The root is believed to provide a range of health benefits, attracting attention for its role in improving sexual function, particularly in men dealing with issues like erectile dysfunction. Note that some types of maca root powder extract come in gelatin form but this doesn’t mean it contains any added gelatin. According to a 2017 study, maca can help alleviate menopausal symptoms, including hot flashes, night sweats and interrupted sleep. Chinese postmenopausal women showed a significant decrease in depression after maca treatment. The maca root, known as the hypocotyl, looks like a turnip and is the part that brings numerous amazing benefits. Maca root comes in a variety of colors and we’ve found that black maca is typically the best overall maca for men. Free testosterone is unbound to other proteins and can connect with any cell in the body. However, the energizing effects noted by males taking maca suggest that it is otherwise having a positive effect on the endocrine system. Before the injection of CYP, the bodyweight of ginseng group, AEM-L group and AEM-H group did not significantly change, compared with the normal group (Fig. 1c). The total protein in each spleen was extracted with lysis buffer, and 50 mg protein was resolved on a 10% sodium dodecyl sulfate polyacrylamide gel. Blood was collected in clean test tubes with or without ethylenediaminetetraacetic acid (EDTA) following eyeball extraction. Clinical studies, primarily focused on sexual health, indicate improved sexual desire, erectile function, and subjective wellbeing in men. How long it takes maca to balance your hormones depends on the underlying causes of hormonal imbalances. How long maca takes to work for you depends on your symptoms and any existing health conditions. For many people, the best time to take maca root is in the morning. Some maca root powders come in combinations of different forms. Currently, one study suggests that Maca may possess blood pressure reducing properties via ACE inhibitory activities in a dose-dependent manner, with the heat-treated extract outperforming the raw extract. A study conducted with varying doses (0.125, 0.25, 0.5, and 1g/kg) Black Maca in a model of alcohol-induced memory impairment when both were administrated orally for 28 days noted that all doses of Black Maca were able to abolish the increase in escape latency (time required for the mice to remove itself from the maze) seen with alcohol, and trended to improve time relative to control. One in vitro test with neurons isolated from Crayfish noted dose-dependent protection against hydrogen peroxide when neurons were pretreated 3 hours before H2O2 treatment, this pentane extract of Maca possessed an EC50 of approximately 2.8μg/mL and exerted 88% protection when 30μg/mL was used. A comparative study in ovariectomized female rats using 1g/kg Maca (Red, Yellow, and Black) all three forms appeared to improve cognition as assessed by a water finding task with Black outperforming the other variants. Prior to the clinical study on perimenopausal women, toxicity of the batch of Maca-GO received for use in the study was determined on male and female rats according to Litchfield-Walloon’s method modified according to the harmonized OECD procedure (20). The aim of this double blind, crossover, and randomized pilot clinical study was to determine the effect of the oral administration of capsules containing pre-gelatinized dried and pulverized hypocotyls of Maca (Lepidium peruvianum Chacon) on quantitative physiological responses and alleviation of symptoms contributing to menopausal discomfort in perimenopausal women. Multi-functional effect of Maca on endocrine relationships may also explain reported in the literature, its positive influence on stimulation of endocrine glands in regulation of hormonal balances in the body (4, 10) and particularly in women entering a perimenopausal state of life. Since the first report of Chacon on medicinal properties of Maca root (3), it has been generally accepted and confirmed in number of studies, that this plant doesn’t contain plant estrogens or any other phytohormones (13-17), but through plant sterols, stimulate endocrine system helping to maintain hormonal balance (1) in a way that is not yet well understood (2, 18). Laboratory assays on male and female rats demonstrated also that Maca-GO may also be considered as a non-hormonal energizing supplement, assisting not only physically-active people and sportsmen, but in those women complaining on lack of energy and stamina, often experienced by women entering menopausal stage of life. For men prostate function is essential for producing semen, hormone production, erectile function, urine flow and sexual pleasure. Red Maca root gave the best results and benefits, so keep your bones strong by adding some to your morning tea or breakfast every day. For males clinical studies have shown that Maca can improve sexual parameters relating to copulation (sexual function and performance). Testosterone is a hormone that plays a crucial role in men's overall health, including everything from maintaining bone and muscle mass to regulating sex drive and mood. While yellow maca is great for energy, red maca might lean more towards improving mood and balancing hormones. Traditionally, maca is consumed as a root vegetable, much like a potato. If you’ve ever been to a health store, you’ve likely seen maca marketed as a supplement to boost energy and libido. With its rich nutritional profile, it’s no wonder indigenous people swear by its health benefits. Not any statistically significant differences between semen parameters in different collection dates as well as maca versus placebo groups were found. Out of 18 remaining volunteers, 7 consumed placebo and 11 maca. All the participants signed agreements to be involved in the study after being informed of its purpose, possible benefits, and risks and approval from an independent Ethics Committee was obtained. Some studies suggest that it may have a positive impact on testosterone levels. In order to get the best outcomes of maca root we suggest you not overdose on the supplement. Potentially, it’s a great approach for people with low levels of testosterone or who have the symptoms of menopause. The potent herb is known to be an effective way to balance both testosterone and estrogen levels in both men and women. Toxicity of Maca-GO used in the study was determined in bioassay on mice and rats. Some studies have also suggested that Maca may have antioxidant properties, which can help protect the body's cells from damage caused by stress - related oxidative stress. Instead, it may offer a natural way to support the body's own hormonal regulation mechanisms. Although the exact mechanism is not fully understood, some studies indicate that Maca may play a role in regulating testosterone within a normal range. Men often turn to it for its libido-boosting effects and testosterone support properties - claims which it can almost stand by. In addition, the studies used different dosages and forms of