Intermittent fasting allows your organs to rest, especially your liver, which is so crucial for naturally balancing hormones, especially testosterone. An unexpected natural way to increase testosterone is intermittent fasting. Meanwhile, two other supplements that appear to assist with improved strength, fat burning, muscle building and/or energy are turkesterone and ecdysterone. In an Iranian study, 30 healthy non-athlete males were randomly divided into placebo and glutamine supplementation groups and put through the same three days a week eight-week resistance training program. A study linked TRT to higher chances of venous thromboembolism, a potentially fatal type of blood clot. In 2014, the FDA ordered that a warning label must accompany TRT prescriptions, alerting men to the possibility that TRT increases the chances of heart attack and stroke. Eventually, that drop could lead to hypogonadism, or low testosterone. The number of men who take testosterone has dropped dramatically in the past few years, in part because of growing awareness of the risks that may accompany it. Additionally, maintaining a healthy weight and avoiding excessive alcohol and tobacco use can further support healthy testosterone levels. Engaging in regular physical activity has been shown to increase testosterone production naturally. Certain foods are known to boost testosterone levels naturally due to their nutrient content. They contain ingredients like D-aspartic acid, which might stimulate the release of hormones responsible for testosterone production. Even among these human studies, most ingredients were either indeterminate orineffective at actually raising testosterone levels. A review of the literature supporting T-Boosters underscores the paucity of data available on the impact of T-Boosteringredients on serum testosterone levels. Testosterone boosters are heavily marketed on social media and marketplaces to men with claims to significantly increase testosterone. Unfortunately, studies have shown that most libido enhancers do not cause an increase in testosterone levels. Testosterone boosters are herbal supplements. The study found that the higher the subjects went in total protein intake, the lower their testosterone was (28). One study showed that men who ate a high protein diet for 10 days had 36% less free testosterone than their normal protein counterparts (27). Research shows that people who consume 30 milligrams of zinc a day increase the free testosterone in their bodies (20). That means you want to find ways to naturally relieve stress to keep your testosterone levels up. The results concluded that even moderate weight lifting and light weightlifting increased serum testosterone levels in participants. If you want to naturally boost testosterone and human growth hormone (HGH), then combine weight training with HIIT workouts (high-intensity interval training). Limitations of our study are that we used only Google as our search engine, and there may be regional and geographic differences in search engine results. Certainly, it is not a substitute for a healthy lifestyle, which is what many of the claims seem to tout. It is important that patients have a realistic picture of what to expect with T supplementation. Supplements contained a median 1,291% of the RDA for vitamin B12, 807.6% of vitamin B6, 272% of zinc, 200% of vitamin B5, and 187.5% of vitamin B3 (Table 4). We administered two different growth hormone-releasing hormones (GHRH) to 20 short, prepubertal children who had spontaneous secretion of growth hormone (GH), assessed from 24-hour GH secretion profiles (72 sampling periods of 20 min). Sermorelin acetate, also simply known as sermorelin, is a growth hormone-releasing hormone (GHRH) that’s commonly used as a treatment in children with growth hormone deficiency. Human chorionic gonadotropin (hCG) is a naturally occurring protein produced by the human placenta with a serum half-life of approximately 36 h. Gonadorelin, or gonadorelin acetate,is a synthetic peptide produced in a region of the brain that mimics natural GnRH. A PubMed analysis as detailed in the methods was undertaken for the 10 most common ingredients used across all supplementsand is presented in Table 2. A total of 19 unique ingredients were identified across the group of supplements; eachsupplement consisted of an average of 9.8 ± 2.2 ingredients (Range 7-12). Supplement ingredients were aggregated and catalogued for each supplement, and the 10 most frequently utilized ingredientsacross the set of supplements were identified. Thesignificance of these fake product reviews is heightened by the fact that patients place high levels of trust in health-relatedinformation displayed online. NEGATIVE EFFECTS OF LOW TESTOSTERONE Steroids are synthetic versions of hormones that are designed to directly increase testosterone levels in your body. “However, evidence does not suggest that vitamin D supplementation increases normal-range testosterone levels in men.” It is important to know that while studies suggest ashwagandha may help increase testosterone levels, additional research is needed to confirm these effects and to recommend the optimal dosage. If you are a transmasculine athlete, these testosterone boosters are not designed with your specific needs in mind. My stress-filled August was likely another factor leading to my low T levels.That’s a significant