A systematic review of the literature for placebo-controlled clinical trials investigating traditional and herbal medicine was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines . These can be described as ‘a group of diverse medical and healthcare systems, practices, and products that are not presently considered to be part of conventional medicine’ 17,18. Pharmaceutical treatments for ED are typically phosphodiesterase-5 inhibitors that inhibit the outflow of blood from the penis to induce erection. Importantly, improved diet and exercise should be considered, particularly in patients with obesity or diabetes mellitus. Based on the results, Korean ginseng, Pygnogenol and Prelox, Tribulus terrestris, Lepidium meyenii, L-arginine, acupuncture and lifestyle interventions were the more predominantly investigated treatments interventions for ED. Medical Professionals Currently, the treatment of ED mainly relies on phosphodiesterase type 5 inhibitors (PDE5Is), with an overall efficacy rate ranging from 77% to 84%.9 However, the effectiveness of PDE5 inhibitors for ED patients with accompanying diseases such as diabetes, severe cardiovascular disease, hyperlipidaemia, and testosterone deficiency is not ideal. Recruitment will be conducted from patients who have a strong willingness to try using only traditional Chinese medicine treatment (This is very common in traditional Chinese medicine hospitals.). However, approximately 20% of patients do not experience improvement in overall sexual satisfaction (OS) after taking PDE5Is. With the right approach, these ancient herbs can help restore vitality and confidence in your sexual health. Erectile dysfunction can be a frustrating and sensitive issue, but natural remedies such as Chinese herbs offer a promising alternative for many individuals. Old men, wishing to enjoy sexual pleasure or to secure the affections of women, as well as those suffering from senile decay or sexual incapacity, and persons weakened with sexual excesses may also use Vajikaran remedies. An excerpt of the definition derived from these texts suggests that a youth in sound health taking regularly some sort of Vajikarana remedy may enjoy the pleasure of youth every night during all the seasons of the year . Vajikaran as a concept has been defined in the Rig Veda and the Yajurveda, the first written texts of medicine, in Ayurveda. It was shown that Cistanche extract shortened the erectile latency and prolonged the erectile duration in castrated rats. Hence the precise mechanism underlying its pro-erectile property needs to be investigated further. It was reported that osthole had a relaxant effect on strips of rabbit corpus cavernosum, which might involve the release of NO from endothelium and inhibition of phosphodiesterase (16). The hunt for natural supplement from medicinal plants is being intensified mainly because of its fewer side effects. An aphrodisiac is an agent (food or drug) that arouses sexual desire. Procreation was an important moral and religious issue and aphrodisiacs were sought to ensure both male and female potency. Different approaches to synthesize and/or modify natural ginsenosides can also be considered to increase the efficacy/potency, metabolic stability, and oral bioavailability for clinical applications. Stress reduction Patients aged 18–65 years with mild or moderate ED with or without hypoactive sexual desire disorder were enrolled. Terrestris herbal extractum siccum, and the content of furostanol saponins was no less than 112.5 mg. One randomized, double-blind, placebo-controlled study found that T. The duration of this study spanned a period of 3 months (Roaiah et al., 2016). However, there were only 30 study subjects enrolled without control group. If you have experienced a recent dramatic change in testosterone levels, please consult your personal healthcare provider. In closing, decreased testosterone levels are a function of aging. Cynomorium is a parasitic herb with a long history of usage in traditional medicine for treating various male health complaints. A double-blind, placebo-controlled trial involving aging, overweight males found that ashwagandha helped to boost testosterone levels by 14.7%, compared to placebo, over the course of 16 weeks. It is the prenylacetylation of kaempferide 3,7-O-diglycoside, icariin on erectile dysfunction and established its dose-dependent selective inhibitory effect on phosphodiesterase-5 (PDE5). In case of streptozotocin and alloxan induced hyperglycemia, the aqueous extract from the plant resulted in amelioration of sexual dysfunction, resulted in improved sexual performance compared to diabetic control rats. The treatment also markedly affected sexual behavior of animals as reflected in reduction of mount latency, an increase in mount frequency and enhanced attractability towards female. Superba tuberous powder suspension at high doses (200 mg/kg) in male rats exhibited adverse effects to blood