It’s because of the sexual benefits of Mondia whitei that the supplement is used as a tonic in many communities. This African Herb that boosts testosterone is also found to have anti-inflammatory and antioxidative properties. Also known as African ginger, Mondia Whitei is a plant native to Africa. Along with this, it also improves the level of reproductive hormones like follicle-stimulating and luteinizing hormones which leads to the production of more testosterone. It is a popular traditional aphrodisiac and testosterone booster in South and South-Eastern Africa. Some herbs work by increasing blood flow, while others modulate hormone levels or reduce stress-related performance barriers. The study revealed enhanced outcomes in desire, arousal, erection quality, orgasm intensity, and overall sexual satisfaction. Herbal remedies function through intricate pathways that address sexual performance challenges at their root. These natural compounds work through complex interactions within the body’s systems to support sexual health and vitality. For those interested in exploring natural approaches to sexual wellness, our guide on natural male enhancement provides additional insights into safe and effective solutions for 2025 and beyond. While many of these products say they can increase sexual desire or performance, it’s unclear if they are safe or actually work. Sexual enhancement supplements are a subset of dietary supplements, specifically marketed to address issues related to sexual health and performance. Male sexual enhancement supplements may not be safe for everyone as they can cause side effects, allergic reactions and interactions with other medications. The beneficial effects have been scientifically evaluated and confirmed in meta-analyses of randomized clinical trials.6 For example, in a double-blind, placebo-controlled study, 45 men with moderate to severe erectile dysfunction had found improvement in their scores on erectile performance and sexual satisfaction after treated with three times daily doses of 900 mg Korean red ginseng for 8 wk.7 A similar study on 60 men with erectile dysfunction also reported marked improvement in erectile function including rigidity, penetration, and maintenance of erection after taking Korean red ginseng (1000 mg) three times daily for 12 wk.8Predictive factors for obtaining PDE-5i while avoiding interaction with healthcare professions were embarrassment and the perception that it would be cheaper to get the medicine through alternative means.Unlike cordyceps, astragalus is better to take daily to get the most health benefits.Tortuosum has been marketed for the treatment of mild depression and to improve mood .Herbs For Men’s Health, with their time-tested benefits, emerge as a promising solution forvarious Men’s health challenges.These benefits have been justified by the effects of medicinal plants on both the central nervous system and the reproductive tract.Ligusticum chuanxiong Hort is planted primarily in southwestern China, which is usually used to promote blood flow and alleviate pain.Subjects and female partners in the VXP group reported significantly higher (P 4).The anxiety can add to erectile dysfunction. Table 1. Common medications and dietary supplements with interactions with phosphodiesterase-5 inhibitors (PDE-5i). In addition, this study has also summarized the effects of different herbal interventions which will serve as an ideal approach to optimize the therapy based on the effect size and might be useful in optimizing the cost of therapy as well. Along with all the limitations, our systematic review is the first study establishing a comparison among all available herbal interventions regarding male infertility, and this comprises a very significant aspect of this work. All of these adverse effects were spontaneously resolved and were assumed to not be related to the use of herbal products. Those that act as Testosterone releasers have some value especially if the male has andropause and those containing some-pick-me-ups and energizers like Ginseng helps the tired and fatigued male and possibly those with asthenia. These herbals can be found throughout Asia and range from Eurycoma longifolia (Tongkat Ali), Ginseng and Tribulus etc. Valerian used as a fresh plant liquid extract can work in this manner; Yet, only 10% of these 100 million, i.e., 10 million are opting for treatment, despite enormous advancements and treatment facilities in all parts of the world (2). Doctors may recommend supplements in specific situations where patients are not getting enough nutrients from their diet or have a certain health condition. “Don’t be afraid to bring up a sexual health concern,” says Dr. Simone. These products may not have evidence to back up their claims, and they could also lead to unwanted side effects. With traditional health practitioners, pharmacists, orthodox medical practitioners,nurses, botanists, chemists, pharmacologists, toxicologists and other scientistsworking together collaboratively for a common purpose, the future of scientificallydeveloped, affordable, safe and effective natural medicines for ED will certainly bein sight. Icariin could inhibit PDE5 activity and preserve the expression of NOS, thereby increasing the cGMP levels in spontaneously hypertensive rats (40). Berberine is a benzodiozoloquinolizine alkaloid first extracted from the rootstalk of rhizoma coptidis and now is found also in other Chinese herbs such as phellodendron and radix berberidis. Panax notoginseng saponins are the effective ingredients of Panax Notoginseng and are often used to treat cardiovascular or cerebrovascular diseases. In addition, 3,5,7,30,40-pentamethoxyflavone (PMF) isolated from Kaempferia parviflora was reported to cause relaxation of human cavernosum in vitro by voltage-dependent Ca2+ channel (35). It was reported that tetrandrine could inhibit the Ca2+ influx from extracellular matrix and Ca2+ release from intracellular calcium pool in corpus cavernous smooth muscle cells (31). Pruriens significantly improved T, LH, dopamine, adrenaline, and noradrenaline levels and reduced levels of FSH and PRL in infertile men. Pruriens largely accounts for prospermatogenic properties . The recovery is mediated by reduction in ROS level, restoration of MMP, regulation of apoptosis, and eventual increase in the number of germ cells and regulation of apoptosis. For example, the Zulu peopleof South Africa have, for centuries, used the roots of Eriosema species as a remedyfor the treatment of erectile dysfunction and/or impotence.Therefore, the aim of this study was to evaluate the medicinal plants that affect sperm and testosterone production in men.In addition, icariin was reported to increase the circulating testosterone level in rats with damaged reproductive system (42).Problems getting or keeping an erection can be a sign of a health condition that needs treatment and a risk factor for heart disease.The European Association of Urology has recently reported the use of complementary treatments based on traditional medicine as a multidimensional integrative approach to male infertility treatment (9).Natural substances are mistakenly believed to be a safer alternative to modern medications with no side effects.It has been estimated that approximately six million men in the EU purchase these products from the Internet .Besides it also boosts DHEA-S levels which are steroid