blow to the product's potential efficacy.In this way, such supplements can act as fat burners, male vitality pills, and even pre-workouts.It also regulates cortisol levels, reducing stress and improving mood and mental health.Yes, but you must look on independent platforms like Trustpilot, not the product's official website. Supplement With Zinc Aging 10 years increases your odds of having low testosterone by 36%, but a 4-inch increase in waist size may increase your chances by up to 75%. Talk to your doctor before you try any supplements to make sure they won't interact with your other medications. Also, some supplements aren't safe to take with some prescription drugs. That means there's no guarantee of how powerful the active ingredients are or if the products even contain what they say they do. A main concern with supplements is that they aren't regulated by the FDA the same way drugs are. Innerbody Labs chose these ingredients based on the quality and quantity of available research supporting their efficacy in raising testosterone levels. The top supplements in this guide may have certain ingredients that pose some risks, such as ashwagandha’s potential influence over thyroid hormone levels.16 But those risks are either extrapolated from related data or currently only exist as case studies. There’s also an opportunity in testosterone-boosting supplements to add ingredients that can account for the potential adverse effects of others. While TRT may have these effects, the FDA states that “Unlike drugs, supplements are not intended to treat, diagnose, prevent, or cure diseases. RDA information was not available for many of the individual components for the “T boosters”. It is unclear why companies would include components in their supplements that have no evidence to support their use. For 24.8%, or 27 out of 109 individual supplements, there was data showing an increase in T with supplementation. And an increased risk of heart She is passionate about empowering people to live a healthy lifestyle and promoting the benefits of a plant-based diet. She is a certified personal trainer, nutritionist and health coach with nearly 10 years of professional experience. It’s overseen by a doctor and endocrinologist, and that is the safest way to alter your gender-related hormone levels. That said, we’re not here to dampen your curiosity about questions like, “Does creatine increase testosterone? He is the author of “Hold On to Your Muscle, Be Free of Disease,” a unique approach to health improvement and anti-aging in the context of muscle health. Robert Iafelice is a nutritionist, registered dietitian, and supplements expert. Although endurance activities are a good form of exercise and excellent for your heart health, too much endurance harms testosterone.The amount of time it takes to recover testosterone to healthy levels depends on how low your levels are and your course of action.An added testosterone benefit of my high fat and balanced protein and carb diet was that it probably helped me lose some body fat (I went from 18% to 12% body fat).Hypogonadism is a clinical syndrome that is characterized by low serum testosterone (T) levels and the presence of symptomsincluding low libido, fatigue and sexual dysfunction, among others1–3.Testosterone is the major sex hormone in males.Individuals with poor stress management skills and unstable social relationships may experience more fluctuations in their testosterone levels. This therapy improved semen parameters and serum gonadotropin and testosterone levels. In women, this helps boost egg production in the ovaries, assisting with regular ovulation while increasing the chance of getting pregnant. Kisspeptin, a peptide produced by the hypothalamus in the brain, plays an important role in human reproduction and sex drive, cognitive function, bone health, and fat distribution. About the Reviewer Roman also sends you its product in a refillable glass jar, and subsequent orders arrive in recyclable pouches. We wish it would keep the testosterone test on its site regardless of availability. Roman sometimes offers testosterone testing as part of its available services, making it a one-stop shop for men who want to get a diagnosis and treatment for their low testosterone. It has grown into a telehealth juggernaut over the years whose range of offerings includes hair loss treatments, erectile dysfunction (ED) treatments, and weight loss services. If a company doesn't use clinically relevant doses, it had better employ a combination of ingredients that can make up the difference. All ingredients in Ritual’s multivitamins are sourced from plant-based sources, making them suitable for men with various dietary preferences and lifestyles. In addition to vitamin D3, Ritual’s multivitamin incorporates other essential vitamins and minerals, such as zinc, magnesium, and boron, which play significant roles in testosterone synthesis. Moreover, research28 indicates that vitamin D3 is more effective at raising blood levels of vitamin D than vitamin D2. Although there are no specific dosage recommendations for increasing testosterone, the daily tolerable limit for vitamin D27 is 100 micrograms (4,000 IU) per day. Strengths/Limitations: Innerbody uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. If your testosterone levels are too low, it's possible that Viagra and similar prescription ED