Ginger is a multipurpose herb and also has anti-inflammatory effects with hormonal health-supporting advantages. It also reduces cortisol, which is the stress-related hormone that reduces testosterone. However, conclusions are moderated by the paucity of research for many herbs, the variation in dosages and extracts used, small sample sizes, and the heterogeneity of study characteristics. Examining the safety and efficacy of an herb in different populations, such as healthy, aging men; men with comorbid medical conditions such as metabolic syndrome, obesity, or diabetes; men engaging in regular exercise; and in men taking concurrent medications, will also help to determine the most suitable groups to target for its use. Moreover, how quickly herbs influence testosterone concentrations in men needs to be elucidated. However, epidemiological studies have suggested that supranutritional Se intake and high plasma Se levels are not necessarily preventive against cancer, and may even be a possible risk factor for developing T2DM . Se was shown to have strong anti-proliferative and pro-apoptotic effects on human PCa cells and to improve severe metabolic side effects in patients 144,83. Thus, there is currently no clinical evidence for the proposed improvement of ADT-induced side effects by phytoestrogens, although limitations of these studies including small cohort sizes and short treatment durations should be taken into account. However, the erectile activity of the pomegranate-treated group did not normalize to the level of age-matched animals without arteriosclerosis. Moreover, they detected an accumulation of oxidatively modified byproducts and an upregulation in levels of superoxide-dismutase and aldolase reductase, both of which are known to be oxidation-sensitive genes. Analogous to the situation in patients with atherosclerosis, they found a decreased erectile tissue blood flow, diminished intracavernosal perfusion pressures, and impaired metabolic waste clearance from the erectile tissues. Among the proteins that were downregulated after treatment with pomegranate was valosin containing protein (VCP (p97)). These men are mainly responsible for the increase in testosterone-replacement therapies over the last decade . With aging, testosterone production declines, beginning in the 30s in men, at a rate of 1% per year . In addition, testosterone is indirectly involved in the development of the genital tubercle to form the penis, scrotum, and prostate by its conversion to 5 α-dihydrotestosterone (DHT), the most potent androgen of the body. With the cumulation of information on the actions of different flavonoids and isoflavonoids on steroidogenesis in Leydig cells, we can now draw conclusions regarding the structure-activity relationship on androgen production. But some research suggests that ginger extract may also boost your testosterone levels. Most recently, in a 2015 study, subjects that received 300 mg Ashwagandha extract twice a day for 8 weeks showed a testosterone increase of 3,3 nmol/l or % compared to the placebo group. If you're curious about its effects try incorporating pomegranate juice for a few weeks and pay attention to how you feel. Choosing whether to add pomegranate juice to your routine comes down to your personal goals and how your body responds. Science says pomegranate juice sometimes helps boost testosterone—for a short time. Dietary Supplements The study cohort of 104 patients was stratified according to their baseline PSA doubling time (PSADT) and Gleason score. The extract is well characterized, product specifications have been established, and batch analyses data confirm that the product is consistent in quality and free of microbial or chemical contaminants. The authors concluded from their study that antioxidative therapy appears to act promptly on molecular and ultrastructural alterations rather than on anatomical structures like erectile tissue fibrosis. Antioxidants, then, can have dozens of beneficial health outcomes. Eventually, like a bike chain, our cells simply break down and stop working. All of our cells are complicated, moving pieces of material that, when exposed to too much oxygen, begin to erode and rust up. With all the popularity, I wasn’t too surprised to see that one of our best-rated testosterone boosters had Pomegranate in its ingredients. I am an experienced publisher and seasoned healthcare enthusiast with numerous health websites under my belt. Preclinical and clinical studies provide evidence of their antiproliferative properties and modulatory effects on inflammatory pathways . Herein, we critically review the scientific knowledge about the current role and future prospects for the use of pomegranate extracts in the therapy of erectile dysfunction, benign prostatic hyperplasia, and prostate cancer. After 56 days of supplementation, hand grip strength and the circumference of the upper arm significantly increased as well.19 Raising testosterone in younger men is more challenging, because their levels have not yet dropped as much. To evaluate pomegranate and cacao extracts in humans, researchers gave men aged 36 to 55 either a blend of these extracts or a placebo. Cycling and Mental Health: Keeping the Connection Positive This amount has been linked to a significant increase in salivary testosterone levels—up to 24%. If you're looking to boost testosterone, consuming around 300 ml (about 10 ounces) of pomegranate juice daily can be beneficial. Studies show this amount can significantly increase your salivary testosterone levels, benefiting both men and women after just two weeks of regular intake. Incorporating pomegranate juice into your daily routine can be like planting a seed of vitality in your body. If you're on a quest for the ultimate testosterone-boosting juice, look no further than pomegranate juice! It may help a little by boosting nitric oxide and blood flow, but juice is high in natural sugar, so moderation is important. It may help improve erections in some men by supporting blood flow and nitric oxide levels, but it’s not a guaranteed or standalone treatment. Its antioxidants support blood flow, which may help your sexual health over time. Pomegranate is not a treatment for erectile dysfunction, but it can be a healthy addition to your diet. “LN18178 is a well-tolerated, safe, and effective nutraceutical blend that boosts sexual function, testosterone level, and psychological and general well-being in aging males.” Another study showed that pomegranate extract tablet (1000 mg containing 600 mg of polyphenol) for four weeks before radical prostatectomy could not lessen 8-hydroxy-20-deoxyguanosine (8-OHdG) levels, an oxidative stress biomarker, in 70 men . In one quasi-experimental study on 55 diabetic patients, consumption of concentrated pomegranate juice (CPJ) (45 g/day for 3 month) showed no statistically significant effect on FBG . Steer clear