But do testosterone nutritional supplements work? But testosterone levels decline with age. This proprietary blend of pomegranate and cacao seed extracts has been shown to promote testosterone production in laboratory studies. The individual combination supplements were evaluated for active ingredients and product claims. Maintaining healthy testosterone levels can help support a man’s mood, healthy weight and sexual health. Testosterone Elite combines nutrients that work together to support youthful testosterone production and healthy hormone levels. These nutrients complement each other’s mechanisms of action, supporting testosterone production and encouraging youthful free and total testosterone levels. Testosterone Elite† combines pomegranate and cacao extracts with luteolin to support testosterone production and promote youthful free testosterone levels. We also noted that despite a variety of marketing approaches among these 5 supplements, several shared identical ingredientprofiles. Physicians can point tocase reports demonstrating that T-Booster supplements have included banned substances, including steroids, resulting in adverse sideeffects during use11,12. Research into the impact of these technologies on consumer behaviorwithin the health space is still emerging. Accurate comparisons between the 37 human studies were not possible given non-uniformsupplementation protocols and sampling timelines. Healthy testosterone levels are crucial for muscle growth, libido, and mental clarity, helping you feel and perform at your peak.Maximize Absorption with BioPerine – Our formula includes BioPerine, enhancing the absorption of all ingredients. However, only 24.8% of these had data to support these claims, based on their components. Despite the FDA statement against the use of supplements to treat conditions, 90% of “T booster” supplements claimed to boost T. The laxity of FDA supplement regulation is well established, and has enabled T-Boosters to proliferatewithout rigorous quality control, ingredient standardization or verification of touted benefits . Despite this variability, prominent ingredients in many T-Boosters include horny goat weed,saw palmetto and fenugreek. Le et al. noted that reimbursement and insurance coverage for TTh lack transparency and hinder patientsfrom receiving appropriate care for hypogonadism. Several factors contributed to this decline, including a 2015 Food and DrugAdministration (FDA) safety announcement attributing a potentially increased cardiovascular risk to TTh. Zinc and magnesium deficiencies are linked to low testosterone and they’re very important minerals for maintaining normal bodily functions. And the testosterone complex contains Maca, Tribulus, Fenugreek, Tongkat Ali, and DIM. And this powerhouse contains three amazing compounds for more than just testosterone boosting benefits. Sasparilla is used as a sexual stimulant and Wild Yam Extract which may have a subtle effect on testosterone and sexual enhancement. In the absence of more definitive human data,patients should be cautioned before considering the use of T-Boosters, particularly given the availability of highly effective drugtherapies. However, accurate comparisons between the 37 human studies were not possiblegiven non-uniform supplementation protocols and sampling timelines. Physicians and policymakers should be aware that increased transparencyabout insurance reimbursements and low-cost compounded drugs for conventional TTh can potentially help alleviate the drive of patientsseeking alternative therapies for hypogonadism. Relatively low levels of zinc over-supplementation have been shown to interfere with the utilization of copper and iron and to adversely affect high-density lipoprotein cholesterol concentrations. It is worrisome that two supplements had greater than the UL of zinc. RDA information was not available for many of the individual components for the “T boosters”. However, it is even more concerning that some of these supplements may in fact decrease serum T. Of concern, 10.1% of components had published data that found a decrease in T with supplementation. Among the 10most common ingredients, fenugreek had the highest ratio of human to total studies at 64% (7/11). There was no uniform distribution of articles among the 10 most common supplements. We assessed how many studies examining each of theseingredients have been published and grouped these based on in vivo human and animal studies, invitro studies, and other types of studies. Boron, horny goat weed, and tongkat ali extractwere present in all 5 supplements. Thetop 5 T-Boosters had an average ± SD of 2,761 ± 5,112 reviews (Range 6-11,158). First, this analysis was limited to 5 T-Boostingsupplements that were identified as the top hits on a single search. The fact that many reviews after filtration continued to indicate product efficacy across the‘energy’ ADAM category provides insight into consumer’s subjective sense of product efficacy. We observed that nearly 30% of product reviews continued to report improvements in energy followingidentification of trustworthy reviews. Furthermore, many of theproduct reviewers failed to explicitly describe the supplementation regimen that they followed. See what products members are adding to stacks However, the liver injury observed here may not be confidently linked to product consumption as the subject later reported that the following recovery he consumed two more courses of the booster with no side effects. According to researchers based in the US, about 13% of the annual cases of acute liver failure are attributable to idiosyncratic drug- and/or supplement-induced liver injury. However; one cannot be completely confident in terms of the quality and efficacy of such products because of several reasons, such as the possibility of bad storage conditions and originating from an unreliable source. Testosterone booster products obtained from trusted sources and administered as per the recommendations of the manufacturer may