medications might not work. If your test results show testosterone levels below the normal range or your symptoms are significant, you should seek treatment beyond simple dietary adjustments. Battle Balm® Review ( : The Secret Weapon Against Pain Michael Eisenberg, MD, director, Stanford Male Reproductive Medicine and Surgery Program, Stanford Health Care, Palo Alto, CA. Could something other than low testosterone explain my symptoms? But Eisenberg stresses that men with very low testosterone have a higher chance of developing heart disease, osteoporosis, and other problems if they go untreated. Eisenberg says that studies of TRT’s benefits and risks have had mixed results and provide limited answers. Another concern is whether TRT actually improves symptoms linked to low testosterone. Testosterone is the main male sex hormone crucial for fertility, muscle development, bone density, libido, and mood. Check with them before you try supplements, both for safety and to make sure you'll get the results you're looking for. It's important for your sex drive, bone and muscle health, energy, and mood. Increased cortisol levels can also cause you to overeat, which can contribute to weight gain and lowered testosterone. Cortisol is a hormone that works against your testosterone. Although testosterone may make prostate cancer grow, it is not clear that testosterone treatment actually causes cancer. Men taking testosterone replacement must be carefully monitored for prostate cancer. There are times when low testosterone is not such a bad thing. As surprising as it may be, women can also be bothered by symptoms of testosterone deficiency. Some men who have a testosterone deficiency have symptoms or conditions related to their low testosterone that will improve when they take testosterone replacement. Best Testosterone Booster For Muscle Growth: Prime Male These claims may sound impressive, but in many cases there isn’t enough scientific evidence to support them. We may earn commission from links on this page, but we only recommend products we back. (And if you wonder what it's really like to take testosterone, three guys under age 50 talk about it here.) Which is to say that for low T, a supplement shouldn’t be what you turn to. All of these have no role in improving testosterone,” he says. One 30-serving bottle of this product costs $59.99, which is about $1.99 per serving, so we gave the product a 3 out of 5 for cost. Although this product isn’t third-party-tested, we appreciate that it doesn’t include any proprietary blends. “Even though the product claims to be backed by research, it’s outdated and that shows in the doses of each ingredient.” Testogen also contains 40 milligrams of fenugreek extract, which may improve upper- and lower-body strength when taken in high doses. Podcast #1,096: Why You Don’t Follow Through on Your Health Goals — and How to Fix It Anecdotal evidence suggests a link between sulfur and penis enlargement, but extensive study is still missing from the picture. Volume Pills provides the ingredient quantity of its entire proprietary blend per dose, but not for the individual ingredients. Fans of Chinese and Ayurvedic medicine will appreciate the combination of ingredients they'll find in Volume Pills. Who should buy testosterone boosters? Its basic formulation is similar to that of the old-school testosterone booster ZMA, but heavily upgraded with the latest ingredients from nutritional research. While not every top-rated testosterone booster needed to include all of these, including at least some of them indicated that the supplement designers knew what they were doing. While a testosterone booster won’t solve all of these problems all by itself, it could help you get over the additional challenges of the negative effects of low testosterone. Foggy memory, fatigue, listlessness, and low energy levels are often linked to decreased testosterone in men, so you don’t need to be trying for a personal best in the bench press to opt for a testosterone booster. The present study is descriptive in nature, without direct patient or subject involvement, using commercially available online information on over-the-counter T supplements. A structured PubMed search was the performed for “testosterone” and each of the 109 components found in the supplements. Other search terms such as “Testosterone Supplement” yielded products that contained exogenous sources of hormone, which is beyond the scope of this study. Approximately 50% of American adults consume dietary supplements to promote overall health and fill dietary gaps 4,5. Testogen is a supplement with a transparent formula and 11 active ingredients. One thing we appreciate most about Transparent Labs products is their exclusion of artificial ingredients and additives. Although DIM may reduce estrogen levels, it also possesses antiandrogen21 properties, which could block or suppress testosterone. A 2022 review19 suggests quercetin may improve male reproductive health. Some people claim fasting boosts testosterone, but it’s not that simple. Prioritize quality sleep, regular exercise, a healthy diet, and manage your stress levels. Some people swear by them, experiencing increased energy, muscle mass, and libido. A balanced diet rich in protein, healthy fats, and nutrients like zinc and vitamin D is also crucial. We found ourselves wishing to find a testosterone booster that