of most store-bought pomegranate juice, which tends to be filled with sugar—and sugar can actually make your sexual health worse. Pomegranate juice and pomegranate supplements are a popular way to get a shot of healthy goodness. “Apoptosis” is your body’s natural process where unhealthy cells self-destruct before spreading their “disease” to other cells. Pomegranate for Women’s Hormonal Health Since cortisol, the body's major stress hormone, is inversely correlated with testosterone concentrations (85), reducing its production may elevate testosterone concentrations. Another potential mechanism through which herbs may increase testosterone concentrations in males is by ameliorating cortisol production. Fenugreek seed extracts (positive findings in 4 out of 6 studies) and ashwagandha root and root/leaf extracts (positive findings in 3 out of 4 studies) demonstrated the most consistent increases in testosterone concentrations. One randomized, double-blind, placebo-controlled study was conducted examining the effects of a longjack extract (Physta®, manufactured by Biotropics; freeze-dried water extract) on testosterone concentrations (45). One randomized, double-blind, placebo-controlled, partial-crossover study was conducted examining the effects of a stinging nettle root extract (synthesized from the roots via a fractional percolation process and standardization) on testosterone concentrations (60). These ten foods can bring hormonal balance as well as enhance mood, metabolism, strength, and sexual health. The first step in increasing your testosterone is through food. Bananas are also right as a pre-workout meal both to support hormones and maintain stamina. Bromelain has a direct effect on testosterone and may boost sexual desire. It’s true that a 2020 study (12) reported a “Western” diet consisting of fried foods, processed snacks, high fat, and red meat could cause adverse effects on men’s T levels and sperm count. Vitamin K can promote bone health, protect against osteoporosis (9) and keep body inflammation down, which helps keep your T levels up. One published study observed how a group of 75 infertile men, after taking a ginger supplement for three months, experienced a 17 percent increase in their T levels (6). Researchers have proven that zinc can also help boost testosterone levels (1) as well as improve sperm quality and fertility (2). But there are also natural testosterone boosters, and a diet filled with the necessary nutrients that feed our testosterone can also help keep your testosterone levels high. It protects against gingivitis through direct antioxidant activity of flavonoid content and indirect effects via increasing free radical scavengers . Pomegranate extract acts as an anti-inflammatory compound and free radical scavenger capable of reducing macrophage oxidative stress and lipid peroxidation. After 30 days, the levels of glucose, insulin, LDL-C, TC, IL-6, MDA, and hs-CRP were decreased . There was a significant reduction in TBARS related to cardiovascular disease risk, and no serious adverse effects were observed . The heterogeneous results from these studies might also be due to variations in measuring FA consumption of individuals and different techniques assessing their diet 186,187,188,189,190. It is likely that differences in dosage, study population characteristics, the source of ω-3 FA, study duration, and background diet may explain the inconsistencies in these findings. On the other hand, encouraging results were obtained from clinical trials showing potential anti-inflammatory effects of ω-3 FA 77,174,175,176,177. In addition to this, at the range of doses studied, PFE lowered COX-II, iNOS, Ki-67 expression, and increased apoptotic index. The pomegranate, in large quantities, can lead to digestive problems, particularly to consumers with sensitive stomach or with certain drugs such as blood thinners. Pomegranate seems to increase testosterone by the means of their antioxidants and polyphenols; however, the effect is going to be incremental at best. Therefore, pomegranate can be used to manage the hormones of men and women. The experimental rats were further subdivided into 5 sub-groups based on varying doses of the crude methanolic bark extract of P. africanus (0 mg, 25 mg, 50 mg, 125 mg, and 200 mg). After forty-five days of treatment with the extract the animals were sacrificed blood collected through cardiac puncture for biochemical analysis. Material BPH was made in rats with daily administration of testosterone propionate (3 mg/kg) for 14 days. After 45 days, the rats were anaesthetised by a brief exposure to trichloromethane vapour and 5 ml of blood was collected from the rats through cardiac puncture and dispensed into well-labelled EDTA containers to avoid coagulation. In order to evaluate the beneficial effect of PJ and MEPP on lipid peroxidation and nitric oxide levels in testicular of rats. Those sweet-tart pomegranate arils can help keep your body healthy and disease-free. Studies have shown that garlic can naturally boost testosterone levels.3 Diallyl disulfide is the chemical in garlic that helps in the production of testosterone in the testes. This heart-healthy fish full of protein has been linked to testosterone production. These are all important factors that can help increase your testosterone levels. Before you try to boost your low testosterone levels with testosterone therapy, there are certain foods that can help naturally increase your levels. Nisshin OilliO America Unveils Foodservice Tech Lab, a Solution-Driven B2B Hub to Tackle US Kitchen Challenges Laboratory studies indicate that pomegranate extracts can slow down the reproduction of cancer cells and even induce apoptosis (a kind of programmed cell death). Regular consumption of pomegranate juice has been linked to improved blood flow, reduced arterial plaque, and decreased levels of LDL (the “bad” cholesterol). Of course, everyone’s body is different, and while some might see a significant increase in testosterone levels, others might not notice much of a difference. If you’re looking for “how much pomegranate juice per day for testosterone”, studies suggest to drink up to 500 ml twice a day for better outcomes. These certified clinical trials have outlined the role of pomegranate and pomegranate juice on testosterone and men’s health. Natural ingredients mean rare side effects when used correctly, but monitor for mild reactions. Hormonal balance isn’t just about the body; it’s about the brain. Testosterone plays a critical role in body composition. By improving blood flow and hormonal balance, Testo Dark helps eliminate “performance anxiety” and ensures you are ready when the moment is right. While specific clinical trials on Testo Dark are limited, component studies show promise for vitality support. The results revealed that both MEPP and PJ have potent antioxidant activity by reducing lipid