Pumpkin seed oil Cucurbita pepo versus tamsulosin for benign prostatic hyperplasia symptom relief: a single-blind randomized clinical trial

Managing blood sugar levels is crucial for preventing and controlling diabetes, and pumpkin seeds can be beneficial in this regard. Antioxidants in pumpkin seeds, such as vitamin E, help protect sperm from oxidative stress, which can damage DNA and impair fertility. The phytosterols in pumpkin seeds also contribute to prostate health by potentially inhibiting the growth of prostate cells and promoting normal urinary function. The other study showed that inclusion of SFO (omega-6) and fish oil (omega-3) improved cryopreservation of rooster semen and positively affected semen parameters post freezing-thawing (Poorvosooghi Gandeshmin et al., 2020). Ezazi et al. (2019), mentioned that sunflower oil (SFO; a rich source of PUFAs) and vitamin C improved the reproductive performance in the rams. The flaxseed oil (omega-3) along with antioxidant improved the reproductive performance of aged roosters (Pasha Zanussi et al., 2019). Thus, it is necessary to increase the fertility rate of such roosters, which apart from the health risks of this operation, the return of sperm to the herd will not be done to the desired level. Roosters were fed on the experimental diets for 60 d and different characteristics of sperm characteristics including routine semen analysis and several sperm functional tests in every 20 d were examined. Along with influencing other health benefits, seeds also play a role in ensuring testosterone availability in blood dreams. As mentioned, seeds are rich in essential minerals, vitamins, and oils needed for overall well-being. Apart from these, fenugreek and other essential seeds also play a significant role in encouraging testosterone levels in men. Miatello et al. (2002) have shown that eNOS activity was decreased by approximately 30% in mesenteric vessels isolated from fructose-fed rats, while Palanisamy and Venkataraman (2013) have reported that eNOS expression in fructose-fed rats was approximately half of that of control rats. Liver hypertrophy and elevated plasma lipid and leptin levels observed in fructose-fed rats may cause a reduction in adiponectin production, decreasing the adiponectin/leptin ratio and adiponectin secretion that would result in hepatic lipid accumulation, confirming the metabolic abnormalities caused by fructose. Moreover, increased levels of circulating insulin and fructose metabolites as a result of HF diets can alter endothelial activity, thereby raising the BP. Similarly, Pérez-Pérez et al. (2017) found that the ambulatory systolic and diastolic BPs in 74 healthy men increased significantly after they consumed 200 g of fructose daily for 2 weeks. Singh et al. (2008) found that the systolic BP of wild-type mice fed a diet with 60% fructose for 12 weeks was 9 mmHg higher than those fed a diet with 60% starch, and that a diet with 60% fructose reduces kidney renin expression by approximately 50% in rats after 2 weeks. Additionally, the presence of potassium contributes to heart health by regulating blood pressure. Its versatility and nutritional benefits continue to make pumpkin a popular and valued crop worldwide. In many cultures, pumpkin is a staple ingredient in soups, pies, and stews, especially during autumn harvest festivals and celebrations such as Halloween and Thanksgiving. Traditionally, pumpkins have been used by indigenous peoples for food, medicine, and even as containers. 1 and Table 1, the hull-less pumpkin seed oil was rich in phytosterols. The pumpkin seed oil was extracted by supercritical carbon dioxide (CO2) fluid and then incubated in ethanolic potassium hydroxide. TPS from hull-less pumpkin seed oil, with ∆7-phytosterols as its main ingredients, is a potential nutraceutical for BPH prevention. One food in particular that may help is pumpkin seeds.

How do you use pumpkin seeds for male fertility?

The development of NAFLD and atherosclerosis was modestly reduced in refined-oil fed mice and virgin-oil strongly decreased liver steatosis, inflammation, atherosclerotic lesion area and disease severity30. To that end, mice were fed with a western-type diet containing cocoa butter (15% w/w) and cholesterol (1% w/w) for 20 weeks to induce risk factors and disease endpoints. An isocaloric switch from a diet rich in saturated fat to a diet rich in unsaturated fat can attenuate non-alcoholic fatty liver disease (NAFLD) and atherosclerosis development. This can include pumpkin flesh, puree, or seeds. In this guide, we will explore what pumpkin is, its nutritional profile, proven health benefits, side effects, ways to consume it, and much more. And diet’s influence on testosterone levels is significant yet often overlooked. Of the 10 included studies, five of them were conducted in USA and two in Iran, two in Brazil, and one in Canada. Using the sensitivity analysis, the individual effect of each study on the overall effect size was examined. In cases with significant between-study heterogeneity, subgroup analysis was applied to find the source of heterogeneity. The Cochran’s Q test and inconsistency index (I-squared) were used to determine the between-study heterogeneity. Links to NCBI Databases Pumpkin seeds aren't just a tasty snack, they also offer numeroushealth benefits for both men and women. Pumpkin seeds offer potential benefits for males, with some studies suggesting they may support male fertility. We have continuous questions regarding potential prostate supplements and ways to keep your prostate healthy. From zinc to antioxidants, these tiny seeds offer a multitude of benefits that can support your body’s hormonal balance. Nowadays seeds have become one of the prominent ways to support overall growth in men and women. Men usually consume supplements with natural sources to boost their testosterone levels and fill them with vitality. Pumpkin seeds appear to affect BPH through the same pathway . Dihydrotestosterone, converted from testosterone by 5α-reductase, is responsible for the overgrowth of the prostate gland which is characteristic of BPH. They used 500 mg Cucurbita pepo seed oil extract capsules twice a day. Intergroup comparisons of baseline characteristics and of their changes after 24 weeks of treatment were performed using the two-sample Student's t-test for continuous variables or the chi-square test for categorical variables. After 12 and 24 weeks of treatment, hair analysis was performed with confirmation of recorded target area. Hair changes including hair counts and diameters were assessed after 12 and 24 weeks of treatment versus baseline by phototrichography (Scalp & Hair Polarizing system, KC Technology, Seoul, Korea). Pictures were taken of the vertex and superior frontal scalp of each patient at baseline and after 24 weeks of treatment using a standardized technique, as previously described . These seeds are nutritional powerhouses packed with lignans, omega-3 fatty acids, zinc, vitamin E, and selenium, all of which play a role in hormonal health. In this study, it was found that daily oral administration of 1 g/kg of pumpkin protein to fructose-fed rats counteracted the high hepatic levels of TBARS and LHP despite lower SOD and GSH-Px activities compared to those fed with C-HF. Unfortunately, despite the improvement in the plasma urea and uric acid levels, our results demonstrate that pumpkin protein treatment increased the absolute kidney weight and did not counteract kidney hypertrophy caused by a HF diet. A component