The conventional wisdom, as spelled out by the American Urological Association, is that a healthy level is higher than 300 ng/dL; some experts argue that “low” is a little lower and starts at 264 ng/dL. Testosterone levels, which are measured in nanograms per deciliter of blood, naturally wane as we age. And in the last couple years, that includes testosterone, which is easier to get than ever before. The testes respond to pituitary hormones LH and FSH which are stimulated by GNRH from the hypothalamus. More studies with longer follow-up are needed to evaluate the kinetics of TT in these patients. Finally, CC represents a good alternative to TRT with the advantage of not blocking HPT axis, but taking into account our results and previous series (23, 25), it should be discussed with the patient that treatment will be permanent in most cases. Over time, the testicles may shrink and fertility may decrease. Blood tests are important to check red blood cell levels. This can make the blood thicker than normal and increase the risk of blood clots. Embracing a holistic approach to health by incorporating these practices can not only enhance testosterone levels but also improve overall quality of life. Additionally, a balanced diet rich in nutrients like zinc, vitamin D, and healthy fats is crucial for supporting healthy testosterone levels. In addition to its crucial role in male health, testosterone also has effects on women’s bodies, albeit in smaller amounts. Testosterone replacement therapy has significantly increased in the last decade (16), however, everyday practice concerns are multiple (17). Previous series have demonstrated that Clomiphene Citrate (CC) is an effective treatment to increase Total Testosterone (TT) in Late Onset Hypogonadism (LOH) patients. However, up until now, data supporting the efficacy of clomiphene citrate and tamoxifen on hypogonadal symptoms are insufficient. Estrogenic and antiestrogenic effects of enclomiphene and zuclomiphene on gonadotropin secretion by ovine pituitary cells in culture. When in treatment, the body stops making its own natural testosterone. Since you continue to produce your own natural testosterone, if you decide to stop treatment your body will most likely return to the level it was before treatment. Enclomiphene citrate is the purified isomer of Clomid (Clomiphene Citrate), which has been FDA approved since 1967 for fertility in women, and has been commonly used off-label in men. Columbia University Irving Medical Center In most cases, clomiphene works well on its own to boost testosterone levels in men with ASIH, according to Staheli. One instance where clomiphene is a better option for PCT than testosterone replacement therapy? TRT gives hormone levels a direct boost and is more effective at treating low testosterone than clomiphene, according to a 2017 study (6). “It tricks your brain into thinking that your estrogen and, by proxy, testosterone levels are lower than they actually are,” Masterson says. All men had two separate values of early morning total serum testosterone During the same study period, 52 eugonadal men who were not receiving TST or CC were included as a control group for comparison. The standard ADAM questionnaire consists of ten “yes or no” questions concerning symptoms of androgen deficiency (range 0–10). After approval from the Institutional Review Board, we assessed hypogonadal symptoms using the ADAM and qADAM questionnaire. CC remains a viable treatment modality for hypogonadal men but its adverse effect on libido warrant further study. Symptoms were evaluated using the androgen deficiency in aging male (ADAM) and quantitative ADAM (qADAM) questionnaires. Also, the lower the testosterone level, the longer it may take to see the benefits of Clomid versus traditional testosterone therapy. Once testosterone has been produced it naturally converts to some estrogen. Originally it was used to increase ovulation and improve fertility in women. Backed by research and thoroughly studied, it became the preferred treatment option for men diagnosed with low testosterone. Hypogonadal symptoms are subjective, which can complicate patient diagnosis and identify success with treatment. This medication is often used to treat female infertility by inducing ovulation. This is where Clomid comes in as an alternative for testosterone therapy. With the advancements in medical science, treatments for men with low testosterone now exist. Austin Urology Institute is home to one of Austin’s best urologists, Dr. Shaw, who is an expert in general urology as well as male sexual health. Signs of Male Infertility Over the last few decades, fertility treatments have made a life-changing difference for couples and individuals hoping to start a family. If you’ve not been feeling your best, but can’t exactly pinpoint why, it might be time to get your hormone levels checked! Men with secondary hypogonadism are most likely the best candidates for Clomid since the condition is an issue with the brain/pituitary gland rather than the testes’ ability to produce testosterone. We look at your current symptoms, medical history, test results, and lifestyle choices in order to create a personalized treatment plan that will produce the most effective results. We are seeing low T in younger and younger men, and fertility is something patients often ask about. UCSF has helped patients become parents with donor eggs since 1991. It is for educational purposes only and is not intended to replace the advice of your doctor or other health care provider. This property of the drug is helpful in patients expected to respond poorly. Therefore, it is used in preparation for cycles of treatment with ovulation induction drugs, such as exogenous hMG-LH/FSH and/or FSH. Low testosterone levels can negatively impact male fertility and overall well-being. Clomid stimulates the body to produce natural testosterone, whereas testosterone replacement therapy directly adds testosterone to the body, which can suppress natural production. This increase naturally encourages the body to produce testosterone and, in many cases, improves sperm production. Clomid binds to receptors in the brain in both men and women to increase FSH and LH production. With the right monitoring, lifestyle habits, and medical guidance, it is possible to feel better, strengthen sperm health, and stay aligned with your TTC goals. These small steps support sperm quality and overall health, which can make TTC feel more manageable. How Does Clomid Compare to Traditional Testosterone Therapy? This natural approach is also why some men find Clomid has fewer side effects compared to TRT, potentially avoiding issues like testicular shrinkage or an increased risk of blood clots. As we learn more about men’s health and hormonal balance, treatments like Clomid are getting a closer look. They can assess your individual situation, discuss all potential treatments, and help you understand if Clomid is a good fit for your health goals. If you’ve been wondering whether Clomid could be an option for addressing low testosterone, having a clear