Strategies to limit counterfeiting should be multi-faceted and target prescribing healthcare professionals, pharmaceutical companies, regulatory authorities, and patients. However, by doing so, many of these patients are unknowingly subjecting themselves to significant health dangers. Even though 57 of 58 products were labeled as “all natural” and no sample claimed to include synthetic substances, 81% contained PDE-5i. The common link between these patients was the use of an ED supplement that contained glyburide (a sulfonylurea used to treat diabetes), as well as illicit PDE-5i (31). In response to treatment, serum follicle-stimulating hormone decreased but serum testosterone and Inhibin B increased. Safarinejad et al investigated the effect of selenium and N-acetyl-cysteine on 468 infertile men with idiopathic oligo-asthenoteratospermia. N-acetyl cysteine is a naturally occurring compound which comes from amino acid L-cysteine, and functionsas a precursor of glutathione peroxidase (53). A total of 37 fertile male and 37 infertile men that have been adjusted for age, received 2 zinc sulphate capsules (220 mg per capsule) per day for 3 months. Testosterone boosters' appeal over Testosterone Therapy and steroids is that they increase testosterone levels naturally.On this regard, weight excess and other conditions such as metabolic syndrome, alcohol abuse, cigarette smoking, exposure to environmental pollutants etc. have been strongly related to a decrease in sperm quality and fertility.At approximately $70/month, it is a bit pricey, but still much more affordable than other premium male fertility supplements.It is necessary to inform the public about the risk of sexual enhancement supplement use and also prepare a place for consultation on media channels that younger people are more familiar with, in order to monitor adverse events while also preserving their privacy.A testosterone booster might help, but you should get your testosterone checked by a doctor to see if you need a prescription medication to fix the problem.We are proud to offer Titan Transform, crafted with all-natural, non-GMO, and gluten-free ingredients.TestoPrime prides itself on turning back the male biological clock.This can include products with bona fide ingredients, but with insufficient or excessive quantities, products with the wrong ingredients, or products with deceptive packaging.Supplements that support stamina and focus help bring this confidence to life. What Are the Different Types of Testosterone Booster and Male Enhancement Pills? In Japan, although adulterated supplement products are mainly found overseas, the current media channels provide us with easy access to purchase these products. Of these users, 68% did so without a prescription, as patients often do not realize that they are getting false and possibly dangerous products, and 60% of these users believed they received the same product as from a legitimate pharmacy (13). Ultimately, focusing on a holistic approach to overall health, including diet, exercise, and stress management, is key to achieving optimal sexual function and wellness. When considering herbal remedies and supplements, prioritizing safety and quality is paramount. Consulting with a healthcare professional before incorporating any new supplement into your routine is essential to ensure safety and appropriateness. The effects of widely variable amounts of active ingredient range from low efficacy at a minimum to severe side effects and negative drug interactions at the worst. Quantities of active ingredients are also highly variable, as seen in Table 2. Furthermore, 11.5% of patients being evaluated for a PDE-5i prescription had a new underlying disease detected (26). In an analysis of 24,708 patients receiving a PDE-5i, 70% had an underlying medical diagnosis, with 50% of these patients having vasculogenic disease. The Second Princeton Consensus on sexual dysfunction and cardiac risk stated that all men with ED, even in the absence of manifesting cardiac symptoms should be regarded as having potential risks for cardiovascular disease (24). Strict guideline and regulations for erectile dysfunction supplements should be implemented to prevent misuse of medications such as Sildenafil or Tadalafil or medications similar in structure. Concrete steps must be taken to improve the safety and well-being of consumers and to decrease the health related consequences from those products which should only be taken under the advice of a physician. Since these supplements are not regulated by the FDA consumers and vendors considered it safe until proven otherwise. Price Some supplement prices increase dramatically as you get into targeted symptom support. Clinically informed formulas offer evidence-based support, reducing the risk of adverse effects and ensuring that the product delivers measurable benefits. With the abundance of supplements on the market, there are a few factors to consider when choosing the right one for you. “It helps the body make quick energy, which supports muscle growth, strength, and faster recovery, making it a great choice for active men. In recent years, the role of this vitamin-like antioxidant in male infertility has been discussed widely. L-carnitine (LC) or 3-aminobutyric acid is a naturally occurring compound and also a semi-essential vitamin like substance required for human metabolism. Results from intra-cytoplasmic sperm injection (ICSI) and IVF show that high levels of sperm DNA damage results in lower fertility rate or infertility. Liquid supplements contain the same ingredients found in the tablets. Choosing sexual enhancement tablets is a rough task because there are so many different types of products sold under this name. Manufacturers advertise that the ingredients in their honey packs can boost sex drive, strengthen erections, raise testosterone (the primary male sex hormone), and improve stamina. A total of 41 different active ingredients were used by manufacturers for the various formulations of DSs. Level C was assigned if multiple RCTs showed opposing results for the same outcome, and level D was given for ingredients showing negative or no effect on the analyzed outcomes. The selected articles allowed us to clearly identify effective ingredients (EIs), namely, the substances proposed as having a clinically demonstrated efficacy on the improvement of erectile function. For the mean difference approach, the standard deviations were used together with the sample sizes to compute the weight given to each study. We research ALL the products so you don’t have to. We don’t see products on this website, so we can tell you the facts without fear of retaliation from the huge companies or advertisers. We help show you which brands use high quality ingredients which are proven to work as advertised. There are many products that will give you very good results – but keep in mind that no product will work miracles, and even the most effective products take some time to work. Certain nutritional supplements may support or fill nutrient gaps and help combat age-related effects and promote healthy aging. In 2026, wellness trends emphasize preventive health and personalized nutrition, prompting shoppers to explore over‑the‑counter options such as the best male enhancement supplement at GNC. Within this context, several male enhancement products for humans are marketed without the alkaloid yohimbe, which has been linked to cardiovascular side effects in some individuals. Male sexual enhancement supplements may not be safe for everyone as they can cause side effects, allergic reactions and interactions with other medications. The market for men’s sexual health supplements is growing as many men turn to them to tackle sexual issues. One study that gave men shilajit for 90 days and found a significant increase in a few key sperm measurements. It is a tar-like substance high in fulvic and humic acids and is reported to have several benefits as a male fertility supplement. Other studies have shown similar results with the primary effect being an increase in sperm count. It is typical for older men to have a lower interest or desire for sexual activity. High-quality male enhancers aim to help by improving the blood flow to the penis. Poor erection is an indication of poor blood circulation to the male organ. However, we recommend consulting your healthcare provider if you have medical conditions or take prescription medications. Its blend of powerful adaptogens helps calm the body, reduce stress, and enhance restful sleep, which in turn minimizes fatigue and supports recovery. “What I love most about Men’s Growth is that it’s completely natural. Made from a potent blend of herbal extracts, essential minerals, and plant-based compounds, it works with your body’s natural processes to promote hormonal balance, improve stamina, and boost confidence—without relying on synthetic chemicals or harmful stimulants. The adverse events experienced may be due to misuse of supplements such as over-use and concomitant use with other supplements. The data presented here were all self-reported; thus, symptoms of adverse events and causal relations to supplements were not medically examined, and the involvement of other foods, drugs, or diseases is unclear. Consumers often confuse supplements with drugs due to their similar forms; thus, they may not have perceived a difference between supplements and drugs. Approximately half of female supplement users used them for weight loss purposes currently or previously.Nitric oxide supplements in particular can increase blood flow and improve sexual function in men.The liquid products have the same benefits as the tablets and capsules.Low testosterone affects 40% of men over 45, per 2025 research, impacting testosterone support supplements.Active ingredients with evidence of efficacy, references, evaluated sperm parameters, employed daily doses and minimal effective dose (mED).Pure Encapsulations Magnesium Glycinate is our pick for the best magnesium supplement, and Dr. Young agrees.However, two other studies showed a significant improvement in zinc-attached ligands and semen key enzymes after zinc therapy (44, 50).Many male fertility supplements focus on antioxidant protection and mitochondrial energy support because sperm are vulnerable to oxidative stress and require energy for motility. Whether it’s a decline in energy at the gym or a shift in intimate confidence, these changes often stem from the body’s natural reduction in testosterone levels. Does zinc supplementation affect sexual performance in men with normal zinc levels? Improving your sexual health doesn’t always require medication or supplements. Doctors may recommend supplements in specific situations where patients are not getting enough nutrients from their diet or have a certain health condition. Titan Transform Customer Reviews Currently, multi-antioxidant supplementa-tions are considered as an effective therapy for male infertility. Placebo controlled clinical trial carried out in Iran and Tunisia showed that selenium supplementation improved sperm counts, concentration, motility and morphology as well as sperm concentration in infertile men (54, 55). Selenium is an essential trace element in formation of sperm and testosterone biosynthesis (52). Peroxynitrite levels, arginase activity and NO synthase activity of the infertile patients were restored to normal values after treatment with zinc sulfate (46). They concluded that peroxynitrite levels and NO synthase activity were significantly higher in the infertile patients compared to the fertile group. The third group of male patients undergoes cosmetic penile contour surgery and repair for congenital and acquired causes of penile damage.22,26,32 These men seek various enlargement methods to increase the size and girth of their penises. Even males with average-sized penises wished to have larger penises, with studies revealing that males are often dissatisfied with their penile look, which is correlated with the frequency they overestimate their penis size. At approximately $70/month, it is a bit pricey, but still much more affordable than other premium male fertility supplements. A number of other studies have also shown selenium to play an important role in sperm health. Male enhancement generally refers to improving aspects of male vitality such as stamina, energy levels, confidence, and overall well-being.Vitamin E has antioxidant roles in reproductive health, and oxidative stress is implicated in fertilization