named as D-chiro-Inositol has been recovered from pumpkin which is an insulin secretor and sensitizer (Xiong 2000). Pumpkin is one of the well-known medicinal plants and considered as functional food promoting human health when consumed in safe manners. Pumpkins oily contents consist of omega 6 fatty acid mainly, which has various biological applications as well as considerable antioxidant activity along with hypoglycemic and anti-inflammatory features. Pumpkin based soups and creams could be the easiest prepared possible foods for COVID 19 patients as pumpkins are rich source biologically active components, which can provide relief from disease symptoms (Perez-Alvarez et al. 2020). Study conducted on extracts of pumpkin peels and pulp proved that pumpkin components are capable of exhibiting strong antimicrobial and antioxidant activities (Asif et al. 2017). Sativa seed oil in both doses of 400 and 800 mg/kg may have application in treating BPH by decreasing the concentrations of DHT and PSA, and PI and PV and exerting an antioxidant effect. Sativa oil-treated groups in comparison to the BPH group, which indicates the protective effects of the compounds present in the N. Sativa oil’s effects to inhibit lipid peroxidation and probably its anti-BPH effects are due to the presence of antioxidant and free radical-inhibiting compounds. Sativa seed decreased the serum MDA level, which is consistent with the study by Hosseinzadeh et al. . It's wise to consult a healthcare provider if you have concerns or are on medication. This mineral is crucial for testosterone production. So, why should we care about testosterone? Without enough testosterone, we might feel tired or less motivated. More than 2,000 experienced doctors work and wait for your questions on our site and help users to solve their health problems every day. She believes in going beyond headlines, relying on expert voices and trusted medical studies to inform her work. With over six years of experience in health journalism, she covers everything from disease outbreaks to women’s wellness, nutrition, and fitness. Chanchal is passionate about making health news clear, reliable, and useful. You must consult with your healthcare provider before starting to nullify any potential risks. That being said, these benefits are based on studies and research. What is pumpkin seed oil good for? Is pumpkin seed oil good for the skin? What does pumpkin seed oil taste like? Can you cook with pumpkin seed oil? Sativa seed significantly decreased the PI and PV in BPH. It has been shown that increased prostate weight could be considered a marker to diagnose BPH, while PI is often used to determine the progression of BPH . Sativa oil has essential unsaturated fatty acids (about 1% omega-3, 25% omega-9 and 58% omega-6) in abundance 10,12. The combination of these nutrients makes pumpkin seeds a powerful addition to a balanced diet, particularly for men looking to enhance their overall health. Furthermore, pumpkin seeds are packed with antioxidants like vitamin E, which help protect cells from damage, and they offer a significant amount of protein, aiding in muscle repair and growth. In this article, we will delve into the specific benefits of pumpkin seeds for male health and explore how incorporating these seeds into your diet can lead to a healthier, more vibrant life. In summary, while pumpkin seeds can offer some health benefits, we should be aware of potential side effects and consider our individual health situations. Benign prostatic hyperplasia (BPH) is the most prevalent disease of the prostate in elderly men. The authors have not received any funding or benefits from industry or elsewhere to conduct this study. This graph is a summary of the mechanism speculated from this study. The proposed mechanism of TPS ameliorating BPH in testosterone propionate-induced BPH rat. Conclusively, the seed cycling approach is effective and has significant results in women with PCOS. It was determined that the LH levels were reduced by 1.5%–2% in T2. Among these three groups, the first was the control group (T0). There’s more to pumpkin seeds than just a crunchy snack. Maintaining a healthy diet and lifestyle can help balance testosterone and improve erectile function. Simple steps, such as eating a balanced diet, staying active, maintaining a healthy weight, and controlling blood pressure and blood sugar, often improve not just sexual performance but overall health as well. Omega-3 and omega-6 fatty acids in the seeds also help maintain healthy skin. Pumpkin seeds are a good source of iron and magnesium, which are vital for women’s health, especially in regards to energy levels and bone health. Prior studies on the use of flaxseed or isolated lignan suggest that it may decrease androgen levels and normalize lipid levels; however, most of this research has been conducted in male subjects. Flaxseed, a food generally renowned for its omega-3 fatty acid content, also is one of the richest sources of dietary lignan, having levels that are 800-fold over that of most other foods, (Thompson, 1995). Subsequent research by Morton and colleagues (1997) found that high lignan diets may be protective against prostate cancer, another disorder which is linked to high androgen levels. Lignan also has been found to increase levels of sex hormone binding globulin and thus reduce the amount of free circulating testosterone (Adlercreutz et al, 1987, Martin et al., 1996), though such a reduction has not been observed in all studies (Low et al, 2005). The clinically-significant decrease in androgen levels with a concomitant reduction in hirsutism reported in this case study demonstrates a need for further research of flaxseed supplementation on hormonal levels and clinical symptoms of PCOS. The mean leptin levels were approximately 2 and 1.85 times higher in HF rats than in control rats. Then, the grounded pumpkin seed floor was homogenized with 10 mmol/L of sodium sulfite solution, and the pH was increased to 10 with 1 mmol/L of NaOH. One of these plants are pumpkins, which are used in the treatment of many metabolic disorders due to its components and phytochemicals beneficial for health (Yadav et al., 2010). In addition, elevated levels of total cholesterol (TC), triglycerides (TG), and leptin and lowered adiponectin levels were observed in rats fed a fructose-enriched diet. However, replication will be needed in order to confirm the results of this first-stage study and additional studies are required to elucidate the mechanism responsible for the positive effects of PSO on AGA.

#3 Pumpkin seeds for reproductive health

  • Two of the studies demonstrating positive effects recruited men with no known clinical conditions (50, 62).
  • Studies by Gossell-Williams et al have demonstrated that CP oil inhibited testosterone-induced hyperplasia of the prostate in rats6.
  • Data were tested using two-way analysis of variance (ANOVA) with the type of protein and fructose content as independent variables.
  • Only the subjects with at least moderate symptoms of the urinary tract system but no need of medical treatment were enrolled in the study (IPSS ≥8).
  • Another great benefit of Zinc is how it works to prevent the conversion of too much testosterone into dihydrotestosterone (DHT) in the body.
  • It contains a wide variety of bioactive compounds, including fatty acids, phytosterols, vitamins, etc. (12–14).
  • Do not overdose the seed in your diet, the recommended dosage for adult men is around 1.6 grams (g) of ALA per day.