conversation with a healthcare professional is key. Low testosterone levels can manifest in numerous ways including fatigue, diminished sex drive, difficulties with concentration, depression, and physical changes like body fat increase and decreased muscle mass. But Clomid does raise testosterone, and with the help of your Alpha low testosterone doctor, you will see many of the same results as you could get from testosterone replacement therapy and increased fertility. There are several benefits of taking testosterone replacement therapy as a low testosterone treatment, including increased energy, sexual performance, and cognizant functioning. A full hormone test should be done to understand the cause of low testosterone. Before starting any treatment, it is important to talk with a healthcare provider. Some doctors also check sperm counts when fertility is a concern. Regular blood tests can help check hormone levels and catch problems early. Potential Side Effects and Precautions You need your body’s testes to produce testosterone naturally to maintain testis size and sperm count.Some women take clomiphene citrate as part of fertility treatment like in vitro fertilization (IVF) or intrauterine insemination (IUI), but the medication can also be taken on its own.Patients were asked if they experienced any side effects related to the use of CC and if they experienced any improvement in their sexual profile.Also no specific questionnaire was applied to the patients regarding LOH symptoms, however, these questionnaires are not recommended by the guidelines since their specificity is low and are not effective for case finding (5).It is generally considered safe and has been shown to effectively raise testosterone levels and alleviate low T symptoms.Similarly, clomiphene also won’t work for men who have a damaged or non-functional pituitary gland.This leads to increased secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulates the testes to produce more testosterone and sperm.Many factors can determine the effectiveness of a TRT protocol such as original testosterone levels, genetics, age, lifestyle choices, other medication etc. Having said that, it seems that Clomid is the best replacement for hCG in many doctors’ opinions which is why it is gaining popularity.“All estrogen in the human body starts from testosterone, so men who have higher testosterone levels also have higher estrogen levels,” Barnett says. On the other hand, traditional testosterone replacement therapies (TRTs) can interfere with this balance, sometimes reducing sperm production and causing testicular shrinkage. Unlike TRT, which replaces your testosterone synthetically, enclomiphene increases your natural testosterone production. Increased testosterone levels are achieved while maintaining sperm concentration (unlike TRT). If/when therapy ends their body's natural testosterone production most likely will not fully recover. Enclomiphene, the active ingredient in Testosterone Protocol, blocks estrogen receptors and treats long-term hypogonadism (low testosterone). Since testosterone is the primary hormone required to make sperm, a higher concentration in the body means more sperm. At Male Excel, we only prescribe hormone replacement therapy to men over 38 to protect the fertility of younger men. However, testosterone replacement therapy isn't usually suitable for guys under 38 because it can damage fertility. Clomid can benefit men with low testosterone or infertility, as it promotes the natural production of testosterone and sperm in the testes. Roman's system provides you with its testosterone booster on a subscription basis for $35/month billed monthly or $29/month billed quarterly. When we evaluate the cost of a testosterone booster, we consider its price and any potential avenues for savings, including bulk and subscription discounts. Some testosterone boosters combine a handful of well-researched ingredients with lesser-known botanicals that have plenty of anecdotal history but little scientific rigor to back them up. As you can see, the only product that comes close to matching Innerbody Labs' combination of ingredients and clinically relevant doses is Nugenix, but its Total-T MAXX costs nearly $100 more per bottle. Here’s a quick look at how ingredient bills compare among the top testosterone boosters on the market. Drinking alcohol with this medication can increase the risk of these side effects. It works by helping your body release an egg (ovulation), which increases the chance of pregnancy. Clomiphene is a medication that increases your chances of pregnancy by helping your body produce an egg (ovulation). Clomid blocks the estrogen receptors of the body preventing them from binding to estrogen. How do you bring your sex hormone levels to their normal rate by using Clomiphene? Their mode of action can vary depending on the target tissue, either mimicking the effects of estrogen (agonist) or blocking them (antagonist).One RCT demonstrated that clomiphene significantly increased the levels of total testosterone, free testosterone, LH, FSH, estradiol, and sex hormone-binding globulin (SHBG), as well as showing improvements in ADAM score .One of the biggest concerns is that it can lower sperm production and reduce fertility.Studies have shown that individuals with adequate testosterone levels tend to experience improved mood, increased motivation, enhanced cognitive function, and a heightened sense of well-being overall.An increase was also seen in free testosterone, luteinizing hormone, follicle stimulating hormone, sex hormone-binding globulin and estradiol.It’s especially suitable for those with secondary hypogonadism, where the issue lies in hormonal signaling rather than testicular failure.Clomiphene doesn't contain any hormones, but it signals to your brain that there isn't enough testosterone in your system, leading to an increase in production.By adding Clomid, the brain keeps telling the body to make its own hormones. While the literature is robust with improvement of hormone levels, there is a lack of data showing clinical improvement. It is unclear at this point whether higher increases in testosterone via aromatase inhibition would help counteract the negative consequences of lower estradiol. Decreased seminal T/E levels have been shown to be a good indicator for identifying the absence of sperm (20). The conversion of testosterone to estradiol in the gonads has been predicted to be the cause of an increased testosterone/estradiol (T/E) ratio. Side effects that are similar to estrogenic side effects but which you need to tackle differently to how you deal with estrogen-related adverse effects. DHT and testosterone-based steroids are to blame here, but the mitigation methods are slightly different from how you manage the other side effects I’ve mentioned. Of all steroid side effects, this can undoubtedly be one of the most severe risks to your health if allowed to get out of control35. When you reduce your circulating levels of DHT too far, you’ll experience adverse effects (low libido, fatigue, depression, poor muscle mass). You