For example, reasons for 2 of the 6 fenugreek seed extract studies and 1 of the 4 ashwagandha root/leaf studies not achieving significant differences between groups were not discussed. In this systematic review, many studies were underpowered, making it difficult to obtain statistically significant, between-group differences. Similarly, in vitro studies demonstrated reishi's ability to inhibit the activity of 5α-reductase (79, 86, 87). Losing Weight There are, without doubt, plants containing numerous chemicals invaluable for human health that are still waiting to be discovered. They also show anti-inflammatory properties due to inhibition of cellular nitric oxide production. According to some, pulp and peel of ginger rhizomes exhibit in vitro antiproliferative activity against colon cancer cells. With respect to the pronounced antioxidant properties of oleuropein, it protects cells from genetic damage, potentially leading to oncogenesis. To measure food intake, we separated animals in single cages for 7 days. All the diets were provided by Beijing Keaoxieli Co., Ltd (Beijing, China). Fourteen male C57BL/6 mice at 6–7 weeks of age were constructed from Beijing Vital River Laboratory Animal Technology Co., Ltd. (Beijing, China). A nationwide cross-sectional survey of Koreans shows that soybean oil was the major source of PUFAs . It has significant meanings to explore the underlying mechanism and potential treatment of testosterone level decline. Activation of the AR mediates testosterone effects, and both androgens and estrogens regulate AR expression in adult rats 65, 66. Furthermore, chronic treatment with prolactin has been demonstrated to decrease the expression levels of kisspeptin and GnRH in female mice . Moreover, acute hyperprolactinemia has been shown to suppress the synthesis of testosterone and male fertility via inhibiting the secretion of GnRH , which subsequently inhibits LH pulses . After all, many diets stress eating “low fat.” But fat is essential to healthy T levels. The role of healthy fats in testosterone production cannot be overstated. The relationship between dietary fat and testosterone production has been well-established in various studies. These fats are known for their heart-healthy benefits and can help lower LDL (bad) cholesterol levels. Given the importance of testosterone in overall health, it’s crucial to understand how dietary choices, including fat consumption, can influence its production. As long as you don’t have any allergies, eggs are a nutritious and healthy food that can benefit your health. This element has been linked to the production of testosterone in animals, making it an excellent source of testosterone in the morning. Berries and pomegranates, in particular, contain flavonoid antioxidants that protect testosterone-producing cells and speed up the formation of testosterone. Eight weeks of daily supplementation with 2.4 g of a cordyceps extract in 16 healthy men aged between 19 and 25 y did not significantly increase testosterone concentrations compared with the placebo group. Twelve weeks of daily supplementation with 1.0 g of a musali extract in 40 healthy men, aged between 20 and 40 y, did not significantly increase testosterone concentrations compared with the placebo group. Three of the 4 studies demonstrated positive effects of ashwagandha supplementation on testosterone concentrations in men (35, 50, 62), while 1 study (51) showed no effect of supplementation (Table 1). The 2 studies that showed no effect of fenugreek supplementation on TT concentrations (57, 63) recruited healthy men, with participants in the Rao and Grant (57) study including men with benign prostate hyperplasia (BPH). Four of the 6 studies demonstrated increased testosterone concentrations with fenugreek supplementation (42, 53, 58, 64), while 2 studies (57, 63) showed no effect of supplementation (Table 1). This may include men wanting to improve their reproductive potential or athletes wishing to improve their athletic performance, not only through testosterone long-term anabolic actions but also through its rapid effects on behavior . Carbohydrate intake, at least in the form of highly antioxidant OJ, had very minimal impact on serum testosterone. However, we believed this to be unnecessary, as a number of other research groups have reported no statistically significant changes in SHBG levels after the consumption of a mixed meal , a high-fat meal 20,40 or a refined carbohydrate meal . Omega-3 plus capsules were purchased from the SEDICO Company (Cairo, Egypt) and were 1000 mg fish oil soft gel capsules containing 13% EPA and 9% DHA. Thus, the synthesis of sex steroid hormones and the resultant male fertility could be influenced by the activity and/or expression of testicular steroidogenic enzymes. 17α-hydroxylase/17, 20-lyase (CYP17A1), converts progesterone into androstenedione, which is converted to testosterone by 17β-hydroxysteroid dehydrogenase (17β-HSD), and testosterone is converted to estradiol by aromatase cytochrome P450 (CYP19) . Thirdly, polymorphisms related to drug-metabolizing enzymes and transporters can lead to significant differences from individual to individual in the bioavailability of the phenolic compounds taken with EVOO, representing a further issue when translating scientific evidence obtained in vitro into in vivo studies . Firstly, it has been observed that doses compatible with the human diet are hardly ever tested in in vitro investigations, but tested concentrations are actually often higher and not to a small extent. Various factors may contribute to the unfruitful translation of the biological effects pointed out in vitro to human trials. Especially tell your healthcare provider if you take insulin, medicines that decrease blood clotting (blood thinners), or corticosteroids. Inform your healthcare provider of all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Before using Male Excel’s Testosterone Lipoderm Cream, inform your healthcare provider about all of your medical conditions, including if you have breast cancer, prostate cancer, urinary problems due to an enlarged prostate, heart, kidney, or liver problems, or problems breathing while you sleep (sleep apnea). Early signs and symptoms of puberty have occurred in young children who have come in direct contact with testosterone by touching areas where men have used Male Excel’s Testosterone Lipoderm Cream. Semen quality, measured as volume, concentration, total sperm count, percentage of morphologically normal spermatozoa, and motility, and serum reproductive hormone levels, measured as follicle-stimulating hormone, luteinizing hormone, testosterone, free testosterone, and inhibin B levels. If you are having issues with fatigue, low libido, erectile dysfunction, decreased muscle mass, or difficulty losing weight, low testosterone may be the culprit. A good night's sleep is vital for hormonal balance, including testosterone production. The same applies if you notice increased acne in a woman that may have happened through accidental touching of the area where you have applied Male Excel’s Testosterone Lipoderm Cream. Stop using Male Excel’s Testosterone Lipoderm Cream and call your healthcare provider immediately if you see any signs and symptoms of puberty in a child or changes in body hair. The men stated whether they used vitamins or dietary supplements within the last 3 months. The men were asked about their frequency of smoking tobacco or marijuana (ie, daily, occasionally, or