Always be cautious about sunburn and skin damage—use sun protection as needed after the initial exposure window. Supplementation, when needed, can be an effective way to reach optimal vitamin D status in 2025. Men with lower vitamin D often report feeling less energetic and more prone to mood swings, both of which can be linked to hormonal imbalance. A total of 366 male participants were recruited for the studies, with ages ranging from 18 to 72 y and samples sizes ranging from 16 to 120 participants. Six studies (42, 53, 57, 58, 63, 64) were conducted examining the effects of fenugreek seed extracts on testosterone concentrations. A total of 512 male participants were recruited for the studies involving Asian ginseng, with ages ranging from 18 to 79 y and samples sizes ranging from 8 to 143 participants. Endothelial dysfunction is a key variable in the pathogenesis of atherosclerosis and its complications, including erectile dysfunction (ED).{Additionally, the association between serum 25(OH)D and bioavailable testosterone was only significant for men with very low vitamin D levels (26}.Recent observational studies show that men with sufficient vitamin D levels tend to have higher testosterone levels compared to those who are deficient.However, most of these studies have yielded inconclusive or conflicting findings or a lack of benefit for its use, illustrating the need for studies of higher quality in this area.Consequently, the United States Food and Drug Administration (FDA) has approved ω-3 PUFAs for the prevention of CV adverse outcomes by the postulated mechanism of lowering serum triglyceride levels 162,163.Fixing your vitamin and mineral imbalances for optimal testosterone production starts from optimizing the diet and then using a solid multivitamin for testosterone production.However, those dietary supplements don't just increase testosterone levels.Research consistently shows that men who engage in regular resistance training experience higher testosterone peaks.|} Study - Elderly with Vitamin D supplement do not have risks of low testosterone levels. Hence, low amount of Vitamin D3 can lead to low testosterone levels. It controls and manages all the bodily functions, especially virility, hormones, and sexual activity. In men, Vitamin D3 is essential for development of sperm cells, maintenance of sperm counts and enhancing the testosterone levels, along with an accelerated sexual drive. Most of the observational studies demonstrated that serum level of 25-hydroxy-vitamin D3 was not related to circulating concentrations of total or free testosterone 59,60,61,62,63,64,65,66, with one study exception . The documented increase in 25-hydroxyvitamin D levels, however, did not affect mean testosterone concentrations at the end of the study (median increase of 0, 0.5 and 0 nmol/l in studies 1, 2 and 3, respectively). Serum testosterone levels are not modified by vitamin d supplementation in dialysis patients and healthy subjects. On the other hand, testosterone deficiency is a very common feature in males with obesity, in which there is a causal effect of an increased BMI on serum testosterone levels in men (28). This essential nutrient acts as a hormone in the body and directly influences testosterone production, which is vital for male fertility and overall reproductive function. If you want to protect yourself from erectile dysfunction and other concerning ailments, it’s best to visit a healthcare provider to get a proper diagnosis. From the conflicting evidence above, it’s safe to say that more research needs to be done to better understand the link between vitamin D and testosterone. To combat this, early morning sun exposure is a key player in the production of this essential vitamin. Thanks to its bone-promoting and immunity-boosting properties, Vitamin D is critical for adults who are looking to stay healthy. Effects of vitamin d supplementation on insulin sensitivity and androgen levels in vitamin-d-deficient polycystic ovary syndrome patients.At study’s end, researchers reported that higher D levels were tied to higher total and free testosterone levels in the men.Hormone Replacement Therapy (HRT) is often employed to counteract the effects of hypogonadism – a condition characterized by low levels of testosterone.Testosterone also supports libido or sex drive, sperm production, and overall sexual health.This remarkable “female advantage” is lost with menopausal transition or metabolic diseases such as diabetes, which significantly increased the incidence of cardiovascular morbidity and mortality in post-fertile women life, as summarized elsewhere 13,14.First, the cross-sectional nature of this study may be one of these limitations, as we can only hypothesize based on the cross-sectional design.Meanwhile, too much vitamin D3 will result in nausea, high blood pressure, and other cardiovascular issues. Should You Start Taking Vitamin D Supplements? Daily supplementation with 1.5 g Korean red ginseng (6-y-old ginseng, steamed, dried, and powdered) over 12 wk resulted in no significant between-group differences in testosterone concentrations. Two studies out of 32 included both male and female participants (2488 participants in total; 2446 males and 42 females). Summary of randomized controlled trials examining the effects of herbs on testosterone concentrations in men1 From the age of 30 onwards, testosterone concentrations in men tend to decline at the rate of ∼1% per year (1–6). This systematic review includes randomized controlled trials examining the effects of herbs, spices, plants, and their extracts on testosterone concentrations in men. Dietary supplementation with linseed oil improves semen quality, reproduc-tive hormone, gene and protein expression related to testosterone synthesis in aging layer breeder roosters. Modulation of age-related biochemical changes and oxidative stress by vitamin c and glutathione supplementation in old rats. Effects of branched-chain amino acid supplementation and/or aerobic exercise on mouse sperm quality and testosterone production. These results are contrary from those were carried out on females green frog and female lizards, in which these differences assume different effect