chemistry, haematology, and blood testosterone level. Moreover, there is a dearth of systematic review of scientific literature on experimental evidence generated for medicinal plants useful in treating erectile dysfunction and there is a need for in depth pharmacological evaluation . It is believed to enhance sexual performance by increasing blood flow to the genital area, leading to improved erections. This herb contains saponins, flavonoids, and alkaloids that may help relax the smooth muscles of the penis, allowing for increased blood flow and improved erections. These therapies aim to improve overall well-being, reduce stress, and enhance sexual function. Seeking professional help, such as therapy or counseling, can also provide valuable guidance in managing stress and its effects on sexual health. Managing stress through techniques like meditation, yoga, deep breathing exercises, or mindfulness practices can help reduce anxiety and improve sexual function. Extraction of data from studies was performed by HWL, MSL and THK; TA acted as an arbiter in the data extraction stage.As public awareness of sexual health conditions grows, the demand for dietary supplements to treat these issues is likely to increase.In this process, PDE5 can breakdown cGMP into inactive guanosine-5′-monophosphate (5′-GMP), resulting in an increase in the flow of Ca2+ into smooth muscle cells, thus inhibiting penile erection (Anand Ganapathy et al., 2021).It is believed that Shatavari helps in enhancing the hormonal balance between testosterone and estrogen, which helps maintain reproductive health.Foenum-graecum contain high level polyphenolic flavonoids, which possess reproductive protective effects and antioxidant, antidiabetic and anti-inflammatory functions.These supplements often contain a combination of vitamins, minerals, and herbal extracts that target various aspects of sexual wellness.For individuals seeking natural alternatives to pharmaceutical treatments, there are several remedies that can help improve erectile function.In addition to storing blood, liver can modulate blood volume and maintain the flow of blood.Animal studies have demonstrated that cynomorium can enhance blood plasma testosterone levels, promote sexual maturity, and increase sexual behavior in young male rats. The Benefits of Herbs for Men’s Health This is supported by the Mediterranean diet showing clinical benefit to reduce the deterioration of sexual function in type 2 diabetics in both males and females compared to those on a low-fat diet, where systemic inflammation predicted ED and severity . Two studies by the same group investigated specific nutritional advice and exercise in obese and non-obese male patients with ED over a 2-year duration . Acupuncture treatment was reported to be beneficial in one included study in the results . In healthy Japanese male cohorts without ED, L-arginine improved the IIEF when combined with citrulline and ornithine . L-arginine was found to be used as a sole intervention in one study, where a significant improvement was reported . Assessment of risk of bias in included studies When it comes to maintaining good health, men often face unique challenges. Request an appointment with a Michigan Institute of Urology provider who can advise you about supplements and other treatment options. Learn more about ED, its causes, and treatment options. While the supplements mentioned above may not harm you (except for products sold as “herbal Viagra”), you are urged to consult us before trying them. Ginsenosides, the active ingredient complex of P. ginseng, enhanced NO release from corpus cavernosum endothelial and nerve cells in the corpus cavernosum of New Zealand white male rabbits in vitro (Chen and Lee, 1995). Saponins have been found to be the major active ingredients in P. ginseng, which is responsible for the therapeutic effects. P. ginseng is one of the most famous and most important botanical drugs in traditional Chinese medicine. Sativus increased cGMP levels in Wistar rats. A number of herbal drugs have been validated for their effect on sexual behavior and fertility and can therefore serve as basis for the identification of new chemical leads useful in sexual and erectile dysfunction. All RCTs analyzed in this meta-analysis showed that ginseng was effective in the treatment of erectile dysfunction. Previous studies in animals have shown that these herbs improve erectile function and bolster general well-being, aligning with the clinical outcomes observed in this trial. This condition, affecting middle-aged and older men, is characterised by declining testosterone levels and symptoms such as reduced libido and erectile dysfunction. Research has increasingly more been showing that combining different treatment methods can be more effective than each individual therapeutic approach alone, and it is also true about using Chinese herbs to treat erectile dysfunction. It is unknown exactly