peroxidation and nitric oxide formation in testis tissues of rats. The treatment with PFE at doses of 25 mg/kg, 50 mg/kg, and 100 mg/kg resulted in significant decreases in prostate weight by 28.4%, 35.1%, and 30.8% respectively compared to untreated BPH rats. For four weeks, the rats received their doses daily and orally via gavage. Get support These constituents of pomegranate juice are thought to provide many beneficial effects against organ damages. Among rats given daily pomegranate juice supplements alone, there were no marked changes in testicular histology relative to controls (Figure 6C). Effect of P. granatum juice on serum testosterone, luteinizing hormone and follicle stimulating hormone in rats treated with CCl4. Maintaining the optimal level of testosterone in the male body is essential. Among all fruits that we reviewed in this article, the one that increases test levels the most is pomegranate. You might still have more questions about testosterone-boosting foods and raising your testosterone levels. Although potential confounders were considered and adjusted for in our study, there are still some potential factors that may influence the relationship between diet and total T levels, including adipokines, and genetic and socioeconomic factors. It is likely that RBC functions (aggregation and deformability) may affect T levels through their ability to change shape and flow in microvessels while transporting oxygen and nutrients to Leydig’s cells of the testes. In this study, we also observed a positive relationship between RBC aggregation and insulin levels. As one of the best foods to boost testosterone, one 2012 study followed 60 men and women who drank pure pomegranate juice for 14 days. To study the protective effects of pomegranate on carbon tetrachloride mediated reproductive toxicity, twenty eight adult male rats were randomly allocated to four groups of seven rats of each. Pomegranate juice consumption increases significantly sperm quality, spermatogenic cell density, antioxidant activity and testosterone level in male rats . Twenty eight Wistar albino male rats were divided equally into 4 groups for the assessment of protective potential of pomegranate juice. I think it’s important to have realistic expectations, since results can vary based on health and daily habits.” People who are allergic to any of the ingredients in the formula may have a higher chance of experiencing side effects. Since there are no user reviews for Eros Lift yet, there is limited information about possible side effects. It is also a good idea to speak with a doctor before starting the supplement, especially if you have any health conditions. A study from 1996 measured the association between zinc and testosterone and found that restricting zinc intake from foods lowered testosterone levels in healthy men. However, a study from 2012 in infertile humans found that ginger was able to increase testosterone levels by 17 % and increase levels of other key sex hormones too. And finally, a study from 2011 found that Ashwagandha increased testosterone by 13 % in healthy men, by 10 % in smokers, and by 22 % in subjects experiencing a lot of stress! Drinking pomegranate juice does more than just support your testosterone levels. One study had 60 healthy men drink pomegranate juice every day for two weeks. Like oysters, shellfish like crabs and lobsters are high in zinc which as we have seen is one mineral that helps support the production of testosterone (30). Severe cases of zinc deficiency can lead to hypogonadism, a condition in which their body does not produce enough testosterone (17) which can then further lead to impotence or delayed sexual maturation in younger boys. Some research has shown that it can also help with weight loss, osteoarthritis, lowering blood sugar, improving heart disease risk factors, reducing menstrual pain, lower cholesterol levels and more. In addition, their high antioxidant content supports cardiovascular health, which is essential for good blood circulation and, therefore, for erectile function. In addition, its beta-carotene content, similar to that of figs, stimulates the production of sex hormones. Mango is known for its high content of vitamins A and C, which promote testosterone production. Lean meats, fish, chicken or turkey breast, and eggs are key nutrients for optimizing testosterone and promoting muscle building. This fruit has a high content of vitamin C and antioxidants that help protect cells. Like lemon, lime is rich in vitamin C and has antioxidant properties that help balance hormones. In addition, it keeps the immune system strong, and this is essential for overall sexual health. To consume it, prefer organic and cold-pressed juice. Interestingly, chrysin (1) seems to increase the sensitivity of Leydig cells to cAMP-dependent stimulation of StAR expression. Chrysin (1), 5,7-dihydroxyflavone, is present in high levels in honey, propolis, chamomile, mushrooms, fruit bark, and many plant extracts. Furthermore, luteolin (3) increased StAR transcription by inhibiting the expression of Dax-1 as reported for other flavonoids . The beneficial effects of pomegranate mouthwash or gel on periodontitis, gingivitis, and stomatitis are likely related to its anti-inflammatory, antioxidant, and antimicrobial activities. As suggested by one study, pomegranate also exerts a modulating effect on liver enzymes in diabetic patients. The major pharmacological effects of pomegranate reported in randomized clinical trials pertain to diabetes, cardiovascular disease, oral cavity disorders, endocrine disorders, and cancer. Asiatica and P. granatum extracts suggested a significant improvement in clinical parameters of chronic periodontitis and IL-1 levels compared to standard supportive periodontal therapy . Reduction of systolic, diastolic, and mean arterial blood pressure was reported in an RCT in which healthy subjects consumed 330 ml/day of PJ for four weeks . In a study by Aviram and Dornfield, PJ consumption (50 ml for 2 weeks) in 10 hypertensive patients reduced serum angiotensin-converting enzyme (ACE) levels (by 36%) and SBP (by 5%) which were attributed to antioxidative activity of pomegranate . Another study showed that pomegranate capsule (900 mg) reduced lipopolysaccharide-binding protein (LBP) levels, a marker of endotoxemia, in 57 patients with colorectal cancer . In studies by Nuñez-Sánchez et al., ellagic acid and urolithin derivatives were found in colorectal cancer tissues following consumption of pomegranate extract (900 mg for 15 days) . Several in vitro and in vivo studies demonstrated the anticancer properties of pomegranate which inhibits the proliferation of tumor cells and induces their apoptosis. Whole blood samples were collected from healthy volunteers in citrated tubes.Punica granatum and its components have multiple pharmacological effects and clinical applications.In fact, a