of D-Asp depending on species, sex and organ-specific (4, 6, 41). The characteristics and outcomes of the included human studies The characteristics and outcomes of the included animal studies Furthermore, the study, which had a relatively smaller sample size compared to Chen et al., found that the vitamin D-related gene polymorphisms did not modify the relationships between serum 25(OH)D levels and sex hormones or gonadotropins. Men with lower serum 25(OH)D levels, particularly those below 25 nmol/L, tended to have lower total and bioavailable testosterone levels compared to men with higher serum 25(OH)D levels. Additionally, only a small percentage (2.7%) of the study subjects in Chen et al.'s study exhibited severe vitamin D deficiency, limiting the ability to establish a direct correlation between severe vitamin D deficiency and testosterone deficiency . Chen et al. conducted an MR analysis on a cohort of 4254 Chinese men to explore the potential causal relationship between vitamin D deficiency and testosterone levels . Oats are an excellent source of B vitamins which are key to good testosterone production. A good – testosterone friendly – diet includes plenty of healthy fats, leafy green vegetables and protein. Check out the best breakfast foods that boost testosterone levels. The more testosterone your body produces, the more your muscle mass and strength will increase. So, let’s delve into why your breakfast choices matter and explore five essential foods that can help you kickstart your day with a powerful boost to your testosterone levels. For instance, one study found that men with higher levels of vitamin D had significantly higher testosterone levels. We’ve seen a bunch of studies that show how vitamin D can really help boost testosterone levels. Getting enough vitamin D is super important for our overall health, especially for keeping our testosterone levels in check. Studies show that higher levels of vitamin D can lead to increased testosterone levels. We process personal information and consumer health data to provide you with our products and services and maintain essential website functionality. Everything you should know about one of the most important hormones in your body. Learn what it takes to boost energy, maintain strength, and stay healthy longer—delivered to your inbox every Monday. Multivitamin rating based on results of the 2024 ConsumerLab.com Survey of Supplement Users. Discover nutrients you need for optimal health Here he underscores the importance of hormone testing—and the benefits of bioidentical hormone replacement therapy. Values are means (SD) or percentages and are standardized to the age distribution of the study population. In a sensitivity analysis, we tested whether additional adjustment for batch-specific deciles of plasma cholesterol, which is a precursor for both testosterone and vitamin D, changes associations. Multivariate adjusted mean sex steroid hormone concentrations and corresponding 95% confidence intervals (95% CI) were calculated by batch-specific quintiles of 25(OH)D. As an alternative approach we calculated free testosterone from total testosterone and SHBG under the assumption of a constant albumin concentration of 43 g/l according to Vermeulen et al. 12. The objective was to cross-sectionally examine the relationship between serum vitamin B12 and male reproductive hormones (luteinizing hormone, follicular stimulating hormone, total testosterone, estradiol, and prolactin). In conclusion, this is the first study to compare total 25(OH)D and directly measured free 25(OH)D in a relatively large cohort of healthy reproductive age women. If these young women get pregnant, the situation changes, then, the rising levels of female steroids hormones do substantially induce hepatic synthesis of vitamin D binding protein (58) and hence free 25(OH)D is much better correlated with markers of bone metabolism (calcium, BSAP), lipid metabolism (adiponectin, LDL cholesterol, LDL/HDL ratio) and kidney function (urea) than total 25(OH)D (32). It is a key finding of the current study that laboratory parameters describing androgens such as free androgen index (FAI), total testosterone and androstenedione are among the parameters with the strongest negative correlation between either free or total vitamin D in reproductive-age Caucasian women. Additionally, this hormone influences mood, energy levels, and cognitive functions, contributing to mental well-being. Testosterone is a crucial androgen hormone in the male body. By understanding this link, we can better appreciate how vitamin D3 supplementation might influence hormonal health and overall well-being. They support the body’s energy metabolism and help in the formation of red blood cells, indirectly influencing testosterone levels. Regular intake of vitamin C rich foods or supplements can be a good strategy to keep testosterone at optimal levels. They can help optimize testosterone levels in the body. If the recommended dosage is consumed, then one will not experience any effects. Natural sunlight is a boon for your testosterone production. In case your Vitamin D levels are already in the right amount, then you won’t get the testosterone-boosting effect with the Vitamin D supplement. Thus, it shows how sunlight is important for a man’s health and one should take advantage of it. The 2 studies that showed no effect of fenugreek supplementation on TT concentrations (57, 63) recruited healthy men, with participants in the Rao and Grant (57) study including men with benign prostate hyperplasia (BPH). Concerning the specific topic on female heart function, a quite recent study postulates a synergistic role of vitamin D and E2 in postmenopausal women with metabolic syndrome, a cluster of simultaneous cardiovascular risk factors, leading to an increased risk of heart disease, stroke and T2D, as previously mentioned . This review evaluates the effect of vitamin D supplementation on male fertility, focusing on total testosterone, free testosterone, the free androgen index (FAI), follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex-hormone-binding globulin (SHBG), and estradiol. Antioxidant, anti-inflammatory, and anti-apoptotic effects of