maca, making it difficult to draw definitive conclusions. More research is needed to determine whether maca has similar effects in humans. Does maca root increase libido? When combined with a boost in libido, maca has been seen to help men overcome mild erectile dysfunction. First, its high-nutrient content and several vitamins including iron, potassium and manganese revitalizes the entire body. Among the top reasons men choose to take maca is to restore their libido. Starting with a small dose and gradually increasing can help minimize these effects. Maca is typically well-tolerated, but some users report mild side effects. This allows your body to adjust and helps identify the optimal amount for your needs. The root is additionally a good source of vitamin C, which supports immune function, and various B vitamins including B1, B2, B12, and choline. Both traditional and modern supplementation methods offer practical ways to incorporate this Andean superfood into daily routines. Over the past couple of decades, the demand for maca has skyrocketed as more people become interested in natural remedies for low libido and fertility challenges. Though maca has been a staple food and medicine in Peru for thousands of years, it's only recently become popular in the U.S. In Peru, maca has been used as a food and natural medicine for at least 3,000 years. Maca1 is derived from the root of Lepidium meyenii, which is a perennial plant that grows at high altitudes in the Peruvian Andes. May ease menopause symptoms After taking maca, many individuals report feeling energized, with enhanced mood and increased vitality. Responses may vary depending on dosage, body chemistry, and specific hormonal challenges. Maca can improve hormonal balance within a few weeks to a couple of months of consistent use. This effect of Maca-Go on rats with active ovaries may be extremely valuable when extrapolating results from the laboratory model to potential responses in perimenopausal women, who are subjected to fluctuations in E2/progesterone ratio resulting in relative increase in E2 level due to progressive decline in secretion of PRG by corpus luteum (21).Even without caffeine, Maca can help increase stamina, reduce fatigue, and boost physical endurance.The mechanism for the observed increase in AR and NADPH-d positive neurons in the present study is probably due to the androgen increasing property of T.For Maca-GO to exhibit its significant hormone-balancing and therapeutic effect, it was essential to use it continuously during two consecutive months.Maca root has been used to make medicine that’s taken for infertility, health problems due to menopause and low sexual desire, per the U.S.Lepidium meyenii (Maca) enhances the serum levels of luteinising hormone in female rats.Ismail et al. (45) reported a total of 31 adverse events, with all of them being assessed as unlikely related to the treatment. According to Chacon (1) and Muller (5), Maca works in an entirely different way for most women than phytoestrogen herbs (like black cohosh and licorice root) or HRT, by promoting optimal functioning of the hypothalamus and the pituitary, thereby improving the functioning of all the endocrine glands. Maca has been recognized by natives of Peru as herbal remedy helping to treat conditions affecting menopausal women. With the right choice, maca-infused coffee can be a valuable addition to a proactive men's health routine. Claims must avoid implying medical benefits (e.g., 'treats ED' or 'cures low testosterone'). While the studies sound promising, Streicher points out that they’re small and done over shorter periods of time, making it hard to draw big conclusions from the findings. But maca also is getting attention because it’s a “natural” product, says Dr. Lauren Streicher, a clinical professor of obstetrics and gynecology at Northwestern University’s Feinberg School of Medicine. Maca is a root vegetable that’s native to Peru. Those are some big claims for one supplement, and it’s fair to have a healthy dose of skepticism. Adding Maca Root to Your Diet: Practical Tips and Recipes Maca is a plant root known for its potential to balance hormones, improve sexual function, boost energy, and more. If you experience positive health benefits then we suggest you continue treatment at that ideal dosage. To learn about using maca to balance hormones click on our treating hormonal imbalance with maca page. Unlike other hormonal specific botanical treatments maca does not contain phytoestrogens and does not directly stimulate oestrogen production. The aim of this review was to assess the clinical evidence for or against the effectiveness of the maca plant as a treatment for sexual dysfunction. A multivariate analysis via the canonical variate technique (14) was used to relate 21 (GMS) or 11 (KMI) response variates to groups of menopausal women treated in various sequence combinations of Maca-GO & placebo treatment. Significant differences were tested using the least significant difference (LSD) at 5% level.A multivariate analysis via the canonical variate technique (14) was used to relate 21 (GMS) or 11 (KMI) response variates to groups of menopausal women treated in various sequence combinations of Maca-GO & placebo treatment. In this double blind, randomized, coordinated multi-centre, outpatient study on 66 early-postmenopausal women, an attempt was made to determine the effect of Placebo administered intermittently with Maca-GO (Placebo as a resting period from Maca-GO treatment), on the degree of womens’ responses to Maca-GO administered in various monthly intervals during the four month treatment program. All participants agreed to four, monthly “in-clinic” visits (at admission and then after each month of the treatment) to be physically examined by the Gynecologist, with blood sampling for hormone analysis and a simultaneous interview with the Gynecologist to assess their menopausal symptoms according to questionnaire by Greene (GMS) and Kupperman (KMI). This trend has not confirmed earlier pilot observations on postmenopausal women (7) where levels of both E2 and PRG significantly increased with simultaneous decrease in Follicle Stimulating Hormone (FSH) level. Although it could not be statistically tested in this study, it may be assumed that different responses to Maca-GO treatment may be confounded by differences in dietary habits amongst populations linked to two regions and groups of women participating in the study (preference for potato-based dishes with fewer leafy vegetables in Poznan and pasta or rice with more leafy vegetables and fruits in Glogow). Comparing degree of statistical significance in influences of Maca-GO on KMI and GMI in terms of detected reduction in frequency and severity of menopausal symptoms, it appears that KMI is more sensitive in displaying the effect of both Placebo and Maca-GO treatments on the recorded scores of menopausal tests as compared to GMS (Table 7). There was a distinctive effect of the length of Maca-GO treatment on the degree of reduction in severity of