stress as well as inflammation are the major abnormalities underlying neurodegeneration and that antioxidant molecules, such as olive oil polyphenols, restore neuronal function through the amelioration of the redox status.Vitamin E, a fat-soluble antioxidant, protects cell membranes from oxidative damage.The proximity between olive groves and mills helps reduce environmental impact while enhancing quality.Actually, accurate studies on the effective dose of olive polyphenols to be administered daily to humans to obtain significant protection are still lacking; at any rate, the amount of OLE and other plant polyphenols taken daily in foods appears not adequate to ensure a dose suitable to produce short-term acute effects.Extra virgin olive oil is an essential pillar of Italian cuisine. Although the cardioprotective effects of EVOO are consistently mixed with evidence provided by other components of the dietary pattern, such as the MedDiet, the difficulty of separating the specific effects of EVOO is acknowledged. The number demonstrated that increasing the adherence to a Mediterranean dietary pattern by 20% would produce annual savings in cardiovascular-related cost by USD 8.2 billion in the US . Technological advancements have enormous potential for improving the quality and efficacy of EVOO; in this regard, genetic engineering may be a novel approach to develop olive cultivars with higher concentrations of polyphenols. Alternatively, explore the robust flavors of La Tourangelle, known for their Organic Extra Virgin Olive Oil crafted from high-antioxidant Picual olives harvested in Spain. Store your olive oil in a cool, dark location to maintain its nutritional value and flavor over time. By thoughtfully incorporating this versatile oil, you enrich your diet with its many health advantages. In baking, a lighter olive oil can be a great choice if you’re sensitive to its robust flavor. Opt for high-quality oils certified by the International Olive Council (IOC) or the North American Olive Oil Association to ensure authenticity and health benefits. Its unique combination of antioxidants, oleic acid, squalene, and other bioactive compounds work synergistically to protect cells, reduce inflammation, and potentially hinder cancer development.These findings were further confirmed in vivo in 4- and 10-month-old TgCRND8 mice fed a diet supplemented with OLE (50 mg/kg of diet/day) for 8 weeks.During frying, hydroxytyrosol and tyrosol may have the lowest thermal resistance, and deep frying and pan frying may affect the type of phenolic compounds lost during heating .Extra virgin olive oil is a key component of the Mediterranean diet that is thought to contribute to many of the diet's health benefits.To assess the impact on cardiovascular events, a follow-up clinical study compared a VOO-rich Mediterranean diet to a low-fat diet in participants with initial CHD, observing outcomes after 7 years.All olive oils are rich in monounsaturated fatty acids (MUFAs), particularly oleic acid.Compared with the effects of HT, 3-O-HT glucuronide and 4-O-HT glucuronide at physiological concentrations of 10 μM and 25 μM, induced in vitro a milder change in mRNA expression levels of both CCAAT-enhancer-binding protein homologous protein (CHOP) and glucose regulated protein GRP78 immunoglobulin heavy chain binding protein (BiP). The knowledge stemming from these data will allow us to better understand the beneficial effects, for human wellness, of the MD, the importance of its content in plant polyphenols and the role of the latter in disease prevention and, possibly, therapy. This review begins from the chemical structure, abundance and bioavailability of the main EVOO polyphenols to highlight the effects and the possible molecular mechanism(s) of action of these compounds against inflammation and oxidation, in vitro and in vivo. The lack of anti-inflammatory drugs without side-effects has stimulated the search for new active substances. Olive oil’s antibacterial and antifungal properties make it an excellent natural pet care product.Its phenolic compounds can enhance insulin sensitivity, helping regulate blood glucose levels.Vissers et al. suggested that the different polarities of the various phenolics might play a role in the absorption of these compounds.Observational studies have shown a lower incidence of some cancers in regions where olive oil consumption is high (19).Emerging research suggests that extra virgin olive oil may offer protective benefits against certain types of cancer, including breast, colon, and prostate cancer.Another isomer, hydroferulic acid, has proved to be an inhibitor of in vitro platelet activation more effective than its phenolic precursor FA . They believe in the exceptional taste and health benefits of top-notch olive oil, and their commitment is to share that love and quality with you. Olive Oil Lovers dedicates their business to providing you with the absolute finest extra virgin olive oil. Craving the convenience of having organic extra virgin olive oil delivered straight to your doorstep? However, research by the National Library of Medicine found that mortality rates for these diseases were low in Mediterranean countries where olive oil is a dietary staple. Other noteworthy polyphenols are chlorogenic and caffeic acids that are found in coffee and other plants. They also show anti-inflammatory properties due to inhibition of cellular nitric oxide production. According