and implantation pathways.This supports muscle building supplements.Moreover, a 2024 study found zinc boosts energy by 25%.By reviewing published research, clinical trials, and scientific literature, we verified the effectiveness of each ingredient in testosterone booster and male enhancement pills.If you’re a man and you want to take better care of your health, several different kinds of supplements can help you along the way.The authors noted that both HA and PLA fillers had significantly enhanced effects in patients with micro penile syndrome 24 weeks after HA and PLA injections, and encephalitis was a severe side effect without serious adverse effects.Muscle building is kind of one thing, but enhancement of exercise performance is a little different. Table 2. Analysis of phosphodiesterase-5 inhibitors (PDE-5i) purchased from the Internet. Despite the potential for millions of sperm to finish their development and be ready for ejaculation each day, each of those sperm started their developmental journey approximately days earlier. This is because, contrary to popular belief, sperm take approximately days to develop. Ideally, men should take a fertility supplement for 90+ days and continue until pregnancy is achieved. As a further note, it is important to understand that there is still more to know about various micronutrients and their effect on male fertility. A targeted supplementation plan in particular can provide nutrients that may be lacking due to diet, lifestyle, or health conditions. By supporting free testosterone and blood flow, Testo Dark can help increase your “pump,” improve recovery times, and boost overall lifting strength. It is designed for natural support rather than as a medical treatment for clinical conditions. Male enhancement supplements can play a key role in men’s health by boosting energy, strength, and confidence. Male enhancement supplements support stamina and energy, but they can also help with general health. Regular exercise keeps the body strong and supports the benefits of male enhancement supplements. These ingredients work synergistically to improve blood flow, increase testosterone levels, and promote overall sexual health. Most (96.4%) patients who underwent cosmetic procedures for SPA reported worsened or unchanged SPA symptoms. Psychological distress, diminished quality of life, and impaired sexual function are crucial components of comprehensive SPA assessment. With advances in technology, tissue engineering may be helpful in penile enlargement (Fig. 7). According to scientists, autologous sarcolemma cell implantation on biodegradable scaffolds is a novel and promising therapeutic strategy for a realistic increase in penile circumference. Autologous tissue engineering on a biodegradable scaffold is a novel, safe, and effective treatment for penile enlargement. Overall, the ingredients commonly found in male enhancement supplements demonstrate a favorable safety profile when used within studied limits.We assessed the amounts of each ingredient to ensure they are safe and effective in boosting testosterone levels and enhancing male sexual performance.While some men feel a boost in energy within the first week, the most significant improvements in libido and muscle tone usually occur after 30 to 60 days of consistent use.This latter category includes things like fish oil and green tea extract, which are powerful antioxidants and anti-inflammatories that have a good track record of reducing the risk of cardiovascular disease, which is a serious health problem in men.For example, 50% of men over 50 taking saw palmetto improve urinary flow, per 2025 studies.In a world where the quest for optimal health often intertwines with the pursuit of pleasure, men’s sexual health supplements have surged in popularity.Men’s vitality supplements boost energy, heart health. This underscores the importance of maintaining a healthy body weight through consistent exercise and balanced nutrition. Harvard Medical School research reveals a direct correlation between aerobic exercise and sexual function. Sexual health is intrinsically linked to overall physical and mental well-being, demanding a holistic strategy that addresses multiple aspects of personal health. A healthcare professional can provide personalized advice, conduct necessary screenings, and recommend evidence-based treatments tailored to individual health profiles. It has been shown that the sperm count of ejaculated sperms that were incubated with ginseng extract was significantly higher than those treated with vehicle.41 Treatment with ginsenoside Rg1 (50 μg/ml) significantly increases sperm motility and membrane integrity of post-thawed sperms as compared with fresh and untreated thawed sperms.42 These findings suggest that the addition of ginseng extract to the cryogen for sperm storage could enhance fertility. Ginsenoside Re (1–100 μM) has been shown to facilitate human sperm capacitation and acrosome reaction through enhancing intracellular NO production.40 Researches over the past 20 y have shown sperm counts declining in many countries across the world. A relevant aspect was the use of ineffective or underdosed ingredients that should be absent or less than possible. For an adequate evaluation of these classes, we considered the number of the effective ingredients as the most important criterion of efficacy. In this class, a large number of ineffective or underdosed products were also present. Substances with antioxidant properties are indicated in inflammation of the male accessory glands, both related to microbial and non-microbial origin. With respect to this, we want to stress that one supplement on the market contained a dose of zinc reaching the UL. “Most of these products contain unregulated, synthetic, and potentially dangerous medications and materials.” “By purchasing products like honey packs, you are potentially doing more harm to your body than good,” Dubin says. But the few studies that do exist were conducted on animals. The datasets generated during and/or analyzed during the current study are publicly available. This refined approach is essential for advancing the field and ensuring effective and patient-centric care of patients with SPA. Anti-Inflammatory Benefits Additionally, a 