never) in the last 3 months and intake of alcoholic beverages during each day of the past week. This included information on previous or current health conditions and genital conditions, such as inguinal hernia, varicocele, epididymitis, and having undergone a surgical procedure to treat testicular torsion. The study has been ongoing since 1996, but in 2012 the questionnaire was revised to include information on nutritional supplements.17 This study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline. On the day of study participation, they delivered a semen sample, had a blood sample drawn, and underwent a physical examination. Summary of randomized controlled trials examining the effects of herbs on testosterone concentrations in men1 Given the increasing body of research on herbal supplementation to support natural hormone production, it presents as a potential treatment option for AD. Despite TRT being the primary treatment for men with AD, its use remains controversial due to its association with an increased risk of exacerbating pre-existing medical conditions. This systematic review includes randomized controlled trials examining the effects of herbs, spices, plants, and their extracts on testosterone concentrations in men. One factor that can significantly influence testosterone levels is the consumption of dietary fats. While it is unlikely to single-handedly elevate testosterone levels significantly, raw honey can be a valuable addition to a well-rounded diet aimed at optimizing hormonal health. Yes, raw honey can play a role in supporting healthy testosterone levels. This decline has led many men to seek natural methods to support healthy testosterone production, including dietary and lifestyle changes. They contain lots of zinc and Vitamin D, which help to increase testosterone. All these elements promote testosterone production. Nuts contain a lot of monosaturated fats, zinc, Omege 3 fatty acids, and protein. It plays a key role in developing their reproductive organs and other sexual features such as body hair and muscle mass . To accomplish this contribution, we searched the Scopus, Web of Science, and PubMed databases for full articles or abstracts (published in English language) from April 1967 through December 2018 using the keywords “onion” versus “testosterone”. Examples of such research approaches is to utilize specific types of food or dietary supplements as a safe and easily reached means. Maintaining and enhancing testosterone level in men is an incessant target for many researchers. To lose weight healthily, you need to reduce your daily calorie intake by 500 to 1000 calories so that in a week you can lose 1 to 2 pounds, which is a healthy rate to lose weight. The effects of less sleep were more evident from 2 pm to 10 pm when they had the lowest levels of testosterone. From the results, it was seen that their testosterone levels were low after a night of sleep restriction compared to the nights when they got sufficient sleep (2). Blood samples were taken regularly so that they could track their testosterone levels. Do you have to increase your levels of testosterone? The inclusion of the testosterone fractions and binding proteins were deemed important since only ∼2% is “free” testosterone, with the remaining testosterone “bound” to proteins (predominantly SHBG, ∼40–45%) (31–33) and controversy existing regarding the relative importance of “bound” and “unbound” testosterone (34). These included TT, (calculated) free testosterone (FT), measurement of FT, bioavailable testosterone (BT), and sex hormone–binding globulin (SHBG). Risk of bias of the included studies was assessed using the Cochrane Collaboration's tool for assessing the risk of bias in randomized trials (30). Each study was scored based upon its risk of bias being low, with some concerns, or high for each criterion. The reference lists of relevant papers were also examined to locate additional studies that were not identified by the initial database search. According to a study from ScienceDirect, testosterone production may be boosted by high intakes of monounsaturated fats such as those found in olive oil, avocados, and nuts. Oils high in PUFAs and omega-6 fatty acids, such as soybean, corn, and sunflower oils, are more likely to negatively affect testosterone compared to oils like olive oil or coconut oil. While some PUFAs are essential for health, excessive consumption of omega-6 fatty acids has been linked to decreased testosterone levels. Several studies have investigated how vegetable oils affect testosterone levels, and the results suggest that certain types of vegetable oils may have a negative impact on testosterone production and balance. As the consumption of vegetable oils has increased dramatically in modern diets, it’s essential to explore how these oils may impact testosterone production and balance. A Mediterranean-type diet, which includes fruits, fish, vegetables, legumes, whole grains, healthy fats, and oils, has been shown to improve male fertility (Guasch-Ferré and Willet, 2021; Salas-Huetos et al., 2019b). Another study conducted on young athletes in 2017 (Wilson et al., 2020) showed that following a ketogenic diet led to increased total testosterone levels compared to a Western-style diet. Our findings indicate that men who adhere to the Mediterranean diet and reduce their carbohydrate intake experience lower sperm DNA fragmentation and increased testosterone levels. The monounsaturated fat and vitamin E content in extra virgin olive oil can help to increase a person’s overall fat intake, promoting testosterone production. Now Offering: PSMA PETCT Scans for Prostate Cancer Bananas also contain high amounts of B-Vitamins, which improve zinc absorption and thereby increase testosterone as well. Citrus fruits are rich in Vitamin C, which helps to lower the “stress hormone” cortisol and, thereby, increases testosterone. By reducing cortisol, testosterone in your body will be more effective. 5′ AMP-activated protein kinase is an enzyme (heterotrimeric protein-complex) plays a vital role in energy homeostasis in cellular systems; specifically, by enhancing fatty acids oxidation and glucose uptake . Enhancing nitric oxide, a free radical gas generated by nitric oxide synthase and acts as a vasodilator, may increase blood flow in the testis and promote testosterone synthesis . Collectively, according to these evidences, it can be suggested that the hypoglycemic effect of onion has a positive effect on testosterone production, particularly in diabetic conditions. It was demonstrated that that onion has hypoglycemic effects and can be used as a dietary supplement to manage the progression in patients with type 1 and type 2 diabetes . How Do Vegetable Oil Lower Testosterone Levels? (Science-Based) Even worse, the effects can be dose-dependent (43)—the more you drink, the more your testosterone and sperm production is likely to suffer. However, the findings indicate that both onion and onion extract has a positive effect on testosterone levels. Research on boron’s ability to jack up T levels is mixed, but in one study, boron was found to influence testosterone metabolism and protect against T degradation (34). Avocados also contain boron, a mineral that may benefit testosterone levels. This is common in bodybuilders when they’re prepping for a show who achieve drastically low levels of body fat (hovering around 5%). More successful people tend to have higher testosterone