still present some health risks. Over the years, some consumers of testosterone boosters have complained of kidney and liver abnormalities that could be linked to their use of boosters. Elevated testosterone levels have been demonstrated to increase the growth of body muscles and contribute to better activation of the nervous system, resulting in more power and strength, a better mood, enhanced libido, and many other benefits. Customers find the testosterone booster effective and well-made with premium ingredients. Supplements contained a median 1,291% of the RDA for vitamin B12, 807.6% of vitamin B6, 272% of zinc, 200% of vitamin B5, and 187.5% of vitamin B3. There were a mean 8.3 components per supplement (range, 29; median, 7; mode, 6; standard deviation, 5.52; interquartile range, 1–7). Only articles that looked at the effect of supplementation were included. We chose Google because it is the most widely used search engine, comprising 74.5% of Internet searches . Physicians should be aware of T-Booster contentsand their efficacy to better counsel patients. In addition, 17% of users reported increased libido, and 29% increased sports activity. The most extensively studied ingredient was sawpalmetto extract, with 53 articles including 10 human studies. Despite being marketed under different names, several T-Boosters, namely Alpha Boost and Extra Strength as well as Pro-Tand Iron Brothers all had the same ingredients, including quantities of each ingredient. Six Star Nitric Oxide Supplements for Me… Studies show D-Aspartic Acid to play a role in the release, regulation, and synthesis of LH and testosterone in humans and rats. But, results have been mixed for its testosterone-enhancing properties. But according to the American Urology Association (AUA), Low blood testosterone is less than 300 nanograms per deciliter (ng/dL). Now, testosterone is a sex hormone produced in the testes but women also have smaller amounts of testosterone. And B6 is crucial for the immune system and hemoglobin support. Other search terms such as “Testosterone Supplement” yielded products that contained exogenous sources of hormone, which is beyond the scope of this study. The purpose of this study was to evaluate the composition of “T boosting” supplements, their advertised claims, and compare them with both the published literature and FDA recommendations. We evaluated the composition and advertised claims of “T boosting” supplements, and supporting published evidence. Men take testosterone (T) boosting supplements to naturally improve T levels. Testosterone Elite is ideal for men looking to support youthful testosterone levels. Multivitamin rating based on results of the 2024 ConsumerLab.com Survey of Supplement Users. Our convenient, once-daily formula is gluten-free and non-GMO—it’s the perfect complement to a testosterone-friendly lifestyle. What’s in our testosterone-friendly formula? This enzyme converts testosterone into estradiol (estrogen). Effect of testosterone boosters on body functions: Case report Testosterone boosters are not at all a substitute for proper treatment.Men need testosterone to build muscle and maintain sexual health, but levels decline over time.Le et al. noted that reimbursement and insurance coverage for TTh lack transparency and hinder patientsfrom receiving appropriate care for hypogonadism.One-hundred nine unique components were found, with a mean number of 8.3 per product.But there are good products out there which will make a small difference.And this powerhouse contains three amazing compounds for more than just testosterone boosting benefits.Now, ZMA isn’t necessarily a “testosterone booster” but these nutrients are essential for testosterone production.However, it is even more concerning that some of these supplements may in fact decrease serum T. T-Booster marketing proclaims that these products can naturally improve T levels while ensuring lower cost andcomparable efficacy to FDA-approved therapies such as testosterone. But, studies show it might increase testosterone levels. A testosterone booster is supposed to… well, boost your testosterone levels. Influx Inspire Test Booster help boost testosterone levels and take back your manhood, this natural supplement is designed to help increase your circulation and blood flow. Marked increase in the levels of ALT, AST, and gamma-glutamyl transferase was observed after consuming the first course of the commercial testosterone booster, and they started to decline after the 2nd and 3rd course. Best For Energy – Xjus Premium Test + Energy Booster Estrogen is necessary for male health, but an excess conversion can deprive the body of needed testosterone and leave it in an estrogen-dominant state.In addition, only the first and most frequently appearing 50 supplements were included in the study, acknowledging that other products and supplements may be available that were not studied here.So, when brought up to normal levels, testosterone is increased.Please note that during theproduction process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journalpertain.The FDA does not issue RDA and upper tolerable limit data for herbal supplements.Test boosters are really only beneficial for those with low testosterone.However, if you do suffer from low testosterone levels, then you might see some benefit.For 27 individual supplements (24.8%), there was data showing an increase in T with supplementation. The use of TTh nearly tripled between 2001 and2011, rendering therapies for hypogonadism one of the most rapidly growing pharmaceutical product categories. The incidence of hypogonadism increases with age and affects approximately 4-5 million men in theUnited States. Our investigation revealed that limited human studies have evaluatedT-Boosters, resulting in no definitive findings of efficacy. Strengths include the novel approach to assess consumers’ perceptions and satisfaction of T-Boosters, andsummary information that clinicians can provide patients. Many had supra-therapeutic doses