C, control with 20% casein diet; P, 20% casein supplemented with an oral dose of pumpkin seed protein; C-HF, 20% casein supplemented with 64% fructose; P-HF, 20% casein plus 64% fructose and an oral dose of pumpkin seed protein; F, fructose; NS, not significant. C, control with 20% casein diet; P, 20% casein supplemented with an oral dose of pumpkin seed protein; C-HF, 20% casein supplemented with 64% fructose; P-HF, 20% casein plus 64% fructose and an oral dose of pumpkin seed protein. Interestingly, pumpkin seed protein treatment significantly counteracted alterations induced by fructose improving glucose, insulin, BP, TG, TC, ALT, and ALP levels, increasing liver and muscle glycogen stores, adiponectin level, and adiponectin/leptin ratio, and reducing plasma leptin lev-els. Seed Cycling: The Relationship Between Seeds and Hormones Pumpkin seeds are a versatile addition to our diet and can be easily incorporated into various dishes. Pumpkin seeds offer a wealth of nutrition, making them a fantastic addition to our diets. Pumpkin seeds may enhance fertility, particularly in men, by improving sperm quality. Pumpkin seeds offer a concentrated source of nutrients vital for various aspects of health. The supplementation of poultry diets with omega-3 sources is necessary since they cannot produce the omega-3 PUFAs due to the lack of specific enzymes in their body (Cerolini et al., 2005). In such roosters, sperm quality is reduced, which can reduce fertility to a level that could not be economically valuable for breeders (Safari Asl et al., 2018). The broiler breeder roosters encounter an age-related reduction in reproductive performance which will be highlighted at 45 wk of age onward (Abbaspour et al., 2020). The group 5 (PSO + vitE) had numerically the lowest sperm with fragmented DNA (DNA Fr+) at 0 of the experiment and sperm with non-fragmented DNA (DNA Fr−) was lowest in group 6 (SFO + vitE) on da 40 the experiment. This study was supported, in part, by Sapporo Innovation program. Maintaining healthy levels is important for feeling energetic and confident. They are best seen as a healthy part of a balanced diet and lifestyle. Pumpkin seeds are not just a tasty snack; they’re a powerhouse of nutrients that can support our health in many ways. These little seeds pack a punch with essential vitamins and minerals. Raw seeds generally retain more nutrients, but lightly roasted (without salt or oil) are still very beneficial. Superoxide radicals cannot be dismuted in the absence of the Cu-Zn SOD enzyme, and the increased levels of radicals can interact with NO to form peroxynitrite radicals, eventually leading to the aggravation of cellular injury via membrane damage (Zhao et al., 2015). Increased levels of superoxide anions may reduce NO bioavailability. Rats fed the P-HF diet exhibited higher hepatic and renal SOD and GSH-Px activities but a lower hepatic CAT activity than those fed the P diet. Fructose is readily absorbed and rapidly metabolized in the liver, transformed into fatty acids, and released to the systemic circulation in the form of TG, thus increasing not only the TG plasma levels but also the atherogenic risk (Aydin et al., 2014; Pereira et al., 2017). In addition, several studies have suggested the crucial roles and effectiveness of pumpkin seed oil in the treatment of diabetes, anxiety and even cancer. Furthermore, pumpkin seeds are a source of healthy fats and healthy fats are good for erectile dysfunction because they support cardiovascular health, which is crucial for maintaining erections. Pumpkin seeds may have a positive impact on erectile dysfunction due to their high zinc content, which supports healthy testosterone levels and blood flow. So, whether you're looking for anatural way to enhance your sex life or simply want to improve your overallhealth, make sure to add pumpkin seeds to your diet. After completion of trail period Serum were collected for biochemical analysis again, to determine the effect of seed cycling on women with PCOS. The used dosage was an average dosage based on the previous studies (Farzana et al., 2015; Hanem et al., 2019). Among these three groups, first was control group denoted with T0. The oil from the pumpkin (Cucurbita pepo) seed is claimed to be useful in the management of benign prostatic hyperplasia. PCOS women were treated with seed cycling (flaxseed, pumpkin, sunflower and sesame seeds) improved and significantly reduced ovarian cysts (Irfan et al., 2021). Conclusively, portion control diet and seed cycling has 1.5%–2% significantly reduced prolactin level.

Improves Digestive Health

Pumpkin seeds are rich in zinc, a mineral important for men’s reproductive health and prostate function. Our research reveals an interesting shift in the popularity of pumpkin seeds, with them gaining prominence in various international cuisines. It’s crucial for those with known seed allergies to avoid pumpkin seeds. Hutchins et al. (19) reported that consumption of 5 or 10 g/day ground flaxseed for 7 weeks resulted in reduced estradiol levels in postmenopausal women. They illustrated that flaxseed supplementation could change serum levels of only some sex hormones (17) or even influence the metabolism and urinary levels of some estrogen metabolites (18). Previous studies suggested that the consumption of flaxseed could alter the metabolism of estrogen in postmenopausal women (16). Based on evidence, flaxseed might influence the sex hormone levels due to its phytoestrogens content such as lignans. It is the presence of Linoleic acid and vitamin E in the oil that helps maintain skin barrier function and combat oxidative stress. In this study, we evaluated the effect of the pumpkin seed oil from Cucurbita maxima on urinary dysfunction in human overactive bladder (OAB). The pumpkin seed oil obtained from Cucurbita pepo has been shown to be useful for the treatment of nocturia in patients with urinal disorders in several western countries. Adding pumpkin seeds to your diet is a good way to avoid magnesium-related fatigue or at least rule it out as a cause. “Roasted” pumpkin seeds are not a great source of vitamins, as they are with minerals. They had a 2 weeks’ adaptation before starting d 0, therefore at d 0, they started to eat the experimental diets and the first semen collection was performed at d 0. The analog of vitE source was acetated alpha-tocopherol (Roshd Company, Tehran, Iran), SFO as a source of omega-6 FAs and PSO as a source omega-3 fatty acid (Nina Company, FRICO, Tehran, Iran) were used in the study. Table 2 shows the fatty acid compositions of experimental diets, respectively. In this study, the chemicals were purchased from Merck (Darmstadt, Germany) and Sigma-Aldrich Company (St. Louis, MO). Vitamin E is applied to the poultry diet to prevent from the lipid peroxidation caused by PUFAs (Esmaeili et al., 2014). Diet supplemented with roasted pumpkin seeds showed better PDE-5, ADA, arginase activities, as well as NO and MDA levels. “There is potential for pumpkin seed oil (PSO) to be an effective treatment for hair loss,” says Kristin Draayer, RDN, owner of Kristin Draayer Nutrition and Fitness in Kalamazoo, Michigan. Here, we’ll explore the potential health benefits of pumpkin seed oil — and what the experts say about the available research. Because we know testosterone is helpful in losing weight and building muscle, consuming pumpkin seeds and other testosterone-boosting foods could be very useful for bodybuilders and anyone looking to get lean and strong.