hormones involved with testosterone production by converting estrogen into testosterone. Ginseng and male reproductive function I’ve researched and tested numerous herbal supplements designed specifically for men’s health needs. These plant-based remedies may provide benefits ranging from improved prostate function to increased energy. Common ingredients include herbs like Panax ginseng, maca root, and Tribulus terrestris, as well as the amino acid L-arginine and various vitamins and minerals. While some products may contain seemingly harmless vitamins and herbs, others have been found to contain undisclosed prescription drugs or other dangerous ingredients. Given these risks, it is crucial to speak with a healthcare professional before taking any over-the-counter male enhancement supplement. If you are taking turmeric supplements, it is important to talk to your doctor first, especially if you have any underlying health conditions or are taking any medications. Fenugreek is an herb that has been used for centuries herbs for men’s health. Nettle root is an herbs for men’s health that has been traditionally used to support men’s health. It is particularly beneficial for promoting vitality and sexual health. When it comes to herbs for men’s health, Horny Goat Weed stands out as a natural remedy with remarkable benefits. The study eligibility criteria involved clinical trials and case reports that encompassed men submitted to TT supplementation alone and that assessed serum androgen levels or sexual function. Saponins from TT also act directly as a neurosteroid, increasing dehydroepiandrosterone levels, which may exert an antagonistic effect on gamma aminobutyric acid (GABA) and thereby enhance sexual function regardless of testosterone levels . Some studies indicate that TT supplementation modulates androgen profile through an increase in serum testosterone levels and the testosterone/estradiol ratio 8,9. Therefore, only 2 studies showed significant intra-group increase in total testosterone levels, which had low clinical magnitude (60–70 ng/dL) and involved subjects with hypogonadism. As expected, all the plants involved are libido-enhancing aphrodisiacs altering neurotransmission, although ginseng (P. ginseng and P. quinquefolius) and yohimbe (P. johimbe), and kanna (S. tortuosum) also enhance sexual potency. Although the plant contains a variety of indole alkaloids related to ibogaine, a well-known psychoactive substance from iboga (Tabernanthe iboga Baill.) that has also been used as an aphrodisiac , there is no evidence of positive effects on sexual function. Positive effect in insomnia, anxiety, chronic stress, weight management, thyroid gland function, telomerase, cardio-respiratory endurance, muscle strength, recovery of male and female sexual function, and senescence was demonstrated in preclinical and clinical studies . Maca is an edible herbaceous plant of the Andes Mountains and has been used for centuries for improving male and female sexual function. The native communities have used its roots and barks as a treatment for depression, sexual dysfunction, and as a “nerve tonic” . Mucuna pruriens, also known as velvet bean, is a legume that grows in the tropics that has a long history of use for male health."What I see in maca is a means of normalizing our steroid hormones like testosterone, progesterone and estrogen. Therefore it has the facility to forestall the hormonal changes of aging." Dr. Gordon believes.Although the used plants have a long popular tradition, very often there is a lack of scientific data in relation to their efficacy .Superba alcoholic extract (0.01, 0.1 or 1.0 mg/kg BW/day) for 6 months treatment significantly increased the sperm concentration and delayed the decreased motility with time.Lifestyle changes can be effective in treating sexual problems.A total of 62 patients were randomized into a treatment and a control group.Both the fruit and root of the plant have long been used in Traditional Chinese Medicine and Ayurveda.Early phase II studies suggest potential benefits, but these agents are not yet represented in mainstream CVS offerings. Others have vasodilatory properties, which enhance blood flow and cardiovascular health. Herbs for men’s health offer a natural and holistic approach to addressing men’s health concerns. By taking care of themselves physically, mentally, and socially, men can live long and healthy lives. There are many things that men can do to improve their health at any age. Some herbs claim to help erectile dysfunction. TT supplementation at doses of 400 to 750 mg/d for 1 to 3 months improved erectile dysfunction in 3 of the 5 studies that assessed this parameter. Their scores on the International Index of Erectile Function-5 (IIEF-5), a standard measure for erectile dysfunction, increased from an average of 11.2 to 17.9. Ginger increases testosterone and sperm health in some studies. Panax ginseng shows promise in treating erectile dysfunction. ED is one of the most common sexual problems men experience.They can help you choose the best options for your specific health needs and goals.A number of plants have been discussed in detail and a few others are only tabulated; a major criterion for this arrangement was the ethnopharmacological relevance of the plant in the Ayurvedic system of medicine.We present a case report of an individual with bipolar disorder and hypersexual behavior who became victim to over the counter sexual enhancement products/supplements which caused serious health and life threatening consequences.It has been used basically for treating ringworm, swelling of women’s genitals and male impotence.This review, while evaluating various factors that control sexual function, identifies a variety of botanicals that may be potentially useful in treating sexual dysfunction. Others seek to bypass the legitimate healthcare system due to either embarrassment of the underlying condition or desire for cheaper alternatives. Counterfeiters are taking advantage of this growing market by developing illicit and counterfeit PDE-5i products. Herbs like Muvevha, Mufunguri, and Bangalala have long been used in southern Africa as natural solutions for male enhancement. Concerns about synthetic products or surgery drive interest in traditional methods, which are perceived as safer and more affordable. Yohimbine is generally believed to enhance central sexual impulse by blocking the alpha-2 adrenoceptors in the locus coeruleus in the brain .Due to various complications reported about the use of chemical sexual drive enhancers, HBS can be introduced as an alternative with fewer side effects.Whereas, Nutmeg treated male animals mated 3 females each except 2 which mated 5 females each.Relaxation of the trabecular smooth muscle of the corpus cavernosa leads to a decreased vascular resistance and increased blood flow to the penis.Increasing household income and availability of a sexual partner positively correlate with their legal use (15).Poor sleep reduces testosterone production and impairs endothelial function, while hypertension and atherosclerosis diminish blood flow to the corpora cavernosa.Acupuncture treatment was reported to be beneficial in one included study in the results . It is therefore essential that patients with sexual dysfunction either of psychogenic or organic aetiology should avoid taking such herbal products which may have adverse effects on their