individual symptoms, with two months of treatment magnifying the positive results already observed after one month of treatment. Positive effect of soy and red clover extracts is attributed to action of flavonoids with biochemical structure resembling steroids in human hormones (20) and may induce some side effects similar to those observed after synthetic hormones are used. Within the above range up to 15 g Maca-GO per kg BW (the highest dose possible to be applied in the study), no detectable negative physiological, clinical, histo-pathological, nor toxic effects existed which could be attributed to the used doses of Maca-GO and administered to rats and/or mice during model laboratory bioassays (9). John’s story is just one example of how maca can positively impact the lives of those with Type 2 diabetes. Take John, for example, a 54-year-old with Type 2 diabetes who started adding a teaspoon of maca powder to his morning smoothie. While scientific research is crucial, personal stories can provide a unique perspective on how maca might help manage Type 2 diabetes. Look for high-quality, organic maca powder from a reputable source to ensure you’re getting the purest form without any additives or contaminants. The improved energy levels and reduced fatigue can lead to more productive workouts and better strength gains over time.One study found that maca can improve sex drive in women prescribed with antidepressants (which are known to decrease a woman’s libido).Having over 20+ years of experience in bodybuilding, helped many individuals to get jacked by different steroid cycle.These benefits may stem from Maca’s influence on the hypothalamus and pituitary glands, which regulate sexual arousal and function.And commit to taking the supplement for a couple of months.The skepticism towards the concept of aphrodisiac is not unjustified, although a systematic evaluation and compilation of scientific information may provide a basis for the evidence-based utilization of herbal drugs for treatment of sexual dysfunction in general.The paired samples t-test was used to assess changes in serum testosterone from baseline to endpoint for each treatment arm. One of the easiest ways to incorporate maca into the diet is by adding a teaspoon of maca powder to smoothies. In men, maca may positively influence sperm production, motility, and quality. This may be attributed to maca's potential to support the secretion of nitric oxide, a molecule involved in vasodilation (39). Maca root is rich in essential nutrients that support a well-functioning endocrine system. Inadequate intake of high-quality fatty acids, proteins, vitamins, and minerals may contribute to hormonal imbalances. In humans, although maca does not affect serum levels of LH, FSH, prolactin, testosterone, or estradiol in men (4) (9), it appears to modulate some hormone levels in women in some studies (24) (26) but not others (25) (27). Further research, informed by the results of the current study and specifically designed to focus on endocrinologic measures, is required in order to fully examine maca root as a treatment for women with AISD. Of note is the finding from a previous study that postmenopausal women treated with maca were more likely than those who received placebo to show significant decreases in FSH and significant increases in LH production . This is, to our knowledge, the first double-blind placebo-controlled study to examine the efficacy and safety of maca as a treatment for antidepressant-induced sexual dysfunction in women. Longifolia supplementation to enhance testosterone levels, particularly in those men suffering from hypogonadism. Furthermore, Egger’s and Begg’s tests revealed significant levels of publication bias among studies included in the hypogonadism group (Supplementary Table S1). Average net change in serum testosterone levels of men supplemented with Eurycoma longifolia. Henkel et al. and George et al. did not observe any change in dehydroepiandrosterone levels after treatment 30,32. ✲ Some small data sets have indicated that it increased testosterone production in the Leydig cells of lab animals. ✲ There is no hard data, however, that Maca has any influence, direct or indirect, on testosterone levels or production in men. A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen. Some reports have shown that maca may increase blood pressure in those with metabolic syndrome. Maca root is sold in powder, capsule, tablet, and extract forms. The swimming time to exhaustion was measured to investigate if maca had the antifatigue property in middle-aged mice. The images of protein-antibody interaction were captured with the Odyssey infrared imaging system (Li-Cor Bioscience) and analyzed with Image J with normalization to the loading control β-actin. Equal amounts (30–45 μg) of total protein extracts were separated by 10–15% SDS-PAGE and the separated proteins were transferred onto nitrocellulose membranes. Swimming endurance capacity was assessed according to a previous study with minor modifications. Then motor coordination was assessed with a rotarod treadmill (San Diego Instruments, San Diego, CA, USA) according to a previous study with minor modifications. In general, improvements in daily sperm production can be seen from day 1 of supplementation in rats and improvements in sperm count can be seen independent of increased daily sperm production. In regards to spermatogenesis, it has been reported that Black Maca has more beneficial effects on spermatogenesis relative to Yellow and Red as the increase in daily sperm production seen with Yellow and Red sometimes fails to reach statistical significance. An increase of testosterone in these rats are not seen with Maca, which is normally the result of 5α-reductase inhibitors such as Finasteride or Fenugreek, suggesting no interaction on the level of the 5-AR enzyme. Some practitioners recommend cycling maca, taking it for three weeks, then pausing for one week to prevent desensitization and allow the body to maintain its hormonal rhythm. Both men and women report increased libido, better sexual function, and improved satisfaction after taking Maca regularly. One of the earliest traditional uses of maca root was as a natural energy enhancer. This makes Maca root a popular natural remedy for those dealing with conditions like PCOS, endometriosis, and perimenopausal hormone shifts. Experts highly believe the benefits would be similar in women. In the present, modern men and women choose maca to improve their stamina during workouts. These fatty acids have been shown to increase sexual activity among animals. More research is taking place right now, as we speak, and is expected to yield positive results in proving maca’s wonderful effects. The HG in the AEM-H group increased significantly and the level of LDH increased in both the AEM-H and AEM-L groups. Related studies have reported that SDS might change the course of HG and LDH, which were related to fatigue. Increased ATPase activities in liver tissues may be one mechanism by which Maca increases