2024 study linked probiotics to 20% fewer digestive issues. For example, 50% of men taking probiotics report better digestion, per 2025 studies. For example, 40% of deficient men improve with zinc, per 2025 studies. A 2024 study linked zinc to better immune response. Additionally, a 2024 study found zinc cuts infection risk by 20%. Promising everything from enhanced libido to increased stamina, these products are marketed as the ultimate solution for those looking to reclaim their youthful vigor. This section collects any data citations, data availability statements, or supplementary materials included in this article. MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. It supports the production of important neurotransmitters like dopamine and norepinephrine, which are linked to focus, motivation, and mood. Enhanced mental function, increased drive in normal daily activities, and an improved sexual desire and function are advantages to men. L-Dopa regulates hormonal balance and enhances mental clarity, motivation, and energy by increasing dopamine. L-dopa is a naturally occurring compound that is a direct precursor of the "feel good" neurotransmitter called dopamine. Immune System Boost While some individuals report significant improvements in libido, energy, and performance, others may not experience noticeable benefits. These pharmaceutical components are known to improve blood flow, which can enhance erectile function and sexual performance. Before starting any supplement, it’s crucial to consult a healthcare provider. Unlike prescription medications, dietary supplements are not always rigorously tested for safety and efficacy before hitting the market. In this guide, we cover the most-studied vitamins, minerals, antioxidants, amino acids, and herbs for fertility, with dedicated sections for male fertility supplements and for fertility supplements for women. But fertility supplements can help fill nutritional gaps, support egg and sperm development, and provide targeted nutrients that can be difficult to obtain consistently from diet alone. You can drink the male enhancement liquid straight from the bottle, but some men prefer mixing the liquid supplement with water or another drink. CNY FERTILITY Houston: Most men can safely take male fertility supplements and benefit from them in some way. Although some men believe they feel younger and more vigorous if they take testosterone medications, there's little evidence to support the use of testosterone in otherwise healthy men. Testosterone therapy can help reverse the effects of hypogonadism, but it's unclear whether testosterone therapy would benefit older men who are otherwise healthy. Establishment of National and International Databases to better inform the public of the use and consequences of misuse of ED medications and supplements through clear and concise listing of ingredients on product labels. Patient was encouraged do not use over the counter sexual enhancement products; he was referred to primary care provider regarding consultation for erectile dysfunction. However, avoid taking it with other potent stimulants or hormone-altering products without professional advice. It can be paired with multivitamins or protein powders. Testo Dark is a dietary supplement and does not require a prescription. While some men feel a boost in energy within the first week, the most significant improvements in libido and muscle tone usually occur after 30 to 60 days of consistent use. The key terms used for the search were male sexual dysfunction, erectile dysfunction, impotence, phytochemical, botanicals, herbal extract, nutraceutical, dietary supplement and traditional medicine, in combination with the International Index of Erectile Function (IIEF). Moreover, patients are usually embarrassed about their erectile problems, and even in the cases where they would like to consult treating physicians about their sexual health, medical professionals are not willing to address this health problem . Nowadays, a large number of dietary supplements (DSs) formulated with variable ingredients and concentrations are available on the market, highly publicized by the media and widely self-purchased by men with ED. Unsatisfactory sexual performance can cause stress, affect self-confidence and contribute to relationship problems, which impact men’s quality of life (QoL) . In animal studies, treatment with Korean red ginseng and ginseng berry extract has been shown to significantly relax the pre-contracted penile corpus cavernosum smooth muscles of rabbits in vitro, and increase the intracavernosal pressure of rats in vivo.9,10 Data from studies on ginseng berry extract suggest that this action is nitric oxide (NO) dependent.Of all the products, eight (0.8%) matched the names of adulterated supplements that had been alerted about as illegal products in Japan before.Since a majority of them did not consult about the adverse events with anybody, including physicians, due to embarrassment, a new approach to notify about the risks of these supplements should be applied, and adverse events should be monitored.Men’s Growth is formulated to address multiple aspects of male health in a synergistic way.That said, there are a few ways to find the ideal natural testosterone booster that also increases male vitality.As such, AMS™ LGX 700® IPP insertion and postoperative vacuum device treatment is a safe and highly satisfactory combination approach to maintain penile size. The dangers of sexual enhancement supplements and counterfeit drugs to “treat” erectile dysfunction Power Drops Male Enhancement is a dietary supplement designed to support male sexual health. In Canada, a country where wellness and vitality are valued, the demand for natural male enhancement products like Power Drops Male Enhancement has risen. Among these, male enhancement supplements have gained substantial attention. It combines carefully selected natural ingredients that work together to support male health from the inside out. Men need 1000–2000 IU daily for men’s health nutrition. Additionally, a 2024 study linked vitamin D to 20% better immunity. Sunlight or supplements provide doses. For example, 60% of men taking 2000 IU daily improve bone health, per 2025 studies. Key supplements address