of vitamins and minerals, occasionally over the UL. Ninety percent of supplements claimed to “boost T”, 50% “improve libido”, and 48% “feel stronger”. Estrogen is necessary for male health, but an excess conversion can deprive the body of needed testosterone and leave it in an estrogen-dominant state. There are no additional charges, you pay only for the supplements you order. These products are not intended to diagnose, treat, cure, or prevent any disease. If you’re pregnant, please speak with your doctor before starting any new supplements. For 27 individual supplements (24.8%), there was data showing an increase in T with supplementation. Most frequently, claims to “boost T or free T”, “build body lean mass or muscle mass”, or “increase sex drive or libido” were advertised by the supplements. A total of sixteen general claims to benefit patients were made by these supplements. A structured PubMed search was the performed for “testosterone” and each of the 109 components found in the supplements. Testosterone production is reduced gradually in men starting from the age of 30. Besides, the hormone has other vital functions as the basic chemical composition of testosterone is steroidal; and steroids are known to have significant physiological, as well as psychological, effects in male individuals, especially adults. Further studies with large sample size and for a long period need to be done to confirm the current findings. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Taking action for change is essential to make something happen for a bright and productive day. Money shouldn’t be the reason why you can’t boost your testosterone levels. And each serving has the best natural testosterone-supporting ingredients available which include Horny Goat Weed, Tongkat Ali, Wild Yam Extract, Sasparilla, and Boron. Every serving has 5,000 IU of D3 which is the most important vitamin for testosterone health. So, we have picked test boosters which have a good rating, and which are overall a great value… Testosterone boosters are not at all a substitute for proper treatment. Testosterone boosters are not able to address these problems and may potentially only slightly improve symptoms. D-Aspartic Acid – This amino acid is a very popular ingredient in test boosting products. But there are good products out there which will make a small difference. However, it’s hard to give a definite answer on its efficacy for increasing testosterone levels. However, if you do suffer from low testosterone levels, then you might see some benefit. This is an effective combination for getting your testosterone levels just a little higher. Among these ingredients, we’ve not discussed Sasparilla and Wild Yam Extract. This 100% natural test booster is Pharmacist recommended and the #1 recommended formula by men over 30. Safe, natural ingredients. Boron is a trace mineral which is essential for maximizing testosterone’s positive effects in the body. Contains the most potent, biologically active EuryPeptides on the market today created by the researchers. While we recognize that more work isrequired in validating ReviewMeta findings that facilitate the correlation between customer reviews and quantifiable effects of thesesupplements on hypogonadal symptoms, there are no other comparable services. Understandingpatients’ overall satisfaction with these products can enable healthcare providers to target future counseling efforts. The positive linear correlation between the number of“fails” detected by ReviewMeta supports the efficacy of the ReviewMeta service and leads to doubt regarding the accuracyof these product reviews. Nearly 66.6% of reviews among the top 5 supplements were filtered out by the ReviewMeta.com algorithm. A total of 10.1% contained components with data to demonstrating a negative effect on T. We chose Google as our search engine because it is the most commonly used search engine , however, the addition of other search engines (Yahoo or Bing) may yield different results. Supplements contained a median 1,291% of the RDA for vitamin B12, 807.6% of vitamin B6, 272% of zinc, 200% of vitamin B5, and 187.5% of vitamin B3 (Table 4). In short, these vitamin and herbal substances may not be as safe as the public perceives them to be. Supplementary Material In addition, only the first and most frequently appearing 50 supplements were included in the study, acknowledging that other products and supplements may be available that were not studied here. In this study we sought to evaluate the composition of “T booster” supplements, their advertised claims, and we compared this with the published literature and RDA. Regarding the results of our PubMed review, there were no studies looking at the effect of the individual supplements on T levels for 67 of the supplements (61.5%). The filtration of most reviews leadsus to question the validity of the comments affiliated with each supplement. We observed that only 19% of the studies examining the ten most common supplementingredients were conducted in human subjects. Several of thesemanufacturers did not report the exact quantities of active ingredients in their supplements, providing only lists of ingredients.Patients should be counseled regarding the minimal standardization of ingredients and concerns regarding supplement manufacturingprocesses35–38. This study aimed to evaluate the side effects and health risks of testosterone boosters among athletes. Testosterone boosters are supplementary substances that can be used for the purpose of increasing testosterone levels in the blood. Vitamin D3, B6, B12 and Zinc work synergistically to not only boost testosterone but also support immune function and bone health, vital for men’s overall wellness.Hormonal Harmony with DIM and Boron – DIM helps in metabolizing estrogen, balancing hormones, while Boron significantly increases free testosterone levels. Patients should be informed that “T booster” supplements may not have components with mechanisms to support their claims. While