  • Representative photographs of patients at baseline and after 24 weeks of treatment with PSO.
  • In prostate, the activation of EGF receptor and IGF receptor leads to ERK/MAPK activation (35).
  • In an animal study, urinary bladder function was investigated through cystometrogram using anesthetized rats.
  • They are hulled pumpkin seeds, which means the outer white shell has been removed, leaving the green seed.
  • The International Prostate Symptom Score (IPSS) was filled out by the patients at baseline and then 1 month and 3 months after the initiation of treatment.
  • Pumpkins are considered excellent source of provitamin A carotenoids, which are very helpful in prevention of vitamin A deficiency (Kim et al. 2012).
  • It has been observed that people with ample amounts of magnesium in their diet tend to have a higher density of minerals in their bones.
Overall, 9 out of 32 studies demonstrated statistically significant increases in testosterone concentrations. Currently, the primary treatment for AD is testosterone replacement therapy (TRT), which may exacerbate pre-existing medical conditions. This is the first study to evaluate PSO as omega-3 fatty acid with vitamin E on reproductive functions of roosters. Even though LH and FSH were not affected in our study by PUFAs, the end product of the pituitary-hypothalamic axis (testosterone) was increased, which is consistent with the study reported above.
  • Pumpkin seeds are a great source of protein, magnesium and zinc — all very important nutrients.
  • While pumpkin seeds are generally safe for most people, some might experience allergic reactions.
  • Thus, pumpkin seed consumption is highly beneficial for hypertensive patients treated with diuretics that result in a loss of potassium (Arinathan et al., 2003).
  • Always consult with your physician or another qualified healthcare provider with any questions you may have regarding a medical condition.
  • A study conducted by Zhao et al. (2014) on hypoglycemic effect of pumpkin polysaccharides extracted from pumpkin witnessed that the pumpkin polysaccharides can reduce the risk of diabetes.
  • The reductions in androgen levels observed in this case study far surpass those reported with any other dietary intervention conducted to date.
  • They also contain magnesium and healthy fats, which are beneficial for overall health and hormone balance.
The amount of total serum testosterone is significantly impacted by fenugreek extract. Most testosterone-boosting pills combine fenugreek as one of its components to encourage the body’s natural capability to boost testosterone. The research significantly assured that inflammation somehow impacts testosterone production. Being a good source of omega-3 fatty acids improves blood flow and reduces inflammation to boost testosterone. They are a good source of fiber, which can help you feel full and satisfied, and they have been shown to help people lose weight and body fat in studies. The PSA level was measured at screening and at the end of the study. Possible confounding factors on nocturia were controlled. Greatest effects were seen for the end points “incomplete emptying” and “frequency of micturitions with less than every two hours” for which the scores changed on average by 1 score point. The overall compliance of the study product intake was excellent with 100.6%. All subjects were in a stable state before and during the conduct of the study. Smoking can reduce the quality of sperm, cause a lower sperm count and affect general motility (how well sperm swims). Healthy sperm isn’t only the result of good eating habits – it’s limiting a few bad habits as well. They are also a great source of lean, low calorie protein, which has been found to boost fertility in both men and women, plus, free-range eggs are also rich in omega-3 fatty acids. They’re a great source of starch and fibre as well, and because they’re rich in beta carotene, which is an antioxidant, they protect sperm from cell damage. Sweet potatoes are power veggies that are packed with vitamins C, E and folate.
Pumpkin Seed Oil May Improve Prostate Health
Maxima (10 g of oil/day) was orally administrated for 12 weeks. NutritionFitnessCentral.com does not provide medical advice, treatment, or diagnosis. Low magnesium levels causes tiredness and low energy among athletes that could be mistaken for workout fatigue. A 1-ounce serving contains about 153 calories, mostly from fats and protein. Testosterone, its fractions, and binding proteins were all examined in this systematic review. Risk of bias of the included studies was assessed using the Cochrane Collaboration's tool for assessing the risk of bias in randomized trials (30). Each study was scored based upon its risk of bias being low, with some concerns, or high for each criterion. These tiny seeds have been cherished for centuries for their health benefits, and modern research continues to support their role in promoting overall well-being. After cleaning, boil the seeds in water for a few minutes, before patting dry and laying them out to roast. A cup of seeds contains 7.99 mg of zinc; almost 100% of the RDA for women. Despite the academic blanks, it’s well-established that zinc deficiency plays havoc with your testosterone levels. Furthermore, in literature, different external influences are discussed to greatly impact the PSA levels (e.g., sexual activity, cycling or rectal manipulations as colonoscopy, prostate massage, or urinary retention) during the days before blood sampling.27,28 These possibly confounding factors were not controlled during the conduct of the study, so it is unknown if one or more of these interacting factors were applicable to the subjects. A 12-week intervention with the proprietary oil-free hydroethanolic pumpkin seed extract demonstrated a significant benefit on symptomatic BPH as assessed with IPSS questionnaire, bladder diary, and postvoid volume. The reductions in androgen levels observed in this case study of PCOS also exceed those reported with flaxseed supplementations among men with either prostate cancer or abnormal prostatic biopsies. Here are some of the possible benefits of the oil, and what the current research says. Talk to a healthcare professional about whether a supplement is the right fit for your individual health, and about any potential drug interactions or safety concerns. Ricotta is an excellent source of natural whey protein and amino acids, both of which are essential to muscle growth and avoiding the spare tire. You can sneak it into your pancake mix or blend it into protein shakes to reap all the benefits of this magnesium-rich superfood. Magnesium-rich wheat bran helps to boost testosterone, and it works doubly well for those who engage in high-intensity workouts. Evidence from RCT by Chang et al. (17), provides some support for flaxseed’s role in changing estrogen metabolism rather than preventing estrogen synthesis. The mechanism by which flaxseed supplementation could affect sex hormones is, currently, not well understood. One potential source of heterogeneity was the intervention duration; where a short period may not be adequate to elicit significant alterations in sex hormones levels.
  • One subject in the intervention group and one subject in the control group complained of a whole body itching sensation.
  • Besides the hormonal perks, the benefits of eating pumpkin seeds extend to daily energy and immune support.
  • One of the oldest crops, flaxseed has been grown since the dawn of civilization.