levels, so success and testosterone are positively correlated. It also has an array of other benefits, one of them being increased HGH (human growth hormone) and testosterone (43). Frequent masturbation can lower your testosterone levels by reducing your androgen receptors in your brains (40). Research shows that competition also seems to spike testosterone levels (36). Would using castor oil as the carrier be the best option? And would it be better to diffuse this into to air or apply it directly with a carrier oil? This oil is fantastic for relieving minor joint pain and calming muscle spasms. Looking for ways to increase testerone and balance hormones for my wife as well. This will help to keep your Vitamin D levels balanced. Regarding Vitamin D, there is another great way of increasing its levels. Too much zinc can diminish your body’s ability to absorb other minerals such as copper and can lead to nausea as a negative side effect. TC (total cholesterol); HDL-C (HDL-cholesterol); LDL-C (LDL-cholesterol); CRP (C-reactive protein). The Ethics Committee of the Sherbrooke Geriatric University Institute approved the study, and all subjects provided written informed consent before being enrolled. None of the female subjects was undergoing estrogen replacement therapy for menopause. The beneficial effects of polyphenols appear to be mediated via a plethora of biochemical pathways and signaling mechanisms that act either independently or synergistically. Interestingly, we recently showed that RCT is also impaired with aging, especially by changes to the ABCA1-mediated cholesterol efflux pathway 9, 10. Lowering your cortisol levels will make you feel more calm and relaxed and improve your anabolic hormones. Compared to steady state cardio, HIIT training burns more calories in less time and increases your muscular and cardiovascular endurance. In 2012, an article concluded that high-intensity interval training produces more free testosterone than steady-state cardio (13). Therefore, the intake of these flavonoids may delay age-related decline in testosterone production in males. Such discrepancy in the effects of catechins on testosterone levels needs further investigation to better define their regulatory mechanisms. Rutin (12) also partially reversed cadmium-induced decline in plasma testosterone levels in male rats by increasing Hsd3b and Hsd17b3 enzyme activity 74,75. Moreover, exposure to genistein (6) during perinatal development in male rodents resulted in reduced anogenital distance, lower testosterone serum levels, and decreased testicular mass compared to male rats under a normal diet 55,56,57. In addition, onion was found to decrease the formation of malondialdehyde, a marker of oxidative damage, particularly lipid peroxidation, in normal male rats and male rats with aluminum-induced reproductive toxicity . Specifically, luteinizing hormone regulates the expression of 17β-hydroxysteroid dehydrogenase, which catalyzes the conversion of androstenedione to testosterone. The function and the number of Leydig cells in the testis in turn is regulated primarily by luteinizing hormone and secondarily by follicle-stimulating hormone . However, more confirmatory human studies in this specific research context are still very imperative. Moreover, the monounsaturated fats in olive oil support hormonal balance, which plays a crucial role in sexual function. It is rich in antioxidants and healthy fats, which can improve blood circulation and enhance overall cardiovascular health. Olive oil, particularly extra virgin olive oil, is known for its numerous health benefits, including sexual health. Olive oil, with its rich profile of monounsaturated fats, antioxidants, and anti-inflammatory compounds, offers a range of benefits for sexual health. The Role of Healthy Fats in Testosterone Production: A Comprehensive Guide However, some other studies have failed to find significant effects of palm oil or coconut oil on body weight. Despite providing the same energy content, different oils have been reported to have varying effects on body weight. Edible oils consist of a combination of various types of fatty acids, and it can be difficult to identify the predominant fatty acid in a specific oil. Multicomponent interventions, interventions solely focused on fatty acids, and interventions involving mixed oils (combinations of two or more edible oils) were excluded. So, how does nut oil increase testosterone? There are many ways to use these oils to potentially boost testosterone levels and its effects (mood, skin, sex drive, etc.). Here are 5 essential oils that are beneficial for testosterone levels and their effects. Additionally, the presence of antioxidants in certain oils may modulate their health effects related to fatty acids. The SUN prospective cohort study, involving 7,368 Spanish university graduates, explored the association between olive oil consumption and the risk of weight gain and obesity, reporting that individuals adhering to an olive oil-rich Mediterranean dietary pattern did not have an increased risk of obesity . Pomegranates come with numerous advantages like lowering stress levels, lowering your blood pressure, and improving your mood.In the animal studies, considering the studies conducted on onion juice, the minimum used dose was approximately 0.5 mL rat−1 day−1 and the maximum used dose was approximately 6 mL rat−1 day−1.Understanding the contribution of adipokines in testicular functions is of special interest, and little is known about the effect of omega-3 and omega-6 supplementation on testicular adipokines, particularly their potential effects on spermatogenesis and steroidogenesis.A first study led by Coni and colleagues demonstrated that the dietary administration of 7 mg/kg of Olp increased the capacity of LDL to avoid oxidation and decreased the plasmatic amounts of total, free, and esterified cholesterol in twenty-four female New Zealand white rabbits .Although women make smaller amounts of it in their bodies, testosterone is the major male sex hormone.Human seminal plasma levels of vaspin are positively correlated with sperm DNA fragmentation and negatively correlated with ejaculate volume .The relationship between breast cancer risk and dose-response olive oil was not significant; the OR (95% CI) for breast cancer in the dose-response meta-analysis with a 14 g/day increase in olive oil intake was 0.93 (0.83–1.04) .Biosynthesized OLP aglycone (OLA) inhibited tamoxifen-resistant MCF-7 cell growth, whereas normal breast epithelial cells did not change.A broad spectrum of health-promoting properties of plant polyphenols comprises antioxidant, anti-inflammatory, anti-allergic, anti-atherogenic, anti-thrombotic, and anti-mutagenic effects.Darker honey varieties often have higher levels of flavonoids and polyphenols, which combat oxidative stress and promote better testosterone balance. The polyphenols in extra virgin olive oil protect cell membranes and reduce inflammation, creating a metabolic environment conducive to muscular well-being. Through its anti-inflammatory properties, olive oil can contribute to a more stable hormonal environment. T and LH serum concentrations significantly increased after the intervention period. We observed an EVOO-PC concentration-dependent increase in ABCA1 protein expression in J774 macrophages incubated with EVOO-PC (Figure 3(b)). The small upper panel shows the positive correlation between EVOO-PC concentrations and ABCA1-dependent cholesterol