Furthermore, adverse effects are limited and it is considered a safe natural ingredient for ED. Though our review focuses on the top ten ingredients identified in a prior study, the current literature on several other common ingredients is presented here. Taken together, these data underscore the need for further studies to assess both the safety and efficacy of fenugreek therapy. Ouzir et al. more specifically reported significant spermatotoxic effects and decreased testicular weight in rat, mouse, and rabbit models. Saba et al showed that lymphocyte levels significantly increased after the oral administration of KRG extract to mice with reduced immunity compared to the control group, even when their neutrophil levels did not change . Although KRG may not significantly change cytokine levels in a healthy body, it may play a role in maintaining homeostasis in the body by regulating cytokine secretion in various disease conditions. Saba et al confirmed that the number of T cells and B cells in the spleen and thymus significantly increased when KRG extract was orally administered to mice with reduced immunity. Liquorice root (Radix glycyrrhizae, Gan Cao 甘草) However, further research is necessary to understand how these components contribute to ginseng's pharmacological properties. Many components of ginseng, such as ginsenosides, polysaccharides, peptides, polyacetylenic alcohols, and fatty acids, have been isolated and characterized , . Ginseng has been demonstrated to have an extensive range of pharmacological effects on the reproductive, cardiovascular, endocrine, and immune systems. It is a popular herb in the world, and is used in more than 35 countries as a food, health supplement, and natural remedy . Improvements in fatigue, vigor, and sexual and psychologicalwell-being were reported over time, with no statistically significantbetween-group differences. These herbs offer a diverse range of options for those looking to enhance testosterone naturally. Or, if you want an even easier option, simply check the labels of supplements to start making a difference. Try buying the above herbs in your local health food store and adding them to meals and smoothies. Native Americans use it for its relaxing effects to fight off exhaustion. The scientific name for the type of ginseng is Panax quinquefolius. According to facts, the property can vary depending on the type of ginseng you use. This includes improved immunity, mood, and cognition. On the other hand, scientific evidence points to its different effects. That said, there does appear to be at least some evidence for the use of Longjack root to elevate circulating testosterone. In addition to these findings, a study by Brown et al. utilized men of ages 19 to 29 years over an 8-week period . Many of these studies, however, had relatively low sample sizes, utilized women only , and enrolled subjects who were relatively young-between the ages of 19 and 29 24,126. Studies involving TT supplementation in humans have failed to yield positive outcomes with regard to elevating testosterone 23,24,126,127. One of the key ways ginseng may impact testosterone is through its role in protecting and supporting androgen receptors. Its benefits are particularly pronounced in maintaining androgen receptor robustness, making it a valuable supplement for those seeking balanced testosterone effects. Research, including studies on Korean Red Ginseng, indicates that it helps maintain healthy androgen receptors. This points to the idea that its effects may vary depending on individual circumstances and the baseline level of testosterone. However, conflicting research indicates that ginseng might reduce testosterone following intense physical activity, such as resistance training. It's vital to know about any possible side effects and interactions, even with healthy, reliable herbs such as Korean red ginseng. It appears that intake of ginseng significantly increases salivary levels of testosterone in younger women, while only slightly increasing them in older women. In addition, ginseng has been found to improve sperm count and quality in healthy individuals as well as patients with treatment-related fertility issues. Korean red ginseng is used in nootropics, which are supplements designed to boost mental performance and improve cognitive abilities. Panax Ginseng Meyer stands out among various types of ginseng as an adaptogen; that means it is believed to normalize body functions while strengthening systems that may have been compromised due to stress. Here we review the literature on the use of these ingredients and their efficacy and safety as treatments for ED. Studies characterizing the ingredient profiles of popular online ED supplements have revealed that most of these products are composed of varying quantities and proportions of these common ingredients7–9. Hundreds of ED supplements are available to consumers online and the sale of these products is likely to expand given that consumers increasingly prefer shopping online10,11. Furthermore, significant advancements in ED treatment have resulted from the development of sildenafil citrate and other phosphodiesterase type 5 (PDE5) inhibitors. Informed consent was obtained from each subject, and the study was approved by the Institutional Review Board of Kyung Hee University, East-West Neo Medical Center.Several scientific studies have revealed that ginseng can promote erectile function.This is likely tied to its ability to reduce oxidative stress in the testes and improve circulation to the reproductive organs.This systematic review includes randomized