  • Three randomized, double-blind, placebo-controlled studies (41, 52, 66) examined the effects of maca on testosterone concentrations.
  • It's wise to consult a healthcare provider if you have concerns or are on medication.
  • Xia et al. (2003) isolated a novel ribosome-inactivating protein (RIP) called moschatin from mature pumpkin seeds and successfully prepared a novel immunotoxin moschatin-Ng 76 which more efficiently than free moschatin inhibits the growth of specific melanoma cells.
  • Pumpkins have numerous health benefits, especially when it comes to fertility.
  • This investigation seeks to examine the effect of pumpkin seed oil on testosterone-induced hyperplasia of the prostate of rats.
  • Eating foods naturally rich in magnesium, like pumpkin seeds, can provide the benefits without the drawbacks.
Overall, 9 out of 32 studies demonstrated significant increases in testosterone concentrations. Two studies used gelatinized maca (41, 52) and 1 study used a dried maca extract (66). Daily supplementation with 800 mg of a tribulus extract for 30 d did not increase testosterone concentrations, while in the Neychev and Mitev study (54) in 21 participants aged 20 to 36 y, a tribulus extract at 2 doses, 10 mg ⸱ kg−1 ⸱ d−1 (3 divided doses) or 20 mg ⸱ kg−1 ⸱ d−1 (3 divided doses), did not increase testosterone concentrations after 4 wk of supplementation. The 1 study that showed no effect of an ashwagandha extract, Shoden®, on testosterone concentrations in men was conducted by Lopresti et al. (51). Pumpkin is an important source of healthy nutrients which includes minerals, dietary fiber, ascorbic acid, carotenoids, tocopherols and phenolics. To maintain healthy body with properly working immune system consumption of pumpkin on daily basis must be encouraged in this current period of post COVID 19. Pumpkin seeds oil which is well known for its nutty taste and smell, greenish color, contains α linolenic acid and oxylipin products. Pumpkin seed oil contains different carotenoid pigments which provide different health benefits, major among these is anti-carcinogenic effect (Jian et al. 2005). It’s advisable to consult with a healthcare professional or a registered dietitian on incorporating pumpkin seeds into a weight loss plan. Additionally, individuals on certain medications, such as diuretics or blood thinners, should consult their healthcare provider before incorporating pumpkin seeds into their diet. By incorporating pumpkin seeds into your diet thoughtfully, you can harness their full potential and enjoy a healthier, more vibrant life. Including pumpkin seeds in a balanced diet can thus aid in regulating blood sugar levels and reducing the risk of diabetes-related complications. Pumpkin seed oil has potent anti-inflammatory properties due to its high content of antioxidants. Phytosterols are plant compounds that can help lower cholesterol levels, promoting better cardiovascular health. Pumpkin seed oil contains phytosterols, which can help improve circulation. I’ve noticed that when my diet includes more zinc-rich foods, I feel more energized and confident. Low testosterone levels can lead to decreased libido and sexual dysfunction in men.
Top 5 Fall Inspired Fertility Foods
This means that testosterone may have a greater physiological effect in the body when concentrations of these biomarkers are elevated. Moreover, fenugreek seed extracts also demonstrated a positive effect on BT concentrations. Similarly, in vitro studies demonstrated reishi's ability to inhibit the activity of 5α-reductase (79, 86, 87). Since cortisol, the body's major stress hormone, is inversely correlated with testosterone concentrations (85), reducing its production may elevate testosterone concentrations. Additionally, pumpkin seeds are a rich source of zinc, a mineral vital for immune system function and cell growth. In this study, TPS, composed of ∆7-phytosterols and ∆5-phytosterols, was isolated from hull-less pumpkin seed oil. In this study, we isolated the total phytosterols (TPSs) of hull-less pumpkin seed oil and analyzed their composition.

Health Insurance

Zinc, in particular, plays a vital role in testosterone production. It’s a rich source of zinc, magnesium, and omega-3 fatty acids. Please book a consultation with me or a qualified healthcare professional before acting on any information presented here. This content is not intended to be substituted or interpreted as medical advice and should not be used to diagnose, treat, or prevent any disease or health concern. Yams can be roasted, or boiled and blended into a soup. Further studies with a larger sample size are required to confirm our findings. The study did not reach the minimal sample size of 35; 6 patients were lost to follow-up in the tamsulosin group and 34 patients remained in this group. They did not specify the Cucurbita species used in their study (29). Targeting this pathway has been the mainstay of medical treatment in BPH. Moreover, they further evaluated patients after 6 months of ttreatment, while we only assessed the results after 3 months. Pumpkin seeds have a plethora of health benefits, including beingtouted as a natural Viagra for men. These seeds areloaded with zinc, which is an essential mineral for the male reproductivesystem. In fact, research suggests that pumpkinseeds may even have a positive effect on erectile dysfunction. Pumpkin seeds have been touted for their numerous health benefits,particularly for men's health. Pumpkin seeds, like all other nuts and seeds, contain certain anti-nutrient properties that make them less digestible and also make the nutrients less available to your body. Pumpkin seed protein powders are available on the market as well if you want to add them to your smoothies and protein shakes. The idea here is to make your testosterone-boosting foods taste good, whilst also enjoying the health-giving benefits as well. Phytosterol beta-sitosterol inhibits the enzyme 5-alpha reductase, which acts to convert testosterone into DHT, and Delta-7-sterine, which appears to block DHT by competing with its receptor sites, like in the prostate and in hair follicles. Without a doubt, a relaxed and elevated mood, as well as being well rested can help to support a healthy sex drive. Pumpkin powder is a concentrated source of β-carotene and it is a store house of phytochemicals which play very important role for improvement of human health. Yellow or orange color of pumpkins are due to high level of β-carotene contents present in them (Kandlakunta et al. 2008). Pumpkins are grown at vast areas of tropical and subtropical states where these are consumed as vegetable in boiled or steamed form or these are processed to make soup and curry. In current COVID 19 outbreak diet rich in carotenoids should be appraised for people of all age of groups in the world (Khalil et al. 2021). Improves Your Prostate Health The oil is loaded with omega fatty acids, antioxidants, minerals, and vitamins. Pumpkin seed oil has quietly made its way from traditional kitchens into modern wellness conversations. Different instruments were used in the study, and data consistently confirm the effects on BPH related symptoms, which are beyond expected placebo effects reported from literature. With a global production of over 10.6 million metric tons in 2006, sunflower oil placed fourth in terms of production behind palm, soy, and rapeseed oil (Stat, 