efflux. (a) 3H-Cholesterol-loaded J774 macrophages were incubated for 12 h with various concentrations of EVOO-PC (0 to 320 μg/mL) or with cAMP (positive control) to generate ABCA1-enriched cells, which were incubated with 25 μg/mL of apo-AI for 4 h. Drinking alcohol stimulates the transformation of testosterone into estrogen, which can further lower your bone density and libido.The mechanism by which this occurs is mainly by reducing the oxidative damage to Leydig cells; given that onion contains potent antioxidant molecules such as quercetin and quercetin glucosides, thiosulfinates, and anthocyanins .Sertoli cells appear with normal nuclei and the basement membranes enclosed by myoid cells (Figure 6a).Virgin olive oil (VOO) which has a free acidity, expressed as oleic acid, of not more than 2 g per 100 g and the other characteristics of which correspond to those fixed for this category in the IOC standard.Testosterone (T), luteinizing hormone (LH) and dehydroepiandrosterone (DHEAS) serum concentrations were measured at the beginning of the study and at the end of each period.Still in the context of atherosclerosis prevention, a randomized double-blinded, placebo-controlled crossover trial was carried out to determine the effect of two gastro-resistant capsules containing HT (15 mg/day for three weeks) in forty healthy volunteers (18–65 years old).The main findings of this review indicate that some herbs, particularly fenugreek seed extracts and ashwagandha extracts, have positive effects on testosterone concentrations in men.One of the most comprehensive, natural ways to increase testosterone is consuming coconuts or coconut oil.However, very few studies have been conducted on the effect of phenolic compounds on RCT.In fact, new research being conducted in Australia has clearly identified a ‘cause and effect’ relationship between our diet quality and our mental health (16). Testosterone Booster for Men Over 40: Addressing Age-Related Decline in T Levels One study also pooled the results of participants from different countries (Brazil, Ghana, US) . Supplementary Table 2 shows characteristics of the studies were included in analysis. Each edible oil intervention was represented by nodes, with node size proportionate to the sample size of the corresponding intervention . Our results showed that tyrosol and hydroxytyrosol increase in concentration-dependent manner the ABCA1-dependent cholesterol efflux (Figures 4(a) and 4(b), resp.). To investigate the mechanism by which EVOO-PC induces the increase in cholesterol efflux from J774 macrophages to apoA-1, we performed Western blot analyses to measure ABCA1 protein expression on J774 macrophages incubated with EVOO-PC. EVOO-PC increases ABCA1 protein expression and enhances apoA-I-mediated cholesterol efflux. The peroxidation by CuSO4 of the polyunsaturated fatty acids (PUFA) in HDL and LDL was assessed by the formation of conjugated dienes. Surprisingly, the type of protein ingested appeared to differentially impact serum testosterone levels. Refined carbohydrates (CHO; 1 L orange juice) had no significant impact on serum testosterone levels overall (Figure 1). Fasting produced minimal changes in serum testosterone levels over the observed 5 h period. Adjustments were made where appropriate for BMI, age, physical activity levels, sleep, total energy and fat for the habitual diet. Our study aimed to investigate in an inpatient setting the impact of various macronutrients of precise content on testicular endocrine function, while controlling for habitual diet and other factors like sleep and exercise levels. Only 6 out of 32 studies were assessed as having a low risk of bias due to their strong methodological study designs. This means that testosterone may have a greater physiological effect in the body when concentrations of these biomarkers are elevated. For example, in an animal study, Asian ginseng reduced the activity of 5α-reductase, the enzyme responsible for the conversion of testosterone into dihydrotestosterone (DHT) (80). In this review, Asian ginseng only had 1 study out of 7 demonstrating a positive effect on testosterone concentrations in men; however, its administration reduced cortisol concentrations in adults experiencing high work stress (78). Asian ginseng also has antioxidant properties, which reduce lipid peroxidation and increase glutathione peroxidase concentrations (74), and it is noteworthy that the only study demonstrating benefits of Asian ginseng recruited individuals with metabolic syndrome (47). A man produces testosterone in high amounts when they are young, somewhere in their 20s, and the production levels start dropping as they get older, about 30 years and above. Summary of the mechanism of action of flavonoids and isoflavonoids on testosterone production from testicular Leydig cells. This may explain the more potent inhibitory action of isoflavones on testosterone production from H295R adrenal cells, compared to a flavonoid such as apigenin (2) which has its phenol group in the position 2 of cycle C . Thus, anthocyanidins may promote testosterone production by Leydig cells through their antioxidant properties. Oleic acid increased the proliferation and migration of cervical cancer cells. OO polyphenols increased GSH levels, the most crucial intracellular antioxidant molecules measured by flow cytometry, but did not alter ROS levels. Bioactivities of OO were characterized by a high level of monounsaturated fatty acid and antioxidant effects of polyphenols. Overall, 9 out of 32 studies demonstrated significant increases in testosterone concentrations. One randomized, double-blind, placebo-controlled study was conducted examining the effects of cordyceps (manufactured by a submerged culture technique with the mycelia spray-dried to obtain a powder) on testosterone concentrations (44). One randomized, double-blind, placebo-controlled study was conducted examining the effects of a longjack extract (Physta®, manufactured by Biotropics; freeze-dried water extract) on testosterone concentrations (45). One randomized, double-blind, placebo-controlled, partial-crossover study was conducted examining the effects of a stinging nettle root extract (synthesized from the roots via a fractional percolation process and standardization) on testosterone concentrations (60). One randomized, double-blind, placebo-controlled study was conducted examining the effects of reishi extract (dried and chipped with 30% ethanol) on testosterone concentrations (55). A cross-sectional survey reported that testosterone levels declined 25% among adolescent and young adult men in the USA in 2015–2016 compared to sixteen years ago . Increasing intake of soybean oil could raise the serum LA and ALA levels and decrease serum PA levels. Also, the saponins in the argan oil decrease the absorption of cholesterol in the intestine and thus affect the testosterone level. The concentration of these compounds in EVOO is quite variable and depends on a series of factors including cultivar, the area of origin of the product, the fruit ripening stage, and production methods .This suggests that our findings are unlikely to be explained by confounding by indication, whereby men with intake of supplements have a healthier lifestyle and better health behavior, factors that may also affect their semen quality and reproductive hormones.I also dive into how to raise testosterone naturally, and why you shouldn’t go for HRT first.Nutrition is the foundation for