different search times produced results that were not relevant to this study, such as products with exogenous T and hormones, a different search phrase may have produced a varied supplement list. Our experts packed this men's health formula with potent, clinically studied ingredients to help you maintain optimal levels of testosterone. To get ahead of the game, it's time to start supporting your youthful testosterone levels with Testosterone Elite from Life Extension. Seeking to maintain healthy testosterone levels? At Fitness Volt, our mission is to empower every individual on their fitness journey by providing expert advice, the latest research, and comprehensive resources. But quality isn’t so common and that’s why it’s worth weighing the benefits of each product. And all contain herbs, minerals, and natural ingredients which are generally safe. From age 30, test levels drop off by about 1% every year thereafter. E-commerce is an increasingly popular option for consumers in researching and purchasing products14,16.Ninety percent of supplements claimed to “boost T”, 50% “improve libido”, and 48% “feel stronger”.Patients should be informed that "T booster" supplements may not have ingredients to support their claims.The individual combination supplements were evaluated for active ingredients and product claims.At Fitness Volt, our mission is to empower every individual on their fitness journey by providing expert advice, the latest research, and comprehensive resources.We evaluated the composition and advertised claims of "T boosting" supplements, and supporting published evidence.Due to the growing interest in herbal ingredients and other dietary supplements worldwide, the use of testosterone boosters is becoming more and more mainstream among athletes, but several side effects were documented.Unlike drugs, supplements are not intended to treat, diagnose, prevent, or cure diseases, according to the FDA. A PubMed analysis as detailed in the methods was undertaken for the 10 most common ingredients used across all supplementsand is presented in Table 2. A total of 19 unique ingredients were identified across the group of supplements; eachsupplement consisted of an average of 9.8 ± 2.2 ingredients (Range 7-12). Supplement ingredients were aggregated and catalogued for each supplement, and the 10 most frequently utilized ingredientsacross the set of supplements were identified. The internet is increasingly becoming the default location for the acquisition of health and nutritional supplements14,15. T-boosters are not regulated by the FDA and lack a standardized composition,being composed of a myriad of ingredients. This abruptly increases the levels of liver enzymes after the first course may be attributed to the interruption effect of commercial testosterone booster on liver function as a result of the effects of its ingredients. Hence, this study established to help in the assessment of the side effects and health risks which could occur among athletes consuming testosterone boosters. In conclusion, administration of testosterone booster products, although obtained from trusted sources, may still present some health risks. Zinc and magnesium deficiencies are linked to low testosterone and they’re very important minerals for maintaining normal bodily functions.Among these ingredients, we’ve not discussed Sasparilla and Wild Yam Extract.But quality isn’t so common and that’s why it’s worth weighing the benefits of each product.The natural formula includes Ashwagandha, Tongkat Ali, and other vitamins.This is an effective combination for getting your testosterone levels just a little higher.There was no uniform distribution of articles among the 10 most common supplements.On review of the patient’s history, he was found to have undergone laboratory tests before starting to use the aforementioned testosterone booster product.However, only 24.8% of these had data to support these claims. Blood tests before and after using a testosterone stimulant After the single-week admittance into the hospital following the abdomen pain episode, the follow-up retinue uncovered that the athlete admitted earlier took two more courses (for 42 days) of the same product after he recovered. The daily dose was a single pack of Universal Nutrition Animal Stak (ingredients are listed in Table 1), following the exact direction of the manufacturing company hoping to get the best results. After that medical checkup, the athlete began to consume the product for 42 continuous days divided into 2 cycles (each cycle comprised 24 days). A physical examination that included blood pressure and pulse assessments showed nothing out of the ordinary, and the man appeared to be in good condition before product consumption. REDCON1 Total War Preworkout – Contains … Recent work by Cui et al. demonstrated that patients are increasingly seeking herbal and nutrient based supplements to addresshypogonadal symptoms9,10. The authors concluded that regulatory andstructural barriers were in part forcing patients to actively employ online marketplaces to research and procure alternatives toprescription testosterone. Analysis of top customer reviews from the first two pages ofreviews for each supplement revealed differences in ADAM score before and after ReviewMeta.com filtration. Amongst 37 human studies, 30% observed an increase in Tlevels, 3% a decrease, 46% no effect, and 22% were indeterminate. On review of the patient’s history, he was found to have undergone laboratory tests before starting to use the aforementioned testosterone booster product. However, despite this FDA statement, the “T booster” supplements made a host of claims. For 24.8%, or 27 out of 109 individual supplements, there was data showing an increase in T with supplementation. In general, the available literature supporting the claims made by the supplements was often sparse or non-existent. “The safest and most effective way for men to boost low testosterone levels is to talk with a medical professional or a nutritionist.”A testosterone booster is supposed to… well, boost your testosterone levels.The blood tests and reports suggested that the commercial product consumed might negatively affect several hepatic functions and resulted in slightly increased testosterone concentrations after the fourth course.