zinc supplementation in testes of rats with experimentally induced diabetes. Min Y, Sun T, Niu Z, Liu F. Vitamin c and vitamin e supplementation alleviates oxidative stress induced by dexamethasone and improves fertility of breeder roosters. Mohasseb M, Ebied S, Yehia MAH, Hussein N. Testicular oxidative damage and role of combined antioxidant supplementation in experi-mental diabetic rats. Radhakrishnakartha H, Appu AP, Madambath I. Reversal of alcohol induced testicular hyperlipidemia by supplementation of ascorbic acid and its comparison with abstention in male guinea pigs. Sodium arsenite toxicity on hematology indices and reproductive parameters in Teddy goat bucks and their amelioration with vitamin C. Test Your Blood LevelsA simple blood test called 25(OH)D will determine your current Vitamin D levels. Maintaining sufficient Vitamin D levels doesn’t require drastic changes but does call for consistency. Vitamin D may also benefit mental health by promoting mood stability. Chronic inflammation can interfere with the hypothalamus-pituitary-gonadal (HPG) axis, a key hormonal pathway that regulates testosterone output. Longitudinal studies report that approximately 35% of men on LHRH agonists experience at least one skeletal fracture and approximately 20% will be diagnosed as osteoporotic or osteopenic within 7 years of starting therapy . Additionally, cross-sectional studies have shown that men receiving ADT are more likely to meet the diagnostic criteria of MetS 94,95. Thus, side effects induced by ADT leading to hot flashes, osteoporosis, MetS and higher CV events are related to androgen as well as estrogen deficiencies 35,38. Consequently, hypogonadism is prevalent in PCa patients undergoing ADT compared to those that undergo surgery and/or radiation therapy or compared to age-matched controls . Women’s Health Nevertheless, as of today, only a few studies have investigated the effect of vitamin D on testosterone levels in the context of obesity, despite the previously mentioned data that strongly suggested a feasible relationship. Low serum 25-hydroxyvitamin D (25(OH)D) (the circulating form of vitamin D) levels have also been linked to low testosterone levels. Additionally, testosterone supplementation/replacement in men with obesity had a positive effect on body composition and BMI (12, 13), indicating a close connection between adiposity and testosterone levels. On the other hand, obesity was largely related to an increased risk of low levels of testosterone in males, and this observation was consistently confirmed by several observational studies (10, 11). By maintaining proper vitamin levels through diet and appropriate supplementation, you’re taking proactive steps to support your reproductive health. This means that testosterone may have a greater physiological effect in the body when concentrations of these biomarkers are elevated. In this review, Asian ginseng only had 1 study out of 7 demonstrating a positive effect on testosterone concentrations in men; however, its administration reduced cortisol concentrations in adults experiencing high work stress (78). Moreover, in animal studies, the administration of 4-hydroxyisoleucine, an extract from fenugreek seeds, lowered serum cortisol concentrations (77). A very short-term (4 days) and a short-term (3 months) supplementations weren't capable to influence circulating levels of total testosterone 79,80. To date, there is not sufficient data to establish a certain relationship between vitamin D status and testosterone levels. Indeed, some studies not showed a relationship between circulating 25-hydroxyvitamin D3 and total testosterone, free testosterone or SHBG 69,70,71, while others stated a positive association with total or free testosterone 72,73,74,75,76,77. Furthermore, possible bias, including age, body mass index, and baseline vitamin D status justified the differences among studies. The consequences of VDD on serum levels of testicular hormones have been analysed by several studies, with controversial results. The good news is that there are proven methods to increase testosterone levels, ranging from simple lifestyle adjustments to medically supervised therapies. Additional data are not only required regarding the actual association of D-Asp with testosterone levels but also concerning the safe and maximum effective dose of D-Asp supplements for humans. The small sample sizes most likely precluded the examination of important moderator variables such as age, weight status and basal testosterone levels. However, in the study of Bloomer et al, 6 gr daily of D-Asp had no effect on the testosterone levels (50). This is contrary with the hypothesis that D-Asp supplementation is effective with lower testosterone levels. Study In this study, it was proven that men with higher Vitamin D levels have higher testosterone levels as well in comparison with men with lower Vitamin D levels. However, further well-designed RCTs are needed to determine vitamin D's effects on other reproductive hormone parameters. The primary focus of these studies was on reproductive hormone parameters, analyzed using a random-effects meta-analysis and weighted mean difference (WMD). Thankfully, there are a number of testosterone boosting supplements on the market with all the Vitamin D you’ll ever need – like TestoMax, with 262% of your RDA.Consuming a balanced diet rich in these nutrients while ensuring sufficient vitamin D levels can optimize hormonal health in 2025.This is DIFFERENT from testosterone therapy, like testosterone pills.Participants were divided into two groups based on their serum 25(OH)D levels (134 subjects with vitamin D sufficiency and 135 participants with vitamin D deficiency, according to the 50th percentile of 25(OH)D).Lower testosterone production can result in less energy, less muscle mass, reduced sexual desire and increased risk of osteoporosis.Furthermore, while most vitamin D supplementation studies conducted evaluations after a treatment period as short as 3 months to as long as 6 months, this study conducted vitamin D supplementation for one year.D-Asp plays an important role in the biosynthesis and/or secretion of hormones in endocrine glands.Please check