heat production. Q2: Can Maca extract really improve muscle strength? Throughout the centuries, the maca plant has had to adapt in order to survive these challenging growing conditions and environmental stressors. Peruvian maca is grown locally in the high elevations of the Andes, in extremely harsh conditions and temperatures. I was on a healing journey of sorts, traveling the globe, trying to find natural – yet proven – solutions to my own hormone nightmare…going into premature menopause at the age of 39 due to a personal trauma. Let’s talk about that and I’ll also give you some insights as to why I chose maca as the cornerstone ingredient in my superfoods blend. And what does the research say about this ugly little root? However, a recent study did demonstrate that maca did not affect any phase of either the estrous cycle, number of ova recovered within oviduct, serum estradiol levels, wet uterine and body weights as compared with a placebo control group. One study on perimenopausal women showed that maca use significantly alleviated perimenopausal symptoms (such as hot flashes, depression, and sleep) by 74%-87%. His particular focus has been on maca and he has been involved in numerous studies exploring the individual health benefits of different maca colours on both rats and people. We are currently developing a larger follow-up study to examine the efficacy of maca root in women with AISD. In this double-blind, placebo-controlled, follow-up study, remission rates of sexual dysfunction by the end of treatment were higher for the maca than the placebo group. In addition, aqueous extract of black maca has been reported to improve experimental memory impairment induced by ovariectomy via downregulation of oxidative stress . In this study, the mice in MACA showed better learning and memory ability as assessed by the Morris water maze test, suggesting the potential of maca for preventing cognitive decline in the elderly. Rubio et al. reported that aqueous and hydroalcoholic extracts of black maca improved memory deficits in mice induced by ethanol, scopolamine, or ovariectomy, respectively 9–11. In the present study, we demonstrated that five weeks of maca supplementation improved cognitive function in middle-aged mice. The protein levels of oxidative phosphorylation (OXPHOS) enzyme complexes have been used as indicator of mitochondrial metabolic function in previous studies 32–37. Because of this, the supplement appears to work mainly by influencing hormone balance. These ingredients support blood circulation, hormone balance, and long-lasting energy. The formula contains herbal and botanical extracts instead of synthetic chemicals. Rather than working instantly, it focuses on helping the body improve naturally over time. It was even observed that the epidermal thickness measurements treated with 15% aqueous extract were similar to those that were not exposed to UV-B radiation (Castañeda-Alarcón et al., 2021). The climatic conditions in which maca plants usually develops leads to a potential photoprotective effect, which was evaluated in vivo in mice exposed to irradiation with ultraviolet B (UV-B) rays. On the other hand, the in silico analysis exposed the possible coupling mechanisms; compounds glucotropaeolina, β-carboline alkaloids, succinic acid and 2,4-dihydroxy-3,5-cyclopentildienoic acid showed greater affinity for the active site of ACE, whereas macamides showed greater affinity for the active site of renin (Ibrahim et al., 2022; Harvey et al., 2024). In the in vitro tests, the methanolic extract showed the greatest inhibition of angiotensin-converting enzyme (ACE) and renin. Further we intend to explore the hypothesis that the salutary effects of maca on sexual dysfunction derive from an androgenic response. In a prior trial we recently demonstrated that maca treatment may yield improvement in libido in women with AISD . Recently, an interesting case report in the British Medical Journal detailed the case of testosterone assay interference by maca, suggesting that maca contains an as of yet unspecified compound with a similar moiety to the human testosterone molecule and that it may be exerting its androgenic effects through actions at the testosterone receptor on target organs without affecting the level of testosterone or gonadotrophins . For the postmenopausal female population, while the paucity of data precludes any reasonable inference of effectiveness, let alone mechanism of the effect , it is quite possible that maca ameliorates postmenopausal symptoms through an androgenic mechanism. Known as the Peruvian superfood, maca is an ancient plant used by native Andeans.This review provides an in-depth revision and analysis of Maca’s diverse bioactive metabolites, focusing on the pharmacological properties registered in pre-clinical and clinical studies.Maca is a wonderful root vegetable that is native to the high altitudes of Peru.Most of the research on tongkat ali has been related to testosterone production and sexual function.We sought to demonstrate that maca root may be an effective treatment for antidepressant-induced sexual dysfunction (AISD) in women.A structured PubMed search was the performed for “testosterone” and each of the 109 components found in the supplements. Maca Root: Potential Benefits, Known Risks, and More You also want your organic maca to be from Peru versus somewhere else, as that will also ensure it is GMO-free The Peruvian government currently bans GMO in maca harvests. I purchase only certified organic maca for Mighty Maca Plus. First, only buy organic Peruvian maca, and I suggest you also look for organic certification on the label. Illustrating this, a 2017 case report described new-onset, bilateral pulmonary embolisms secondary to over-the-counter fenugreek-extract-containing T supplements . There is often the hope that supplements will increase T in a more “natural” manner, and therefore be free from risk. Herbal supplements designed to increase T are poorly studied yet remain popular among aging men who seek to increase their T without standard TRT. TRT has a well-defined risk profile, with clear guidelines for indications, contraindications, dosing, treatment goals, and monitoring during treatment . At the same time, body weight and blood pressure were checked and blood was sampled for hormones and other biochemical analyses. The trial was of a double-blind, placebo-controlled, crossover design and randomization of treatment allocation was performed in blocks of two with the block details unknown to the investigators. Hard gel capsules both placebo and Maca-GO (500 mg net per capsule), used in this study were custom-manufactured at the Research Institute of Medicinal Plants in Poznan. Such treatment of Maca, without any chemicals used in the process, resulted in the final powdered product (Maca-GO) achieving increased density and through pre-gelatinization of a starch component in the product (not less than 98% according to BRI Laboratory assay, Sydney, Australia), expected to promote its easier digestion and