won’t get any symptoms of low DHT because your levels are not suppressed when using RU-58841. That’s why both Clomid and TRT should only be used under medical supervision, with regular blood tests to check hormone levels, cholesterol, blood pressure, and red blood cell count. Restoring healthy levels — especially in combination with regular exercise and good nutrition — can help reduce these risks. Low levels can lead to weaker bones and poor metabolic health. PPD is looking for overall healthy adult males ages years old to participate in a research study at our Austin clinic. In men, Clomid blocks oestrogen receptors in the hypothalamus, a key part of the brain involved in hormone regulation. This mechanism makes it valuable not only for women managing ovulation issues but also for men seeking to improve testosterone production. It works by interfering with how oestrogen interacts with certain receptors in the body. When considering the safe and effective use of Clomid and testosterone, it is crucial to delve into the nuances of dosage and administration. Common side effects of Clomid include hot flashes, mood swings, headaches, and gastrointestinal disturbances. Moreover, the synergistic effect of Clomid and testosterone can lead to improved recovery times after intense physical activity. We identified patients with 3, 6, 9, and 12 month follow-up data for TT and 3, 6, and 9 month follow-up SA. Missing a dose occasionally may not have a significant impact, but it’s essential to maintain a regular dosing schedule to optimize the treatment’s effectiveness. If you have any concerns or questions about missed doses, it’s best to consult with your healthcare professional for guidance. Limited Guidance on Combination Therapy By adding Clomid, the brain keeps telling the body to make its own hormones. Doctors sometimes use these two treatments together, but it depends on the person’s health needs and goals. Clomid works by helping the body make more of its own testosterone, while TRT provides testosterone from outside the body. Finding what works for you – whether it’s yoga, spending time in nature, or listening to music – can significantly improve your overall health and support your body’s balance while you’re on Clomid. It’s important to remember that your emotional well-being is just as important as your physical health, especially during treatment. Let’s be real, dealing with symptoms of low testosterone can be stressful, and that stress can sometimes feel like an extra weight on your shoulders. In a comparison between CC (25mg/day) and anastrozol (1mg/day), Helo et al. treated 26 hypogonadal and infertile men for 12 weeks, observed an increase in TT levels in both groups, but more significant with CC (27). The result showed that CC serves as an alternative to the use of exogenous testosterone (gel), with few side effects and a much lower cost (15). TT increased from mean pre-treatment value of 277ng/dL to a mean value of 573ng/dL after. The authors observed a similar increase in TT levels in both treated groups, as well as improvement of clinical parameters (25). While some men may experience faster testosterone increases on Clomid therapy, research indicates it generally takes 2-3 months to maximize testosterone levels and see the full benefits in relieving symptoms of low testosterone. Clomid takes 2-3 months to increase testosterone levels in men because it works indirectly by stimulating the pituitary gland to release hormones that in turn increase natural testosterone production. These treatments add to the armamentarium of andrologists for treating male hypogonadism when there are concerns about exogenous testosterone therapy such as the scenario in the case of a hypogonadal male seeking to preserve spermatogenic potential. This can lead to problems such as infertility, low sex drive, and bone loss. These patches are typically applied to the arm or shoulder once or twice a day, and they deliver a steady stream of testosterone into the bloodstream. It should not be applied to the genitals (cisgender men) or breasts (for transgender males transitioning from female to male). While Clomid is a promising treatment, it’s not the only option on the table. The side effects we discussed earlier are real, but they’re also manageable with proper medical oversight. However, as with any treatment, the risks must be weighed against the rewards. If any of these scenarios sound familiar, Clomid could be the treatment you’ve been searching for. Your health and comfort should always come first. But is testosterone replacement therapy your only option?At no point were there improvements in semen volume or sperm motility (Fig. 1C, 1D).Your doctor will work with you to determine the best plan, which includes regular monitoring to see how you’re progressing and to decide on the appropriate length of treatment for your needs.Commonly used aromatizing steroids like Testosterone and Dianabol can quickly raise your estrogen levels to bring on side effects like gynecomastia and water retention.It is essential to discuss any side effects experienced while taking Clomid with a healthcare provider to determine the best course of action and ensure the well-being of the patient.Men with low testosterone have a 33% higher risk of death from any cause than men with normal testosterone levels regardless of age, physical activity, or lifestyle.The American Urological Association and European Association of Urology guidelines recommend CC as an off-label treatment option, mainly in men with low T who have interest in fertility and in men with T deficiency who have infertility (for pathway, see Figure 1).9 Patients who have expressed concerns about testicular atrophy observed with exogenous T during T therapy counseling are also excellent candidates for CC.Clomid, comprising both Enclomiphene and Zuclomiphene, has been utilized in TRT for a significant time. Clomiphene citrate, also known by the brand name Clomid, is a drug that belongs to a group of medications called selective estrogen receptor modulators (SERMs). Enlarged veins in the scrotum, known as varicocele, can be a sign of low fertility. Impaired hormone balance can lead to other issues that deviate from a person’s norm. This, in turn, stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland, which promotes testicular function and testosterone production. At BrandeisMD, we understand the importance of addressing hormonal imbalances in men, and Clomid represents a promising option for those experiencing low testosterone levels. It works by stimulating the release of gonadotropins, which are hormones that help to regulate the production of testosterone. However, occasionally you need to run PCT for two months to truly restore your natural production levels (it depends on how aggressive the performance-enhancing drug you used was). To achieve outcomes comparable to those of half the dose of Clomid, you would need to take two times as much Nolvadex, but you still wouldn't experience increased LH and FSH production. Despite both being taken within similar dosage ranges, Nolvadex