In Indonesia, 100% of “Viagra” sold by street peddlers, 56% purchased in “drug stores”, and 13% acquired from legitimate pharmacies was counterfeit Viagra marked as authentic (29). Similar results were found in an analysis of counterfeit ED drugs sold in Italy, Austria, and Canada (28). In 2009, United Kingdom authorities seized 2,383 samples of counterfeit Viagra and forwarded them to Pfizer laboratories for analysis. The most detrimental problem with counterfeit PDE-5i is that the content is unregulated. Do Honey Packs Provide Benefits? Since herbal supplements are plant products, they are generally perceived and hence marketed as natural and, therefore, “safe” . The effects of the aforementioned products, thus, remain unknown until reports on harms expose the problem and accurate clinical evaluation takes place. These products are advertised on the Internet as “natural” and “safer” alternatives to pharmaceutical products, such as gold standard for treatment of erectile dysfunction and the phosphodiesterase type 5 (PDE5) inhibitors (e.g., sildenafil, tadalafil, and vardenafil). The possible impact on population health, particularly among subjects with psychiatric disorders, usually at risk for sexual dysfunction, may be significant. This phenomenon, combined with the availability of these products over the Internet, represents a challenge from a clinical and a public health perspective. If you or your child is otherwise healthy, there's usually no reason to try to stop occasional coughing. Due to the risk of infant botulism — a rare but serious form of food poisoning — never give honey to a child younger than age 1. The honey can be given as is or added to other liquids, such as juice, to lessen its strength. Children ages 1 and older can be given 0.5 to 1 teaspoon (2.5 to 5 milliliters) of honey to treat a cough. A summary of the research studies conducted on honey and its reported effects on serum and urinary levels of testosterone. For example, it was shown that male albino Wistar rats orally supplemented with caffeic acid at 50 mg kg−1 had higher serum levels of testosterone and luteinizing hormone compared with the control . Similarly, patients taking centrally acting medications such as antidepressants or antipsychotics should avoid using such products which may cause unwanted herb-drug interactions and hence side effects, one of which may be sexual dysfunction. It is therefore essential that patients with sexual dysfunction either of psychogenic or organic aetiology should avoid taking such herbal products which may have adverse effects on their mental state. The Second Princeton Consensus on sexual dysfunction and cardiac risk stated that all men with ED, even in the absence of manifesting cardiac symptoms should be regarded as having potential risks for cardiovascular disease (24). This communication reviews the literature regarding counterfeit PDE-5i, and summarizes both the scope and dangers of the illicit PDE-5i market. However, taking illicit PDE-5i may harm consumers directly, as many illicit products contain detrimental contaminants and inaccurate amounts of the active ingredient without the appropriate warnings. Hone-affiliated medical practices are independently owned and operated by licensed physicians who provide services using the Hone telehealth platform. This ingredient also lowers cholesterol levels and blood sugar. In addition, it treats erectile dysfunction in men. This component helps in boosting energy levels in the body. Nitric acid is also responsible for penile erections.Research-backed tools, tactics, and techniques to maximize your health, delivered to your inbox every Monday.There's currently no evidence to show how honey might interact with other drugs.FDA laboratory analysis confirmed that Royal Honey VIP contains tadalafil, the active ingredient in Cialis, an FDA-approved prescription drug for erectile dysfunction.Austin Letorney is a writer who covers health, entertainment, lifestyle, and fitness.Maca extracts have been shown to contain benzyl glucosinolates and polyphenols, (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA), and p-methoxybenzyl isothiocyanate among many other chemicals .Too expensive compared to related supplements in the market.Quantities of active ingredients are also highly variable, as seen in Table 2. Many of these side effects occur because there is cross-reaction with other phosphodiesterase types located throughout the body (18,22). Other side effects include headache, dyspepsia, flushing, myalgia/back pain, visual disturbances, and nasal congestion. There are numerous known side effects of PDE-5i, some of which may be life threatening. Although icariin has been shown to be efficacious in treatment of erectile dysfunction in aged , diabetic , and castrated animal models, it has not been tested in any randomised clinical trial. Because of these potential mutagenic properties of MTCA, the French Agency for Sanitary Security warned consumers of powdered maca root about possible health risks from its ingestion . Piacente et al. (2002) have shown the existence of 1R,3S-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA) in the extracts of maca. Lee et al. have reviewed the literature to determine maca's possible effects on menopausal symptoms and confirmed the inadequacy of the present data to clearly state efficacy and safety . Since honey is safe for people over age 1 year, it might be worth a