2008). A major oilseed crop farmed around the world is the sunflower seed (Helianthus annuus L.; Stefansson, 2009). Pumpkin seeds are very nutrient‐dense and abundant in nutraceuticals, such as unsaturated fatty acids including palmitic, stearic, oleic, and linoleic acids (Stevenson & Jarillo, 2007). Flax protein supports the immune system and aids in the treatment and prevention of heart disease (Sepidarkish et al., 2019). High levels of estrogen, testosterone, and luteinizing hormone (LH), along with a reduction in the release of follicle‐stimulating hormone, are the hallmarks of PCOS (FSH). Pepo inhibited the prostate size ratio in rats treated with testosterone. Pepo inhibited testosterone-induced hyperplasia of the prostate of rats. Pumpkin seeds are a good source of zinc and fatty acids, which helps regulate and protect your heart function. Pumpkin seeds might relieve some symptoms of benign prostatic hyperplasia, which is a noncancerous enlargement of the prostate. At the end of the experiments, rats were euthanized using a high dose of co-administered ketamine and xylazine. The prostate glands were then removed for further examinations. After 28 days, the rats fasted for 24 h and blood samples were drawn from the abdominal aorta under deep anaesthesia. All groups received repeated testosterone injections for the following four weeks after BPH induction (Fig. 1). Testosterone is an essential male hormone that ensures men have good energy levels, muscle strength, libido or sexual drive and sperm count.” With growing popularity and increasing consumption of different seeds, people have become aware of the importance for regular consumption of seeds. Nuts and seeds have started to get their due recognition for supporting nutrition and wellbeing. The data collected on dietary profiles from 2,884 cases and 5,509 controls using a validated food-frequency questionnaire, which included additional questions related to phytoestrogen-rich foods. At 45 wk of age, when roosters experience reduced reproductive function, treating them with nutrient-enriched diets (especially omega-3 source) will improve their sexual conditions. It is not clear why LH and FSH were not affected, but it is possible that the age of roosters and the time of blood sampling during the day had independent effects on hormonal outcomes. Our findings are inconsistent with the results of Feng et al. (2015), who reported that diets supplemented with PUFAs increase the GnRH pulse frequency in young roosters. Pumpkin seeds are generally high in fibre, which helps prevent constipation in some individuals. Pumpkin seeds are not considered highly allergenic, but you may experience an allergy in rare cases. Zinc boosts immunity and helps the baby grow healthy. Pumpkin seeds are rich in magnesium. Magnesium in pumpkin seeds helps regulate blood pressure. There are many benefits to eating pumpkin seeds. Is pumpkin seeds good for erectile disfunction Store pumpkin seeds in an airtight container in a cool, dry place, away from direct sunlight. Regular consumption of pumpkin seeds can help strengthen the immune system, making the body more resilient to infections and illnesses. Pumpkin fractions like peel, flesh and seeds are capable of imposing in vitro pharmacological role in animals and humans as these constituent parts are loaded with bioactives (Hussain et al. 2022a). In clinical trials it was proved that oral treatment of chemically induced diabetic rats with omega 6 fatty acids, restored the anti-oxidant status to normal range in various tissues (Suresh & Das 2003). Experiments on streptozotocin-induced diabetic rats, with application of pumpkin extracts provided effective results to lower down the blood glucose level (Xia & Wang 2007). Pumpkin seeds have satisfactory levels of healthy fats, protein and iron that helps in sustaining energy levels. Additionally, regular consumption of pumpkin seeds can avert the risk of prostate cancer by providing protection against oxidative stress. As increased estradiol production was reported in MCF7, BeWo, and Jeg3 cells in a concentration dependent manner, Richter et al delineated the effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells38. These studies demonstrated that patients treated with pumpkin seed oil, saw palmetto oil, or a combination of pumpkin seed oil and saw palmetto oil for over 12 months have improved in BPH symptoms compared to the patients on placebo. Ours was not a randomized, double-blind, and placebo-controlled study design. As for the study design, it was an open-labeled trial because of excessive amount of oil volume required for encapsulation. Moreover, more than 96% of the patients had no undesired side effect due to treatment with the oil. Moreover, the levels of serum prostate-specific antigen (PSA) in all males were within normal range. Aghaie et al. (2016), showed that PSO improved semen parameters in adult male Sprague-Dawley rats. The increased sperm count and the decreased DNA fragmentation were observed by supplementing PSO in the human trial (Elfiky et al., 2012). The supplementation of omega-3 from 48 to 58 wk of age is also promising on sperm quality and fertility in turkey breeders (Blesbois et al., 2004). The omega-6 fatty acids are positively related to the sperm motility in chicken also even if present in small proportion (Cerolini et al., 2005).
  • Because they have zinc, magnesium, and arginine, and they can enhance testosterone levels, improve blood flow, and relax blood vessels.
  • Understanding the full scope of their nutritional benefits and how to properly incorporate them into our meals is central to reaping their health rewards.
  • Sperm characteristics of roosters fed with fatty acid sources with or without vitamin E.
  • Foods rich in zinc include oysters, beef, crab, lobster, pork, chicken, pumpkin seeds, yoghurt, and lentils.
  • These seeds are not only versatile in use but also carry an impressive nutrient profile that contributes to heart health, sleep quality, and overall wellness.
  • Studies by Bourre et al have further brought the importance of oleic acid, a monounsaturated fatty acid also present in pumpkin in reducing the susceptibility of the testis and epididymis to lipid Peroxidation23.
  • In addition, the serum MDA levels decreased significantly in N.
When we stack pumpkin seeds against other seeds, they hold their own quite well. When we think about pumpkin seeds, we often overlook just how nutrient-rich they are. A small, consistent amount each day will deliver all the benefits of pumpkin seeds without the potential downsides.
  • That's right – these small but mightyseeds are packed with nutrients that can enhance male libido and improveoverall sex drive.
  • How quickly you break them down, and whether you break them down into things that block the good effects, can shape how your hormones are working.
  • A 12-week intervention with the proprietary oil-free hydroethanolic pumpkin seed extract demonstrated a significant benefit on symptomatic BPH as assessed with IPSS questionnaire, bladder diary, and postvoid volume.
  • Not everyone should munch on pumpkin seeds.
  • Sativa seed significantly decreased the PI and PV in BPH.
  • It is the phytosterol content of Cucurbita pepo seed oil that appears to interfere with the function of dihydrotestosterone produced by 5α-reductase which plays a major role in the process of BPH .