with your doctor of choice for information regarding your own personal health profile and needs. Sleep and Testosterone: The Essential Connection for Optimal Health What is new about this study, is that we can show that vitamin D influences testosterone production. But one of the best ways to raise testosterone levels is hormone replacement therapy. More recently, a study in the journal Nutrients found that soccer players who were exposed to 10 days of sun and six weeks of Vitamin D supplementation had significantly higher levels of testosterone (5). Nevertheless, vitamin D has been recently investigated for its role in male and female fertility.Three studies used a randomized, double-blind, placebo-controlled study design (35, 51, 62), and 1 study used a randomized, double-blind, placebo-controlled, crossover study design (50).Through a comprehensive analysis of these studies, we will explore the findings and insights obtained, providing valuable insights into the effects of vitamin D on androgens and testosterone levels.Research indicates that correcting vitamin D deficiency not only improves bone health but also positively impacts testosterone levels.One of the mechanisms involved in this process is the physiological suppression effect of vitamin D on renin, angiotensin II, and aldosterone .Quantitative meta-analysis was not done because of various designs of included studies and small amount of human studies.D-Aspartic acid (D-Asp) is in invertebrate and vertebrate neuroendocrine tissues, where it carries out important physiological functions.By some estimates, nearly half of all people are vitamin D deficient, and there is mounting evidence that some of this may be triggering lower than normal testosterone levels.However, overdoing it with supplements can lead to these issues.A healthy lifestyle, including proper nutrition and exercise, is key to maintaining good testosterone levels. How to Maintain Healthy Vitamin D Levels In cardiomyocytes, estrogens regulate cell contractility affecting Ca2+ dependent signaling, mitochondria function and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) system. From the pioneering studies, the role of estrogens in cardioprotection has been essentially related to the arterial vasodilation through direct genomic and non-genomic actions onto vascular cells 16,17,18,19. Women are more frequently affected by hypertension (which likely contributes to the different left ventricular dysfunction and arterial stiffness) and are more prone to cardiometabolic syndrome (which exacerbates sex-related bias in cardiac disease occurrence) and disease sequelae, as addressed later in this manuscript. At The Doctor’s Practice, we offer comprehensive health assessments to identify deficiencies and create a personalised plan to help you feel and perform at your best. These are signs your body is asking for support. His blood tests showed low testosterone and severe Vitamin D and Magnesium deficiencies. Let’s take a look at why these three nutrients are essential for testosterone optimisation. Figure 1 Scatter plots depicting bivariate associations between free 25(OH) D and total 25(OH)D. Those with very low levels may need short-term higher doses under guidance. Aim for 1,000–5,000 IU daily, adjusting based on your current levels (sun exposure, skin tone, and diet all play roles). Even when you do eat these foods, modern farming practices have depleted soils of key nutrients, making supplements a practical backup. Fermented foods are K2 kings, think natto (a Japanese soybean dish), unpasteurized sauerkraut, and aged cheeses. If you suspect a shortage but aren’t sure, trying a quality D3+K2 supplement for 2-3 months while tracking how you feel often gives clearer answers than lab work alone. In this systematic review, many studies were underpowered, making it difficult to obtain statistically significant, between-group differences. Moreover, fenugreek seed extracts also demonstrated a positive effect on BT concentrations. Similarly, in vitro studies demonstrated reishi's ability to inhibit the activity of 5α-reductase (79, 86, 87). For example, inflammation and oxidative stress have an inverse relationship with testosterone, as demonstrated by several human and animal trials (9, 81–83). If you’re concerned about your vitamin levels or reproductive health, consult with your healthcare provider for personalized recommendations. Remember that reproductive health is just one aspect of overall wellness, and proper vitamin intake supports multiple bodily functions. Maintaining optimal vitamin levels plays a crucial role in men’s reproductive health and fertility. In adult male rats, NMDA has been shown to act on the hypothalamus, inducing an increase of gonadotropin releasing hormone (GnRH); in the pituitary gland, GnRH induces LH release; and in the gonads, LH facilitates testosterone release (30). Another strength of our study is that testosterone levels were measured by HPLC, providing a more precise value. First, this is the first study to examine the effect of BMI on the relationship between 25(OH)D and testosterone, adding new evidence to the body of knowledge about the impact of BMI on metabolic hormones. Vitamin D helps regulate nitric oxide, a molecule that relaxes blood vessels and increases blood flow, crucial for achieving and maintaining an erection. Testosterone isn’t the only thing affected by vitamin D. Vitamin D receptors are found in the testes and pituitary gland, suggesting that they can influence testosterone synthesis and hormonal signaling. While the findings aren’t absolute and there is a need for further research of more diverse populations, some studies suggest a positive, related correlation between the two. Despite its importance, an estimated 40–50% of U.S. adults are vitamin D deficient, and the number may be even higher in men who work indoors or live in northern climates. This study employed a cross-sectional design to assess the relationship between serum vitamin B12 concentrations and reproductive hormones. Therefore, the objective of the present study was to assess the association between serum vitamin B12 concentrations and reproductive hormones in a population of men experiencing