healthy testosterone, but it has its limits.If necessary, missing data from relevant studies were obtained by contacting the corresponding authors.This may be attributed to the relatively low dose of chrysin (1) used in this research compared to studies with rodents. By prioritising nutrient-dense foods such as eggs, oysters, fatty fish, and healthy fats, you can naturally optimise your hormonal profile for better muscle-building outcomes. The monounsaturated fats in olive oil also promote heart health and improve nutrient absorption, both of which are beneficial for muscle growth. A study in “The Journal of Nutritional Biochemistry” found that ginger supplementation boosted testosterone levels by 17% in infertile men (Kadir et al., 2012). A deficiency in zinc has been directly linked to lower testosterone levels, making oysters a powerful food for muscle growth and hormonal health. Indeed, we have shown that luteolin (3) can increase Leydig cell steroidogenesis by upregulating StAR expression 24,25. Luteolin (3), a flavone, has been of growing interest in our laboratory for its potential in improving androgen production. As for chrysin (1), apigenin (2) was able to decrease the levels of DAX1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on the X chromosome, gene 1), an important repressor of StAR transcription . One question that’s frequently asked is whether or not bananas can lower your testosterone. They can also have very potent testosterone-boosting capabilities, according to researchers. Additional research reveals that DHA can improve men’s sperm quality and production (24). They’re great for maintaining and improving heart health (22), and a 2019 article reported their potential effectiveness in treating mood disorders (23). According to the National Institutes of Health (21), fortified foods provide most of the vitamin D in American diets. It affects a man’s appearance, muscle size and strength, sperm production, and sex drive. Testosterone is the hormone that gives men their male characteristics. Low testosterone can cause sexual dysfunction. This oil also contains powerful antioxidants that protect your heart and blood vessels from oxidative damage, promoting overall cardiovascular wellness. This effect is attributed to its ability to protect sperm cell membranes from oxidative damage, especially in cases of male infertility. Nonetheless, several complex issues, raised exactly by the in vivo studies, still remain unresolved and need to be further investigated to establish the ideal dose to be used in a defined physio-pathological context and the food matrix for maximum bioavailability and thus biological activity. Main mechanisms involved in the protective effects of EVOO phenolic compounds against cardiovascular and metabolic diseases. The modulation of plasma lipids profile and blood sugar level is the key factor in the beneficial effects observed in the prevention of metabolic illnesses, such as T2D. A specific health effect has been shown at the vascular level, where EVOO polyphenols show an efficacious anti-atherogenic action, through the maintenance of vascular function and blood pressure, and the inhibition of the endothelium adhesiveness (i.e., lowering adhesion molecules synthesis and exposure) and thrombogenicity. Furthermore, they are able to modulate the gene expression of several antioxidant enzymes, showing interesting insights and confirming what has been observed in nutrigenomic studies . According to medical experts, as we age, testosterone levels in a man’s body fall by 1 to 2% on average. High-stress levels increase cortisol, which consequently affects your free testosterone levels. Taking olive oil reduces the volume of harmful bad cholesterol levels in the blood vessels. This blog delves deep into finding out whether vegetable oils are good for testosterone production and what scientific studies suggest. The association of intake of fish oil supplements with lower FSH levels but not with a difference in inhibin B levels indicates a potential benefit of ω-3 fatty acid on spermatogenic capacity and testicular function. Therefore, we examined the association of intake of fish oil supplements, which are high in ω-3 fatty acid, with testicular function as measured by semen quality and reproductive hormone levels. Supplement intake of ω-3 polyunsaturated fatty acid has been found to improve semen quality among men with infertility, but the association with semen quality among healthy men is unknown. While age-related testosterone decline is a natural process, adopting healthy lifestyle habits can help maintain optimal testosterone levels. Make sure the beef is organic, because pesticides and insecticides can lower your testosterone. This is because fats reduce globulin, the hormone that binds to, and reduces T. Also, focus on exercises that work a large number of muscles at once to further increase the intensity. The way to do this is to increase the weight being lifted, and lower the number of reps. Push yourself harder, for a shorter period of time. One question that’s frequently asked is whether or not bananas can lower your testosterone.HT, the main phenolic compound of the olive oil, has also been shown to be effective in breast cancer.In this study, the administration of sunflower oil and omega-3 significantly inhibited NF-κB and downstream cytokine production.This study used a digital volume pulse to measure vascular function in a randomized, double-blind, placebo-controlled, crossover, acute intervention trial in humans .Alternatively, you can also take Omega-3 supplements to get your fatty acid fill.Evaluation of testosterone levels following a 3-month period of dietary modifications.Of course, on the other end of the spectrum, you have men with body fat that’s 30% ore more, which isn’t doing any good for your testosterone either.The process of extraction of olive oil depends on crushing olives and then separating the oil from the fruit pulp under elevated pressure.A study was done on the effect of 1 week of sleep restriction on testosterone levels in young healthy men (2).But there are always ways to lower the testosterone decrease and supplementation is one of them. Our results demonstrated that a high saturated fat diet is able to modulate testicular GGT activity. Previous studies have shown that GGT is present in epididymal epithelial cells and luminal fluids . High fat diets inhibit the gene and the protein expression of several RAS components in testis, including angiotensin converting enzyme (ACE), renin and AT1 receptor, and enalapril, an ACE inhibitor, reverts these changes . However, others recently reported that baicalein (4) administration for four weeks reduced serum testosterone and FSH and LH levels following treatments of a rat model for polycystic ovary syndrome (PCOS) . Interestingly, chrysin (1) seems to increase the sensitivity of Leydig cells to cAMP-dependent stimulation of StAR expression. Furthermore, luteolin (3) increased StAR transcription by inhibiting the expression of Dax-1 as reported for other flavonoids . Overall, apigenin (2) seems to increase steroidogenesis in Leydig cells mainly by increasing PKA-dependent StAR protein expression. However, others have shown that apigenin (2) inhibited the production of 5α-androstane-3α, 17β-diol (DIOL), the main androgen of rat immature Leydig cells . But as men reach the age of 30, testosterone levels can begin to drop, making it more difficult to look and feel your best. Give