bio-availability. It was reasonable to suppose that Maca-GO may be of value in alleviating perimenopausal symptoms as a potential substitute to HRT, or reducing dependence on HRT programs. However, more research is needed to fully understand the effects of maca on the body. Today, maca is widely consumed in Peru and has gained popularity around the world for its potential health benefits. The root of the plant is the part that is used for its various health benefits. Additionally, maca may help improve mood and reduce symptoms of anxiety and depression, which can also impact sexual function. Studies have shown that maca can improve sexual desire and performance in men, as well as increase sperm count and motility. If you develop symptoms of liver damage, stop taking the supplement and speak to your doctor. It can be difficult to know whether the effects are due to ashwagandha itself or another contaminant. Most supplements come in the form of 500mg capsules, with BioPerine (black pepper extract) which is thought to aid absorption. Only 1 study demonstrated positive effects of Asian ginseng supplementation on testosterone (47), while 6 studies showed no effect of supplementation (Table 1). The main findings of this review indicate that 2 herbal extracts, fenugreek seed extracts and ashwagandha root and root/leaf extracts, have positive effects on testosterone concentrations in men. From a set of clinical tests conducted on laboratory rats, we have data showing that Maca increased the level of testosterone in the Leydig cells (hormone producing cells in the testes). However, many studies suggest that maca may have anti-hypertensive effects in healthy adults (2). Maca root is thought to support hormonal regulation, libido, and sexual function in both men and women. Researchers have explored its pharmacological properties and have identified bioactive compounds that may contribute to its effects. The first applied the oral administration of micropulverized fresh maca capsules for 60 days in doses of 1.5 g/day. One of them used oral administration of maca capsules for 12 weeks in patients using selective serotonin reuptake inhibitors (SSRIs). Five studies were randomized, double-blind, placebo-controlled trials (42, 57, 58, 63, 64) and one was a randomized, double-blind, placebo-controlled crossover study (53). This outcome was similar to that of an 8-wk study in 143 men (33–79 y) with erectile dysfunction, using a slightly higher dose (2 g/d) of tissue-cultured mountain (Asian) ginseng (root) extract (49), as well as another study using a longer intervention (12 wk, 3 g/d, Korean red ginseng; details of extract preparation not provided) in 60 men (26–70 y) with mild-to-moderate erectile dysfunction (37). Six studies used a randomized, double-blind, placebo-controlled study design (36–38, 47, 49, 56), and 1 study used a randomized, controlled crossover study design (65). All studies used berry or root extracts of Asian ginseng (Panax ginseng), with the root reported as Korean red ginseng, a processed form (67). Observations made in the pilot clinical study reported here justify further more complex study on use of Maca in perimenopausal women. Obtained results and available literature evidence may suggests that Maca-GO, when taken in a right dose is acting as a toner of hormonal processes which may alleviate discomfort felt by women during perimenopausal stage. Research evidence available from some North American and English scientists who were studying the pathologies of people living at high altitudes of Andes (at about 4,000 meters), characteristic to the altitude, where those people cultivating Maca live, show that women residing there, had no postmenopausal problems (5). In the USA health care practitioners increasingly integrate herbal therapies into their medical practice and amongst of phyto-preparations they recommend, Maca by now, is becoming an available alternative to prescription drugs for effective relief of menopausal symptoms (4). For those women who still had some symptoms, a combination protocol involving Maca extract and a minute amount of natural estrogen together with natural progesterone is suggested, which, unlike progestin, is considered not carcinogenic. For example, a 2007 study published in the journal Andrologia found that men who took maca supplements for eight weeks had increased sexual desire compared to those who received a placebo.If it’s working well for you, then you can increase your dose accordingly.To be enrolled in the study, patients had to have been taking an SSRI, venlafaxine, or a tri/hetero cyclic antidepressant for the treatment of depression at a stable dose for at least 4 weeks.This fact has led many to the consensus that black maca is better suited for men, while red maca is better for women.Prioritize organically grown, Peruvian-sourced maca—preferably gelatinized for better absorption—and verify third-party testing whenever possible.The varying levels of anthocyanin, some of its plant compounds, are primarily responsible for the color differences in the root."Some claims are over the top -- compared to a placebo, maca only slightly enhanced sexual desire. The strongest evidence is that it may increase sperm count and improve fertility in certain men," she says.TRT is a well-established treatment option for those with symptomatic T deficiency. The Hormone-Balancing Diet for Menopause: 15 Foods That Fight Hot Flashes & Fatigue The hardy root is also packed with minerals, including iron, zinc, iodine, calcium, copper, magnesium and potassium. The maca plant belongs to the brassica (mustard) family and like broccoli and cauliflower, is a cruciferous vegetable. If you asked the ancient Incas to name their ‘go to’ superfoods, maca would have been top of the list. There does not appear to be a noticeable difference between red, black, and yellow maca when it comes to libido. Encouragingly, researchers observed increased sexual desire scores plus elevated seminal volume and sperm motility. – Reliably increases animal sexual behaviors However, proof remains controversial whether maca also amplifies testosterone in human males rather than just enhancing libido via other means. In the Pilot Bone Density Observation, two participants from Placebo group and one from Maca-GO group have not completed the four months study as they failed to take their daily doses of capsules and therefore, they were excluded from the analysis of data. A multivariate analysis via the canonical variate technique (9) was used to relate 21 (GMS) or 11 (KMI) response variates to groups of menopausal women treated in various sequence combination of Maca & Placebo treatment. Significant differences were tested using the least significant difference (LSD) at 5% level.A multivariate analysis via the canonical variate technique (9) was used to relate 21 (GMS) or 11 (KMI) response variates to groups of menopausal women treated in various sequence combination of Maca & Placebo treatment. At the start and then on completion of each monthly interval of the study, all women were