will result in far lower amounts of testosterone rebound at those same levels. Clomid is a medication that is commonly used to treat infertility in females. It's best to fully evaluate your health and develop a personalized treatment plan. This is particularly important for men who wish to preserve their fertility. Optimal results often require a comprehensive approach that includes lifestyle modifications, such as regular exercise, a healthy diet, stress management, and adequate sleep. It’s important to have realistic expectations about the outcomes of therapy. DHT is a potent androgen that can contribute to male pattern baldness in genetically susceptible individuals. The results of the EMAS in 2736 men (mean age 58.4 years), showed that weight loss of minimal 5% of body weight in obese men resulted in a significant increase in total testosterone levels. Therefore, the European Male Aging Study (EMAS) group suggests that only ageing men with concomitantly low total and free serum testosterone levels, and at least three sexual symptoms should be diagnosed with late-onset hypogonadism 10,11. Late-onset hypogonadism is a condition in ageing men that is characterized by low serum testosterone levels and sexual signs or symptoms. Central hypogonadism is a clinical condition, characterized by sexual symptoms and low serum testosterone levels, due to an impaired function of the hypothalamus or pituitary gland. In case of a pituitary prolactinoma, treatment with dopamine agonists can be indicated and can result in normalization of testosterone levels and improvement of semen quality and libido 1,3,28,29,30. Only a weight loss of minimal 15% had significant effects on free testosterone levels. The use of clomiphene citrate, tamoxifen and AIs is off-label in male hypogonadism. A full hormone test is needed before starting any treatment. A doctor can order a semen analysis to measure sperm count before starting any treatment. Some treatments for low testosterone can lower a man’s ability to father children. Testosterone therapy can lead to acne, hair loss, mood changes, and increased red blood cell count. A study found that men with obesity-related hypogonadism who took Clomid showed improvements in lean body mass, including more muscle mass. The researchers concluded that taking Clomid is a safe therapy for supporting sperm function in infertile men. Monitoring key health indicators and discussing any concerns or changes experienced during treatment can help ensure the safe and effective use of Clomid for its intended purpose. It is crucial for individuals considering extended Clomid use to weigh the benefits against the risks and to consult with a healthcare provider regularly to monitor any potential adverse effects. Prolonged use of Clomid may have potential implications for cardiovascular health and fertility that users should be aware of. It is a popular fertility treatment due to its ability to increase spermatogenesis in males as well as increase serum testosterone levels. Low dosing of enclomiphene is effective in raising serum testosterone levels and helping balance the testosterone/estrogen ratio in males who have hypogonadism.Clomid stimulates the androgen production pathway which is why it can be an effective medication for TRT. While Clomid (clomiphene citrate) is well-known as a medication for female infertility, it can also be prescribed off-label for men dealing with infertility or low testosterone levels (male hypogonadism). Unlike testosterone replacement therapy, which can suppress the body’s natural production of testosterone over time, clomiphene citrate stimulates the body’s own production of the hormone. What are the causes of male infertility? In fact, male infertility may be a contributing factor in about 50% of cases.1 If so, you might be dealing with male infertility. But does clomiphene really work for men, and is it the right choice for those struggling with low T or fertility issues? Compare 8 of the best online testosterone therapy services available in 2025. Variability in levels was obviated by the random nature of the draw and the number of patients surveyed. These men underwent hormone estimation and were treated for benign urological conditions such as erectile dysfunction and lower urinary tract symptoms. QADAM scores range from 10 to 50, and higher scores indicate less severe hypogonadal symptoms; however, no particular threshold score is known to accurately diagnose hypogonadism. Our cross-sectional analysis was unable to address whether testosterone supplementation and CC would improve specific hypogonadal symptoms. Most Dangerous Anabolic Steroids Are you curious about some alternatives to testosterone replacement therapy? At Gameday Men's Health, we understand the importance of personalized care when it comes to testosterone replacement therapy. Choosing between Clomid and Enclomiphene for TRT depends on several factors, including your individual health status, treatment goals, side effect concerns, and personal preferences. Factors such as the underlying cause of low testosterone, age, and overall health can influence the treatment’s success. Clomid can increase endogenous testosterone production, potentially reducing the need for high doses of exogenous testosterone. In men, this results in enhanced endogenous testosterone production and improved sperm count. However, the medicine didn't lower the men's sperm counts because testosterone production in the testes was never compromised. Many primary care physicians do not know about this effect, however, and they readily prescribe testosterone to male patients who have low testosterone and also wish to have a child, said Ross, who wrote an editorial accompanying the new study in the journal. Understanding the nuances of testosterone replacement therapy (TRT) can be daunting, especially when exploring alternatives.Signals from the brain stop test production in the testicles.However, some small studies are available that report the side effects of clomiphene citrate and tamoxifen in men.These men underwent hormone estimation and were treated for benign urological conditions such as erectile dysfunction and lower urinary tract symptoms.For men who want to address symptoms like low energy, decreased libido, or poor concentration without compromising long-term reproductive health, Clomid represents a rarely discussed but clinically effective option.CC has been shown consistently to improve both TT and symptoms of hypogonadism 10,11 with a limited side effect profile . Testosterone levels increased in all groups at all time points, with a final mean value of 5.17 ± 1.77 nmol/L (223% increase) with no statistically significant difference among the groups. At Vital Men Health Center, we specialize in personalized treatments to optimize your health and well-being. Importantly, Clomid may be preferred in cases where long-term hormonal dependency is a concern, making it a viable, reversible first step in managing testosterone-related symptoms. Additionally, men who have experienced suppressed sperm counts due to TRT and wish to restore