best supplements men needs. Males with non-insulin-dependent diabetes mellitus (type 2 diabetes) often suffer from sexual dysfunction.49 Studies have found the benefits of ginseng intake. The consumption of Korean red ginseng (300 mg/kg) for 4 wk every other day has been shown to be able to prevent ZEA-induced spermatogenesis impairment in rats via modulating Fas/Fas-L expression.48 However, the unselective action of radiation therapy can also damage normal cells, leading to side effects. Radiation therapy is sometimes given to patients as part of the cancer therapy. However, this drug often leads to gonadal toxicity, and infertility as a consequence discourages many patients from choosing CP treatment. Zinc strengthens immunity, aiding men’s health supplements. Thus, zinc supports men’s vitality supplements and immune support supplements. Therefore, recovery support enhances men’s supplement routine and men’s health awareness. Therefore, anti-inflammatory benefits support men’s supplement guide and men’s health optimization. Omega-3s reduce inflammation, supporting men’s fitness supplements. Although adverse events were experienced by 17.6% of sexual enhancement users, half of them were not consulted or reported to anybody due to the temporality of the symptoms and their sense of shame. There was no product name matched to the illegal products that had been alerted about in Japan, but one respondent reported the use of a foreign product that contained Senna leaves, which are categorized as a drug ingredient and prohibited for use as a supplement product in Japan. Among animal and botanical ingredients, Maca (15.9%) was the most popular single ingredient and was also used in most of the combination products. This leads men to undergo testosterone replacement therapy, which boosts testosterone through synthetic means. This affects everything from hormone levels to lean muscle mass. Therefore, strict regulation of these products and standardization of the definition of nutraceuticals are urgently needed. In the United States, the Food and Drug Administration has banned many of these products. Some products have the real medicine in them, and the medicine should be given by prescription only. Many products that are sold without a prescription claim to be herbal forms of Viagra. Losing weight, reducing stress and a healthy lifestyle have all been shown to increase testosterone levels in men, Dr. Simone says. While many of these products say they can increase sexual desire or performance, it’s unclear if they are safe or actually work. By law, dietary supplements must contain at least one vitamin, mineral, amino acid, enzyme, or other substance used by the body. Talk to your doctor before trying a sexual enhancement supplement. “Most supplements for sexual function have not been studied scientifically,” says Luigi Simone, MD, a primary care physician at Scripps Clinic in Encinitas. Orlando de Guzman is a writer and editor with expertise in health and environmental news. Check each formula's total servings and serving size to assess its cost, and consider how long a particular supplement will last to ensure that it is within your budget. Studied ingredients have undergone a scientific review that demonstrated their ability to address common concerns of men as they age. Clinically Studied Ingredients Using clinically studied ingredients is crucial because it helps to ensure their safety, efficacy, and reliability. When curating our top recommendations, we prioritized brands with high-quality, third-party-tested products. The public notices issued in Japan about sexual enhancement products were mostly for imported products from overseas . Therefore, consulting with a doctor about the adverse events related to the use of sexual enhancement products could also be embarrassing for them. Since they participated in this survey to answer about “dietary supplements”, they may have obtained the products without prescription. However, the symptoms experienced due to the use of sexual enhancement products were mainly flushing and included similar symptoms to those reported for PDE5i, including palpitation and dizziness. Attitudes toward consulting and reporting about adverse events related to sexual enhancement (males)/weight loss (females) supplements. In detail, drug users experienced adverse events (males, 38.6%; females, 22.5%) more than supplement users; thus, the frequency of adverse events only due to the use of supplements for sexual enhancement was 11.2%, and for weight loss was 8.8%. Sources of information about sexual enhancement (males)/weight loss (females) supplements according to age groups. Physical status related to the use of sexual enhancement (males)/weight loss (females) supplements according to age groups. In the actual survey, 926 males who currently or previously used sexual enhancement supplements and 987 females who currently or previously used weight loss supplements answered the questionnaire. In today’s fast-paced lifestyle, many men experience a gradual decline in energy levels, stamina, confidence, and overall performance. Hume Health Body Pod Natural supplements like GaraHerb offer an alternative path for men seeking support without relying on synthetic solutions. Rejuvaknee Massager It is important to approach any male enhancement product with realistic expectations. I finally feel like the best version of myself again physically, mentally, and sexually. Unlike other products that overpromise and underdeliver, Titan Transform actually works. Within just a few short weeks, I experienced a major improvement in stamina, energy, and overall vitality. Although product recommendations are only our opinions, this research-backed page has been fact-checked and reviewed by a certified nutritionalist or health specialist. The only side effect is typically a boost in confidence levels as a result of having a much more fulfilling sex life. TITAN TRANSFORM has been taken by thousands of people with no reported side effects. Titan Transform helps stabilize blood sugar, so your energy stays steady and those cravings don’t take over. The physiological and psychological evaluations must be considered with patients' attitudes toward surgery to analyze the feasibility and effects of surgery