why sleep disruption affects sexual function, but researchers think it is due to a combination of stress, lower testosterone levels, and conditions related to both sleep and ED, such as diabetes and high blood pressure. Mental health issues such as persistent stress, anxiety and depression have well documented links with erectile dysfunction. Although it does have some health benefits, ashwagandha doesn’t seem to help erectile dysfunction. Teas contain bioactive compounds, antioxidants, and amino acids that can help improve circulation, testosterone production, stress levels, and heart health—all factors that contribute to erectile strength. Traditional Chinese medicine (TCM) treats impotence by addressing the underlying causes of erectile dysfunction. The researchers found that shilajit increased levels of total testosterone, free testosterone, and dehydroepiandrosterone (DHEAS) compared to the group that received a placebo. By the end of the treatment, the percentage of men with normal testosterone levels went up from 35.5% to 90.8%. Testosterone is a vital hormone that’s involved in both male and female sexual health. Zinc is essential for men on many levels including for healthy testosterone and sperm production. African traditional medicines for erectile dysfunction: elusive dream Therefore, early detection of the pharmacological activities of the reported species against ED is strongly recommended. This, in turn, jeopardizes the extinction of essential medicinal plants which may have stored indispensable compounds that are responsible for addressing the existing global health issues. That is, 50% ethanolic extract of Syzygium aromaticum L., (oral; 100, 250, and 500 mg/kg to rats) improved libido and erection, intromission frequency, mounting behavior, and mating performance 79, 80. The response rates in the red ginseng and placebo arms were used as a basis for calculating the risk ratio, or relative risk (RR) (weighted according to sample size).In this context, traditional medicine practitioners correlate sicknesses and other medical conditions with their possible causes .A large number of studies have been conducted to investigate the effect and mechanism of TCM for treating ED.Ginsenosides, the active ingredient complex of P. ginseng, enhanced NO release from corpus cavernosum endothelial and nerve cells in the corpus cavernosum of New Zealand white male rabbits in vitro (Chen and Lee, 1995).We presented an adapted PRISMA flow diagram showing the process of study selection (Liberati 2009).The aim of this paper was to systematically synthesize literature on the ethnobotany, phytochemistry, bioactivities, and safety of plants used as remedies for managing sexual dysfunction and infertility, and improving fertility and virility in the EAC.In the Shin et al. review, it was concluded that Lepidium meyenii improves sexual desire over a period of at least 6 weeks. Yohimbe has a positive effect on erectile function, it was excluded from the final DS analysis in accordance with the EFSA’s scientific opinion; in Europe, it cannot be used as a food supplement because it increases cardiovascular risk. Furthermore, diosgenin exerts a well-known protective effect on micro-circulation, and therefore, chronically using Tribulus could improve erectile function . The selected articles allowed us to clearly identify effective ingredients (EIs), namely, the substances proposed as having a clinically demonstrated efficacy on the improvement of erectile function. By taking care of themselves physically, mentally, and socially, men can live long and healthy lives. It is important to remember that men’s health is a lifelong journey. Men face a number of unique health challenges, including prostate cancer, heart disease, and mental health conditions. It is important to note that men’s health is not simply the absence of disease, but also the presence of positive factors that contribute to a man’s overall well-being. A total of eight studies out of 543 studies were included in this review. UPMC HealthBeat is the publishing website for UPMC, an integrated health care system based in Pittsburgh. We employ 4,900 physicians, and we are leaders in clinical care, groundbreaking research, and treatment breakthroughs. Headquartered in Pittsburgh, UPMC is a world-renowned health care provider and insurer. Making simple changes in your diet can help you lose weight, lower blood pressure, and have firmer erections. Regarding the assessment of the risk of bias among studies, most reports were judged as having a low (47.8%) or moderate risk of bias (34.8%) (Supplementary file 2). Therefore, 67 records were assessed for their eligibility and inclusion in the study. Information on the reported medicinal plants, such as botanical names (and synonyms), plant family, traditional name(s), growth habit, part(s), and their uses (conditions treated), mode of preparation and administration, isolated pure compounds, and