mental state. Currently, yohimbine-containing products are advertised on the Internet not only for treating erectile dysfunction and enhancing sexual performance, but also as a fast weight-loss and body-building supplement 15–17. These products are advertised on the Internet as “natural” and “safer” alternatives to pharmaceutical products, such as gold standard for treatment of erectile dysfunction and the phosphodiesterase type 5 (PDE5) inhibitors (e.g., sildenafil, tadalafil, and vardenafil). Sildenafil citrate (Viagra™) and related sexual stimulant ‘love’ drugs havebeen widely studied for their tolerability, safety and efficacy in the treatment oferectile dysfunction in a variety of patient populations. It has remained one of the major global health issues which is usually attributed to age, diabetes mellitus, smoking, cardiovascular diseases, kidney disease, previous operations, psychological factors, and drugs 2, 3. The plant species that represented the highest number of citations were Asparagus africanus, succeeded by Ricinus communis and Carissa spinarum. Accordingly, fifty-four published articles and thesis papers were finally included in this study. Electronic databases of PubMed (Medline), Google Scholar, and grey literature were employed to access the studies. Traditional Chinese medicine (TCM) has a rich history of using herbs to address ED and promote overall vitality. Erectile dysfunction (ED) is a condition that affects millions of men worldwide, leading to emotional distress, relationship challenges, and diminished quality of life. It’s also said to accrue a number of health benefits, including improving skin tone, digestion, cognitive functions – and libido. The story goes that a Chinese goatherd discovered the plant’s function over 2,000 years ago when he noticed that his flock was more, erm, in the mood after eating it. Choose a testosterone booster with natural herbs that are proven to trigger your manliness. On the other hand, depression, anxieties, stress, relationship problems, and other mental health concerns can also interfere with sexual feelings. Erectile dysfunction, also known as impotence, is defined by difficulty getting and keeping an erection. In Canada, a country where wellness and vitality are valued, the demand for natural male enhancement products like Power Drops Male Enhancement has risen. Power Drops Male Enhancement is one such product that has been touted for its potential to improve male sexual performance. Among these, male enhancement supplements have gained substantial attention. Similarly, patients taking centrally acting medications such as antidepressants or antipsychotics should avoid using such products which may cause unwanted herb-drug interactions and hence side effects, one of which may be sexual dysfunction. Waynberg reported in 1994 that 60% of men with low libido have reported increased sexual desire and 50% of men with poor erection have reported improved erectile function following Muira puama administration . Although icariin has been shown to be efficacious in treatment of erectile dysfunction in aged , diabetic , and castrated animal models, it has not been tested in any randomised clinical trial. An overview of systematic reviews on various complementary medicine products for sexual dysfunction in elderly patients has found that the evidence for maca was insufficient . A further trial assessed the effects of maca in patients with erectile dysfunction using the International Index of Erectile Function Questionnaire and showed significant effects . All three studies compared the outcome values with the baseline of the same patients. Sperm motility was increased from 33.0 ± 13.5% to 42.6 ± 15.6%, and seminal RANTES, TNF-α, and IL-6 were slightly decreased. The third study was also an experimental (single-case) study (Akashi et al., 2008). Sperm count was increased from 28 ± 31 × 106/ml to 42 ± 32 × 106/ml. Madan et al. studied the effects of saffron stigma extract and two active constituents, crocin and safranal, on sexual behaviors in male rats.39,40 They concluded that the roots of CB can be useful for the treatment of certain forms of sexual inadequacies, such as premature ejaculation and oligospermia. An estimated million men suffer from some degree of sexual dysfunction. The hunt for natural supplement from medicinal plants is being intensified mainly because of its fewer side effects. A comprehensive systematic review and meta-analysis of 24 randomized controlled trials revealed significant improvements in erectile function with specific herbal treatments. Modern scientific research has increasingly validated the effectiveness of certain herbal remedies in supporting male sexual function. In fact, a comprehensive review of 24 clinical trials found significant improvements in erectile function with certain herbal treatments, involving over 2,000 participants. Researchers have studied a variety of herbal remedies for ED, but the amount of research on each herb has been small, and much of the research has been done in animals rather than people. Conventional treatments are available that may help you. If you’re one of them, you should discuss the situation with your health care provider. The authors acknowledge Leading Edge Herbals for funding the trial medications and other requisites for the conduct and publication of the study, including the article processing charges. Although Ginkgo extracts have been suggested for the treatment of female sexual arousal disorders , no placebo controlled randomised trial has been reported. Ginkgo extracts have been tested as a treatment for antidepressant-induced sexual dysfunction, which is a common side effect in depressive disorder therapy, especially when using selective serotonin reuptake inhibitors (SSRIs). Zheng et al. reported increased sexual behaviour in male rats and mice and decreased latency to erection in testes-removed rats following oral administration of lipid extracts of maca roots . It is difficult to determine the true frequency of side effects from herbs and herbal products, since surveillance systems are much less extensive than those in place for pharmaceutical drugs. Since herbal supplements are plant products, they are generally perceived and hence marketed as natural and, therefore, “safe” . Chinese Herbal Medicine Offers Hope for Treating Male Sexual Dysfunction In March 2020, Srivatsav et al. reviewed the efficacy and the safety profile of several common aphrodisiacs used in the treatment of erectile dysfunction, but the study was not exhaustive and psychiatric and neurological adverse effects were not addressed . All studies (except one) confirmed the beneficial effects of medicinal plants on the improvement of sperm and reproductive parameters and thus male infertility. These studies compared the effects of eleven different medicinal plants, i.e. ginseng, saffron, Nigella sativa, palm pollen, ADOFON, TOPALAF, sesame, and Mucuna pruriens, on male fertility with those of placebo. 