and determine whether these can be achieved (Fig. 2).The average penile girth measured before and after treatment was 9.5 and 12.1 cm, respectively.Among these, male enhancement supplements have gained substantial attention.Effective testosterone boosters care so much about their customers that they willingly offer a day money-back guarantee.Radiation therapy is sometimes given to patients as part of the cancer therapy.In particular, all the studies involving zinc evaluated the effect of this ingredient at a dose exceeding UL.The blood then flows into the penis and is prevented from flowing out using a constriction ring at the base of the penis, thereby facilitating the maintenance of an erection during sexual activity.A thermogenic complex can help accelerate fat loss, but many men can find success with more a simple supplement like green tea extract. Moreover, a 2024 study linked magnesium to better mood. Avoiding caffeine enhances effects. For example, 45% of men on magnesium report less stress, per 2025 studies. A 2024 study found magnesium cuts soreness by 20%. All studies which examine the effect of multiple antioxidants in a supplementation showed an improvement in semen parameters after therapy (56, 58). Two studies showed no improvement in sperm motility and morphology after zinc therapy (46, 49). Moslemi found that combination therapy with selenium and vitamin E significantly improved sperm motility and morphology. A number of studies have shown that combined selenium and N-acetyl-cysteine therapy improved male infertility (52-54). The combination of vitamin E and vitamin C showed no improvement in either sperm count or motility, but reduced sperm DNA damage (25). In general, the long-term effects of performance-enhancing drugs haven't been studied enough. But doping can have bad effects on health. Creatine supplements may help athletes gain small, short-term bursts of power. Diuretics can cause side effects when you take them at any dose — even at doses that health care providers suggest. Sunlight or supplements provide doses.Further, there’s even evidence that many of the compounds in the best nootropic supplements can delay or prevent the cognitive declines that often come along with getting older.After 90 days of supplementation, those with both low sperm count and motility experienced a 2x increase in sperm count and a 1.5x increase in sperm count, and a 1.86x increase in sperm motility.It allows men to stay physically, mentally, and sexually youthful.In addition, the repeat surgical technique resulted in a considerable improvement in peripenile enhancement, with a mean follow-up period of 38 months.The male hormone testosterone plays an important role in the development and maintenance of typical masculine physical characteristics, such as muscle mass and strength, and growth of facial and body hair.Counterfeiters are taking advantage of this growing market by developing illicit and counterfeit PDE-5i products.L-Arginine supplements are believed to help with erectile dysfunction by promoting better circulation to the penile area. Stop taking the supplement immediately if you experience any negative side effects lasting more than a week. By balancing your hormones, testosterone boosters also improve mood and support your physical and mental confidence, allowing you to feel better emotionally. In addition, these supplements should help men stay physically youthful. Consumers are increasingly aware of potential side effects linked to synthetic solutions, which has created strong demand for natural alternatives. As men seek ways to improve confidence, vitality, and overall performance, many are turning toward natural solutions rather than synthetic or pharmaceutical options. GaraHerb Male enhancement has become a widely discussed topic in modern health and wellness conversations. Our men's white label supplement products are composed of formulas with more than ten years of research and development experience. We use pure natural plant extracts and animal extracts as the core supplement blend formula. Part of why the supplements recommended above are the best for men is explicitly because they carry little or no risk of adverse effects. In other words, a 200-pound powerlifter needs less vitamin D intake to maintain healthy levels compared to a 200-pound couch potato. Most concerningly, many of the men in the study who had vitamin D deficiency or insufficiency actually reported taking a vitamin D supplement. The odds of major vitamin deficiency are pretty low for people with a reasonable diet, but given that the best multivitamins are both inexpensive and effective, it’s not a bad idea to add one to your daily routine. If you have a sense that your diet could be better than it is, you might want to consider a multivitamin just as an insurance policy. The prevalence of vitamin D deficiency is staggering, especially for people who have jobs that keep them indoors, people with darker skin, and people who live at northern lattitudes. Thus, addressing gaps supports men’s supplement guide and men’s health optimization. Additionally, a 2024 study found supplements improve nutrient levels by 25%. Men often lack key nutrients due to diet or lifestyle, impacting men’s health supplements. Let’s dive into top men’s supplements to transform your health today! It has 12 all-natural ingredients guaranteed to increase strength, energy, and male vitality. The patients who underwent this treatment claimed various justifications for wanting to enlarge their penile circumference. Growing dissatisfaction among males regarding their penis size is driving the popularity of penile augmentation procedures that may lengthen or widen the male reproductive organ. Summary of clinically relevant studies on different penile girth augmentation methods. Effectiveness of Ingredients Among the DSs, the most used active ingredient was zinc, even if it had no supporting literature in this field. DS 4 and 7 contained at least three ingredients dosed below the mED and only one formulation (DS 5) had an EI at the right dose. In 24 formulations (88.8%), there were ingredients with a dose below the mED. Although many authors demonstrated benefits from some nutrients in the improvement of sperm parameters, their real