infertility. The effect of estrogens on vitamin D binding protein and hence the relationship of free and total 25(OH)D is obviously negligible in a study population of healthy women with the same genetic background. From a biochemical aspect, both androgens and vitamin D belong to the steroid family. The results of bivariate correlations of the 508 women are given in Supplementary Tables 3 and 4. Scatter plots depicting bivariate associations between free 25(OH) D and total 25(OH)D. Free 25(OH)D (25-hydroxyvitamin D2 and D3) was measured using a commercial kit from Future Diagnostics Solutions B.V. For instance, too much vitamin A can be toxic, while high doses of zinc may interfere with copper absorption.Serum vitamin B12 concentration was grouped into tertiles instead of being categorized based on deficiency and elevated concentration cutoffs.All information presented here is not meant as a substitute for or alternative to information from health care practitioners.Testosterone levels were measured using a 2nd generation immunoassay.Moreover, some authors suggested the hypothesis that vitamin D genomic stimulation of osteocalcin expression might have a central role in regulating testosterone production by the testis .In the present study we observed that both total and free 25(OH)D were inversely correlated with FAI, LH, total testosterone, AMH, androstenedione, TSH, and positively correlated with SHBG in reproductive-age women.Luckily, boosting your intake of essential nutrients can reverse testosterone decline.Hone-affiliated medical practices are independently owned and operated by licensed physicians who provide services using the Hone telehealth platform. Some studies have reported a significant correlation between vitamin D levels and serum testosterone levels 12,13, whereas other studies have been unable to prove it with statistical significance 14,15. Although there is no direct effect on serum testosterone levels, vitamin D supplementation helped improve hypogonadal symptoms. “We are now awaiting data from a large study in which we have given infertile men with vitamin D deficiency high doses of vitamin D to determine whether this can increase their testosterone production and improve their fertility,” explains Martin Blomberg Jensen. Similarly, the effects of vitamin D supplementation on testosterone levels remain inconclusive, with limited evidence of notable changes in TT but potential influences on SHBG and FT levels. A plethora of new research on this critica vitamin has shown it plays vital roles in more than just bone health. Also known as D-aspartate, this amino acid is produced in the pituitary gland where it stimulates the release of luteinizing hormone, which travels to the testicles and boosts T production. Make sure you keep your T levels topped off with these three supplements. Latest articles Biochemistry, Physiology and Diagnostics (2018) Volume 1, Pages 925–37. Patel NM, Gutierrez OM, Andress DL, Coyne DW, Levin A, Wolf M. Vitamin D deficiency and anemia in early chronic kidney disease. Hormone profiling, including anti-Mullerian hormone (AMH), for the diagnosis of polycystic ovary syndrome (PCOS) and characterization of PCOS phenotypes. Nevertheless, a general consensus about the role of vitamin D in male fertility is still debated. Agreeing to get blood analysis panels for testing hormone deficiency does not always establish a medical necessity. As research continues to evolve, the integration of Vitamin D assessment and management in clinical settings, particularly in the context of hormone replacement protocols, holds promise for enhancing patient outcomes. Ensuring adequate Vitamin D intake through diet, supplements, and sensible sun exposure can be a simple yet effective strategy to enhance overall hormonal health. For American men, particularly those at risk for or currently experiencing androgen deficiency, regular screening for Vitamin D levels should be considered. In the bariatric-surgery studies, the average 32% weight loss was linked to a testosterone increase of 8.7 nmol/L (251 ng/dL). In other words, a man increasing his intake of Vitamin D3 would help his body produce more testosterone in modest levels because it aids in the production process. Since almost all generation of testosterone in the male body comes from the testes, the production of this substance uses different elements in order to create the testosterone itself. Vitamin D is a testosterone booster, but if your vitamin D levels are already optimal (most men don’t fall into this category), then extra supplementation won’t help. However when the amount of vitamin D in serum goes above ~80 nmol/L (pretty much optimal), the increase in testosterone plateaus. This remarkable “female advantage” is lost with menopausal transition or metabolic diseases such as diabetes, which significantly increased the incidence of cardiovascular morbidity and mortality in post-fertile women life, as summarized elsewhere 13,14. Indeed, vitamin D deficiency increases the risk of CVD development, impacting cell morphology, metabolism and function 9,10. Indeed, women show a higher prevalence of age-related cardiac defects, including left ventricular hypertrophy, increased end-diastolic pressure, diastolic dysfunction, fibrosis, inflammation, oxidative stress and lower exercise capacity . As a result, the brain released LH hormone and the testosterone levels boosted up. This study emphasized the significance of natural UV rays for raising the testosterone levels in men. Soil fertility 1 Importantly, further systematic studies assessing the safety and efficacy of black cohosh in alleviating ADT-induced side effects may be worth pursuing. Of interest is one study that was carried out in orchidectomized male rats and showed to prevent osteoporosis in vivo . The herbal supplement black cohosh, which is approved for the treatment of menopausal symptoms by the German health authority (Commission E), has also shown to have MetS-preventive and bone-protective properties in recent preclinical studies 59,114. The use of dietary supplements to alleviate side effects of ADT is an attractive approach for the majority of PCa patients. And we also found that both