controlled trials examining the effects of herbs, spices, plants, and their extracts on testosterone concentrations in men.The university’s research also indicates that ginseng affects the central nervous system and significantly alters the activity in the brain that facilitates hormonal behavior and secretion.This plant grows in the United States and Canada, and it has been widely studied for its health benefits.Consequently, pharmacological ingredients that are related to the effect of ginseng on ED should be identified to elucidate the underlying mechanism of action (Ernst 2010). The polysaccharides in ginseng accelerate AR mRNA expressions to release adequate testosterone. Ginseng might have brought testosterone quantities to optimal levels by stimulating the androgen receptors to signal a reduction in testosterone synthesis. Another outlier research deduced that athletic bodybuilders subjected to intense resistance training experienced a drop in testosterone quantities due to Ginseng ingestion. Their blood lipids and hormones, including testosterone, remained unaltered. The test subjects were given four capsules of Ginseng berry extract or a matching placebo daily for eight weeks. If you try ginseng for its sexual benefits and feel over-stimulated, reduce your dose.As surprising as it may be, women can also be bothered by symptoms of testosterone deficiency.As public awareness of sexual health conditions grows, the demand for dietary supplements to treat these issues is likely to increase.In a small number of studies, the effects of Carob on improving semen quality parameters have been investigated.“Limited studies suggest that ashwagandha may slightly improve testosterone levels in males,” says Li.While ginseng is beneficial for both men and women, it is particularly useful for men’s reproductive health.Always consult with a healthcare professional before making any changes to your treatment plan.Future studies should consider investigating alternatives to conventional drugs, such as medicinal plants.Studies using a xenograft model of MCF-7 human breast cancer cells injected into nude mice have shown that engagement of only the membrane receptor by an estrogenic compound failed to stimulate tumor proliferation . Additionally, studies exploring its gene-regulating properties suggest it may offer broader benefits for managing stress-related performance challenges . While each supplement shines in specific areas, ginseng's ability to target both stress and performance makes it a versatile choice. How does ginseng stack up against other natural supplements? To maintain both stress management and performance benefits, take ginseng in the morning (between 7-9 AM) to align with cortisol regulation . Before starting ginseng, it's important to understand potential side effects and interactions. The BPH-1 cells were treated with various concentrations of KGC11o for 24 h, after which cell viability was significantly reduced in a dose-dependent manner. BPH development is related to uncontrolled proliferation and decreased apoptosis of prostatic cells . Serum PSA levels is mainly used as an indicator of the status of prostate cancer and is correlated with prostate size . The reviewed articles that pay special attention to this aspect provide scientific support for the benefits of ingesting ginseng as a supplement that improves prevention and, consequently, physical exercise performance in those who consume it. Injuries cause inactivity in subjects who exercise regularly, so prevention is one of the factors to take into account for an improvement in both sports and recreational performance and, of course, health. These arguments have led some of the studies reviewed to investigate the use of ginseng and its relationship with performance/prevention after exercising. You learn it aids vascular dilation by raising nitric oxide, so vessels relax and blood flows better. It can boost nitric oxide for better blood flow and firmer erections. Studies show it may increase swimming time in animal models. It may boost endurance mechanisms and even aid mitochondrial biogenesis, so your cells make more energy. Although we found that there was a significant efficacy of ginseng supplements on fatigue reduction, no sufficient RCTs were published in order to confirm this finding. First, preclinical studies, including in vivo laboratory studies and animal studies might not represent the biological mechanism in the human body. There are some possible biological mechanisms for the efficacy of ginseng supplements on mental and physical fatigue reduction and physical performance enhancement. Thus, there was no sufficient clinical evidence to support the use of ginseng supplements on reducing fatigue and enhancing physical performance. In this meta-analysis of RCTs, we found that the use of ginseng supplements had the efficacy on fatigue reduction, but not physical performance enhancement. The preventive role of the red gingeng ginsenoside Rg3 in the treatment of lung tumorigenesis induced by benzo(a)pyrene The PubMed and Web of Science databases were searched for relevant studies (up to December 2022). In the present study, we systematically reviewed the existing relevant literature, analyzed the efficacy of RG in MRH through clinical evidence, and elaborated its related mechanisms along with basic research to provide a reference for the future application of RG in MRH. Moreover, to date, these studies have not been analyzed in detail from a holistic perspective. Red ginseng (RG) is a cooked product of ginseng that undergoes several processes, such as