to some, pulp and peel of ginger rhizomes exhibit in vitro antiproliferative activity against colon cancer cells. Except from the European olive, known as Olea europea, there are many other plants rich in invaluable polyphenols. EVOO has diverse beneficial health properties and a well-established role in clinical nutrition. Clinical nutrition could also benefit from further studies comparing liver function under different OO-based ILEs in a randomized fashion in different clinical populations. Considering the aforementioned and possible future lines of research, it would be of high interest to develop intervention trials to further evaluate the effect of EVOO and its minor components on hard endpoints in high-impact clinical conditions such as heart disease, NAFLD, IBD, bacterial infections, or HIV. In this complex landscape, EVOO and its phenolic compounds emerge as multifaceted players with potential influences on these key pathological hallmarks 34,51. The diverse spectrum of EVOO’s phenolic content underscores its potential as a natural therapeutic agent in the intricate pathology of AD, highlighting the need for continued research into its nuanced role in neuroprotection and disease mitigation 30,33,34,35,36,37. The minor polar compounds in EVOO, including the secoiridoids OC and OH-OC, and phenolic alcohols such as tyrosol and HT, add to this protective arsenal. EVOO is renowned for its culinary virtues and its rich array of phenolic compounds, which are garnering increasing attention for their potential therapeutic implications in AD 30,33,34. In particular, the importance of the antioxidant activity of lipophilic and hydrophilic phenols in EVOO has emerged . Antioxidants inhibit oxidation; therefore, to react to oxidative stress, organisms maintain complex systems of antioxidants, primarily glutathione (GSH). The overproduction of ROS correlates with lipid, protein or DNA damage involved in the onset of degenerative diseases; accordingly, cell defenses against a rise in ROS are fundamental . Recently, in vitro and in vivo studies reported that oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism 99,100. Taken together, these data suggest that OLE and/or its metabolite, HT, can be effective to combat cellular alterations underlying AD symptoms in the absence of undesirable side effects. The consumption of olive oil is an important factor in the Mediterranean diet, and is generally believed to be beneficial for health . Our studies on polyphenols of olive oil (especially oleuropein and hydroxytyrosol) also confirmed their anticancer potential on proliferation and cell death of number of cancers (osteosarcoma, neuroblastoma, breast cancer). Phenolic compounds (oleuropein, protocatechuic acid) of virgin olive oil have also been shown to inhibit macrophage-mediated LDL oxidation . Antioxidant and anti-atherogenic effects of olive oil polyphenols, like oleuropein and hydroxytyrosol, have been vastly confirmed in the literature 52,53. Interestingly, significant anti aggregation and neuroprotective effects of a diet supplemented with OLE, HT or a mix of polyphenols from olive mill wastewater were reported in the TgCRND8 mouse model of Aβ deposition. In the past, the health effects of EVOO were attributed mainly to the presence of oleic acid; however, more recently, attention has been focused on phenolics, a class of bioactive compounds including phenolic acids, phenolic alcohols, flavonoids, secoiridoids and lignans . Here, the results of studies on the polyphenols produced by the olive tree and found in EVOO will be reviewed, with a special focus on the antioxidant and anti-inflammatory properties of these molecules. Differences Between Types of Olive Oil Lastly, OA improves insulin sensitivity through PI3K-AKT activation and increases adiponectin levels . It also prevents LDL oxidation, inhibits vascular smooth muscle cells proliferation, and protects from atherosclerosis . Mechanistically, OA promotes the elimination of excess cholesterol from cells through the activation of ATP-binding cassette protein A1 (ABCA1) . Further, atherosclerosis progression was delayed in mice who were fed a diet rich in EVOO obtained through centrifugation process compared to mice that received EVOO obtained though standard process. A trial conducted among the older Australian population has demonstrated the reduction in F2-IsoPs subsequent to EVOO consumption . Emerging evidence highlights the endothelium as a significant target for EVOO polyphenols, which exert modulatory effects on its diverse functions. However, the reductions in macrophage accumulation and inflammatory markers were independent of the phenolic content . Claro et al. demonstrated that the phenolic compounds were able to restore endothelial function and to reduce lipid accumulation within the atherosclerotic plaque. Therefore, this systematic review aims to report on the benefits of VOO consumption for CVD patients, focusing on improved cardiac biomarker levels.The only clear effect of the intake of a high-polyphenol olive oil was on HDL-cholesterol levels, on LDL and nucleic acid oxidation and on the plasma antioxidant activity, in agreement with previous meta-analyses .In this study, SH-SY5Y cells were co-treated with HT-B at concentrations of 5 and 10 μM for 6 h with 6-OHDA (100 μM), having been pretreated with 6-OHDA for 12 h.The polyphenols compound in this oil is good antioxidant and anti-inflammatory