vitamin D metabolites are negatively correlated with hsCRP, which draw attention to the hypothesis that low 25(OH)D maybe involved in the chronic inflammation. As mentioned above, this would require adequately designed dose-finding studies. Vitamin D concentrations for an optimal androgen status, fertility rate and embryo development in humans are currently unknown. The expression of this enzyme was reported to be regulated by 1α,25-dihydroxyvitamin D3 in human prostate cell lines and keratinocytes (43, 44). Asian ginseng also has antioxidant properties, which reduce lipid peroxidation and increase glutathione peroxidase concentrations (74), and it is noteworthy that the only study demonstrating benefits of Asian ginseng recruited individuals with metabolic syndrome (47). Despite a lack of robust support for herbal supplementation increasing testosterone concentrations in men, there are potential mechanisms of action. This meta-analysis included 4 studies (42, 58, 63, 64) but did not include 2 of the studies included in this review because it was conducted in late 2018 and excluded studies with a duration 69) conducted a systematic review on all tribulus studies examining various forms of testosterone in animals and humans and concluded that the evidence indicated that it is ineffective at increasing testosterone concentrations in humans. The paucity of high-quality randomized controlled trials examining the effects of herbs on testosterone concentrations in men, along with the heterogeneous cohorts assessed in these trials, precludes definitive conclusions being made. There were no statistically-significant increases in testosterone concentrations after 12 wk of supplementation in any of the trials. A total of 126 male participants were recruited for the studies, with ages ranging from 20 to 56 y and sample sizes ranging from 20 to 56 participants. Three randomized, double-blind, placebo-controlled studies (41, 52, 66) examined the effects of maca on testosterone concentrations. Vitamin D3 can increase a man's testosterone levels by 20%, but the effect seems to be more pronounced in those who have a vitamin D deficiency.(2) Researchers in this study concluded D supplementation “may increase testosterone levels.”9 Including vitamin K2 rich foods or supplements can be a step towards healthier testosterone levels. Although some supplements may help maintain healthy testosterone levels, many that are marketed as testosterone boosters are ineffective, although they might enhance libido. Thus, both age and BMI did not modify the linear relationship between serum vitamin B12 concentrations and reproductive hormones. Take control of your hormonal health today — because investing in your vitality is investing in your overall quality of life. Whether through moderate sun exposure, nutrient-rich foods, or appropriate supplementation, prioritizing Vitamin D is a smart move toward holistic well-being. By maintaining adequate levels of this essential nutrient, men may notice improvements in energy, mood, mental clarity, and sexual wellness. Vitamin D - Good for Increasing Bone and Muscle Strength Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. Should we measure free or total 25(OH)D to assess vitamin D status? Maternal serum 25-hydroxyvitamin D and placental vascular pathology in a multicenter US cohort. Vitamin D levels should be monitored when men are using supplements in excess of 1,000 IU daily. Men should be careful when using high dose vitamin D supplements. The only way to know for sure is with a simple blood test measuring your 25-hydroxyvitamin D levels. For optimal absorption and safety, take supplements with meals unless otherwise directed by your healthcare provider. This is particularly important as some supplements can interact with medications or existing health conditions. If you notice any of these symptoms, it’s important to consult with a healthcare provider before starting any supplementation. Mood changes, including irritability or depression, may suggest low vitamin D or B-complex vitamin levels. Hair loss or slow-growing, brittle nails might signal insufficient biotin (vitamin B7) or vitamin E levels. Thus, both ways of analyzing the vitamin D status in healthy reproductive age women with regard to the evaluation of endocrine fertility parameters are suitable tools. The strength of correlation of free and total 25(OH)D and endocrinological, hematological and biochemical parameters was similar in healthy reproductive age women. There is, however, a small study in healthy women showing a positive correlation between androgens and total vitamin D (25). In the present study we observed that both total and free 25(OH)D were inversely correlated with FAI, LH, total testosterone, AMH, androstenedione, TSH, and positively correlated with SHBG in reproductive-age women. The study recorded 508 reproductive age women, 157 of them were excluded because of various health problems after clinical evaluation (45 with autoimmune thyroiditis; 30 anemia; 24 leukocytosis; 42 abnormal liver function; 11 thrombopenia; four subclinical hyperthyroidisms; one unknown). The associations of total 25(OH)D with sex steroid hormones were inconsistently reported in either women with PCOS or healthy women (25–28). Indeed, an array of dietary supplements proposed to be useful in intervening with side effects due to declining hormone levels in men and women are promoted typically via media that lack scientific evidence. Boosting testosterone levels naturally is attainable through mindful nutrition, adequate sunlight exposure, and a healthy lifestyle. In contrast, Rafiq R et al. conducted a cross-sectional study on 643 Dutch men, which revealed a positive correlation between vitamin D (serum 25(OH)D) levels and both total and bioavailable testosterone levels.For initial parametric analyses, linear regression models were used to assess the association between serum vitamin B12 concentrations and reproductive hormones as continuous variables.Hence, if you are detected with low Vitamin D levels, then you can also assume that your testosterone levels are dropped down.A plethora of new research on this critica vitamin has shown it plays vital roles