2. Maca The randomization sequence was generated manually, in blocks of four, by drawing chits of paper from a bag, by a person not involved in the execution of the study or the analysis of its results. Independent quality assurance auditors verified the quality of the data generated from the study. The study was conducted at outpatient clinics of participating urologists and general physicians, from May 2009 to December 2009. The resulting new formulation, named VigRX Plus (Table 1), was evaluated for its aphrodisiac properties in male albino Wistar rats. There are also risks attendant upon self-medication and unmonitored use of these products . Of these users, 68% did so without a prescription, as patients often do not realize that they are getting false and possibly dangerous products, and 60% of these users believed they received the same product as from a legitimate pharmacy (13). Increasing household income and availability of a sexual partner positively correlate with their legal use (15). In two large surveys, 23–32% of PDE-5i users had no prior interactions with healthcare professionals (13,14). Before entering the study, the two groups were compared via Chi-Square test in terms of available demographic information including education level and age. In this regard, participants who did not receive HBS/placebo for up to 3 weeks were excluded from the study. They were advised to consume HBS/placebo 7–12 h before sexual intercourse. After face-to-face interview and evaluating eligibility of the volunteers for participation in the study and presenting complementary explanations by the interviewer, the participants were asked to sign the consent form and complete the Arizona Sexual Experience Scale (ASEX). He was found unresponsive in his apartment by his home health aide; he had saliva drooling from the mouth, and was unresponsive to questioning from the admitting physician.Testosterone levels will naturally decrease as the body ages.In this investigation, healthy male albino rats were fed with C.The plant powder showed potential activity in a human clinical trial for treatment of erectile dysfunction in males .L‑citrulline, another amino acid, is converted to L‑arginine in the kidneys, potentially providing a more sustained rise in plasma arginine levels.A systematic review of ginseng studies reinforces that supplements are most beneficial when combined with healthy lifestyle practices.The possibility of reproductive toxicity due to heavy metal contamination (Cr, As, Co, Hg, Cd, and Pb) of herbal products commonly used to boost libido or treat erectile dysfunction necessitated this study.Chronic alcohol abuse and cigarette smoking also adversely affect sexual potency. Additionally, at study end, investigators rated response to therapy as excellent, good, fair or poor. Safety was evaluated through incidence of adverse events, changes in laboratory parameters and subject’s rating for tolerability of treatment. Prior use of conventional or alternative medicine required a wash out of 7 and 15 days respectively. Both active and placebo were packed in identical containers with identical labels carrying patient ID and treatment week as distinctive markers for dispensing and monitoring compliance. The study medications were indistinguishable in terms of appearance, weight and taste. They discovered several that improved male sexual function. Erectile dysfunction (ED) is the inability to get and/or keep an erection that’s firm enough to have sexual intercourse. If you're interested in making your breasts larger, talk to your healthcare professional about more-effective options, such as breast implants. EF, Erectile function; IS, Intercourse satisfaction; OF, Orgasmic function; OSD, Overall satisfaction; SD, Sexual desire. The study has set grounds for further evaluation of VXP in patients with well-recognized risk factors and distinctly identified forms of ED. Differences in color or size of pills can serve as cues in differentiating the active treatment from placebo to introduce a response bias. Patient expectations could also be influenced by foreknowledge of the treatment assignment. In clinical trials of drug treatments, placebo responses have often been substantial, usually significantly and statistically better than no treatment (baseline). Maca Root (Lepidium Meyenii) Psychiatric and neurological side effects included headaches and hypnotic effects and were mild. There were no reports on the side effects of damania (T. diffusa), the Mexican poppy (A. mexicana), and Tongkat Ali (E. longifolia). Few clinical reports and few data were found for the side effects of bitter orange (C. aurantium), muirapuama (P. olacoides), and kanna (S. tortuosum), and only preclinical reports were found for muirapuama. Kratom (M. speciosa) and yohimbe presented the highest rate of side effects, but yohimbe’s general toxicity is mainly cardiovascular, due to its effects on the NO pathway. Based on the available literature, some of these plants increase sperm count and motility while a number of others alter the secretion of hormones by the testicles (11). Such a growing interest in medicinal plants has inspired scientists to clarify their effects on male fertility. The European Association of Urology has recently reported the use of complementary treatments based on traditional medicine as a multidimensional integrative approach to male infertility treatment (9). Men searching for natural ways to enhance sexual wellness are turning to powerful herbal remedies instead of pharmaceuticals.Another clinical study of 65 infertile men who received 250 mg of Tribulus extract daily reported significant improvements in sperm concentration and motility.The fresh root of ginseng can be directly chewed after peeling or soaked in wine for drinking and chewing.It is reported that nearly 100 million people around the world are living with erectile dysfunction.Consequently, the use of herbal supplements to enhance sexual drive has become increasingly popular, and more than 300,000 intoxications were reported to poison control centers over the last 20 years 6,7.Kanna, or Channa, is the traditional name of a succulent, perennial plant belonging to the Aizoaceae family (earlier Mesembrynantheaceae) that is indigenous to South Africa, where it is consumed by local tribes to relieve thirst and hunger and combat fatigue 264,265.Therefore, there appears to be a lot of cross talk at different neuronal levels between dopamine and nitric oxide; this has been discussed further in the next section.Our understanding of the process and initiation of sexual arousal is finding a more lucid basis, which stems from evidences in both preclinical and clinical studies.We are committed to maintaining the highest quality products and the utmost integrity in business practices. This trial comprised 76 males with idiopathic infertility, which was randomized into a treatment group and a placebo group. Officinarum, a Chinese herbal medicine belonging to the Zingiberaceae family, was studied in Iran through a double-blind RCT (Kolangi et al., 2019). Also, sperm motility was increased from 32 ± 17% to 39 ± 19%, and a significant increase in seminal plasma soluble Fas (sFas) was observed. A significant increase in sperm motility and sperm density was noticed. An increase in the sperm concentration was detected, and 25% of couples achieved pregnancy. Zinc is one of the only supplements that I always have with me, especially while traveling. In one study (animal), the mice engaged in more rounds of sex for longer durations each round. I think of astragalus as the vitamin C of Chinese herbs. Unlike cordyceps, astragalus is better to take daily to get the most health benefits. Drugs affecting the brain and presumably sex centers are generally attributed with an increase or decrease in sexual