properties.The polyphenols in EVOO provide your body with extra defense against oxidative stress, which is a major driver of long-term health issues.In elderly individuals, a Mediterranean diet appears to lessen the inflammatory response after meals in mononuclear cells, unlike diets high in saturated fat and carbohydrate-PUFA .In a future article, we’ll look at how this ingredient can go beyond the kitchen and support your health in unexpected ways. The correlation between BMI1 upregulation and a decrease in these detrimental processes suggests a protective mechanism triggered by EVOO consumption . These changes in biomarkers indicate a reversal of some AD pathological markers in response to EVOO consumption. The MCI patients were further divided based on the duration of EVOO consumption (1 month and 12 months) . Improves Skin Health The profile and concentration of compounds in the unsaponifiable fraction of EVOO depend on the cultivar , irrigation , mode of cultivation , and ripening of the fruit . The chemical composition of EVOO depends, among others, on the place of production, cultivar, and degree of ripeness of the olives, which can vary significantly 6,7,8,9,10,11. If no evidence was available, then a secondary search was conducted selecting other type of studies and/or animal models. When not available, evidence from other type of studies and/or animal models is reviewed. The aim of this narrative review is to synthesize and illustrate the various characteristics, clinical applications, and mechanisms of action of EVOO and its components in the field of clinical nutrition and dietetics. In consideration of this issue, it has been observed a correlation between plasma TAC, an indicator of the body’s overall antioxidant status, and a decreased risk of developing chronic diseases, including CVD . Therefore, the inclusion of EVO oil in the daily diet could represent an effective strategy for cardiovascular risk reduction . The polyphenols in EVOO exert anti-thrombotic and anti-inflammatory activity, improve the bioavailability of nitric oxide, and reduce BP. Effectively, in a crossover design experiment, olive oil was found to have a significant positive effect on inflammatory markers in the blood. Extra virgin olive oil is rich in monounsaturated fats, which help lower bad cholesterol levels and reduce the risk of heart disease. OWI also clarified that while extra virgin olive oil somehow benefits sperm count, excessive intake of vitamin E has been linked to an increased risk of prostate cancer. Researchers have linked the consumption of extra virgin olive oil to improved fertility and reproductive health in men. An in vitro study investigated the neuroprotective and anti-inflammatory effects of a triterpenoid-enriched fraction from olive leaves . EVOO’s phenolic compounds offer anti-inflammatory benefits, possibly reducing chronic neuroinflammation by downregulating pro-inflammatory cytokines 57,59,61. This search strategy incorporated key terms, such as EVOO, phenolic compounds, and Alzheimer’s disease, to capture studies that specifically addressed the biochemical or therapeutic effects of EVOO or its constituents on AD. If you are prone to cardiovascular diseases, you should immediately switch to olive oil for better heart health. Extra virgin olive oil contains nutrients and vitamins, such as Vitamin E, A, and antioxidants, which improve the hair’s health. Extra virgin olive oil is an essential pillar of Italian cuisine. Additionally, the preventive potential of EVOO in at-risk populations deserves further exploration, as does the role of dietary patterns and the timing of EVOO consumption in AD prevention. Further exploration into the synergistic effects of EVOO phenolic compounds with existing AD treatments may unveil comprehensive management strategies, potentially leading to integrated therapeutic approaches. Fifty participants, aged between 38 and 55 years old (with a standard deviation of 13.9), 66% of whom were female, took part in a double-blind, randomized, cross-over study. FVOO provided greater benefits on endothelial function than a standard natural VOO in pre- and hypertensive patients . A three-week randomized, crossover, double-blind, controlled intervention study was conducted on 58 participants who received a daily dose (30 mL) of three oils. The evidence suggests habitual EVOO-rich MedDiet consumption improves endothelial function in prediabetic and diabetic patients . The data suggested that VOO should be consumed in larger quantities and with greater frequency than other fats, ideally from early life onwards, for primary CVD prevention . A study conducted by the German Research Center for Food Chemistry in 2013 found that foods prepared in olive oil are more filling and quickly satiating. The monounsaturated fat in olive oil is the healthy fat required for the body. The healthy fat supplied by olive oil also reduces depression and stressful anxiety. The main reason is the liberal usage of olive oil in this diet. Excessive heat will damage the very compounds you’re trying to preserve. Once the bottle is opened, oxygen slowly starts to break down the oil’s polyphenols and vitamin E. Another helpful habit is replacing less healthy fats. The good news is that you don’t need to change your entire diet or learn a bunch of new recipes to make it work. Just one or two tablespoons of EVOO a day can create a ripple effect in your health. Studies