in more than just bone health.Studies are hinting at the link between Vitamin D and testosterone levels.Therefore, further research is necessary to verify effects of vitamin D supplementation on androgen levels in young, healthy men.These findings suggest that vitamin D may potentially influence fertility, prompting further investigation into its wider physiological consequences.Many individuals wonder whether taking vitamin D supplements can influence testosterone levels.It is the first comprehensive investigation exploring the relationship between serum vitamin B12 and several key male reproductive hormones in humans.Animal Reproduction Science. However, overdoing it with supplements can lead to these issues. It’s uncommon to get too much vitamin D from sunlight or foods. While it’s crucial to ensure you’re getting enough vitamin D, there’s also a risk in consuming too much. Resistance training and l-arginine supplementation are determinant in genomic stability, cardiac contractility and muscle mass development in rats. Carli G, Bonifazi M, Lodi L, Lupo C, Martelli G, Viti A. Changes in the exercise-induced hormone response to branched chain amino acid administration. Sharp CPM, Pearson DR. Amino acid supplements and recovery from high-intensity resistance training. Reversal of ciprofloxacin-induced testosterone reduction by probiotic microbes in mouse testes. However, literature about vitamin D and androstenedione is scarce.Only 6 out of 32 studies were assessed as having a low risk of bias due to their strong methodological study designs.Consider timing your supplements throughout the day rather than taking them all at once to maximize absorption and minimize potential stomach upset.In the second, the kidneys convert Vitamin D into calcitriol, the form of the hormone that is considered to be a hormone.Using a mediation analysis, we analyzed how BMI affected the relationship between 25(OH)D and testosterone.Vitamin D is a testosterone booster, but if your vitamin D levels are already optimal (most men don’t fall into this category), then extra supplementation won’t help.By adopting a more holistic view that includes lifestyle and nutritional factors, clinicians can better support men's health in a comprehensive and effective manner. Jorde et al.31 showed that supplementation with even high-dose vitamin D (20,000–40,000 IU/week for 6–12 months) does not lead to an increase in serum testosterone levels in healthy men. Correlative studies on vitamin d and total, free bioavailable testosterone levels in young, healthy men. However, additional studies did not support this observation (31), and vitamin D supplementation was not able to increase serum testosterone levels (32, 33). In an acute study (2 h) conducted in 8 men with a mean age of 21.3 ± 0.7 y, supplementation of 20 g of Korean red ginseng root extract did not increase testosterone concentrations (65), while in 30 healthy, endurance-trained men, aged between 18 and 40 y, Panax ginseng (an ethanolic liquid extract equivalent to 2 g of dried root, daily) did not increase testosterone concentrations after 6 wk of supplementation (38). Total and free vitamin D showed similar correlations with reproduction related endocrinological parameters, hematological parameters, liver function parameters, thrombophilia parameters and anemia related parameters in healthy reproductive age women. Kidney diseases and major liver diseases are usually rare in young women, thus the use of both ways of analysing the vitamin D status in this particular population is justified.The characteristics and outcomes of the included animal and human studies are presented in table II, III respectively, and they are categorized by the first author’s name, study type and duration of the follow-up period and sorted by the year of publication.Healthy sunlight exposure, dietary approaches, and supplementation can naturally influence vitamin D3 and testosterone levels.Moreover, also the studies that focused on patients with hypogonadism have shown controversial results.Recently, Barassi et al demonstrated a higher presence of VDD in arterial ED patients compared with non-arterial-ED patients and a lower serum VD levels in more severe ED patients.This important knowledge turned scientists to go in deep for the effect of VD on erectile function.Serum 25(OH)D and sex hormones have been measured. This systematic review aims to evaluate the association between vitamin D deficiency and testosterone levels in adult males and examine the effects of vitamin D supplementation on testosterone. Maintaining optimal vitamin D levels—whether through sunlight, diet, or supplements—can play a crucial role in supporting healthy testosterone production in 2025. Research indicates that correcting vitamin D deficiency with supplements can lead to a moderate increase in testosterone levels, particularly in deficient men. Scientific studies now suggest a positive correlation between adequate vitamin D levels and healthy testosterone production. One B vitamin that plays a very direct role in testosterone production is vitamin B6, which suppresses estrogen production, thus helping testosterone levels increase! Zinc status and serum testosterone levels of healthy adults. In addition to promoting cardiovascular health, the high vitamin D content in tuna correlates with increased testosterone levels. Measurement of 25(OH) vitamin D was performed by means of a chemiluminescence assay (Liaison XL, DiaSorin, Stillwater, MN) (intra-assay coefficients of variation were 3.8% at a vitamin D concentration of 7.85 ng/mL, 2.3% at 19.6 ng/mL, and 2% at 51.9 ng/mL).Because study after study has started to show an inextricable link between Vitamin D and Testosterone.Currently, there are no studies that would explain the mechanism of the possible effects of vitamin D on increasing or decreasing testosterone synthesis.Sönmez M, Türk G, Yüce A. The effect of ascorbic acid supplemen-tation on sperm quality, lipid peroxidation and testosterone levels of male wistar rats.We would like to thank Irtaza Tahir, Konrad Samsel, Matthew Pasquini, and Susan Lau for their support and assistance during the research study.The characteristics and outcomes of the included