try. The honey seemed to lessen their coughing and help them sleep better. But honey alone may work as well as medicines available without a prescription to lessen coughing. Drinking tea or warm lemon water mixed with honey is often used to soothe a sore throat. If you are a Mayo Clinic patient, we will only use your protected health information as outlined in our Notice of Privacy Practices. Erectile dysfunction (ED) is a common problem and increases in incidence as men age (10). Many factors contribute to the disproportionately large market of counterfeit PDE-5i. Globally, antibiotics comprise the largest class of counterfeit medications, but in Europe, PDE-5i are the most commonly counterfeited medicines (7). However, even in these well-regulated countries, the market for counterfeit PDE-5i has grown. The large market for counterfeit medications is not equally distributed in size or class of medications worldwide. In one study, the ingredients of 58 products available for the treatment of ED without a prescription were analyzed. There is also an indirect risk of missing potential medical conditions in patients that bypass the healthcare system to purchase illicit PDE-5i. The ease and convenience of purchasing counterfeit PDE-5i products via the Internet have contributed to the growth of the illicit market. Table 1 demonstrates the direct research studies conducted on honey and its reported effects on testosterone. In conclusion, the collective evidence, which is mainly based on in vivo system studies, reveals that oral administration of honey increases serum testosterone level in males. Here, we intended to systematically discuss and present the impact of honey on serum levels of testosterone in males. Some of them include boosting immunity, skin care, and energy enhancement. This formula contains mono-floral honey. Too expensive compared to related supplements in the market. Several Royal Honey Male Enhancement reviews are negative. The supplement is medicinal and has a natural sweetness. In addition, the supplement helps males last longer during intercourse. Ellagic acid and rosmarinic acid at 10 mg kg−1day−1 and 75 mg kg−1day−1, respectively, for 2 weeks, were found to attenuate doxorubicin-induced testicular damage in male Sprague-Dawley rats . Furthermore, quercetin at 20 mg−1 kg−1, for 4 weeks, attenuated testosterone depletion in male Wistar rats induced by cadmium compared with the control . Companies on Trustpilot aren't allowed to offer incentives or pay to hide reviews.US National Institute of Health also warns consumers about taking yohimbine supplements if they suffer from schizophrenia, anxiety, depression, or posttraumatic stress disorder .If medication is appropriate, your doctor will provide a prescription and monitor for side effects and efficacy.”Furthermore, quercetin at 20 mg−1 kg−1, for 4 weeks, attenuated testosterone depletion in male Wistar rats induced by cadmium compared with the control .In particular, such oxidative stress state, when occurs in Leydig cells in the testes, may reduce testosterone synthesis , and hence the level of serum testosterone.The agency claims that companies promoted the product as sex-enhancing drugs.Non-declared pharmaceuticals can have drug interactions and side effects such as gastrointestinal symptoms and nausea when combining metronidazole and alcohol.Regardless, it is clear that counterfeit medications have reached an industrial level scale.In general, regardless of its variety, honey is a natural product and an ancient part of humans' food .In conclusion, the collective evidence, which is mainly based on in vivo system studies, reveals that oral administration of honey increases serum testosterone level in males. Black Mamba Male Enhancement The supplement “Royal Honey for Men” claims to deliver ultimate power and is “the most potent and natural source of sexual power and testosterone,” according to their marketing. The agency found the active ingredients in Cialis and Viagra—prescription meds used to treat erectile dysfunction—in the supplements. Popular honey-based sexual supplements may not be as natural as you think. “By purchasing products like honey packs, you are potentially doing more harm to your body than good,” Dubin says. “Most of these products contain unregulated, synthetic, and potentially dangerous medications and materials.” Sealed in individual packets, they contain honey and other natural ingredients, such as black ginger extract, vitamin C, ginseng, and maca root, says Seth D. Cohen, MD, MPH, a urologist at NYU Langone in New York City. Each case includes 48 display-ready boxes, each with 12 x 15g sachets, made from a powerful blend of natural ingredients and real honey. In an analysis of 24,708 patients receiving a PDE-5i, 70% had an underlying medical diagnosis, with 50% of these patients having vasculogenic disease.Therefore, mechanistically, serum testosterone level is directly influenced by the amount of luteinizing hormone produced.In conclusion, the mechanism of action of yohimbine in enhancing sexual function is currently unclear.Some of them include boosting immunity, skin care, and energy enhancement.Besides the high profit margins, the underlying characteristics of consumers of PDE-5i make it a prime target for counterfeiters.As a result, the Department of Health opened an investigation and appealed to members of the public not to buy or consume the product .Claim a refund