fertility may use Clomid as part of a “restart” protocol. For one, just because Clomid is not approved as a treatment for men with low testosterone does not mean that it is not effective. Although clomiphene citrate is not a steroid, it is still a prescription medication. Clomid works by shutting down estrogen’s communication with the pituitary gland, forcing it to produce more LH and continue making testosterone. Moreover, the role of TRT to treat men with functional or late-onset hypogonadism remains controversial because of unclear indications and potential side effects 1,9. It suppresses spermatogenesis, and thus, cannot be used in patients with a desire to have children in the near future. In functional central hypogonadism, the HPG axis is structurally intact, but gonadotropin production is suppressed. If you’re considering Clomid as part of your treatment plan, consult a healthcare provider to determine if it’s right for you. Clomid stands out as a middle-ground solution, offering the benefits of hormonal treatment without the fertility concerns of TRT. By addressing testosterone deficiency naturally, Clomid offers a more holistic approach to managing symptoms. This external supply can lead to the underutilization of your own production facility (the testicles), causing it to shut down due to inactivity. While considering your treatment options, it’s also important to factor in the costs involved. Typically, the normal testosterone range for young men lies between 600 and 900 ng/dL, whereas for older men, it is between 500 and 800 ng/dL. A testosterone level below 300 ng/dL in the blood is considered significantly low, a benchmark deemed as a “reasonable cut-off.” These include maintaining a healthy weight, regular exercise, stress management, quality sleep, balanced nutrition, and avoiding excessive alcohol consumption.Variability in levels was obviated by the random nature of the draw and the number of patients surveyed.However, it was found that there was an alternative to “replacing testosterone” which resulted in similar results but was a more “natural” method.If you’ve been diagnosed with low testosterone, you’re not alone and you’re not without options.Clomiphene citrate helps to increase levels of testosterone in the body, which can improve these symptoms.Estradiol was significantly increased following clomiphene citrate treatment.In conclusion, Clomid can be a viable option for men with low testosterone, offering a potential alternative to testosterone replacement therapy.Once the FDA approves a drug, healthcare providers can typically prescribe the drug for an unapproved use when they judge that it is medically appropriate for their patient.It’s important that you be informed of the potential side effects before starting any medication and discuss with your doctor if you have any concerns. Yes, clomiphene citrate can be used as a long-term treatment option for men with low testosterone levels. The time it takes for clomiphene citrate to increase testosterone levels can vary from person to person. By stimulating your body’s natural production of gonadotropins and testosterone, clomiphene citrate helps maintain testicular function and sperm production. If you are actively trying to conceive or wish to preserve your fertility potential for the future, clomiphene citrate may be a more appropriate choice than traditional testosterone replacement therapy. Determining whether clomiphene citrate is the right choice for treating your low testosterone levels requires a comprehensive evaluation by a qualified healthcare provider. This condition causes the testes to overheat, which can negatively affect sperm production. Testicles that are unusually small or firm may indicate problems with sperm production. Unexplained weight gain—especially when accompanied by other symptoms—may indicate a hormonal imbalance and potential infertility. In some cases, the cause of male infertility remains unidentified, known as “idiopathic infertility.”1 Your healthcare provider may order this test to evaluate sperm count, shape, and movement. Clomid acts on the hypothalamus, a region of the brain that regulates the production of FSH and LH. These endocrine changes negatively affect libido, sexual function, mood, behavior, lean body mass, and bone density. Such content is not intended to replace an evaluation with a qualified healthcare professional of your choosing and is not intended as medical advice. Learn which TRT method fits your goals and how Gameday Men’s Health creates personalized treatment plans. Compare oral testosterone vs injections to understand effectiveness, convenience, results, and safety. After completing their steroid therapy, what athletes generally do is to start taking supplements so that their hormones get balanced. Though steroid does give the results that bodybuilders desire, it also comes with its own share of side effects, and to balance the side-effects most bodybuilders depends on Clomid. We do not routinely prescribe any over-the-counter supplements to men transitioning off testosterone therapy. We counsel men who are either actively pursuing pregnancy or have fertility as a near-term goal to avoid all exogenous testosterone. Graham Simpson, M.D., one of the cofounders, has himself been on testosterone therapy for 27 years; he’s 72, but doesn’t look much older than 50. If you’re as interested in health span and longevity medicine as you are in testosterone, then Opt Health is for you. It’s usually at this mark that Blokes consults with you to figure out if you’re on the right form of testosterone therapy or drug. In one 2018 study of men at infertility clinics in Turkey, cryptozoospermia was found in 27.2% of male-factor infertility cases.3 In males, potential causes for infertility include low or no sperm count, poor sperm motility, and sexual or ejaculatory dysfunction. Male fertility relies on a complex system of processes, including the ability to make healthy sperm, obtain an erection, and ejaculate to ensure the sperm reaches the egg. Although an infertility diagnosis can be discouraging, a number of sperm-boosting drugs and supplements can help improve male fertility issues. If the patient has hypogonadotropic hypogonadism and desires fertility or if he is adolescent, instead of TRT, gonadotropins can be started to stimulate testicular growth and spermatogenesis. Contact Boston IVF today to schedule a consultation and learn if Clomid is the right fertility treatment for you. If you're searching for affordable fertility treatments nearby, or an IVF clinic nearby, Boston IVF is here to support you every step of the way. At Boston IVF, we provide expert fertility care and personalized treatment plans tailored to your unique needs. Clomid side effects can sometimes mimic early pregnancy symptoms. Clomid stimulates ovulation by blocking estrogen receptors in the hypothalamus—a gland in the brain that regulates reproductive hormones. Clomid is the brand name for a medicine called clomiphene citrate.This combination can further stimulate the testicles to produce testosterone and