OABSS, a self-assessment of OAB symptoms, is recognized as a standard tool for diagnosis and evaluation of the severity of OAB, and has been used in clinical studies. Four subjects quit the entry on their own, and three subjects were excluded because of inadequate intake of the oil. Demographic and medical data were obtained from the medical records and interviews at study entry. All protocols in this study were approved by the Ethical Committee of Hokkaido Information University, and written informed consent was obtained from all participating subjects. It provides essential nutrients like vitamin A, vitamin C, and iron that support fetal development and immunity. Yes, pumpkin is safe and beneficial during pregnancy. What is pumpkin called in India? Yes, pumpkin is low in calories and high in fiber, which promotes fullness and supports weight management. Is pumpkin good for weight loss? In this blog, we’ll discuss details about the best testosterone-boosting seeds and their incredible benefits to support overall well-being. In line with our findings, Vahlensieck et al. demonstrated a clinically relevant reduction of IPSS compared to placebo after 12 months of taking pumpkin seed extract . In previous studies, Vahlensieck et al. and Friedrich et al. used 1000 mg of pumpkin 13, 14; however, with the available dose per capsule in our study, taking 3 capsules (1080 mg) could have reduced patient compliance. Thus, in the current study we aimed to compare the effects of Cucurbita pepo with tamsulosin for the treatment of BPH symptoms. In this study, β-sitosterol only accounts for 8.17% of TPS, and ∆7-phytosterols reached up to 87.64%. Phosphorylation levels of ERK, JNK, and p38 were analyzed by western blotting. (A) Relative mRNA expression of proliferation-related growth factors IGF, EGF, bFGF, and TGF-β1; (B) relative Bax/Bcl-2 mRNA expression and Cleaved-Caspase 3 protein expression. After treated with testosterone propionate, the mRNA relative expressions of growth factors insulin-like growth factor (IGF) and epidermal growth factor (EGF) were markedly increased (Fig. 4A). With its high antioxidant and fatty acid content, pumpkin seed oil helps improve skin elasticity, moisture, and repair. Unlike regular cooking oils, pumpkin seed oil is usually consumed raw to preserve its nutrients. Because it is minimally processed, pumpkin seed oil retains more nutrients than many other oils. What makes pumpkin seed oil so special? Furthermore, there was also a positive effect on objective measures of BPH symptoms (e.g., postvoid volume) which also demonstrated a health benefit for EFLA 940, the oil-free hydroethanolic pumpkin seed extract. Mean square (Table 6) for effect of seed cycling and portion control diet has significantly changed prolactin level. Conclusively, portion control diet and seed cycling has 0.5%–1% significantly reduced TSH level. Furthermore, our findings were similar with several other studies that have shown a decrease in LH levels by seed cycling. It is clear from mean squares (Table 4) that seed cycling has significantly affected LH in all studies except in women with PCOS in control group. Is pumpkin seed oil good for hair growth? Making pumpkin seed oil at home is possible but requires patience. Because of its magnesium content and effect on serotonin, pumpkin seed oil can support emotional balance and relaxation. For soups, a handful of pumpkin seeds work as a garnish, providing a pleasantly nutty flavour and polyunsaturated fat, which is beneficial for heart health. Fibre in pumpkin seeds promotes digestive health by aiding bowel regularity and preventing constipation. Including pumpkin seeds in our diet can help reduce inflammation related to various chronic diseases. The reference lists of relevant papers were also examined to locate additional studies that were not identified by the initial database search. However, the review of Clemesha et al. (28) had several limitations such as using only a single search term, “testosterone booster,” using only Google to search for existing research, and examining only the top 50 supplements. A recent narrative review by Clemesha et al. (28) concluded that many supplements claiming “testosterone-boosting” properties, including formulations using herbs, spices, plants, or their extracts, do not appear to be supported by scientific evidence. If you’ve noticed changes in your daily routine, energy, or comfort, our carefully blended formula offers a simple, natural way to stay on top of your health. By working with the body’s natural processes, this formula helps men feel more in control, day and night. Our Saw Palmetto Plus Pumpkin Seed & Zinc formula is crafted for individuals seeking comprehensive support for men's health. Magnesium is a nutrient that helps to control blood pressure, regulate muscle and nerve function, and helps to create cells. The prostate gland is responsible to create prostate fluid, which is important for ejaculation. Pumpkins utilization has different forms, like fresh pumpkin, boiled, cooked, in the form of powders, extracts, purified bioactives and pumpkin based functional and pharma food products. Research conducted by Chen et al. (2020a, 2020b) provide useful information for understanding the inhibitory effects of polysaccharides from pumpkin flesh, on LDL oxidation. Quanhong et al. (2005) reported that hypoglycaemic effect of pumpkin is due to protein bound polysaccharides which were isolated from water soluble substances of pumpkin fruits. Because of low energy value dietary fiber obtained from pumpkin pulp is very helpful in lowering blood glucose level (Jun et al. 2006). A study conducted by Zhao et al. (2014) on hypoglycemic effect of pumpkin polysaccharides extracted from pumpkin witnessed that the pumpkin polysaccharides can reduce the risk of diabetes. At the end of the experimental period, all rats were sacrificed by sodium pentobarbital anesthetization (25 mg/kg BW, i.p.) followed by cervical dislocation. TPS was dissolved in corn oil and orally administered to the mice (1 mL/day/rat), while the NC group were treated with the vehicle. They were allowed for acclimation under climate-controlled conditions for 7 days before the experiments began. The rats were housed in a pathogen-free room maintained at a temperature of 23 ± 1°C and relative humidity of 70% with an alternating 12 h light/dark cycle. The peaks were then tentatively identified from their retention characteristics and mass fragmentation patterns after initial pretreatment by using NIST.14 mass spectrum database. Also, employing optimum Vitamin B6 levels and other essential minerals like Magnesium, ensure testosterone levels in men. It is well proven that vitamin B6 deficiency somehow impacts testosterone as well as other bodily functions. They include a good quantity of B vitamins, which provide a variety of health benefits. What is Pumpkin Seed Oil? A serving size sprinkled into homemade granola or trail mix can elevate the energy yield through its mix of healthy fats and carbohydrates. Consistent intake of fibrous foods like these seeds supports overall digestive wellbeing. They are rich in magnesium, which aids in maintaining a healthy blood pressure. Loaded with antioxidants, these seeds contribute significantly to our wellbeing. Be aware of food safety issues surrounding recalls of foods, as these sometimes will include seeds. Pumpkin seeds offer a range of benefits for health, and we’ll address some common queries to help you understand how they can fit into a healthy lifestyle. Packed with vitamins, minerals, antioxidants, and fatty acids, these seeds offer a myriad of health advantages. These healthy seeds make a great snack, or you can add them to dried fruit and nuts to create a trail mix or add them to breakfast cereals and yoghurt. Sunflower seeds are rich in vitamin E, an essential nutrient shown to boost sperm count and sperm motility.