your testosterone an even greater boost by including a supplement routine that will keep you healthy, energized and in better shape than if you hadn’t bothered. One of the most powerful foods to increase testosterone is just the cherry on top of the huge list of health benefits that ginger provides. My dad has started to notice that his testosterone levels are dropping every year and he is noticing changes. Garlic supplementation increases testicular testosterone and decreases plasma corticosterone in rats fed a high protein diet. There were 1125 men (67.0%) who did not use any supplements, 210 men (12.5%) who used multivitamins, 98 men (5.8%) who used fish oil supplements (of whom 37 37.8% reported intake on fewer than 60 days and 53 54.1% reported intake on 60 or more days), 70 men (4.2%) who used vitamin D supplements, and 25 men (1.5%) who used vitamin C supplements. We subsequently compared men who used no supplements with men who used other supplements (including vitamin D, vitamin C, and multivitamins) because we expected supplement users to be healthier than men with no supplement use or fish oil supplement use. Starting in 2014, estradiol levels were assessed with a radioimmune assay (Pantex), and testosterone and sex hormone-binding globulin levels were assessed by chemiluminescent immunoassays (Access2; Beckman Coultier). Answers were categorized into no supplement intake, multivitamins, fish oil supplements, vitamin C supplements, vitamin D supplements, or other supplement intake. Weekly alcohol intake was calculated as the sum of the reported intake across all beverages.18 Men were also asked to rate their general health and physical fitness (ie, very good, good, average, poor, or very poor). Monounsaturated fatty acid (oleic acid) and polyphenol constituents (such as oleuropein, hydroxytyrosol, and tyrosol) were important components that explain the protective role of OO in these diseases 6,7,8. One of the most prominent parts of the Mediterranean diet (MD) is OO consumption, which is the principal source of fats. Their effects have been clarified in many suggested mechanisms and have shown promising results in animal and human studies, especially in breast cancer, ovarian cancer, postmenopausal osteoporosis, and other disorders. Are you looking to buy the best olive oil for your hair growth journey? Get ready to unlock the natural power of olive oil for your best hair yet! We will show you exactly what to look for in an olive oil to help your hair thrive. Be smart about your diet, and monitor the different types of fats that you’re eating. You probably think of testosterone as “the sex hormone.” But testosterone plays a number of vital roles in your body, from helping to maintain muscle and bone growth to boosting energy. Integrating this research into dietary guidelines would also allow healthcare professionals to provide evidence-based recommendations to patients, improving public health outcomes by encouraging the consumption of functional foods rich in beneficial bioactive compounds. Additionally, long-term studies will be necessary to assess the sustainability and potential cumulative effects of these compounds over extended periods, thus offering insights into their real-world applicability. In vivo studies have also highlighted the ability of EVOO polyphenols to regulate glucose and lipid metabolism and increase insulin sensitivity, through molecular mechanisms not yet clarified, but probably linked to the modulation of gene expression like those encoding lipoproteins and their major components. However, EUROLIVE’s shorter duration was still sufficient to detect changes in oxidative stress and HDL cholesterol, although it limits the understanding of longer-term effects. The authors of this research suggested that phenolic-enriched nutraceuticals, out of their original matrix, may exert adverse consequences instead of beneficial effects , acting by decreasing post-transcriptional apolipoprotein A-I expression and, with a consequent oxidative mechanism, increasing the concentration of oxidized low-density lipoproteins (ox-LDL). Furthermore, the intracellular signaling pathways and gene expression involved in the effects verified, if present, will be highlighted to link macroscopic in vivo effects to what occurs at the cellular level. Our goal is to provide a comprehensive estimation of the effects that are actually verifiable in vivo, especially in the context of cardiovascular and metabolic pathogenesis. This suggests that a higher intake of EVOO, similar to traditional MD, may be necessary for maximum cardiovascular benefits (Table 3). In the EUROLIVE study, a smaller daily dose of 25 mL of OO was administered, while in the OLIVAUS study the administered dose was 60 mL/day. OLIVAUS used a high-polyphenol EVOO and found additional benefits for inflammation and LDL reduction, emphasizing the broader health impact of high-polyphenol OO. However, the OLIVAUS study also demonstrated a reduction in LDL-C and inflammation, which are critical risk factors for CVD, providing a more comprehensive assessment of OO cardiovascular benefits. Taking into consideration the main macro-studies highlighted in this section, namely EUROLIVE and OLIVAUS, we find in some cases a complementarity of the results obtained, but there are also limitations and useful indications for future research. Besides, surprisingly, serum testosterone was found to be higher in Okinawan men compared, for examples, with the age-matched Americans . Yet, some of these phytochemicals are under basic and translational research to explore their possible biological effects in humans. At this moment in time, onions become part of humans’ food; for example, in 2016, the world production of onions (dried onions) reached more than 90 million tons, led by China (~26% of the total) and India (~21% of the total). Examples of this specific research intention included the use of certain types of food or dietary supplements. These effects were maintained after controlling confounders of age, BMI, physical activity, comorbidities, diabetes and prostate cancer . Dietary intake data were assessed from weighted food records from 5 weekdays and two weekend days using Foodworks 8 software (Xyris Software Australia Pty Ltd., Australia). As there was a significant difference in the baseline (fasting) measures across the feeding protocols for testosterone, oestradiol and follicle stimulating hormone (FSH), the data were normalised and presented as a measure of change from the fasting baseline. There were no significant differences in the demographic, lifestyle factors, energy or macronutrient intakes and baseline hormone status across the fasting or feeding protocols (Table 2 and Table 3). Unfortunately, the individual participants in each feeding protocol varied over the 18-month duration of the study due to participants gaining full time employment (and no longer being available), which made changes in participants necessary. Tyrosol and hydroxytyrosol increase ABCA1 protein expression and enhance apoA-I-mediated cholesterol efflux.A cross-sectional survey reported that testosterone levels declined 25% among adolescent and young adult men in the USA in 2015–2016 compared to sixteen years ago .Raw honey testosterone benefits include its ability to regulate blood sugar levels more effectively than refined sugars.Lean and toned up body isn’t just a far-fetched fantasy.Oleuropein induces apoptosis in breast cancer cells (MCF-7) via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Moreover, wide separation was observed between the neighboring cells and the vacuoles for most cells. Spermatogenic cysts were observed together with the separated and ruptured basement membranes of germinal epithelial cells and degenerated germ cells with pyknotic nuclei. The histological and ultrastructural examination conducted in this study showed that treating rats with paracetamol for 15 days caused distortion and toxicity in the testis compared to those of the controls. Protective effect of EVOO against paracetamol toxicity in blood and testis in male Wistar rats. The administration of omega-3 or omega-6 resulted in decreased serum concentrations of kisspeptin 1, gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone, and testosterone. Qi X et al. suggested ALA could increase the testosterone secretion, which may be related to higher StAR and CYP11A1 mRNA expression and SF-1 expression . We believe that it is at least part of the LH of high levels acts on up-regulated LHCGR that activate the process of testosterone synthesis. A cross-sectional study indicated that a positive association was observed between the intake of PUFAs, particularly of ω-6 PUFAs, and LH concentrations . Compared with ND group, the serum ALA of SOY group was significantly increased. Extra virgin olive oil’s modulation of nuclear factor κB (NF-κB), a transcription factor regulating gene transcription in cytokines, chemokines, adhesion molecules, inflammatory proteins and COX-2 (and several others), plays a significant role. In studies specifically focused on MS patients, EVOO significantly reduced C-reactive protein (CRP) values, IL-6, IL-7, and IL-18 plasma levels (49), and pro-inflammatory molecule gene expression (50). In addition, an increase of anti-inflammatory cytokine IL-10 levels (43) and inhibition of some cell adhesion molecules (VCAM-1 and ICAM-1) have been reported (47). Oysters aren’t the only shellfish that can make a positive difference in our hormone levels. Plus, no other food beats an oyster when it comes to containing zinc, one of testosterone’s most important allies. And that’s why it’s so important you do everything you can to ensure your testosterone continues performing as efficiently as possible. Conducting larger human clinical trials would not only provide more robust data but also help address existing variability in smaller studies, ensuring more reliable conclusions. Bioavailability, however, must be referred to the whole complex mixture of parent compounds and metabolites originated by in vivo metabolic activity and biotransformation, which are important contributors to the discrepancies between in vitro and in vivo studies and observed in vivo interindividual variability in the biological effectiveness of EVOO phenolic compounds. A large body of knowledge has provided evidence of the benefits of the Mediterranean diet and olive oil consumption on the prevention of atherosclerosis and CHD 24–27. In the present study, we investigated the atheroprotective effect of the phenolic compounds in EVOO on cholesterol efflux and on oxidative stress damage in healthy subjects. Polyphenol-rich vegetable oils and monounsaturated fatty acids provide protection against an array of human diseases such as cancer, atherosclerosis, and CVD, including those involving the central nervous system. For example, research has shown that a diet rich in olive oil can improve heart health, which is closely linked to sexual function. As this is the first study to show that egg white protein increased testosterone levels over a 5 h period, further larger chronic studies replicating these findings need to be conducted before dietary recommendations can be made. Extra virgin olive oil is a healthy fat that has been shown to improve testosterone levels. This study also substituted Argan oil for olive oil, and the testosterone levels increased by about 20%. One study found that Moroccan men who added olive oil to their diets saw an increase in testosterone levels by 17%. A good example of this is a human study by Volek et al.1, which found out that total fat intake, SFA, and MUFA raised serum test levels, but when the ratio of PUFA to SFA was increased, testosterone production took a nosedive. Processing foods may enhance their taste or give them a longer shelf life, but it can come at a great cost to your body. Among the biggest testosterone-killing foods are those that have been processed, meaning they’ve been canned, cooked, frozen, packaged, or had their nutritional content altered or removed. Not only do both bulbous vegetables add complexity to easy-to-make meals, but research suggests they can also help give your T levels a boost, as well. The combination of raw honey with nutrient-dense foods amplifies its natural benefits for testosterone health. Yes, pairing raw honey with testosterone-supporting foods can enhance its effects. Incorporating the best honey for testosterone into your diet can be both simple and delicious. Specifically, epicatechin (18), which is a catechin (17) epimer, increased the activity of Hsd17b3. Hesperidin (16), a glycosylated form of hesperetin, (Figure 7) was also reported to reverse the decline of testosterone production in diabetic rats . Overall, flavonols such as quercetin (7) are promising in increasing steroidogenic enzymes activities and may prevent age-related decline in testosterone production in men. Taxifolin (13) has been shown to inhibit androgen production in immature rat Leydig cells by inhibiting the activities of Hsd3b and Cyp17a1 enzymes . Testosterone levels tend to increase at the onset of sleep and peak during REM (rapid eye movement). Studies show that over time, too much of the stress hormone blocks other bodily functions (44) that aren’t considered “fight-or-flight” worthy, including testosterone production. If your levels are clinically low, you may want to consider the option of testosterone replacement therapy. Check out our list of testosterone-killing foods to see what to cut out of your diet. This decline in testosterone is for numerous reasons, including lack of exercise, a bad diet, stress, and environmental endocrine disruptors. Today, low testosterone is on the rise, and it’s even more common to see it in young males. Studies suggest the mineral may increase T levels, but that's not the only reason to consider getting more Z. Learn what it takes to boost energy, maintain strength, and stay healthy longer—delivered to your inbox every Monday. Moderate exercise can elevate testosterone and semen levels (49), as well as improve brain function, self-esteem, and mood (50). Most likely, HT increases mitochondrial biosynthesis pathway via upregulation of PGC-1α. The studies on the 3T3-L1 adipocyte cell line have shown that HT stimulates mitochondrial biosynthesis which is reduced in the course of diabetes mellitus. Free radical scavenging properties of HT have been convincingly confirmed in studies on rats with alloxan-induced diabetes mellitus . In clinical studies including patients with first-degree hypertension treated with olive leaf extract, the tendency to lowering the blood pressure was observed. A refining process is meant to purify the extracted oil from any residual solvent and other impurities. Basic concept: what to know before performing sample size calculation and power analysis While not food per se, extra-virgin olive oil is one of the best testosterone boosters for men who are