sperm.Incorporating stress-reducing activities into your daily routine, such as meditation, yoga, or spending time in nature, can help support healthy testosterone levels.In normal physiology, the gonadotropins are released from the pituitary and stimulate the testes to produce testosterone.Taking Clomid and testosterone together is not right for everyone.It has been shown to increase overall testosterone levels in men who take it that have been diagnosed with clinically low T.Clomid (Clomiphene Citrate) is an oral medication that stimulates your body’s natural testosterone production by acting on the hypothalamus and pituitary gland.This is accomplished through their functionality as Selective Estrogen Receptor Modulators (SERMs), which ultimately induce heightened testosterone production in the testes. Enclomiphene citrate works by stimulating the hypothalamus and pituitary gland to increase the natural production of testosterone and treats male Hypogonadism. In females who are using clomiphene for fertility treatment, a variety of side effects are commonly reported in connection with hormone stimulation and the reproductive system. A 2014 study published in the Journal of Urology found no difference in testosterone levels between men on clomiphene alone compared to those on testosterone replacement therapy. In young men with hypogonadism, with a mean age of 29 years, clomiphene treatment resulted in significant increases in total testosterone, free testosterone, LH, FSH, and estradiol levels. Due to this reason, some bodybuilders prefer to use this compound during their steroid cycle. Estrogen in the pituitary gland hinders the natural production of Follicle Stimulating Hormone – FSH and Luteinizing Hormone – LH. This is how Clomid works inside the pituitary gland, blocking estrogen receptors there. While generally well-tolerated, Clomid is not without side effects. Clomid works by blocking estrogen receptors in the brain, specifically in the hypothalamus. It was originally approved by the FDA to treat infertility in women by stimulating ovulation. Clomid is a selective estrogen receptor modulator (SERM). Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. That could be an indication of high estrogen and should be treated. One of the most common side effects is pain or swelling at the injection site. At the same time, men can maintain their normal sexual functions with an internal hCG testosterone booster leading the way. As with any medical treatment, there are potential side effects to be aware of.By doing this, it tricks the body into thinking oestrogen levels are low.Clomid can be an effective alternative to testosterone replacement therapy for the treatment of low testosterone, and it can have fewer side effects.If you’re as interested in health span and longevity medicine as you are in testosterone, then Opt Health is for you.That being said, the cause and effect relationship between reports of testicular tumors and the administration of clomiphene is not known.In the study, mean LH before treatment was 4.7 IU/L in the responder group and 13.7 IU/L in the non‐responder group.They will assess your symptoms and may adjust your dosage or recommend an alternative treatment approach to ensure your safety and well-being.For men contending with subfertility, reproductive urologists depend upon lifestyle counseling, empiric medical therapy, and targeted surgical management to improve fertility outcomes. Learn more about what to do if low testosterone levels are affecting how you manage your mental health. Balanced testosterone levels are a key factor in men’s health, and fortunately, Rex MD has got what you need to help boost your testosterone. These improvements in men’s health can lead to improved fertility, enhanced sexual health, increased muscle mass and strength, elevated mood and energy levels, and reduced risk of osteoporosis in men. These hormones stimulate the testicles to produce more testosterone and improve sperm production. Once his Hone doctor added clomiphene citrate to his protocol, his levels stabilized between 400 and 600 ng/dL, and his symptoms completely resolved. As a result, men who take Clomid with testosterone may be less likely to develop symptoms linked to high estrogen. When Clomid is added to testosterone therapy, it can help protect fertility. Testosterone replacement can lower sperm production, and in some men, it can even cause the testicles to shrink. One major concern with testosterone therapy is its effect on fertility. Keeping testosterone levels steady and balanced with Clomid may help avoid these problems. These drugs are negatively affecting the hypothalamus which, in turn, affects testosterone production.These treatments aim to relieve fatigue, improve muscle strength, libido and erectile function, as well as relieve anxiety, depression and irritability.As a result of the increased levels of FSH and LH, the testes produce higher amounts of testosterone.A lot of testosterone boosters on the market share common ingredients, but the quantities and combinations of the ingredients vary from product to product.A doctor will tailor the dosage based on hormone levels and fertility goals.The active form of B6 (called pyridoxal 5′-phosphate or P-5-P) is known to decrease prolactin levels. Taking Clomid is a fantastic step towards addressing low testosterone, but it’s not a journey you have to take with medication alone. These regular assessments help keep your treatment effective and safe. Regular check-ins and monitoring are a really important part of the Clomid treatment process. Should these tests confirm low T, your doctor will discuss various treatment avenues. Furthermore, exploring the world of herbal supplements like ashwagandha, tribulus terrestris, and fenugreek may offer additional support in naturally boosting testosterone levels.We will explore how Clomid works, the role of testosterone in the body, the potential benefits and risks of using Clomid as a testosterone booster, and alternative options available.Testosterone levels, which are measured in nanograms per deciliter of blood, naturally wane as we age.Cryptozoospermia refers to an extremely low concentration of sperm (less than 100,000 sperm per mL of semen).FSH is involved in the process of spermatogenesis, or sperm production, and its increased secretion can contribute to optimized testosterone production and improved fertility.This means they prescribe it because they’ve seen it work effectively to increase testosterone levels and improve sperm count.TRT typically involves administering synthetic testosterone through injections, directly supplementing the body’s deficient testosterone. Usually, you’ll want to start a higher dose to kick things off when your natural testosterone is at its lowest point, then decrease the dose for the second half of PCT. However, if you’re using a testosterone ester with a shorter half-life (Propionate, for example), then Clomid can be started as soon as 5 days after the end of your cycle. Starting Clomid in post-cycle therapy two weeks after your steroid cycle ends is most recommended. Low T can affect quality of life in men because it may lead to fatigue, sexual dysfunction, and other bothersome symptoms.