surprising amount of everyday foods can significantly boost male hormone levels.Many studies have reported the anti-inflammatory potential of pomegranate extract.This enzyme is genuinely beneficial in increasing low test levels.The purpose of this study was to determine the causal physiological association between hormonal, metabolic and mechanical responses, and CF workouts performance after acute BJ intake.The most relevant functions include an increase in blood flow into the muscle, reduced oxygen uptake (VO2) at a given work rate , and blood vessel dilation through mediation by guanylate cyclase , among others.However, a high dosage of bromelain can cause side effects like diarrhea, nausea, and heavy menstrual bleeding. Leafy greens are also rich in magnesium, a mineral that has been linked to increased levels of testosterone. Because oysters have such high levels of the mineral zinc, they make up some of the best foods to boost testosterone production in the body, if your low testosterone is caused by a zinc deficiency (4). Age is one of the main causes of lower testosterone levels in men seeing as this hormone level naturally drops by 1 to 2 percent per year. The results clearly demonstrated that pomegranate juice augments the antioxidant defense mechanism against carbon tetrachloride-induced reproductive toxicity and provides evidence that it may have a therapeutic role in free radical mediated diseases.Despite the exact duration of the trial not being reported, nor were differences in the PSA concentrations among participating groups.Since CP targets rapidly dividing cells, it is extensively used to suppress tumor malignancy, and as an immunosuppressant for organ transplantation patients.To our knowledge, no more studies have investigated the effects of BJ intake on performance of specific WOD , therefore, no accurate conclusions can be drawn about the possible ergogenic effect of BJ intake on CF performance.Based on the above data, the antioxidant features of pomegranate juice extract contribute to its robust protective effects against coronary heart disease.Overall, flavonols such as quercetin (7) are promising in increasing steroidogenic enzymes activities and may prevent age-related decline in testosterone production in men.After forty-five days of treatment with the extract the animals were sacrificed blood collected through cardiac puncture for biochemical analysis. Almonds and walnuts, for example, increase sex hormone-binding globulin (SHBG), lowering test production. Contrary to popular belief that nuts can elevate test levels in the body, some nuts may cause low testosterone. These nutrients in T-boosting fruits are essential in increasing low test levels to help you maintain healthy test levels. The bromelain and B vitamins contained in bananas are especially important to keep your testosterone levels optimized. Eating a balanced diet focused on fresh foods and doing regular exercise may help you to boost your testosterone levels naturally. Luckily, there are a few foods that may help you increase your testosterone production. Obesity, fatigue, and depression are other symptoms of low testosterone levels. Be sure to first speak to your doctor and explore your options if you suspect that you have low testosterone levels. Although the proportions of IL-10+ Tregs and TGF-β+ Tregs were very low, both in control and PoPEx-treated cultures, there was a statistically significant relative increase of IL-10+ Tregs at higher concentrations of PoPEx in total T-cells (CD3+) and both CD4+ and CD8+ T-cell subsets. The level of IL-10, a key Treg cytokine, was increased at lower concentrations of PoPEx (12.5 µg/mL) and significantly decreased at 50–200 µg/mL of PoPEx. The proapoptotic concentrations of PoPEx (100 µg/mL and 200 µg/mL) induced oxidative stress in PBMC culture after 24 has detected by increased DCFDA fluorescence (Figure 4A,B). Imagine this ruby-red elixir flooding your body with powerful antioxidants, igniting your energy levels and enhancing your mood. Foods rich in zinc, like oysters, and those high in healthy fats, such as avocados and nuts, can be beneficial. Additionally, the natural antioxidants found in pomegranate can support heart health, making it a valuable addition to any diet. Cao et al., 2019, also showed that punicalagin at concentrations of 100 µM to 400 µM decreased the viability of RAW264.7 macrophages and inhibited their autophagy at lower concentrations (25 µM and 50 µM) after stimulation with LPS by inhibiting the FoxO3a autophagy signaling pathway . However, we extended our study to the expression of different autophagy-related genes. Our results demonstrated that pro-oxidative and proapoptotic concentrations of PoPEx are accompanied by decreased autophagy, as revealed by decreased AO fluorescence. We showed that lower, non-cytotoxic concentrations of PoPEx, induced expression of most genes involved in the antioxidative activity. In contrast, the antioxidant activity of pomegranate and its polyphenols has been shown both in vitro and in vivo. You can find bottles in the grocery store, but some bodybuilders like to squeeze their own for a fresh boost. The juice is bright red and tastes sweet and a little tart. Before you add that bottle to your cart you want real answers—because when it comes to your health you don’t want to fall for hype. As you consider dietary changes to boost testosterone, remember that a holistic approach—including exercise, proper nutrition, and lifestyle choices—will yield the best results. Adding pomegranates to your diet is easy and can be delicious. A controlled cross-sectional repeated measure study was observed by the Society for Endocrinology among 60 volunteers. Influencing naturally occurring antioxidants within the body like catalase, glutathione, and glutathione-peroxidase also helps in reducing testicular tissue damage. Pomegranate induces components that promote its antioxidant properties to support a man’s reproductive health naturally. In addition, there was a 4 day delay in the appearance of tumors (from 15 to 19 days) in mice implanted with A549 cells. Pomegranate fruit extract can inhibit several signaling pathways, which can be used in the treatment of human lung cancer. Besides, the observed increase in NFκB activity during androgen dependence to androgen independence transition in the LAPC4 xenograft model was terminated. These effects were the result of changes in cell cycle distribution and apoptosis induction. Contrarily, in the pomegranate-extract-treated group animals had an increased intracavernosal blood flow, smooth muscle relaxation, and erectile activity compared to controls. In their study, Adhami et al. supplemented drinking water with 0.1% and 0.2% of pomegranate extracts, comparable to 250 to 500 mL of pomegranate juice. Moreover, these studies also showed that pomegranate extracts not only inhibit the activation of