interviewed by the gynecologist and requested to answer a set of standard questions according to questionnaires designed by Greene (menopausal score) and Kupperman (menopausal index). Two groups of 6 women (M and P) were involved in a forearm bone density observation, together with levels of blood FSH and E2 recorded at the admission point and at the time of bone density scanning four months later. Figure 1 also shows that the participants from the three groups (APMM, AMMP and APPM) were clustered separately by the canonical variate analysis even before the treatments were administered. After the fourth month of the study, hot flushes remained the highest coefficient of the 1st canonical equation, followed by heart palpitation (Table 8). Group APMM was separated from AMMPM and APPMM by the first canonical variate after one month of study, while Group AMMPM was separated from APPMM by the second canonical variate. One study examined the ability of black, red, and yellow maca to support energy levels. In men, maca root may support sperm quality and count and help protect against oxidative stress. In women, maca may help regulate progesterone and estrogen, which could support healthy libido, fertility, and menstruation. Most studies used much lower doses, possibly explaining the lack of changes in serum testosterone levels (2). For women, Maca has been shown to also improve sexual function and libido, proving that as an aphrodisiac maca powder benefits both sexes. While not directly influencing testosterone levels, maca acts on the endocrine system, which may result in better regulation of hormonal levels including testosterone and estrogen. Maca root, a revered food and supplement, holds a wealth of nutritional benefits that may particularly interest you as a man, including its role in sexual health, energy, and physical performance. “People have reported side effects including headaches, GI upset and jitters,” Wider says. Maca root is generally considered a safe supplement, but there are potential downsides to using it. “There are properties of the root that may be beneficial, but we do not have testing that’s adequate right now.” If you have thyroid issues, you should monitor them when you start taking maca to see if it causes any changes. Having worked with over 2000 women, we consistently hear stories about a reduction in hot flashes, night sweats, depression, insomnia, nervousness and anxiety, as well as improved concentration. As a result, maca helps prevent you from getting stuck in the adrenal exhaustion stage. It kick-starts a cascade of stress hormones including adrenaline and cortisol. TRT is a well-established treatment option for those with symptomatic T deficiency. For 27 individual supplements (24.8%), there was data showing an increase in T with supplementation. For 13 supplements (11.9%) there were 2 studies; for 3 supplements (2.8%) there were 3 studies; for 4 supplements (3.7%) there were 4 studies; for 1 supplements (0.9%) there were 5 studies; for 1 supplements (0.9%) there were 6 studies. For 19 supplements (17.4%) there was a single study looking at the effect of supplementation on T. The claims and the number of supplements claiming these benefits are detailed in Table 2. For men specifically, maca may help maintain healthy ratios between testosterone and estrogen.One study tested a range of semen parameters on nine men taking 1,500-3,000 mg over four months.Meanwhile, a number of animals studies involving mice and rats point to maca enhancing endurance performance.Throughout history, the Peruvians do not appear to have utilized these maca varieties for their individual benefits.However, a recent study did demonstrate that maca did not affect any phase of either the estrous cycle, number of ova recovered within oviduct, serum estradiol levels, wet uterine and body weights as compared with a placebo control group.The majority of women, who after Placebo run-in period received Maca-GO capsules, recorded highly significant (P6).This article delves into the heart of this fascinating root, exploring its history, the science behind its hormonal balancing prowess, and its benefits for both men and women.However, these results are independent of any changes in testosterone and estrogen levels. Amongst a variety of traditional applications, Maca has been used for years by the native people of Peru as an energizing vegetable for maintenance of health at high altitudes in the Andes and as a dietary supplement. This study was conducted and jointly supported by a long-term joint R&D program of the Research Institute of Medicinal Plants (RIMP) in Poznan, Poland and School of Health Study, Charles Sturt University & Therapeutic Research International, Sydney, Australia on medicinal plants and therapeutic preparations originating in Australasia, Oceania and South America. Remembering that Maca-GO itself, does not contain any hormones (2, 12-14, 28), the action of Maca hypocotyls, traditionally is linked to its coherent and unique complexity of integral active constituents such as alkaloids, sterols, glucosinolates, amino acids, fatty acids, minerals and others yet to be established (8, 29, 30). In addition, benzyl isothiocyanate present in Maca root has been reported to be a potent cancer inhibitor of mammary gland and stomach (31). According to Dini (28), reported in the literature, the aphrodisiac powers of Maca for men and women, may be ascribed to the presence of prostaglandins and sterols in the hypocotyls of Maca and overall fertility enhancing properties may be attributed to the presence of biologically-active aromatic isothiocyanates derived by hydrolysis of the glucosinolates and specifically due to benzyl isothiocyanate and p-methoxybenzyl isothiocyanates (29, 30). It was also observed that it promoted the differentiation of TAMs causing the increase of pro-inflammatory factors (IL-12, TNF-α, INF-γ, iNOS) and the decrease of anti-inflammatory factors (IL-10, MMP9, VEGF) (Guo et al., 2020). Aqueous and polysaccharide extracts were shown to regulate the inflammatory response by increasing the expression of proinflammatory cytokines (IFN-γ, TNF-α, IL-2) and decreasing the expression of IL-4 (Fei et al., 2020; Fei et al., 2022a); while the hydroalcoholic extract showed an immunostimulatory effect on the humoral response to produce more post-sensitization antibodies (Alvarado et al., 2022). The MC-2 polysaccharide from maca induced differentiation to type 1 macrophages (M1), known for their proinflammatory activity, increasing the expression of proinflammatory markers (IL-6, iNOs). You may want to start at a lower dose — 1.5 g — to see how your body reacts before increasing your dose. Doses of up to 3 g per day for up to four months appear to be safe. It's a root vegetable that belongs to the radish family. It can help combat symptoms of depression by increasing the production of neurotransmitters like serotonin. This can be especially beneficial in today's fast - paced world where stress and anxiety are common mental health issues. This can have a positive