infiltration, cleaning, sorting, steaming, and drying, and it is widely used as an herbal medicine in some East Asian countries. Given the influence of traditional sexual concepts, many men are reluctant to admit that they have a reproductive disorder. Hence, it is advisable to obtain an opinion from the doctor before determining your dosage of supplements. However, if it is in impure or mixed form, it can cause certain side effects. Another important aspect is that ginseng needs to be consumed in its pure form. Immunotropic activity of panaxans--bioglycans isolated from ginseng. Wild Panax ginseng (Panax ginseng C.A. Meyer) protects against methotrexate-induced cell regression by enhancing the immune response in RAW 264.7 macrophages. Jie YH, Cammisuli S, Baggiolini M. Immunomodulatory effects of Panax Ginseng C.A. Meyer in the mouse. Studies have found that ginseng may help to support energy production and reduce tiredness. Those people who often find that they run out of energy in the middle of the day may find that the chemicals in ginseng help them get through the day more effectively. The cell cycle is the process by which cells normally grow and divide. The use of ginseng might also have a positive effect on the brain. The men then had levels of certain inflammatory markers tested after performing an exercise test. In one study conducted by Korean researchers, men with low sperm count were given either placebo or 1g of Panax ginseng daily for 12 weeks. Other studies have found benefits when taking panax ginseng for longer periods of time than just 8 weeks. More recently, it has been studied for its potential effects on testosterone production and its ability to increase muscle mass and strength. While discontinuation of minoxidil leads to recurrence of alopecia, prolonged use of finasteride causes male sexual dysfunction and appears as a major cause of infertility and teratogenicity in females 6,7. In this sense, TT could be used as a supplement to maintain optimal testosterone levels. Therefore, inadequate total testosterone levels may serve as markers of poor prognosis in COVID-19 . Testosterone is the main male sex hormone, produced mainly in the testicles. Keep scrolling for the best foods to boost testosterone. This is why it's important to give your T-levels some attention every now and again. Your testosterone is the foundation of your existence. Subjects were responsible for daily ginseng consumption; consequently, the authors rely on the assumption that each subject complied. Furthermore, our results indicate that an ergogenic effect of ginseng intake on salivary DHEA occurred in women, and that it was greater in women aged 38–50 years than those aged 20–32 years. Comparison of macronutrient intake (energy, protein, carbohydrate, and fat) of groups A and B volunteers pre and post ginseng supplementation. There were no significant differences in group A’s macronutrient intake between pre and post ginseng supplementation (Table 2). The name refers to the velvety skin covering growing antlers of male elk, deer, and moose, which can be removed with no harm for the animal. Some Ginkgo extracts may contain 4′-O-methylpyridoxine, which is a neurotoxin also known as “ginkgotoxin.” Ginkgotoxin poisoning is characterised by epileptic convulsions, vomiting, unconsciousness, and irritability, which may be fatal if not promptly treated . It is generally accepted that Ginkgo extract is well absorbed in humans, rats, and rabbits after oral administration . A recent review on the pharmacokinetic properties of these substances concluded that the available pharmacokinetic data are rare and more studies need to be conducted . The most commonly used Ginkgo biloba extract is EGb761, which contains flavonoid glycosides, mainly composed of kaempferol, quercetin glucorhamnoside esters, and terpenes of ginkgolides and bilobalides. While they can be highly effective, especially if you have clinically diagnosed testosterone deficiency, their usage can lead to potential side effects. On the other hand, synthetic testosterone boosters are often available as prescription medications or over-the-counter testosterone supplements. These natural sources are believed to work by enhancing the body’s own testosterone production or by influencing sex hormones. Research on Malaysian Ginseng’s effects has provided evidence of its testosterone-boosting effects. Recent studies have started to show garlic’s role in testosterone production. We included nine studies that compared the effects of ginseng against a placebo (dummy drug). For specific concerns about testosterone levels, it is always recommended to consult with a healthcare professional. While Siberian ginseng is not a direct testosterone booster, its profound adaptogenic properties make it a valuable herb for supporting overall vitality, stress management, and energy levels. But no exercise is going to drive your T levels through the roof, and it won’t be a prolonged increase. “You should exercise to keep your endurance, lean muscle, and low body fat, which will, in turn, keep you healthy,” El-Zawahry says. Obesity is linked to low testosterone and other health problems. “If we are going to summarize the results of these studies in one easy statement, exercises do not significantly change testosterone level,” he says. Illustrated effects of ginseng, estradiol, and α-zearalenol on boar spermatozoa. A fourth study found no significant difference in the frequency of hot flashes between the ginseng and placebo group. In one 1997 study, rats were given ginseng injections, and after two weeks, the treated