NF-κB, but also delay the emergence of castration resistance in a xenograft model through reduced proliferation and increased apoptosis. Pomegranate juice does not significantly increase testosterone levels. If you found this guide on how to boost testosterone naturally with vegetarian foods helpful, share it with a friend who might benefit. With these eight vegetarian ingredients to boost testosterone, you can reclaim your energy, libido, and confidence. Low testosterone doesn’t have to hold you back. These pure vegetarian testosterone-boosting foods are backed by science and rooted in traditional wisdom. Being a vegetarian doesn’t limit your ability to boost testosterone. Although only recently Punica granatum (pomegranate) has been acclaimed for its health benefits, this fruit has long been cultivated and consumed, as a fresh fruit or in the form of beverage, especially in the Mediterranean region. FNP-treated rats showed a marked elevation in testicular levels of thiobarbituric acid-reactive substances, hydrogen peroxide, and protein carbonyl content, as well as the activity of aminotransfer... The goal of the current investigation was to determine how well pomegranate peel extract (PGPE) could prevent the testicular toxicity and oxidative stress induced by FNP. In addition, the potency of the extracts did not vary significantly between control, pomegranate crude extracts and sildenafil. However, the mounting frequency varied significantly between control, pomegranate crude extracts and sildenafil. Despite the exact duration of the trial not being reported, nor were differences in the PSA concentrations among participating groups. In a phase II, cross-over trial, Oh et al. examined supplementation with a mixed antioxidant containing medicinal mushroom extracts, Seronoa repens, and other substances against diethylstilbestrol, among men with histologic evidence of progressive androgen-independent PCa. When men with PCa on AS were used, a combination of genistein, daidzein, and other isoflavones failed to reduce PSA concentrations. In a tertiary prevention placebo-controlled trial, Schröder et al. (Table 9) demonstrated that supplementation with soy, isoflavones, lycopene, silymarin, and antioxidants increased PSA doubling time by 2.6 (from 445 to 1150 days) among men with a history of PCa and rising PSA post-radical prostatectomy or radiotherapy.Testosterone is the “manly” hormone that controls your facial hair, deep voice, muscle growth, and even your sex drive.In cultured human endothelial cells and hypercholesterolemic mice, both pomegranate juice and fruit extract reduced the activation of ELK-1 and p-CREB (oxidation-sensitive responsive genes) and elevated the expression of endothelial nitric oxide synthase.Eating the fruit or drinking pure juice regularly is the best way to get these benefits.As it turns out, a lot of testosterone research is done in the context of breast cancer, because excess testosterone in older women leads to something called aromatase, which converts T into estrogen.And let’s not forget the juice, which has been shown to have three times the antioxidant activity of red wine and green tea.Both total testosterone and free testosterone drop significantly with advancing age. A buddy of mine, always keen to try natural remedies, started incorporating pomegranate juice into his diet. The best way to take pomegranate to increase testosterone is to have it directly in the naturally available form. The antioxidative property of pomegranate does increase testosterone but also combats the availability of free radicals. By inhibiting aromatase, pomegranate antioxidants may help maintain higher levels of circulating testosterone. Several of the fruit’s key nutrients and vitamins are major testosterone boosters. One question that’s frequently asked is whether or not bananas can lower your testosterone. They can also have very potent testosterone-boosting capabilities, according to researchers. As such, pomegranates can help reduce stress as well as the risk of cardiovascular disease, combat viruses, and bacteria (26), and suppress inflammatory arthritis (27). Melatonin prevents deterioration of erectile function in streptozotocin-induced diabetic rats via sirtuin-1 expression. Lutein dietary supplementation attenuates streptozotocin-induced testicular damage and oxidative stress in diabetic rats. Oral supplemen-tation of fucoxanthin-rich brown algae extract ameliorates cisplatin-induced testicular damage in hamsters. Each time you enjoy the rich, tangy flavor, you’ll know you’re enhancing both your health and your vitality. Whenever you find yourself at the grocery store, consider adding a few pomegranates to your cart. Incorporating pomegranate into a balanced diet with other fruits and vegetables is essential. Always consult with a healthcare provider before starting any supplement regimen. To evaluate pomegranate and cacao extracts in humans, researchers gave men aged 36 to 55 either a blend of these extracts or a placebo.Fenugreek seed extracts also demonstrated efficacy for increasing (calculated) FT and BT concentrations.Along with pomegranates, many other foods can support better blood circulation and sexual health.Luteolin (3) also activated StAR expression and resulted in increased progesterone and testosterone syntheses in LC540 tumor Leydig cells .It has one peculiar effect that helps increase free testosterone.If you are wondering what foods are good to boost testosterone then this article is for you.When catechins supplementation was examined, it was not efficient in inducing differences in PSA concentrations of men scheduled for radical prostatectomy compared with controls . Due to its beneficial health effect, it has become a focus of current research . Punica granatum (pomegranate) has been used in ancient medicine to treat various diseases and pathological conditions. Lower concentrations upregulated Th2 (IL-5 and IL-13) and Treg (IL-10) responses as well as CD4+CD25hiFoxp3+ cell frequency. PoPEx (starting from 12.5 µg/mL) suppressed the production of Th1 (IFN-γ), Th17 (IL-17A, IL-17F, and IL-22), Th9 (IL-9), and proinflammatory cytokines (TNF-α and IL-6) in culture supernatants. These studies indicate the chemopreventive effects of pomegranate fruit extract. A vital part of male health is testosterone production, as well as sperm quality. Eating a pomegranate has positive impacts on your cardiovascular health, erectile function, quality of sperm, and testosterone production (just to name a few). However, there was no difference in TC, TG, LDL-C, and HDL-C levels between the PJ and control groups . Findings from an RCT revealed that consumption of PJ (200 ml/day for 6 weeks) in T2D patients significantly decreased TC and LDL-C levels compared to baseline. Pomegranate has anti-inflammatory properties but studies with a longer duration and bigger sample size are required to further