we could recommend more full-throatedly — an affordable supplement that contains clinically relevant doses of ingredients that all carry scientific backing for testosterone enhancement. Plus, this testosterone booster ships beyond just the U.S., U.K., and Canada, making it a viable alternative for people in those countries who can’t access products from Innerbody Labs. Our team has researched the top supplements in the field to determine which testosterone booster is likely the best for you. A natural testosterone booster is one comprised of natural ingredients, rather than artificial fillers or synthetic compositions. Hypogonadism is a clinical syndrome that is characterized by low serum testosterone (T) levels and the presence of symptomsincluding low libido, fatigue and sexual dysfunction, among others1–3. Nineteen unique ingredients were identified across these T-Boosters, and literature review revealed 191 studiesinvolving the 10 most common ingredients, of which 19% involved human subjects, 53% animal models, 15% invitro studies and 12% case reports or review articles. The author would like to acknowledge the support from the other members of the Young Academic Urologist (YAU) Male Sexual and Reproductive Health group who are not cited as authors. The data that support the findings of this study are available from the corresponding author, AM, upon reasonable request. Our findings indicate that most fail to increase total testosterone. You also get 15 milligrams of zinc, a mineral that’s directly correlated with testosterone levels, according to studies. Case and point, they use 100 milligrams of Long Jack Extract, which might seem small but studies have suggested that dose is beneficial in “enhancing testosterone production. Testogen is a testosterone booster that makes bold claims, including energy, mood, focus, and vitality improvements in as little as two weeks. Transparent Labs stands out for its transparently formulated supplements, and its natural Vitality product aligns with this unwavering commitment. One of the best is Testofuel, which contains everything your body needs to push natural testosterone production to the max. Getting into a healthy weight range is arguably the most important factor you have control over for naturally optimizing your testosterone levels. It’s no surprise that being overweight has negative consequences on your body’s ability to support high testosterone levels (1). When testosterone levels rise too high, the brain sends signals to the pituitary to reduce production. Men with optimal testosterone levels can reach their peak shape and performance even after turning 40. This gives them much faster muscle growth and recovery, leading to increased muscle mass and a bodybuilder's physique. High free testosterone hormone levels allow men to stay youthful and energetic well into middle age. It helps make users more muscular and shredded, all thanks to optimal testosterone levels. Every doctor we talked to was skeptical about supplements. Please note that during theproduction process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journalpertain. First, this analysis was limited to 5 T-Boostingsupplements that were identified as the top hits on a single search. Understandingpatients’ overall satisfaction with these products can enable healthcare providers to target future counseling efforts. According to a review published in the Biomolecules journal, there’s a possibility that ginger extracts may also increase testosterone levels. As such, there is no evidence that this ingredient can directly boost testosterone production. According to a review published in the Experimental Gerontology journal, DHEA may help increase testosterone levels. Androstenedione is a weak anabolic steroid used to boost testosterone levels. Also, Rise may re-energize users with a sense of youthful vitality and boost confidence. Its unique mix of ingredients, backed by research, is designed to enhance gym performance. D-Bal Max is notable for its nutrient-rich formula, which speeds up muscle recovery and growth. We appreciate that TestoPrime lists clinical studies at the bottom of its main page. Instead, TestoPrime’s zinc, ashwagandha, and vitamin D quantities are more indicative of its potential. In so doing, we’re able to deliver what we feel to be more effective doses of the more promising ingredients while keeping the final cost lower for you. Our supplement provides relevant doses of every key ingredient. It’s been shown to decrease plasma testosterone levels, and be harmful to male reproductive health (21, 22). One article published in 2011 found that both athletes and sedentary individuals can increase their testosterone levels with magnesium supplementation (18). Another 2017 study examined the effects HIIT training had on male athletes and concluded it to increase free testosterone and muscle power (14). In other words, if your body is lacking energy, the last thing on its mind is increasing its testosterone production for good sexual health. TRT typically involves delivering exogenous testosterone to your system, either through injection or transdermal means like a patch or topical cream. However, they can be much more dangerous than other methods, with side effects that include hormonal imbalances resulting in aggression, acne, mania, and infertility.25 They’re often a last resort for men who’ve