suffering from hormonal issues. Cortisol is a stress hormone known to lower T levels, so eating a fish diet twice or thrice a week can help keep testosterone-related problems at bay. Fatty fish contains Omega-3 fatty acids and Vitamin D, which are beneficial when it comes to boosting testosterone. Aside from the slew of nutrient-rich properties these vegetables contain such as Vitamin D, there’s one mineral that trumps all the others in terms of maintaining optimal testosterone levels. Pomegranates are rich in antioxidants, which help reduce oxidative stress and inflammation—two factors that can suppress testosterone production.The olive oil obtained from this kind of process is usually characterized by stronger color intensity, weaker aroma, and a higher content of free fatty acids 12,13,14.In addition, thyroid hormones and thyroid status have varied effects on the pharmacokinetics and actions of other drugs.The risk of developing DM decreased by 13% with EVOO intake of 15–20 g/day, but no advantages from further dose increases were proven.Participants completed the Pittsburgh Sleep Quality Index questionnaire to determine their sleep quality, while average physical activity levels were quantified using the Baecke Physical Activity Questionnaire .The more successful you are, and the more confident you are, the more testosterone you’ll produce.An acetylated form of quercetin (7), pentaacetylquercetin (9), successfully increased cAMP-dependent accumulation of progesterone from MA-10 Leydig cells, possibly through the activation of StAR and Cyp11a1 transcriptions .The exertion of your muscles to push or pull weights releases a flood of anabolic hormones into your bloodstream, including testosterone. Since cortisol, the body's major stress hormone, is inversely correlated with testosterone concentrations (85), reducing its production may elevate testosterone concentrations. Moreover, the testosterone-enhancing effects identified in the single study on forskohlii (40) are consistent with the results of an animal study where reproductive toxicity in rats, induced by the pro-oxidant mancozeb, was attenuated by forskohlii supplementation, potentially resulting from its antioxidant properties (84). Asian ginseng also had 1 study demonstrating its efficacy in increasing testosterone (extract details not provided), but there were 6 studies demonstrating no effect. Fenugreek seed extracts (positive findings in 4 out of 6 studies) and ashwagandha root and root/leaf extracts (positive findings in 3 out of 4 studies) demonstrated the most consistent increases in testosterone concentrations. Potential Health Benefits of Olive Oil and Plant Polyphenols Here, we will explore some tips for maintaining a healthy amount of testosterone to help support our bodies’ natural functions. Testosterone helps to maintain many bodily functions such as proper red blood cell levels, regular sleep patterns, healthy libido, a healthy pain response, optimal bone density, muscle mass, and high energy levels. Collectively, there is an evidence that onion or onion extracts (e.g., aqueous extract ~30 mg day−1) enhances testosterone production in males. Provided you don’t have any pre-existing cholesterol issues, there’s no reason why you can’t enjoy an egg or two each day. Egg yolks offer the majority of nutrients found in an egg, including proteins and carotenoids like lutein and zeaxanthin, which can promote vision and cognitive health. That philosophy has changed over the past 20 years, however, and egg yolks have earned a spot among the healthiest existing food choices. Similarly, there are also foods we eat that can lower our testosterone levels and overall health. Moreover, adult male albino rats with atrazine-induced reproductive toxicity administered quercetin at 10 mg−1 kg−1 of body weight for 21 days had higher levels of testosterone compared with the control . Such enhancement for the antioxidant defense mechanism in Leydig cells by the effect of onion may increase the production of testosterone. In particular, increased generation of reactive oxygen species, and hence the oxidative damage in testicular Leydig cells may reduce the synthesis of testosterone . In addition, aqueous onion extract (1 mL of the extract/100 g of body weight, for eight weeks) significantly increased luteinizing hormone in both normal and aluminum chloride-treated male rats . One randomized, double-blind, placebo-controlled study was conducted examining the effects of a forskohlii root extract, manufactured to contain a forskolin concentration of 10% (Forslean) daily (extraction process not provided) on testosterone concentrations (40). One randomized, double-blind, placebo-controlled study was conducted examining the effects of a garcinia extract (standardized to contain 60% hydroxycitric acid; details of extraction process not provided) on testosterone concentrations (43). One randomized, double-blind, placebo-controlled study was conducted examining the effects of a musali root extract (water extract of dried root tubers) on testosterone concentrations (59). One randomized, double-blind, placebo-controlled study was conducted examining the effects of a rhodiola extract (standardized to 3% rosavins) on testosterone concentrations (46). Three randomized, double-blind, placebo-controlled studies (41, 52, 66) examined the effects of maca on testosterone concentrations. Some studies have suggested that food nutrients and diet may play pivotal roles in the regulation of RCT 25, 40–42. ABCA1 facilitates cholesterol efflux from cells to lipid-poor apo-AI but not to HDL 7, 37, whereas another ABC transporter, ABCG1, as well as the SR-BI receptor, is involved in cholesterol efflux from macrophages to HDL 38, 39. Plasma HDL-cholesterol levels are markedly and inversely correlated to the risk of atherosclerotic cardiovascular diseases . Interestingly, a study by Covas et al. showed that consuming EVOO increases the postprandial concentration of phenolic compounds in the plasma and in LDL and HDL, which may explain the protective effect of phenolic compounds. Tyrosol and hydroxytyrosol increase ABCA1 protein expression and enhance apoA-I-mediated cholesterol efflux. In addition, others have shown that chrysin (1) is a potent inhibitor of the enzyme aromatase, which converts testosterone into estradiol . Chrysin (1), 5,7-dihydroxyflavone, is present in high levels in honey, propolis, chamomile, mushrooms, fruit bark, and many plant extracts. We also reported that luteolin (3) was able to activate Fdx1 (Ferredoxin 1) transcription in MA-10 Leydig cells . Organic foods, which accounted for approximately 80% of the participants' diet, have been found to enhance the antioxidant capacity of the Mediterranean diet. Recommendations have been made to conduct such studies to provide solid evidence on the benefits of organic food (Glibowski, 2020; Hurtado-Barroso et al., 2017b; Vigar et al., 2019b). Adhering to a diet rich in antioxidants can help improve semen quality and counteract the negative impact of contaminants, including dangerous pesticides and phthalates (Montano et al., 2021; Kelly, 2004). Folate (vitamin B9) and vitamin B12, concentrated in the sperm head, provide essential nutrients for sperm production and survival (Azizollahi et al., 2013). The Mediterranean diet, which is rich in antioxidants and essential vitamins for sperm function, such as coenzyme Q-10, plays a crucial role in sperm motility by facilitating movement and energy release in sperm.