if your order doesn't ship, is missing, or arrives with product issuesTherefore, this ingredient helps support male vitality.Testosterone is an anabolic steroid considered as the foremost sex hormone in males 1, 2. Some people can tolerate foods with lower fructose levels if they eat them in small amounts with meals. Fructose is a sugar found naturally in fruits, fruit juices, some vegetables and honey. To make the sauce, in a small bowl add the water, brown sugar, honey and olive oil. If you have any concerns, check with your doctor or other healthcare professional for advice. Up to the present time, the majority of these studies were animal studies, in particular, in rodent studies; only two studies were conducted on human males. The studies were conducted on different honey varieties from different countries (India, Malaysia, Turkey, Iran, Nigeria, and Italy). This was conducted by searching Scopus, PubMed, and Embase electronic databases for research articles (published only in English language) from May 1993 through April 2019 using the keywords “honey” and “honeybee” versus “testosterone”. Furthermore, the color and the flavor of honey is due to presence of various organic acids such as gluconic acid, Levulinic acid, formic acid, citric acid, lactic acid, aspartic acid, fumaric acid, butyric acid, malic acid, succinic acid, and others 31, 33. Moreover, honey is rich with natural antioxidants such flavonoids and phenolic acids, which exerts a wide range of biological properties . Most online reviews show that the formula helps boost libido in men. The supplement is also instrumental in removing allergies. This component helps enhance sex drive in males. Royal Honey contains tadalafil, among other ingredients. Yohimbe, ginseng, Ginkgo biloba, maca, horny goat weed, and L-arginine were claimed to be the most common ingredients in those products. It is estimated that less than 1% of side effects or adverse events for herbal products are recorded with the current surveillance systems . It is difficult to determine the true frequency of side effects from herbs and herbal products, since surveillance systems are much less extensive than those in place for pharmaceutical drugs. The supplement has administration instructions. Therefore, women should not consume it as a supplement to enhance their sex drive. This formula only works for males. Lastly, the article showcases the available alternatives for the product. The agency said the supps contained the active ingredients in prescription ED meds. This evidence underscores the role of quercetin, and hence, albeit partially, the role of honey, in enhancing testosterone production, especially in chemical-induced reproductive toxicity conditions. Accordingly, administration of honey, as a rich source of chrysin, may enhance, albeit partially, the production of testosterone. In addition, another in-vivo system study conducted by Nasrolahi et al. concluded that administration of honey at 1.0 g kg−1 day−1, for 40 days, inhibits diabetes-induced oxidative damage in testicular tissues and increases serum level of testosterone. Accordingly, given that honey is very rich with antioxidants, administration of honey may enhance the performance of Leydig cells, and hence the production of testosterone, mainly by enhancing the antioxidant defense mechanism. Accordingly, it can be suggested that honey administration is beneficial, at least, to maintain normal testicular tissue, which afterwards positively influence the production of testosterone. US National Institute of Health also warns consumers about taking yohimbine supplements if they suffer from schizophrenia, anxiety, depression, or posttraumatic stress disorder . Adverse events mostly due to self-administration of yohimbine have been reported since 1980s. The side effects of yohimbine include high blood pressure, increased heart rate, manic reactions, bronchospasm, palpitations, insomnia, anxiety, irritability, shivering, sweating, nausea, flushing, and headaches which all can be attributed to its central adrenergic activity 26, 30. Companies on Trustpilot aren't allowed to offer incentives or pay to hide reviews. Claim a refund if your order doesn't ship, is missing, or arrives with product issues No review focuses on side effects. Most Royal Honey Male Enhancement reviews are positive. Therefore, the supplement is a good alternative for Royal Honey Male Enhancement. Ginkgo extracts have been tested as a treatment for antidepressant-induced sexual dysfunction, which is a common side effect in depressive disorder therapy, especially when using selective serotonin reuptake inhibitors (SSRIs). Side effects subjectively reported by fora users were altered menstrual cycles, moodiness, cramps, gastritis, and insomnia (see Table 2). In 1985, Linden et al. have reported a case of a 16-year-old girl who experienced an acute dissociative reaction accompanied by weakness, paraesthesia, incoordination, anxiety, headache, and chest pain after the ingestion of an aphrodisiac called “yo-yo,” which has been later identified as yohimbine . This caused the hospitalisation of two female patients aged 34 and 21 in Hong Kong for acute hepatitis symptoms. Stand out with Honey Bae, a high-performance male enhancement honey supplement formulated for results and flavor. The supplement is also a sweetener for various products such as smoothies. For example, under energy enhancement, the supplement can