arousal. Our understanding of the process and initiation of sexual arousal is finding a more lucid basis, which stems from evidences in both preclinical and clinical studies. Having discussed the Ayurvedic basis for the role of Vajikarana herbs, it is important to understand the role of modern pharmacology and an insight into the control of the sexual behavior in the human body. This was the same therapy received by the treatment group with the difference being the addition of the Gushenyutai plaster which contains 23 herbs. According to the review, the combination of clomiphene, zinc, and testosterone, as well as CoQ10, FSH, and tamoxifen yielded the best improvements in male semen parameters (Shahid et al., 2021). Three studies (Yu et al., 2017; Nasimi Doost Azgomi et al., 2018; Aghajani et al., 2021) compared the efficacy of herbal intervention with pharmacological (pentoxifylline) or supplement-based (vitamin C, vitamin E, and glutathione) intervention. Collectively, a decreased concentration of aforementioned chemokines except for sFas (it should be increased) may lead to improvement in male infertility. The results also showed that the decoction could have a dual-directional regulatory effect on the levels of follicle-stimulating hormone, luteinizing hormone, testosterone, and cortisol. Regulatory agencies emphasizing the impact of the usage of these supplements on the health of general public and striving to impose strict regulations on these products. It was concluded by the psychiatric treatment team that the patient’s physical state/seizures like activity was resulting from his continued misuse of over-the counter- ED supplements as self-reported by patient and his friend. The FDA has identified more than 350 different supplements marketed for sexual enhancement and found to be tainted with prescription medication of which the quality and quantity is questionable due to lack of oversight in these products. Nevertheless, the use of herbal medicines continues to expand rapidly across world and many people perceive usage of herbal medication as a safe and reliable way to improve health outcome. The commonly reported cosolvents were “tella (local drink)” (8 species), butter, honey (5 species), and coffee (4 species). In agreement with this study, Semenya and Potgieter mentioned the oral route as the dominant route for ED. Irrespective of the dominancy, however, confirming the pharmacological activity of the claimed plant part is necessary, because most plant parts reside several bioactive principles. Subacute oral administration of hexanic Maca extract improved sexual performance parameters in sexually inexperienced male rats most effectively . Longifolia produced a dose-dependent, recurrent, and significant increase in the episodes of penile reflexes as evidenced by increases in quick flips, long flips, and erections of the treated male rats during the 30-min observation period . An electric grid was used as an obstruction in the electrical copulation cage in order to determine how much an aversive stimulus the sexually naive male rat for both the treated with E. The extract increases sperm count significantly 44, 52. An increase in mount frequency and attractability towards female was observed . This is due to the reduction of the hesitation time of the sexually inexperienced males towards receptive females as indicated by the significant decrease in the ML. Whitei showed sexual enhancement in sexually inexperienced male rats. It is used to increase libido and also for the management of low sperm count. On day 60 the sperm count increased significantly in both the CB groups, 125 mg/kg and 250 mg/kg, in a dose dependent manner. The observed effects appear to be attributable to the testosterone like effects of the extracts. Yohimbine and related alkaloids also inhibit monoamine oxidase,14 which causes serotonin and epinephrine to increase in the brain. Being a crucifer, maca roots and commercial maca products (eg, powders, tinctures, encapsulations) contain glucosinolates that may help optimize metabolism of hormones and protect hormone-sensitive tissues from carcinogens. Early herb texts claimed Lepidium to be specific for breast pain when the pain was squeezing or lancinating in quality; these texts also reported maca as helpful for menorrhagia. Traditionally, dried maca tubers are cooked in soups or are ground into a flour and used in a variety of baked goods; the herb is believed to improve energy and stamina, fertility, heart function, mood, and longevity. The authors would like to acknowledge the Shahrekord University of Medical Sciences, Shahrekord, Iran, for supporting this study. None of signs of sperm anomalies and testicular damages were observed . A list of few of the various popular herbs with ehtnopharmacological backing for being used as aphrodisiac. This mechanism may constitute one way in which androgens stimulate sexual arousal . NO is synthesized by the enzyme nitric oxide synthase (NOS) which plays an important role in many brain functions. It is hence essential to evaluate the effects of biologically active herbal compounds on male fertility and to identify natural compounds with estrogenic and anti-estrogenic properties(5). The World Health Organization (WHO) encourages the use of medicinal plants, and suggested researchers to define the rational use of medicinal plants as a source of new treatments (10). Complementary therapies for infertility have received growing attention during recent years and various antioxidants, nutritional approaches, and medicinal plants have been proposed for the treatment of fertility problems in infertile and sub fertile couples (6). What are the most common ingredients in these supplements? While some ingredients have shown promise in small studies, the evidence for many is inconclusive. The effectiveness of over-the-counter male enhancement pills is a subject of ongoing debate and research. It is always best to consult with a healthcare professional before taking any new supplement. Superba alcoholic extract (0.01, 0.1 or 1.0 mg/kg BW/day) for 6 months treatment significantly increased the sperm concentration and delayed the decreased motility with time. Many researchers have investigated the active bioconstituent present in different herbs that are responsible for enhancing sexual activity, spermatogenesis and showing other positive effect in reproductive parameters (Table 3). Interestingly, administration of testosterone to castrated male rats increases the number of NO synthase-labelled neurons in the mPOA, indicating an increase in NO synthesis . After that, the selected studies were considered high quality with a score above 3 out of 5. Unpublished documents, review studies, conference abstracts, theses, book chapters, comments, and response articles were excluded. Further details about study eligibility and the selection process are shown in Table 2 (PICOS framework) and in the PRISMA flowchart diagram (Figure 1). The study design employed PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) . Apart from traditional hormone replacement therapy in men , many non-pharmacological strategies have emerged in an attempt to mitigate androgen deficiency, with no discernable effects documented to draw solid clinical recommendations 5,6. Over the years, Enzyte has become a recognizable name in the male enhancement category because of its focus on natural