“Many supplements on the market merely contain vitamins and minerals, but don’t do anything to improve testosterone,” Samplaski said.After that medical checkup, the athlete began to consume the product for 42 continuous days divided into 2 cycles (each cycle comprised 24 days).Many had supra-therapeutic doses of vitamins and minerals, occasionally over the UL.Zinc – An important mineral, zinc was shown in a study to have significant effects on testosterone levels after 20 weeks of intentional deficiency. And so, these test boosters get a bad rap. But, a lot of products are filled with stuff that doesn’t work! There are no artificial ingredients and Test Force is an all-natural product. Each batch of quality ingredients is clinically researched. Fifty “T booster” supplements were evaluated for active ingredients and product claims, discovered via Google search. There’s lots of ways to support healthy testosterone levels—including testosterone supplements. Though marketing, sometimes disguised as consumer reviews on online product pages,would lead consumers to believe otherwise, evidence that rigorously supports a positive impact of these products on testosteronelevels and hypogonadal symptoms is lacking. Patients should be counseled regarding the limited amount of datainvestigating the effects of these supplements on both testosterone levels and the male reproductive system more globally. A review of the literature supporting T-Boosters underscores the paucity of data available on the impact of T-Boosteringredients on serum testosterone levels. Testosterone boosters are used by many athletes worldwide to achieve a significant muscle mass increase within a short period of time. Laboratory tests were performed in between the courses to check if there were any marked discrepancies due to the recurrent use of the testosterone booster. The patient, a sportsman, described that he was taking a testosterone commercial booster product called the Universal Nutrition Animal Stak for the purpose of enhancing his testosterone profile to achieve a better performance and body composition. We observed that nearly 30% of product reviews continued to report improvements in energy followingidentification of trustworthy reviews.In conclusion, administration of testosterone booster products, although obtained from trusted sources, may still present some health risks.After the single-week admittance into the hospital following the abdomen pain episode, the follow-up retinue uncovered that the athlete admitted earlier took two more courses (for 42 days) of the same product after he recovered.Boron, horny goat weed, and tongkat ali extractwere present in all 5 supplements.Amongst 37 human studies, 30% observed an increase in Tlevels, 3% a decrease, 46% no effect, and 22% were indeterminate.Contains the most potent, biologically active EuryPeptides on the market today created by the researchers.All reviews from thetop 2 pages of comments were collected for each supplement, resulting in a total of 65 reviews, and analyzed using the ADAMquestionnaire as described in methods. The effects of Ashwagandha are well known and this herb is also an effective option for mental health and stress-reduction (Adaptogen). Vitamin D – This essential vitamin is important for human growth and development. However, a study did show TT to have therapeutic effects for men with low sperm counts. But, it may play a small role in stimulating testosterone-producing hormones. The claims and the number of supplements claiming these benefits are detailed in Table 2. The most common components for the supplements were zinc, fenugreek, vitamin B6, Tribulus, magnesium, boron, diindolemethane, Eurycoma longifolia, and Maca extract. For the T booster supplements surveyed, 109 components were identified. The present study is descriptive in nature, without direct patient or subject involvement, using commercially available online information on over-the-counter T supplements. Men may take dietary supplements in hopes of improving their endogenous T production. Claims like these can only legitimately be made for drugs, not dietary supplements.” . The US Food and Drug Administration (FDA) clearly states that, “Unlike drugs, supplements are not intended to treat, diagnose, prevent, or cure diseases. Despite their popularity, the scientific rationale for these products often remains unexplained or unproven. The reasons for this are unknown, but some of these men may be seeking alternative treatments, such as care at rejuvenation centers or using over the counter T supplements. In the absence of additional human studies, patients should becautioned before considering T-Boosters, given the availability of highly effective Food and Drug Administration approvedtherapies. The top 5 T-Boosters had an average ± SD of 2,761 ± 5,112 reviews and a rating of 4.56 ± 0.25stars. There are no reviews yet. People with low test levels may see an increase. We then surveyed the RDA and UL for each of the individual supplements. A full list of the individual components, with percent of supplements containing these components, is found in Table 1. It is important that these men have access to information that is evidence-based and will give them a realistic picture of what they can hope to see after using these supplements. However, despite this clear FDA statement, there continue to be products that either directly claim or imply to have certain effects on medical conditions. Related products A study showed it to increase free and total testosterone in sedentary and active individuals. So, when brought up to normal levels, testosterone is increased. One study showed a correlation between low Vitamin D levels and low