increase male vitality. Royal Honey Male Enhancement reviews show that the supplement is a sexual stimulant. It was reported that oxidative stress reduces both enzymatic and non-enzymatic antioxidant reservoir in Leydig cells . It is well-known that the state of oxidative stress diminishes the function of the cell 53, 54, which may be attributable to increased levels of oxidative injury to the main functional biomolecules (e.g., proteins) . Above and beyond, it was suggested to be a useful marker for determining the variety of honey (i.e., botanical origin of honey) . While, in both human studies, the dose used was 20 g per day over approximately 3–12 weeks duration. Figure & Data Although Ginkgo extracts have been suggested for the treatment of female sexual arousal disorders , no placebo controlled randomised trial has been reported. Among the most frequently used in sexual enhancer products are Epimedium grandiflorum and Epimedium sagittatum. A further trial assessed the effects of maca in patients with erectile dysfunction using the International Index of Erectile Function Questionnaire and showed significant effects . Zheng et al. reported increased sexual behaviour in male rats and mice and decreased latency to erection in testes-removed rats following oral administration of lipid extracts of maca roots . With the advent of Internet, maca has become a common ingredient of sexual enhancer products available worldwide. In general, regardless of its variety, honey is a natural product and an ancient part of humans' food . Other disorders of deficient levels of testosterone include depression 17, 18, anxiety 17, 19, and fatigue . Since 1935, where the name “testosterone” was firstly coined, as per Scopus and PubMed data bases, to date, there are more than one hundred thousand research studies on testosterone and its biological perspectives; more than one-third of these studies were published in the last decade. This was conducted by searching PubMed, Scopus, and Embase electronic databases for research articles from May 1993 through April 2019 using the keywords “honey” and “honeybee” versus “testosterone”. CBPOs work closely with FDA to enforce food and drug import regulations to keep these types of potentially harmful products from entering our commercial markets.” Is it true that honey calms coughs better than cough medicine do? Creatine is one of the most well-researched supplements, but myths about its effects on sexual health—like erectile dysfunction—still persist.People commonly use honey orally to treat coughs and topically to treat burns and promote wound healing.In this context, unscrupulous manufacturers/retailers are exploiting the common belief that “natural” products are healthier alternatives to pharmaceutical treatments and infiltrate undeclared harmful psychoactive substances in their products .FDA Investigators advised the product may contain hidden drug ingredients and is subject to an import alert.In addition, honey has been found to contain various bioactive compounds (e.g., phenolic acids) that may improve testosterone production.Although Ginkgo extracts have been suggested for the treatment of female sexual arousal disorders , no placebo controlled randomised trial has been reported. Honey is sweeter than granulated sugar, so you might use a smaller amount of honey for sugar in some recipes. Both honey and sugar will affect your blood sugar level. Generally, there's no advantage to substituting honey for sugar in a diabetes eating plan. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. There's currently no evidence to show how honey might interact with other drugs. The side effects of yohimbine include high blood pressure, increased heart rate, manic reactions, bronchospasm, palpitations, insomnia, anxiety, irritability, shivering, sweating, nausea, flushing, and headaches which all can be attributed to its central adrenergic activity 26, 30.In an analysis of microbial loads of various illicit ED drugs, 23% were contaminated with more than 103 colony-forming units (CFU), and 69% had elevated levels considered within acceptable limits.However, several case reports of side effects to herbs and herbal products have been reported 8, 9, such as on- and off-target effects from biologically active ingredients, side effects caused by contaminants, and herb-drug interactions.These patients with higher socioeconomic statuses having the resources to pay for pharmaceuticals out-of-pocket, combined with the stigma of ED, creates an environment ripe for an illicit market.Most online reviews show that the formula helps boost libido in men.With the advent of Internet, maca has become a common ingredient of sexual enhancer products available worldwide.In 1993, Sandler and Aronson have described the development of progressive renal failure, cutaneous eruption, and a lupus-like syndrome in a 42-year-old Afro-American man following yohimbine use . Furthermore, as mentioned earlier, embarrassment with potency issues leads patients to avoid physician visits. This in turn could lead to a decreased demand for cheaper alternative counterfeit options. While the market for counterfeit pro-erectile medications is partially driven by the cost of prescription drugs, this reality could soon change. The companies issued warnings have 15 days to either address the issues of their products or provide information on why their products don’t violate the law. Your healthcare