impact on the sexual relationships of individuals, leading to a more fulfilling sex life. Testosterone is an important male hormone that is involved in muscle building, bone density maintenance, and libido. The mechanism for the observed increase in AR and NADPH-d positive neurons in the present study is probably due to the androgen increasing property of T. Terrestris administration in rats increased the NADPH-d positive neurons and androgen receptor immunoreactivity in the PVN region. There was an improvement of the sexual behaviour parameters as evidenced by increase in mount frequency and intromission frequency; decrease in mount latency, intromission latency, and penile erection index 101, 102. Terrestris extract showed increase in prostate weight and intracavernosal pressure. Terrestris has long been used in the traditional Chinese and Indian systems of medicine for the treatment of various ailments and is popularly claimed to improve sexual functions. Additionally, some research suggests benefits for mood and mental clarity, which further broadens its appeal beyond just physical performance. Unlike stimulants such as caffeine, maca provides sustained energy without jitteriness, making it appealing to athletes, busy professionals, and aging men alike. The most common forms available include raw powder, gelatinized powder, capsules, and liquid extracts, each varying in potency, digestibility, and intended use. On the basis of the obtained results, adopting recommendations by Hodge and Sterner as per the OECD (22), the LD50 for Maca-GO for oral applications was established as 15 g/kg body weight – a way above the OECD 2 g/kg limit. Ovariectomized rats which were administered Maca-GO had less entries into lit area of maze with more frequent and longer stay in darkened area which may be linked to sedative effect of Maca-GO on ovariectomized rats, with no such effect being observed in non-ovariectomized rats. Statistically significant (P48 showing a decline in long-term (after 48hr) cognitive functions in ovariectomized rats, as compared to rats with intact ovaries. Similar results were obtained in an anxiolytic test with the use of a “plus-maze test” in which ovariectomized rats significantly (PP5). Letters preceding the values in columns for consecutive blood sampling points within the individual hormone, indicate hormone level as recorded after one month of treatment with either Placebo (P) or Maca-GO (M) within the relevant four treatment sequences analyzed in this Trial.Food intake can modulate absorption; high‑fat meals tend to increase L‑arginine uptake but may attenuate yohimbine's peak levels.This is particularly problematic for people with low thyroid levels and Hashimoto’s.There is significantly increased mounting frequency, intromission frequency, and ejaculation latency and decreased mounting latency, intromission latency, postejaculatory interval, and interintromission interval .This is the second, conclusive part of the clinical study on clinical responses of early-postmenopausal women to standardized doses of pre-Gelatinized Organic Maca (Maca-GO). For the Andean population, maca is considered a valuable commodity and its dried roots can be preserved for years (National Research Council, 1989). Maca’s versatility extends to metabolic regulation, gastrointestinal health, cardio protection, antihypertensive activity, photoprotection, muscle growth, hepatoprotection, proangiogenic effects, antithrombotic properties, and antiallergic activity. Preclinical investigations highlight the benefits attributed to Maca compounds, including neuroprotection, anti-inflammatory properties, immunoregulation, and antioxidant effects. Maca is generally safe, with rare adverse effects, supported by preclinical studies revealing low toxicity and good human tolerance. Maca (Lepidium meyenii), a biennial herbaceous plant indigenous to the Andes Mountains, has a rich history of traditional use for its purported health benefits. Recent data also suggest that the regulation of the gut–brain axis by maca may be one element of its therapeutic mechanisms (Hong et al., 2023). An acute neuroendocrine response to adverse stress stimuli, as that counteract by adaptogens, is characterized by the tripartite activation of the three stress axes including the autonomic sympathetic nervous system, the direct neural innervation of the adrenal cortex, and a cascade of hypothalamic hormonal messengers (Spiers et al., 2015). Meyenii exerts hormonal balancing effect through Maca alkaloids, which act on the hypothalamus-pituitary adrenals (HPA) axis, but this hypothesis has not been confirmed (Muhammad et al., 2002). Unlike synthetic adaptogens, the natural origin as plant extracts has an extremely rich phytochemical composition and physiological properties that are not due to a single one molecule, but to the combination of different compounds (Todorova et al., 2021). Isomerization also produces more isomers of octadecadienoic acid, resulting in the known chemical variety of macamides (Xia, 2021). Life Extension does not provide medical advice, diagnosis, or treatment. Discover nutrients you need for optimal health Krista Elkins has 20 years of experience in healthcare, both as a paramedic (NRP) and registered nurse (RN). However, more research is needed to know if consuming maca during breastfeeding or pregnancy is safe. Maca root powder is generally considered safe. However, it’s crucial to talk to your healthcare provider before starting any new supplement, especially if you have existing health conditions or are taking medications.If you are looking to improve your hormonal profile and increase your physical capacity, then tongkat ali may be the best herb for you.Age effects of follicle-stimulating hormone and pulsatile luteinizing hormone secretion across the menstrual cycle of premenopausal women.But none of these is a miracle cure – at best, any effects are likely to be mild.Women with low progesterone levels or irregular menstrual cycles may find that maca root helps restore balance, reduce PMS symptoms, and improve cycle regularity.In this article, we’ll explore how maca root balances hormones, its benefits beyond hormone regulation, the best ways to take it, and the top supplements to consider.Results obtained in this model laboratory study on Maca-GO are encouraging enough to justify setting up further laboratory and/or clinical study on postmenopausal women to validate positive effects of this preparation as a dietary supplement on human subjects under average everyday situation.One of the most celebrated benefits of maca for men is its potential to enhance libido . Longifolia treatment , which included gastrointestinal symptoms and itching, while Ismael et al. observed adverse events in both treated and placebo groups . Six of the included studies analyzed free testosterone as an outcome 26,29,30,31,32,34, whereas three reported a significant intragroup increase in free testosterone with E. A subgroup analysis was conducted according to the testosterone levels of study