“Taking care of your health is crucial for boosting fertility,” says Dr. Shusterman.The combination treatment is not very common, but it is becoming more discussed among doctors and patients.The most obvious approach, if you're looking for a pharmaceutical substitute and taking clomiphene for libido concerns, is to be tested for low testosterone and, if you qualify, obtain replacement medication.Clomiphene (brand name Clomid) is a selective estrogen receptor modulator (SERM).Most testosterone boosters should be completely safe for the majority of users. Together, we’ll find the right solution to help you feel energized, confident, and in control of your health again. We take a tailored approach, ensuring you get the proper treatment for your unique needs. They might not yield instant results, but they can significantly improve your health over time. Remember, lifestyle changes are an investment in your long-term health. It’s also important to note that fertility issues are often multifactorial—meaning there may be more than one cause at play. In other cases, medications like antibiotics may help treat infections that impair fertility. For example, some men might need surgery to correct a physical cause of infertility (such as a varicocele, or an enlargement of the veins within the scrotum). Before starting this drug, I tell my patients that they should anticipate transitioning to TRT after they are done having kids,” adds Calvert. “This can be a shocking change for some guys to go back to the symptoms that they used to have. By addressing hormonal imbalances at the source and stimulating the body’s natural testosterone production, clomiphene citrate offers a targeted approach to treating hypogonadism. This mechanism of action makes clomiphene citrate an effective therapeutic option for men with hypogonadism, a condition characterized by low testosterone levels. Most men see an improvement in testosterone levels within a few weeks, but noticeable changes in sperm function and fertility may take 3-6 months due to the sperm production cycle. Overall, Clomid is considered a safe option for men experiencing low testosterone, with the majority of patients tolerating it well and experiencing positive outcomes. It is important to note that individual responses to medications may vary, and it is recommended to consult with a healthcare professional before starting any treatment. However, studies indicate that most men tolerate Clomid very well and see improvements in symptoms within three months of starting treatment. Data on patient characteristics, comorbidities and dosage at start of treatment, are provided in Table 1. With the clinical knowledge in 2012 based on expert opinion at that time, men received CC, with a starting dosage of 25 mg every other day, or 25 mg a day in case of bodyweight above 100 kg. Hypogonadal symptoms were scored by the experienced treating physicians, no validated questionnaires were used. For males, the United States Food and Drug Administration (FDA) did not approve the medicine with reason of unclear clinical effect because of the lack of well‐controlled and well‐powered controlled trials.14, 15, 16, 17 However, CC is described over more than 30 years off‐label to hypogonadal men, especially those with an active or future child wish, or hypogonadal males who do not want to use TTh.18 Compared to TTh, CC is easy in usage and comes with little costs. Since the 1960s, CC has been often used for ovulation induction in females. Enclomiphene is certainly a better alternative to clomid for sure, however it’s not effective for long term treatment for testosterone replacement as a stand-alone. The fact is, they are tricking the body into producing higher levels of LH and FSH for those who aren’t secreting enough from the pituitary and keep some natural testicular production that may be lost when patients ARE taking testosterone. It contains ingredients common in multivitamins, as well as ashwagandha, a plant that has been shown, in some studies, to modestly increase your body’s natural testosterone levels. For patients looking to maintain testicular function and optimize their testosterone levels, clomid may be a great option. However, because some ingredients can affect blood flow and influence the activity of the testes and other parts of the endocrine system, we highly recommend speaking to your doctor before starting any new regimen to increase testosterone. Ingredients like zinc and boron have been shown to increase free testosterone.8 9 Your body can’t use the testosterone in that second camp to help improve exercise performance or burn fat. Here’s the good news—most side effects are temporary and go away once the medication is adjusted or stopped. In rare cases, men may experience gynecomastia (breast tissue enlargement), though this typically happens if the medication causes a significant spike in estrogen. Some men describe increased irritability or feeling more emotionally sensitive than usual. It’s no surprise since Clomid interacts with hormones that can influence how you feel. If you’re genetically predisposed to male pattern baldness (check out your father or grandfathers), your chances of suffering this side effect are high. While it poses zero harm to your physical health, thinning or hair loss on your head can zap your self-esteem when you’re a young guy. NSAA’s do not reduce your overall levels of DHT as 5-alpha-reductase inhibitors do. According to a clinical study published in Fertility and Sterility, Clomid significantly increased total testosterone levels in hypogonadal men without negatively impacting sperm counts. If needed to further boost testosterone levels, the daily dosage can be increased to 50mg based on lab results and patient symptoms. Based on clinical studies, Clomid has been shown to effectively increase testosterone levels for many men with hypogonadism (low testosterone). Ultimately, using Clomid is like telling your body to make more testosterone, versus administering it through gels, pellets, or injections. Results can usually be seen within 4 to 8 weeks of Enclomiphene treatment. It comes with mild side effects that usually subside after a few weeks of regular and proper use, making enclomiphene a safe medication for men. These side effects are usually temporary and subside as the treatment progresses. This increase is not as high as that of pellets or injections (testosterone shots), but it can make a big difference depending on how low it is. They initially developed Clomid to promote female fertility by increasing ovulation. Clomid blocks the interaction of estrogen with the pituitary gland and causes an increase in FSH and LH secretion. But when he quit steroids cold turkey seven years ago, he learned his years of steroid use had wrecked his body’s testosterone production. Back then, Carr didn’t worry about the increased risk of cardiovascular disease, hormone imbalances, and mental health disorders that came with the injections. CC