provider can review your medical history and perform any necessary tests to determine the best medication or lifestyle approach to address your concerns. Instead of trying an unproven supplement, visit your doctor if you have low libido or erectile dysfunction. Once the active constitutes of the products were identified, a comprehensive literature search was carried out using PsycInfo and PubMed. The use of unlicensed food and herbal supplements to enhance sexual functions is drastically increasing. Furthermore, counterfeit PDE-5i often contain improper dosing and contaminants that may place patients at direct risk. However, by doing so, many of these patients are unknowingly subjecting themselves to significant health dangers. A recent review on the pharmacokinetic properties of these substances concluded that the available pharmacokinetic data are rare and more studies need to be conducted . These extracts have also been suggested to increase NO bioavailability, which may have positive impact on sexual function . Ginkgo extracts have been suggested to improve sexual function by improving the blood flow to the brain as well as to the genital organs. A recent meta-analysis of 28 clinical studies with Ginkgo has found no significant effect on cognitive function . Furthermore, 11.5% of patients being evaluated for a PDE-5i prescription had a new underlying disease detected (26). Currently, evidence suggests that ED is not only correlated with cardiovascular disease due to shared medical comorbidities, but is, in fact, an independent risk factor for cardiovascular disease. Before PDE-5i are prescribed, patients must be evaluated for potential drug interactions and warned of the absolute contra-indications. Concurrent use of CYP 3A inhibitors or inducers can significantly alter the concentration of serum PDE-5i changing the side-effect profile, effectiveness of the medication, or severity of drug interactions (21). Its leaves are usually boiled to make an infusion with the aim of intensifying sexual sensations; moreover, when smoked, damiana leaves may produce similar effects to marijuana . Though currently interspecies transmission has not been yet demonstrated, the presence of CWS prions in animal muscle, fat, glands, and antler velvet may expose humans to infection by handling or consumption of diseased cervids products 89, 90. Ginkgo extract has been suggested to affect platelet aggregation, which may not only be useful in prevention of pathological events as thrombosis, but may also cause spontaneous bleeding in healthy individuals or patients treated with anticoagulants such as warfarin and aspirin . Therefore, still, so many research studies have focused on enhancing serum levels of testosterone in males. CBPOs concurred as the honey products had labels claiming “you are harder now,” and seemed to be promoting sexual enhancement, weight loss, and body building. In conclusion, the four substances, yohimbine, maca, horny goat weed, and Ginkgo biloba, commonly found in sexual enhancement products carry potential safety risks particularly in psychological context. For the purposes of this paper, the term “counterfeit” will be used to encompass all forms of SSFFC medications. The counterfeit drug market is a nebulous and constantly evolving entity that has become increasingly difficult to define and quantify. Furthermore, PDE-5i can have potentially dangerous interactions with other pharmaceuticals that are rarely warned against with counterfeit PDE-5i. One important factor behind such increased research intention is the impact of testosterone on humans' health, particularly males. However, further research studies on humans, mainly clinical trials, in this specific research approach are still needed to confirm the effect of honey on testosterone. We did not have any possibility to ascertain whether the substance the online alleged drug users were taking was only a sexual stimulant or a combination of various products. In this context, unscrupulous manufacturers/retailers are exploiting the common belief that “natural” products are healthier alternatives to pharmaceutical treatments and infiltrate undeclared harmful psychoactive substances in their products . In reviews of the efficacy and safety of Ginkgo extracts in human subjects, no serious side effects were reported in clinical trials and side effects were similar to those seen in the placebo groups . An overview of systematic reviews on various complementary medicine products for sexual dysfunction in elderly patients has found that the evidence for maca was insufficient . Currently, yohimbine-containing products are advertised on the Internet not only for treating erectile dysfunction and enhancing sexual performance, but also as a fast weight-loss and body-building supplement 15–17. Administration of ferulic acid at 50 mg kg−1, for 8 weeks, restored serum testosterone levels in male rats with lead-induced testicular damage . Also, ellagic acid, rosmarinic acid, p-coumaric acid, and ferulic acid are phenolic compounds present in honey and were found, whether directly or indirectly, to have positive effects on serum testosterone. The possible impact on subjects with psychiatric disorders, usually at risk for sexual disjunctions and therefore possible consumers, may be devastating. The frequent occurrence of side effects and the potential induction of symptoms of psychiatric interest, such as mood