group showed a significantly improved bacterial clearance from the lungs. After day 12, the glucose tolerance in the mice increased, and overall blood glucose levels decreased by 53 percent. By day five, the mice taking the extract had significantly lower fasting blood glucose levels. Speak with your healthcare provider before beginning ginseng or any supplement if you want to use them for treating erectile dysfunction.It increases blood circulation which better prepares the male for the heart-racing excitement of sex.Shukla R, Kumar M. Role of Panax ginseng as an antioxidant after cadmium-induced hepatic injuries.Ginseng polysaccharides (GPs), as a representative active ingredient of ginseng, can modulate immunopotentiation function, improve intestinal metabolism, alleviate inflammation and oxidative stress, enhance anti-cancer activity, and especially regulate gut microbiota (6, 104).Another study reported that whole ginseng extract could effectively alleviate high-fat-diet-induced nonalcoholic fatty liver disease symptoms by regulating gut microbiota and enhancing the gut barrier function (35).To date, several randomized controlled trials (RCTs) have reported the efficacy of ginseng supplements on fatigue reduction (12,13,14,15) and physical performance enhancement (16,17,18,19,20,21,22,23).Theoretically some of the components of panax ginseng could potentially harm fetal development and the embryo.The second RCT reported positive effects of KRG on menopausal symptoms.The study also recorded a change in the WBC differential count after the intake of the test substance for 8 weeks (data not shown).This verification process builds trust and ensures you can confidently use products that meet quality standards and protect your health. After extensive washing in TBS buffer, the membranes were then incubated with secondary antibody in blocking buffer containing 5% nonfat milk for 1 h at room temperature. The blood was collected and centrifuged at 3000 ×g for 15 minutes to separate the serum. At the end of week 13, blood samples were withdrawn from the abdominal aorta under ether anesthesia. Study participants typically used ginger supplements, which improve testosterone levels by enhancing luteinizing hormone production, normalizing blood glucose and reducing oxidative stress. A review showed the beneficial effects of fenugreek supplementation on testosterone levels, as well as some evidence favoring Asian red ginseng and forskolin root extract. Numerous rodent studies exist demonstrating reduced anxiety and improved sexual performance following tongkat ali feeding 37-40, with such effects thought to be due to a restoration of normal testosterone levels. The authors concluded that the enhancement of sexual function exhibited a gradual improvement over a period of time, with a more pronounced effect seen in the group administered with ginseng.80 These studies imply that ginseng may help increase female arousal and sexual desire, yet, more research is required to substantiate these benefits. Moreover, 8 wk of supplementation with an ashwagandha root extract resulted in a significant increase in both muscle strength and testosterone concentrations (62).There is speculation that nettle leaf may help with male pattern baldness.Siberian ginseng, also known as eleuthero, is a type of ginseng that is native to Asia.Its adaptogenic properties make it a powerful supplement for anyone looking to support their body’s natural hormone balance.The testes are where most of the testosterone is produced, so less damage to the testes may support testosterone levels.Additionally, a topic cream with ginseng is also available.While participants were encouraged tomaintain regular lifestyle habits during the study, this was not adequatelymonitored. We will update the literature if it is more than six months from the publication date, and incorporate any new studies if identified. If the control groups are related to other types of herbal medicines and complementary therapies, we will exclude those studies. Trials in which ginseng forms part of a complex herbal medicine will be excluded. This review will update and critically appraise the current evidence regarding the use of ginseng to treat ED. Ginseng Increases Testosterone Levels Two review authors (Lee HW, Kim T‐H) will independently scan the abstract, title, or both, of remaining records retrieved, to determine which studies should be assessed further. We will also contact the main manufacturers of ginseng products to identify unpublished and relevant trials. We will contact the authors of the included studies and researchers in the field with regard to any potential ongoing and unpublished studies, if necessary. The bibliographic references of all included trials will be reviewed to identify other potentially relevant studies. We will search for ongoing studies by accessing the following databases. Medications changed by the liver (Cytochrome P450 2D6 (CYP2D substrates) interacts with Panax Ginseng It may be apparent that exposure to excessive psychological stress for extended duration of time will give negative impact on male reproductive system. Levels of serum testosterone, testis index and structure, senescence and apoptosis of sperm cells, and oxidation-related biomarkers and inflammatory cytokines were compared between single D-Gal-treated (positive control) and Rg1-administered (test) group. However, ginseng attenuated the increased expressions in all the three regions, exhibiting therapeutic benefits on the symptoms of BPH and helped in nerve growth factor activation. In an animal experiment BPH was induced by testosterone in rats (250 ± 10 g) and the animals were treated with ginseng (200 mg/kg, p.o.) for 4 weeks. The collected serum and prostate tissue were used to determine 5AR1 and 5AR2 levels using the SRD5A1 and SRD5A2 ELISA kit (Cusabio Biotech, Wuhan, China). Blood sera were separated by centrifuging the blood at 3000 g for 20 min at 4 °C for analysis. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) serum levels were measured using a GOT/GPT kit (Asan Pharmaceutical, Seoul, Korea). P. notoginseng was shown to inhibit phospholipase A2 activity , and perhaps P. ginseng has a similar activity, preventing the P4 activation of phospholipase and delaying AR . Although AR was not induced in ginseng-, E2-, or α-zearalenol-treated spermatozoa with the addition of P4 alone, rates of AR with P4 and ionophore were induced in the samples in a similar manner as with ionophore alone. Adding a calcium ionophore to samples enabled the spermatozoa to overcome the cellular changes induced by ginseng and α-zearalenol, which inhibited AR. AR is preceded by phospholipase activation , and ginseng has been shown to inhibit phospholipase activity , . We also did our best to select testosterone booster supplements that have been third-party tested. We work with a certified nutrition coach during testing to find the most effective and safely formulated testosterone boosting supplements. “Two of the ingredients in this formula, the ashwagandha and the tongkat ali (Eurycoma longifolia) have the strongest clinical data supporting small to moderate increases in testosterone,” Pete said. This could work well as a recovery supplement for athletes, since it can help reduce stress, improve sleep, and may provide some basic hormonal support.” 2. Sexual Function: FSFI Meanwhile, another team of researchers, in a more recent human study involving women of varying ages, also found that ginseng intake for seven days led to a prominent rise in salivary testosterone levels and DHEA. One of the early yet significant studies demonstrated that a higher dose of Panax ginseng (5%) supplementation in animal subjects for 60 days led to a significant rise in testosterone levels. Hence, if your testosterone levels are low, ginseng enables your body to secrete more, and vice-versa. Ginseng provides numerous benefits, such as decreasing inflammation and fatigue, enhancing erectile function, and boosting energy and testosterone levels. Other Noteworthy Benefits Of Ashwagandha! A study investigated the impact of Siberian Ginseng supplementation on cyclists. The type of ginseng is popular for supplementation. Here is the study that gives a clear indication. These contain these compounds in higher quantities than other types of ginseng. More basic research is needed to understand fully the mechanisms of action of red ginseng. Others have postulated that red ginseng might induce relaxation of the smooth muscles of the corpus carvernosum via the nitric oxide (NO) pathway 14, 18, 19. Four of trials employed 600 mg, three times daily as treatment, while two trials used 900 mg and one study 1000 mg. The single dose studies used quantities ranging from 1800 mg to 3000 mg of its extracts. Almost all medical products are derived from ginseng after 4 to 6 years of cultivation. The annual stalk growth from ginseng’s rhizome is an important identifier in distinguishing ginseng from other ginseng-related products 11, 12. A matured 6-year-old ginseng on average would have a total root length of about 34 cm, with the primary root being about 7-10 cm long and 3 cm wide, with several stout rootlets. Akoranga also suggest that it enhances sleep quality, reduces anxiety, and even supports male reproductive health by improving sperm quality.Studies suggest that Panax ginseng can stimulate testosterone production by increasing luteinizing hormone (LH) levels in the body.The oral administration of American Ginseng (10-100mg/kg) to rats for 28 days did not appear to affect testosterone or LH levels.Yes, Panax ginseng can work like Viagra to a certain extent by positively affecting erectile function by increasing blood flow.When cayenne is ingested, it acts to dilate blood vessels, allowing blood flow to increase to all areas of the body, especially major organs (5).It appears that the substances contained inside it may protect blood vessels & tissue in the penis from oxidative stress and assist in the restoration of normal function.The most impressive health benefits of ginseng include its ability to stimulate the mind, increase energy, soothe inflammation, reduce stress, and prevent aging.Ginseng continues to be used to improve sexual performance and is the most commonly used ingredient in men’s health supplements for ED. Various studies have also discussed its effects in terms of men’s health and fertility. Moreover, their sexual health has improved tremendously. It comprises Korean red ginseng to stimulate testosterone production. With more quality male hormones, your body processes improve. On top of that, it encompasses an extract of ginseng with remarkable t-boosting effects. Isolation of testes and blood serum for qRT-PCR, western blotting, and ELISA While testosterone levels play a major role in erection functioning in men, the possible reason could be that ginseng enhances the nitric oxide release in the blood, leading to better blood circulation and oxygen flow across the body. Beyond this, studies show great promise of Korean red ginseng extract increasing testosterone levels, follicle-stimulating hormone, and luteinizing hormone (LH) . In an acute study (2 h) conducted in 