relevant efficacy reports were extracted. Because most studies met parameters 5 to 7 that were similar across them, we relied on parameters 1 to 4 to ascertain the risk of bias status. Herbal extracts have been used by various traditional medicine systems (Chinese, Indian, etc.) for the treatment of ED and the improvement of sexual health.UPMC HealthBeat is the publishing website for UPMC, an integrated health care system based in Pittsburgh.However, this drug often leads to gonadal toxicity, and infertility as a consequence discourages many patients from choosing CP treatment.Other drugs such as Yohimbine, papaverine hydrochloride used under careful medical supervision5, phentolamine, and alprostadil (marketed as Caverject) widen blood vessels.(9) Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels more than two times the upper limit of normal; a creatinine level more than two times the upper limit of normal.We rated one study as having an unclear risk of bias (Choi 1995). Though the authors observed that fenugreek increased anabolic activity resulting in increased muscle mass, it did not affect testosterone levels or testicular architecture at a histologic level. Fenugreek seed extract is reported to improve libido, glucose control, cholesterol levels, and circadian rhythm. Supplemental zinc can both boost serum testosterone levels and improve hypogonadal symptoms in men with zinc-poor diets. Improving your sexual health doesn’t always require medication or supplements. “If you have sexual side effects from medication you can ask your doctor if you can change your medication. Always talk to your doctor about any sexual health problems you may be experiencing. In folk medicine, Turnera diffusa or Damiana of the family Turneraceae is considered as an aphrodisiac. Both the groups exhibited a significant increase in MF, IF, and first sand second ejaculatory latencies. In contrast, the higher dose (3 000 mg/kg, p.o.) reversibly inhibited all the parameters of sexual behavior other than mounting.61,62 Tomentosa and its possible pro-ejaculatory properties in spinal male rats. Carro-Juárez et al. again investigated the pro-sexual effect M. Aqueous extract improved spermatogenesis, which may be due to increased interstitial cell stimulating hormone and testosterone-like effects as well as the induction of nitric oxide synthase . Pruriens to diabetic rats showed significant improvement in sexual behavior, libido and potency, sperm parameters, DSP, and hormonal levels as compared to diabetic rat without extract treatment . Pruriens stimulated sexual function in normal male rats which was observed by increase in mounting frequency, intromission frequency, and ejaculation latency . Ethanol extract treatment for 10 days increased the sexual performance of the treated male rats by extending the duration of coitus and decreasing the refractory period between the different series of copulation . These results suggest that icariin may have a therapeutic effect on erectile dysfunction . Any revisions of the study protocol will be submitted to the ethics committee. This study was approved by the Ethics Committee of the Second Affiliated Hospital, Zhejiang Chinese Medical University, with the identifier 2019-KL (S1 proof of ethics approval). This study conformed to the ethics principles set forth by the Declaration of Helsinki. Foundation provides research funds and evaluates the research results, but is not involved study design, data collection, analysis, the decision to publish or preparation of the manuscript. We would like to thank Dr Chunbao Mo (School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China) for providing professional statistical advice during the design of this study and for providing support in the subsequent data analysis. Excessive Sexual activity Currently, the scientific literature is lacking regarding good-quality studies that can give clinicians clear indications on the efficacy of various active ingredients and which dosages are useful. It is noteworthy that having trouble obtaining or keeping a satisfying erection can also be a signal of underlying health conditions that need a more in-depth investigation, such as endocrine and non-communicable diseases . In about 20% of cases, psychological disturbances are the cause of the disease, while more than 80% of the erectile disorders are organic, both vasculogenic and iatrogenic . Unsatisfactory sexual performance can cause stress, affect self-confidence and contribute to relationship problems, which impact men’s quality of life (QoL) . However, none of the studies carried out provided sufficient evidence to consider these products a first-line therapy. Erectile dysfunction is linked with conditions such as diabetes, sedentary lifestyle, hypertension, obesity, hypercholesterolemia, and smoking 10–12. Through an extensive review conducted in multidisciplinary electronic databases, 171 plant species were identified to have