elevation, anxiety, hallucinations, and other psychotic symptoms, are issues that need to be clarified and constantly monitored at the international level 105, 106. This represents a growing public health threat, which is putting the population at risk. Creatine is one of the most well-researched supplements, but myths about its effects on sexual health—like erectile dysfunction—still persist. Some Royal Honey male enhancement reviews show that the supplement does not contain Viagra. In addition, honey has been found to contain various bioactive compounds (e.g., phenolic acids) that may improve testosterone production. But the few studies that do exist were conducted on animals.Sealed in individual packets, they contain honey and other natural ingredients, such as black ginger extract, vitamin C, ginseng, and maca root, says Seth D. Cohen, MD, MPH, a urologist at NYU Langone in New York City.Others seek to bypass the legitimate healthcare system due to either embarrassment of the underlying condition or desire for cheaper alternatives.Accordingly, it can be suggested that honey administration is beneficial, at least, to maintain normal testicular tissue, which afterwards positively influence the production of testosterone.The plasma concentration of yohimbine does not appear to correlate with the dose of the compound administered .For instance, it increases the levels of nitric oxide in this blood.Companies can ask for reviews via automatic invitations.Microbial growth analysis of phosphodiesterase-5 inhibitors (PDE-5i) products (29).Interaction could lead to dangerously low blood pressure levels. They found that maca had only a small effect on sexual behaviour and locomotor activity but no effect on anxiety . In a further study, the same group has demonstrated that the hexanic extract of maca had more effect on sexual behaviour of rats than the methanolic and chloroformic extracts . Cicero et al. demonstrated that sexual behavioural activity as well as locomotor activity was increased in rats treated with pulverised maca root orally . Maca extracts have been shown to contain benzyl glucosinolates and polyphenols, (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA), and p-methoxybenzyl isothiocyanate among many other chemicals . “These manufacturers know their products are mislabeled, adulterated, and contain harmful hidden drugs and chemicals. These products are often represented as being “all natural”. FDA Investigators advised the product may contain hidden drug ingredients and is subject to an import alert. It has been estimated that approximately six million men in the EU purchase these products from the Internet . The last Lust component is L-arginine, an amino acid believed to have positive effects on impotence and infertility . Another study has shown that Muira puama improved sexual desire, sexual fantasies, and the ability to achieve orgasm in 65% of women with prior sexual dysfunction . Waynberg reported in 1994 that 60% of men with low libido have reported increased sexual desire and 50% of men with poor erection have reported improved erectile function following Muira puama administration . It has recently been found in products advertised on the Internet to increase sensuality, especially among women , as legal and safer alternative to Cannabis and sold as “mystical incenses” 93, 94. Some Royal Honey male enhancement reviews show that the supplement does not contain Viagra.Therefore, the supplement is a good alternative for Royal Honey Male Enhancement.Finally, once the active constituents of these products were identified, a comprehensive literature search was carried out using PsycInfo and Pubmed databases.It is estimated that less than 1% of side effects or adverse events for herbal products are recorded with the current surveillance systems .It is difficult to determine the true frequency of side effects from herbs and herbal products, since surveillance systems are much less extensive than those in place for pharmaceutical drugs.The negative reviews are primarily concerned with pricing, quality, and ingredients. Products and Services These doses, in humans, for an adult male of 60 kg weight, equals to approximately 13 mg to 2.35 g kg−1 of body weight . However, it is worth mentioning that the exact composition of honey depends on its floral source as well as the environmental and seasonal factors . Chemically, testosterone belongs to the androstane class, which is a 19-carbon tetracyclic hydrocarbon structure . Testosterone is an anabolic steroid considered as the foremost sex hormone in males 1, 2. “If a product is as safe and legitimate as the manufacturer claims, why was it incorrectly manifested as a dessert and kitchen set? Our research and development team has developed the Miracle Honey blend to heal sexual impotence and sterility, as well as provide a vast energy source.” They were also found not to contain any honey at all, but mainly corn syrup. The package was manifested as “Kitchen ornament and Turkish delight set” with a consignee in MS. Upon physical inspection, CBPOs found the shipment to contain 120 boxes (1,440 packets) of three different kinds of honey that had not been manifested. A further limitation may be that the present findings do rely mostly on what is reported by users. Collectively, as a result, the main stream of this specific research context reveals that oral administration of honey increases serum testosterone level in