ingredients, easy daily use, and a holistic approach to men’s vitality.Modern life brings stress, long working hours, unhealthy food habits, lack of physical activity, and mental pressure. Erectile dysfunction can result from a problem with any of these. Your main healthcare professional is a good place to start when you have erectile issues. Erectile dysfunction symptoms are ongoing and often get worse over time. A combination of data from non-English literature might alter the significance of the current analysis of various male infertility interventions. Due to a lack of resources, non-English studies were not reviewed as it was difficult to translate them to other languages. Caution must be exercised, however, in the use of herbs at least until the FDA and WHO approve them. However, it is really difficult to recommend herbal interventions as alternative to pharmacological interventions as it is hard to come to a conclusion about which one is most effective among those. Most of the studies included in this review have shown positive trends in the semen parameters and thus present a strong case of having comparable efficacy and possibly being an alternative to pharmacological interventions in the future. Some Chinese herbs ameliorate ED through one pathway, others involve several pathways (Table 1). Most of the herbal remedies are used empirically and thereby are not convincing. A great number of traditional Chinese herbs have been used to treat ED, applied singly or in the form of compound formulas. Thereby, the available evidence at present is insufficient to prove acupuncture to be an effective intervention for ED treatment (9,10). A total of 68.4% patients in the treatment group showed a satisfactory response, which was significantly higher than the placebo group (6). In both groups, attempts to intercourse ranged from 3–4 or5-6 in the four weeks prior to entering the study. While all men receiving VXP completed the study duration of 12 weeks, one in the placebo group was withdrawn due to his unwillingness to continue participation, and two others were lost to follow-up (Table 1). Data on EDITS (patient and partner versions), seminal parameters and serum testosterone were analyzed by independent sample t test. Mean changes in IIEF-EF, IS,OF,SD and OS domains, and total IIEF scores from baseline to end of treatment were evaluated by analysis of covariance (ANCOVA) with baseline scores as the covariate. It is essential to speak with a doctor or pharmacist before taking any male enhancement supplement, especially if you are taking other medications. However, unauthorized products are still found on the market. Yes, in Canada, over-the-counter male enhancement pills are regulated as Natural Health Products (NHPs). Administration of Hochu-ekki-to and Withania somnifera resulted in an improvement in sperm motility and concentration and a decrease in cytokines and an improvement in the primary endpoints of semen, respectively. The most number of studies three were conducted on Hochu-ekki-to, followed by two on Withania somnifera. A total of 83 out of 87 (95.4%) spermatopathy patients were treated with the decoction, and 49 out of 87 patients were successful in getting their spouses pregnant. Also, the active ingredients of these herbs plus their chemical and molecular formula are listed in Table 2. However, there has been a great deal of interest in finding natural antioxidants from herbal materials to replace synthetic drugs recently (Hasani-Ranjbar et al., 2009). Oxidative stress appears to be due to increased ROS production rather than a decrease in antioxidants (Safarnavadeh & Rastegarpanah, 2011). The male and female reproductive organs are rich in both enzymatic and non-enzymatic antioxidants. With its anti-oxidant properties, L-arginine can be an integral part of any sexual wellness supplement. Side effects include nervousness, anxiety, insomnia, and possibly mild hypertension (5). Rich in sterols e.g., sitosterol, campesterol and lupol it activates the body’s receptors for hormones like testosterone to heighten libido and enhance performance (5). It acts as a nerve stimulant to heighten receptiveness to sexual stimuli as well as physical sensation of sex (9). Benefits are felt gradually over a period of time, mainly because it enhances the natural biological synthesis of testosterone. The people of Ethiopia depend heavily on medicinal plants to ease their ailments, including erectile dysfunction. Further searches for global reports indicated that Zingiber officinale is the only plant encountered in this study that have been subjected to clinical studies investigating its effect on male ED, female sexual function, and infertility . Other reports were for ethanolic stem bark extract of Ekebergia capensis which alleviated sexual dysfunction by increasing the mounting frequency and testosterone levels of male rats to 2.38 ± 0.02 ng/ml, 7.68 ± 0.66, and 14.5 ± 0.777 ng/mL at doses of 300, 400, and 500 mg/kg, respectively . Methods of preparation of herbal remedies used in the treatment of erectile dysfunction and infertility, and enhancing fertility and virility in the EAC. Animal studies have demonstrated that cynomorium can enhance blood plasma testosterone levels, promote sexual maturity, and increase sexual behavior in young male rats. It is a rich source for the amino acid taurine, which is used for cardiac health and nerve transmission. This is used in some Asian remedies for sexual weakness and lowered libido. Clinically its effects have been proved with experimental animals (5,15). The traditional herb with aphrodisiac properties is used as a medicine to treat a variety of conditions including infertility, ED, and testosterone decline. Bulbine is proven to increase the testosterone level in the testes and blood, increase the size of the testes, and improve the quality of testicular enzymes. When talking about African herbs that boost testosterone, it would be a sin to not mention bulbine natalensis. Tortuosum has been marketed for the treatment of mild depression and to improve mood . In addition, mesembrine is also an agonist of GABAA, δ2-opioid, μ-opioid, cholecystokinin-1, E4-prostaglandin, and melatonin-1 receptors at high doses, and shows antinociceptive effects in animal models 266,270,271,272,273. Kanna alkaloids inhibit serotonin reuptake and PDE4A, potentially enhancing sexual potency and libido 267,268,269. Kanna’s main active compounds are mesembrine, mesembrenol, mesembrenol, and mesembrenone, which are synthesized in the plant through the condensation of phenylalanine and tyrosine amino acids. The dried aerial parts of the plant are commonly chewed or consumed as teas, decoctions, and tinctures and sometimes smoked or snuffed . Rejuvaknee Massager It is important to approach any male enhancement product with realistic expectations. Heater By supporting the body’s natural processes, it may help improve confidence and overall satisfaction when combined with a healthy lifestyle. Unlike products that rely on harsh stimulants, GaraHerb is positioned as a gentler option for men looking to enhance their daily vitality. Related Articles Of the two, a similar study in 60 patients with mild to moderate ED showed an increase in the IIEF-five item scores from a baseline of 16.4 ± 2.9 to 21.0 ± 6.3, after receiving 1000 mg (3 times daily) of ginseng for 12 weeks . Among the herbal constituents of VXP, only Korean red