testosterone. Tribulus Terrestris (TT) – Tribulus Terrestris contains many steroidal saponins but studies are not conclusive enough to prove it increases testosterone. The more “fail” resultsthat a supplement had, the more likely that it had questionable reviews.Thetop 5 T-Boosters had an average ± SD of 2,761 ± 5,112 reviews (Range 6-11,158).Supplement information, ingredients,and comments from the initial 2 available pages of reviews were collected and stored offline to ensure consistency in dataanalysis given the dynamic and routinely updated online marketplace.Most frequently, claims to “boost T or free T”, “build body lean mass or muscle mass”, or “increase sex drive or libido” were advertised by the supplements.Our convenient, once-daily formula is gluten-free and non-GMO—it’s the perfect complement to a testosterone-friendly lifestyle.Thesignificance of these fake product reviews is heightened by the fact that patients place high levels of trust in health-relatedinformation displayed online.D-Aspartic Acid – This amino acid is a very popular ingredient in test boosting products.Physicians and policymakers should be aware that increased transparencyabout insurance reimbursements and low-cost compounded drugs for conventional TTh can potentially help alleviate the drive of patientsseeking alternative therapies for hypogonadism.Whether you are a beginner or an elite athlete, we are here to support your goals with trustworthy and up-to-date information in strength, fitness, and nutrition.Blend of 17 ingredients to facilitate Energy levels, better body health and muscle support. Nineteen unique ingredients were identified across these T-Boosters, and literature review revealed 191 studiesinvolving the 10 most common ingredients, of which 19% involved human subjects, 53% animal models, 15% invitro studies and 12% case reports or review articles. The top 5 T-Boosters identified on July 22, 2018 were reviewedbased on price, ratings, reviews, manufacturer details, and ingredients. However, only 24.8% of these had data to support these claims. No data were found on 61.5% of supplements on their effect on T. However, with all testosterone products, it’s important to remember that the results will be subtle and whether or not they’re worth taking depends on the individual. At the beginning, a written informed consent was taken from a 30-year-old man for participation in this study. Anabolic–androgenic steroids (AASs) are synthetic derivatives of testosterone that are commonly used among athletes aged 18–40 years, but many reports have demonstrated the presence of numerous toxic and hormonal effects as a result of long-term use of an AAS. As a result, men may experience a number of physiological and psychological events, such as a lack of sex-drive, erectile dysfunction, acute depression, fatigue, low energy levels, and insomnia. Hence, testosterone blood concentrations slowly diminish as age progresses. Testosterone levels can also be affected by the activity of the enzyme aromatase. The most common reason is the inevitable process of aging, where the testes simply don’t produce the same amount of testosterone as they previously did.1-3 Unfortunately, as some of us get older, we ended up producing less and less testosterone. Less testosterone than your body needs. At CartsView, our mission is to simplify your shopping experience by providing you with carefully curated product recommendations across a wide range of categories. However, despite these limitations, our data clearly demonstrates the unrealistic expectations that are stated online for the role of vitamins and antioxidants in male infertility. This study also only utilized a single search term (“Testosterone Booster”). Limitations of our study are that we used only Google as our search engine, and there may be regional and geographic differences in search engine results. All supplements were queried using the proprietary ReviewMeta service as detailed in the methods to analyze maliciousreview trends and eliminate untrustworthy comments. All reviews from thetop 2 pages of comments were collected for each supplement, resulting in a total of 65 reviews, and analyzed using the ADAMquestionnaire as described in methods. Among the 37 human studies, 30% (11/37) observed an increase in T levels, 3% (1/37) a decrease, 46% (17/37) no effect and22% (8/37) were indeterminate. There are a couple of reasons men may experience decline in testosterone levels. We've all heard of the male hormone testosterone, but did you know that it supports a man's mood, weight, muscle, and even his sexual health? Men need testosterone to build muscle and maintain sexual health, but levels decline over time. This supports our claim that many of the reviews touting benefits of certain T-Boosters may be false or artificiallymanufactured. And research shows that testosterone levels in American men are steadily declining due to modern lifestyle habits and birth cohort differences. “Many supplements on the market merely contain vitamins and minerals, but don’t do anything to improve testosterone,” Samplaski said. Then, the team reviewed published scientific literature on testosterone and the 109 components found in the supplements. "Many supplements on the market merely contain vitamins and minerals, but don't do anything to improve testosterone," says Samplaski. Furthermore, all of these supplements were marketed as being produced in ‘FDA Registered Facilities.’ Patientsshould be counseled that the FDA does not formally review and approve supplements in the U.S., and therefore such claims should beviewed with caution. This raises questions as to the authenticity of both on-bottle marketing as well as reviews touting the benefits of theseproducts. Mintzes supported these conclusions by drawing attention to howpharmaceutical brands employ techniques such as ghostwriting or fake reviews to disingenuously promote testosterone boosting therapies. Researchers performed a Google search with the search term “Testosterone Booster,” thus mimicking a typical internet research for someone looking to increase testosterone levels, and then selected the first 50 products that came up in their search. Due to the growing interest in herbal ingredients and other dietary supplements worldwide, the use of testosterone boosters is becoming more and more mainstream among athletes, but several side effects were documented. Patients should be informed that “T booster” supplements may not have ingredients to support their claims. Thesignificance of these fake product reviews is heightened by the fact that patients place high levels of trust in health-relatedinformation displayed online. Patients should be informed that "T booster" supplements may not have ingredients to support their claims. A total of 10.1% contained components with data suggesting a negative effect on T. Supplements contained a median 1,291% of the RDA for vitamin B12, 807.6% for vitamin B6, 272% of zinc, 200% of vitamin B5, and 187.5% of vitamin B3. One-hundred nine unique components were found, with a mean number of 8.3 per product. Whether you are a beginner or an elite athlete, we are here to support your goals with trustworthy and up-to-date information in strength, fitness, and nutrition. Our review revealed that only limited, flawed human studies have evaluated efficacy ofsome of the most common ingredients in these supplements, with no definitive findings. Despitethe small sample size of this study, we believe our selection of the top 5 supplements is appropriate given that customers often donot browse past the first few products. As such,patients should be informed that several of the studies we encountered did not formally examine testosterone levels but ratherutilized corollaries of improvement in serum testosterone levels such as subjective improvements in libido or strength. Even among these human studies, most ingredients were either indeterminate orineffective at actually raising testosterone levels. While the problem ofcontamination is not exclusive to T-Boosters, the use of these products among competitive athletes who routinely undergo testing forbanned substances underscores the need for transparency in labeling the full spectrum of ingredients found in these supplements36,39,40. These products are recommended based on your quiz answers. This means that if you click on certain links to products and make a purchase, we may earn a small commission at no extra cost to you. This section collects any data citations, data availability statements, or supplementary materials included in this article. De Frietas et al. found that pharmaceutical companies leverage online consumption dynamicsto increase consumer awareness and desire for healthcare products. A total of 13,806 reviews existed among the 5 productsand of these, 66.6% were considered to be untrustworthy using ReviewMeta filtration and excluded from analysis. Supplement information, ingredients,and comments from the initial 2 available pages of reviews were collected and stored offline to ensure consistency in dataanalysis given the dynamic and routinely updated online marketplace. As a result,customers buying products, including T-Boosters, often utilize user reviews to inform and validate product efficacy. Social commerce encourages consumers to comment, share and “promote” products via online reviews. Certainly, it is not a substitute for a healthy lifestyle, which is what many of the claims seem to tout. It is important that patients have a realistic picture of what to expect with T supplementation. While TRT may have these effects, the FDA states that “Unlike drugs, supplements are not intended to treat, diagnose, prevent, or cure diseases. Zinc, fenugreek extract and vitamin B6 were three of the most common components in the supplements. The present case provided weak evidence of causality between acute liver injury and a commercial testosterone booster. Overall, the evidence was inconclusive in the present work in terms of linking the use of a testosterone booster with liver injury. The medical complications observed were found to have occurred following the consumption of two courses of a commercial testosterone booster. Foods containing such substances are known as testosterone-foods; and they tend to be rich in vitamins, antioxidants, and minerals like zinc, which plays a key role in testosterone production.2,6-8 The blood tests and reports suggested that the commercial product consumed might negatively affect several hepatic functions and resulted in slightly increased testosterone concentrations after the fourth course. He admitted to having consumed two courses of a testosterone booster over a period of 42 days following the instructions of the manufacturer. Stress reduction and enhanced physical capability are directly linked to testosterone levels, ensuring you’re not just surviving but thriving in daily life.Premium Quality – Crafted in the USA within a GMP-certified facility, our Testosterone Booster undergoes stringent third-party lab testing for purity and potency. Tribulus supports libido and muscle strength. If you are planning to become pregnant, are pregnant, nursing, have any medical conditions, or are on any medications, please consult your healthcare provider before use. Please note that during theproduction process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journalpertain. The manuscript will undergo copyediting,typesetting, and review of the resulting proof before it is published in its final citable form. The natural formula includes Ashwagandha, Tongkat Ali, and other vitamins. It’s also non-GMO and vegan-friendly, ensuring you choose a product that’s both effective and ethically made. Hormonal balance is key for maintaining energy, mood, and intimate wellness, directly impacting your daily performance and long-term health.Herbal Powerhouse for Vitality – Ginseng and Rhodiola are included for their adaptogenic properties, reducing stress and enhancing physical performance. The ReviewMeta algorithm also