males. As illustrated in the Table 1, all summarized studies that show the effect of honey on testosterone were conducted on male population. Here, we intended to systematically discuss and summarize the impact of honey on serum levels of testosterone. One such example in this specific research context was to explore the effectiveness of honeybee on testosterone, especially various honeybee products are used in folk medicine to treat numerous diseases/disorders 22, 23, 24. Mechanistically, honey may increase serum level of testosterone by increasing the production of luteinizing hormone, enhancing the viability of Leydig cells, reducing oxidative damage in Leydig cells, enhancing StAR gene expression, and inhibiting aromatase activity in the testes. The supplement has a fantastic taste. The supplement has been reviewed online by many customers. This property usually is effective in males between the age of 20 and 52. Moreover, the component is effective in treating erectile dysfunction. Furthermore, it helps boosts immunity and increases the energy levels in the body. The product is also a natural sweetener. Furthermore, the product does not undergo heat procedures. Therefore, it helps boost energy levels in the body. Possible reasons behind such a risky behaviour include (a) the embarrassment to speak with a doctor, (b) the thought that buying them online would be the fastest and cheapest way to solve the problem, (c) curiosity, (d) peer-pressure, and (e) the increase of sexual confidence and performance . Because of their partially synthetic and partially natural composition, some sexual enhancer substances are defined "mixed." Lust is a stimulant made up of Sida cordifolia extract. This herb may be found in plant markets or in herbal formulations, usually sold to increase physical, mental, and/or sexual performance. The flower may indeed induce both narcotic and euphoric effects and, if taken in large amounts, may cause slightly hallucinogenic symptoms . Most of the reviews are positive. There are several Royal Honey Male Enhancement reviews available online. Infused with natural ingredients, each box contains 12 sachets (15g each) designed for convenient use and maximum effectiveness. Thus, cholesterol cleavage occurs into pregnenolone in Leydig cells, which increases the synthesis of testosterone. A study conducted by Mohamed et al. (2011) showed that honey at 1.2 g kg−1 day−1, for 13 weeks, increases the number of Leydig cells, seminiferous tubules diameter, and epithelial heights of the testes in male rats with cigarette smoke-induced testicular damage . Therefore, mechanistically, serum testosterone level is directly influenced by the amount of luteinizing hormone produced. As summarized in the table, the effect of honey on testosterone is ranging from “positive” (+) to “no change” (±); there is no any “negative” (-) influence of honey administration on testosterone level. And, the duration of supplementation in these studies were ranged from ∼14 days to ∼50 days. The honey doses that are utilized in the in-vivo system studies were vary from ∼80 mg to 14.5 g kg−1 of body weight per day. Blue Bull Extreme Extra Strength Male Enhancement Honey 15 Pouches x 22g Each Minimum Case of 12 Displays The Edge upholds the highest standards of health journalism. Understand the bigger picture of midlife health, from hormones to healthy aging—delivered to your inbox every Monday. If medication is appropriate, your doctor will provide a prescription and monitor for side effects and efficacy.” Max Fuel Male Enhancement is a natural performance-boosting supplement crafted to support men’s sexual wellness, stamina, and vitality. Beast Force Male Enhancement is a natural dietary supplement designed to support male vitality and performance. Each sachet blends rich floral honey with potent herbal extracts to support libido, stamina, and sexual vitality. This supplement can increase male vitality. The negative reviews are primarily concerned with pricing, quality, and ingredients. Further, quercetin at 20 mg−1 kg−1, for 14 days, restored the plasma levels of testosterone in male rats with sulphasalazine-induced reproductive toxicity . In addition, quercetin supplemented at approximately 10 mg−1 kg−1 for 3 weeks significantly enhanced testosterone level in male rats with atrazine-induced reproductive damage . Moreover, bee products mixture (80 mg honey, 60 mg pollen, 20 mg larvae, 20 mg royal jelly, and 2 mL propolis) twice a day (30 and 60 mg) protected against pentylenetetrazole-induced testicular damage (particularly Leydig cells and seminiferous tubules) in male Wistar rat . According to this evidence, the positive effect of honey on serum testosterone level is modulated by increased production of luteinizing hormone. Moreover, male rats with ischemia/reperfusion induced testicular injury fed honey at 5% of the diet had higher serum levels of luteinizing hormone compared with the control . If you have diabetes, talk with the healthcare professional who helps manage your condition. If you are prescribed a clear liquid diet before a medical test, be sure to follow the diet instructions exactly. Only use the clear liquid diet as directed by your healthcare professional. Such biological properties has let chrysin, especially when used at high doses, to be used as a testosterone-boosting agent 61, 64, 65, 66. Chrysin has been recognized as a potent inhibitor of the enzyme aromatase, which