effectiveness is still under debate.This section collects any data citations, data availability statements, or supplementary materials included in this article.Ultimately, the best approach aligns with your individual needs, preferences, and overall health goals.In a private study, 2,177 incidents of pharmaceutical crime involving seizures or police raids were reported in 2015, with 53% of them classified as commercial involving greater than 1,000 dosage units (4).Stress, anxiety, and psychological barriers can significantly impact sexual function.In some studies, marked with an asterisk, the employed dose exceeded the reported UL.The term "male enhancement supplement" refers to dietary products that aim to support sexual health through various mechanisms, including improved blood flow, hormonal modulation, or antioxidant protection. With the right guidance, men can optimize their health at any age while avoiding unnecessary risks. To help you find the best supplement to meet your needs, we asked four registered dietitians to share their recommendations for men. Explore expert insights, real consumer feedback, and unbiased comparisons to help you choose the best products with confidence. It doesn’t claim to be a “magic pill” but rather a potent tool for men who are already committed to improving their health through diet and exercise. In a market flooded with empty promises, Testo Dark Male Enhancement stands out by focusing on a transparent, science-backed blend of ingredients. There is sure to be a testosterone booster for your needs. They control the enzymes that direct the flow of blood, giving more powerful erections and even improving a man's sperm count. You can use them for various purposes without relying on a supplement stack. If you take male vitality pills separately from test boosters, you must also be wary of headaches, body overheating, vision and hearing loss, and cardiovascular issues. As we noted earlier in this article, many people usually have natural supplements in mind when they talk of male enhancers. Numerous offerings on the market are targeted at helping to improve male sexual health and performance. There are different types of approaches and products for male enhancement. Another benefit that some male enhancement products are said to offer is greater satisfaction. Of these food products, sexual enhancement supplement products accounted for the highest proportion (36.8%) followed by weight loss supplements (31.3%). Consumers expect to gain health benefits from these supplements, but there are inherent risks of adverse effects caused by the ingredients themselves and interactions with medicinal drugs . A placebo-controlled trial found that ashwagandha supplementation improved sperm count, motility, semen volume, and testosterone levels in oligospermic males. The effectiveness of Power Drops Male Enhancement relies on its carefully selected blend of natural ingredients. Results may vary from person to person, but based on my experience so far, it seems like a reasonable option for men looking for general performance support. I wasn’t expecting dramatic or instant changes, but over time I noticed a gradual improvement in my energy levels and overall confidence. The formula aims not just at performance, but also at endurance, circulation, energy, and long-term wellness.See more Heater By supporting the body’s natural processes, it may help improve confidence and overall satisfaction when combined with a healthy lifestyle. Proper blood flow and balanced energy are essential components of male performance, and herbal formulas aim to address these factors holistically. Heater These extracts are often chosen for their historical use in supporting circulation, energy levels, and endurance. In recent years, there has been a shift toward plant-based supplements for men’s wellness. Based on the scoring system, 2 (8%) supplements matched with the cluster of higher expected efficacy, 3 (12%) with the lower efficacy cluster and 20 (80%) matched with the criterion of no expected efficacy. A metanalysis identified some nutraceuticals, such as Panax ginseng, Tribulus terrestris and L-arginine, that are able to improve male sexual function. However, none of the studies carried out provided sufficient evidence to consider these products a first-line therapy. The supplement is expensive, so that is a consideration if you are on a budget. However, some providers recommend greater doses for certain health issues, such as muscle cramps or spasms, migraine headaches, insomnia, and constipation. Pure Encapsulations Magnesium Glycinate is our pick for the best magnesium supplement, and Dr. Young agrees. You can purchase this supplement as a tablet, capsule, or softgel. Now Foods Adam Men’s Multiple Vitamin is our pick for the best multivitamin for men. Other ingredients like ginseng, maca root, and folic acid have demonstrated limited but interesting results in some research contexts. Sexual health is a complex interplay of physical, psychological, and emotional factors that require comprehensive, professional approach. They can offer personalized advice, conduct necessary health screenings, and recommend evidence-based treatments tailored to individual needs. Self-medicating with unverified OTC remedies masks potential critical health problems and delays necessary treatment. Nutrients are vitamins and minerals in foods that are good for you. Doping with erythropoietin may raise the risk of serious health problems. A health care provider can prescribe human growth hormone for some health reasons. However, the herbal extract is to be considered useful because all the RCTs in which it was tested showed positive effects. They are the active ingredients to which the effectiveness of ginseng is attributable . In this meta-analysis, we included five studies with a high or not fully understood risk of bias (except the paper by de Andre et al.), limiting the weight of the evidence. Terrestris could be useful in supporting organic ED. More specialized supplements, or those with somewhat less convincing evidence, ended up lower in the rankings. Then, having identified issues ranging from cardiovascular disease to cognitive decline to a loss of strength and vigor in middle and old age, we sought