  • Dr. Pranitha Bangera is a gold-medalist healthcare professional with an elite foundation in clinical training and patient care.
  • Healthy fats, such as monounsaturated and polyunsaturated fats, are essential for overall health and well-being.
  • With its high antioxidant and fatty acid content, pumpkin seed oil helps improve skin elasticity, moisture, and repair.
  • Means of sperm viability in aged roosters fed diets during 60 days’ experiment.
  • In our lab, biochemical analysis has been carried out to identify the molecules responsible in the pumpkin seed oil to alleviate urinary tract problems, but it remains to be elucidated to date.
  • The World Health Organization (WHO) estimates that zinc deficiency affects 31% of the global population.
Pumpkin seeds benefit bone health because they are rich in proteins and fibre. Pumpkin seeds are good for our immune system due to the presence of vitamin E and zinc. Pumpkin seeds contain significant amounts of zinc, which is known to support testosterone production. Pumpkin seeds are a valuable source of zinc and antioxidants, both of which are critical for male reproductive health. Pumpkin seeds, often overlooked as a simple byproduct of the pumpkin, are nutritional powerhouses packed with essential vitamins and minerals.
  • Targeting this pathway has been the mainstay of medical treatment in BPH.
  • The volunteers ingested one tablet daily (500 mg of the extract, corresponding to 350 mg native extract and equivalent to 10 g of pumpkin seeds per tablet) before going to bed.
  • I’ve noticed that when my diet includes more zinc-rich foods, I feel more energized and confident.
  • People allergic to pumpkin seeds may show symptoms like headaches, itching, rashes, difficulty breathing, etc.
  • In these studies, authors demonstrated that CM oil was safe, well tolerated and was effective in preventing urinary disorders such as Overactive bladder (OAB) and benign prostate hypertrophy (BPH).
  • Increased levels of superoxide anions may reduce NO bioavailability.
On the other hand, adding vitamin E to the diet has been reported to have a positive effect on total motility and progressive motility of rooster sperm (Amini et al., 2015). The results of this study confirm that maintaining the antioxidant status of sperm membranes by using antioxidant vitamin E increases sperm motility and survival. The reason for choosing vitamin E in this study was that vitamin E is one of the major antioxidants in sperm that has been widely identified in sperm membranes and it protects the sperm cell from oxidative damage (Benedetti et al., 2012). Pumpkin seeds contain tryptophan, an amino acid that helps produce serotonin and melatonin. The oil is loaded with carotenoids and vitamin E, which help protect cells from oxidative stress and inflammation. Some studies show oil can reduce overactive bladder symptoms and improve urinary frequency. This oil is famously known for supporting prostate function.
1.3. Thyroid stimulating hormone (μIU/mL)
These treatment strategies include lifestyle alterations, medical therapy, and surgical treatment . There is a variety of treatment strategies for BPH symptoms depending on symptom severity, together with patient discomfort and preference. Benign prostatic hyperplasia (BPH) is a common age-dependent chronic disease that results from the progressive enlargement of the prostate gland due to the non-malignant proliferation of epithelial prostate cells and smooth muscle cells .

Supports Immune Function

Furthermore, these animal models not only developed hypertension but also had decreased levels of plasma ascorbic acid, glutathione, calcium, iron, and albumin compared to those of the controls. As shown in Table 4, an HF diet caused several metabolic abnormalities in rats. Absolute and relative liver and kidney weights of experimental and control rats Pumpkin seed protein administration decreased the absolute liver weights of the P and P-HF groups by approximately 22% and 31%, respectively, compared to those of the C and C-HF groups. Therefore, pumpkins seeds would go well with vitamin-rich food sources, such as fruits. Pumpkin seeds are a great source of protein, magnesium and zinc — all very important nutrients. A study published in the Journal of Clinical Endocrinology & Metabolism found that zinc deficiency can significantly lower testosterone levels (Prasad, 1993). Achu et al. (2013) reported that all Cucurbitaceae family oilseeds are rich source of some essential amino acids and gives protein digestibility. Focus on Heart Health Two of the studies demonstrating positive effects recruited men with no known clinical conditions (50, 62). Three out of 4 studies also demonstrated positive effects on (calculated) FT (53, 58, 63), and the 2 fenugreek studies that included BT as an outcome measure demonstrated positive effects (53, 64). Four of the 6 studies demonstrated increased testosterone concentrations with fenugreek supplementation (42, 53, 58, 64), while 2 studies (57, 63) showed no effect of supplementation (Table 1). The initial search identified 4384 unique studies, of which 32 randomized controlled trials were identified as eligible following assessment using the selection criteria (Figure 1) (35–66). The inclusion of the testosterone fractions and binding proteins were deemed important since only ∼2% is “free” testosterone, with the remaining testosterone “bound” to proteins (predominantly SHBG, ∼40–45%) (31–33) and controversy existing regarding the relative importance of “bound” and “unbound” testosterone (34). Amino acid studies of some pumpkin verities revealed that amino acid profile contain high amount of glutamic acid ranging from 33.03 to 34.76 g/100 g protein (Al-Anoos et al. 2015). Pumpkin seeds also contain antimicrobial protein among these are three basic proteins MAP2, MAP4 and MAP11 with molecular weight 2.2 kDa, 4.6 kDa and 11.7 kDa respectively are observed having inhibitory effect on the growth of yeast cells. Molecular docking study has revealed that from seed proteins during digestion,1593 peptides were released out of which, 36 were of high gastrointestinal absorption. Just don’t char them — high heat can destroy some of the sensitive oils and minerals. Ayurvedic traditions even suggest consuming them before bed with warm milk for sexual and reproductive health support. Because hey — better health is better when shared. If you found this helpful, pass it on to someone who could use a little natural health boost too. They also contain magnesium and healthy fats, which are beneficial for overall health and hormone balance. If you’re looking to up your testosterone, it’s best to combine a balanced diet, regular exercise, and good sleep. When testosterone levels are balanced, we feel more energetic and confident. Whether raw or roasted, always go for high-quality, non-GMO and organic seeds when possible. General characteristics of the study population Patients were asked to fill out the International Prostate Symptom Score (IPSS) for the assessment of BPH symptom severity, before treatment and then 1 and 3 months later. Thus, patients in the pumpkin group received 2 capsules a day (720 mg). The reason for choosing this dose and type of pumpkin (Cucurbita pepo) was that it was the only form and dose available in the Iranian market. Initially, 80 patients were eligible to enter the study.