evaluate its effect. This study showed antioxidative activity of PJ on serum and on macrophages which could be beneficial for improvement of atherosclerosis in diabetic patients . Also, acute pomegranate extract supplementation enhances vessel diameter and encourages blood flow in the body while ensuring better oxygen and nutritional delivery.In this article, we’ll explore how steroids can affect blood sugar levels, even in people who …Among several other benefits, “MUFAs” can reduce LDL (bad) cholesterol and elevate HDL (good) cholesterol, which we need to convert to testosterone.One randomized, double-blind, placebo-controlled study was conducted examining the effects of a longjack extract (Physta®, manufactured by Biotropics; freeze-dried water extract) on testosterone concentrations (45).Safety depends on formulation, dosage, and individual health status.The study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the Ethics Committee of the Faculty of Medicine, University of Banja Luka, Bosnia and Herzegovina.However, testosterone appears to induce vasodilation at concentrations higher than 10 μmol/L, but at lower physiological concentrations NO seems to be involved in the vasodilatory effect of this hormone .On the contrary, several studies are available on positive effects of pomegranate mouthwash or gel in reduction of dental plaque and gingival inflammation.These findings inspired scientists to screen hundreds of other plant extracts and nutrients for the ability to raise testosterone levels.Vitamin C produced over a 92% improvement in sperm motility, a 100% improvement in sperm count, and a 55% decrease in deformed sperm cells. Another hormone study with pomegranate looked at cortisol, thyroid, and blood sugar levels in patients with Type 2 Diabetes and concluded that pomegranate improved blood sugar, lowered the stress hormone, cortisol in both men and women, but did not impact thyroid levels. In another recent PCOS hormone study conducted in June 2023, they found testosterone levels were lowered for women with PCOS. Boron, according to some recent studies is a vital chemical contributing to the healthy production of testosterone. These phytoestrogens can attach to estrogen receptors in your cells and produce mild estrogen-like effects.A large contributing factor to low libido is declining testosterone levels, which can naturally occur through aging.The toxic effects of CCl4 might affect the suprachiasmatic hypothalamic nucleus (SCN) that may result in the failure of pituitary to secrete FSH and LH and will result in testicular dysfunction leading to infertility .The sea creature is not full of flavors but is considered significant when it comes to boosting your vitamin levels that are essential to enhance testosterone growth.Since then, several longitudinal studies have failed to support a causal role of Se in T2DM, although cross-sectional studies continued to find significant associations between circulating Se levels and T2DM .Moreover, exposure to genistein (6) during perinatal development in male rodents resulted in reduced anogenital distance, lower testosterone serum levels, and decreased testicular mass compared to male rats under a normal diet 55,56,57.And diet’s influence on testosterone levels is significant yet often overlooked. Moreover, in animal studies, the administration of 4-hydroxyisoleucine, an extract from fenugreek seeds, lowered serum cortisol concentrations (77). Asian ginseng also has antioxidant properties, which reduce lipid peroxidation and increase glutathione peroxidase concentrations (74), and it is noteworthy that the only study demonstrating benefits of Asian ginseng recruited individuals with metabolic syndrome (47). Additionally, all studies examining the effect of maca on testosterone concentrations have previously been reviewed by Gonzales et al. (70) and were determined to not affect serum concentrations of testosterone. This meta-analysis included 4 studies (42, 58, 63, 64) but did not include 2 of the studies included in this review because it was conducted in late 2018 and excluded studies with a duration 69) conducted a systematic review on all tribulus studies examining various forms of testosterone in animals and humans and concluded that the evidence indicated that it is ineffective at increasing testosterone concentrations in humans. It is also reported that pomegranate extract reduced markers of platelet activation such as GPIIb-IIIa, p-selectin, and platelet-neutrophil aggregation in 4 subjects with metabolic syndrome . Also, consumption of pomegranate concentrate (50 g for 8 weeks) in obese females with metabolic syndrome led to reduction of glucose, insulin, and insulin resistance and improved markers of metabolic syndrome and cardiac and respiratory endurance . In an RCT, a supplement containing 12 antioxidant fruits including pomegranate was given to 44 males (900 mg/TID for 4 weeks). Incorporating around 300 ml of pomegranate juice into your daily diet doesn't have to be complicated. When you feel better and experience less stress, your body is more likely to maintain a healthy hormonal balance. These antioxidants protect your body against oxidative stress, a condition that can negatively impact testosterone production. Pomegranate juice is a drink made from the seeds of the pomegranate fruit. Maybe you’ve heard a friend rave about its health benefits or seen a headline claiming it could boost your testosterone. This article is in the category Nutrition and created by healthymen Team For more information on hormone health and nutrition, visit our wellness blog. A research done at the University of California confirmed that this juice contains compounds that prevent prostate cancer cells from spreading to healthy tissues of the body. Consuming a balanced diet rich in protein, healthy fats, and vitamins like D and Zinc can support optimal testosterone levels. Consuming 1-2 nuts a day can benefit you as Brazil nuts are a vast source of Selenium, essential for healthy testosterone levels and reproductive health. This finding reveals that selenium ONS is not risk-free and might increase the risk for PCa if taken over-the-counter, uncontrollably. BMI, body mass index; DRE, digital rectal examination; ONS, oral nutrient supplement; PCa, prostate cancer; PSA, prostate-specific antigen; RCT, randomized controlled trials; Se, selenium. His findings revealed that selenium supplementation did not affect the PSA concentrations or the incidence of PCa through a 5-year spectrum. Moreover, a meta-analysis of case-control studies failed to suggest the existence of a relationship between high serum lycopene concentration and PCa risk . Fortunately, men can undergo lifestyle modifications such as testosterone replacement therapy (TRT) or taking a testosterone-boosting diet to increase testosterone production in the body. While old age is a significant contributing