is a good alternative for the treatment of symptomatic hypogonadal patients and has as advantages the absence of hypothalamus-pituitary-testicular axis block, the fact that it does not suppress spermatogenesis and does not cause polycythemia and its low cost (18, 31, 32). Taylor and Levine found elevation of TT levels in 104 patients treated with testosterone gel or CC. They noticed that testosterone levels rose in both groups, more significantly in the youth group. How long does it take to get testosterone levels back up? Unlike traditional testosterone therapy (TRT), Clomid doesn’t adversely affect sperm production, which makes it a preferred option for men desiring maximum fertility. Clomid (clomiphene citrate) is a medication typically known for its use in female fertility, but it’s also prescribed off-label for men with low testosterone. In addition to Clomid, other medications, such as testosterone replacement therapy (TRT), may be prescribed to individuals with clinically low testosterone levels. This dual benefit of increasing testosterone levels and improving sperm quality makes Clomid a versatile option for men struggling with fertility issues. As mentioned previously, Clomid works by blocking estrogen receptors in the brain, leading to increased production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). But with Clomid, these concerns are not an issue because it supports your body’s natural production of testosterone while also protecting fertility. If you were to stop taking TRT, your hormone levels could drop and there would need to be other ways to increase testosterone implemented. Clomid has a similar effect in males but we see an increase in testosterone and a reduction in estrogen. The one we've identified as having the best prices and the widest array of treatments is Hone Health. In men with low T, hCG performs like LH, providing additional signals to the testes that it's time to make more testosterone.28 Anastrozole acts as an aromatase inhibitor, preventing the enzyme from converting the extra testosterone.27 Residue from these products can affect puberty in children and have negative impacts on a woman’s health, especially if she’s pregnant, planning to become pregnant, or breastfeeding.55 You typically apply transdermal testosterone as a cream, gel, or patch (like a nicotine patch).54 It doesn’t have as intense a side effect profile as injections do, and it also eliminates the potential discomfort of injecting yourself. At some point in life, every male will start to notice the signs and symptoms of low testosterone. However, it is crucial to consult with a healthcare professional experienced in hormone therapy to ensure the best possible outcome for your specific circumstances. Scheduling routine check-ins with your healthcare provider enables them to assess the treatment’s effectiveness, make any necessary adjustments, and address any emerging concerns or side effects promptly. Regular monitoring of hormone levels via blood tests is essential to track progress accurately and fine-tune the treatment plan for optimal outcomes. One of Clomid’s most underappreciated advantages in men is its dual role in boosting testosterone while preserving — and often improving — fertility. Clomid stimulates the body to produce its own testosterone, while TRT provides synthetic testosterone to supplement or replace what the body no longer makes. For men who want to address symptoms like low energy, decreased libido, or poor concentration without compromising long-term reproductive health, Clomid represents a rarely discussed but clinically effective option. What many overlook is that Clomid doesn’t just raise testosterone; it supports the body’s entire hormonal feedback loop. Causes of primary hypogonadism include testicular infection, infarction, testicular cancer, gonadotoxic medications including chemotherapy, orchiectomy, trauma, and Klinefelter’s syndrome. Primary hypogonadism is classically defined by low testosterone and elevated gonadotropins. It is important to understand how the axis operates as our treatment options target various parts of the hormone axis. The diagnosis of adult onset hypogonadism consists of clinical and biochemical deficiencies of testosterone. These medications are used for a variety of reasons in medicine and since there is no specific FDA approval for use in hypogonadism, they are considered “off label” when prescribed for men with low testosterone. Over time, this can cause testicular shrinkage and lead to fertility issues. It works fast and can bring low levels back to normal or even high-normal ranges. It was originally developed to help women with fertility issues, but it’s also effective in men. Clomid is a type of medication called a selective estrogen receptor modulator (SERM). Second, because this was not a placebo controlled trial, it is difficult to conclude if clinical improvement is the result of CC therapy. Side effects were reported in 10% of our population and included agitation, hot flushes, nipple tenderness, mood changes, weight gain, visual changes, headache and dizziness. This potential predictor was also seen in the study of Mazzola et al. (2014).29 Without any confirmed mechanism, it is hypothesized that low normal range LH levels demonstrate a better potential for stimulating Leydig cells by CC. Furthermore, it could be considered that an elevated haematocrit before treatment or thromboembolic events in the past are contraindications. Although, it could be recommended then to do an early testosterone measurement, to evaluate the biochemical response and for early detection of a potential reversed effect. We measure LH levels in all men with low T at baseline prior to initiation of T therapy. CC was developed by Frank P. Palopoli, MS, in 1956 and commercialized by William S. Merrell Pharmaceutical Company, and the US Food and Drug Administration approved its use in the treatment of ovulatory dysfunction and infertility in women in 1967. CC is a mixture of enclomiphene (62%), which is a trans isomer with pure antiestrogen effect, and zuclomiphene (38%), which is a cis isomer that has a mixed action with a predominant estrogen receptor agonistic property. However, it may take up to 3 months for testosterone levels to reach their peak and for the full benefits of the medication to be realized. One of the primary factors to consider is the underlying cause of your low testosterone levels. During your initial consultation, your provider will assess your medical history, current symptoms, and overall health status to determine if you are a suitable candidate for this treatment. Before starting treatment with clomiphene citrate, it is essential to undergo a thorough medical evaluation to assess your eligibility for the medication. What should I know about potential side effects before talking to my doctor about Clomid? This is a really important consideration, and yes, Clomid can be a very helpful option if preserving or improving fertility is a priority for you. If I’m hoping to start a family, is Clomid a good option for low testosterone?