subjects. They have a morning-time Maca Coffee Blend, which makes it easy to add maca to your daily routine. As noted in this article, both tongkat ali and maca are excellent herbs that provide a variety of benefits. These herbs may be a helpful combination for increasing libido, hormone production, and energy levels. If you are looking to improve your hormonal profile and increase your physical capacity, then tongkat ali may be the best herb for you. Maca helps to increase libido but does not have the ability to increase testosterone production. Think of tongkat ali as a testosterone-boosting herb that helps to improve physical performance. On the other hand, tongkat ali appears to have the ability to help reduce stress and anxiety levels. It’s thought that maca’s mechanism of action is through its nutrient profile, which is rich in minerals. This can be helpful for athletes competing in sports or individuals that are looking to improve their energy levels and endurance. They come in capsule, liquid, powder and extract form. Maca root is high in vitamins B, C and E – all of which can improve your brain function. Black and red varieties of maca appear to be the most beneficial for the bones. Dry roots were transported to a processing plant at the National Institute of Agricultural Research, National Agricultural University La Molina in Lima, Peru (NIAR), where it was subjected to a gelatinization process followed by drying and pulverizing. According to Muller (6), these sterols are used by the body with the help of the pituitary to improve adrenal function, ovarian and testicular function, as well as the functioning of the thyroid and the pancreas, and the pineal gland. The observed effects on animals were gender and dose dependent, with different responses observed during a short- and a long-term Maca-GO administration (12). The ability of tribulus to increase the release of nitric oxide may account for its claims as an aphrodisiac 100, 102. Terrestris also increased the synthesis of cyclic nucleotides in CCSM cells . Androgens are known to increase both androgen receptor and NADPH-d positive neurons either directly or by its conversion to oestrogen. Physical and mental health are precious treasures. The Maca Team is a small business run by a family who cares about its customers, its Peruvian maca growers, and the environment. ;D The Maca Team’s organic maca is one of them—nine grams in my smoothie, Monday to Saturday. Loving the red maca from themacateam. We hope that you’ve found this article on the many benefits of maca for men helpful. One of the lesser known benefits of maca for men is for reducing depression. Another study showed that regular maca dosage improved stamina among lab mice nearly 20%. In one study, cyclists were able to bring their 40 km times down significantly after just 12 days on maca. Several scientific studies have also confirmed that Maca has a positive effect on endurance and energy levels. Apart from these herbs large numbers of plants have also been tested and evaluated for effect on sexual functions and reproductive parameters, a comprehensive description and names of these herbs are provided in Table 2. This mechanism may constitute one way in which androgens stimulate sexual arousal . NO function as a neurotransmitter and NOS is present in the regions of the brain that regulate sexual functions . Written informed consent was obtained from each enrolled subject regarding voluntary participation in the trial conducted under the supervision of the specialist Gynecologist, who had explained the purpose, benefits and possible risks of the study, its requirements and procedures. Blood levels of FSH, E2, PGR and LH were measured and a degree of menopausal discomfort was determined according to Greene and Kupperman. All voluntarily participating women, after being assessed by a Gynecologist and confirmed on the basis of adopted analytical blood criteria as early-postmenopausal, were enrolled in this 3 month long Trial. As a result of screening procedures in five clinics, a total of 168 participants representing Caucasian, early-postmenopausal women volunteers aged 49 to 58 years were selected. One rat study published comparing acute effects of Maca against chronic dosing noted that, after consumption of 25 or 100mg/kg aqueous extract in mice, that a single dose 30 minute before sexual activity failed to increase mounting or ejaculatory parameters in mice. These aphrodisiac effects also appear to be independent of the ability of Maca to induce locomotor activity, where in a study on rats finding benefits to mounting and intromission latency and the intercopulatory interval (not dose dependent) as well as post-ejaculatory latency (dose-dependent up to 75mg/kg) there was no apparent correlation with the observed increase in locomotion. Most women begin noticing benefits within 2–4 weeks, but significant hormonal changes may take up to three months of daily use. The recommended daily dosage of maca root for hormonal balance ranges from 1,500 to 3,000 mg daily. Women with low progesterone levels or irregular menstrual cycles may find that maca root helps restore balance, reduce PMS symptoms, and improve cycle regularity. You should exercise caution when combining maca root with medications, particularly birth control. Since maca affects hormone levels, it could potentially interfere with normal adolescent development. If you're pregnant, nursing, or have a hormone-sensitive condition, consult your healthcare provider before using maca supplements. Start with a lower dose of 500mg daily and gradually increase it while monitoring your body's response. It’s essential to find the right balance that works for your body. Given maca’s energizing properties, some people may feel jittery or overstimulated. Some individuals might experience stomach upset, gas, or bloating upon consuming maca. Incorporate it into your daily routine, much like any other supplement or vitamin. Its job is to pick up signals from your body and the environment around you and react. Your body’s adaptive response triggers your hypothalamus-pituitary-adrenal (HPA) axis. This means it can directly change the balance of your hormones to help you adapt to stress and illness. Whenever I feel like I need a little afternoon pick-me-up but don’t want to reach for caffeine, this maca formulation offers gentle stimulation that does not interfere with sleep. It was created by a physician and uses maca that is certified organic and sourced from Peru. The risk of bias for each study was assessed using Cochrane criteria, and statistical pooling of data was performed where possible. This study also only utilized a single search term (“Testosterone Booster”). In addition, only the first and most frequently appearing 50 supplements were included in the study, acknowledging that other products and supplements may be available that were not studied here. Limitations of our study are that we used only Google as our search engine, and there may be regional and geographic differences in search engine results.