8 men with a mean age of 21.3 ± 0.7 y, supplementation of 20 g of Korean red ginseng root extract did not increase testosterone concentrations (65), while in 30 healthy, endurance-trained men, aged between 18 and 40 y, Panax ginseng (an ethanolic liquid extract equivalent to 2 g of dried root, daily) did not increase testosterone concentrations after 6 wk of supplementation (38). Rangahau shows that red ginseng can improve erectile function by boosting blood flow and nitric oxide production. A 2022 study suggests that ashwagandha may help increase testosterone levels, improve sperm quality, and enhance exercise performance. Most studies suggest that doses ranging from 200 mg to 1,000 mg of standardized ginseng extract per day may be beneficial. Second, ginseng has been shown to improve insulin sensitivity and support metabolic health. Whole ginseng root, ginseng extracts, and ginsenoside-enriched formulations may produce different effects due to variations in bioavailability and potency. Numerous studies have explored the relationship between ginseng and testosterone, with mixed results. Effect of compound K, a metabolite of ginseng saponin, combined with gamma-ray radiation in human lung cancer cells in vitro and in vivo. Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells. The effects of ginsenosides Rg3 on the expressions of VEGF and KDR in human lung squamous cancer cells. Red ginseng extract protects against aflatoxin B1 and fumonisins-induced hepatic pre-cancerous lesions in rats. Enhances Athletic Performance While participants were encouraged tonot engage in any dietary, exercise, or lifestyle changes during the study, it ispossible that these motivated individuals may have implemented changes that hadpositive effects on their energy, vigor, and general well-being (e.g., changes inwork, relationships, diet, and physical activity). Improvements in fatigue, vigor, and sexual andpsychological well-being were observed after both ashwagandha and placebosupplementation with no statistically significant group differences. To evaluate the efficacy of condition concealment over the study, participantswere asked at the completion of each phase of the study to predict conditionallocation (i.e., placebo, ashwagandha, or uncertain). Ashwagandha was welltolerated with no significant differences in reported adverse events betweenplacebo and active drug treatment groups. No participant withdrew from the study due toself-reported adverse effects from tablet intake. It should be part of a comprehensive approach to health that includes a balanced diet, regular exercise, and proper medical care. Additionally, the nutrients in suma root can support overall health, which is essential for hormone production. While more research is needed to fully understand its benefits, the existing studies are promising. When we’re stressed, our bodies produce cortisol, which is necessary for the ‘fight or flight’ response. Although treatment using herbal medicines, including Eurycoma longifolia, has been investigated, the benefits remain unclear.In Table 3, the body mass, fat mass, and free fat mass of the CG and IG at T1 and T2 are shown.However, Suh et al reported that cancer patients had no changes in lymphocyte and monocyte count after taking red ginseng .Join healthcare leaders for live online sessions and Q&A — delivering evidence-based strategies to guide patients toward lasting longevity.The name of this plant was derived from a Chinese word that translates to "person plant root," which refers to the forked shape of the ginseng's root that loosely resembles a pair of legs.Our team of expert testers has tried hundreds of the most popular supplements on the market today, using our comprehensive supplement testing methodology to find the best products for all folks.Ginseng is an incredibly common ingredient in energy supplements, and for good reason.Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells.Historically, the use of sexual tonics in various forms has been practiced to improve sexual functions. Unlike some herbs that primarily increase free testosterone by inhibiting SHBG (sex hormone-binding globulin), ginseng works by enhancing overall vitality, improving circulation, and supporting adrenal function. Ginseng is one of many natural herbs believed to influence testosterone levels, but its mechanism of action differs from other supplements like ashwagandha or fenugreek. For individuals considering ginseng as a natural approach to supporting testosterone levels, several factors should be taken into account. Studies have suggested that ginseng supplementation can enhance glucose metabolism and reduce inflammation, both of which may positively impact testosterone levels. Insulin resistance and metabolic syndrome are closely linked to lower testosterone levels, so improving metabolic function can indirectly support hormonal balance. Unfortunately, monitoring ofchanges in these areas over the study duration was not undertaken. Efficacy of groupconcealment was high as only 35% of participants correctly guessed treatmentallocation, 30% of participants were uncertain of treatment allocation, and theremaining 35% incorrectly guessed group allocation. Mean salivary hormone levels during each crossover period are detailed inTable 3 andFigure 3. Mean scores in the AMS total score, POMS Fatigue-Inertia subscale score, andPOMS Vigor-Activity subscale score during the crossover period for the twotreatment groups are detailed in Table 2 and Figure 2. Demographic characteristics are presented in Table 1 and indicate that the studypopulation was