human studiesThe active biological form of vitamin D (known as calcitriol) is synthesized starting in the skin, with the initial synthesis of pre-vitamin D3 through a nonenzymatic reaction initialized by UV light, using 7-dehydrocholesterol7. However, further research is needed to fully understand the complex relationship and the potential influence of genetic variations, seasonal variations, and other factors such as BMI, age, and timing of testosterone measurements. This implies that individuals with different BMI categories may exhibit varying responses to vitamin D in terms of testosterone regulation. Additionally, a weak positive correlation between vitamin D levels and TT was observed, particularly among men with deficient or insufficient vitamin D status . These findings align with the results of Chen et al., supporting the potential role of vitamin D in testosterone regulation. However, supplements are most effective as part of a healthy lifestyle. Vitamin D supports the production of testosterone in the testes by enhancing the function of Leydig cells. Vitamin D isn’t just for keeping your bones strong; it can also help boost your testosterone levels naturally. As we discussed above, testosterone is synthesized from cholesterol and eggs are well known for their pure, unadulterated cholesterol levels. An excellent breakfast foods that boost testosterone, as they are considered one of the best sources of protein and are also a natural hormone booster. Oatmeal is an excellent source of a variety of B vitamins and therefore is one of the excellent testosterone-boosting foods. There are a number of different B vitamins, many of which are found in testosterone-boosting foods. The study was conducted in the winter season (December–March) in Lower Silesia, which is situated at the latitude of 51° 10′ N. The baseline characteristics of the study groups are presented in Table 1. The present study is a part of a project entitled Andrological Status of Young Men in Lower Silesia (AndroLS). We did not find an association between sex hormones and 25(OH)D in model 2, which included obesity type II (Table 4). All models were adjusted by age and smoking status. In this insight, we categorized our population study into three grades of obesity, being obesity type I (BMI ≥30 and 2), type II (BMI ≥35 and 2) and type III (BMI ≥40 kg/m2). As sunlight increases vitamin D, it signals your body to regulate testosterone, which can lead to better muscle strength, libido, and overall vitality. Sun exposure alone can improve not just vitamin D levels but also help optimize testosterone production naturally. One of the simplest ways to support does vitamin D boost testosterone levels is through safe sun exposure. Consult with a healthcare provider before starting any new supplement to determine the right dosage for your needs. If you struggle to get enough vitamin D from food and sunlight, supplements may be a beneficial option. Your body synthesizes vitamin D when your skin is exposed to sunlight. In summary, we need VD starting from the early embryonal days to the end of our lives for a better, healthy and sexually active life. Quantitative meta-analysis was not done because of various designs of included studies and small amount of human studies. An examination of the full text of these articles resulted in the exclusion of 25 studies. The flow diagram of the studies throughout the selection process is shown in Figure 1. Additional articles were identified from reference lists of included studies and relevant reviews. Admittedly, it's very unlikely you'll see vitamin A in a testosterone supplement. Natural testosterone boosters contain ingredients that help in naturally increasing testosterone production. Things like an unhealthy diet, a lack of exercise, and poor sleep significantly speed up this process. If you’re buying any kind of complex with Vitamin D–multivitamins, bone health formulas, T-boosters–check to see what kind of Vitamin D they are using. Testosterone benefits, whole body health and excellent tolerability make Vitamin D a great fit for any T-booster program. For reproductive hormones, the mean FSH, LH, TT, and prolactin concentration was 9.7 (±9.4) IU/L, 7.2 (±5.0) IU/L, 13.3 (±6.7) nd/dL, and 8.8 (±3.7) ng/mL, respectively. Serum vitamin B12 concentration was grouped into tertiles instead of being categorized based on deficiency and elevated concentration cutoffs. For parametric analyses, square root transformation was applied to reproductive hormones to normalize skewed distributions. Differences between the tertiles of serum vitamin B12 groups were assessed using chi-square test and analysis of variance for categorical variables and continuous variables, respectively. Descriptive statistics, including counts and the corresponding percentages relative to the total sample as well as mean (±SD), were used to summarize subject characteristics with categorical and continuous variables. In fact, vitamin D supports calcium and phosphorus absorption in the intestine, calcium reabsorption and phosphorus excretion in the kidney, and modulates the balance between bone formation and resorption in strict dependence of the circulating calcium level . The complex regulation of vitamin D metabolism is fundamental for the maintaining of a proper calciumphosphorus homeostasis. This in turn binds to the vitamin D responsive element located in the promoter regions of the target genes . The expression of VDR can be found in various organs, including bones, parathyroid glands, as well as reproductive organs . Differences reported in other studies that focussed on the relationship between vitamin D concentrations and sex hormone concentrations in young and older men may be due to the absence or presence of comorbidities related to age, lifestyle, and physical activity, which in turn may affect vitamin D and hormone levels. Conversely, it must also be mentioned that two different clinical studies found that vitamin D supplementation did not affect testosterone levels in men 34, 35. If you and your healthcare provider have decided to give it a try, they will likely monitor your vitamin D and testosterone levels before and after starting supplementation.