assigns a scoreof Pass, Warn or Fail under each of the 11 domains to provide more insight into patterns underlying suspicious reviews. A proprietary web-based online review analyzing service, ReviewMeta, was used to analyze the integrity of review commentsfor each supplement. The AndrogenDeficiency in the Aging Male (ADAM) questionnaire (Supplementary Figure1), a validated tool for identifying and classifying hypogonadal symptoms, and assessing response to T boosting therapies,was employed to analyze reviews for T boosting efficacy. Hypogonadism is a clinical syndrome that is characterized by low serum testosterone (T) levels and the presence of symptomsincluding low libido, fatigue and sexual dysfunction, among others1–3. The US Food and Drug Administration (FDA) clearly states that, “Unlike drugs, supplements are not intended to treat, diagnose, prevent, or cure diseases.Thirteen products exceeded the US Food and Drug Administration UL of ingredients (zinc, vitamin B3, and magnesium).And all contain herbs, minerals, and natural ingredients which are generally safe.Patients should be informed that “T booster” supplements may not have components with mechanisms to support their claims.Testosterone production is reduced gradually in men starting from the age of 30.A physical examination that included blood pressure and pulse assessments showed nothing out of the ordinary, and the man appeared to be in good condition before product consumption.The reasons for this are unknown, but some of these men may be seeking alternative treatments, such as care at rejuvenation centers or using over the counter T supplements.There are a couple of reasons men may experience decline in testosterone levels.Bucked Up RUT is a quality product from an awesome company and it’s got some great ingredients to support your testosterone. Another study looking at the effect of red clover on the quality of life, and sexual function in men found that this supplement did not change sexual or erectile function, and resulted in a significant increase in liver transaminases . There is often the hope that supplements will increase T in a more “natural” manner, and therefore be free from risk. Herbal supplements designed to increase T are poorly studied yet remain popular among aging men who seek to increase their T without standard TRT. Three of the 5 T-Boosters did not report quantities of individual ingredients, but rather onlyprovided a list of all ingredients. The number of failed categories for eachsupplement was correlated to the percentage of eliminated untrustworthy comments using Pearson correlation. Bias was further mitigated by using browser-based private modefeatures for all online data acquisition. The dangers of these marketing myths are evidenced by a string ofrecent case reports highlighting adverse reactions following T-Booster use among impressionable populations, including adolescents andhealth enthusiasts11–13. E-commerce is an increasingly popular option for consumers in researching and purchasing products14,16. The more “fail” resultsthat a supplement had, the more likely that it had questionable reviews. As previously described, the algorithm utilizes 11 categories, such asunverified purchases, incentivized reviews, and phrase repetitions and determines whether reviews of a product“pass,” “warn” or “fail” under each domain. However, one study found that 87.8% men with low T were not receiving treatment, despite adequate access to care . Testosterone replacement therapy (TRT) is a well-established option for those with symptomatic hypogonadism related to low T levels. It is estimated that men in their 70s have mean T levels 35% lower than younger men . A progressive decline in testosterone (T) is seen with male aging, estimated at 0.4% to 2.0% decline per year after age 30 . Internet Explorer is no longer supported by many websites. The FDA does not issue RDA and upper tolerable limit data for herbal supplements. It is unclear why companies would include components in their supplements that have no evidence to support their use. Only 5.5% of supplements had more than two studies looking at their effect on T. That means supplements should not make claims, such as “reduces pain” or “treats heart disease”. These over the counter “T boosters” are often taken with the hopes of raising endogenous T production and doing this in a more “natural” manner. Approximately 50% of American adults consume dietary supplements to promote overall health and fill dietary gaps 4,5. PubMed was reviewed for any literature supporting the claims, followed by review of Recommended Daily Allowance (RDA) and upper tolerable intake level (UL) for each component. We do not verify or endorse any claims made in these reviews. Blend of 17 ingredients to facilitate Energy levels, better body health and muscle support. Research Labs Testosterone Booster well researched ingredients to help to increase testosterone in men, increase muscle, energy, strength, libido. Test Boost Advanced is another quality product with many ingredients that support testosterone. However, for many of these (15 of the 27, or 55.5%) there was also conflicting data showing no change or a decrease in T with supplementation. While not specified in the FDA warning, this potential risk may extend to herbal T supplements as well. Illustrating this, a 2017 case report described new-onset, bilateral pulmonary embolisms secondary to over-the-counter fenugreek-extract-containing T supplements . These products are often poorly regulated and minimally studied, both in terms of efficacy and toxicity profile. Interestingly, the supplements contained a mean 3.1% of the RDA of calcium. Testosterone boosters come in different forms but the base ingredients are often similar. Here’s the thing… there isn’t one best testosterone booster on the market. Testosterone levels decrease due to many reasons and almost 40% of men over age 45 are affected by low testosterone levels. So, it’s an important herb in test booster products.