been unsuccessful with other treatments or those whose T levels are low enough to warrant specialized treatment. At this time, the only reasons you might prefer Test Boost Max are that it includes Tribulus terrestris — which you'll rarely see in a Nugenix supplement — and that it costs a lot less. Another study involving wrestlers showed an improvement in serum testosterone levels after losing weight (3). For men with low blood testosterone levels and symptoms most likely caused by a low level, the benefits of hormone replacement therapy usually outweigh potential risks. Estrogen therapy increases sex hormone binding globulin and, like aging men, this reduces the amount of free, active testosterone in the body. Both raise levels of a hormone that triggers your body to make testosterone. The most common price for a bottle of natural testosterone boosters is between $59.99 and $69.99. On average, testosterone booster supplements can quickly elevate your energy levels, with physical changes starting about a month after use. Dietary supplements that give men healthy testosterone levels can have unwanted side effects when combined with medications. Having said that, many of the natural testosterone boosters are designed to be taken in the morning before breakfast or as two pills in the morning and evening. Fenugreek is one of the most powerful herbal testosterone boosters with strong scientific evidence.(5) Fenugreek also boosts libido, improves sperm health, and produces stronger erections. Testosterone boosters are generally natural supplements that increase testosterone and testosterone-related hormones in your body.It has additional products for hair loss, sexual health, weight loss, and more.Topical testosterone gels and patches can also induce allergic reactions.” or dismiss the exploration of other marketed boosters—there’s always something new to learn, after all; especially if you’re looking for the best supplements for men.Of concern, 10.1% of components had published data that found a decrease in T with supplementation.These authentic voices from real customers expose the truth behind the polished advertising of TestoGreens Max supplements.Women with high testosterone levels, due to either disease or drug use, may experience a decrease in breast size and deepening of the voice, in addition to many of the problems men may have.GHRH 1-29 also induced a short-term, small increase in the concentrations of prolactin (p less than 0.05), luteinizing hormone (p less than 0.01) and follicle-stimulating hormone (p less than 0.05). Testosterone boosters can shut off your natural production and permanently lower your sperm count. If you're hoping that testosterone boosters will treat ED but aren't sure whether you even have low testosterone, you might want to take an at-home testosterone test. The company used a proprietary blend — a practice that other testosterone boosters in this guide refrain from, as it obscures doses. Most testosterone boosters should be completely safe for the majority of users. Take a look at the chart below to see how top testosterone boosters compare. Top Do Any Testosterone Boosters Really Work Related Articles The best types of exercise to increase your testosterone levels are weightlifting and high-intensity interval training (HIIT). However, a subsequent study showed that taking 3 grams of D-aspartic acid did not affect testosterone levels. A recent study found that it may increase levels of follicle-stimulating hormone and luteinizing hormone. In 2014, the FDA ordered that a warning label must accompany TRT prescriptions, alerting men to the possibility that TRT increases the chances of heart attack and stroke.This testing ensures the product has been thoroughly examined for safety and quality.However, for many of these (15 of the 27, or 55.5%) there was also conflicting data showing no change or a decrease in T with supplementation.First, it’s important to note that these tactics and practices to boost testosterone naturally probably won’t work with men who have underlying health issues like hypogonadism.One of the big reasons is because fat cells have a special enzyme called aromatase, which turns testosterone molecules into estrogen.Adequate sleep is vital, as poor sleep might dramatically reduce testosterone levels.Exercise boosts testosterone in two important ways.Throughout this guide, you'll find that we're quick to point out when a different option would be a better choice than our supplement.After filtration, a total of 43, user comments were re-evaluated using the ADAM questionnaire to semi-quantitativelydetermine the effects of individual T-Boosters on quality of life. It stimulates the production of luteinizing hormone, which boosts testosterone synthesis and release. The primary ingredients in Prime Male stimulate natural testosterone production. TestoGen easily clears any doubts as it is an all-natural testosterone booster. It's a premium product with a careful selection of ingredients that support optimal levels of testosterone. They increase the natural production of testosterone, which helps you take your physical and sexual performance to the next level. If your at-home test shows low testosterone or you’re still having symptoms, it’s crucial to follow up with your doctor. If your testosterone is low, there are different treatment options you can discuss with your doctor to