have consistently demonstrated that EVOO decreased the risk of type 2 diabetes 28,29 by improving postprandial glucose regulation and insulin sensitivity and increasing glucagon-like peptide-1 incretin pattern . Type 2 diabetes, characterized by insulin resistance (IR) and hyperglycemia 25,26,27, is a major contributor to cardiovascular events. Both the EVOO and nuts-supplemented group demonstrated a 30% reduction in major cardiovascular events. Decreased inflammation, insulin resistance, and body mass index have been the primary factors explaining the 25–30% of MedDiet benefits. To further validate the findings across these clinical studies, a meta-analysis was conducted by Sofi et al. in 2008 analyzing eight cohorts and involving 514,816 subjects. Rich in Vitamin E, potent antioxidants, and beneficial fatty acids, EVOO offers a natural route to radiant skin and lustrous hair. The key is to harness its satiating power and metabolic advantages through mindful consumption, making it a delicious and healthy component of a balanced lifestyle aimed at achieving and maintaining a healthy weight. The link between EVOO consumption and reduced cancer risk isn't just theoretical. The MUFA diet group participants resulted in a 48% reduction in the daily dosage of antihypertension medication, while participants in the PUFA diet reduced their daily medication dosage by only 4% (1). Current research suggests that olive oil can reduce blood pressure. And they can improve or worsen our risk for chronic diseases. Given its multitude of reported health benefits, it seems you have nothing to lose. It seems however that the antioxidant potential of olive oil is the primary factor contributing to protection against cancer 72,73. Interestingly, olive oil polyphenols were proven to protect biological membranes against oxidative modification and losing structural integrity. The obtained data indicate as well the plausible synergism between polyphenols of olive oil and standard chemotherapeutics (data not published yet). The flesh of healthy olives contains about 2–3% of phenolic substances in the form of glucosides and esters. Thank you for choosing GSK-Live-Healthy as your trusted source of information on healthy living and wishing you all the best on your journey towards a healthier you! As someone passionate about health and fitness, he has devoted his time to researching and sharing the latest insights on how to live a healthy, fulfilling life. He is eager to share his expertise with those who want to live their healthiest and most fulfilling lives. Taking into consideration all the results from these epidemiological studies supporting a causal link between the intake of olive oil polyphenols and effective benefits, in November 2011 the European Food Safety Authority (EFSA) approved two health claims regarding the salutary role of olive oil consumption. Regular consumption of extra virgin olive oil has many health benefits. Dietary changes can provide protective effects against cardiovascular diseases by incorporating 50 grams of extra virgin olive oil or 6 servings of nuts per week to decrease cardiovascular diseases. Because olive oil, particularly extra virgin olive oil, has substantial health benefits. These compounds, notable for their antioxidant and anti-inflammatory properties, are essential in addressing the oxidative stress and chronic neuroinflammation characteristic of AD 33,36,37. In this context, the Mediterranean diet emerges as a promising avenue, supported by epidemiological and clinical studies highlighting its remarkable impact on cognitive health . Extra virgin olive oil helps in conditioning, nourishing, and improving hair thickness. As the global population continues to age, the frequency of AD is on the rise, rendering it a profound healthcare challenge. Aging represents the most formidable risk factor for AD, with a prevalence of 10% in individuals over 65 years old, which escalates to 40% in those over 80 years old . AD is the leading cause of dementia, contributing to a substantial 60–80% of all dementia cases and ranking as the sixth leading cause of death among individuals aged 65 and above in the United States alone . Alzheimer’s disease (AD) is a complex and progressive neurodegenerative disorder primarily affecting elderly people; it is characterized by cognitive decline, memory impairment, and impaired daily functioning . Findings indicate that EVOO and its phenolic constituents influence key pathological processes of AD, such as Aβ aggregation, tau phosphorylation, and neuroinflammation, while also enhancing BBB integrity and reducing oxidative stress. EVOO represents a valuable addition to dietary strategies aimed at reducing the global burden of cardiovascular diseases. Future directions emphasize the need for advanced extraction techniques, nutraceutical formulations, and personalized dietary recommendations to maximize its health benefits. Numerous clinical and preclinical studies have demonstrated that EVOO’s properties reduce major modifiable cardiovascular risk factors, including hypertension, dyslipidemia, obesity, and type 2 diabetes. The Olive Wellness Institute is a science repository on the nutrition, health and wellness benefits of olives and olive products, which is all subject to extensive peer review. For the healthiest and most nutritious olive oil make sure to source yours locally and check for this Australian certification triangle.