factor to a body’s T levels, some medications, health conditions, and body fat can also lead to testosterone decrease. Fortunately, several kinds of food can help to increase testosterone levels. According to medical experts, as we age, testosterone levels in a man’s body fall by 1 to 2% on average. Whilst the Nutritional Prevention of Cancer (NPC) study reported a decreased risk of PCa among Se supplemented men, an increased risk of T2DM was also observed in participants with baseline plasma Se levels in the top tertile . Our study was focused on the protective effect of pomegranate juice against CCl4-induced reproductive toxicity in male rats. Therefore, this study was performed in order to investigate the protective effects of pomegranate juice on CCl4-induced oxidative stress and testes injury in adult Wistar rats. For example, studies in this review, such as Guo et al. (42), identified a significant increase in lean body mass in addition to a significant increase in testosterone concentrations from 12 wk of supplementation with a fenugreek seed extract. Eight weeks of daily supplementation with 2.4 g of a cordyceps extract in 16 healthy men aged between 19 and 25 y did not significantly increase testosterone concentrations compared with the placebo group. Twelve weeks of daily supplementation with 1.0 g of a musali extract in 40 healthy men, aged between 20 and 40 y, did not significantly increase testosterone concentrations compared with the placebo group. Pomegranate-cocoa extract blend shows healthy ageing benefits for men The opposite effects were observed with lower, non-cytotoxic, concentrations of PoPEx. The levels were highest at 200 µg/mL of PoPEx, especially in CD4+ T-cells. The effects of PoPEx on the production of cytokines by PHA-stimulated PBMC. The expression of PD1 on both T-cell subsets (more pronounced on CD8+ T-cells) was upregulated with the two lowest concentrations of PoPEx (6.25 µg/mL and 12.5 µg/mL), followed by its downregulation from 50–200 µg/mL. Autophagy, as detected by acridine orange (AO) staining, was decreased in PBMC culture at concentrations of 50 µg/mL and higher (Figure 3A–C). It is interesting that BCL-2 expression was upregulated in the presence of lower concentrations of PoPEx (50 µg/mL and 12.5 µg/mL) (Figure 2E). With increasing concentration, the percentage of late apoptotic cells dominated over early phase apoptosis. The results presented in Figure 2C,D show that the cytotoxicity in cultures with the two highest concentrations (100 µg/mL and 200 µg/mL) of PoPEx was due to apoptosis. To study the mode of cytotoxicity, an Annexin V-Fluorescein Isothiocyanate/Propidium Iodide (Annexin-V-FITC/PI) staining was used. Several studies have evaluated the effect of pomegranate on oral cavity disorders. Park et al. indicated that the intake of pomegranate vinegar (700 μg ellagic acid/200 mL/day and 1.5 g acetic acid for 8 weeks) by 78 overweight women led to a reduction in visceral adipose tissue and an increase in AMP-activated protein kinase phosphorylation . The consumption of pomegranate extract at a dose of D2 (1.8 g/day) modulated the gut microbiota, reduced plasma LBP, and thus decreased metabolic endotoxemia and cardiovascular risk . In a randomized clinical trial on 49 overweight-obese subjects with hyperlipidemia, pomegranate extract (450 mg) was administrated in two individual doses (D1 (1 capsule/day) or D2 (4 capsules/day) for 3 weeks). The results showed an improvement in myocardial ischemia and myocardial perfusion without any effects on blood sugar, blood pressure, weight, and hemoglobin A1c . In one of our studies, we found that 10 µM of chrysin (1), apigenin (2), luteolin (3), and baicalein (4) (Figure 3) stimulated cAMP-dependent StAR, Cyp11a1, and Fdx1 (Ferredoxin 1) expression in MA-10 Leydig cells .In one study, only nine guys were part of some of the tests.To conclude, pomegranate fruit has anticancer properties that can be attributed to different mechanisms.It is demonstrated that pomegranate fruit extract has an embryonic protective nature against adrianycin-induced oxidative stress (adrianycin is a chemotherapeutic drug used in cancer treatment).Grapes (Vitis vinifera) and grape juice have also been studied in relation to PCa, due to the major phenolic antioxidants content (in grape skin and seeds extract) .Incorporating around 300 ml of pomegranate juice into your daily diet doesn't have to be complicated.However, I will leave it up to the women to decide if their symptoms are life altering or simply irritating and am overall grateful to any researchers conducting research for women's health...Dermatology motivation to stay consistent with pomegranate as medicine!Pomegranate juice may help manage some of these symptoms. The best move towards the avoidance and handling of estrogen-dependent breast cancer is to selectively hold estrogen activity in the affected tissues without compromising its beneficial effects . This is achieved by blocking JNK and ERK-MAPK activation and NF-κB activation in human KU812 cells . Punica granatum peel extract decreased lipid peroxidation in hepatic, cardiac, and renal tissues and at the same time it had a facilitatory effect on the scavenging capability of superoxide anion and hydrogen peroxide . Only about 2% of circulating testosterone is non-protein bound, or free.22 This free testosterone is the biologically active form. Testosterone is a hormone produced primarily in the testes of men and in the ovaries of women. These nutrients can help support more youthful testosterone balance in aging men. However, testosterone... Pomegranate extract, with its rich source of polyphenols, can inhibit IL-1 β-induced activation of MKK3, DNA-binding activity of RUNX-2 transcription factor, and p38 α-MAPK isoform. P38-MAPKs are responsible for regulating cytokine production, neutrophils activation, apoptosis, and nitric oxide synthesis. It is suggested that NFκB activation, MAPK downregulation of COX-2, and mPGES-1 expression were inhibited through a decrease in PGE2 production. It is suggested that urolithins are the main components responsible for the anti-inflammation properties of pomegranate. Testosterone replacement therapy (TRT), on the other hand, was found to significantly increase survival rates of hypogonadal men (15, 16). Also, some evidence exists for another herb and herbal extract, Asian red ginseng and forskohlii root extract. From the 4 databases searched, there were 13 herbs identified in 32 studies, published between 2001 and 2019. Therefore, the use of alternative options, such as herbs, spices, plants, or their extracts, has been explored as a potential treatment option for AD. The study found that in healthy adults, intake of pomegranate juice for just two weeks increased salivary testosterone levels by 23%-27%. A study by Turkish researchers at Firat University found that pomegranate juice slightly increased