get you feeling more like yourself again. This is especially important for individuals considering testosterone therapy or testosterone replacement therapy. There were a mean 8.3 components per supplement (range, 29; median, 7; mode, 6; standard deviation, 5.52; interquartile range, 1–7). Only articles that looked at the effect of supplementation were included. Despite their popularity, the scientific rationale for these products often remains unexplained or unproven. However, one study found that 87.8% men with low T were not receiving treatment, despite adequate access to care . The US Food and Drug Administration (FDA) clearly states that, “Unlike drugs, supplements are not intended to treat, diagnose, prevent, or cure diseases. The reasons for this are unknown, but some of these men may be seeking alternative treatments, such as care at rejuvenation centers or using over the counter T supplements. So if you can't get your vit D from exposure to the sun, consider the benefits of supplements. D-Aspartic acid is a natural amino acid involved in the synthesis and release of testosterone. We've already discussed how a man's T levels will dwindle with age, but you can encourage the body to produce more by making some simple changes to your diet. If you aren’t eating enough calories, your body shuts down its reproductive health to give more vital processes more attention. In fact, long-term calorie restriction is connected to lower testosterone levels (12). Sprinting works your legs and glutes (the largest muscle in the body), and are an amazing explosive exercise to lose weight and increase your speed. Certain foods, like soy and mint, can even decrease your testosterone levels (8, 9). While we appreciate the simplicity of this formula, some athletes may prefer a more robust supplement with additional clinically-backed ingredients. Each serving of TestoPrime consists of 4 capsules, which can feel like a lot if you’re taking other supplements. (8)(30) Plus, our testers love that this product is third-party tested and free of artificial, unwanted ingredients. As a result,customers buying products, including T-Boosters, often utilize user reviews to inform and validate product efficacy. Social commerce encourages consumers to comment, share and “promote” products via online reviews. The dangers of these marketing myths are evidenced by a string ofrecent case reports highlighting adverse reactions following T-Booster use among impressionable populations, including adolescents andhealth enthusiasts11–13. The laxity of FDA supplement regulation is well established, and has enabled T-Boosters to proliferatewithout rigorous quality control, ingredient standardization or verification of touted benefits . 25 Gut Health Hacks is yours absolutely FREE when you sign up to receive health information from Harvard Medical School. Get the latest in health news delivered to your inbox! Here is how to take a cautious approach to testosterone therapy. Although this new information is somewhat reassuring, men and their doctors should still weigh these issues before committing to long term testosterone therapy. “Many supplements on the market merely contain vitamins and minerals, but don’t do anything to improve testosterone,” Samplaski said. Men can often feel a big difference when they stop therapy because their body's testosterone production has not yet recovered. This increased estrogen can trigger a negative feedback loop, suppressing the HPG axis and reducing testosterone levels. MK-677, also known as ibutamoren or ibutamoren mesylate, is a growth hormone secretagogue that increases growth hormone production and insulin-like growth factor 1 (IGF-1). Following just 5 days of treatment, men who received GHRP-2 alongside TRH and GnRH experienced an impressive 80% increase in testosterone levels from day 1 to day 3. A reasonable price point combined with a solid money-back guarantee signaled a manufacturer’s confidence in their product, giving us and potential users peace of mind.Roman also sends you its product in a refillable glass jar, and subsequent orders arrive in recyclable pouches.The good news here is that while the things I recommend below will boost your T, their effect is hardly limited to testosterone.The natural high quality of this supplement makes it a favored amongst customers as well as a suggested product by physicians.These real reviews are overwhelmingly negative and consistently warn that the product is a scam, ineffective, and comes with fraudulent billing issues.Because TestRX increases testosterone, people who use it can have a faster metabolism and burn fat more efficiently. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. This product is not intended to diagnose, treat, cure, or prevent any diseases. For instance, fenugreek may interact with antidiabetic medications, potentially lowering blood sugar levels to a dangerous range. So, was it the supplement or merely the focus on nutrition, sleep, and exercise? What we have to be mindful of are all the other lifestyle optimization interventions one will go through while taking a mixed supplement. With such a complex combination of ingredients, there are many ancillary benefits. Bioperine® is one such ingredient and has the ability to increase the bioavailability of nutritional compounds. As a rough rule, levels in men generally start to decline around the age of 30.