been reported for the management of sexual inappetence (i.e., used as aphrodisiacs, 39.4%), ED (35.9%), infertility (18.7%), and increasing fertility (6.0%). The patients of the included studies had varying degrees of ED. Out of the 22 patients receiving placebo, only one patient showed improvement in complete erection, nine patients showed partial response, and 11 patients showed no response. Subgroup analyses were performed based on studies reporting sole Yohimbine administration and Yohimbine combined with other treatments compared to placebo, as shown in Figure 3. The plants occurred as shrubs (35%), trees (31%), herbs (26%), and climbers (8%) (Figure 3). Synopsis of the most used plant species for the treatment of infertility among men and women in the East African Community. Moreover, they contain phytochemicals such as phenolics, tannins, and alkaloids which are known to have therapeutic effects 50, 51. Species from these botanical families have been reported to have aphrodisiac and fertility potential in ethnobotanical surveys from Ethiopia , Southern Africa , Iran , and India . Plants used in the management of sexual disorders, infertility, and improving sexual virility and fertility in the East African Community. One of the key principles of TCM is the belief that imbalances in the body’s energy can lead to health issues, including impotence.Longifolia increases sexual motivation in sexually naive male rats.Another ingredient that can increase blood flow in sexual organs is ginger.Its potassium content, vital for a healthy cardiovascular system, contributes to improved circulation, critical for sexual health.In some trials only the mean average of all participants was reported or results were presented only with statistical language.These studies have shown that saw palmetto has a benign side effect profile when used to treat urinary symptoms, with the only documented adverse effect being mild gastric distress.It has also been shown to increase sperm concentration and motility and increases energy in the individual by enhancing ATP production by 60% thru oxidative phosphorylation. Ouzir et al. more specifically reported significant spermatotoxic effects and decreased testicular weight in rat, mouse, and rabbit models. Ouzir et al. reported teratogenic, anti-fertility, and neuropathological effects in conjunction with fenugreek consumption in various animal models. Aswar et al. compared the effects of fenugreek extract on testicular development in sexually immature rats. Yang et al. reported that saw palmetto has PDE5 inhibitor properties and noticed an increase in inducible NO synthase mRNA expression on Western blot in rat and rabbit corpus cavernosa muscle tissue. This is used in various Ayurvedic medicines and preparations. Calcium aids in nerve transmission, potentially facilitating the process of sexual arousal. Garlic and honey present potential benefits for men struggling with sexual performance issues. They contain ingredients that stimulate testosterone production either directly or indirectly by stimulating the pituitary gland first. Low testosterone can be fixed with testosterone replacement therapy, or TRT. Piperine is usually used to boost the absorption of other ingredients in testosterone boosters. Saw palmetto mainly acts by blocking the conversion of testosterone to DHT.(13) Male baldness, thinning body hair, or even loss of body hair is often a signal of a testosterone deficiency. As a result, your blood vessels, which carry the blood to your genitals, are dilated, and you get an increase in your sexual desire. It also controls your stress levels and improves your nervous system and entire functioning of your nervous system to have a better sex life. These medicines used in Ayurveda are all natural herbs, thus they are safe for you, having no side effects at all. The sexual health of male is not confined to the matters of controlling and taking prevention from the diseases transmitted sexually. The top 12 herbs for men’s health, including saw palmetto, ashwagandha, and ginseng, offer a diverse range of benefits. The search for natural methods to boost male energy and performance has been a constant theme throughout history. With more clinical data, exact mechanisms of action, safety profile, and drug interaction with other uses of these aphrodisiacs plant materials, treating sexual disorder can become fruitful. The search for natural supplement from medicinal plants is being intensified probably because of its fewer side effects, its ready availability, and less cost. The flavonoids present in active extract may participate in its pro-sexual effect, which is analogous to those produced by yohimbine, suggesting a shared mechanism of action. Diffusa as an aphrodisiac in traditional medicine and suggest possible therapeutic properties of T. A placebo-controlled RCT conducted by Chen et al. in 50 men with ED demonstrated that 31% of men taking a daily 5 gram (g) dose of L-arginine for a 2 week period reported improved erectile function on O’Leary’s sexual function questionnaire. These improved markers of erectile function in animal models suggest that L-arginine improves penile blood flow and prompted further study in human subjects. Medical concerns pertaining to sexual health and erectile dysfunction (ED) are often uncomfortable for men to discuss due to the personal nature of these conditions. Regular physical activity can improve sexual dysfunction and ED through multiple proposed mechanisms that are relevant to ED and cardiovascular disease, including endocrine modulation, increased NO, improved arterial blood pressure, lipoprotein and glucose regulation . In a systematic review investigating Lepidium meyenii on male and female sexual function , an additional two studies were further reported in healthy male cohorts that both showed no significant effect on sexual function compared to placebo . Only a qualified physician in your state can determine if you qualify for and should undertake treatment. All information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. Discuss this information with your own physician or healthcare provider to determine what is right for you. While it can stem from various physical and psychological factors, the quest for natural treatments has led many to explore CBD as a potential remedy. Given the limited body of literature evaluating this ingredient, further work is required to assess its impact on overall sexual function. Zinc, however, is commonly included in dietary supplements targeted at improving overall sexual function. Furthermore, no studies have been conducted on the adverse effects of maca and its side effect profile remains unknown; as such further research is required to determine its role in the management of ED. Four RCTs successfully met the inclusion criteria, of which three discussed effects of maca on healthy men, postmenopausal women, and athletes49–51. Although there is still limited data on maca’s use in human trials, Shin et al. conducted a systematic review of the literature to identify studies evaluating maca’s effects on humans. Cicero et al. evaluated the effect of Maca after oral administration on rat sexual behavior. Gonzales et al. conducted a 12-week double-blind, placebo-controlled, randomized, parallel trial in which active treatment with different doses of Maca Gelatinizada was compared with a placebo. The study revealed for the first time an aphrodisiac activity of L. This is an informational article only where I share my experiences with these herbs with you.|} Erectile dysfunction is a common condition characterized by the inability to achieve or maintain an erection suitable for sexual intercourse. These traditional remedies have been used for centuries and offer holistic solutions for enhancing male potency and improving sexual health. Taking a proactive approach to enhancing male potency and sexual health is crucial for long-term well-being and satisfaction. Terrestris significant improved ED (Roaiah et al., 2016; Kamenov et al., 2017; GamalEl Din et al., 2019), while one prospective, randomized, double-blind, placebo-controlled study did not, which may be because of the limited intervention period (Santos et al., 2014). Two studies of P. ginseng used total ginsenosides and ginsenosides Rk1, Rk3, Rg5, and Rh4. Notably, the majority of studies did not solely study one single identified bioactive substance of plants. In case of missed information in some studies, especially the habitat of the plants, family name, and misspelled scientific name, information was retrieved from the Global Plants Journal of Storage (JSTOR) database . Articles pertaining outside Ethiopia, pharmacological studies, ethnoveterinary studies, and reviewed papers were excluded. The studies written in the English language were only searched. A web-based systematic research literature search strategy was conducted through various electronic databases including PubMed (Medline), Google Scholar, and grey literature to access the relevant studies. The current study was carried out to systematically compile and document the traditional medicinal plants used for the management of ED or impotence in Ethiopia. A study from Andologia in 2012 investigated the effects of Shatavari helps improve sperm count, motility, and semen volume after 3 months of usage.Species from these botanical families have been reported to have aphrodisiac and fertility potential in ethnobotanical surveys from Ethiopia , Southern Africa , Iran , and India .An electric grid was used as an obstruction in the electrical copulation cage in order to determine how much an aversive stimulus the sexually naive male rat for both the treated with E.Whether you’re suffering from erectile dysfunction or just want a performance boost, Chinese herbs get the job done.Thus, further studies are needed to more definitively determine the