testosterone levels in rats while improving sperm quality. In one study, researchers found that in healthy adult men and women, intake of pomegranate fruit juice for just two weeks increased salivary testosterone levels by 23%-27%. The aim of this study was to investigate the effects of pomegranate juice (PJ) consumption on sperm quality, spermatogenic cell density, antioxidant activity and testosterone level of male healthy rats. Research published in Endocrine Extracts found that daily consumption of pomegranate juice increased salivary testosterone levels primarily by lowering cortisol – the stress hormone known to inhibit testosterone production. We conducted literature research in electronic databases (PubMed, Scopus, and ScienceDirect) to extract clinical studies on Punica granatum or pomegranate with no time limitation. It seems that consumption of pomegranate juice (PJ) can be applied for prophylactic and therapeutic approaches against COVID-19 . If you have a midnight sweet tooth like me, pomegranate seeds are a deliciously healthy way to curb those cravings. The use of dietary supplements to alleviate side effects of ADT is an attractive approach for the majority of PCa patients. Thus, due to the lack of longitudinal studies, it is currently not possible to determine whether BMD loss beyond the first year of ADT is attenuated. Whilst steady annual declines in BMD among men with normal BMD at baseline were noted, only 38 men with normal BMD at baseline still remained in the study by 3 years . Kramer et al. analyzed the effects of chronic NO3− supplementation on performance during a specific WOD . There are limited studies available regarding the effect of BJ intake on WOD performance. The main finding of this study was that BJ intake improved WOD performance only after the rest time between exercises. Number of repetitions performed after beetroot juice (BJ) and placebo (PL) intake. Foods That May Boost Testosterone Naturally To ascertain convincing evidence of chemopreventive effects of PFE against PCa, its efficacy requires to be evaluated in animal models that closely emulate human disease. Steroids were extracted using ethyl acetate or solid phase extraction, and then analyzed by UPLC/MS/MS. Testosterone and dihydrotestosterone (DHT) are the major androgens detected in tumors. Similarly, the activity of TBARS in the extract treated group was comparable to normal control while showing significant (PdownloadDownload free PDFView PDFchevron_right Groups 1 and 2 were treated with different doses of PA extracts and group 3 received finasteride, all by gavages for forty-five days, while group 4 was left untreated, group 5 served as normal control. According to a recent study conducted in France – it has been discovered that men who are fond of spicy foods have a comparatively higher level of testosterone. These hormones are considered significant for maintaining the reproductive lifecycle of males. However, the level of testosterone production in the testicles does not remain the same. Beyond this, the hormones further play a significant role in maintaining energy levels and bone density. While higher concentrations induce oxidative stress, apoptosis, and inhibited autophagy, non-cytotoxic concentrations of the extract possess significant immunomodulatory activity on PBMC upon stimulation with PHA. Declining testosterone affects up to 40% of men by middle age, contributing to unpleasant symptoms like low energy, reduced muscle mass, and decreased libido. In other cases, however, there is enough data already existing, or corroborating data of studies already conducted, that no further research is necessary. Sometimes a compound isn’t extensively researched because there is no real basis to conduct studies. Only the juice, however, has anthocyanins, a potent plant compound in its own right. Attenuation potentials of royal jelly against hydroxyurea-induced infertility through inhibit-ing oxidation and release of pro-inflammatory cytokines in male rats. Abbaszadeh A, Assadollahi V, Alasvand M, Anbari K, Tavakoli N, Gholami M. Protective effects of royal jelly on testicular torsion induced ischaemia reperfusion injury in rats. Luboshitzky R, Shen-Orr Z, Nave R, Lavi S, Lavie P. Melatonin administration alters semen quality in healthy men. Samir H, Nyametease P, Elbadawy M, Nagaoka K, Sasaki K, Watanabe G. Administration of melatonin improves testicular blood flow, circulating hormones, and semen quality in Shiba goats. Hazelnut consumption improves testicular antioxidant function and semen quality in young and old male rats. A recently published study examined the effects of Tesnor, a proprietary blend of cacao and (Theobroma cacao) seed and pomegranate (Punica granatum) peel, by Gencor, on the sexual function of adult human males. In general, consumption of pomegranate juice/extract may prevent obesity and its related disorders. In a study by Moazzen and Alizadeh, consumption of PJ (500 ml for one week) in 32 patients with metabolic syndrome decreased SBP, DBP, and blood hs-CRP but increased TG and very low-density lipoprotein cholesterol (VLDL) due to the high level of fructose . Conditions like diabetes, high blood pressure, anxiety, and issues with hormonal balance can also affect erections. A balanced lifestyle that supports cardiovascular health, good sleep, stress control, and enough water intake all support sexual health. ED can have many causes, and pomegranate alone may not be enough. Vitamin D is a fat-soluble vitamin that plays a crucial role in various bodily functions, including calcium absorption and hormone regulation, such as testosterone production.You probably think of testosterone as “the sex hormone.” But testosterone plays a number of vital roles in your body, from helping to maintain muscle and bone growth to boosting energy.The pomegranate, when transformed into juice, does some amazing things for the body, and in particular, the cardiovascular system.And that’s why it’s so important you do everything you can to ensure your testosterone continues performing as efficiently as possible.This is achieved by blocking JNK and ERK-MAPK activation and NF-κB activation in human KU812 cells .However, the level of testosterone production in the testicles does not remain the same. They can help improve your reproductive and overall health. Fruits are among the best testosterone-boosting foods you can add to your diet. Vitamin C, on the other hand, increases sex drive and sperm count. Cherries are rich in antioxidants that conversely have benefits for your body. Include horny goat weed, L-arginine, maca, and ginseng to promote blood flow and desire. Men's health supplements come in several forms, each tailored to different goals and biological priorities. According to market research, the global men's health supplement sector is expanding rapidly, fueled by demand for holistic, preventive solutions 3.