homogeneous, with no statistically significant differencesbetween the groups on baseline demographic characteristics. Conversely, in the Ginkgo + Ex group, both levels remained unchanged when compared with the normal and BPH control groups (Figure 3(a)). As contrast, exercise significantly reduced the total PSA levels in both the Ex and BPH + Ex groups. Ginkgo elevated the levels in both the Ginkgo and the BPH + Ginkgo groups significantly to 57 ± 6 pg/mL and 68 ± 9 pg/mL. These levels were significantly lower than in the placebo group, lasting for up to 72 hours after testing. In particular, if it would increase male sex drive. The focus of the research was also to gain more details on how the use of ginseng would affect a male patient’s mind. These patients complained about poor erectile function. Their study has also shown that Rg1 increases the number of T-helper cells in relation to the total number of T-cells and natural killer activation of splenocyte . This immunoactivity of red ginseng has been demonstrated in many in vitro and in vivo clinical studies . For vital signs (systolic and diastolic blood pressure, pulse, and body temperature) measured during each visit, there was no statistically significant change between the screening and the end of the study (Table 5). In this light, the present study sought to examine the changes in the immune cells of healthy subjects after ingesting KRG. The herb has been shown to be effective in improving cognitive function, reducing stress, boosting energy levels, and improving sexual health. Some studies have suggested that ginkgo may also be beneficial for men’s sexual health, as it may help improve blood flow to the genitals. A study published in the Journal of Ethnopharmacology found that ginseng can improve insulin sensitivity and reduce blood sugar levels. A study published in the Journal of Ginseng Research found that ginseng supplementation can reduce stress and improve cognitive function in middle-aged adults. Chemical profiling studies on different deer antler samples have found that it contains naturally occurring steroids such as testosterone, androsterone, oestradiol and progesterone.(25,26) While there are no published clinical reports on virilisation due to deer musk or deer antler consumption, the inherent presence of androgenic compounds in these two deer products is proven and may be clinically relevant with prolonged use. A few cases of pseudoaldosteronism caused by consumption of liquorice at high doses have been reported in the literature, demonstrating the clinical significance of the mineralocorticoid activity of the herb when consumed in large quantities.(11) Healthy volunteer studies that investigated the safe dose of liquorice reported that a daily dose of 2 mg/kg of glycyrrhizic acid did not have any effect on aldosterone level, blood pressure, potassium and fluid retention.(12) Translating this to a person who weighs 50 kg, the safe dose of glycyrrhizic acid would be 100 mg. No drugs used thus far for treatment of ED have shown simultaneous effects on the peripheral and central nervous systems. If we had performed nocturnal tumescence or ultrasound studies, we could have evaluated the mechanism of the observed effects of TMGE. Whether you’re aiming to improve your workouts, manage fatigue, or support overall wellness, ginseng may offer noticeable benefits. American ginseng is milder and better for stress and immune support. This helps avoid potential side effects like insomnia or jitteriness and allows your body to reset its response. Studies suggest that Panax ginseng may improve physical endurance and stamina by reducing exercise-induced fatigue. Look for high-quality supplements labeled as Panax ginseng (Korean or Asian) or American ginseng, depending on your goals. The authors evaluated agents which increase the quantity of semen or stimulate the production of semen; substances which purify and improve the quality of semen; agents which improve ejaculatory functions and delay the time of ejaculation; agents which improve ejaculatory performance and arousing sexual desire.In other reports showing BPH improvement using P. ginseng, the prostate weight, DHT levels, and epithelial layer thickness were similarly reduced as in this study 34,35.There are various types of ginseng, including Korean red ginseng, American ginseng, and Siberian ginseng.Likewise, topical administration of ginsenoside Re on to the back skin of nude mice for up to 45 days significantly increased hair-shaft length and hair existent time, and stimulated hair-shaft elongation in the ex vivo cultures of hair follicles isolated from C57BL/6 mouse.In the present study, the mixture of P. ginseng and bee pollen is designed as formula KH053.The more current scientific term is “adaptogen,” a plant that helps the body cope with a wide range of challenges. Consequently, peer‑reviewed clinical data are limited, and most evidence comes from small, often open‑label studies or independent laboratory analyses of individual ingredients. He attributes it to long work hours, erratic sleep, and mildly elevated blood pressure. You should always consult with a qualified health care professional before starting any exercise, diet or supplement regimen. The information presented on this site is for educational purposes only and is not intended to replace advice from your physician or other health care professional or any information found on any product label or packaging. Check with your doctor before using this product if you are using medication, including anti-coagulants (blood thinners) or have any medical