out the best supplements to help address these issues. Because the category of supplements that might benefit men is so broad, we took a different strategy than usual to come up with our rankings. These products, along with a healthy lifestyle that includes physical activity and a healthy diet, can go a long way towards improving your short-term wellbeing and your long-term health. A thermogenic complex can help accelerate fat loss, but many men can find success with more a simple supplement like green tea extract. It may be the case that there are negative effects that don’t emerge right away, but again, this is hypothetical, not proven. While no supplement can completely replace real fruits and vegetables, green drinks do a pretty good job. By studying a large group of Finnish men over the course of several years, the researchers were able to examine how dietary intake influenced risk of death from cardiovascular disease. This is problematic as vitamin D is important for many vital biological functions, including hormone production, sperm development, and overall male fertility and reproductive health. Largely due to its role as an antioxidant and energy generator, it has been highly studied and shown to be one of the most powerful supplements for male fertility. Several other studies have supported these findings making Vitamin C an important dietary supplement to consider for male fertility. In one study, researchers, researchers looked at sperm count and motility before and after vitamin C supplementation. Most of the studies reviewed included patients with various causes of ED. A total of 23 studies (only RCTs) were finally included in this study. The literature review on ingredients identified 194 records published from 1987 onward, yielding 110 potentially eligible studies. Then this score was weighted for the total number of ingredients in the supplement (N). While these drugs are known to be effective, their use tends to come with more side effects. Popular erectile dysfunction (ED) medications such as Viagra and Cialis are considered examples of synthetic male enhancers. Of all these products available on the market today, pills are arguably the most popular ones due to their convenience in use. For example, the administration of standardized ginseng extract (100 mg/kg) daily for 90 d in streptozotocin-induced diabetic rats has been shown to result in a significant improvement of fertility parameters and decrease in testicular pathological signs, such as degenerative changes of the seminiferous tubules.50 Furthermore, the consumption of Korean red ginseng (30 mg/kg, three times a week for 1 mo) can help streptozotocin-induced type 2 diabetic male rats to improve on libido and sexual performance.51 In addition, ginseng has been shown to be able to stabilize diabetes disease progression. In addition, ginseng is found to improve the sperm quality and count of healthy individuals as well as patients with treatment-related infertility. Data from animal studies have shown a positive correlation among ginseng, libido, and copulatory performances, and these effects have been confirmed in case-control studies in human. When it comes to finding the perfect male enhancement pill, there are some considerations that should be most important to you. Several studies have shown sperm count to be higher and spermatic DNA to be less damaged in men with higher seminal folate levels. That said, clinical results from studies looking at folate supplementation and sperm quality are mixed. Other studies have shown that supplementing with zinc improves sperm motility and count. Studies also suggest that vitamin E can also help improve sperm morphology and natural pregnancy rates. Vitamin E is another common vitamin that routinely shows up in fertility supplements for men due to its role as an antioxidant. Additionally, a 2024 study found lifestyle tweaks improve supplement efficacy by 20%. Lifestyle changes complement supplements. For example, 55% of stressed men have lower magnesium levels, per 2025 studies. For example, 60% of men are deficient in vitamin D, per 2025 studies. Without a doubt, the most effective testosterone supplement on the market is TestoPrime. That's extra important if you're taking medicines or you have a long-term health condition such as heart disease or diabetes. They also can have dangerous effects when taken with some medicines. Just because a product claims to be natural doesn't mean it's safe. To avoid these pitfalls, always look for products that have been third-party tested or certified by organizations like NSF International or USP. As curiosity piques and interest grows in improving sexual wellness, it’s vital to separate fact from fiction. Navigating through this maze of options can feel overwhelming, especially when so much is at stake—your health, your confidence, and even your relationships. Male enhancement supplements don’t just improve physical energy. Some people try to get more nutrients from products called supplements. Learn more about the effects that performance-enhancing drugs can have on health. By supporting blood circulation, energy levels, and hormonal balance, Revra aims to help men feel more confident not just in intimate moments, but also in their everyday lives.See more It is made with premium ingredients that improve overall health, sex drive, and vitality. It's delivered results repeatedly, increasing testosterone levels and allowing men to reap the rewards. We'll examine some of their vegan, organic ingredients and what makes them better than most testosterone boosters. Men who experience low testosterone as they age lose their vitality and ability to perform sexually. Lifestyle changes can be effective in treating sexual problems. “Your doctor can discuss any sexual concern you may have and determine if there is an underlying cause for your symptoms that needs to be treated.” In additions to nutrients like amino acids, vitamins and minerals, they may contain herbs, such as horny goat weed, ginseng and maca root. The FDA can take action if it finds any supplement to be unsafe once it reaches the market and can remove the product from the marketplace. But the rest of the ingredients may include drugs that are untested for safety or effectiveness.