ginseng has been previously evaluated on the IIEF scale, in two double-blind, randomized, controlled studies. Practitioners of traditional medicine believe that combinations of herbs improve efficacy and reduce adverse effects . The present study evaluated VigRX Plus, a poly-herbal supplement purported to offer natural sexual enhancement in men. Over recent years, the use of complementary and alternative medicines has become increasingly popular , and ED is one condition for which herbal supplements are heavily promoted and easily accessible . The goals of medicines, whether allopathic, traditional or complementary, are thesame, namely, to benefit patients therapeutically and improve their quality of life.Based on these assumptions, one can look forward to a near future of integratedorthodox and traditional medicines, and hope that experimental and clinical researchin traditional, complementary and alternative medicines will help to developaffordable, safe and effective natural medicines for erectile dysfunction, ratherthan criticising and marginalising unorthodox medicines, ethnomedical claims andtraditional findings. There is a dire need to develop some of the existing potent, African traditionalremedies for erectile dysfunction into scientifically acceptable natural medicines.With the financial and goodwill support of governments, non-governmentalorganisations and philanthropic individuals, coupled with the cooperation ofmultinational pharmaceutical companies such as Pfizer and others, it should bepossible to develop some of the currently available African traditional remedies forED into acceptable, potent natural medicines in the foreseeable future. For example, the Zulu peopleof South Africa have, for centuries, used the roots of Eriosema species as a remedyfor the treatment of erectile dysfunction and/or impotence. However, theaetiology of erectile dysfunction has been shown to have a significant impact ontreatment success and satisfaction rates, with neurogenic causes of erectiledysfunction (eg, diabetes mellitus and prostate surgery) having significantly lowertreatment success rates than psychogenic or vasculogenic erectile dysfunction.15 Clinically known aetiologies of ED include organic, psychogenic and combinedorigins.1 Cardiovascular disorders anddiabetes mellitus are known to contribute significantly to erectile dysfunction oforganic origin.6,8 Organic causes of erectile dysfunction are found in 80–90% of ED patients,and these include vasculogenic (ie, arterial, cavernosal and mixed), neurogenic,anatomical and endocrine causes.4 Psychogenic forms of ED are usually due to sexualperformance anxiety, depression and inhibited sexual drive.4 Panax, which is widely used by herbalists as an adrenal tonic, may also improve low sperm counts and low testosterone levels in men. Panax ginseng (ginseng) is one of the best-known sexual and reproductive herbs, used for centuries as an anti-aging and longevity tonic; the roots are purported to help maintain sexual function into old age. Low testosterone levels are frequently demonstrated with modern lab testing, especially in the elder decades of a man’s life, and many symptoms – including low libido, loss of muscle mass, poor stamina, and infertility – have been treated with herbal medicines since ancient times. Health food stores often have an entire section of products dedicated to enhancing the libido, improving erectile function, and boosting low testosterone, sometimes located right next to the pills that help you gain muscle mass and “burn” fat. It is essential to consult with a healthcare professional before incorporating herbal remedies into your regimen. Men interested in a comprehensive approach to sexual wellness can explore our detailed guide on natural male enhancement for more personalized strategies. Research on L-Arginine demonstrates how specific amino acids can support nitric oxide production, essential for improving blood flow and sexual function. Among the great attributes of this herb is its antioxidant property which helps in combating oxidative stress by lowering cortisol levels. Ashwagandha has so many proven health benefits. Are you searching for natural strategies to augment male fertility? Because interactions are not fully studied, it is advisable to discuss any combination therapy with a healthcare provider before use. No significant difference was observed in the tolerability of treatment as a majority of subjects in both groups (31 in VXP and 28 in placebo) rated the tolerability as very good. A single serious adverse event occurred in this study when one subject from VXP group was hospitalized due to malarial infestation and subsequently withdrawn from the study. More patients in the VXP than in the placebo group were very satisfied with their overall sex life sexual relationship with their partner. Another formulation was adulterated with phentolamine, a drug that is not approved for boosting male sexual performance when taken orally. Nevertheless, further in-depth studies are required to elucidate such effects. This suggests that antioxidants have been to improve spermatogenesis of male reproduction system. Decrease in hormone level with age, systemic diseases like cancer also influences sexual ability. Chronic alcohol abuse and cigarette smoking also adversely affect sexual potency. ED is defined as the consistent inability to obtain or maintain an erection for satisfactory sexual relations. For individuals seeking to improve their stamina and sexual endurance, incorporating Mulondo preparations into their wellness routine may prove beneficial. Mondia whitei, the plant from which Mulondo Roots are derived, contains an array of essential nutrients that contribute to its potency. Studies suggest that Mulondo Roots may offer promising benefits for both libido and erectile quality. On the other hand, the relatively frequent use of leaves could be related to their availability and the fact that they are the photosynthetic sheet of plants that accumulate therapeutic phytochemicals . Figure 4 illustrates which plant organs are widely used in preparation of the herbal remedies, that is, roots (44.9%), leaves (21.8%), and stem and root barks (16.7%). Synopsis of the most used plant species for the treatment of infertility among men and women in the East African Community. In regards to the treatment of infertility, most plan species recorded were indicated to be used for the treatment of female infertility (Table 2). The commonly mentioned plants were Mondia whitei (12 times), Warburgia ugandensis (4 times), Acalypha villicaulis, Combretum illairii, Erythrina abyssinica, Pappea capensis, and Rhus vulgaris (3 times each). Kanna, or Channa, is the traditional name of a succulent, perennial plant belonging to the Aizoaceae family (earlier Mesembrynantheaceae) that is indigenous to South Africa, where it is consumed by local tribes to relieve thirst and hunger and combat fatigue 264,265. In addition, higher doses, either acutely or subchronically (15 days), did not cause a worsening of adverse effects . Data showed that the maximal effect was reached 6 h after administration of a low dose of muirapuama extract and produces significant and long-lasting (up 12 h) effects in both chemical and thermal tests of nociception in mice. The researchers also noted that gonadotropic hormones levels (LH and FSH) were well maintained in the shilajit group. It