effects of muira puama alone on erectile function.In this meta-analysis, we included five studies with a high or not fully understood risk of bias (except the paper by de Andre et al.), limiting the weight of the evidence.A dose-dependent decrease of only blood testosterone, but not LH, was significantly different from the control in the rats treated with high doses of plant powder.We rated the certainty of evidence as moderate, after downgrading one level for serious study limitations.In this article, we’ll review the best research-backed herbs for testosterone production. Five studies included men with comorbidities including diabetes, hypertension, and etc (Choi 1999; de Andrade 2007; Ham 2009; Hong 2002a; Kim 2009). The nine included studies investigated 587 men aged from 20 to 70 years old. We attempted to contact all corresponding authors of included trials to obtain additional information on study methods and results, and we received replies from four (Appendix 2). Various animal studies have found that cistanche works to increase male sex hormone production (including testosterone). The researchers found that shilajit helped to increase testosterone levels, sperm count, sperm motility, and FSH levels in 80% of the study participants. Clinical research has found that tongkat ali may be one of the most beneficial herbs for testosterone and sexual health. There is limited additional literature to suggest maca is an effective supplement in ED treatment. Studies on the usage of maca for sexual enhancement are limited, and to date there is no clearly understood mechanism of action. Furthermore, though no definitive studies have been conducted on the side effect profile of tribulus, case reports of renal failure and liver failure have been documented following its consumption45,46. Santos et al. found no improvement in ED symptoms or IIEF scores in men treated with tribulus when compared to a placebo in an RCT . This substance may also combat numerous health-oriented ailments. It is a sticky, tar-like, and black substance that treats various physical conditions, thereby improving your overall health. From improving the testosterone level to higher sperm production, it does it all. For instance, it may be an obvious way of masking the toxicity of herbal remedies or hiding the secrecy of the formularies 62, 63. A striking example of using adjuvants is from Tanzania where roots of Polygala aphrodisiaca are cooked with a young cock while Duosperma kilimandscharicum leaf and root decoction are taken with goat blood or goat meat soup as an aphrodisiac . This review noted a tendency of including more than one plant part and adjuvants in herbal remedies. Figure 4 illustrates which plant organs are widely used in preparation of the herbal remedies, that is, roots (44.9%), leaves (21.8%), and stem and root barks (16.7%). Erectile Dysfunction - Randomized Controlled Trials (PubMed®) It is not intended to substitute for the medical expertise and advice of your health care provider(s). NCCIH and the National Institutes of Health (NIH) provide tools to help you understand the basics and terminology of scientific research so you can make well-informed decisions about your health. It has been used basically for treating ringworm, swelling of women’s genitals and male impotence. Moreover, the administration of EGb761 was able to enhance the noncontact erection, a penile erection initiated by brain centers, in male rats by increasing the dopamine contents in some parts of brain (14,15). It was reported that EGb761 preserved the neural nitric oxide synthase (nNOS)-positive nerve fibers after cavernous nerve injury in rats (13). Ginkgo Bilobae extract was shown to have vasoprotective and neuroprotective effects. Ligusticum chuanxiong Hort is planted primarily in southwestern China, which is usually used to promote blood flow and alleviate pain. Despite considerable efforts to conduct a comprehensive search, we only identified and included nine eligible studies. We consistently downgraded the certainty of the evidence for study limitations. We were unable to perform sensitivity analysis because there were no studies with an overall low risk of bias. We included 9 RCTs, involving 587 participants, which all compared ginseng versus placebo. One of the key advantages of integrating Chinese medicine with conventional treatments is the potential for a comprehensive approach. Taking a holistic approach to male health is crucial for overall well-being and longevity. Apart from Chinese medicine, there are other alternative treatments that may help with impotence. The new drug used for the treatment of erectile dysfunction, and sildenafil acts by potentiating the effect of NO by inhibiting the specific enzyme phosphodiesterase-V that terminates the action of NO generated cGMP in the penile vasculature . The skepticism towards the concept of aphrodisiac is not unjustified, although a systematic evaluation and