is an enzyme catalyzes the conversion of testosterone to estradiol 62, 63. It has been shown that chrysin, orally supplemented at 50 mg kg−1 day−1, for 2 months, significantly increased the testicular level of glutathione as well as the activity of the antioxidant enzymes (catalase, glutathione peroxidase, and superoxide dismutase) . Even though 57 of 58 products were labeled as “all natural” and no sample claimed to include synthetic substances, 81% contained PDE-5i. The common link between these patients was the use of an ED supplement that contained glyburide (a sulfonylurea used to treat diabetes), as well as illicit PDE-5i (31). As a result, many so-called “natural” supplements, in fact, contain active ingredients of prescription strength drugs that could be potentially harmful. A doctor can review your medical history and order lab tests to determine the best course of action. “It’s extremely important for men experiencing erectile dysfunction to talk to a doctor about their symptoms,” says Jack Jeng, M.D., Chief Medical Officer at Hone Health. Again, FDA approvals of Cialis and Viagra are restricted to use under the supervision of a licensed health care professional. Consumers should immediately are advised to stop using the product and may return it for a full refund. Naturally dried hypocotyls have been used for centuries by native Andean populations as aphrodisiac, energizer, and enhancers of fertility and sexual function . Yohimbe should be used with caution when taken with medicines for high blood pressure, tricyclic antidepressants, or phenothiazines (a group of medicines used mostly for mental health conditions such as schizophrenia). As a result, the Department of Health opened an investigation and appealed to members of the public not to buy or consume the product . More recently, Yohimbine was detected in a product labelled as OxyELITE Pro and sold online as slimming pills. Male Performance Enhancement VIP Royal Honey Pack for Men Premium Health Supplement No potential conflict of interest relevant to this article was reported. Find out how we combat fake reviews. Formulated to support testosterone balance, stamina, libido, and overall vitality, they offer a tasty alternative to traditional pills. Primo TRT Male Enhancement Gummies elevate male confidence with these easy-to-take daily gummies designed for men’s wellness. Entering the New Year 🎆, I feel energized and optimistic about maintaining healthy progress. By bypassing the legitimate healthcare system, users of counterfeit PDE-5i bypass screening for concurrent medical comorbidities, as well as proper education and warnings of PDE-5i use. Strategies to limit counterfeiting should be multi-faceted and target prescribing healthcare professionals, pharmaceutical companies, regulatory authorities, and patients. Unsuspecting patients often seek alternative treatments of ED due to embarrassment and lower cost, but also because of the perception that “all natural” products are somehow safer than synthetic medications. Recently, in January of 2016, the FDA announced warnings against 40 products marketed as dietary supplements that contained undeclared PDE-5i (33) (Table 3). The Food and Drug Administration is advising consumers not to purchase or use Royal Honey VIP, a product promoted and sold for sexual enhancement. We process personal information and consumer health data to provide you with our products and services and maintain essential website functionality. And in 2019, the FDA warned that sexual enhancement pills sold online could contain hidden ingredients like sildenafil, the active ingredient of Viagra. In April, the FDA warned of 18 other honey-based sexual supplements with hidden drugs. Chrysin (5,7-dihydroxyflavone) is a flavonoid presents at high levels in propolis and honey . In particular, such oxidative stress state, when occurs in Leydig cells in the testes, may reduce testosterone synthesis , and hence the level of serum testosterone. In addition, assessed by electron micrograph, honey was found to maintain viable and normal structure (e.g., normal cellular organelles and nucleus) of Leydig cells in the testes of male marmosets . Offering incentives for reviews or asking for them selectively can bias the TrustScore, which goes against our guidelines. Verification can help ensure real people are writing the reviews you read on Trustpilot. Labeled Verified, they’re about genuine experiences.Learn more about other kinds of reviews. Companies can ask for reviews via automatic invitations. People who write reviews have ownership to edit or delete them at any time, and they’ll be displayed as long as an account is active. In addition, caffeic acid phenethyl ester, given intraperitonially at 10 μmol kg−1, for 30 days, enhanced serum testosterone level in male rats with cadmium-induced reproductive toxicity . Moreover, male rats with di-(2-ethylhexyl) phthalate-induced reproductive damage administered quercetin at 0.09 g−1 kg−1 day−1, for 15 days, had higher serum levels of testosterone compared with the control . For example, quercetin supplemented for 15 days at approximately 50 mg kg−1day−1 was found to enhance serum level of testosterone in male rats with arsenic-induced reproductive toxicity . Directly, adult male rats exposed to cigarette smoke supplemented, for 13 weeks, with Tualang honey at 1.2 g−1 kg−1 day−1 had higher level of serum testosterone compared with the control .