conditions. In particular, women were more vulnerable to COVID-related distress which in turn could aggravate menopause-related disturbances. During this steaming process, the components of ginseng undergo physio-chemical changes forming a variety of potential active constituents including ginsenoside-Rg3, a unique compound in KRG. KRG is produced by repetitions of steaming and drying of ginseng to extend preservation. Ginseng originated in South Korea, which later spread to China and Japan, has a wide range of pharmacological activities including immune, endocrine, cardiovascular, and central nervous system effects. It is believed that ginseng can help regulate the production of hormones like testosterone, cortisol, and adrenaline. It is important to note that while ginseng may have potential benefits for exercise, more research is needed to fully understand its effects. Additionally, ginseng may help improve recovery time after exercise, allowing individuals to train more frequently and effectively. Research has shown that ginseng may have potential benefits for heart health. Ashwagandha is an adaptogenic herb that helps enhance the body’s ability to deal with stress and reduce cortisol levels. If you have vitamin D deficiency symptoms, it will decrease your testosterone levels. One of the most important nutrients that can help boost testosterone levels is vitamin D3. Two RCTs investigated the efficacy of ginseng for sexual function in pre- and postmenopausal women.10,11 One RCT failed to show effects of ginseng on sexual function. The extracted data included the authors, year of publication, country, sample size, age of the participants, types of ginseng, dose, treatment duration, main outcomes, and adverse effects. All prospective randomized clinical studies that compared the effects of any type of ginseng on menopause symptoms with those of a placebo were included. Unblinding is, therefore, a further possibility for potential overestimation of the treatment effects which is known as performance bias . Three RCTs 7, 12, 14 used starch with ginseng flavour for placebo but others 6, 10, 11, 13 did not report details about the placebo. Trials with inadequate blinding and inadequate allocation concealment may lead to selection bias and are likely to show exaggerated treatment effects. To the best of our knowledge this is the first systematic review and meta-analysis of RCTs on the effectiveness of red ginseng for ED. Three trials used the International Index of Erectile Function (IIEF) 7, 10, 14, while one RCT employed Watts sexual function questionnaire . This content does not imply any medical claims and is not intended for self-diagnosis or self-treatment of any condition. Dr. Meghan Scott is a certified nutritionist and health coach with a passion for helping people achieve their wellness goals. Having over 20+ years of experience in bodybuilding, helped many individuals to get jacked by different steroid cycle. Apart from his bodybuilding obsession he loves to write & share his personal experience about his weight loss & Fitness journey. With so many male enhancement products available today, choosing the right one can be confusing. At the fifth day, they performed 4 sets until concentric failure of a half-squat exercise, with eccentric action increased by using an eccentric-inductor device attached to their knees. It awaits a large scale randomized clinical trials to prove that KRG plays beneficial role in climacteric disturbance for both male and female. Among the 16 studies, 11,169 breast cancer cases and 648,913 participants were identified and included in the data analysis. TT supplementation did not impact enhance performance or body composition in CrossFit® male athletes. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. We are the ultimate online shopping experience for nutritional supplements, fitness supplements, natural beauty products, and gifts such as American ginseng. Historically, the use of sexual tonics in various forms has been practiced to improve sexual functions. In conclusion, it is highly likely that P. ginseng is the botanical with the potential to enhance male sexual capacity. In this review we attempted to evaluate the usefulness of P. ginseng as a medicinal herb for male sexuality revitalizer. Meyer (P. ginseng), has long been recognized for its potential to enhance the sexual well-being of individuals, particularly on males. Of all the potential therapeutic effects of ashwagandha, stress reduction — and specifically the levels of the stress hormone cortisol — is the one with the highest level of clinical evidence behind it. While the studies so far have been small, there are some positive early indications that it’s a good ingredient for testosterone supplements. The final one of the herbs we have here is an African plant that has been used for generations to improve sexual development and counteract low testosterone. The only thing missing in studies is to verify whether it may also improve sexual performance, which would give it a triple benefit. One study found a direct link to it improving erectile dysfunction . KRG is known to regulate the body's immune response by regulating the secretion of cytokines, which mediate the immune response . Also, KRG was reportedly effective in enhancing immunity by significantly increasing the number of WBCs in blood . The oral administration of RGAP (a well-known immunoactivity ingredient in KRG) in mice led to a significant increase in LPS-stimulated B cell proliferation and concanavalin A-induced splenic T cell proliferation compared to the control group .