should be mentioned that tongkat ali did not affect luteinizing and follicle-stimulating hormones during this study. In another randomized, double-blind, placebo-controlled study, 105 men aged between 50 and 70 were given either a placebo or standardized tongkat ali extract for 12 weeks. In a 12-week, randomized, double-blind, placebo-controlled study, 109 men between the ages of 30 and 55 were either treated with 300mg of tongkat ali extract or a placebo. Therefore, in order to develop a novel approach to the treatment of male infertility, further clinical trials are warranted to determine the maximum dosage and duration of treatment with herbal medicines and evaluate any potential side effects of such interventions. These seeds are incredible natural male enhancement that offer a cure for erectile dysfunction. Any plant that has the ability to cure erectile dysfunction is definitely a plant worth researching. Ethanolic extract of roots as well as sapogenins isolated from the roots were studied for effect on sexual behavior and spermatogenesis in albino rats. Serum testosterone and FSH levels were lower in animals treated with extracts than controls, whereas interstial cell stimulating hormone levels was higher in treated animals . Aqueous extract of the plant elicited notable spermatogenesis in immature rats. Testicular histology showed increased spermatogenesis and seminiferous tubules full of sperm in the treated group compared to the untreated controls . Aqueous extract of Cynomorium coccineum induced significant increase in the sperm count, improved the percentage of live sperm and their motility, and decreased the number of abnormal sperm. Anxiolytic effects have been demonstrated in modern research.19 In keeping with folkloric tradition, Turnera may improve sexual function and libido when suppressed by stress and anxiety, and help improve the mood in cases of nervous debility. Although the aphrodisiac claims may be exaggerated and with sparse corroborating scientific research, the plant has been shown in aging rats to increase sexual activity.18 Turnera has been traditionally used to treat menstrual and pregnancy disorders, incontinence in the elderly, fatigue, and anxiety. Maca’s antioxidant and anti-inflammatory properties, as well as circulatory effects via nitric oxide production, make it a promising cardiovascular agent.7-10 The herb has also been shown to increase sperm count and motility.11 Losing weight, reducing stress and a healthy lifestyle have all been shown to increase testosterone levels in men, Dr. Simone says. Drewes et al.20,21 have shown, in a rabbitexperimental model, the plausible therapeutic beneficial effects of bioactivecompounds of E kraussianum in the management of erectiledysfunction. It has been suggested that for maximum benefit, milk infusions and decoctions ofEriosema kraussianum roots are to be taken two to four hoursbefore any anticipated sexual intercourse, and the effects (achievement andmaintenance of penile erection sufficient for satisfactory sexual intercourse afterpenetration) of the plant extracts have been reported to last for four to six hoursfollowing oral dosing of the milk infusion or decoction of the rootstock extracts(Drewes, pers commun). Thousands of African medicinal plants (belonging to several genera and families, andwith diverse chemical constituents) have been reported to possess aphrodisiac andsexual stimulant properties (Koloko, pers commun). The various communities and societies on the continent, in addition to‘owning’ traditional remedies for ailments such as hypertension, diabetes mellitus,arthritis and other chronic conditions, also ‘own’ remedies for socio-culturaldiseases such as erectile dysfunction. For older men, underlying health conditions such as cardiovascular disease or diabetes are more likely to be a contributing factor to erectile dysfunction. The best way to prevent erectile dysfunction is to make healthy lifestyle choices and to manage any health conditions. Also, stress and mental health concerns can cause erectile dysfunction or make it worse. If you're worried about erectile dysfunction, talk to your healthcare professional, even if it's awkward. It also showed antifertility activity in male rat . The ability of tribulus to increase the release of nitric oxide may account for its claims as an aphrodisiac 100, 102. Terrestris also increased the synthesis of cyclic nucleotides in CCSM cells . Androgens are known to increase both androgen receptor and NADPH-d positive neurons either directly or by its conversion to oestrogen. As mentioned above, one case has been reported with hypomanic symptoms combined with tachyarrhythmia . The man improved after three days as an inpatient, with the suspension of the herbal supplement . No long-term toxicity study has been conducted using horny goat weed (or icariin) in any animal species. Because of these potential mutagenic properties of MTCA, the French Agency for Sanitary Security warned consumers of powdered maca root about possible health risks from its ingestion . Lee et al. have reviewed the literature to determine maca's possible effects on menopausal symptoms and confirmed the inadequacy of the present data to clearly state efficacy and safety . The results of these herbs on fertility depend on the type of herb, consistency, and health conditions. Since, treatment procedures change from person to person, it is always best to consult with a doctor before combining these herbs with other fertility treatments. These assisted reproductive technologies are designed to address underlying issues that herbs alone may not resolve — such as low sperm motility, poor morphology, or unexplained infertility. Importantly, these changes happened without altering hormone levels such as testosterone or estrogen, suggesting that maca works directly on sperm quality rather than through hormone changes. Another clinical study of 65 infertile men who received 250 mg of Tribulus extract daily reported significant improvements in sperm concentration and motility. Shilajit may also support male reproductive health through synergistic effects with CoQ10, a molecule essential for mitochondrial energy production and a powerful antioxidant. In one small study, 28 men took Shilajit for 90 days and experienced a 61% increase in sperm count along with a 12–17% improvement in sperm motility. Contrary to the general belief, recent reports have questioned the safety of some herbs including Ginkgo biloba which has concerns over blood-thinning effects and ocular toxicity . Icariin, the active ingredient from Epimedium sagitattum, improved the erectile function and expression of nitric oxide synthase in castrated rats 30,31. The efficacy results of this first-in-human study were generally consistent with the effects demonstrated by VXP in animal experiments. The USA FDA approved yohimbe as the first plant derived drug for treating impotency long ago and was dubbed the herbal viagra II in the February 1999 edition of Environmental Nutrition. It has also been shown to increase sperm concentration and motility and increases energy in the individual by enhancing ATP production by 60% thru oxidative phosphorylation. Early reference to its medicinal use was in 2900 BC Chinese Materia medica which believed it increased sexual energy. It increases blood circulation which better prepares the male for the heart-racing excitement of sex.