compilation of scientific information may provide a basis for the evidence-based utilization of herbal drugs for treatment of sexual dysfunction in general. The strength of this work is related to the fact that the meta-analysis allowed us to clarify that some herbal extracts and nutrients, such as Ginseng, Tribulus and Arginine, are able to improve male sexual function. The saponins fraction was suggested to positively influence testosterone production and improve libido and erectile function . Herbal remedies and natural supplements have gained popularity as potential solutions for male enhancement. Vata dosha is the main energetic force that helps to keep all body functions in normal condition. Apana vayu is the reason for male erection and ejaculation.… Best Dry Fruits and Nuts for Erectile Dysfunction or ED or Impotence This herb can improve sexual health by toning muscles of male organ and increasing stamina. Kaunch has already been recognized as an aphrodisiac and it releases a high volume of testosterone, which is necessary to keep sexual health sound and functional. Now a day, many men have already reported for diversified sexual problems and dysfunctions researchers are also trying to get over these dysfunctions permanently. Premature ejaculation, reduced sex drives, semen infection, erectile dysfunction, and infertility are a few of the most common sex issues faced by men these days. It is recognized for its potential to enhance testosterone levels, promoting better sexual health and muscle strength in men. They also evaluated the effect extract on males with anesthetization of the genital area and on sexual behavior of sexually inactive male rats (noncopulators).European herbalists have found that Catuaba may have aphrodisiac properties and can be used to combat sexual weakness.These products may not have evidence to back up their claims, and they could also lead to unwanted side effects.In this study, patients were required to orally intake Tribestan (Sopharma AD), an botanical medicinal product of Bulgarian origin, standardized with respect to furostanol saponins, calculated against protodioscin.There was also a significant increase in serum testosterone concentrations in all the groups in a manner suggestive of dose-dependence.Erectile dysfunction has remained as one of the major global health issues.Green World Herbal Supplement Store in Nigeria offers natural health products, herbal remedies, and nutritional supplements for wellness, vitality, and a healthier lifestyle.However, there were only 30 study subjects enrolled without control group. If you frequently have problems getting or keeping an erection, you may have erectile dysfunction (ED). Drewes et al.20,21 have shown, in a rabbitexperimental model, the plausible therapeutic beneficial effects of bioactivecompounds of E kraussianum in the management of erectiledysfunction. The various communities and societies on the continent, in addition to‘owning’ traditional remedies for ailments such as hypertension, diabetes mellitus,arthritis and other chronic conditions, also ‘own’ remedies for socio-culturaldiseases such as erectile dysfunction. The mean half-life for bothsildenafil and vardenafil is about four hours, whereas the mean half-life oftadalafil is 17½ hours, and tadalafil has also been shown to improve erectiledysfunction for up to 36 hours post dosing.12,16 The medical ethnobotanical indigenous knowledge were collected by visiting traditional healers and documenting the medicinal plants used and other socio-cultural aspects allied with sexual impotence and erectile dysfunction. Thus, some diseases such as sexual impotence and erectile dysfunction that deserve mention are regarded as petty though important in economic productivity, family stability and sexually transmitted diseases control including HIV/AIDS. Some of the herbs that we've mentioned are often used to treat erectile dysfunction, like pine bark extract, yohimbe, and horny goat weed. Anti-psychotic drugs often cause sexual dysfunction in patients with schizophrenia, this can be as high as 50% of male patients (17). It has remained one of the major global health issues which is usually attributed to age, diabetes mellitus, smoking, cardiovascular diseases, kidney disease, previous operations, psychological factors, and drugs 2, 3. Accordingly, fifty-four published articles and thesis papers were finally included in this study. Electronic databases of PubMed (Medline), Google Scholar, and grey literature were employed to access the studies. Always consult with a physician before taking any of these herbs to make sure they are safe and will work for you. Some of the most well-documented herbs are Ashwagandha, Maca root, Tongkat Ali, and, of course, Shatavari. A total of 109 patients were recruited (Ismail et al., 2012). The duration of this study spanned a period of 3 months. Forty-five patients were recruited, and 8 dropped out (Leitao et al., 2021).